Tau 6D
In addition to the 3′ splice site at the end of exon 6, there are two alternate 3′ splice sites within exon 6 itself, termed “6P” and “6D” according to location (Fig. 1). Use of either of these splice sites results in a frame shift that introduces a unique amino acid sequence, PCCVPRATFLS (6P) or FWSKGDETQGG (6D), followed by a stop codon. As a result, tau 6P and 6D isoforms are truncated, lacking part of the proline-rich region, the MTBR region, and C-terminus
- Identifier
- CONSO00354
- Type
- isoform
- Author
- Sandra Spalek
https://orcid.org/0000-0002-6117-4413