GTS-21

GTS-21 is a derivative of the natural product anabaseine that acts as a partial agonist at neural nicotinic acetylcholine receptors. It binds to both the α4β2 and α7 subtypes, but activates only the α7 to any significant extent.

Identifier

CONSO00310

Type

chemical

Author

Charles Tapley Hoyt

https://orcid.org/0000-0003-4423-4370

References

• pubmed:25514383

Cross-references

• chemspider:4470526
• drugbank:DB05708
• inchi:InChI=1S/C19H20N2O2/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16/h3,6-9,11-13H,4-5,10H2,1-2H3/b15-11+
• pubchem.compound:5310985
• smiles:[H]\C(=C1\CCCN=C1C1=CN=CC=C1)C1=C(OC)C=C(OC)C=C1

Synonyms

Synonym	Reference	Specificity
(3E)-3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine	pubchem.compound:5310985	EXACT
(3E)-3-[(2,4-DIMETHOXYPHENYL)METHYLIDENE]-3,4,5,6-TETRAHYDRO-2,3''-BIPYRIDINE	pubchem.compound:5310985	EXACT
(3e)-3-[(2,4-Dimethoxyphenyl)methylidene]-3,4,5,6-Tetrahydro-2,3'-Bipyridine	pubchem.compound:5310985	EXACT
148372-04-7	pubchem.compound:5310985	EXACT
2,3'-Bipyridine, 3-((2,4-dimethoxyphenyl)methylene)-3,4,5,6-tetrahydro-, (3E)-	pubchem.compound:5310985	EXACT
2,3'-Bipyridine, 3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-, hydrochloride (1:2), (3E)-	pubchem.compound:5310985	EXACT
2,4-Dimethoxybenzylidene anabaseine	pubchem.compound:5310985	EXACT
2wnj	pubchem.compound:5310985	EXACT
3 (2,4 dimethoxybenzylidene)anabaseine	pubchem.compound:5310985	EXACT
3,4,5,6-Tetrahydro-3-(2,4-dimethoxybenzylidene)-2,3'-bipyridine	pubchem.compound:5310985	EXACT
3-(2,4-Dimethoxy-benzylidene)-3,4,5,6-tetrahydro-[2,3']bipyridinyl	pubchem.compound:5310985	EXACT
3-(2,4-Dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine	pubchem.compound:5310985	EXACT
3-(2,4-dimethoxybenzylidene)anabaseine	pubchem.compound:5310985	EXACT
3-(3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydropyridin-2-yl)pyridine	pubchem.compound:5310985	EXACT
3-(4-hydroxy-2-methoxybenzylidene)anabaseine	pubmed:25514383
3-[(2,4-dimethoxy)benzylidene]-anabaseine	pubchem.compound:5310985	EXACT
3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3'-Bipyridine	pubchem.compound:5310985	EXACT
3-[(3E)-3-[(2,4-DIMETHOXYPHENYL)METHYLIDENE]-5,6-DIHYDRO-4H-PYRIDIN-2-YL]PYRIDINE	pubchem.compound:5310985	EXACT
3-[(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-3,4,5,6-tetrahydropyridin-2-yl]pyridine	drugbank:DB05708
3-[(5E)-5-[(2,4-dimethoxyphenyl)methylidene]-3,4-dihydro-2H-pyridin-6-yl]pyridine	pubchem.compound:5310985	EXACT
3-[(E)-(2,4-Dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3'-bipyridine	pubchem.compound:5310985	EXACT
3-[1-(2,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-3,4,5,6-tetrahydro-[2,3'']bipyridinyl	pubchem.compound:5310985	EXACT
419A471	pubchem.compound:5310985	EXACT
8S399XDN2K	pubchem.compound:5310985	EXACT
A15950	pubchem.compound:5310985	EXACT
AC1NSJRW	pubchem.compound:5310985	EXACT
AKOS005146470	pubchem.compound:5310985	EXACT
ASIS-0106	pubchem.compound:5310985	EXACT
BBL035625	pubchem.compound:5310985	EXACT
BDBM50061564	pubchem.compound:5310985	EXACT
BDBM86543	pubchem.compound:5310985	EXACT
C19905	pubchem.compound:5310985	EXACT
CAS_156223-05-1	pubchem.compound:5310985	EXACT
CHEMBL134713	pubchem.compound:5310985	EXACT
DB05708	pubchem.compound:5310985	EXACT
DMXB-A	pubchem.compound:5310985	EXACT
Dimethoxybenzylidene anabaseine	pubchem.compound:5310985	EXACT
GTS 21	pubmed:25514383
GTS-21	drugbank:DB05708
Gts-21	pubchem.compound:5310985	EXACT
KB-77635	pubchem.compound:5310985	EXACT
MolPort-004-975-791	pubchem.compound:5310985	EXACT
NSC_122225	pubchem.compound:5310985	EXACT
SCHEMBL316745	pubchem.compound:5310985	EXACT
SCHEMBL316746	pubchem.compound:5310985	EXACT
STL441849	pubchem.compound:5310985	EXACT
UNII-8S399XDN2K	pubchem.compound:5310985	EXACT
X5074	pubchem.compound:5310985	EXACT
X5075	pubchem.compound:5310985	EXACT
ZINC860	pubchem.compound:5310985	EXACT

Incoming Relations

Identifier	Name	Relation
CONSO:CONSO00319	4-OH-GTS-21	metabolite_of

Outgoing Relations

None available.