8-nitro-cGMP
One of the major endogenus cGMP derivatives, a class of second messengers in the nitric oxide signalling pathway. It modifies the target protein's cysteine residues via a stable sulfide bond through the NO group of the guanine base, in a post translational modification also known as S-guanylation, a process involved in the regulation of the physiological roles of several important proteins. The S-guanylation of tau was shown to block the aggregation process and the subsequent formation of tau oligomers.
- Identifier
- CONSO00303
- Type
- chemical
- Author
- Kristian Kolpeja
https://orcid.org/0000-0001-9661-5277
References
Cross-references
- chebi:CHEBI:136665
- inchi:InChI=1S/C10H11N6O9P/c11-9-13-6-3(7(18)14-9)12-10(16(19)20)15(6)8-4(17)5-2(24-8)1-23-26(21,22)25-5/h2,4-5,8,17H,1H2,(H,21,22)(H3,11,13,14,18)/t2-,4-,5-,8-/m1/s1
- smiles:N1C(=NC2=C(N=C(N2[C@@H]3O[C@@H]4COP(O[C@H]4[C@H]3O)(=O)O)[N+]([O-])=O)C1=O)N