PrPSc

PrPSc (scrapie isoform of the prion protein) prions are the infectious agent behind diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy in cattle, chronic wasting disease in cervids (deer, elk, moose, and reindeer), as well as goat and sheep scrapie. PrPSc is an alternatively folded variant of the cellular prion protein, PrPC, which is a regular, GPI-anchored protein that is present on the cell surface of neurons and other cell types.

Identifier

CONSO00255

Type

isoform

Author

Kristian Kolpeja

https://orcid.org/0000-0001-9661-5277

References

• pubmed:22692785
• pubmed:29414853

Cross-references

• uniprot:F7VJQ1
• uniprot.isoform:F7VJQ1-1

Synonyms

None available.

Incoming Relations

None available.

Outgoing Relations

Relation	Identifier	Name
has_reference_protein	uniprot:P04156	PRIO_HUMAN