Long-Term Depression
A gradual weakening of neuronal synaptic connections lasting hours or longer following a long patterned stimulus. Along with LTP (long term potentiation) is one of the main mechanisms of memory formation, more specifically of spatial memory. The mechanism involves an interplay of NMDA and AMPA glutamate receptors, with minimal intracellular calcium levels triggering a cellular cascade leading to the removal of the latter and an overall decrease of the glutammate receptors in the postsynaptic neurons, thus weakening the synapse.
- Identifier
- CONSO00253
- Type
- pathology
- Author
- Kristian Kolpeja
https://orcid.org/0000-0001-9661-5277