ACY-1215

Ricolinostat is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity. Ricolinostat selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation. This leads to an accumulation of unfolded and misfolded ubiquitinated proteins and may eventually induce cancer cell apoptosis, and inhibition of cancer cell growth. HDAC6, a class II HDAC deacetylase located in the cytoplasm, appears to play a key role in the formation and activation of the aggresomes needed for degradation of misfolded proteins. Compared to non-selective HDAC inhibitor, ACY-1215 is able to reduce the toxic effects on normal, healthy cells.

Identifier

CONSO00234

Type

chemical

Author

Kristian Kolpeja

https://orcid.org/0000-0001-9661-5277

References

• pubmed:24844691

Cross-references

• cas:1316214-52-4
• chebi:CHEBI:95073
• drugbank:DB12376
• inchi:InChI=1S/C24H27N5O3/c30-22(28-32)15-9-1-2-10-16-25-23(31)19-17-26-24(27-18-19)29(20-11-5-3-6-12-20)21-13-7-4-8-14-21/h3-8,11-14,17-18,32H,1-2,9-10,15-16H2,(H,25,31)(H,28,30)
• mesh:C572255
• pubchem.compound:53340666
• smiles:C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=NC=C(C=N3)C(=O)NCCCCCCC(=O)NO

Synonyms

Synonym	Reference	Specificity
1316214-52-4	pubchem.compound:53340666	EXACT
2-(Diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide	pubchem.compound:53340666	EXACT
2-(Diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide	pubchem.compound:53340666	EXACT
2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamide	pubchem.compound:53340666	EXACT
5-Pyrimidinecarboxamide, 2-(diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)-	pubchem.compound:53340666	EXACT
5-Pyrimidinecarboxamide, 2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-	pubchem.compound:53340666	EXACT
7-{[2-(DIPHENYLAMINO)PYRIMIDIN-5-YL]FORMAMIDO}-N-HYDROXYHEPTANAMIDE	pubchem.compound:53340666	EXACT
A11940	pubchem.compound:53340666	EXACT
AB0032517	pubchem.compound:53340666	EXACT
AC-30258	pubchem.compound:53340666	EXACT
ACN-030031	pubchem.compound:53340666	EXACT
ACY-1215	pubchem.compound:53340666	EXACT
ACY-63	pubchem.compound:53340666	EXACT
ACY1215	pubchem.compound:53340666	EXACT
AH4	pubchem.compound:53340666	EXACT
AJ-128539	pubchem.compound:53340666	EXACT
AK151416	pubchem.compound:53340666	EXACT
AKOS024259260	pubchem.compound:53340666	EXACT
AX8288032	pubchem.compound:53340666	EXACT
BC600387	pubchem.compound:53340666	EXACT
BCP06028	pubchem.compound:53340666	EXACT
BDBM50439674	pubchem.compound:53340666	EXACT
CHEBI:95073	pubchem.compound:53340666	EXACT
CHEMBL2364628	pubchem.compound:53340666	EXACT
CS-0965	pubchem.compound:53340666	EXACT
D0TP9M	pubchem.compound:53340666	EXACT
D10661	pubchem.compound:53340666	EXACT
DB12376	pubchem.compound:53340666	EXACT
DTXSID40157148	pubchem.compound:53340666	EXACT
EX-A139	pubchem.compound:53340666	EXACT
GTPL7010	pubchem.compound:53340666	EXACT
HMS3653F17	pubchem.compound:53340666	EXACT
HY-16026	pubchem.compound:53340666	EXACT
J-690127	pubchem.compound:53340666	EXACT
KB-74507	pubchem.compound:53340666	EXACT
KS-00000SAV	pubchem.compound:53340666	EXACT
MFCD22666356	pubchem.compound:53340666	EXACT
MLS006011181	pubchem.compound:53340666	EXACT
MolPort-028-600-031	pubchem.compound:53340666	EXACT
N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide	pubchem.compound:53340666	EXACT
NCGC00345802-01	pubchem.compound:53340666	EXACT
NCGC00345802-05	pubchem.compound:53340666	EXACT
Ricolinostat	pubchem.compound:53340666	EXACT
Ricolinostat (ACY-1215)	pubchem.compound:53340666	EXACT
Ricolinostat (USAN/INN)	pubchem.compound:53340666	EXACT
Ricolinostat [USAN:INN]	pubchem.compound:53340666	EXACT
Rocilinostat	pubchem.compound:53340666	EXACT
Rocilinostat (ACY-1215)	pubchem.compound:53340666	EXACT
SB17054	pubchem.compound:53340666	EXACT
SCHEMBL574580	pubchem.compound:53340666	EXACT
SMR004702950	pubchem.compound:53340666	EXACT
ST24039648	pubchem.compound:53340666	EXACT
SW219836-1	pubchem.compound:53340666	EXACT
UNII-WKT909C62B	pubchem.compound:53340666	EXACT
US8609678, 2-(diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide [26]	pubchem.compound:53340666	EXACT
W-5979	pubchem.compound:53340666	EXACT
WKT909C62B	pubchem.compound:53340666	EXACT
X5832	pubchem.compound:53340666	EXACT
ZINC89630354	pubchem.compound:53340666	EXACT
rocilinostat-acy-1215	pubchem.compound:53340666	EXACT
s8001	pubchem.compound:53340666	EXACT

Incoming Relations

Identifier	Name	Relation
MESH:D000544	Alzheimer Disease	is_a

Outgoing Relations

None available.