3-3 dityrosine cross-linking

An oxidation product consisting of covalent ortho-ortho coupling between two tyrosine residues formed as a conseguence to UV irradiation, gamma-irradiation, aging, exposure to oxygen free radicals, nitrogen dioxide, peroxynitrite, and lipid hydroperoxides. ROS catalyzed by Cu ions are involved in the generation of these cross-links in amyloid beta oligomers to which they provide stability. Also involved in the stabilization of tau PHF. A potential biomarker of oxidative stress in AD.

Identifier
CONSO00209
Type
?
Author
Kristian Kolpeja
ORCID iD iconhttps://orcid.org/0000-0001-9661-5277

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