cystein-dependent auto-acetylation

Autocatalytic cysteine-mediated acetylation of Lys residues in the MTBR upon incubation of tau proteins with acetyl-CoA, possible even in absence of enzymatic activity.This activity may be suppressed when tau is bound to tubulin or MTs, but activated upon tau dissociation during pathological conditions that abrogate tau-MT interactions, thus allowing acetyl-CoA accessibility to free tau cysteines.