proteotoxicity
To function, proteins must undergo a folding process that gives them the proper three dimensional structure. Numerous genetic and biochemical observations suggest that proteins that fail to fold properly impair cell function. This process, also referred to as proteotoxicity, is particularly important to the fate of non-renewable cells of long-lived organisms in which malfolded proteins (proteotoxins) can exert their deleterious influence over extended periods of time.reference:Proteotoxicity and Aging
- Identifier
- CONSO00138
- Type
- pathology
- Author
- Lingling Xu
https://orcid.org/0000-0002-0303-8616