Mechanistic knowledge surrounding several neurodegenerative diseases, with specific focus on protein aggregation, nicotinic receptor signalling, proteostasis, and other mechanisms.
Each node in a BEL graph is assigned a type. Most nodes are then identified with a namespace:identifier pair, or a definition based on other nodes as in the case of complexes, composites, and chemical reactions.
| Reference | BEL |
|---|---|
| pubmed:30046111 | tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:Blood), toLoc(MESH:"Cerebrospinal Fluid")) regulates deg(a(CHEBI:amyloid-beta)) |
| pubmed:27299292 | a(CHEBI:amyloid-beta, loc(MESH:Astrocytes)) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:Brain), toLoc(MESH:Blood)) decreases a(CHEBI:amyloid-beta) |
| pubmed:30046111 | a(CHEBI:amyloid-beta) negativeCorrelation act(a(MESH:"Lymphatic Vessels")) |
| pubmed:30046111 | a(CHEBI:amyloid-beta) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:30046111 | a(CHEBI:amyloid-beta) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:30046111 | a(CHEBI:amyloid-beta) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29196815 | a(CHEBI:amyloid-beta) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29196815 | a(CHEBI:amyloid-beta) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23556446 | a(CHEBI:amyloid-beta) increases path(MESH:"Alzheimer Disease") |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases path(MESH:"Alzheimer Disease") |
| pubmed:19293145 | tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association path(MESH:"Alzheimer Disease") |
| pubmed:19293145 | a(CHEBI:amyloid-beta) association path(MESH:"Alzheimer Disease") |
| pubmed:25514383 | a(CHEBI:amyloid-beta) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:11230871 | a(CHEBI:amyloid-beta) increases path(MESH:"Alzheimer Disease") |
| pubmed:14556719 | a(CHEBI:amyloid-beta) association path(MESH:"Alzheimer Disease") |
| pubmed:29980653 | a(CHEBI:amyloid-beta) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:30046111 | a(CHEBI:amyloid-beta) association a(MESH:Macrophages) |
| pubmed:30663117 | a(CHEBI:amyloid-beta) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26813123 | a(CHEBI:amyloid-beta) regulates p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28745240 | a(CHEBI:amyloid-beta) decreases bp(GO:"calcium ion homeostasis") |
| pubmed:28745240 | a(CHEBI:amyloid-beta) association bp(MESH:"Oxidative Stress") |
| pubmed:28745240 | a(CHEBI:amyloid-beta) increases bp(MESH:"Oxidative Stress") |
| pubmed:28745240 | a(CHEBI:amyloid-beta) increases bp(GO:"apoptotic process") |
| pubmed:28745240 | a(CHEBI:amyloid-beta) increases bp(GO:"apoptotic process") |
| pubmed:27288790 | a(CHEBI:amyloid-beta) increases bp(GO:"apoptotic process") |
| pubmed:19293145 | act(a(CHEBI:amyloid-beta)) increases bp(GO:"apoptotic process") |
| pubmed:28745240 | a(CHEBI:amyloid-beta) increases bp(GO:"JNK cascade") |
| pubmed:28745240 | a(CHEBI:amyloid-beta) increases bp(GO:"Fas signaling pathway") |
| pubmed:28745240 | a(CHEBI:amyloid-beta) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | a(CHEBI:amyloid-beta) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | a(CHEBI:amyloid-beta) increases complex(GO:"NF-kappaB complex") |
| pubmed:28745240 | a(CHEBI:amyloid-beta) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | a(CHEBI:amyloid-beta) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:25652642 | a(CHEBI:amyloid-beta) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:25652642 | a(CHEBI:amyloid-beta) positiveCorrelation act(complex(GO:"NF-kappaB complex")) |
| pubmed:25652642 | a(CHEBI:amyloid-beta) decreases act(complex(GO:"NF-kappaB complex")) |
| pubmed:25652642 | a(CHEBI:amyloid-beta) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | a(CHEBI:amyloid-beta) decreases p(HGNC:BCL2L1) |
| pubmed:28745240 | a(CHEBI:amyloid-beta) decreases tloc(a(PUBCHEM:16057918), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28745240 | a(CHEBI:amyloid-beta) increases complex(a(GO:"membrane attack complex"), p(HGNC:C5)) |
| pubmed:28745240 | a(CHEBI:amyloid-beta) increases p(HGNC:TNF) |
| pubmed:29179999 | a(CHEBI:amyloid-beta) increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28019679 | a(CHEBI:amyloid-beta) increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28745240 | a(CHEBI:amyloid-beta) increases p(HGNC:APP) |
| pubmed:18930136 | a(CHEBI:amyloid-beta) association deg(p(HGNC:APP)) |
| pubmed:28745240 | a(CHEBI:amyloid-beta) increases act(complex(GO:"calcium- and calmodulin-dependent protein kinase complex")) |
| pubmed:28745240 | a(CHEBI:amyloid-beta) regulates act(p(FPLX:PKC)) |
| pubmed:28745240 | a(CHEBI:amyloid-beta) regulates bp(CONSO:"PI3K-Akt signaling pathway") |
| pubmed:28745240 | a(CHEBI:amyloid-beta) increases path(CONSO:neurotoxicity) |
| pubmed:25652642 | a(CHEBI:amyloid-beta) increases path(CONSO:neurotoxicity) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases path(CONSO:neurotoxicity) |
| pubmed:19293145 | act(a(CHEBI:amyloid-beta)) increases path(CONSO:neurotoxicity) |
| pubmed:19293145 | act(a(CHEBI:amyloid-beta)) increases path(CONSO:neurotoxicity) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases path(CONSO:neurotoxicity) |
| pubmed:19293145 | act(a(CHEBI:amyloid-beta)) increases path(CONSO:neurotoxicity) |
| pubmed:24590577 | a(CHEBI:amyloid-beta) increases path(CONSO:neurotoxicity) |
| pubmed:21882945 | a(CHEBI:amyloid-beta) increases path(CONSO:neurotoxicity) |
| pubmed:28745240 | a(CHEBI:amyloid-beta) increases a(CHEBI:"calcium(2+)") |
| pubmed:30688256 | a(CHEBI:amyloid-beta, loc(MESH:Mitochondria)) increases a(CHEBI:"calcium(2+)") |
| pubmed:28745240 | a(CHEBI:amyloid-beta) increases act(a(MESH:Microglia)) |
| pubmed:29179999 | a(CHEBI:amyloid-beta) increases bp(GO:"glial cell activation") |
| pubmed:29179999 | a(CHEBI:amyloid-beta) increases bp(GO:"inflammatory response") |
| pubmed:16566606 | a(CHEBI:amyloid-beta) increases bp(GO:"inflammatory response") |
| pubmed:29179999 | a(CHEBI:amyloid-beta) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:29179999 | a(CHEBI:amyloid-beta) increases tloc(p(HGNC:IL6), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:29179999 | a(CHEBI:amyloid-beta) increases act(p(FPLX:NFkappaB)) |
| pubmed:27288790 | a(CHEBI:amyloid-beta) increases act(p(FPLX:NFkappaB)) |
| pubmed:26010758 | a(CHEBI:amyloid-beta) increases act(p(FPLX:NFkappaB)) |
| pubmed:27288790 | a(CHEBI:amyloid-beta) increases act(p(HGNC:NFKB1)) |
| pubmed:27288790 | a(CHEBI:amyloid-beta) increases act(p(HGNC:RELA)) |
| pubmed:25652642 | a(CHEBI:amyloid-beta) increases act(p(HGNC:APOE)) |
| pubmed:26195256 | tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Cardiovascular System")) negativeCorrelation tloc(p(HGNC:APOE), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Cardiovascular System")) |
| pubmed:25652642 | a(CHEBI:amyloid-beta) increases bp(GO:"neuron death") |
| pubmed:21214928 | a(CHEBI:amyloid-beta) increases bp(GO:"neuron death") |
| pubmed:22122372 | a(CHEBI:amyloid-beta) increases bp(GO:"neuron death") |
| pubmed:22122372 | a(CHEBI:amyloid-beta) increases bp(GO:"neuron death") |
| pubmed:25652642 | a(CHEBI:amyloid-beta) increases r(HGNC:BAX) |
| pubmed:25652642 | a(CHEBI:amyloid-beta) decreases r(HGNC:BCL2L1) |
| pubmed:25652642 | a(CHEBI:amyloid-beta) increases a(MESH:"I-kappa B Proteins", loc(GO:cytoplasm)) |
| pubmed:29844403 | a(CHEBI:amyloid-beta) increases p(CONSO:"Tau aggregates") |
| pubmed:28500862 | a(CHEBI:amyloid-beta) positiveCorrelation p(CONSO:"Tau aggregates") |
| pubmed:29844403 | a(CHEBI:amyloid-beta) increases p(MESH:"Neurofibrillary Tangles") |
| pubmed:30232325 | a(CHEBI:amyloid-beta) increases path(CONSO:CONSO00061) |
| pubmed:21214928 | a(CHEBI:amyloid-beta) increases path(CONSO:CONSO00061) |
| pubmed:22122372 | a(CHEBI:amyloid-beta) increases path(CONSO:CONSO00061) |
| pubmed:22122372 | a(CHEBI:amyloid-beta) increases path(CONSO:CONSO00061) |
| pubmed:29196815 | a(CHEBI:amyloid-beta) increases bp(GO:"neuron apoptotic process") |
| pubmed:29196815 | a(CHEBI:amyloid-beta) increases complex(GO:"neurofibrillary tangle") |
| pubmed:29196815 | a(CHEBI:amyloid-beta) increases path(MESH:Gliosis) |
| pubmed:29196815 | a(CHEBI:amyloid-beta) increases path(MESH:"Neuroaxonal Dystrophies") |
| pubmed:18650430 | a(CHEBI:amyloid-beta) increases bp(GO:"cell adhesion") |
| pubmed:21214928 | a(CHEBI:amyloid-beta) increases path(MESH:"Plaque, Amyloid") |
| pubmed:21214928 | a(CHEBI:amyloid-beta) increases path(MESH:"Plaque, Amyloid") |
| pubmed:21214928 | a(CHEBI:amyloid-beta) increases path(CONSO:CONSO00027) |
| pubmed:21214928 | a(CHEBI:amyloid-beta) decreases bp(GO:"regulation of synapse structure or activity") |
| pubmed:21214928 | a(CHEBI:amyloid-beta) decreases bp(GO:"regulation of synapse structure or activity") |
| pubmed:22122372 | a(CHEBI:amyloid-beta) decreases bp(GO:"regulation of synapse structure or activity") |
| pubmed:22122372 | a(CHEBI:amyloid-beta) decreases bp(GO:"regulation of synapse structure or activity") |
| pubmed:21214928 | a(CHEBI:amyloid-beta) increases bp(GO:"neurofibrillary tangle assembly") |
| pubmed:22122372 | a(CHEBI:amyloid-beta) increases bp(GO:"neurofibrillary tangle assembly") |
| pubmed:21214928 | a(CHEBI:amyloid-beta) association bp(GO:"MAPK cascade") |
| pubmed:21214928 | a(CHEBI:amyloid-beta) association bp(GO:"ERK1 and ERK2 cascade") |
| pubmed:21214928 | a(CHEBI:amyloid-beta) decreases a(MESH:Synapses) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) decreases a(MESH:Synapses) |
| pubmed:21214928 | a(CHEBI:amyloid-beta) decreases bp(GO:memory) |
| pubmed:25514383 | a(CHEBI:amyloid-beta) increases bp(GO:memory) |
| pubmed:29758300 | tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases bp(GO:memory) |
| pubmed:22908190 | a(CHEBI:amyloid-beta) decreases bp(GO:memory) |
| pubmed:21214928 | a(CHEBI:amyloid-beta) association bp(MESH:"Synaptic Transmission") |
| pubmed:21214928 | a(CHEBI:amyloid-beta) decreases bp(GO:"long-term synaptic potentiation") |
| pubmed:21214928 | a(CHEBI:amyloid-beta) association a(MESH:"Potassium Channels") |
| pubmed:21214928 | a(CHEBI:amyloid-beta) increases bp(GO:"cell death") |
| pubmed:21214928 | a(CHEBI:amyloid-beta) association complex(p(HGNC:APBA1), p(HGNC:APP)) |
| pubmed:21214928 | tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association complex(p(HGNC:APBA1), p(HGNC:APP)) |
| pubmed:21214928 | a(CHEBI:amyloid-beta) association complex(p(HGNC:APBA2), p(HGNC:APP)) |
| pubmed:21214928 | tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association complex(p(HGNC:APBA2), p(HGNC:APP)) |
| pubmed:21214928 | a(CHEBI:amyloid-beta) association complex(p(HGNC:APBA3), p(HGNC:APP)) |
| pubmed:21214928 | tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association complex(p(HGNC:APBA3), p(HGNC:APP)) |
| pubmed:21214928 | a(CHEBI:amyloid-beta) association a(CHEBI:"phorbol ester") |
| pubmed:22122372 | a(CHEBI:amyloid-beta) decreases bp(GO:"learning or memory") |
| pubmed:22122372 | a(CHEBI:amyloid-beta) increases a(CONSO:CONSO00038) |
| pubmed:22122372 | a(CHEBI:amyloid-beta) increases a(CONSO:CONSO00018) |
| pubmed:21156028 | a(CHEBI:amyloid-beta) increases p(HGNC:DYRK1A) |
| pubmed:22262751 | a(CHEBI:amyloid-beta) association g(DBSNP:rs6656401) |
| pubmed:19419557 | a(CHEBI:amyloid-beta) association bp(GO:"calcium-mediated signaling") |
| pubmed:19293145 | act(a(CHEBI:amyloid-beta)) association bp(GO:"calcium-mediated signaling") |
| pubmed:26027813 | a(CHEBI:amyloid-beta) association a(NIFT:"Cortical Thickness") |
| pubmed:26996954 | a(CHEBI:amyloid-beta) positiveCorrelation a(NIFT:"Grey matter atrophy") |
| pubmed:30061532 | a(CHEBI:amyloid-beta) association path(MESH:"Lewy Body Disease") |
| pubmed:30515821 | a(CHEBI:amyloid-beta) increases act(p(HGNC:CDK5)) |
| pubmed:30515821 | a(CHEBI:amyloid-beta) increases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 579)) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:19293145 | a(CHEBI:amyloid-beta) association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:19293145 | a(CHEBI:amyloid-beta) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19293145 | a(CHEBI:amyloid-beta) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19293145 | a(CHEBI:amyloid-beta) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19293145 | a(CHEBI:amyloid-beta) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) positiveCorrelation p(HGNC:CHRNA7) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases act(p(HGNC:CHRNA7)) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) association p(HGNC:CHRNA7) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) decreases act(p(HGNC:CHRNA7)) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) causesNoChange p(HGNC:CHRNA7) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) causesNoChange act(p(HGNC:CHRNA7)) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases p(HGNC:CHRNA7) |
| pubmed:17009926 | a(CHEBI:amyloid-beta) positiveCorrelation p(HGNC:CHRNA7) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) positiveCorrelation p(HGNC:CHRNA4) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases p(HGNC:CHRNA4) |
| pubmed:17009926 | a(CHEBI:amyloid-beta) positiveCorrelation p(HGNC:CHRNA4) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases bp(GO:"intracellular receptor signaling pathway") |
| pubmed:19293145 | act(a(CHEBI:amyloid-beta)) association p(HGNC:FYN) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases act(p(HGNC:FYN)) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases act(p(FPLX:PI3K)) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr)) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases act(p(HGNC:MAPK8)) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases act(p(HGNC:MAPK14)) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) causesNoChange path(CONSO:Neurodegeneration) |
| pubmed:29758300 | tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) decreases path(CONSO:Neurodegeneration) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) decreases bp(MESH:"Neuronal Outgrowth") |
| pubmed:19293145 | a(CHEBI:amyloid-beta) decreases act(a(CHEBI:carbachol)) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases p(HGNC:BAX) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases act(p(HGNC:BAX)) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) decreases p(HGNC:BCL2) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) decreases act(p(HGNC:BCL2)) |
| pubmed:22530628 | a(CHEBI:amyloid-beta) increases complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases act(p(FPLX:JNK)) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases act(p(FPLX:ERK)) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases act(p(HGNC:BAD)) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) association bp(GO:"choline transport") |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases act(p(HGNC:CHRNA7, var("p.Leu250Thr"))) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) causesNoChange act(complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4))) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) decreases act(complex(p(HGNC:CHRNA2), p(HGNC:CHRNB2))) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2))) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) decreases act(p(HGNC:CHRNA7, var("?"))) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) decreases act(a(CHEBI:nicotine)) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases p(HGNC:CHRNA3) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) decreases p(RGD:Chrna4) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) decreases p(RGD:Chrna7) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases r(RGD:Chrna7) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases p(MGI:Chat) |
| pubmed:19293145 | a(CHEBI:amyloid-beta) increases r(MGI:Chrna3) |
| pubmed:17009926 | a(CHEBI:amyloid-beta) decreases a(CHEBI:acetylcholine) |
| pubmed:17009926 | a(CHEBI:amyloid-beta) decreases tloc(a(CHEBI:acetylcholine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:25514383 | a(CHEBI:amyloid-beta) increases act(a(CHEBI:acetylcholine)) |
| pubmed:17009926 | a(CHEBI:amyloid-beta) decreases act(p(FPLX:CHRM)) |
| pubmed:22530628 | a(CHEBI:amyloid-beta) positiveCorrelation path(MESH:"Memory Disorders") |
| pubmed:22530628 | a(CHEBI:amyloid-beta) positiveCorrelation path(DOID:dementia) |
| pubmed:26813123 | a(CHEBI:amyloid-beta) increases a(CONSO:"amyloid-beta fibrils") |
| pubmed:26813123 | act(a(CHEBI:amyloid-beta)) association act(p(HGNC:CHRM1)) |
| pubmed:24590577 | a(CHEBI:amyloid-beta) decreases act(p(HGNC:CHRM1)) |
| pubmed:31248781 | a(CHEBI:amyloid-beta) regulates p(MESH:"Receptors, Islet Amyloid Polypeptide") |
| pubmed:31248781 | act(a(CHEBI:amyloid-beta)) increases path(MESH:"Oxidative Stress") |
| pubmed:24590577 | a(CHEBI:amyloid-beta) decreases complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) |
| pubmed:26979166 | a(CHEBI:amyloid-beta, loc(GO:"extracellular space")) increases bp(GO:"microglial cell activation") |
| pubmed:30988501 | a(CHEBI:amyloid-beta, loc(GO:"extracellular matrix")) increases bp(GO:"microglial cell activation") |
| pubmed:25514383 | a(CHEBI:amyloid-beta) increases act(p(CONSO:"beta-2-containing nAChR")) |
| pubmed:25514383 | act(a(CHEBI:amyloid-beta)) negativeCorrelation p(CONSO:"alpha-7 beta-2 nAChR") |
| pubmed:25514383 | a(CHEBI:amyloid-beta) regulates act(p(FPLX:CHRN)) |
| pubmed:25514383 | a(CHEBI:amyloid-beta) decreases act(p(FPLX:CHRN)) |
| pubmed:25514383 | a(CHEBI:amyloid-beta) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:25514383 | a(CHEBI:amyloid-beta) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:25514383 | a(CHEBI:amyloid-beta) decreases bp(GO:"neuron cellular homeostasis") |
| pubmed:25514383 | a(CHEBI:amyloid-beta) decreases a(GO:synapse) |
| pubmed:22908190 | a(CHEBI:amyloid-beta) decreases act(a(GO:synapse)) |
| pubmed:26010758 | a(CHEBI:amyloid-beta) increases bp(GO:locomotion) |
| pubmed:26010758 | a(CHEBI:amyloid-beta) decreases path(MESH:Anxiety) |
| pubmed:26010758 | a(CHEBI:amyloid-beta) association path(MESH:"Interpersonal Relations") |
| pubmed:26010758 | a(CHEBI:amyloid-beta) increases p(HGNC:AIF1) |
| pubmed:26010758 | a(CHEBI:amyloid-beta) increases p(HGNC:PTPRC) |
| pubmed:26010758 | a(CHEBI:amyloid-beta) increases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26010758 | a(CHEBI:amyloid-beta) increases r(HGNC:BACE1) |
| pubmed:30688256 | a(CHEBI:amyloid-beta, loc(MESH:Mitochondria)) increases a(CHEBI:"reactive oxygen species") |
| pubmed:16566606 | a(CHEBI:amyloid-beta) increases a(CHEBI:"reactive oxygen species") |
| pubmed:30688256 | a(CHEBI:amyloid-beta, loc(MESH:Mitochondria)) decreases act(a(MESH:Mitochondria)) |
| pubmed:30688256 | a(CHEBI:amyloid-beta, loc(MESH:Mitochondria)) decreases a(MESH:Neurons) |
| pubmed:12428809 | a(CHEBI:amyloid-beta) association bp(GO:"axonal transport") |
| pubmed:21722302 | a(CHEBI:amyloid-beta) association p(HGNC:XBP1) |
| pubmed:21722302 | a(CHEBI:amyloid-beta) decreases tloc(a(CHEBI:"calcium cation"), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:cytoplasm)) |
| pubmed:29758300 | a(CHEBI:amyloid-beta) positiveCorrelation act(complex(GO:"TOR complex")) |
| pubmed:29758300 | a(CHEBI:amyloid-beta) negativeCorrelation bp(GO:macroautophagy) |
| pubmed:29758300 | a(CHEBI:amyloid-beta) increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29758300 | a(CHEBI:amyloid-beta) increases p(HGNC:TARDBP) |
| pubmed:29758300 | a(CHEBI:amyloid-beta) association complex(GO:"gamma-secretase complex") |
| pubmed:29758300 | a(CHEBI:amyloid-beta) positiveCorrelation p(HGNC:PICALM) |
| pubmed:29758300 | a(CHEBI:amyloid-beta) negativeCorrelation p(HGNC:SORL1) |
| pubmed:14556719 | a(CHEBI:amyloid-beta) decreases act(complex(GO:"proteasome complex")) |
| pubmed:22908190 | a(CHEBI:amyloid-beta) negativeCorrelation act(complex(GO:"proteasome complex")) |
| pubmed:14556719 | a(CHEBI:amyloid-beta) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:22908190 | a(CHEBI:amyloid-beta) positiveCorrelation bp(GO:endocytosis) |
| pubmed:22908190 | a(CHEBI:amyloid-beta) positiveCorrelation bp(GO:endocytosis) |
| pubmed:22908190 | tloc(a(CHEBI:amyloid-beta), fromLoc(GO:cytosol), toLoc(GO:autolysosome)) positiveCorrelation a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:25784053 | a(CHEBI:amyloid-beta) decreases act(p(FPLX:Proteasome)) |
| pubmed:24027553 | a(CHEBI:amyloid-beta) increases p(HGNC:MAPT, frag("?", "17kD")) |
| pubmed:24027553 | a(CHEBI:amyloid-beta) increases p(HGNC:MAPT, frag("?", "35kD")) |
| pubmed:24027553 | a(CHEBI:amyloid-beta) increases p(HGNC:MAPT, frag("?", "24kD")) |
| pubmed:24027553 | a(CHEBI:amyloid-beta) increases p(CONSO:"Tau C3") |
| pubmed:30126037 | a(CHEBI:amyloid-beta) causesNoChange p(MGI:Cdkn2a) |
| pubmed:30985105 | a(CHEBI:amyloid-beta) negativeCorrelation p(HGNC:APP, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:30985105 | a(CHEBI:amyloid-beta) association bp(GO:cognition) |
| pubmed:26195256 | a(CHEBI:amyloid-beta) positiveCorrelation g(CONSO:"APOE e4") |
| pubmed:26631930 | a(CHEBI:amyloid-beta) increases path(CONSO:Excitotoxicity) |
| pubmed:26631930 | a(CHEBI:amyloid-beta) increases path(CONSO:Excitotoxicity) |
| pubmed:29626319 | a(CHEBI:amyloid-beta) increases bp(GO:"response to oxidative stress") |
| pubmed:29626319 | a(CHEBI:amyloid-beta) positiveCorrelation bp(GO:aging) |
| pubmed:29421605 | a(CHEBI:amyloid-beta) positiveCorrelation bp(GO:aging) |
| pubmed:29626319 | a(CHEBI:amyloid-beta) positiveCorrelation path(MESH:"Diabetes Mellitus") |
| pubmed:29626319 | a(CHEBI:amyloid-beta) increases act(p(HGNC:MMP2)) |
| pubmed:29626319 | a(CHEBI:amyloid-beta) increases act(p(HGNC:MMP3)) |
| pubmed:29626319 | a(CHEBI:amyloid-beta) increases act(p(HGNC:MMP9)) |
| pubmed:29626319 | a(CHEBI:amyloid-beta) decreases a(MESH:"Cerebrospinal Fluid") |
| pubmed:29626319 | deg(a(CHEBI:amyloid-beta)) association p(HGNC:AQP4) |
| pubmed:19251756 | a(CHEBI:amyloid-beta) increases bp(GO:"response to nitrosative stress") |
| pubmed:19251756 | a(CHEBI:amyloid-beta) positiveCorrelation complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation"))) |
| pubmed:16566606 | a(CHEBI:amyloid-beta) increases a(CHEBI:"reactive nitrogen species") |
| pubmed:29221819 | a(CHEBI:amyloid-beta) positiveCorrelation p(MGI:Dyrk1a) |
| pubmed:28877763 | a(CHEBI:amyloid-beta) increases act(p(HGNC:SYK)) |
| pubmed:28877763 | a(CHEBI:amyloid-beta) increases a(CONSO:"dystrophic neurite") |
| pubmed:26118667 | a(CHEBI:amyloid-beta, loc(MESH:"Intracellular Space")) increases act(p(FPLX:CAPN)) |
| pubmed:22156579 | a(CHEBI:amyloid-beta) increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:22156579 | a(CHEBI:amyloid-beta) increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) |
| pubmed:22156579 | a(CHEBI:amyloid-beta) increases act(p(HGNC:MARK4)) |
| pubmed:22156579 | a(CHEBI:amyloid-beta) increases p(CONSO:"Tau epitope, PHF1", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25672970 | a(CHEBI:amyloid-beta) increases bp(GO:"neuroinflammatory response") |
| pubmed:28855586 | act(a(CHEBI:amyloid-beta)) negativeCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 163), pmod(go:0006473 ! "protein acetylation", Lys, 280), pmod(go:0006473 ! "protein acetylation", Lys, 281), pmod(go:0006473 ! "protein acetylation", Lys, 369)) |
| pubmed:25378699 | a(CHEBI:amyloid-beta) increases p(RGD:Mapt, pmod(CONSO:hyperphosphorylation), pmod(go:0016925 ! "protein sumoylation")) |
| pubmed:18675254 | a(CHEBI:amyloid-beta) negativeCorrelation p(HGNC:APP, pmod(go:0016925 ! "protein sumoylation", Lys, 587)) |
| pubmed:18675254 | a(CHEBI:amyloid-beta) negativeCorrelation p(HGNC:APP, pmod(go:0016925 ! "protein sumoylation", Lys, 595)) |
| pubmed:28019679 | a(CHEBI:amyloid-beta) increases bp(GO:"innate immune response") |
| pubmed:28019679 | a(CHEBI:amyloid-beta) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:23702978 | a(CHEBI:amyloid-beta) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:28019679 | a(CHEBI:amyloid-beta) increases a(CHEBI:"nitric oxide") |
| pubmed:28019679 | a(CHEBI:amyloid-beta) increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pubmed:28019679 | a(CHEBI:amyloid-beta) increases act(p(HGNC:CASP1)) |
| pubmed:23702978 | a(CHEBI:amyloid-beta) increases act(p(HGNC:NLRP3)) |
| pubmed:27314526 | a(CHEBI:amyloid-beta) association p(HGNC:NLRP3) |
| pubmed:23702978 | a(CHEBI:amyloid-beta) increases act(p(FPLX:TLR)) |
| pubmed:24561250 | a(CHEBI:amyloid-beta) increases act(complex(GO:"inflammasome complex")) |
| pubmed:24561250 | a(CHEBI:amyloid-beta) increases bp(GO:phagocytosis) |
| pubmed:24561250 | a(CHEBI:amyloid-beta) decreases a(GO:lysosome) |
| pubmed:30988501 | a(CHEBI:amyloid-beta, loc(GO:intracellular)) biomarkerFor path(DOID:"Alzheimer's disease") |
| pubmed:30046111 | bp(GO:phagocytosis) regulates deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | bp(GO:phagocytosis) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | bp(GO:phagocytosis) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | bp(GO:phagocytosis) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:30967783 | bp(GO:phagocytosis) increases deg(a(NCIT:C120869)) |
| pubmed:29626319 | bp(GO:phagocytosis) association p(HGNC:TREM2) |
| pubmed:29626319 | bp(GO:phagocytosis) association p(HGNC:ABCA7) |
| pubmed:29626319 | bp(GO:phagocytosis) association p(HGNC:CD33) |
| pubmed:29626319 | bp(GO:phagocytosis) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pubmed:29626319 | bp(GO:phagocytosis) decreases p(HGNC:MAPT) |
| pubmed:24561250 | bp(GO:phagocytosis) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:30988501 | bp(GO:phagocytosis) increases bp(GO:"activation of innate immune response") |
| pubmed:30046111 | a(MESH:Microglia) regulates deg(a(CHEBI:amyloid-beta)) |
| pubmed:26195256 | a(MESH:Microglia) decreases a(CHEBI:amyloid-beta, loc(MESH:"Extracellular Fluid")) |
| pubmed:26195256 | act(a(MESH:Microglia)) decreases a(CHEBI:amyloid-beta) |
| pubmed:28745240 | act(a(MESH:Microglia)) increases p(HGNC:TNF) |
| pubmed:30967783 | a(MESH:Microglia) increases p(HGNC:TNF) |
| pubmed:30988501 | a(MESH:Microglia) increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28745240 | act(a(MESH:Microglia)) increases p(HGNC:IL1B) |
| pubmed:30967783 | a(MESH:Microglia) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28745240 | act(a(MESH:Microglia)) increases p(HGNC:IL6) |
| pubmed:30967783 | a(MESH:Microglia) increases p(HGNC:IL6) |
| pubmed:30967783 | a(MESH:Microglia) increases tloc(p(HGNC:IL6), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28745240 | act(a(MESH:Microglia)) increases p(HGNC:CXCL8) |
| pubmed:28745240 | act(a(MESH:Microglia)) increases bp(GO:"neuron death") |
| pubmed:25652642 | act(a(MESH:Microglia)) positiveCorrelation a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:27794524 | a(MESH:Microglia) directlyIncreases tloc(a(CHEBI:"reactive oxygen species"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27794524 | a(MESH:Microglia) directlyIncreases a(CHEBI:"reactive oxygen species") |
| pubmed:27794524 | a(MESH:Microglia) directlyIncreases tloc(a(CHEBI:"reactive nitrogen species"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27794524 | a(MESH:Microglia) directlyIncreases a(CHEBI:"reactive nitrogen species") |
| pubmed:27794524 | a(MESH:Microglia) directlyIncreases a(CHEBI:"nitric oxide") |
| pubmed:27794524 | a(MESH:Microglia) association a(PUBCHEM:54677946) |
| pubmed:26445701 | act(a(MESH:Microglia)) increases path(MESH:Inflammation) |
| pubmed:30967783 | a(MESH:Microglia) decreases path(MESH:Inflammation) |
| pubmed:30967783 | a(MESH:Microglia) regulates bp(MESH:Homeostasis) |
| pubmed:30967783 | a(MESH:Microglia) increases complex(p(HGNC:CX3CL1), p(HGNC:CX3CR1)) |
| pubmed:30967783 | a(MESH:Microglia) increases bp(MESH:"Neuronal Plasticity") |
| pubmed:30967783 | a(MESH:Microglia) increases bp(MESH:"Neuronal Plasticity") |
| pubmed:30967783 | a(MESH:Microglia) increases bp(MESH:"Neuronal Plasticity") |
| pubmed:30967783 | a(MESH:Microglia) decreases bp(MESH:"Neuronal Plasticity") |
| pubmed:30967783 | a(MESH:Microglia) increases bp(GO:"generation of neurons") |
| pubmed:30967783 | a(MESH:Microglia) increases p(HGNC:IGF1) |
| pubmed:30967783 | a(MESH:Microglia) increases bp(GO:"learning or memory") |
| pubmed:30988501 | a(MESH:Microglia) increases bp(GO:"learning or memory") |
| pubmed:30967783 | a(MESH:Microglia) increases a(GO:synapse) |
| pubmed:30967783 | a(MESH:Microglia) increases p(HGNC:BDNF) |
| pubmed:30967783 | a(MESH:Microglia) increases bp(GO:"apoptotic cell clearance") |
| pubmed:30967783 | a(MESH:Microglia) increases deg(p(MESH:Proteins, pmod(CONSO:misfolded))) |
| pubmed:30967783 | a(MESH:Microglia) decreases p(MESH:Proteins, pmod(CONSO:misfolded)) |
| pubmed:30967783 | a(MESH:Microglia) increases p(HGNC:IFNG) |
| pubmed:30967783 | a(MESH:Microglia) increases p(MESH:Interleukin-23) |
| pubmed:30967783 | a(MESH:Microglia) increases p(HGNC:NOS2) |
| pubmed:30967783 | a(MESH:Microglia) increases p(HGNC:CCL4) |
| pubmed:30967783 | a(MESH:Microglia) increases p(HGNC:CCL5) |
| pubmed:30967783 | a(MESH:Microglia) increases tloc(p(HGNC:CCL5), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30967783 | a(MESH:Microglia) increases p(HGNC:CCL8) |
| pubmed:30967783 | a(MESH:Microglia) increases p(HGNC:CXCL2) |
| pubmed:30967783 | a(MESH:Microglia) increases p(HGNC:PF4) |
| pubmed:30967783 | a(MESH:Microglia) increases p(HGNC:CXCL9) |
| pubmed:30967783 | a(MESH:Microglia) isA a(MESH:"Antigen-Presenting Cells") |
| pubmed:30967783 | a(MESH:Microglia) isA a(MESH:"Antigen-Presenting Cells") |
| pubmed:30967783 | a(MESH:Microglia) increases bp(MESH:"Adaptive Immunity") |
| pubmed:30967783 | a(MESH:Microglia) increases p(HGNC:IL4) |
| pubmed:30967783 | a(MESH:Microglia) increases p(HGNC:IL10) |
| pubmed:30967783 | a(MESH:Microglia) increases p(HGNC:IL13) |
| pubmed:30967783 | a(MESH:Microglia) increases p(HGNC:TGFB1) |
| pubmed:30967783 | a(MESH:Microglia) regulates bp(MESH:Immunity) |
| pubmed:30967783 | a(MESH:Microglia) increases bp(GO:"tissue remodeling") |
| pubmed:30967783 | a(MESH:Microglia) increases bp(GO:angiogenesis) |
| pubmed:30967783 | a(MESH:Microglia) increases deg(a(MESH:Parasites)) |
| pubmed:30967783 | a(MESH:Microglia) increases bp(GO:"oligodendrocyte differentiation") |
| pubmed:30967783 | a(MESH:Microglia) increases bp(MESH:Remyelination) |
| pubmed:30967783 | a(MESH:Microglia) increases bp(GO:"brain development") |
| pubmed:28669544 | a(MESH:Microglia) regulates bp(GO:"brain development") |
| pubmed:30967783 | a(MESH:Microglia) regulates bp(MESH:"Neural Pathways") |
| pubmed:28669544 | a(MESH:Microglia) regulates bp(MESH:"Neural Pathways") |
| pubmed:30967783 | a(MESH:Microglia) decreases bp(GO:cognition) |
| pubmed:30967783 | a(MESH:Microglia) increases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30967783 | a(MESH:Microglia) increases tloc(p(HGNC:CCL2), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30967783 | a(MESH:Microglia) increases path(DOID:"multiple sclerosis") |
| pubmed:30967783 | a(MESH:Microglia) increases deg(a(MESH:"Myelin Sheath")) |
| pubmed:30967783 | a(MESH:Microglia) increases bp(GO:phagocytosis) |
| pubmed:29626319 | act(a(MESH:Microglia)) increases bp(GO:phagocytosis) |
| pubmed:29626319 | a(MESH:Microglia) increases bp(GO:phagocytosis) |
| pubmed:30967783 | a(MESH:Microglia) increases bp(MESH:Neuroprotection) |
| pubmed:30967783 | a(MESH:Microglia) increases bp(MESH:Neuroprotection) |
| pubmed:30967783 | a(MESH:Microglia) increases a(MESH:Cytokines) |
| pubmed:26195256 | act(a(MESH:Microglia)) increases a(MESH:Cytokines) |
| pubmed:30967783 | a(MESH:Microglia) increases p(HGNC:TREM2) |
| pubmed:30967783 | act(a(MESH:Microglia)) increases a(MESH:"Glatiramer Acetate") |
| pubmed:23178521 | a(MESH:Microglia) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pubmed:23383175 | a(MESH:Microglia) positiveCorrelation a(MESH:Astrocytes) |
| pubmed:23383175 | a(MESH:Microglia) negativeCorrelation a(GO:"myelin sheath") |
| pubmed:29202785 | act(a(MESH:Microglia)) negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) |
| pubmed:29202785 | act(a(MESH:Microglia)) positiveCorrelation p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pubmed:28528849 | a(MESH:Microglia) regulates act(p(CONSO:"Tau oligomers", var("p.Lys280del"))) |
| pubmed:29626319 | act(a(MESH:Microglia)) increases bp(GO:"immune response") |
| pubmed:29626319 | act(a(MESH:Microglia)) increases bp(GO:"cytokine production involved in inflammatory response") |
| pubmed:29626319 | act(a(MESH:Microglia)) increases bp(GO:"inflammatory response") |
| pubmed:29238289 | a(MESH:Microglia) increases tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28669544 | a(MESH:Microglia) isA bp(MESH:"Immunity, Innate") |
| pubmed:28669544 | a(MESH:Microglia) regulates path(MESH:"Neural Pathways") |
| pubmed:28669544 | a(MESH:Microglia) regulates bp(GO:"nervous system development") |
| pubmed:28669544 | a(MESH:Microglia) decreases a(MESH:Synapses) |
| pubmed:28669544 | a(MESH:Microglia) directlyDecreases a(MESH:Synapses) |
| pubmed:28669544 | a(MESH:Microglia) decreases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:28669544 | a(MESH:Microglia) association path(DOID:"neurodegenerative disease") |
| pubmed:28669544 | a(MESH:Microglia) regulates path(MESH:"Immune System") |
| pubmed:28669544 | a(MESH:Microglia) regulates path(MESH:Phagocytosis) |
| pubmed:28669544 | a(MESH:Microglia) regulates deg(p(CONSO:"protein aggregates")) |
| pubmed:28669544 | a(MESH:Microglia, loc(CONSO:"amyloid-beta oligomers")) increases path(MESH:"Neuronal Plasticity") |
| pubmed:27314526 | a(MESH:Microglia) increases p(HGNC:NLRP3) |
| pubmed:27314526 | a(MESH:Microglia) increases p(HGNC:P2RX7) |
| pubmed:27314526 | a(MESH:Microglia) increases p(HGNC:TLR4) |
| pubmed:30988501 | a(MESH:Microglia) increases bp(MESH:"Immunologic Surveillance") |
| pubmed:30988501 | a(MESH:Microglia) increases bp(GO:"complement-mediated synapse pruning") |
| pubmed:30988501 | a(MESH:Microglia) increases bp(GO:"central nervous system development") |
| pubmed:30988501 | a(MESH:Microglia) association bp(GO:"synaptic signaling") |
| pubmed:30988501 | a(MESH:Microglia) increases tloc(a(MESH:"Extracellular Vesicles"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30988501 | a(MESH:Microglia) increases bp(GO:"regulation of neuronal synaptic plasticity") |
| pubmed:30988501 | a(MESH:Microglia) increases bp(GO:"motor learning") |
| pubmed:30046111 | a(MESH:Monocytes) regulates deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | a(MESH:Monocytes) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | a(MESH:Monocytes) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:30967783 | a(MESH:Monocytes, loc(MESH:"Blood-Brain Barrier")) directlyIncreases a(MESH:Macrophages, loc(MESH:"Blood-Brain Barrier")) |
| pubmed:30967783 | a(MESH:Monocytes, loc(GO:"node of Ranvier")) increases path(HP:"CNS demyelination") |
| pubmed:30967783 | a(MESH:Monocytes) causesNoChange a(MESH:Microglia) |
| pubmed:30046111 | a(MESH:Macrophages) regulates deg(a(CHEBI:amyloid-beta)) |
| pubmed:30046111 | a(MESH:Macrophages) association a(CHEBI:amyloid-beta) |
| pubmed:26195256 | a(MESH:Macrophages) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:30962309 | a(MESH:Macrophages) increases m(MIRBASE:hsa-mir-302b) |
| pubmed:27794524 | a(MESH:Macrophages) directlyIncreases a(CHEBI:"reactive oxygen species") |
| pubmed:27794524 | a(MESH:Macrophages) directlyIncreases a(CHEBI:"reactive nitrogen species") |
| pubmed:27794524 | a(MESH:Macrophages) directlyIncreases a(CHEBI:"nitric oxide") |
| pubmed:30967783 | a(MESH:Macrophages) regulates bp(MESH:Homeostasis) |
| pubmed:30967783 | a(MESH:Macrophages) increases bp(GO:"neuroinflammatory response") |
| pubmed:30967783 | a(MESH:Macrophages) increases path(DOID:"multiple sclerosis") |
| pubmed:30967783 | a(MESH:Macrophages) increases bp(MESH:Neuroprotection) |
| pubmed:30967783 | a(MESH:Macrophages) increases bp(MESH:Neuroprotection) |
| pubmed:30967783 | a(MESH:Macrophages, loc(MESH:Brain)) increases bp(MESH:Neuroprotection) |
| pubmed:30967783 | a(MESH:Macrophages) decreases path(MESH:Inflammation) |
| pubmed:30967783 | a(MESH:Macrophages) increases path(MESH:Inflammation) |
| pubmed:30967783 | a(MESH:Macrophages) increases bp(GO:"establishment of blood-brain barrier") |
| pubmed:30967783 | a(MESH:Macrophages) increases bp(MESH:Immunity) |
| pubmed:30967783 | a(MESH:Macrophages) increases bp(MESH:Immunity) |
| pubmed:30967783 | a(MESH:Macrophages) increases a(MESH:"Leukocytes, Mononuclear") |
| pubmed:30967783 | a(MESH:Macrophages) decreases act(a(MESH:"Leukocytes, Mononuclear")) |
| pubmed:30967783 | a(MESH:Macrophages) decreases a(MESH:"Leukocytes, Mononuclear", loc(MESH:"Central Nervous System")) |
| pubmed:30967783 | a(MESH:Macrophages) isA a(MESH:"Antigen-Presenting Cells") |
| pubmed:30967783 | a(MESH:Macrophages) isA a(MESH:"Antigen-Presenting Cells") |
| pubmed:30967783 | a(MESH:Macrophages) isA a(MESH:"Antigen-Presenting Cells") |
| pubmed:30967783 | a(MESH:Macrophages) decreases a(NCIT:C120869) |
| pubmed:30967783 | a(MESH:Macrophages) increases bp(GO:"cerebrospinal fluid secretion") |
| pubmed:30967783 | a(MESH:Macrophages) increases bp(GO:"cerebrospinal fluid circulation") |
| pubmed:30967783 | a(MESH:Macrophages) increases p(HGNC:TRPM2) |
| pubmed:30967783 | a(MESH:Macrophages) increases tloc(p(HGNC:IL6), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30967783 | a(MESH:Macrophages) increases tloc(p(HGNC:IL12B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30967783 | a(MESH:Macrophages) increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30967783 | a(MESH:Macrophages) increases tloc(p(HGNC:IL1A), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30967783 | a(MESH:Macrophages) increases tloc(p(MESH:Interleukin-23), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30967783 | a(MESH:Macrophages) increases p(HGNC:CCR4) |
| pubmed:30967783 | a(MESH:Macrophages) increases path(HP:"CNS demyelination") |
| pubmed:30967783 | a(MESH:Macrophages) increases p(HGNC:TREM1) |
| pubmed:30967783 | a(MESH:Macrophages) increases p(MESH:"Histocompatibility Antigens Class II") |
| pubmed:30967783 | a(MESH:Macrophages) increases path(EFO:"experimental autoimmune encephalomyelitis") |
| pubmed:30967783 | a(MESH:Macrophages) decreases path(EFO:"experimental autoimmune encephalomyelitis") |
| pubmed:30967783 | a(MESH:Macrophages) increases p(HGNC:VCAM1) |
| pubmed:30967783 | a(MESH:Macrophages) increases p(HGNC:ICAM1) |
| pubmed:30967783 | a(MESH:Macrophages) increases p(HGNC:CCL2) |
| pubmed:30967783 | a(MESH:Macrophages) increases p(HGNC:CCL3) |
| pubmed:30967783 | a(MESH:Macrophages) increases bp(GO:"T cell activation") |
| pubmed:30967783 | a(MESH:Macrophages) increases p(MESH:"Nerve Growth Factors") |
| pubmed:30967783 | a(MESH:Macrophages) increases p(MESH:"Anti-Inflammatory Agents") |
| pubmed:30967783 | a(MESH:Macrophages) decreases p(HGNC:IFNG) |
| pubmed:30967783 | a(MESH:Macrophages, loc(MESH:Brain)) regulates a(MESH:Microglia) |
| pubmed:30046111 | a(CONSO:CONSO00018) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21718217 | a(CONSO:CONSO00018) association path(MESH:"Alzheimer Disease") |
| pubmed:30046111 | a(CONSO:CONSO00018) decreases bp(GO:"neuron cellular homeostasis") |
| pubmed:30046111 | a(CONSO:CONSO00018) increases path(MESH:"Problem Behavior") |
| pubmed:29196815 | a(CONSO:CONSO00018) causesNoChange bp(GO:"neuron death") |
| pubmed:29196815 | a(CONSO:CONSO00018) causesNoChange bp(GO:"astrocyte activation") |
| pubmed:22122372 | a(CONSO:CONSO00018) association a(MESH:"Amyloid beta-Peptides") |
| pubmed:22122372 | a(CONSO:CONSO00018) increases path(MESH:"Plaque, Amyloid") |
| pubmed:30046111 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:CONSO00018) |
| pubmed:21718217 | path(MESH:"Alzheimer Disease") association a(CONSO:CONSO00018) |
| pubmed:22040696 | path(MESH:"Alzheimer Disease") increases a(CONSO:CONSO00018) |
| pubmed:30046111 | path(MESH:"Alzheimer Disease") association act(a(MESH:"Lymphatic Vessels")) |
| pubmed:30046111 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:30046111 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:30046111 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") association tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") association a(CHEBI:amyloid-beta) |
| pubmed:25514383 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:14556719 | path(MESH:"Alzheimer Disease") association a(CHEBI:amyloid-beta) |
| pubmed:26195256 | path(MESH:"Alzheimer Disease") decreases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | path(MESH:"Alzheimer Disease") decreases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | path(MESH:"Alzheimer Disease") increases a(CHEBI:amyloid-beta) |
| pubmed:29980653 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:30663117 | path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:BACE1, loc(GO:cytoplasm)) |
| pubmed:21329555 | path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:BACE1) |
| pubmed:30663117 | path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:BACE1-AS) |
| pubmed:30663117 | path(MESH:"Alzheimer Disease") association g(HGNC:MIR384) |
| pubmed:30663117 | path(MESH:"Alzheimer Disease") association g(HGNC:MIR153-1) |
| pubmed:30663117 | path(MESH:"Alzheimer Disease") association g(HGNC:MIR101-1) |
| pubmed:30663117 | path(MESH:"Alzheimer Disease") association g(HGNC:MIR9-1) |
| pubmed:30663117 | path(MESH:"Alzheimer Disease") decreases g(HGNC:MIR9-1) |
| pubmed:16273023 | path(MESH:"Alzheimer Disease") decreases a(CHEBI:acetylcholine) |
| pubmed:16273023 | path(MESH:"Alzheimer Disease") decreases act(a(CHEBI:acetylcholine)) |
| pubmed:26218288 | path(MESH:"Alzheimer Disease") negativeCorrelation a(CHEBI:acetylcholine) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases a(CHEBI:acetylcholine) |
| pubmed:25514383 | path(MESH:"Alzheimer Disease") decreases a(CHEBI:acetylcholine) |
| pubmed:16273023 | path(MESH:"Alzheimer Disease") negativeCorrelation a(CL:"cholinergic neuron") |
| pubmed:16273023 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:ACHE)) |
| pubmed:26813123 | path(MESH:"Alzheimer Disease") association p(HGNC:ACHE) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") decreases p(HGNC:ACHE) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") causesNoChange act(p(HGNC:ACHE)) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") decreases act(p(HGNC:ACHE)) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") decreases act(p(HGNC:ACHE)) |
| pubmed:11230871 | path(MESH:"Alzheimer Disease") decreases act(p(HGNC:ACHE)) |
| pubmed:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:ACHE)) |
| pubmed:11230871 | path(MESH:"Alzheimer Disease") decreases act(p(HGNC:ACHE)) |
| pubmed:16273023 | path(MESH:"Alzheimer Disease") association p(HGNC:REST) |
| pubmed:16273023 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SEPT2) |
| pubmed:16273023 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SEPT3) |
| pubmed:16273023 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:SEPT5) |
| pubmed:" 23273601" | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:VAMP2) |
| pubmed:" 23273601" | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:SNAP25) |
| pubmed:" 23273601" | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:SYN1) |
| pubmed:" 23273601" | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:SYN2) |
| pubmed:" 23273601" | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:SYT1) |
| pubmed:" 23273601" | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:SYT5) |
| pubmed:" 23273601" | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:DNM1) |
| pubmed:" 23273601" | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:DNM1L) |
| pubmed:" 23273601" | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:SYNPO) |
| pubmed:" 23273601" | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:RAB3A) |
| pubmed:" 23273601" | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:SEC22B) |
| pubmed:" 23273601" | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:SNCA) |
| pubmed:" 23273601" | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:SNCB) |
| pubmed:" 23273601" | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:STXBP5L) |
| pubmed:" 23273601" | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:STXBP6) |
| pubmed:" 23273601" | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:BSN) |
| pubmed:" 23273601" | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PCLO) |
| pubmed:" 23273601" | path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:SNAP23) |
| pubmed:" 23273601" | path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:SYNPO2) |
| pubmed:" 23273601" | path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:VAMP1) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:VAMP1) |
| pubmed:26218288 | path(MESH:"Alzheimer Disease") positiveCorrelation path(HP:"Neuronal loss in central nervous system") |
| pubmed:24107444 | path(MESH:"Alzheimer Disease") negativeCorrelation g(HGNC:PSEN1) |
| pubmed:17361039 | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:SLC1A3) |
| pubmed:17361039 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:SLC1A3) |
| pubmed:17361039 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SLC1A3) |
| pubmed:17361039 | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:SLC1A2) |
| pubmed:17361039 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:SLC1A2) |
| pubmed:17361039 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SLC1A2) |
| pubmed:17361039 | path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:GRIK4) |
| pubmed:17361039 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:POLR2M) |
| pubmed:17361039 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:GRIA4) |
| pubmed:25932647 | path(MESH:"Alzheimer Disease") negativeCorrelation p(INTERPRO:"Serine/threonine-protein kinase MARK/par1") |
| pubmed:21329555 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RELA) |
| pubmed:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RELA, loc(GO:nucleus)) |
| pubmed:21329555 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Inflammation) |
| pubmed:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Inflammation) |
| pubmed:24027553 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Inflammation) |
| pubmed:28745240 | path(MESH:"Alzheimer Disease") association p(HGNC:IL6) |
| pubmed:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL6) |
| pubmed:28745240 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TNF) |
| pubmed:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TNF) |
| pubmed:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TNF) |
| pubmed:29179999 | path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:NFkappaB) |
| pubmed:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation act(p(FPLX:NFkappaB)) |
| pubmed:27288790 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"regulation of synaptic plasticity") |
| pubmed:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"reactive oxygen species") |
| pubmed:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) |
| pubmed:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) |
| pubmed:24561250 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) |
| pubmed:27314526 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) |
| pubmed:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL18) |
| pubmed:24561250 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL18) |
| pubmed:27314526 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL18) |
| pubmed:27314526 | path(MESH:"Alzheimer Disease") association p(HGNC:IL18) |
| pubmed:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CXCL10) |
| pubmed:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TGFB1) |
| pubmed:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"MAPK cascade") |
| pubmed:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:pentosidine) |
| pubmed:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:GLAP) |
| pubmed:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PTGS2) |
| pubmed:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation m(MIRBASE:hsa-mir-146a) |
| pubmed:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation m(MIRBASE:hsa-mir-155) |
| pubmed:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation complex(a(GO:"NF-kappaB complex"), p(HGNC:RELA)) |
| pubmed:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation act(complex(GO:"NF-kappaB complex")) |
| pubmed:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation complex(GO:"NF-kappaB complex") |
| pubmed:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation complex(GO:"NF-kappaB complex") |
| pubmed:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:"HLA-DR Antigens") |
| pubmed:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR9-1) |
| pubmed:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR34A) |
| pubmed:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR125B1) |
| pubmed:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR146A) |
| pubmed:24586483 | path(MESH:"Alzheimer Disease") association m(HGNC:MIR146A) |
| pubmed:24586483 | path(MESH:"Alzheimer Disease") association m(HGNC:MIR146A) |
| pubmed:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR155) |
| pubmed:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR339) |
| pubmed:10656250 | path(MESH:"Alzheimer Disease") increases p(HGNC:BACE1) |
| pubmed:30444369 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:HSD17B10) |
| pubmed:30444369 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:PRDX2)) |
| pubmed:30444369 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PRDX2) |
| pubmed:30444369 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CDK5) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") association p(HGNC:CDK5) |
| pubmed:8282104 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CDK5) |
| pubmed:30444369 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SH3GL2) |
| pubmed:29196815 | path(MESH:"Alzheimer Disease") isA path(MESH:"Neurodegenerative Diseases") |
| pubmed:24511233 | path(MESH:"Alzheimer Disease") isA path(MESH:"Neurodegenerative Diseases") |
| pubmed:24590577 | path(MESH:"Alzheimer Disease") isA path(MESH:"Neurodegenerative Diseases") |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") association path(MESH:"Neurodegenerative Diseases") |
| pubmed:29980653 | path(MESH:"Alzheimer Disease") isA path(MESH:"Neurodegenerative Diseases") |
| pubmed:29196815 | path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) |
| pubmed:19126755 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:cognition) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) |
| pubmed:24511233 | path(MESH:"Alzheimer Disease") association bp(GO:cognition) |
| pubmed:24511233 | path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) |
| pubmed:24590577 | path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) |
| pubmed:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:cognition) |
| pubmed:19721446 | path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) |
| pubmed:29196815 | path(MESH:"Alzheimer Disease") increases bp(GO:"neuron apoptotic process") |
| pubmed:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pubmed:19126755 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") association path(MESH:"Plaque, Amyloid") |
| pubmed:24590577 | path(MESH:"Alzheimer Disease") association path(MESH:"Plaque, Amyloid") |
| pubmed:25514383 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pubmed:19721446 | path(MESH:"Alzheimer Disease") increases path(MESH:"Plaque, Amyloid") |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pubmed:14556719 | path(MESH:"Alzheimer Disease") increases path(MESH:"Plaque, Amyloid") |
| pubmed:22817713 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pubmed:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:"Amyloid beta-Peptides") |
| pubmed:22122372 | path(MESH:"Alzheimer Disease") association a(MESH:"Amyloid beta-Peptides") |
| pubmed:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:"neurofibrillary tangle") |
| pubmed:28420982 | path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:"neurofibrillary tangle") |
| pubmed:22817713 | path(MESH:"Alzheimer Disease") association a(GO:"neurofibrillary tangle") |
| pubmed:11089576 | path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:"neurofibrillary tangle") |
| pubmed:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:CONSO00074) |
| pubmed:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:CONSO00074) |
| pubmed:29196815 | path(MESH:"Alzheimer Disease") negativeCorrelation a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") association a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:CONSO00076) |
| pubmed:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:NGFR) |
| pubmed:21214928 | path(MESH:"Alzheimer Disease") positiveCorrelation r(CONSO:CONSO00064) |
| pubmed:21214928 | path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:CONSO00065) |
| pubmed:22122372 | path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:CONSO00065) |
| pubmed:21214928 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:ADAM10) |
| pubmed:21214928 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:ADAM10)) |
| pubmed:21214928 | path(MESH:"Alzheimer Disease") negativeCorrelation p(CONSO:CONSO00067) |
| pubmed:22122372 | path(MESH:"Alzheimer Disease") association bp(GO:"neurofibrillary tangle assembly") |
| pubmed:22122372 | path(MESH:"Alzheimer Disease") association bp(GO:"neuron death") |
| pubmed:14970312 | path(MESH:"Alzheimer Disease") increases bp(GO:"neuron death") |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") increases bp(GO:"neuron death") |
| pubmed:17009926 | path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death") |
| pubmed:17009926 | path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death") |
| pubmed:24590577 | path(MESH:"Alzheimer Disease") increases bp(GO:"neuron death") |
| pubmed:25514383 | path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death") |
| pubmed:22040696 | path(MESH:"Alzheimer Disease") increases bp(GO:"neuron death") |
| pubmed:28420982 | path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death") |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death") |
| pubmed:22122372 | path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:CONSO00064) |
| pubmed:22110360 | path(MESH:"Alzheimer Disease") association p(HGNC:DYRK1A) |
| pubmed:26136662 | path(MESH:"Alzheimer Disease") association p(FPLX:Histone, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:27041503 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) |
| pubmed:3122646 | path(MESH:"Alzheimer Disease") increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"cell body")) |
| pubmed:25514383 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") association p(HGNC:MAPT) |
| pubmed:14556719 | path(MESH:"Alzheimer Disease") association p(HGNC:MAPT) |
| pubmed:24027553 | path(MESH:"Alzheimer Disease") association p(HGNC:MAPT) |
| pubmed:24027553 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) |
| pubmed:27574109 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) |
| pubmed:27574109 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) |
| pubmed:30126037 | path(MESH:"Alzheimer Disease") association p(HGNC:MAPT) |
| pubmed:22419736 | path(MESH:"Alzheimer Disease") causesNoChange p(HGNC:MAPT) |
| pubmed:25374103 | path(MESH:"Alzheimer Disease") increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) |
| pubmed:28420982 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) |
| pubmed:28420982 | path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT) |
| pubmed:28420982 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) |
| pubmed:20869593 | path(MESH:"Alzheimer Disease") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:8282104 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24027553 | path(MESH:"Alzheimer Disease") regulates p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29191965 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29191965 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29311797 | path(MESH:"Alzheimer Disease") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26458742 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22817713 | path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22710270 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PSEN1, var("p.Glu280Ala")) |
| pubmed:22710270 | path(MESH:"Alzheimer Disease") association g(HGNC:CD44) |
| pubmed:22710270 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs187116) |
| pubmed:22710270 | path(MESH:"Alzheimer Disease") association g(HGNC:NPHP1) |
| pubmed:22710270 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs10173717) |
| pubmed:22710270 | path(MESH:"Alzheimer Disease") association g(HGNC:CADPS2) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:CADPS2) |
| pubmed:22710270 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs3757536) |
| pubmed:22710270 | path(MESH:"Alzheimer Disease") association g(HGNC:GREM2) |
| pubmed:22710270 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs12129547) |
| pubmed:21769591 | path(MESH:"Alzheimer Disease") association p(HGNC:APOE) |
| pubmed:22159054 | path(MESH:"Alzheimer Disease") association p(HGNC:APOE) |
| pubmed:18191876 | path(MESH:"Alzheimer Disease") association p(HGNC:A2M, var("p.Val1000Ile")) |
| pubmed:18191876 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs669) |
| pubmed:18191876 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs669) |
| pubmed:18191876 | path(MESH:"Alzheimer Disease") association p(HGNC:OLR1) |
| pubmed:18191876 | path(MESH:"Alzheimer Disease") association p(HGNC:OLR1) |
| pubmed:20693622 | path(MESH:"Alzheimer Disease") association p(HGNC:CYP46A1) |
| pubmed:20693622 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs8003602) |
| pubmed:20693622 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs3783320) |
| pubmed:19926167 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs17571) |
| pubmed:21892414 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CLU) |
| pubmed:22159054 | path(MESH:"Alzheimer Disease") association p(HGNC:CLU) |
| pubmed:21892414 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs9331888) |
| pubmed:22382309 | path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:CD33) |
| pubmed:22167654 | path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:CD33) |
| pubmed:21460841 | path(MESH:"Alzheimer Disease") association g(HGNC:CD33) |
| pubmed:22382309 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs3865444) |
| pubmed:21460841 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs3865444) |
| pubmed:22382309 | path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:MS4A6A) |
| pubmed:22382309 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs610932) |
| pubmed:21460840 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs610932) |
| pubmed:22167654 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs3826656) |
| pubmed:22167654 | path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:GOLM1) |
| pubmed:22167654 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs10868366) |
| pubmed:22167654 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs7019241) |
| pubmed:21285854 | path(MESH:"Alzheimer Disease") association g(HGNC:GAB2) |
| pubmed:17553421 | path(MESH:"Alzheimer Disease") association g(HGNC:GAB2) |
| pubmed:21285854 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs4945261) |
| pubmed:21285854 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs7101429) |
| pubmed:21285854 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs7115850) |
| pubmed:22159054 | path(MESH:"Alzheimer Disease") association p(HGNC:NECTIN2) |
| pubmed:22159054 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs6859) |
| pubmed:22159054 | path(MESH:"Alzheimer Disease") association p(HGNC:PICALM) |
| pubmed:29626319 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PICALM) |
| pubmed:27260836 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PICALM) |
| pubmed:22159054 | path(MESH:"Alzheimer Disease") association p(HGNC:BIN1) |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:BIN1) |
| pubmed:22159054 | path(MESH:"Alzheimer Disease") association p(HGNC:EPHA1) |
| pubmed:22159054 | path(MESH:"Alzheimer Disease") association p(HGNC:MS4A7) |
| pubmed:22159054 | path(MESH:"Alzheimer Disease") association p(HGNC:ABCA7) |
| pubmed:23556446 | path(MESH:"Alzheimer Disease") association p(HGNC:ABCA7) |
| pubmed:22159054 | path(MESH:"Alzheimer Disease") association p(HGNC:CD33) |
| pubmed:22005930 | path(MESH:"Alzheimer Disease") association g(HGNC:SLC29A2) |
| pubmed:22005930 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs6834555) |
| pubmed:22005930 | path(MESH:"Alzheimer Disease") association g(HGNC:VSNL1) |
| pubmed:22005930 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs4038131) |
| pubmed:21460840 | path(MESH:"Alzheimer Disease") association g(HGNC:ABCA7) |
| pubmed:21460840 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs3764650) |
| pubmed:21460840 | path(MESH:"Alzheimer Disease") association g(HGNC:MS4A1) |
| pubmed:18823527 | path(MESH:"Alzheimer Disease") association g(HGNC:LRAT) |
| pubmed:18823527 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs201825) |
| pubmed:18823527 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs727153) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:PICALM) |
| pubmed:21627779 | path(MESH:"Alzheimer Disease") association g(HGNC:PICALM) |
| pubmed:21460841 | path(MESH:"Alzheimer Disease") association g(HGNC:PICALM) |
| pubmed:21379329 | path(MESH:"Alzheimer Disease") association g(HGNC:PICALM) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs3851179) |
| pubmed:21379329 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs3851179) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:APOE) |
| pubmed:19734903 | path(MESH:"Alzheimer Disease") association g(HGNC:APOE) |
| pubmed:20460622 | path(MESH:"Alzheimer Disease") association g(HGNC:APOE) |
| pubmed:20885792 | path(MESH:"Alzheimer Disease") association g(HGNC:APOE) |
| pubmed:17474819 | path(MESH:"Alzheimer Disease") association g(HGNC:APOE) |
| pubmed:21123754 | path(MESH:"Alzheimer Disease") association g(HGNC:APOE) |
| pubmed:10936883 | path(MESH:"Alzheimer Disease") association g(HGNC:APOE) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:APOE) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs2075650) |
| pubmed:20460622 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs2075650) |
| pubmed:20061627 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs2075650) |
| pubmed:20885792 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs2075650) |
| pubmed:21123754 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs2075650) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:CLU) |
| pubmed:19734903 | path(MESH:"Alzheimer Disease") association g(HGNC:CLU) |
| pubmed:21627779 | path(MESH:"Alzheimer Disease") association g(HGNC:CLU) |
| pubmed:21460841 | path(MESH:"Alzheimer Disease") association g(HGNC:CLU) |
| pubmed:21379329 | path(MESH:"Alzheimer Disease") association g(HGNC:CLU) |
| pubmed:" 26517285" | path(MESH:"Alzheimer Disease") increases g(HGNC:CLU) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs11136000) |
| pubmed:19734903 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs11136000) |
| pubmed:21379329 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs11136000) |
| pubmed:21543606 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs11136000) |
| pubmed:19734903 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs6656401) |
| pubmed:19136949 | path(MESH:"Alzheimer Disease") association g(HGNC:PCDH11X) |
| pubmed:19136949 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs5984894) |
| pubmed:19118814 | path(MESH:"Alzheimer Disease") association g(HGNC:FAM13B) |
| pubmed:19118814 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs11610206) |
| pubmed:18976728 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs11159647) |
| pubmed:18976728 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs4420638) |
| pubmed:17474819 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs4420638) |
| pubmed:17975299 | path(MESH:"Alzheimer Disease") association g(HGNC:SORL1) |
| pubmed:22005931 | path(MESH:"Alzheimer Disease") association g(HGNC:DCHS2) |
| pubmed:22005931 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs1466662) |
| pubmed:21627779 | path(MESH:"Alzheimer Disease") association g(HGNC:BIN1) |
| pubmed:21460841 | path(MESH:"Alzheimer Disease") association g(HGNC:BIN1) |
| pubmed:21390209 | path(MESH:"Alzheimer Disease") association g(HGNC:BIN1) |
| pubmed:21379329 | path(MESH:"Alzheimer Disease") association g(HGNC:BIN1) |
| pubmed:21627779 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs744373) |
| pubmed:21390209 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs744373) |
| pubmed:21627779 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs569214) |
| pubmed:21627779 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs536841) |
| pubmed:21627779 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs1562990) |
| pubmed:20061627 | path(MESH:"Alzheimer Disease") association g(HGNC:TOMM40) |
| pubmed:21123754 | path(MESH:"Alzheimer Disease") association g(HGNC:TOMM40) |
| pubmed:21460841 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs5616655) |
| pubmed:21460841 | path(MESH:"Alzheimer Disease") association g(HGNC:MS4A4A) |
| pubmed:21460841 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs4938933) |
| pubmed:21460841 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs7561528) |
| pubmed:21379329 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs7561528) |
| pubmed:21460841 | path(MESH:"Alzheimer Disease") association g(HGNC:CR1) |
| pubmed:21460841 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs6701713) |
| pubmed:21460841 | path(MESH:"Alzheimer Disease") association g(HGNC:CD2AP) |
| pubmed:21460841 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs9349407) |
| pubmed:21460841 | path(MESH:"Alzheimer Disease") association g(HGNC:EPHA1) |
| pubmed:21460841 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs11767557) |
| pubmed:21460841 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs1532278) |
| pubmed:21390209 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs12989701) |
| pubmed:21379329 | path(MESH:"Alzheimer Disease") association g(HGNC:CELF2) |
| pubmed:21379329 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs201119) |
| pubmed:20885792 | path(MESH:"Alzheimer Disease") association g(HGNC:MTHFD1L) |
| pubmed:20885792 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs11754661) |
| pubmed:17553421 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs2373115) |
| pubmed:21123754 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs429358) |
| pubmed:21123754 | path(MESH:"Alzheimer Disease") association g(HGNC:EPC2) |
| pubmed:21123754 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs4499362) |
| pubmed:21123754 | path(MESH:"Alzheimer Disease") association g(HGNC:CCDC134) |
| pubmed:21123754 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs7364180) |
| pubmed:23022416 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs3818361) |
| pubmed:23022416 | path(MESH:"Alzheimer Disease") association composite(g(DBSNP:rs3818361), g(DBSNP:rs429358)) |
| pubmed:22236693 | path(MESH:"Alzheimer Disease") negativeCorrelation g(DBSNP:rs2072446) |
| pubmed:22236693 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs2072446) |
| pubmed:22236693 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs741072) |
| pubmed:22236693 | path(MESH:"Alzheimer Disease") negativeCorrelation g(DBSNP:rs734194) |
| pubmed:22236693 | path(MESH:"Alzheimer Disease") negativeCorrelation g(DBSNP:rs734194) |
| pubmed:29183403 | path(MESH:"Alzheimer Disease") negativeCorrelation g(DBSNP:rs142787485) |
| pubmed:29183403 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RAB10) |
| pubmed:21709374 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs1050283) |
| pubmed:18191876 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs1050283) |
| pubmed:18191876 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs12316150) |
| pubmed:19660836 | path(MESH:"Alzheimer Disease") negativeCorrelation g(DBSNP:rs4135263) |
| pubmed:19660836 | path(MESH:"Alzheimer Disease") negativeCorrelation g(DBSNP:rs1151999) |
| pubmed:19660836 | path(MESH:"Alzheimer Disease") negativeCorrelation g(DBSNP:rs709149) |
| pubmed:19660836 | path(MESH:"Alzheimer Disease") negativeCorrelation g(DBSNP:rs709154) |
| pubmed:19660836 | path(MESH:"Alzheimer Disease") association g(HGNC:PPARG) |
| pubmed:19660836 | path(MESH:"Alzheimer Disease") negativeCorrelation g(HGNC:PPARG) |
| pubmed:21548758 | path(MESH:"Alzheimer Disease") association g(HGNC:HNRNPA1) |
| pubmed:24162737 | path(MESH:"Alzheimer Disease") association g(HGNC:SQSTM1) |
| pubmed:22005930 | path(MESH:"Alzheimer Disease") association g(HGNC:STK11) |
| pubmed:21390209 | path(MESH:"Alzheimer Disease") association g(HGNC:AGRN) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:AGRN) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:MIR146A) |
| pubmed:24586483 | path(MESH:"Alzheimer Disease") association g(HGNC:MIR146A) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:CSF3R) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:DAB2) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:DAB1) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:BTBD3) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:SKAP2) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:NAV3) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:MKI67) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:ANXA1) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:SPTLC1) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:GRIN3A) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:STIM2) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:GRIK2) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:ROBO2) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:RYR2) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:FOXO3) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:SLC25A21) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:RELN) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:GRIK4) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:APBA1) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:RYR3) |
| pubmed:19734902 | path(MESH:"Alzheimer Disease") association g(HGNC:ATP2A3) |
| pubmed:23535033 | path(MESH:"Alzheimer Disease") association g(HGNC:CAMK4) |
| pubmed:23535033 | path(MESH:"Alzheimer Disease") association g(HGNC:CYCS) |
| pubmed:22107728 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs4646953) |
| pubmed:23279143 | path(MESH:"Alzheimer Disease") association p(HGNC:SORCS1) |
| pubmed:23279143 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs7907690) |
| pubmed:23279143 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs7907690) |
| pubmed:23279143 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs601883) |
| pubmed:23279143 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs17277986) |
| pubmed:23279143 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs2900717) |
| pubmed:23279143 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs10884399) |
| pubmed:23279143 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs11193170) |
| pubmed:23279143 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs4918280) |
| pubmed:23279143 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs600879) |
| pubmed:23403532 | path(MESH:"Alzheimer Disease") association complex(p(HGNC:NRXN1), p(INTERPRO:Neuroligin)) |
| pubmed:23403532 | path(MESH:"Alzheimer Disease") association complex(p(HGNC:NRXN2), p(INTERPRO:Neuroligin)) |
| pubmed:23403532 | path(MESH:"Alzheimer Disease") association complex(p(HGNC:NRXN3), p(INTERPRO:Neuroligin)) |
| pubmed:21036197 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs411280) |
| pubmed:24586483 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs57095329) |
| pubmed:25038421 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs998382) |
| pubmed:25038421 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs2424913) |
| pubmed:22691691 | path(MESH:"Alzheimer Disease") association p(HGNC:DRD4) |
| pubmed:" 26517285" | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"microglial cell activation") |
| pubmed:28877763 | path(MESH:"Alzheimer Disease") increases bp(GO:"microglial cell activation") |
| pubmed:25687773 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs393152) |
| pubmed:25687773 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs393152) |
| pubmed:25687773 | path(MESH:"Alzheimer Disease") association path(MESH:Atrophy) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") increases path(MESH:Atrophy) |
| pubmed:26195256 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Atrophy) |
| pubmed:26195256 | path(MESH:"Alzheimer Disease") decreases path(MESH:Atrophy) |
| pubmed:19419557 | path(MESH:"Alzheimer Disease") decreases p(HGNC:GRIN1) |
| pubmed:19419557 | path(MESH:"Alzheimer Disease") decreases p(HGNC:GRIN2A) |
| pubmed:19419557 | path(MESH:"Alzheimer Disease") decreases p(HGNC:GRIN2B) |
| pubmed:19419557 | path(MESH:"Alzheimer Disease") association p(HGNC:CALHM1, var("p.Pro86Leu")) |
| pubmed:23556446 | path(MESH:"Alzheimer Disease") association p(HGNCGENEFAMILY:"ATP binding cassette subfamily A") |
| pubmed:23556446 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs3752246) |
| pubmed:23556446 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs3740066) |
| pubmed:23556446 | path(MESH:"Alzheimer Disease") association p(HGNC:ABCC2) |
| pubmed:23556446 | path(MESH:"Alzheimer Disease") association p(HGNC:ABCC2, var("p.Cys3972Thr")) |
| pubmed:20100581 | path(MESH:"Alzheimer Disease") association a(NIFT:"Grey matter volume") |
| pubmed:20100581 | path(MESH:"Alzheimer Disease") association p(HGNC:NXPH1) |
| pubmed:16151770 | path(MESH:"Alzheimer Disease") negativeCorrelation a(NIFT:"Cerebral blood flow") |
| pubmed:23300102 | path(MESH:"Alzheimer Disease") negativeCorrelation a(NIFT:"Cerebral blood flow") |
| pubmed:23300102 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"glucose metabolic process") |
| pubmed:26195256 | path(MESH:"Alzheimer Disease") decreases bp(GO:"glucose metabolic process") |
| pubmed:26836182 | path(MESH:"Alzheimer Disease") positiveCorrelation path(CONSO:neuroinflammation) |
| pubmed:22550605 | path(MESH:"Alzheimer Disease") association p(HGNC:TOMM40, var("?")) |
| pubmed:26996954 | path(MESH:"Alzheimer Disease") increases p(HGNC:APP, frag("672_713")) |
| pubmed:14970312 | path(MESH:"Alzheimer Disease") increases p(HGNC:APP, frag("672_713")) |
| pubmed:21543606 | path(MESH:"Alzheimer Disease") decreases a(NIFT:"White matter") |
| pubmed:14970312 | path(MESH:"Alzheimer Disease") association bp(MESH:"Oxidative Stress") |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") positiveCorrelation bp(MESH:"Oxidative Stress") |
| pubmed:14970312 | path(MESH:"Alzheimer Disease") association bp(GO:"sphingolipid metabolic process") |
| pubmed:14970312 | path(MESH:"Alzheimer Disease") association bp(GO:"cholesterol metabolic process") |
| pubmed:30061532 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:30145931 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:17403556 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:25374103 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:24401760 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:19126755 | path(MESH:"Alzheimer Disease") negativeCorrelation p(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:19126755 | path(MESH:"Alzheimer Disease") negativeCorrelation p(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") association p(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:19721446 | path(MESH:"Alzheimer Disease") decreases p(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:19126755 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19126755 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19126755 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:24590577 | path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19721446 | path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19126755 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA7) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") association p(HGNC:CHRNA7) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA7) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") increases p(HGNC:CHRNA7) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA7) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA7) |
| pubmed:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA7) |
| pubmed:22040696 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA7) |
| pubmed:29191965 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CHRNA7) |
| pubmed:19126755 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Dementia) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") association path(MESH:Dementia) |
| pubmed:24511233 | path(MESH:"Alzheimer Disease") association path(MESH:Dementia) |
| pubmed:25514383 | path(MESH:"Alzheimer Disease") association path(MESH:Dementia) |
| pubmed:21718217 | path(MESH:"Alzheimer Disease") increases path(MESH:Dementia) |
| pubmed:14556719 | path(MESH:"Alzheimer Disease") increases path(MESH:Dementia) |
| pubmed:19126755 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"synaptic transmission, cholinergic") |
| pubmed:24511233 | path(MESH:"Alzheimer Disease") decreases bp(GO:"synaptic transmission, cholinergic") |
| pubmed:24511233 | path(MESH:"Alzheimer Disease") decreases bp(GO:"synaptic transmission, cholinergic") |
| pubmed:26813123 | path(MESH:"Alzheimer Disease") association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:24590577 | path(MESH:"Alzheimer Disease") decreases bp(GO:"synaptic transmission, cholinergic") |
| pubmed:19126755 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Neurofibrillary Tangles") |
| pubmed:24590577 | path(MESH:"Alzheimer Disease") association path(MESH:"Neurofibrillary Tangles") |
| pubmed:24027553 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Neurofibrillary Tangles") |
| pubmed:19126755 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Neurogenic Inflammation") |
| pubmed:19126755 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA4) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA4) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA4) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA4) |
| pubmed:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA4) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases bp(GO:memory) |
| pubmed:24511233 | path(MESH:"Alzheimer Disease") decreases bp(GO:memory) |
| pubmed:24511233 | path(MESH:"Alzheimer Disease") decreases bp(GO:memory) |
| pubmed:22040696 | path(MESH:"Alzheimer Disease") decreases bp(GO:memory) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases path(MESH:"Psychomotor Performance") |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") association path(MESH:Death) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:"Neurofibrillary Tangles") |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") association a(MESH:"Neurofibrillary Tangles") |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") increases a(MESH:"Neurofibrillary Tangles") |
| pubmed:14556719 | path(MESH:"Alzheimer Disease") increases a(MESH:"Neurofibrillary Tangles") |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") association a(CONSO:"amyloid-beta aggregates") |
| pubmed:25514383 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"amyloid-beta aggregates") |
| pubmed:26195256 | path(MESH:"Alzheimer Disease") increases a(CONSO:"amyloid-beta aggregates") |
| pubmed:22817713 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"amyloid-beta aggregates") |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") increases p(HGNC:BCHE) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") increases act(p(HGNC:BCHE)) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT)) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT)) |
| pubmed:26813123 | path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT)) |
| pubmed:24590577 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHAT) |
| pubmed:25514383 | path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT)) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHAT) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases act(a(MESH:"Cholinesterase Inhibitors")) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") association g(HGNC:CHAT) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") association g(HGNC:ACHE) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") increases p(HGNC:FYN) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") increases p(HGNC:FYN) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") increases complex(p(HGNC:FYN), p(HGNC:MAPT)) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") positiveCorrelation complex(p(HGNC:FYN), p(HGNC:MAPT)) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") association act(p(HGNC:INS)) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") association bp(GO:"regulation of cytosolic calcium ion concentration") |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") association p(HGNC:PSEN1) |
| pubmed:21722302 | path(MESH:"Alzheimer Disease") increases p(HGNC:PSEN1) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") association bp(GO:learning) |
| pubmed:24511233 | path(MESH:"Alzheimer Disease") decreases bp(GO:learning) |
| pubmed:24511233 | path(MESH:"Alzheimer Disease") decreases bp(GO:learning) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") association path(MESH:"Cognitive Dysfunction") |
| pubmed:24511233 | path(MESH:"Alzheimer Disease") association path(MESH:"Cognitive Dysfunction") |
| pubmed:24511233 | path(MESH:"Alzheimer Disease") association path(MESH:"Cognitive Dysfunction") |
| pubmed:26813123 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pubmed:27522251 | path(MESH:"Alzheimer Disease") increases path(MESH:"Cognitive Dysfunction") |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") |
| pubmed:24511233 | path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") |
| pubmed:26813123 | path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"Cholinergic Neurons") |
| pubmed:24590577 | path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") |
| pubmed:24590577 | path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) |
| pubmed:21787755 | path(MESH:"Alzheimer Disease") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA3) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA3) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA3) |
| pubmed:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA3) |
| pubmed:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA3) |
| pubmed:11230871 | path(MESH:"Alzheimer Disease") causesNoChange p(HGNC:CHRNA3) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") causesNoChange r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNB4) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor AMPA type subunits") |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:GABRB3) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") causesNoChange p(MGI:Chrna7) |
| pubmed:25881725 | path(MESH:"Alzheimer Disease") negativeCorrelation p(MGI:Chrna7) |
| pubmed:19293145 | path(MESH:"Alzheimer Disease") causesNoChange p(MGI:Chrna4) |
| pubmed:24511233 | path(MESH:"Alzheimer Disease") association path(MESH:"Psychotic Disorders") |
| pubmed:24511233 | path(MESH:"Alzheimer Disease") association path(MESH:"Psychotic Disorders") |
| pubmed:24511233 | path(MESH:"Alzheimer Disease") association path(MESH:"Psychotic Disorders") |
| pubmed:24511233 | path(MESH:"Alzheimer Disease") increases path(MESH:Depression) |
| pubmed:26813123 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Depression) |
| pubmed:24511233 | path(MESH:"Alzheimer Disease") increases path(MESH:Anxiety) |
| pubmed:24511233 | path(MESH:"Alzheimer Disease") association bp(MESH:Aging) |
| pubmed:17009926 | path(MESH:"Alzheimer Disease") association p(FPLX:CHRN) |
| pubmed:17009926 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(FPLX:CHRN)) |
| pubmed:17009926 | path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:CHRN) |
| pubmed:17009926 | path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:CHRN) |
| pubmed:25514383 | path(MESH:"Alzheimer Disease") decreases p(FPLX:CHRN) |
| pubmed:11230871 | path(MESH:"Alzheimer Disease") association p(FPLX:CHRN) |
| pubmed:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:CHRN) |
| pubmed:17009926 | path(MESH:"Alzheimer Disease") association complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) |
| pubmed:26813123 | path(MESH:"Alzheimer Disease") increases deg(a(MESH:"Basal Nucleus of Meynert")) |
| pubmed:26813123 | path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"Basal Nucleus of Meynert") |
| pubmed:26813123 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Apathy) |
| pubmed:26813123 | path(MESH:"Alzheimer Disease") negativeCorrelation a(CHEBI:rivastigmine) |
| pubmed:26813123 | path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) |
| pubmed:24590577 | path(MESH:"Alzheimer Disease") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pubmed:19721446 | path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pubmed:25514383 | path(MESH:"Alzheimer Disease") negativeCorrelation a(GO:synapse) |
| pubmed:22908190 | path(MESH:"Alzheimer Disease") negativeCorrelation act(a(GO:synapse)) |
| pubmed:22908190 | path(MESH:"Alzheimer Disease") negativeCorrelation act(a(GO:synapse)) |
| pubmed:25514383 | path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"White Matter") |
| pubmed:26195256 | path(MESH:"Alzheimer Disease") association a(MESH:"White Matter") |
| pubmed:25514383 | path(MESH:"Alzheimer Disease") negativeCorrelation a(HP:"cholinergic neuron") |
| pubmed:25514383 | path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:acetylcholine), p(FPLX:CHRN)) |
| pubmed:25514383 | path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:acetylcholine), p(FPLX:CHRM)) |
| pubmed:25514383 | path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:nicotine), p(FPLX:CHRN)) |
| pubmed:11230871 | path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:nicotine), p(FPLX:CHRN)) |
| pubmed:25514383 | path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:nicotine), p(FPLX:CHRM)) |
| pubmed:25514383 | path(MESH:"Alzheimer Disease") decreases p(FPLX:CHRM) |
| pubmed:25514383 | path(MESH:"Alzheimer Disease") positiveCorrelation complex(p(HGNC:CHRNA7), p(HGNC:FLNA)) |
| pubmed:21718217 | path(MESH:"Alzheimer Disease") positiveCorrelation g(CONSO:CONSO00030) |
| pubmed:21718217 | path(MESH:"Alzheimer Disease") association g(CONSO:CONSO00030) |
| pubmed:21718217 | path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:ARG1) |
| pubmed:21718217 | path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:CHI3L1) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") decreases path(MESH:Memory) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") decreases path(MESH:Cognition) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") association path(MESH:"Behavioral Symptoms") |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") association path(CONSO:aMCI) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") decreases path(MESH:"Cholinergic Neurons") |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") association path(MESH:"Cholinergic Neurons") |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") decreases path(MESH:"Cholinergic Neurons") |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") causesNoChange p(HGNC:SLC18A3) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") increases a(MESH:"pro-nerve growth factor, human") |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") decreases p(HGNC:NTRK1) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") increases p(HGNC:NGF) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") association p(HGNC:SORT1) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") decreases bp(GO:"nerve growth factor processing") |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") increases act(p(HGNC:MMP9)) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") decreases g(HGNC:NTRK1) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") decreases g(HGNC:NTRK2) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") decreases g(HGNC:NTRK3) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") increases g(HGNC:NGFR) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:CHAT) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") increases r(HGNC:CHRNA7) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") increases r(HGNC:CHRNA7) |
| pubmed:11230871 | path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:CHRNA7) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:CHRM1) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") decreases r(HGNC:SYP) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") decreases r(HGNCGENEFAMILY:Synaptotagmins) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:SNAP29) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:APP) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:NOTCH1) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") increases r(HGNC:CTSD) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") decreases r(HGNC:PPP1CA) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") decreases r(HGNC:PPP1CC) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:MAPT) |
| pubmed:18986241 | path(MESH:"Alzheimer Disease") decreases p(CONSO:"3R tau") |
| pubmed:27574109 | path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:"3R tau") |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:"3R tau") |
| pubmed:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation complex(CONSO:"alpha-4-containing nAChR") |
| pubmed:11230871 | path(MESH:"Alzheimer Disease") causesNoChange complex(CONSO:"alpha-7-containing nAChR") |
| pubmed:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation complex(CONSO:"alpha-7-containing nAChR") |
| pubmed:11230871 | path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:CHRNA3) |
| pubmed:11230871 | path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:CHRNA4) |
| pubmed:11230871 | path(MESH:"Alzheimer Disease") decreases complex(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:19721446 | path(MESH:"Alzheimer Disease") decreases a(MESH:Neurons) |
| pubmed:19721446 | path(MESH:"Alzheimer Disease") decreases path(MESH:"Memory, Episodic") |
| pubmed:26837465 | path(MESH:"Alzheimer Disease") increases complex(p(HGNC:ESR1), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) |
| pubmed:28901280 | path(MESH:"Alzheimer Disease") association p(MESH:"Receptors, Nicotinic") |
| pubmed:23178521 | path(MESH:"Alzheimer Disease") increases p(MGI:Il6) |
| pubmed:23178521 | path(MESH:"Alzheimer Disease") increases p(MGI:Tnf) |
| pubmed:23178521 | path(MESH:"Alzheimer Disease") increases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"protein aggregates") |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:ANP32A) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:BAX) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:BCHE) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:BGN) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:BRCA1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:CAPN1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:CCNB1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:CDK1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:CDK2) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:CDKN2A) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:CXCR4) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:EIF4EBP1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:FOLH1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:HOMER1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:HRH1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:IGF2) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:IGFBP2) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:LDLR) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:MAOA) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:NEFH) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:NPDC1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:NRGN) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:PREP) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:PROS1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:PTGS1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:SELENBP1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:TAGLN) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:TGFB1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:TUBB3) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:VKORC1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") decreases g(HGNC:CANX) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") decreases g(HGNC:GCNT2) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") decreases g(HGNC:IDE) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") decreases g(HGNC:MMP1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") decreases g(HGNC:NFE2L2) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") decreases g(HGNC:NR3C1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") decreases g(HGNC:PPARA) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") decreases g(HGNC:SLC6A6) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") decreases g(HGNC:SYVN1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") decreases g(HGNC:TSHZ1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") decreases g(HGNC:TXN) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") decreases g(HGNC:ACLY) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") decreases g(HGNC:ATAD2) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") decreases g(HGNC:BECN1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") decreases g(HGNC:DHCR24) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") decreases g(HGNC:FGF2) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") decreases g(HGNC:HTRA1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") decreases g(HGNC:PRKCE) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") decreases g(HGNC:PRKDC) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") decreases g(HGNC:SCD) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") decreases g(HGNC:TUBB) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") decreases g(HGNC:UNG) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:ATP1A1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:CTSD) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:GLRX) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:GLRX) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:HMOX1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:HMOX1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:IL6R) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:NPTX1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:NQO1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:NQO1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:PHF1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:PRKCD) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:PTGS2) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:RANBP9) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") increases g(HGNC:SOD1) |
| pubmed:22020111 | path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:SOD1) |
| pubmed:30688256 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PSEN1, var("?")) |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") association p(HGNC:PSEN1, var("?")) |
| pubmed:23454242 | path(MESH:"Alzheimer Disease") increases p(HGNC:SET) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SET) |
| pubmed:22299660 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SET) |
| pubmed:23454242 | path(MESH:"Alzheimer Disease") decreases act(p(FPLX:PPP2)) |
| pubmed:22299660 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(FPLX:PPP2)) |
| pubmed:22299660 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(FPLX:PPP2)) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") association p(HGNC:GSK3B) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") association a(MESH:"Receptors, N-Methyl-D-Aspartate") |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") association p(HGNC:GRM5) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") positiveCorrelation complex(GO:"protein phosphatase type 2A complex") |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation g(HGNC:PPP2CA) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CA) |
| pubmed:22299660 | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CA) |
| pubmed:22299660 | path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:PPP2CA) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP2CA) |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:PPP2CA)) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation g(HGNC:PPP2CB) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CB) |
| pubmed:22299660 | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CB) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP2CB) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2R2C) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2R5E) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP2R2A) |
| pubmed:22299660 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP2R2A) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) |
| pubmed:29281045 | path(MESH:"Alzheimer Disease") decreases p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:ANP32A) |
| pubmed:22299660 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:ANP32A) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SET, frag("?")) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PTPA) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:17403556 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:17403556 | path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:22253473 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pubmed:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pubmed:12428809 | path(MESH:"Alzheimer Disease") association a(CONSO:"straight filaments") |
| pubmed:12428809 | path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:"4R tau") |
| pubmed:27574109 | path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:"4R tau") |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:"4R tau") |
| pubmed:12428809 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"axonal transport") |
| pubmed:22908190 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"axonal transport") |
| pubmed:12428809 | path(MESH:"Alzheimer Disease") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:21882945 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:22299660 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 198)) |
| pubmed:23088643 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 198)) |
| pubmed:22299660 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:26458742 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:23088643 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:22299660 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:29191965 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:23088643 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:22299660 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:22419736 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:28420982 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:26458742 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:22299660 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:22419736 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:26458742 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:22299660 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:29191965 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:27373205 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:23088643 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:22299660 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:22299660 | path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2C) |
| pubmed:22299660 | path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2C, pmod(go:0006479 ! "protein methylation", Leu, 309)) |
| pubmed:22299660 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:ICMT) |
| pubmed:22299660 | path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:PPP2C, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) |
| pubmed:21722302 | path(MESH:"Alzheimer Disease") association path(CONSO:Neurodegeneration) |
| pubmed:21722302 | path(MESH:"Alzheimer Disease") association bp(CONSO:"protein aggregation") |
| pubmed:21722302 | path(MESH:"Alzheimer Disease") association path(HP:"Senile plaques") |
| pubmed:21722302 | path(MESH:"Alzheimer Disease") association path(MESH:Neurites) |
| pubmed:21722302 | path(MESH:"Alzheimer Disease") association p(PFAM:Presenilin, var("?")) |
| pubmed:21722302 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:HSPA5) |
| pubmed:21722302 | path(MESH:"Alzheimer Disease") association p(HGNC:XBP1) |
| pubmed:21722302 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:XBP1) |
| pubmed:21722302 | path(MESH:"Alzheimer Disease") decreases bp(MESH:"Unfolded Protein Response") |
| pubmed:21722302 | path(MESH:"Alzheimer Disease") association a(GO:autophagosome) |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") increases a(GO:autophagosome) |
| pubmed:22908190 | path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:autophagosome) |
| pubmed:18930136 | path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:autophagosome) |
| pubmed:18930136 | path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:autophagosome) |
| pubmed:21722302 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:autophagy) |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:autophagy) |
| pubmed:22908190 | path(MESH:"Alzheimer Disease") association bp(GO:autophagy) |
| pubmed:22908190 | path(MESH:"Alzheimer Disease") association bp(GO:autophagy) |
| pubmed:25437566 | path(MESH:"Alzheimer Disease") decreases p(HGNC:HSP90AB1) |
| pubmed:25437566 | path(MESH:"Alzheimer Disease") decreases p(HGNC:HSPA8) |
| pubmed:25437566 | path(MESH:"Alzheimer Disease") decreases p(HGNC:HSPA14) |
| pubmed:25437566 | path(MESH:"Alzheimer Disease") decreases p(HGNC:TCP1) |
| pubmed:27491084 | path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") |
| pubmed:27491084 | path(MESH:"Alzheimer Disease") increases p(HGNC:HSPB1) |
| pubmed:27491084 | path(MESH:"Alzheimer Disease") increases p(HGNC:CRYAB) |
| pubmed:27491084 | path(MESH:"Alzheimer Disease") increases p(FPLX:HSPB) |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy) |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy) |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy) |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy) |
| pubmed:25784053 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy) |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") increases complex(a(CONSO:"dystrophic neurite"), a(GO:autophagosome)) |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:autolysosome) |
| pubmed:23528736 | path(MESH:"Alzheimer Disease") increases a(GO:autolysosome) |
| pubmed:23528736 | path(MESH:"Alzheimer Disease") increases a(GO:autolysosome) |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"lysosomal protein catabolic process") |
| pubmed:22908190 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"lysosomal protein catabolic process") |
| pubmed:23528736 | path(MESH:"Alzheimer Disease") decreases bp(GO:"lysosomal protein catabolic process") |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:BECN1) |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") decreases p(HGNC:BECN1) |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") increases a(GO:lysosome) |
| pubmed:22908190 | path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:lysosome) |
| pubmed:22908190 | path(MESH:"Alzheimer Disease") negativeCorrelation act(a(GO:lysosome)) |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SNCA) |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:endocytosis) |
| pubmed:22908190 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:endocytosis) |
| pubmed:22908190 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:endocytosis) |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") association a(CONSO:"alpha-synuclein aggregates") |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"alpha-synuclein aggregates") |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") association a(CHEBI:sphingolipid) |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:ceramide) |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") association p(HGNC:TFEB) |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") association p(HGNC:PICALM, var("?")) |
| pubmed:26195256 | path(MESH:"Alzheimer Disease") association p(HGNC:PICALM, var("?")) |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") association p(HGNC:VPS35, var("?")) |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") association p(HGNC:SORL1) |
| pubmed:29758300 | path(MESH:"Alzheimer Disease") increases bp(GO:mitophagy) |
| pubmed:14556719 | path(MESH:"Alzheimer Disease") decreases bp(GO:"short-term memory") |
| pubmed:14556719 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:UBA1)) |
| pubmed:14556719 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:UBA2)) |
| pubmed:14556719 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:23528736 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:29626319 | path(MESH:"Alzheimer Disease") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:22908190 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:22908190 | path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:"UBB+1") |
| pubmed:23528736 | path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:"UBB+1") |
| pubmed:22908190 | path(MESH:"Alzheimer Disease") association p(HGNC:UCHL1) |
| pubmed:22908190 | path(MESH:"Alzheimer Disease") association p(HGNC:UBQLN1) |
| pubmed:22908190 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:UBQLN1, var("?")) |
| pubmed:22908190 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RAB7A) |
| pubmed:22908190 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RAB5A) |
| pubmed:22908190 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RAB4A) |
| pubmed:22908190 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"dystrophic neurite") |
| pubmed:22908190 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:APP, var("?")) |
| pubmed:22908190 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:APP, var("?")) |
| pubmed:22908190 | path(MESH:"Alzheimer Disease") association g(CONSO:"APOE e4") |
| pubmed:26195256 | path(MESH:"Alzheimer Disease") positiveCorrelation g(CONSO:"APOE e4") |
| pubmed:25784053 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(FPLX:Proteasome)) |
| pubmed:8282104 | path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:ERK) |
| pubmed:8282104 | path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:GSK3) |
| pubmed:30116051 | path(MESH:"Alzheimer Disease") decreases p(HGNC:SIRT1) |
| pubmed:30116051 | path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:PSEN1, var("?")) |
| pubmed:26195256 | path(MESH:"Alzheimer Disease") association g(HGNC:PSEN1, var("?")) |
| pubmed:30116051 | path(MESH:"Alzheimer Disease") negativeCorrelation a(CHEBI:"selenium(2+)") |
| pubmed:30116051 | path(MESH:"Alzheimer Disease") increases act(p(HGNC:ABL1)) |
| pubmed:30116051 | path(MESH:"Alzheimer Disease") decreases p(HGNC:IDE) |
| pubmed:30116051 | path(MESH:"Alzheimer Disease") decreases p(HGNC:MME) |
| pubmed:30116051 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PLG) |
| pubmed:29024336 | path(MESH:"Alzheimer Disease") increases path(MESH:"Proteostasis Deficiencies") |
| pubmed:29215007 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("?")) |
| pubmed:29980653 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("?")) |
| pubmed:24027553 | path(MESH:"Alzheimer Disease") association p(HGNC:PIN1) |
| pubmed:24027553 | path(MESH:"Alzheimer Disease") increases a(CHEBI:Thrombin, loc(MESH:Microvessels)) |
| pubmed:24027553 | path(MESH:"Alzheimer Disease") increases a(CHEBI:Thrombin, loc(MESH:"Cerebrospinal Fluid")) |
| pubmed:24027553 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:Thrombin, loc(MESH:Neurons)) |
| pubmed:24027553 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:Thrombin, loc(MESH:Astrocytes)) |
| pubmed:24027553 | path(MESH:"Alzheimer Disease") association bp(CONSO:"APP processing") |
| pubmed:24027553 | path(MESH:"Alzheimer Disease") association p(HGNC:HTRA1) |
| pubmed:24027553 | path(MESH:"Alzheimer Disease") increases act(p(HGNC:CAPN2)) |
| pubmed:24027553 | path(MESH:"Alzheimer Disease") positiveCorrelation act(p(HGNC:CASP3)) |
| pubmed:24027553 | path(MESH:"Alzheimer Disease") positiveCorrelation act(p(HGNC:CASP6)) |
| pubmed:24027553 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"proteasomal protein catabolic process") |
| pubmed:24027553 | path(MESH:"Alzheimer Disease") increases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Proteasome)) |
| pubmed:24027553 | path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:Autophagosomes) |
| pubmed:23528736 | path(MESH:"Alzheimer Disease") increases a(MESH:Autophagosomes) |
| pubmed:23528736 | path(MESH:"Alzheimer Disease") increases a(MESH:Autophagosomes) |
| pubmed:24027553 | path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:Lysosomes) |
| pubmed:24027553 | path(MESH:"Alzheimer Disease") decreases bp(MESH:Autophagy) |
| pubmed:27574109 | path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:21734277 | path(MESH:"Alzheimer Disease") increases p(CONSO:"phosphatase-activating domain") |
| pubmed:21734277 | path(MESH:"Alzheimer Disease") increases p(CONSO:"phosphatase-activating domain") |
| pubmed:27574109 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"Tau oligomers") |
| pubmed:27574109 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"Tau oligomers") |
| pubmed:25887395 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"Tau oligomers") |
| pubmed:28420982 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"Tau oligomers") |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"Tau oligomers") |
| pubmed:22817713 | path(MESH:"Alzheimer Disease") increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | path(MESH:"Alzheimer Disease") positiveCorrelation composite(p(CONSO:"phosphatase-activating domain"), p(HGNC:MAPT)) |
| pubmed:23528736 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:UBB) |
| pubmed:23528736 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:UBC) |
| pubmed:23528736 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:UBA52) |
| pubmed:23528736 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RPS27A) |
| pubmed:23528736 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNCGENEFAMILY:"Ubiquitin like modifier activating enzymes") |
| pubmed:23528736 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNCGENEFAMILY:"Ubiquitin conjugating enzymes E2") |
| pubmed:23528736 | path(MESH:"Alzheimer Disease") association p(HGNC:STUB1) |
| pubmed:29311797 | path(MESH:"Alzheimer Disease") association p(HGNC:STUB1) |
| pubmed:23528736 | path(MESH:"Alzheimer Disease") association p(HGNC:PRKN) |
| pubmed:23528736 | path(MESH:"Alzheimer Disease") association p(HGNC:RNF182) |
| pubmed:23528736 | path(MESH:"Alzheimer Disease") association p(HGNC:UCHL1, var("?")) |
| pubmed:23528736 | path(MESH:"Alzheimer Disease") decreases bp(MESH:Proteolysis) |
| pubmed:29988016 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"Tau aggregates") |
| pubmed:27373205 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"Tau aggregates") |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"Tau aggregates") |
| pubmed:22817713 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"Tau aggregates") |
| pubmed:21882945 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:21882945 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:BAG1) |
| pubmed:30126037 | path(MESH:"Alzheimer Disease") association bp(MESH:"Cerebrovascular Circulation") |
| pubmed:22419736 | path(MESH:"Alzheimer Disease") increases p(HGNC:AK1) |
| pubmed:22419736 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:AK1) |
| pubmed:22419736 | path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:AMPK, pmod(go:0006468 ! "protein phosphorylation", Thr, 172)) |
| pubmed:29191965 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:30985105 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:OGT)) |
| pubmed:30985105 | path(MESH:"Alzheimer Disease") decreases p(HGNC:OGT) |
| pubmed:25374103 | path(MESH:"Alzheimer Disease") decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:25374103 | path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(CONSO:misfolded)) |
| pubmed:28420982 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) |
| pubmed:29311797 | path(MESH:"Alzheimer Disease") isA path(MESH:Tauopathies) |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") isA path(MESH:Tauopathies) |
| pubmed:29311797 | path(MESH:"Alzheimer Disease") decreases p(HGNC:PPID) |
| pubmed:29311797 | path(MESH:"Alzheimer Disease") increases p(HGNC:FKBP5) |
| pubmed:29311797 | path(MESH:"Alzheimer Disease") decreases p(HGNC:FKBP4) |
| pubmed:29311797 | path(MESH:"Alzheimer Disease") decreases act(p(HGNC:PPP5C)) |
| pubmed:29311797 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:AHSA1) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 68)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 69)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 71)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 113)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 123)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 153)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 175)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 184)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 185)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 191)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 197)) |
| pubmed:23088643 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 197)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 208)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 210)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 237)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 238)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 258)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 289)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 394)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 403)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 409)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 435)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 427)) |
| pubmed:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 433)) |
| pubmed:26195256 | path(MESH:"Alzheimer Disease") association g(HGNC:PSEN2, var("?")) |
| pubmed:26195256 | path(MESH:"Alzheimer Disease") association g(HGNC:APP, var("?")) |
| pubmed:26195256 | path(MESH:"Alzheimer Disease") association p(HGNC:TREM2, var("?")) |
| pubmed:26195256 | path(MESH:"Alzheimer Disease") association p(HGNC:CLU, var("?")) |
| pubmed:26195256 | path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"Cerebral Cortex") |
| pubmed:26195256 | path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:"Cerebral Ventricles") |
| pubmed:26195256 | path(MESH:"Alzheimer Disease") negativeCorrelation p(MESH:Neprilysin) |
| pubmed:26195256 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MMP2) |
| pubmed:26195256 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:LRP1) |
| pubmed:26195256 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:ABCB1) |
| pubmed:29626319 | path(MESH:"Alzheimer Disease") decreases p(HGNC:ABCB1) |
| pubmed:26195256 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:AGER) |
| pubmed:26195256 | path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"Cerebrospinal Fluid") |
| pubmed:26195256 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:AQP1)) |
| pubmed:26195256 | path(MESH:"Alzheimer Disease") increases path(MESH:"Calcification, Physiologic") |
| pubmed:26195256 | path(MESH:"Alzheimer Disease") increases path(MESH:Fibrosis) |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 259)) |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 290)) |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321)) |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 353)) |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:29276758 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:21427723 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006487 ! "protein N-linked glycosylation")) |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(go:0006493 ! "protein O-linked glycosylation")) |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) |
| pubmed:17050703 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation")) |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, frag("?")) |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, frag("26_230")) |
| pubmed:26631930 | path(MESH:"Alzheimer Disease") increases a(CHEBI:"iron(0)") |
| pubmed:22817713 | path(MESH:"Alzheimer Disease") association a(MESH:"Neuropil Threads") |
| pubmed:29626319 | path(MESH:"Alzheimer Disease") decreases bp(GO:"lysosomal microautophagy") |
| pubmed:29626319 | path(MESH:"Alzheimer Disease") positiveCorrelation act(p(HGNC:ACE)) |
| pubmed:29626319 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:SERPINF2) |
| pubmed:29626319 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:SERPINF2)) |
| pubmed:29626319 | path(MESH:"Alzheimer Disease") decreases tloc(a(CHEBI:water), fromLoc(GO:"extracellular region"), toLoc(MESH:"Cerebrospinal Fluid")) |
| pubmed:25974414 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp13*")) |
| pubmed:25974414 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp25*")) |
| pubmed:25974414 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp368*")) |
| pubmed:25974414 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Glu391*")) |
| pubmed:25974414 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp421*")) |
| pubmed:24869773 | path(MESH:"Alzheimer Disease") association p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 311)) |
| pubmed:23531502 | path(MESH:"Alzheimer Disease") positiveCorrelation act(a(CHEBI:acrolein)) |
| pubmed:19251756 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"canonical glycolysis") |
| pubmed:19251756 | path(MESH:"Alzheimer Disease") negativeCorrelation a(CHEBI:ATP) |
| pubmed:19251756 | path(MESH:"Alzheimer Disease") positiveCorrelation p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation", Tyr, 164)) |
| pubmed:19251756 | path(MESH:"Alzheimer Disease") positiveCorrelation p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation", Tyr, 208)) |
| pubmed:11738469 | path(MESH:"Alzheimer Disease") positiveCorrelation act(p(ECCODE:2.3.2.13)) |
| pubmed:8985134 | path(MESH:"Alzheimer Disease") positiveCorrelation act(p(ECCODE:2.3.2.13)) |
| pubmed:9099822 | path(MESH:"Alzheimer Disease") increases act(p(HGNCGENEFAMILY:Transglutaminases)) |
| pubmed:20096481 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs2651206) |
| pubmed:21548880 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs2651206) |
| pubmed:20096481 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs10807287) |
| pubmed:20096481 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs7764257) |
| pubmed:11943212 | path(MESH:"Alzheimer Disease") positiveCorrelation path(CONSO:"granulovacuolar degeneration") |
| pubmed:23666762 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MARK4) |
| pubmed:23666762 | path(MESH:"Alzheimer Disease") positiveCorrelation complex(p(HGNC:MAPT), p(HGNC:MARK4)) |
| pubmed:28176663 | path(MESH:"Alzheimer Disease") increases r(HGNC:GSK3B) |
| pubmed:26118667 | path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:"CDK5R1 p25") |
| pubmed:21910444 | path(MESH:"Alzheimer Disease") increases p(HGNC:MAPK1) |
| pubmed:21910444 | path(MESH:"Alzheimer Disease") increases p(HGNC:PRKCB) |
| pubmed:24401760 | path(MESH:"Alzheimer Disease") increases p(HGNC:ITPKB) |
| pubmed:24401760 | path(MESH:"Alzheimer Disease") positiveCorrelation path(CONSO:Astrogliosis) |
| pubmed:24401760 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:APP, frag("672_711")) |
| pubmed:29540553 | path(MESH:"Alzheimer Disease") negativeCorrelation p(MGI:Sirt3) |
| pubmed:29559585 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:GAPDH, pmod(go:0017014 ! "protein nitrosylation")) |
| pubmed:21427723 | path(MESH:"Alzheimer Disease") isA path(CONSO:"4R tauopathy") |
| pubmed:19732809 | path(MESH:"Alzheimer Disease") negativeCorrelation p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:19732809 | path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:OGA, var("?")) |
| pubmed:27716675 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SUMO1) |
| pubmed:19765634 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs761059) |
| pubmed:29062069 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MID1) |
| pubmed:25001178 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:DUSP6) |
| pubmed:25001178 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP1CA) |
| pubmed:29281045 | path(MESH:"Alzheimer Disease") decreases p(HGNC:LCMT1) |
| pubmed:29281045 | path(MESH:"Alzheimer Disease") increases p(HGNC:PPME1) |
| pubmed:24964035 | path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:SMAD) |
| pubmed:23157676 | path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:"cis p-tau") |
| pubmed:30837838 | path(MESH:"Alzheimer Disease") association p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) |
| pubmed:30837838 | path(MESH:"Alzheimer Disease") association p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) |
| pubmed:26091809 | path(MESH:"Alzheimer Disease") increases path(MESH:Mortality) |
| pubmed:24561250 | path(MESH:"Alzheimer Disease") association complex(GO:"NLRP3 inflammasome complex") |
| pubmed:24561250 | path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:aging) |
| pubmed:24561250 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PYCARD) |
| pubmed:24561250 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:NLRC4) |
| pubmed:24561250 | path(MESH:"Alzheimer Disease") association complex(GO:"IPAF inflammasome complex") |
| pubmed:27314526 | path(MESH:"Alzheimer Disease") association complex(GO:"inflammasome complex") |
| pubmed:27314526 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:P2RX7) |
| pubmed:25514383 | bp(GO:"neuron cellular homeostasis") association complex(a(CHEBI:amyloid-beta), p(FPLX:CHRN)) |
| pubmed:30988501 | bp(GO:"neuron cellular homeostasis") increases p(HGNCGENEFAMILY:"Purinergic receptors P2X", loc(MESH:Microglia)) |
| pubmed:30988501 | bp(GO:"neuron cellular homeostasis") increases p(HGNCGENEFAMILY:"Glutamate metabotropic receptors", loc(MESH:Microglia)) |
| pubmed:30046111 | bp(GO:aging) decreases bp(GO:"cerebrospinal fluid circulation") |
| pubmed:30046111 | bp(GO:aging) decreases act(a(HP:"interstitial fluid")) |
| pubmed:30046111 | bp(GO:aging) increases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | bp(GO:aging) positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:29421605 | bp(GO:aging) positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:30046111 | bp(GO:aging) decreases act(a(MESH:"Lymphatic Vessels")) |
| pubmed:30046111 | bp(GO:aging) negativeCorrelation act(a(MESH:"Lymphatic Vessels")) |
| pubmed:30046111 | bp(GO:aging) decreases tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:30046111 | bp(GO:aging) association bp(GO:"immune response") |
| pubmed:30046111 | bp(GO:aging) association bp(GO:"inflammatory response") |
| pubmed:30046111 | bp(GO:aging) association bp(GO:"phospholipid metabolic process") |
| pubmed:30046111 | bp(GO:aging) association bp(GO:"extracellular matrix organization") |
| pubmed:30046111 | bp(GO:aging) association bp(GO:"cell adhesion") |
| pubmed:30046111 | bp(GO:aging) association bp(GO:"endothelial tube morphogenesis") |
| pubmed:30046111 | bp(GO:aging) decreases p(MGI:Cdk5r1) |
| pubmed:30046111 | bp(GO:aging) decreases p(MGI:Adamts3) |
| pubmed:30046111 | bp(GO:aging) decreases p(MGI:Fgfr3) |
| pubmed:26551702 | bp(GO:aging) negativeCorrelation a(MESH:Glutathione) |
| pubmed:28760828 | bp(GO:aging) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) |
| pubmed:21427723 | bp(GO:aging) positiveCorrelation p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:25031639 | bp(GO:aging) decreases p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:25031639 | bp(GO:aging) increases p(CONSO:"KXGS motif", pmod(CONSO:hyperphosphorylation)) |
| pubmed:25031639 | bp(GO:aging) decreases p(HGNC:MAPT) |
| pubmed:30145931 | bp(GO:aging) increases p(HGNC:MAPT) |
| pubmed:30145931 | bp(GO:aging) decreases p(HGNC:MAPT) |
| pubmed:21882945 | bp(GO:aging) negativeCorrelation deg(p(HGNC:MAPT)) |
| pubmed:29238289 | bp(GO:aging) increases p(HGNC:MAPT) |
| pubmed:29196815 | bp(GO:aging) increases path(MESH:"Alzheimer Disease") |
| pubmed:24561250 | bp(GO:aging) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29196815 | bp(GO:aging) increases a(CONSO:CONSO00074) |
| pubmed:26979166 | bp(GO:aging) negativeCorrelation bp(GO:"microglial cell mediated cytotoxicity") |
| pubmed:25514383 | bp(GO:aging) association path(MESH:Dementia) |
| pubmed:27522251 | bp(GO:aging) association p(MGI:Chrna7) |
| pubmed:18986241 | bp(GO:aging) increases p(HGNC:NGFR) |
| pubmed:11230871 | bp(GO:aging) negativeCorrelation complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) |
| pubmed:11230871 | bp(GO:aging) negativeCorrelation complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) |
| pubmed:11230871 | bp(GO:aging) causesNoChange r(HGNC:CHRNA3) |
| pubmed:4255369 | bp(GO:aging) positiveCorrelation a(CONSO:"Tau fibrils") |
| pubmed:4255369 | bp(GO:aging) positiveCorrelation a(CONSO:"Tau oligomers") |
| pubmed:31413141 | bp(GO:aging) positiveCorrelation p(HGNC:TREM2, frag("?")) |
| pubmed:23454242 | bp(GO:aging) increases p(HGNC:PPP2R2C) |
| pubmed:23454242 | bp(GO:aging) decreases p(HGNC:PPP2R2B) |
| pubmed:28083634 | bp(GO:aging) increases p(MGI:Otub1) |
| pubmed:27491084 | bp(GO:aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") |
| pubmed:27491084 | bp(GO:aging) decreases p(FPLX:HSPA) |
| pubmed:27491084 | bp(GO:aging) increases p(FPLX:HSPB) |
| pubmed:30562574 | bp(GO:aging) negativeCorrelation p(HGNC:LAMP2) |
| pubmed:30562574 | bp(GO:aging) decreases bp(GO:"chaperone-mediated autophagy") |
| pubmed:30562574 | bp(GO:aging) association bp(GO:"chaperone-mediated autophagy") |
| pubmed:14556719 | bp(GO:aging) negativeCorrelation act(complex(GO:"proteasome complex")) |
| pubmed:22908190 | bp(GO:aging) negativeCorrelation act(complex(GO:"proteasome complex")) |
| pubmed:22908190 | bp(GO:aging) negativeCorrelation act(complex(GO:"proteasome complex")) |
| pubmed:14556719 | bp(GO:aging) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:14556719 | bp(GO:aging) increases p(HGNC:PRNP) |
| pubmed:23746257 | bp(GO:aging) decreases bp(CONSO:Proteostasis) |
| pubmed:23746257 | bp(GO:aging) decreases bp(CONSO:Proteostasis) |
| pubmed:24563850 | bp(GO:aging) positiveCorrelation bp(CONSO:"non-enzymatic protein modification") |
| pubmed:24563850 | bp(GO:aging) association bp(GO:"protein oxidation") |
| pubmed:30116051 | bp(GO:aging) negativeCorrelation act(p(HGNC:SIRT1)) |
| pubmed:30116051 | bp(GO:aging) decreases a(CHEBI:"NAD(+)") |
| pubmed:29024336 | bp(GO:aging) increases path(MESH:"Proteostasis Deficiencies") |
| pubmed:29024336 | bp(GO:aging) increases path(MESH:"Proteostasis Deficiencies") |
| pubmed:21882945 | bp(GO:aging) positiveCorrelation p(HGNC:FKBP5) |
| pubmed:29191965 | bp(GO:aging) decreases bp(GO:locomotion) |
| pubmed:28877763 | bp(GO:aging) increases p(MGI:Syk, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28877763 | bp(GO:aging) increases p(MGI:Syk, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28877763 | bp(GO:aging) increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | bp(GO:aging) positiveCorrelation a(CONSO:"Tau aggregates") |
| pubmed:28877763 | bp(GO:aging) increases p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) |
| pubmed:29626319 | bp(GO:aging) negativeCorrelation p(HGNC:IDE) |
| pubmed:25681682 | bp(GO:aging) negativeCorrelation p(HGNC:AGER) |
| pubmed:19118186 | bp(GO:aging) decreases bp(GO:memory) |
| pubmed:28877763 | bp(GO:aging) increases a(CONSO:"dystrophic neurite") |
| pubmed:29421605 | bp(GO:aging) positiveCorrelation p(RGD:Ptpn1) |
| pubmed:29421605 | bp(GO:aging) negativeCorrelation p(RGD:Irs1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29421605 | bp(GO:aging) negativeCorrelation p(RGD:Akt1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29421605 | bp(GO:aging) negativeCorrelation p(RGD:Gsk3b, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29421605 | bp(GO:aging) negativeCorrelation p(RGD:Mtor, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29421605 | bp(GO:aging) negativeCorrelation p(RGD:Ntrk2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29421605 | bp(GO:aging) positiveCorrelation p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24561250 | bp(GO:aging) increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pubmed:24561250 | bp(GO:aging) increases p(HGNC:IL1B) |
| pubmed:24561250 | bp(GO:aging) increases p(HGNC:IL18) |
| pubmed:30046111 | bp(GO:"cerebrospinal fluid circulation") decreases a(CHEBI:amyloid-beta) |
| pubmed:30046111 | act(a(HP:"interstitial fluid")) decreases a(CHEBI:amyloid-beta) |
| pubmed:30046111 | a(MESH:"Lymphatic Vessels") regulates bp(MESH:Homeostasis) |
| pubmed:30046111 | a(MESH:"Lymphatic Vessels") increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymph Nodes")) |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) association tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Parenchymal Tissue"), toLoc(MESH:"Lymph Nodes")) |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:macromolecule), fromLoc(HP:"interstitial fluid"), toLoc(MESH:"Lymph Nodes")) |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Parenchymal Tissue")) |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) increases bp(MESH:"Cerebrovascular Circulation") |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) increases bp(MESH:"Cerebrovascular Circulation") |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) association bp(MESH:"Cerebrovascular Circulation") |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) positiveCorrelation bp(MESH:"Cerebrovascular Circulation") |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) increases bp(GO:"cerebrospinal fluid secretion") |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:"gadolinium atom"), fromLoc(GO:"extracellular space"), toLoc(MESH:"Cerebrospinal Fluid")) |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) increases bp(GO:"fear response") |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) increases path(MESH:"Spatial Learning") |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) increases path(MESH:"Spatial Learning") |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) increases bp(GO:memory) |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) increases bp(GO:memory) |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) association bp(GO:"gene expression") |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) association path(MESH:"Huntington Disease") |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) association path(MESH:"Parkinson Disease") |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) association path(MESH:"Alzheimer Disease") |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) association bp(GO:"excitatory chemical synaptic transmission") |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) increases bp(GO:learning) |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) increases bp(GO:cognition) |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) association bp(GO:"neuronal signal transduction") |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) regulates a(CHEBI:metabolite) |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) regulates bp(MESH:Glycolysis) |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) regulates bp(GO:"response to oxidative stress") |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) regulates bp(GO:"cellular respiration") |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) negativeCorrelation bp(GO:aging) |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) increases act(p(MGI:Vegfc)) |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) decreases a(CHEBI:amyloid-beta) |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) negativeCorrelation a(CHEBI:amyloid-beta) |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) decreases a(CHEBI:amyloid-beta) |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) decreases a(CHEBI:amyloid-beta) |
| pubmed:30046111 | a(MESH:"Lymphatic Vessels") decreases a(CHEBI:amyloid-beta) |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) decreases bp(GO:"macrophage migration") |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) decreases a(MESH:Macrophages) |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) negativeCorrelation path(MESH:Inflammation) |
| pubmed:30046111 | act(a(MESH:"Lymphatic Vessels")) decreases a(CONSO:CONSO00018) |
| pubmed:30967783 | bp(MESH:Homeostasis) increases a(MESH:Monocytes) |
| pubmed:30967783 | bp(MESH:Homeostasis) increases bp(GO:"microglial cell activation") |
| pubmed:30046111 | tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) association act(a(MESH:"Lymphatic Vessels")) |
| pubmed:30046111 | a(CHEBI:verteporfin) decreases a(MESH:"Lymphatic Vessels") |
| pubmed:30046111 | a(CHEBI:verteporfin) decreases act(a(MESH:"Lymphatic Vessels")) |
| pubmed:30046111 | a(CHEBI:verteporfin) decreases bp(MESH:"Cerebrovascular Circulation") |
| pubmed:30046111 | a(CHEBI:verteporfin) decreases tloc(a(CHEBI:"gadolinium atom"), fromLoc(GO:"extracellular space"), toLoc(MESH:"Cerebrospinal Fluid")) |
| pubmed:30046111 | bp(MESH:"Cerebrovascular Circulation") association act(a(MESH:"Lymphatic Vessels")) |
| pubmed:30046111 | bp(MESH:"Cerebrovascular Circulation") increases act(a(MESH:"Lymphatic Vessels")) |
| pubmed:30046111 | bp(MESH:"Cerebrovascular Circulation") positiveCorrelation act(a(MESH:"Lymphatic Vessels")) |
| pubmed:30046111 | bp(MESH:"Cerebrovascular Circulation") increases tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:30126037 | bp(MESH:"Cerebrovascular Circulation") association p(MGI:Mapt, var("p.Pro301Leu")) |
| pubmed:30126037 | bp(MESH:"Cerebrovascular Circulation") association path(MESH:"Alzheimer Disease") |
| pubmed:30126037 | bp(MESH:"Cerebrovascular Circulation") association path(MESH:"Cognitive Dysfunction") |
| pubmed:30046111 | p(MGI:Aqp4) regulates tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:30046111 | p(MGI:Aqp4) regulates tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Intracellular Space"), toLoc(GO:"extracellular space")) |
| pubmed:30046111 | p(MGI:Aqp4) decreases a(CHEBI:amyloid-beta) |
| pubmed:30046111 | p(MGI:Aqp4) increases bp(GO:cognition) |
| pubmed:27889190 | bp(GO:cognition) association path(DOID:"multiple sclerosis") |
| pubmed:27889190 | bp(GO:cognition) association path(DOID:"acute disseminated encephalomyelitis") |
| pubmed:25031639 | bp(GO:cognition) positiveCorrelation g(HGNC:HDAC6) |
| pubmed:25031639 | bp(GO:cognition) positiveCorrelation a(CHEBI:"epothilone D") |
| pubmed:30270813 | bp(GO:cognition) negativeCorrelation a(CHEBI:cisplatin) |
| pubmed:29661268 | bp(GO:cognition) positiveCorrelation a(CHEBI:"lithium atom") |
| pubmed:22236693 | bp(GO:cognition) negativeCorrelation g(HGNC:NGFR) |
| pubmed:21036197 | bp(GO:cognition) association g(HGNC:NR3C2) |
| pubmed:24586483 | bp(GO:cognition) negativeCorrelation g(DBSNP:rs57095329) |
| pubmed:26235064 | bp(GO:cognition) association p(HGNC:MAPT) |
| pubmed:19126755 | bp(GO:cognition) positiveCorrelation p(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:21482353 | bp(GO:cognition) positiveCorrelation p(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:19126755 | bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA7) |
| pubmed:19126755 | bp(GO:cognition) association act(p(HGNC:CHRNA7)) |
| pubmed:27190210 | bp(GO:cognition) association p(HGNC:CHRNA7) |
| pubmed:19721446 | bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA7) |
| pubmed:19126755 | bp(GO:cognition) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24511233 | bp(GO:cognition) association path(MESH:"Alzheimer Disease") |
| pubmed:11230871 | bp(GO:cognition) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24511233 | bp(GO:cognition) association path(MESH:Schizophrenia) |
| pubmed:19721446 | bp(GO:cognition) association path(MESH:Schizophrenia) |
| pubmed:24511233 | bp(GO:cognition) association a(MESH:Hippocampus) |
| pubmed:24511233 | bp(GO:cognition) association a(MESH:"Cerebral Cortex") |
| pubmed:24511233 | bp(GO:cognition) association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:26813123 | bp(GO:cognition) association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:21482353 | bp(GO:cognition) association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:24511233 | bp(GO:cognition) association p(HGNC:CHRM1) |
| pubmed:24511233 | bp(GO:cognition) association p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") |
| pubmed:24511233 | bp(GO:cognition) association a(MESH:"Prefrontal Cortex") |
| pubmed:27190210 | bp(GO:cognition) association g(HGNC:CHRNA7) |
| pubmed:26813123 | bp(GO:cognition) association bp(GO:"synaptic transmission, glutamatergic") |
| pubmed:30697142 | bp(GO:cognition) positiveCorrelation bp(GO:"synaptic transmission, glutamatergic") |
| pubmed:26813123 | bp(GO:cognition) association a(CHEBI:acetylcholine) |
| pubmed:11230871 | bp(GO:cognition) negativeCorrelation a(CHEBI:acetylcholine) |
| pubmed:25514383 | bp(GO:cognition) association a(HP:"cholinergic neuron") |
| pubmed:30697142 | bp(GO:cognition) positiveCorrelation a(CHEBI:"(-)-cotinine") |
| pubmed:30697142 | bp(GO:cognition) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28445721 | bp(GO:cognition) association p(FPLX:CHRN) |
| pubmed:28445721 | bp(GO:cognition) association p(FPLX:CHRN) |
| pubmed:28445721 | bp(GO:cognition) association p(FPLX:CHRN) |
| pubmed:11230871 | bp(GO:cognition) association p(FPLX:CHRN) |
| pubmed:21482353 | bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA5, var("?")) |
| pubmed:21482353 | bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA3, var("?")) |
| pubmed:21482353 | bp(GO:cognition) positiveCorrelation p(HGNC:CHRNB4, var("?")) |
| pubmed:11230871 | bp(GO:cognition) association complex(a(CHEBI:nicotine), p(FPLX:CHRN)) |
| pubmed:11230871 | bp(GO:cognition) association a(CHEBI:neurotransmitter) |
| pubmed:23516100 | bp(GO:cognition) negativeCorrelation p(HGNC:MAPT, frag("1_421")) |
| pubmed:30108137 | bp(GO:cognition) negativeCorrelation r(HGNC:TFEB) |
| pubmed:22908190 | bp(GO:cognition) positiveCorrelation act(a(GO:synapse)) |
| pubmed:24027553 | bp(GO:cognition) negativeCorrelation p(CONSO:"Tau C3") |
| pubmed:21882945 | bp(GO:cognition) negativeCorrelation path(MESH:Tauopathies) |
| pubmed:21882945 | bp(GO:cognition) positiveCorrelation a(PUBCHEM:134222899) |
| pubmed:21882945 | bp(GO:cognition) positiveCorrelation a(CHEBI:"NMDA receptor antagonist") |
| pubmed:30985105 | bp(GO:cognition) association a(CHEBI:amyloid-beta) |
| pubmed:30988501 | bp(GO:cognition) association bp(MESH:"Immunity, Cellular") |
| pubmed:30988501 | bp(GO:cognition) association bp(MESH:"Immunity, Cellular") |
| pubmed:30988501 | bp(GO:cognition) association path(MESH:"Illness Behavior") |
| pubmed:30988501 | bp(GO:cognition) association path(MESH:Inflammation) |
| pubmed:24808823 | path(MESH:"Spatial Learning") negativeCorrelation p(MGI:Ttbk1) |
| pubmed:24808823 | path(MESH:"Spatial Learning") negativeCorrelation p(MGI:Cdk5) |
| pubmed:24808823 | path(MESH:"Spatial Learning") positiveCorrelation tloc(p(MGI:Grin2b), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) |
| pubmed:24107444 | bp(GO:memory) positiveCorrelation p(MGI:Ncstn) |
| pubmed:29179999 | bp(GO:memory) association a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:29661268 | bp(GO:memory) negativeCorrelation p(HGNC:MAPT, var("p.Lys?Gln")) |
| pubmed:29661268 | bp(GO:memory) negativeCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) |
| pubmed:29661268 | bp(GO:memory) negativeCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281)) |
| pubmed:21673407 | bp(GO:memory) association p(HGNC:HTR4) |
| pubmed:30515821 | bp(GO:memory) positiveCorrelation p(HGNC:DNM1) |
| pubmed:19293145 | bp(GO:memory) association composite(p(HGNC:MAPK1), p(HGNC:MAPK3)) |
| pubmed:24511233 | bp(GO:memory) association a(MESH:Hippocampus) |
| pubmed:24511233 | bp(GO:memory) association a(MESH:Hippocampus) |
| pubmed:19721446 | bp(GO:memory) association a(MESH:Hippocampus) |
| pubmed:24511233 | bp(GO:memory) association a(MESH:"Cerebral Cortex") |
| pubmed:24511233 | bp(GO:memory) association a(MESH:"Cerebral Cortex") |
| pubmed:24511233 | bp(GO:memory) association bp(GO:"long-term synaptic potentiation") |
| pubmed:24511233 | bp(GO:memory) association a(MESH:"Prefrontal Cortex") |
| pubmed:17009926 | bp(GO:memory) association p(FPLX:CHRN) |
| pubmed:11230871 | bp(GO:memory) association p(FPLX:CHRN) |
| pubmed:22530628 | bp(GO:memory) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:26813123 | bp(GO:memory) association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:21482353 | bp(GO:memory) association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:26813123 | bp(GO:memory) positiveCorrelation a(CHEBI:acetylcholine) |
| pubmed:26813123 | bp(GO:memory) association a(CHEBI:acetylcholine) |
| pubmed:26813123 | bp(GO:memory) positiveCorrelation a(MESH:"Cholinergic Neurons") |
| pubmed:26813123 | bp(GO:memory) negativeCorrelation path(CONSO:Neurodegeneration) |
| pubmed:26813123 | bp(GO:memory) association bp(MESH:"Synaptic Transmission") |
| pubmed:26813123 | bp(GO:memory) association p(HGNC:SYP) |
| pubmed:24590577 | bp(GO:memory) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pubmed:24590577 | bp(GO:memory) association p(HGNC:CHRM1) |
| pubmed:19721446 | bp(GO:memory) association p(HGNC:CHRNA7) |
| pubmed:19721446 | bp(GO:memory) association a(MESH:"Entorhinal Cortex") |
| pubmed:23516100 | bp(GO:memory) negativeCorrelation p(HGNC:CTSB) |
| pubmed:30106381 | bp(GO:memory) association p(HGNC:ADNP) |
| pubmed:30012004 | bp(GO:memory) negativeCorrelation path(MESH:"Huntington Disease") |
| pubmed:22908190 | bp(GO:memory) association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:19118186 | bp(GO:memory) negativeCorrelation p(MGI:Mapt) |
| pubmed:28775333 | bp(GO:memory) positiveCorrelation a(CHEBI:"(-)-epigallocatechin 3-gallate") |
| pubmed:28775333 | bp(GO:memory) negativeCorrelation p(MGI:Dyrk1a) |
| pubmed:24355211 | bp(GO:memory) negativeCorrelation p(HGNC:GSK3B) |
| pubmed:27041503 | bp(GO:memory) association p(HGNC:WWC1) |
| pubmed:28771976 | bp(GO:memory) association a(CONSO:RGFP966) |
| pubmed:21843595 | bp(GO:memory) negativeCorrelation p(MGI:Sumo3) |
| pubmed:30046111 | bp(GO:"gene expression") association act(a(MESH:"Lymphatic Vessels")) |
| pubmed:30046111 | path(MESH:"Huntington Disease") association act(a(MESH:"Lymphatic Vessels")) |
| pubmed:30663117 | path(MESH:"Huntington Disease") association path(MESH:Chorea) |
| pubmed:29687724 | path(MESH:"Huntington Disease") association path(MESH:Chorea) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(MESH:Chorea) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(MESH:Chorea) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(MESH:Chorea) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(MESH:Chorea) |
| pubmed:30663117 | path(MESH:"Huntington Disease") association path(MESH:Dementia) |
| pubmed:30012004 | path(MESH:"Huntington Disease") positiveCorrelation path(MESH:Dementia) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(MESH:Dementia) |
| pubmed:30663117 | path(MESH:"Huntington Disease") association path(MESH:"Deglutition Disorders") |
| pubmed:30663117 | path(MESH:"Huntington Disease") association path(MESH:Aphasia) |
| pubmed:30663117 | path(MESH:"Huntington Disease") association path(MESH:Seizures) |
| pubmed:30663117 | path(MESH:"Huntington Disease") association g(HGNC:MIR196A1) |
| pubmed:30663117 | path(MESH:"Huntington Disease") increases g(HGNC:MIR196A1) |
| pubmed:30663117 | path(MESH:"Huntington Disease") association g(HGNC:MIR206) |
| pubmed:30663117 | path(MESH:"Huntington Disease") association g(HGNC:MIR301B) |
| pubmed:30663117 | path(MESH:"Huntington Disease") association g(HGNC:MIR92B) |
| pubmed:30663117 | path(MESH:"Huntington Disease") association g(HGNC:MIR378B) |
| pubmed:30663117 | path(MESH:"Huntington Disease") association g(HGNC:MIR208B) |
| pubmed:30663117 | path(MESH:"Huntington Disease") association g(HGNC:MIR449A) |
| pubmed:30663117 | path(MESH:"Huntington Disease") decreases g(NCBIGENE:406915) |
| pubmed:30663117 | path(MESH:"Huntington Disease") increases g(MIRBASE:hsa-mir-10b) |
| pubmed:30663117 | path(MESH:"Huntington Disease") increases g(HGNC:MIR196B) |
| pubmed:30663117 | path(MESH:"Huntington Disease") increases g(HGNC:MIR615) |
| pubmed:30663117 | path(MESH:"Huntington Disease") increases g(HGNC:MIR1247) |
| pubmed:30663117 | path(MESH:"Huntington Disease") decreases g(MGI:Mir22) |
| pubmed:30663117 | path(MESH:"Huntington Disease") decreases g(MGI:Mir29c) |
| pubmed:30663117 | path(MESH:"Huntington Disease") decreases g(MGI:Mir128-1) |
| pubmed:30663117 | path(MESH:"Huntington Disease") decreases g(MGI:Mir132) |
| pubmed:30663117 | path(MESH:"Huntington Disease") decreases g(MGI:Mir138-1) |
| pubmed:30663117 | path(MESH:"Huntington Disease") decreases g(MGI:Mir218-1) |
| pubmed:30663117 | path(MESH:"Huntington Disease") decreases g(MGI:Mir222) |
| pubmed:30663117 | path(MESH:"Huntington Disease") decreases g(NCBIGENE:723931) |
| pubmed:30663117 | path(MESH:"Huntington Disease") decreases g(NCBIGENE:732489) |
| pubmed:26813123 | path(MESH:"Huntington Disease") negativeCorrelation act(p(HGNC:CHAT)) |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases act(p(HGNC:CHAT)) |
| pubmed:30362565 | path(MESH:"Huntington Disease") association path(MESH:"Neurodegenerative Diseases") |
| pubmed:29687724 | path(MESH:"Huntington Disease") association path(MESH:"Neurodegenerative Diseases") |
| pubmed:30027901 | path(MESH:"Huntington Disease") isA path(MESH:"Neurodegenerative Diseases") |
| pubmed:30362565 | path(MESH:"Huntington Disease") decreases act(p(HGNC:HTT)) |
| pubmed:30362565 | path(MESH:"Huntington Disease") decreases path(MESH:"Organelle Biogenesis") |
| pubmed:30362565 | path(MESH:"Huntington Disease") association path(MESH:Autophagy) |
| pubmed:30362565 | path(MESH:"Huntington Disease") decreases path(MESH:"Mitochondrial Dynamics") |
| pubmed:30362565 | path(MESH:"Huntington Disease") decreases path(MESH:"Protein Transport") |
| pubmed:30362565 | path(MESH:"Huntington Disease") decreases a(CHEBI:ATP) |
| pubmed:30012004 | path(MESH:"Huntington Disease") positiveCorrelation bp(GO:"neuron death") |
| pubmed:30012004 | path(MESH:"Huntington Disease") positiveCorrelation bp(GO:"neuron death") |
| pubmed:27013968 | path(MESH:"Huntington Disease") increases bp(GO:"neuron death") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases bp(GO:"neuron death") |
| pubmed:30012004 | path(MESH:"Huntington Disease") positiveCorrelation path(MESH:Atrophy) |
| pubmed:30012004 | path(MESH:"Huntington Disease") positiveCorrelation path(CONSO:Excitotoxicity) |
| pubmed:30027901 | path(MESH:"Huntington Disease") association path(CONSO:Excitotoxicity) |
| pubmed:30012004 | path(MESH:"Huntington Disease") positiveCorrelation path(MESH:"Oxidative Stress") |
| pubmed:30012004 | path(MESH:"Huntington Disease") negativeCorrelation bp(MESH:"Energy Metabolism") |
| pubmed:30012004 | path(MESH:"Huntington Disease") positiveCorrelation path(CONSO:"mitochondrial dysfunction") |
| pubmed:30012004 | path(MESH:"Huntington Disease") positiveCorrelation path(MESH:Inflammation) |
| pubmed:30012004 | path(MESH:"Huntington Disease") positiveCorrelation bp(GO:"apoptotic process") |
| pubmed:30012004 | path(MESH:"Huntington Disease") positiveCorrelation bp(GO:autophagy) |
| pubmed:30012004 | path(MESH:"Huntington Disease") negativeCorrelation bp(GO:"dopamine metabolic process") |
| pubmed:30012004 | path(MESH:"Huntington Disease") negativeCorrelation bp(GO:"D-glutamate metabolic process") |
| pubmed:30012004 | path(MESH:"Huntington Disease") negativeCorrelation bp(GO:"cannabinoid biosynthetic process") |
| pubmed:30012004 | path(MESH:"Huntington Disease") negativeCorrelation bp(GO:"adenosine catabolic process") |
| pubmed:30012004 | path(MESH:"Huntington Disease") negativeCorrelation a(MESH:"Gray Matter") |
| pubmed:30012004 | path(MESH:"Huntington Disease") negativeCorrelation a(MESH:"White Matter") |
| pubmed:30012004 | path(MESH:"Huntington Disease") negativeCorrelation bp(GO:"motor behavior") |
| pubmed:29687724 | path(MESH:"Huntington Disease") decreases bp(GO:"motor behavior") |
| pubmed:30012004 | path(MESH:"Huntington Disease") negativeCorrelation bp(GO:memory) |
| pubmed:30012004 | path(MESH:"Huntington Disease") negativeCorrelation bp(GO:"psychomotor behavior") |
| pubmed:30012004 | path(MESH:"Huntington Disease") negativeCorrelation bp(GO:"sensory perception") |
| pubmed:30012004 | path(MESH:"Huntington Disease") negativeCorrelation bp(GO:"visual learning") |
| pubmed:29687724 | path(MESH:"Huntington Disease") association path(MESH:Cognition) |
| pubmed:29687724 | path(MESH:"Huntington Disease") decreases bp(GO:behavior) |
| pubmed:29687724 | path(MESH:"Huntington Disease") association path(MESH:Dystonia) |
| pubmed:29687724 | path(MESH:"Huntington Disease") association path(MESH:"Neural Pathways") |
| pubmed:29687724 | path(MESH:"Huntington Disease") association a(CHEBI:dopamine) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases a(CHEBI:dopamine) |
| pubmed:29687724 | path(MESH:"Huntington Disease") association path(MESH:Depression) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(MESH:Depression) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(MESH:Depression) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(MESH:Depression) |
| pubmed:29687724 | path(MESH:"Huntington Disease") association path(MESH:"Motor Disorders") |
| pubmed:29687724 | path(MESH:"Huntington Disease") association path(MESH:"Schizophrenia, Disorganized") |
| pubmed:29687724 | path(MESH:"Huntington Disease") association path(MESH:"Cognitive Dysfunction") |
| pubmed:29687724 | path(MESH:"Huntington Disease") association a(CHEBI:amantadine) |
| pubmed:29687724 | path(MESH:"Huntington Disease") association a(PUBCHEM:9795739) |
| pubmed:27013968 | path(MESH:"Huntington Disease") increases path(HP:"Autosomal dominant inheritance") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(HP:"Autosomal dominant inheritance") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(HP:"Autosomal dominant inheritance") |
| pubmed:27013968 | path(MESH:"Huntington Disease") increases path(MESH:Hyperkinesis) |
| pubmed:27013968 | path(MESH:"Huntington Disease") increases path(HP:"Behavioral abnormality") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(HP:"Behavioral abnormality") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(HP:"Behavioral abnormality") |
| pubmed:27013968 | path(MESH:"Huntington Disease") association p(HGNC:HTT, pmod(HBP:"CAG repeats")) |
| pubmed:27013968 | path(MESH:"Huntington Disease") decreases p(HGNC:BDNF) |
| pubmed:27013968 | path(MESH:"Huntington Disease") causesNoChange p(HGNC:BDNF) |
| pubmed:27013968 | path(MESH:"Huntington Disease") decreases act(p(HGNC:BDNF)) |
| pubmed:27013968 | path(MESH:"Huntington Disease") causesNoChange p(HGNC:BDNF) |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases p(HGNC:BDNF) |
| pubmed:27013968 | path(MESH:"Huntington Disease") decreases p(HGNC:NTRK2) |
| pubmed:27013968 | path(MESH:"Huntington Disease") decreases act(p(HGNC:NTRK2)) |
| pubmed:27013968 | path(MESH:"Huntington Disease") causesNoChange p(HGNC:NTRK2) |
| pubmed:27013968 | path(MESH:"Huntington Disease") causesNoChange p(HGNC:NTRK2) |
| pubmed:27013968 | path(MESH:"Huntington Disease") decreases act(p(HGNC:NTRK2)) |
| pubmed:27013968 | path(MESH:"Huntington Disease") decreases p(HGNC:NTRK2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27013968 | path(MESH:"Huntington Disease") decreases p(HGNC:NTRK2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27013968 | path(MESH:"Huntington Disease") decreases bp(GO:"ERK1 and ERK2 cascade") |
| pubmed:27013968 | path(MESH:"Huntington Disease") decreases bp(GO:"ERK1 and ERK2 cascade") |
| pubmed:27013968 | path(MESH:"Huntington Disease") causesNoChange a(MESH:Neurons) |
| pubmed:27013968 | path(MESH:"Huntington Disease") decreases p(PFAM:DARPP-32) |
| pubmed:27013968 | path(MESH:"Huntington Disease") causesNoChange bp(GO:"maintenance of cell number") |
| pubmed:27013968 | path(MESH:"Huntington Disease") causesNoChange bp(GO:"maintenance of cell number") |
| pubmed:27013968 | path(MESH:"Huntington Disease") causesNoChange p(HGNC:MAPK3) |
| pubmed:27013968 | path(MESH:"Huntington Disease") causesNoChange p(HGNC:MAPK1) |
| pubmed:27013968 | path(MESH:"Huntington Disease") causesNoChange p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27013968 | path(MESH:"Huntington Disease") causesNoChange p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases path(MESH:"Motor Activity") |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases path(MESH:"Motor Activity") |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases path(MESH:"Motor Activity") |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases bp(GO:cognition) |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases bp(GO:cognition) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(HP:Dyskinesia) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(DOID:dystonia) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(DOID:dystonia) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(DOID:dystonia) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(MESH:Anxiety) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(DOID:"sleep disorder") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(HP:"Cognitive impairment") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(HP:"Cognitive impairment") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(HP:"Cognitive impairment") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(MESH:Neuropathology) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(HP:"Atrophy/Degeneration involving the caudate nucleus") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(HP:"Atrophy/Degeneration involving the caudate nucleus") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(HP:"Abnormal putamen morphology") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(HP:"Abnormal putamen morphology") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(HP:"Abnormal putamen morphology") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(MESH:"Suicidal Ideation") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(MESH:"Suicidal Ideation") |
| pubmed:30027901 | path(MESH:"Huntington Disease") association path(MESH:"Westphal disease") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(HP:Bradykinesia) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(HP:"Oculomotor apraxia") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(MESH:"Cognitive Dissonance") |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases bp(GO:"learning or memory") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(MESH:Apathy) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(HP:Irritability) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(HP:"Abnormality of the cerebral subcortex") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(HP:"Sleep disturbance") |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases a(MESH:Neostriatum) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(HP:"Cerebral white matter atrophy") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(HP:"Neuronal loss in the cerebral cortex") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(HP:"Cerebellar atrophy") |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases a(CHEBI:"gamma-aminobutyric acid") |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases a(CHEBI:"gamma-aminobutyric acid") |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases p(HGNC:GAD1) |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases p(HGNC:GAD1) |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases complex(GO:"GABA receptor complex") |
| pubmed:30027901 | path(MESH:"Huntington Disease") causesNoChange complex(GO:"GABA receptor complex") |
| pubmed:30027901 | path(MESH:"Huntington Disease") causesNoChange p(HGNC:TH) |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases r(HGNC:SLC18A2) |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases r(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases p(HGNC:SLC18A3) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases a(CHEBI:serotonin) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases a(MESH:"Hydroxyindoleacetic Acid") |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases p(HGNC:CTH) |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases p(MGI:Cth) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases a(GO:autophagosome) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases r(HGNC:MAP1LC3A) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases r(HGNC:ULK2) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases r(HGNC:LAMP2) |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases r(HGNC:PINK1) |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases r(HGNC:WDFY3) |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases r(HGNC:FKBP1A) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases bp(GO:"mitochondrial fragmentation involved in apoptotic process") |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases composite(a(MESH:Autophagosomes), a(MESH:Mitochondria)) |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases bp(GO:"mRNA transcription") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases bp(GO:"cytokine production involved in inflammatory response") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(HP:"Increased inflammatory response") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases bp(GO:"neuroinflammatory response") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases p(OMIT:0006999) |
| pubmed:30027901 | path(MESH:"Huntington Disease") association p(HGNCGENEFAMILY:"NF-kappa B complex subunits") |
| pubmed:30027901 | path(MESH:"Huntington Disease") association bp(GO:"oxidative phosphorylation") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(NCIT:C19375) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases bp(GO:"regulation of cell cycle") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(MESH:"Movement Disorders") |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(HP:Parkinsonism) |
| pubmed:30027901 | path(MESH:"Huntington Disease") increases path(HP:Agitation) |
| pubmed:30027901 | path(MESH:"Huntington Disease") decreases bp(GO:"energy homeostasis") |
| pubmed:30027901 | path(MESH:"Huntington Disease") association tloc(a(CHEBI:"D-glutamate residue"), fromLoc(GO:cytoplasm), toLoc(GO:"extracellular space")) |
| pubmed:25437566 | path(MESH:"Huntington Disease") decreases p(HGNC:HSP90AB1) |
| pubmed:25437566 | path(MESH:"Huntington Disease") decreases p(HGNC:HSPA8) |
| pubmed:25437566 | path(MESH:"Huntington Disease") decreases p(HGNC:HSPA14) |
| pubmed:25437566 | path(MESH:"Huntington Disease") decreases p(HGNC:TCP1) |
| pubmed:14556719 | path(MESH:"Huntington Disease") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) |
| pubmed:14556719 | path(MESH:"Huntington Disease") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) |
| pubmed:22908190 | path(MESH:"Huntington Disease") positiveCorrelation p(CONSO:"UBB+1") |
| pubmed:25784053 | path(MESH:"Huntington Disease") positiveCorrelation p(FPLX:HSPA) |
| pubmed:25784053 | path(MESH:"Huntington Disease") negativeCorrelation p(HGNC:ATF6) |
| pubmed:18930136 | path(MESH:"Huntington Disease") increases p(HGNC:CTSD) |
| pubmed:18930136 | path(MESH:"Huntington Disease") positiveCorrelation a(GO:autolysosome) |
| pubmed:29024336 | path(MESH:"Huntington Disease") increases path(MESH:"Proteostasis Deficiencies") |
| pubmed:29311797 | path(MESH:"Huntington Disease") association p(HGNC:STUB1) |
| pubmed:30837838 | path(MESH:"Huntington Disease") association p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) |
| pubmed:30837838 | path(MESH:"Huntington Disease") association p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) |
| pubmed:30046111 | path(MESH:"Parkinson Disease") association act(a(MESH:"Lymphatic Vessels")) |
| pubmed:30663117 | path(MESH:"Parkinson Disease") association a(CONSO:"alpha-synuclein aggregates") |
| pubmed:30663117 | path(MESH:"Parkinson Disease") association p(HGNC:SNCA, pmod(CONSO:misfolded)) |
| pubmed:30663117 | path(MESH:"Parkinson Disease") association g(HGNC:MIR132) |
| pubmed:30663117 | path(MESH:"Parkinson Disease") association g(NCBIGENE:406950) |
| pubmed:30663117 | path(MESH:"Parkinson Disease") association p(HGNC:LRRK2) |
| pubmed:30688256 | path(MESH:"Parkinson Disease") association p(HGNC:LRRK2) |
| pubmed:24113872 | path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:LRRK2) |
| pubmed:30663117 | path(MESH:"Parkinson Disease") decreases g(HGNC:MIR205) |
| pubmed:30663117 | path(MESH:"Parkinson Disease") decreases p(HGNC:PARK7) |
| pubmed:30562574 | path(MESH:"Parkinson Disease") association p(HGNC:PARK7) |
| pubmed:30663117 | path(MESH:"Parkinson Disease") increases g(HGNC:MIR494) |
| pubmed:30663117 | path(MESH:"Parkinson Disease") decreases g(HGNC:MIR34B) |
| pubmed:30663117 | path(MESH:"Parkinson Disease") decreases g(HGNC:MIR34C) |
| pubmed:20869593 | path(MESH:"Parkinson Disease") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19126755 | path(MESH:"Parkinson Disease") association p(CONSO:"alpha-6 alpha-4 beta-2 beta-3 nAChR", loc(MESH:"Basal Ganglia")) |
| pubmed:19126755 | path(MESH:"Parkinson Disease") positiveCorrelation path(MESH:Tremor) |
| pubmed:19126755 | path(MESH:"Parkinson Disease") positiveCorrelation path(MESH:Hypokinesia) |
| pubmed:19126755 | path(MESH:"Parkinson Disease") positiveCorrelation path(MESH:"Muscle Rigidity") |
| pubmed:19126755 | path(MESH:"Parkinson Disease") negativeCorrelation path(MESH:"Tobacco Use Disorder") |
| pubmed:17009926 | path(MESH:"Parkinson Disease") negativeCorrelation act(p(FPLX:CHRN)) |
| pubmed:17009926 | path(MESH:"Parkinson Disease") negativeCorrelation p(FPLX:CHRN) |
| pubmed:11230871 | path(MESH:"Parkinson Disease") association p(FPLX:CHRN) |
| pubmed:26813123 | path(MESH:"Parkinson Disease") negativeCorrelation a(MESH:"Cholinergic Neurons") |
| pubmed:24590577 | path(MESH:"Parkinson Disease") association p(HGNC:CHRM4) |
| pubmed:24590577 | path(MESH:"Parkinson Disease") decreases act(a(MESH:"Dopaminergic Neurons")) |
| pubmed:21722302 | path(MESH:"Parkinson Disease") decreases a(MESH:"Dopaminergic Neurons") |
| pubmed:24762290 | path(MESH:"Parkinson Disease") decreases path(MESH:Memory) |
| pubmed:24762290 | path(MESH:"Parkinson Disease") association path(MESH:Memory) |
| pubmed:24762290 | path(MESH:"Parkinson Disease") association complex(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:28901280 | path(MESH:"Parkinson Disease") association p(MESH:"Receptors, Nicotinic") |
| pubmed:22020111 | path(MESH:"Parkinson Disease") positiveCorrelation a(CONSO:"protein aggregates") |
| pubmed:30688256 | path(MESH:"Parkinson Disease") association p(HGNC:PRKN) |
| pubmed:21722302 | path(MESH:"Parkinson Disease") association p(HGNC:PRKN) |
| pubmed:14556719 | path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:PRKN) |
| pubmed:22908190 | path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:PRKN) |
| pubmed:27181519 | path(MESH:"Parkinson Disease") association p(HGNC:PRKN) |
| pubmed:30688256 | path(MESH:"Parkinson Disease") association p(HGNC:PINK1) |
| pubmed:21722302 | path(MESH:"Parkinson Disease") association path(CONSO:Neurodegeneration) |
| pubmed:21722302 | path(MESH:"Parkinson Disease") association bp(CONSO:"protein aggregation") |
| pubmed:21722302 | path(MESH:"Parkinson Disease") association bp(GO:"parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization") |
| pubmed:21722302 | path(MESH:"Parkinson Disease") association p(HGNC:PARK7, var("?")) |
| pubmed:21722302 | path(MESH:"Parkinson Disease") association a(MESH:Paraquat) |
| pubmed:21722302 | path(MESH:"Parkinson Disease") decreases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") |
| pubmed:21722302 | path(MESH:"Parkinson Disease") decreases bp(MESH:"Unfolded Protein Response") |
| pubmed:21722302 | path(MESH:"Parkinson Disease") increases bp(GO:"neuron death") |
| pubmed:14556719 | path(MESH:"Parkinson Disease") positiveCorrelation bp(GO:"neuron death") |
| pubmed:29758300 | path(MESH:"Parkinson Disease") association p(HGNC:VPS35, var("?")) |
| pubmed:29758300 | path(MESH:"Parkinson Disease") negativeCorrelation bp(GO:macroautophagy) |
| pubmed:14556719 | path(MESH:"Parkinson Disease") negativeCorrelation bp(GO:"synaptic transmission, dopaminergic") |
| pubmed:14556719 | path(MESH:"Parkinson Disease") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:14556719 | path(MESH:"Parkinson Disease") association p(HGNC:UCHL1, var("?")) |
| pubmed:14556719 | path(MESH:"Parkinson Disease") association p(HGNC:UCHL1, var("p.Ile93Met")) |
| pubmed:14556719 | path(MESH:"Parkinson Disease") association a(MESH:"Lewy Bodies") |
| pubmed:14556719 | path(MESH:"Parkinson Disease") association p(HGNC:SNCA, var("p.Ala30Pro")) |
| pubmed:14556719 | path(MESH:"Parkinson Disease") association p(HGNC:SNCA, var("p.Ala53Thr")) |
| pubmed:22908190 | path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:SNCA, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:22908190 | path(MESH:"Parkinson Disease") association p(HGNC:UCHL1) |
| pubmed:18930136 | path(MESH:"Parkinson Disease") positiveCorrelation a(GO:autophagosome) |
| pubmed:28803412 | path(MESH:"Parkinson Disease") association p(HGNC:SNCA) |
| pubmed:28803412 | path(MESH:"Parkinson Disease") positiveCorrelation a(CONSO:CONSO00093) |
| pubmed:27075649 | path(MESH:"Parkinson Disease") positiveCorrelation a(CONSO:CONSO00016) |
| pubmed:30116051 | path(MESH:"Parkinson Disease") association p(HGNC:PINK1, var("?")) |
| pubmed:30116051 | path(MESH:"Parkinson Disease") association p(HGNC:PRKN, var("?")) |
| pubmed:30116051 | path(MESH:"Parkinson Disease") association p(HGNC:LRRK2, var("?")) |
| pubmed:29024336 | path(MESH:"Parkinson Disease") increases path(MESH:"Proteostasis Deficiencies") |
| pubmed:30985105 | path(MESH:"Parkinson Disease") positiveCorrelation deg(a(CONSO:"Dopaminergic cell groups")) |
| pubmed:30985105 | path(MESH:"Parkinson Disease") association complex(p(HGNC:SNCA), p(HGNC:SNCA)) |
| pubmed:30985105 | path(MESH:"Parkinson Disease") association act(p(HGNCGENEFAMILY:Calpains)) |
| pubmed:30985105 | path(MESH:"Parkinson Disease") association act(p(HGNCGENEFAMILY:Calpains)) |
| pubmed:29311797 | path(MESH:"Parkinson Disease") association p(HGNC:STUB1) |
| pubmed:26751493 | path(MESH:"Parkinson Disease") association g(DBSNP:rs2471738) |
| pubmed:26751493 | path(MESH:"Parkinson Disease") association g(DBSNP:rs242557) |
| pubmed:26631930 | path(MESH:"Parkinson Disease") increases a(CHEBI:"iron(0)") |
| pubmed:29980653 | path(MESH:"Parkinson Disease") isA path(MESH:"Neurodegenerative Diseases") |
| pubmed:29980653 | path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:SNCA, var("?")) |
| pubmed:29980653 | path(MESH:"Parkinson Disease") isA path(MESH:"Lewy Body Disease") |
| pubmed:30837838 | path(MESH:"Parkinson Disease") association p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) |
| pubmed:30837838 | path(MESH:"Parkinson Disease") association p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) |
| pubmed:30046111 | bp(GO:"excitatory chemical synaptic transmission") association act(a(MESH:"Lymphatic Vessels")) |
| pubmed:29661268 | bp(GO:learning) negativeCorrelation p(HGNC:MAPT, var("p.Lys?Gln")) |
| pubmed:21673407 | bp(GO:learning) association p(HGNC:HTR4) |
| pubmed:19293145 | bp(GO:learning) association path(MESH:"Alzheimer Disease") |
| pubmed:24511233 | bp(GO:learning) association a(MESH:Hippocampus) |
| pubmed:24511233 | bp(GO:learning) association a(MESH:Hippocampus) |
| pubmed:24511233 | bp(GO:learning) association a(MESH:"Cerebral Cortex") |
| pubmed:24511233 | bp(GO:learning) association a(MESH:"Cerebral Cortex") |
| pubmed:24511233 | bp(GO:learning) association bp(GO:"long-term synaptic potentiation") |
| pubmed:24511233 | bp(GO:learning) association a(MESH:"Prefrontal Cortex") |
| pubmed:17009926 | bp(GO:learning) association p(FPLX:CHRN) |
| pubmed:26813123 | bp(GO:learning) association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:26813123 | bp(GO:learning) positiveCorrelation bp(GO:"synaptic transmission, cholinergic") |
| pubmed:21482353 | bp(GO:learning) association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:26813123 | bp(GO:learning) association a(CHEBI:acetylcholine) |
| pubmed:24590577 | bp(GO:learning) association p(HGNC:CHRM1) |
| pubmed:19721446 | bp(GO:learning) association p(HGNC:CHRNA7) |
| pubmed:30106381 | bp(GO:learning) association p(HGNC:ADNP) |
| pubmed:22908190 | bp(GO:learning) association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:24355211 | bp(GO:learning) negativeCorrelation p(HGNC:GSK3B) |
| pubmed:21843595 | bp(GO:learning) negativeCorrelation p(MGI:Sumo3) |
| pubmed:30046111 | bp(GO:"neuronal signal transduction") association act(a(MESH:"Lymphatic Vessels")) |
| pubmed:24590577 | bp(GO:"neuronal signal transduction") association p(HGNC:CHRM1) |
| pubmed:30515821 | bp(MESH:Glycolysis) increases bp(GO:"neuron differentiation") |
| pubmed:30515821 | bp(MESH:Glycolysis) regulates bp(GO:neurogenesis) |
| pubmed:30935091 | bp(GO:"response to oxidative stress") association p(HGNC:HDAC6) |
| pubmed:22110360 | bp(GO:"response to oxidative stress") increases act(p(HGNC:MAP3K5)) |
| pubmed:23092889 | bp(GO:"response to oxidative stress") increases act(complex(GO:"inflammasome complex")) |
| pubmed:24189435 | bp(GO:"response to oxidative stress") association bp(GO:"mitochondrial electron transport, cytochrome c to oxygen") |
| pubmed:23533697 | bp(GO:"response to oxidative stress") decreases a(NIFT:"Cerebral blood flow") |
| pubmed:30515821 | bp(GO:"response to oxidative stress") increases act(p(HGNC:DNM1)) |
| pubmed:11230871 | bp(GO:"response to oxidative stress") negativeCorrelation p(FPLX:CHRN) |
| pubmed:23516100 | bp(GO:"response to oxidative stress") increases tloc(p(HGNC:SNCA), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:23516100 | bp(GO:"response to oxidative stress") increases act(p(HGNCGENEFAMILY:Caspases)) |
| pubmed:27299292 | bp(GO:"response to oxidative stress") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) |
| pubmed:14556719 | bp(GO:"response to oxidative stress") increases p(HGNC:SOD1, pmod(go:0016567 ! "protein ubiquitination"), var("?")) |
| pubmed:14556719 | bp(GO:"response to oxidative stress") increases p(HGNC:SOD1, pmod(CONSO:misfolding), var("?")) |
| pubmed:23746257 | bp(GO:"response to oxidative stress") increases a(MESH:"Heat-Shock Proteins") |
| pubmed:23746257 | bp(GO:"response to oxidative stress") association bp(CONSO:Proteostasis) |
| pubmed:18930136 | bp(GO:"response to oxidative stress") increases p(HGNC:SQSTM1) |
| pubmed:18930136 | bp(GO:"response to oxidative stress") increases r(HGNC:SQSTM1) |
| pubmed:24563850 | bp(GO:"response to oxidative stress") decreases act(p(HGNC:KEAP1)) |
| pubmed:24563850 | bp(GO:"response to oxidative stress") increases p(HGNC:NFE2L2, loc(MESH:"Cell Nucleus")) |
| pubmed:24563850 | bp(GO:"response to oxidative stress") increases act(p(FPLX:PRDX)) |
| pubmed:27671637 | bp(GO:"response to oxidative stress") negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pubmed:23528736 | bp(GO:"response to oxidative stress") increases bp(GO:autophagy) |
| pubmed:22419736 | bp(GO:"response to oxidative stress") increases p(HGNC:AK1) |
| pubmed:26751493 | bp(GO:"response to oxidative stress") association a(CHEBI:"methylene blue") |
| pubmed:26751493 | bp(GO:"response to oxidative stress") association a(CHEBI:"azure A") |
| pubmed:26751493 | bp(GO:"response to oxidative stress") association a(CHEBI:"azure B") |
| pubmed:27181519 | bp(GO:"response to oxidative stress") increases complex(GO:"cytoplasmic stress granule") |
| pubmed:29844403 | bp(GO:"cellular respiration") negativeCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:30126037 | bp(GO:"cellular respiration") association act(a(MESH:Mitochondria)) |
| pubmed:30046111 | bp(GO:"immune response") association bp(GO:aging) |
| pubmed:27288790 | bp(GO:"immune response") association m(MIRBASE:hsa-mir-146a) |
| pubmed:28843454 | bp(GO:"immune response") association p(HGNCGENEFAMILY:"Histocompatibility complex") |
| pubmed:" 26517285" | bp(GO:"immune response") association bp(GO:"microglial cell activation") |
| pubmed:" 26517285" | bp(GO:"immune response") association g(HGNC:CR1) |
| pubmed:" 26517285" | bp(GO:"immune response") association g(HGNC:CD33) |
| pubmed:" 26517285" | bp(GO:"immune response") association g(HGNC:MS4A1) |
| pubmed:" 26517285" | bp(GO:"immune response") association g(HGNC:ABCA7) |
| pubmed:" 26517285" | bp(GO:"immune response") association g(HGNC:CLU) |
| pubmed:" 26517285" | bp(GO:"immune response") association g(HGNC:EPHA1) |
| pubmed:30106381 | bp(GO:"immune response") association p(HGNC:ADNP) |
| pubmed:30106381 | bp(GO:"immune response") association a(PUBCHEM:9832404) |
| pubmed:23746257 | bp(GO:"immune response") association p(FPLX:HSP90) |
| pubmed:30046111 | bp(GO:"inflammatory response") association bp(GO:aging) |
| pubmed:31346362 | bp(GO:"inflammatory response") increases bp(GO:"cell death") |
| pubmed:31346362 | bp(GO:"inflammatory response") increases deg(a(MESH:Tissues)) |
| pubmed:29179999 | bp(GO:"inflammatory response") association act(p(FPLX:NFkappaB)) |
| pubmed:27794524 | bp(GO:"inflammatory response") negativeCorrelation bp(GO:"brain development") |
| pubmed:27794524 | bp(GO:"inflammatory response") positiveCorrelation bp(GO:"central nervous system development") |
| pubmed:27794524 | bp(GO:"inflammatory response") increases path(MESH:"Disease Resistance") |
| pubmed:27794524 | bp(GO:"inflammatory response") positiveCorrelation path(MESH:"Neurodegenerative Diseases") |
| pubmed:27794524 | bp(GO:"inflammatory response") positiveCorrelation path(MESH:Atrophy) |
| pubmed:27794524 | bp(GO:"inflammatory response") positiveCorrelation path(MESH:"Demyelinating Diseases") |
| pubmed:27794524 | bp(GO:"inflammatory response") increases path(MESH:Pathology) |
| pubmed:23533697 | bp(GO:"inflammatory response") association p(HGNC:TREM2) |
| pubmed:27522251 | bp(GO:"inflammatory response") causesNoChange path(MESH:"Memory Disorders") |
| pubmed:21958873 | bp(GO:"inflammatory response") negativeCorrelation a(CHEBI:Anatabine) |
| pubmed:23178521 | bp(GO:"inflammatory response") negativeCorrelation a(CHEBI:Anatabine) |
| pubmed:30740335 | bp(GO:"inflammatory response") increases path(MESH:"Protein Unfolding") |
| pubmed:23746257 | bp(GO:"inflammatory response") association bp(CONSO:Proteostasis) |
| pubmed:24563850 | bp(GO:"inflammatory response") increases a(CHEBI:"reactive oxygen species") |
| pubmed:16566606 | bp(GO:"inflammatory response") increases a(CHEBI:"reactive oxygen species") |
| pubmed:8940412 | bp(GO:"inflammatory response") positiveCorrelation act(p(RGD:Crh)) |
| pubmed:8940412 | bp(GO:"inflammatory response") negativeCorrelation a(CHEBI:antalarmin) |
| pubmed:30126037 | bp(GO:"inflammatory response") association bp(GO:"cellular senescence") |
| pubmed:18494933 | bp(GO:"inflammatory response") increases tloc(p(HGNC:DKK1), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:18494933 | bp(GO:"inflammatory response") positiveCorrelation p(HGNC:S100B) |
| pubmed:16566606 | bp(GO:"inflammatory response") increases a(CHEBI:"reactive nitrogen species") |
| pubmed:16566606 | bp(GO:"inflammatory response") increases a(CHEBI:peroxynitrite) |
| pubmed:30988501 | bp(GO:"inflammatory response") increases bp(GO:"microglial cell activation") |
| pubmed:30988501 | bp(GO:"inflammatory response") increases bp(MESH:"Transendothelial and Transepithelial Migration") |
| pubmed:30988501 | bp(GO:"inflammatory response") increases act(a(MESH:T-Lymphocytes)) |
| pubmed:30046111 | bp(GO:"phospholipid metabolic process") association bp(GO:aging) |
| pubmed:30046111 | bp(GO:"extracellular matrix organization") association bp(GO:aging) |
| pubmed:30046111 | bp(GO:"cell adhesion") association bp(GO:aging) |
| pubmed:21214928 | bp(GO:"cell adhesion") association p(HGNC:APP) |
| pubmed:27190210 | bp(GO:"cell adhesion") association p(HGNC:CHRNA7) |
| pubmed:28901280 | bp(GO:"cell adhesion") association a(MESH:Acetylcholine) |
| pubmed:30106381 | bp(GO:"cell adhesion") association p(HGNC:ADNP) |
| pubmed:30106381 | bp(GO:"cell adhesion") association a(PUBCHEM:9832404) |
| pubmed:30046111 | bp(GO:"endothelial tube morphogenesis") association bp(GO:aging) |
| pubmed:10998059 | act(p(MGI:Cdk5r1)) increases p(MGI:Ppp1r1b, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19118186 | p(MGI:Cdk5r1) increases act(p(MGI:Cdk5)) |
| pubmed:27087442 | p(MGI:Cdk5r1) decreases bp(GO:"neuron death") |
| pubmed:30046111 | p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels") |
| pubmed:30046111 | p(MGI:Vegfc) increases act(a(MESH:"Lymphatic Vessels")) |
| pubmed:30046111 | p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels") |
| pubmed:30046111 | p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels") |
| pubmed:30046111 | p(MGI:Vegfc) increases act(a(MESH:"Lymphatic Vessels")) |
| pubmed:30046111 | p(MGI:Vegfc) causesNoChange a(MESH:"Lymphatic Vessels") |
| pubmed:30046111 | p(MGI:Vegfc) increases path(MESH:"Spatial Learning") |
| pubmed:30046111 | p(MGI:Vegfc) increases bp(GO:"stem cell proliferation") |
| pubmed:30046111 | p(MGI:Vegfc) increases bp(GO:cognition) |
| pubmed:30046111 | p(MGI:Vegfc) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymph Nodes")) |
| pubmed:30046111 | p(MGI:Vegfc) causesNoChange tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymph Nodes")) |
| pubmed:30046111 | p(MGI:Vegfc) causesNoChange a(CHEBI:amyloid-beta) |
| pubmed:30046111 | p(MGI:Vegfc) causesNoChange path(HP:"Abnormal lymphatic vessel morphology") |
| pubmed:30046111 | composite(a(CHEBI:"poly(ethylene glycol dimethacrylate)"), p(MGI:Vegfc)) increases a(MESH:"Lymphatic Vessels") |
| pubmed:30046111 | p(MGI:Vegfc, var("p.Cys156Ser")) increases a(MESH:"Lymphatic Vessels") |
| pubmed:30046111 | p(MGI:Vegfc, var("p.Cys156Ser")) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:Brain)) |
| pubmed:30046111 | path(MESH:Inflammation) negativeCorrelation act(a(MESH:"Lymphatic Vessels")) |
| pubmed:21329555 | path(MESH:Inflammation) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27288790 | path(MESH:Inflammation) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24027553 | path(MESH:Inflammation) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21329555 | path(MESH:Inflammation) association bp(GO:"NIK/NF-kappaB signaling") |
| pubmed:27288790 | path(MESH:Inflammation) association p(FPLX:NFkappaB) |
| pubmed:27794524 | path(MESH:Inflammation) directlyDecreases path(MESH:"Epstein-Barr Virus Infections") |
| pubmed:27794524 | path(MESH:Inflammation) association bp(GO:"microglial cell activation") |
| pubmed:30967783 | path(MESH:Inflammation) increases bp(GO:"microglial cell activation") |
| pubmed:30988501 | path(MESH:Inflammation) increases bp(GO:"microglial cell activation") |
| pubmed:27956442 | path(MESH:Inflammation) association path(MESH:"Multiple Sclerosis") |
| pubmed:27956442 | path(MESH:Inflammation) association path(MESH:"Demyelinating Diseases") |
| pubmed:27956442 | path(MESH:Inflammation) association path(MESH:"Multiple Sclerosis, Relapsing-Remitting") |
| pubmed:27956442 | path(MESH:Inflammation) negativeCorrelation path(MESH:"Energy Metabolism") |
| pubmed:27956442 | path(MESH:Inflammation) directlyIncreases path(NCIT:C95603) |
| pubmed:30967783 | path(MESH:Inflammation) increases act(a(MESH:Microglia, loc(NCIT:C74601))) |
| pubmed:30967783 | path(MESH:Inflammation) increases act(a(MESH:Macrophages, loc(MESH:"Choroid Plexus"))) |
| pubmed:30967783 | path(MESH:Inflammation) increases act(a(MESH:Macrophages, loc(NCIT:C83196))) |
| pubmed:30967783 | path(MESH:Inflammation) increases act(a(MESH:Macrophages, loc(MESH:Meninges))) |
| pubmed:30967783 | path(MESH:Inflammation) association p(HGNC:TREM2) |
| pubmed:30967783 | path(MESH:Inflammation) increases bp(GO:"macrophage activation") |
| pubmed:30967783 | path(MESH:Inflammation) increases path(DOID:"multiple sclerosis") |
| pubmed:27190210 | path(MESH:Inflammation) association p(HGNC:CHRNA7) |
| pubmed:29428175 | path(MESH:Inflammation) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:29428175 | path(MESH:Inflammation) association a(CHEBI:"cholinergic agonist") |
| pubmed:26979166 | path(MESH:Inflammation) increases path(DOID:"mental depression") |
| pubmed:26979166 | path(MESH:Inflammation) association p(HGNC:CHI3L1) |
| pubmed:26979166 | path(MESH:Inflammation) association p(HGNC:CCL2) |
| pubmed:26979166 | path(MESH:Inflammation) increases deg(a(MESH:"Cholinergic Neurons")) |
| pubmed:22040696 | path(MESH:Inflammation) increases path(MESH:"Renal Insufficiency") |
| pubmed:30106381 | path(MESH:Inflammation) association p(HGNC:ADNP) |
| pubmed:30012004 | path(MESH:Inflammation) positiveCorrelation path(MESH:"Huntington Disease") |
| pubmed:24027553 | path(MESH:Inflammation) increases act(p(HGNCGENEFAMILY:Caspases)) |
| pubmed:26195256 | path(MESH:Inflammation) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:26195256 | path(MESH:Inflammation) decreases deg(a(CHEBI:amyloid-beta)) |
| pubmed:30988501 | path(MESH:Inflammation) increases path(CONSO:neurotoxicity) |
| pubmed:30988501 | path(MESH:Inflammation) increases path(CONSO:Neurodegeneration) |
| pubmed:30988501 | path(MESH:Inflammation) decreases bp(GO:cognition) |
| pubmed:30988501 | path(MESH:Inflammation) decreases bp(GO:cognition) |
| pubmed:30988501 | path(MESH:Inflammation) association bp(GO:cognition) |
| pubmed:30988501 | path(MESH:Inflammation) decreases bp(GO:cognition) |
| pubmed:30988501 | path(MESH:Inflammation) increases path(MESH:"Signs and Symptoms") |
| pubmed:30988501 | path(MESH:Inflammation) association path(DOID:obesity) |
| pubmed:30988501 | path(MESH:Inflammation) decreases act(a(MESH:Neurons)) |
| pubmed:30988501 | path(MESH:Inflammation) increases deg(a(MESH:Neurons)) |
| pubmed:30988501 | path(MESH:Inflammation) decreases a(MESH:"Blood-Brain Barrier") |
| pubmed:30988501 | path(MESH:Inflammation) increases act(a(MESH:"Central Nervous System")) |
| pubmed:30988501 | path(MESH:Inflammation) increases path(DOID:"learning disability") |
| pubmed:30988501 | path(MESH:Inflammation) decreases bp(GO:"learning or memory") |
| pubmed:30988501 | path(MESH:Inflammation) decreases path(MESH:Attention) |
| pubmed:30988501 | path(MESH:Inflammation) increases deg(a(GO:"myelin sheath")) |
| pubmed:30988501 | path(MESH:Inflammation) increases path(MESH:Recurrence) |
| pubmed:29255009 | p(MGI:Fkbp1b) increases path(MESH:Memory) |
| pubmed:29255009 | p(MGI:Fkbp1b) increases bp(MESH:Aging) |
| pubmed:29255009 | p(MGI:Fkbp1b) increases act(p(MGI:Eif3g)) |
| pubmed:29255009 | p(MGI:Fkbp1b) increases act(p(MGI:Pla2g7)) |
| pubmed:29255009 | p(MGI:Fkbp1b) increases act(p(MGI:S100b)) |
| pubmed:29255009 | p(MGI:Fkbp1b) increases act(p(MGI:Snapc2)) |
| pubmed:29255009 | p(MGI:Fkbp1b) increases bp(MESH:"Facilitated Diffusion") |
| pubmed:29255009 | p(MGI:Fkbp1b) increases bp(GO:"ectoderm development") |
| pubmed:29255009 | p(MGI:Fkbp1b) increases bp(GO:"regulation of actin cytoskeleton organization") |
| pubmed:29255009 | p(MGI:Fkbp1b) increases act(p(MESH:"Mitogen-Activated Protein Kinases")) |
| pubmed:29255009 | p(MGI:Fkbp1b) decreases act(p(MESH:"Membrane Transport Proteins")) |
| pubmed:29255009 | p(MGI:Fkbp1b) decreases bp(GO:"blood vessel development") |
| pubmed:29255009 | p(MGI:Fkbp1b) decreases bp(GO:"regulation of cellular component movement") |
| pubmed:29255009 | p(MGI:Fkbp1b) decreases a(GO:"cytoplasmic vesicle") |
| pubmed:29255009 | p(MGI:Fkbp1b) increases p(MGI:Map2) |
| pubmed:29255009 | p(MGI:Fkbp1b) negativeCorrelation a(CHEBI:"calcium(2+)") |
| pubmed:29255009 | p(MGI:Fkbp1b) increases p(MGI:Capn1) |
| pubmed:29255009 | p(MGI:Fkbp1b) increases p(MGI:Ppp3cc) |
| pubmed:29255009 | p(MGI:Fkbp1b) increases p(MGI:Orai1) |
| pubmed:29255009 | p(MGI:Fkbp1b) decreases p(MGI:Hif1an) |
| pubmed:29255009 | p(MGI:Fkbp1b) decreases p(MGI:Nfkb1) |
| pubmed:24762290 | path(MESH:Memory) association path(MESH:"Parkinson Disease") |
| pubmed:24762290 | path(MESH:Memory) association complex(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:18986241 | path(MESH:Memory) association path(MESH:"Cholinergic Neurons") |
| pubmed:28901280 | path(MESH:Memory) association p(MESH:"Receptors, Nicotinic") |
| pubmed:29255009 | p(CONSO:AAV-FKBP1B) increases p(MGI:Fkbp1b, loc(MESH:Hippocampus)) |
| pubmed:29255009 | p(CONSO:AAV-FKBP1B) increases g(MGI:Fkbp1b, loc(MESH:Hippocampus)) |
| pubmed:29255009 | bp(MESH:Aging) decreases p(MGI:Map2) |
| pubmed:29255009 | bp(MESH:Aging) decreases p(MGI:Capn1) |
| pubmed:29255009 | bp(MESH:Aging) decreases p(MGI:Ppp3cc) |
| pubmed:29255009 | bp(MESH:Aging) decreases p(MGI:Orai1) |
| pubmed:24511233 | bp(MESH:Aging) association path(MESH:"Alzheimer Disease") |
| pubmed:23528736 | bp(MESH:Aging) increases path(MESH:"Alzheimer Disease") |
| pubmed:25437566 | bp(MESH:Aging) increases p(HGNC:TPR) |
| pubmed:25437566 | bp(MESH:Aging) increases p(HGNC:TPR) |
| pubmed:25437566 | bp(MESH:Aging) increases p(HGNC:TPR) |
| pubmed:27491084 | bp(MESH:Aging) increases p(HGNC:TPR) |
| pubmed:25437566 | bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") |
| pubmed:25437566 | bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") |
| pubmed:25437566 | bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") |
| pubmed:25437566 | bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") |
| pubmed:27491084 | bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") |
| pubmed:25784053 | bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") |
| pubmed:25437566 | bp(MESH:Aging) decreases p(FPLX:HSPA) |
| pubmed:25437566 | bp(MESH:Aging) decreases p(FPLX:HSPA) |
| pubmed:27491084 | bp(MESH:Aging) decreases p(FPLX:HSPA) |
| pubmed:25784053 | bp(MESH:Aging) decreases p(FPLX:HSPA) |
| pubmed:25437566 | bp(MESH:Aging) increases p(FPLX:HSPB) |
| pubmed:25437566 | bp(MESH:Aging) increases p(FPLX:HSPB) |
| pubmed:27491084 | bp(MESH:Aging) increases p(FPLX:HSPB) |
| pubmed:25784053 | bp(MESH:Aging) increases p(FPLX:HSPB) |
| pubmed:25437566 | bp(MESH:Aging) decreases p(HGNC:HSPD1) |
| pubmed:27491084 | bp(MESH:Aging) decreases p(HGNC:HSPD1) |
| pubmed:25437566 | bp(MESH:Aging) increases p(HGNC:HSPA2) |
| pubmed:25437566 | bp(MESH:Aging) increases p(HGNC:DNAJB2) |
| pubmed:25437566 | bp(MESH:Aging) decreases p(HGNC:HSPA12A) |
| pubmed:25437566 | bp(MESH:Aging) decreases p(HGNC:TOMM70) |
| pubmed:25437566 | bp(MESH:Aging) decreases p(HGNC:HSP90AB1) |
| pubmed:25437566 | bp(MESH:Aging) decreases p(HGNC:HSPA8) |
| pubmed:25437566 | bp(MESH:Aging) decreases p(HGNC:HSPA14) |
| pubmed:25437566 | bp(MESH:Aging) decreases p(HGNC:TCP1) |
| pubmed:25784053 | bp(MESH:Aging) regulates bp(CONSO:Proteostasis) |
| pubmed:25784053 | bp(MESH:Aging) decreases p(FPLX:HSP90) |
| pubmed:29311797 | bp(MESH:Aging) increases p(FPLX:HSP90) |
| pubmed:29311797 | bp(MESH:Aging) decreases p(FPLX:HSP90) |
| pubmed:29311797 | bp(MESH:Aging) decreases p(FPLX:HSP90) |
| pubmed:25784053 | bp(MESH:Aging) decreases p(FPLX:"CCT_complex") |
| pubmed:23528736 | bp(MESH:Aging) decreases bp(GO:autophagy) |
| pubmed:23528736 | bp(MESH:Aging) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:28420982 | bp(MESH:Aging) association tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"cell body")) |
| pubmed:28420982 | bp(MESH:Aging) association tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:dendrite)) |
| pubmed:29311797 | bp(MESH:Aging) association path(MESH:"Neurodegenerative Diseases") |
| pubmed:29311797 | bp(MESH:Aging) decreases bp(GO:"protein folding") |
| pubmed:29311797 | bp(MESH:Aging) increases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:29311797 | bp(MESH:Aging) decreases bp(MESH:Proteolysis) |
| pubmed:29311797 | bp(MESH:Aging) decreases act(p(FPLX:Proteasome)) |
| pubmed:29311797 | bp(MESH:Aging) decreases act(p(FPLX:Proteasome)) |
| pubmed:29311797 | bp(MESH:Aging) decreases bp(GO:"chaperone-mediated autophagy") |
| pubmed:29311797 | bp(MESH:Aging) decreases bp(GO:"chaperone-mediated autophagy") |
| pubmed:29311797 | bp(MESH:Aging) decreases p(HGNC:PPID) |
| pubmed:29311797 | bp(MESH:Aging) decreases p(HGNC:PPID) |
| pubmed:29311797 | bp(MESH:Aging) increases p(HGNC:FKBP5) |
| pubmed:29311797 | bp(MESH:Aging) increases p(HGNC:FKBP5) |
| pubmed:29311797 | bp(MESH:Aging) decreases p(HGNC:PPP5C) |
| pubmed:29311797 | bp(MESH:Aging) decreases p(HGNC:PPP5C) |
| pubmed:29311797 | bp(MESH:Aging) decreases p(HGNC:AHSA1) |
| pubmed:29311797 | bp(MESH:Aging) decreases p(HGNC:AHSA1) |
| pubmed:29311797 | bp(MESH:Aging) decreases p(HGNC:FKBP4) |
| pubmed:29311797 | bp(MESH:Aging) decreases p(HGNC:STIP1) |
| pubmed:29311797 | bp(MESH:Aging) decreases p(HGNC:PTGES3) |
| pubmed:29311797 | bp(MESH:Aging) increases p(FPLX:HSP90, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29311797 | bp(MESH:Aging) increases p(FPLX:HSP90, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:29311797 | bp(MESH:Aging) increases p(FPLX:HSP90, pmod(go:0017014 ! "protein nitrosylation")) |
| pubmed:29311797 | bp(MESH:Aging) increases p(FPLX:HSP90, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:29255009 | p(MGI:Eif3g) increases bp(MESH:Aging) |
| pubmed:29255009 | p(MGI:Pla2g7) increases bp(MESH:Aging) |
| pubmed:29255009 | p(MGI:S100b) increases bp(MESH:Aging) |
| pubmed:29255009 | p(MGI:Snapc2) increases bp(MESH:Aging) |
| pubmed:29255009 | path(MESH:Aging) decreases bp(MESH:"Facilitated Diffusion") |
| pubmed:29255009 | path(MESH:Aging) decreases bp(GO:"ectoderm development") |
| pubmed:29255009 | path(MESH:Aging) decreases bp(GO:"regulation of actin cytoskeleton organization") |
| pubmed:29255009 | path(MESH:Aging) decreases act(p(MESH:"Mitogen-Activated Protein Kinases")) |
| pubmed:29255009 | path(MESH:Aging) increases act(p(MESH:"Membrane Transport Proteins")) |
| pubmed:29255009 | path(MESH:Aging) increases bp(GO:"blood vessel development") |
| pubmed:29255009 | path(MESH:Aging) increases bp(GO:"regulation of cellular component movement") |
| pubmed:29255009 | path(MESH:Aging) increases a(GO:"cytoplasmic vesicle") |
| pubmed:29255009 | path(MESH:Aging) increases p(MGI:Hif1an) |
| pubmed:29255009 | path(MESH:Aging) increases p(MGI:Nfkb1) |
| pubmed:27794524 | path(MESH:Aging) decreases path(MESH:Inflammation) |
| pubmed:27794524 | path(MESH:Aging) increases path(MESH:"Neurodegenerative Diseases") |
| pubmed:19126755 | path(MESH:Aging) negativeCorrelation p(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:19126755 | path(MESH:Aging) negativeCorrelation p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19126755 | path(MESH:Aging) decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19126755 | path(MESH:Aging) decreases p(MGI:Chrna4) |
| pubmed:19126755 | path(MESH:Aging) negativeCorrelation p(MGI:Chrna4) |
| pubmed:19126755 | path(MESH:Aging) negativeCorrelation p(MGI:Chrna7) |
| pubmed:18986241 | path(MESH:Aging) association bp(MESH:"Oxidative Stress") |
| pubmed:30362565 | path(MESH:Aging) increases path(MESH:"Motor Skills Disorders") |
| pubmed:30362565 | path(MESH:Aging) increases path(MESH:Ataxia) |
| pubmed:26195256 | path(MESH:Aging) increases path(MESH:"Alzheimer Disease") |
| pubmed:26195256 | path(MESH:Aging) negativeCorrelation a(MESH:"Cerebrospinal Fluid") |
| pubmed:26195256 | path(MESH:Aging) negativeCorrelation act(p(HGNC:AQP1)) |
| pubmed:26091809 | path(MESH:Aging) positiveCorrelation p(HGNC:TARDBP) |
| pubmed:29255009 | a(CHEBI:"calcium(2+)") negativeCorrelation p(MGI:Fkbp1b) |
| pubmed:24107444 | a(CHEBI:"calcium(2+)") positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pubmed:24107444 | a(CHEBI:"calcium(2+)") positiveCorrelation bp(MESH:"Neuronal Plasticity") |
| pubmed:19126755 | a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(MESH:"Neuronal Plasticity") |
| pubmed:29428175 | tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"endoplasmic reticulum"), toLoc(MESH:Cytoplasm)) increases bp(MESH:"Neuronal Plasticity") |
| pubmed:24107444 | a(CHEBI:"calcium(2+)") positiveCorrelation tloc(a(CHEBI:"L-glutamic acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:31346362 | a(CHEBI:"calcium(2+)", loc(MESH:Cytosol)) increases bp(GO:"membrane lipid catabolic process") |
| pubmed:31346362 | a(CHEBI:"calcium(2+)", loc(MESH:Cytosol)) increases act(p(HGNCGENEFAMILY:Calpains)) |
| pubmed:24027553 | a(CHEBI:"calcium(2+)") increases act(p(HGNCGENEFAMILY:Calpains)) |
| pubmed:24027553 | a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases act(p(HGNCGENEFAMILY:Calpains)) |
| pubmed:24027553 | a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases act(p(HGNCGENEFAMILY:Calpains)) |
| pubmed:31346362 | a(CHEBI:"calcium(2+)", loc(MESH:Cytosol)) increases act(p(MESH:Deoxyribonucleases)) |
| pubmed:27794524 | a(CHEBI:"calcium(2+)", loc(GO:axon)) directlyIncreases path(MESH:"Neurodegenerative Diseases") |
| pubmed:27794524 | a(CHEBI:"calcium(2+)", loc(GO:axon)) increases a(MESH:Calpain) |
| pubmed:27794524 | a(CHEBI:"calcium(2+)", loc(GO:axon)) increases a(MESH:Phospholipases) |
| pubmed:27794524 | a(CHEBI:"calcium(2+)", loc(GO:axon)) negativeCorrelation p(MESH:"Microtubule Proteins", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27794524 | a(CHEBI:"calcium(2+)", loc(GO:axon)) negativeCorrelation p(MESH:"Neurofilament Proteins", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19126755 | a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases act(p(FPLX:CREB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:19126755 | a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases a(CHEBI:anandamide) |
| pubmed:19126755 | a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(GO:"signal release") |
| pubmed:19126755 | a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(GO:"neuron migration") |
| pubmed:22040696 | tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Cytoplasm)) increases bp(GO:"neuron migration") |
| pubmed:19126755 | a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(GO:"neuron differentiation") |
| pubmed:19293145 | a(CHEBI:"calcium(2+)") association act(p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors")) |
| pubmed:23038257 | a(CHEBI:"calcium(2+)") increases act(p(MESH:"Receptors, Nicotinic")) |
| pubmed:17009926 | tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(GO:cytosol)) |
| pubmed:26472524 | tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases bp(GO:"membrane depolarization") |
| pubmed:20556492 | a(CHEBI:"calcium(2+)") regulates bp(GO:"membrane depolarization") |
| pubmed:26472524 | a(CHEBI:"calcium(2+)") regulates act(p(FPLX:CHRN)) |
| pubmed:26813123 | a(CHEBI:"calcium(2+)") regulates p(FPLX:CHRN) |
| pubmed:26813123 | a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pubmed:26813123 | a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pubmed:26813123 | a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:dopamine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pubmed:26813123 | a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:serotonin), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pubmed:26813123 | a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:noradrenaline), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pubmed:26813123 | a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pubmed:29428175 | a(CHEBI:"calcium(2+)", loc(MESH:Cytoplasm)) regulates tloc(a(CHEBI:neurotransmitter), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:29428175 | a(CHEBI:"calcium(2+)", loc(MESH:"Endoplasmic Reticulum")) increases p(HGNC:CAMK2A) |
| pubmed:29428175 | a(CHEBI:"calcium(2+)", loc(MESH:"Endoplasmic Reticulum")) increases a(CHEBI:calcineurin) |
| pubmed:29428175 | tloc(a(CHEBI:"calcium(2+)", loc(MESH:"Endoplasmic Reticulum")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) decreases act(p(HGNC:MAPK14)) |
| pubmed:29428175 | tloc(a(CHEBI:"calcium(2+)", loc(MESH:"Endoplasmic Reticulum")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) decreases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:29428175 | tloc(a(CHEBI:"calcium(2+)", loc(MESH:"Endoplasmic Reticulum")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) decreases p(HGNC:NFKB1) |
| pubmed:29428175 | tloc(a(CHEBI:"calcium(2+)", loc(MESH:"Endoplasmic Reticulum")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) decreases p(HGNC:IFNG) |
| pubmed:26088141 | a(CHEBI:"calcium(2+)") association act(a(MESH:"Calcium Channels")) |
| pubmed:19721446 | a(CHEBI:"calcium(2+)") increases act(p(HGNC:CHRNA7)) |
| pubmed:19721446 | a(CHEBI:"calcium(2+)") increases act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:20556492 | a(CHEBI:"calcium(2+)") regulates complex(GO:"mitochondrial permeability transition pore complex") |
| pubmed:26968346 | a(CHEBI:"calcium(2+)", loc(GO:cytoplasm)) increases act(complex(GO:"calcineurin complex")) |
| pubmed:27299292 | tloc(a(CHEBI:"calcium(2+)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) regulates act(p(HGNC:PPP3CA), ma(go:0016791 ! "phosphatase activity")) |
| pubmed:2123288 | a(CHEBI:"calcium(2+)") increases act(p(FPLX:CALM)) |
| pubmed:2833519 | a(CHEBI:"calcium(2+)") increases act(p(HGNC:S100B)) |
| pubmed:10537045 | a(CHEBI:"calcium(2+)") positiveCorrelation complex(p(HGNC:MAPT), p(HGNC:TGM2)) |
| pubmed:30837838 | a(CHEBI:"calcium(2+)") association bp(GO:"neuron fate commitment") |
| pubmed:30837838 | a(CHEBI:"calcium(2+)") association path(MESH:"Nerve Degeneration") |
| pubmed:30837838 | a(CHEBI:"calcium(2+)") increases bp(GO:"neuron death") |
| pubmed:23702978 | a(CHEBI:"calcium(2+)") association p(HGNC:MAP3K7) |
| pubmed:23702978 | tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases act(p(HGNC:NLRP3)) |
| pubmed:19118186 | p(MGI:Capn1) negativeCorrelation p(MGI:Ttbk1) |
| pubmed:29255009 | a(CHEBI:sirolimus) decreases bp(CONSO:"PI3K-Akt signaling pathway") |
| pubmed:29661268 | a(CHEBI:sirolimus) increases p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29661268 | a(CHEBI:sirolimus) negativeCorrelation bp(GO:autophagy) |
| pubmed:30061532 | a(CHEBI:sirolimus) increases bp(GO:autophagy) |
| pubmed:30688256 | a(CHEBI:sirolimus) increases bp(GO:autophagy) |
| pubmed:26968346 | a(CHEBI:sirolimus) positiveCorrelation bp(GO:autophagy) |
| pubmed:29758300 | a(CHEBI:sirolimus) increases bp(GO:autophagy) |
| pubmed:22908190 | a(CHEBI:sirolimus) increases bp(GO:autophagy) |
| pubmed:22908190 | a(CHEBI:sirolimus) increases bp(GO:autophagy) |
| pubmed:18930136 | a(CHEBI:sirolimus) increases bp(GO:autophagy) |
| pubmed:30116051 | a(CHEBI:sirolimus) increases bp(GO:autophagy) |
| pubmed:23528736 | a(CHEBI:sirolimus) increases bp(GO:autophagy) |
| pubmed:29626319 | a(CHEBI:sirolimus) increases bp(GO:autophagy) |
| pubmed:27181519 | a(CHEBI:sirolimus) increases bp(GO:autophagy) |
| pubmed:29661268 | a(CHEBI:sirolimus) negativeCorrelation act(p(HGNC:PPP2CA)) |
| pubmed:30061532 | a(CHEBI:sirolimus) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:30061532 | a(CHEBI:sirolimus) decreases p(HGNC:SNCA, pmod(CONSO:misfolded)) |
| pubmed:30061532 | a(CHEBI:sirolimus) decreases p(HGNC:TARDBP, pmod(CONSO:misfolded)) |
| pubmed:30061532 | a(CHEBI:sirolimus) increases path(MESH:"Interpersonal Relations") |
| pubmed:30061532 | a(CHEBI:sirolimus) increases bp(GO:behavior) |
| pubmed:30061532 | a(CHEBI:sirolimus) decreases act(a(CHEBI:methamphetamine)) |
| pubmed:30061532 | a(CHEBI:sirolimus) decreases path(MESH:"Psychotic Disorders") |
| pubmed:30061532 | a(CHEBI:sirolimus) decreases path(MESH:"Psychotic Disorders") |
| pubmed:30061532 | a(CHEBI:sirolimus) decreases path(MESH:Schizophrenia) |
| pubmed:30688256 | a(CHEBI:sirolimus) decreases path(MESH:"Neurodegenerative Diseases") |
| pubmed:30688256 | a(CHEBI:sirolimus) increases a(HBP:"huntingtin aggregates") |
| pubmed:26968346 | a(CHEBI:sirolimus) decreases p(HGNC:MTOR) |
| pubmed:29758300 | a(CHEBI:sirolimus) decreases act(p(HGNC:MTOR)) |
| pubmed:18930136 | a(CHEBI:sirolimus) decreases act(p(HGNC:MTOR)) |
| pubmed:30985105 | a(CHEBI:sirolimus) decreases act(p(HGNC:MTOR)) |
| pubmed:30837838 | a(CHEBI:sirolimus) decreases p(HGNC:MTOR) |
| pubmed:26968346 | a(CHEBI:sirolimus) increases p(HGNC:TFEB) |
| pubmed:26968346 | a(CHEBI:sirolimus) decreases act(p(HGNC:SNCA, var("?"))) |
| pubmed:26968346 | a(CHEBI:sirolimus) decreases p(CONSO:PrPSc) |
| pubmed:27299292 | a(CHEBI:sirolimus) increases composite(a(CHEBI:sirolimus), p(HGNC:TFEB, frag("?_*"))) |
| pubmed:29758300 | a(CHEBI:sirolimus) increases bp(GO:cognition) |
| pubmed:29758300 | a(CHEBI:sirolimus) decreases a(CHEBI:amyloid-beta) |
| pubmed:29758300 | a(CHEBI:sirolimus) decreases a(CHEBI:amyloid-beta) |
| pubmed:22908190 | a(CHEBI:sirolimus) decreases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | a(CHEBI:sirolimus) decreases a(CHEBI:amyloid-beta) |
| pubmed:29758300 | a(CHEBI:sirolimus) increases bp(GO:macroautophagy) |
| pubmed:29758300 | a(CHEBI:sirolimus) increases bp(GO:macroautophagy) |
| pubmed:26751493 | a(CHEBI:sirolimus) increases bp(GO:macroautophagy) |
| pubmed:29758300 | a(CHEBI:sirolimus) decreases p(HGNC:MAPT) |
| pubmed:23528736 | a(CHEBI:sirolimus) increases deg(p(HGNC:MAPT)) |
| pubmed:29758300 | a(CHEBI:sirolimus) increases bp(GO:"motor behavior") |
| pubmed:27181519 | a(CHEBI:sirolimus) increases bp(GO:"motor behavior") |
| pubmed:22908190 | a(CHEBI:sirolimus) decreases path(MESH:Tauopathies) |
| pubmed:22908190 | a(CHEBI:sirolimus) decreases path(MESH:Tauopathies) |
| pubmed:25784053 | a(CHEBI:sirolimus) decreases act(p(FPLX:mTORC1)) |
| pubmed:25784053 | a(CHEBI:sirolimus) decreases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:25784053 | a(CHEBI:sirolimus) decreases path(MESH:"Huntington Disease") |
| pubmed:18930136 | a(CHEBI:sirolimus) decreases path(MESH:"Huntington Disease") |
| pubmed:25784053 | a(CHEBI:sirolimus) decreases path(MESH:"Machado-Joseph Disease") |
| pubmed:25784053 | a(CHEBI:sirolimus) decreases path(MESH:"Alzheimer Disease") |
| pubmed:25784053 | a(CHEBI:sirolimus) decreases path(MESH:"Parkinson Disease") |
| pubmed:25784053 | a(CHEBI:sirolimus) decreases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:18930136 | a(CHEBI:sirolimus) decreases path(MESH:"Bulbo-Spinal Atrophy, X-Linked") |
| pubmed:27594586 | a(CHEBI:sirolimus) decreases bp(GO:"TOR signaling") |
| pubmed:27594586 | a(CHEBI:sirolimus) increases r(HGNC:MMP9) |
| pubmed:27594586 | a(CHEBI:sirolimus) increases r(HGNC:MMP2) |
| pubmed:30116051 | a(CHEBI:sirolimus) decreases p(HGNC:SNCA) |
| pubmed:30985105 | a(CHEBI:sirolimus) decreases p(HGNC:SNCA) |
| pubmed:27181519 | a(CHEBI:sirolimus) increases deg(p(HGNC:SNCA)) |
| pubmed:30116051 | a(CHEBI:sirolimus) decreases p(HGNC:FUS) |
| pubmed:27181519 | a(CHEBI:sirolimus) decreases p(HGNC:FUS, loc(GO:"cytoplasmic stress granule")) |
| pubmed:30116051 | a(CHEBI:sirolimus) decreases p(HGNC:HTT) |
| pubmed:27181519 | a(CHEBI:sirolimus) increases deg(p(HGNC:HTT)) |
| pubmed:24027553 | a(CHEBI:sirolimus) increases bp(MESH:Autophagy) |
| pubmed:29626319 | a(CHEBI:sirolimus) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27181519 | a(CHEBI:sirolimus) increases deg(complex(GO:"cytoplasmic stress granule")) |
| pubmed:27181519 | a(CHEBI:sirolimus) increases bp(GO:locomotion) |
| pubmed:27181519 | a(CHEBI:sirolimus) increases a(MESH:Neurites) |
| pubmed:27181519 | a(CHEBI:sirolimus) decreases bp(GO:"cell death") |
| pubmed:30837838 | a(CHEBI:sirolimus) increases path(MESH:Autophagy) |
| pubmed:30837838 | a(CHEBI:sirolimus) increases bp(GO:"autophagosome assembly") |
| pubmed:30837838 | a(CHEBI:sirolimus) increases path(MESH:Proteolysis) |
| pubmed:30837838 | a(CHEBI:sirolimus) increases path(MESH:Memory) |
| pubmed:30837838 | a(CHEBI:sirolimus) increases path(MESH:"Motor Activity") |
| pubmed:30837838 | a(CHEBI:sirolimus) decreases p(HGNC:CASP3) |
| pubmed:30837838 | a(CHEBI:sirolimus) decreases p(HGNC:TARDBP, loc(GO:cytoplasm)) |
| pubmed:29255009 | bp(CONSO:"PI3K-Akt signaling pathway") causesNoChange act(p(MGI:Fkbp1b)) |
| pubmed:28745240 | bp(CONSO:"PI3K-Akt signaling pathway") increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | bp(CONSO:"PI3K-Akt signaling pathway") increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:31248781 | bp(CONSO:"PI3K-Akt signaling pathway") association p(HGNC:CREBBP) |
| pubmed:31248781 | bp(CONSO:"PI3K-Akt signaling pathway") association bp(MESH:Neuroprotection) |
| pubmed:29255009 | act(complex(a(CHEBI:sirolimus), p(MGI:Fkbp1b))) decreases bp(CONSO:"PI3K-Akt signaling pathway") |
| pubmed:29255009 | act(complex(a(CHEBI:sirolimus), p(MGI:Fkbp1a))) decreases bp(CONSO:"PI3K-Akt signaling pathway") |
| pubmed:29255009 | p(MGI:Fkbp1a) decreases bp(CONSO:"PI3K-Akt signaling pathway") |
| pubmed:30126037 | act(p(MGI:Nfkb1)) increases bp(MESH:"Cell Survival") |
| pubmed:30126037 | act(p(MGI:Nfkb1)) increases bp(GO:"inflammatory response") |
| pubmed:30663117 | r(HGNC:BACE1, loc(GO:cytoplasm)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:30663117 | r(HGNC:BACE1) increases path(MESH:"Alzheimer Disease") |
| pubmed:21329555 | r(HGNC:BACE1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29179999 | r(HGNC:BACE1) association act(p(FPLX:NFkappaB)) |
| pubmed:27288790 | r(HGNC:BACE1) decreases p(HGNC:UCHL1) |
| pubmed:27288790 | r(HGNC:BACE1) decreases act(p(HGNC:UCHL1)) |
| pubmed:30663117 | r(HGNC:BACE1-AS) biomarkerFor path(MESH:"Alzheimer Disease") |
| pubmed:30663117 | r(HGNC:BACE1-AS) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:30663117 | r(HGNC:BACE1-AS) increases r(HGNC:BACE1) |
| pubmed:27288790 | r(HGNC:BACE1-AS) regulates r(HGNC:BACE1) |
| pubmed:27288790 | r(HGNC:BACE1-AS) decreases deg(r(HGNC:BACE1)) |
| pubmed:30663117 | r(HGNC:BACE1-AS) increases a(CHEBI:amyloid-beta) |
| pubmed:30663117 | r(HGNC:BACE1-AS) increases path(MESH:"Plaque, Amyloid") |
| pubmed:27288790 | r(HGNC:BACE1-AS) regulates p(HGNC:BACE1) |
| pubmed:27288790 | r(HGNC:BACE1-AS) increases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:25652642 | path(MESH:"Plaque, Amyloid") positiveCorrelation act(complex(GO:"NF-kappaB complex")) |
| pubmed:25652642 | path(MESH:"Plaque, Amyloid") association complex(GO:"NF-kappaB complex") |
| pubmed:25652642 | path(MESH:"Plaque, Amyloid") association a(MESH:"HLA-DR Antigens") |
| pubmed:29196815 | path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19126755 | path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19293145 | path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19293145 | path(MESH:"Plaque, Amyloid") biomarkerFor path(MESH:"Alzheimer Disease") |
| pubmed:19293145 | path(MESH:"Plaque, Amyloid") association path(MESH:"Alzheimer Disease") |
| pubmed:24511233 | path(MESH:"Plaque, Amyloid") biomarkerFor path(MESH:"Alzheimer Disease") |
| pubmed:24590577 | path(MESH:"Plaque, Amyloid") association path(MESH:"Alzheimer Disease") |
| pubmed:25514383 | path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22817713 | path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21871088 | path(MESH:"Plaque, Amyloid") increases bp(GO:"microglial cell activation") |
| pubmed:19293145 | path(MESH:"Plaque, Amyloid") association p(HGNC:CHRNA7) |
| pubmed:19293145 | path(MESH:"Plaque, Amyloid") causesNoChange r(HGNC:CHRNA4) |
| pubmed:19293145 | path(MESH:"Plaque, Amyloid") causesNoChange r(HGNC:CHRNA7) |
| pubmed:24511233 | path(MESH:"Plaque, Amyloid") association a(CONSO:"amyloid-beta aggregates") |
| pubmed:26195256 | path(MESH:"Plaque, Amyloid") association a(CONSO:"amyloid-beta aggregates") |
| pubmed:24511233 | path(MESH:"Plaque, Amyloid") increases path(CONSO:neuroinflammation) |
| pubmed:24511233 | path(MESH:"Plaque, Amyloid") increases bp(GO:"cell death") |
| pubmed:24590577 | path(MESH:"Plaque, Amyloid") association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:25514383 | path(MESH:"Plaque, Amyloid") association complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) |
| pubmed:18986241 | path(MESH:"Plaque, Amyloid") association p(HGNC:BCHE) |
| pubmed:18986241 | path(MESH:"Plaque, Amyloid") association p(HGNC:ACHE) |
| pubmed:26010758 | path(MESH:"Plaque, Amyloid") association p(FPLX:NFkappaB, pmod(go:0006468 ! "protein phosphorylation", Ser, 536)) |
| pubmed:27299292 | path(MESH:"Plaque, Amyloid") negativeCorrelation p(HGNC:TFEB) |
| pubmed:14556719 | path(MESH:"Plaque, Amyloid") association a(MESH:"Amyloid beta-Peptides") |
| pubmed:24027553 | path(MESH:"Plaque, Amyloid") association p(HGNC:MAP1LC3A) |
| pubmed:28420982 | path(MESH:"Plaque, Amyloid") association a(MESH:Exosomes) |
| pubmed:26195256 | path(MESH:"Plaque, Amyloid") negativeCorrelation act(p(HGNC:MMP2)) |
| pubmed:26195256 | path(MESH:"Plaque, Amyloid") increases act(a(MESH:Astrocytes)) |
| pubmed:18562203 | path(MESH:"Plaque, Amyloid") association act(a(MESH:Astrocytes)) |
| pubmed:23531502 | path(MESH:"Plaque, Amyloid") association act(a(CHEBI:acrolein)) |
| pubmed:18562203 | path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) |
| pubmed:26400044 | path(MESH:"Plaque, Amyloid") association complex(p(MGI:Dpysl2, pmod(go:0006468 ! "protein phosphorylation")), p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")), p(MGI:Wasf1, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:23088643 | path(MESH:"Plaque, Amyloid") association p(CONSO:"Tau epitope, AT8") |
| pubmed:28877763 | path(MESH:"Plaque, Amyloid") association a(CONSO:"dystrophic neurite") |
| pubmed:24401760 | path(MESH:"Plaque, Amyloid") association a(CONSO:"dystrophic neurite") |
| pubmed:28877763 | path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:SYK, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24401760 | path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:ITPKB) |
| pubmed:30988501 | path(MESH:"Plaque, Amyloid") association a(MESH:"Herpesvirus 1, Human") |
| pubmed:30663117 | g(HGNC:MIR124-1) decreases p(HGNC:BACE1) |
| pubmed:10656250 | p(HGNC:BACE1) increases tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:24590577 | p(HGNC:BACE1) increases p(CONSO:sAPP-beta) |
| pubmed:10656250 | p(HGNC:BACE1) causesNoChange tloc(p(CONSO:sAPP-alpha), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:10656250 | p(HGNC:BACE1) causesNoChange p(HGNC:APP) |
| pubmed:10656250 | p(HGNC:BACE1, loc(GO:"endoplasmic reticulum")) association p(HGNC:APP, loc(GO:"endoplasmic reticulum")) |
| pubmed:24590577 | p(HGNC:BACE1) increases deg(p(HGNC:APP)) |
| pubmed:21718217 | p(HGNC:BACE1) decreases p(HGNC:APP) |
| pubmed:10656250 | p(HGNC:BACE1) increases p(HGNC:APP, frag("672_770")) |
| pubmed:10656250 | p(HGNC:BACE1) association p(CONSO:APP695) |
| pubmed:10656250 | p(HGNC:BACE1) association p(CONSO:APP751) |
| pubmed:30444369 | p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta polypeptide 42"), p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments"))) |
| pubmed:18650430 | act(p(HGNC:BACE1), ma(go:0008233 ! "peptidase activity")) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("11_*")), p(HGNC:APP, frag("1_10")))) |
| pubmed:21214928 | p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) |
| pubmed:21214928 | p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) |
| pubmed:21214928 | p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) |
| pubmed:22122372 | p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) |
| pubmed:21722302 | p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) |
| pubmed:21214928 | p(HGNC:BACE1) increases bp(GO:"neuron death") |
| pubmed:21214928 | p(HGNC:BACE1) decreases bp(GO:"synaptic transmission, cholinergic") |
| pubmed:21214928 | p(HGNC:BACE1) decreases bp(GO:memory) |
| pubmed:21214928 | p(HGNC:BACE1) increases p(HGNC:APP, frag("672_713")) |
| pubmed:21214928 | p(HGNC:BACE1) increases p(HGNC:APP, frag("672_711")) |
| pubmed:22122372 | p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00042), p(CONSO:CONSO00081))) |
| pubmed:22122372 | p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00042), p(CONSO:CONSO00081))) |
| pubmed:22122372 | p(HGNC:BACE1) increases a(CHEBI:amyloid-beta) |
| pubmed:18986241 | act(p(HGNC:BACE1)) increases a(CHEBI:amyloid-beta) |
| pubmed:25331948 | p(HGNC:BACE1) increases a(CHEBI:amyloid-beta) |
| pubmed:26195256 | act(p(HGNC:BACE1)) increases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | p(HGNC:BACE1) increases a(CHEBI:amyloid-beta) |
| pubmed:19126755 | p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:24590577 | p(HGNC:BACE1) increases p(CONSO:C99) |
| pubmed:21718217 | p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta polypeptide 40") |
| pubmed:23516100 | p(HGNC:BACE1) association act(p(HGNCGENEFAMILY:Calpains)) |
| pubmed:23516100 | act(p(HGNC:BACE1)) increases p(HGNC:APP, frag("?")) |
| pubmed:23516100 | act(p(HGNC:BACE1)) increases p(HGNC:APP, frag("?"), loc(GO:"secretory vesicle")) |
| pubmed:29758300 | p(HGNC:BACE1) increases p(HGNC:APP, frag("?")) |
| pubmed:14556719 | p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta polypeptide 40"), a(CHEBI:"amyloid-beta polypeptide 42"))) |
| pubmed:30663117 | complex(g(HGNC:MIR124-1), r(HGNC:BACE1)) decreases act(r(HGNC:BACE1)) |
| pubmed:30663117 | complex(g(HGNC:MIR15B), r(HGNC:BACE1)) decreases p(HGNC:BACE1) |
| pubmed:30663117 | complex(g(HGNC:MIR339), r(HGNC:BACE1)) decreases p(HGNC:BACE1) |
| pubmed:30663117 | complex(g(HGNC:MIR384), r(HGNC:BACE1)) decreases p(HGNC:BACE1) |
| pubmed:30663117 | g(HGNC:MIR384) association path(MESH:"Alzheimer Disease") |
| pubmed:30663117 | complex(g(HGNC:MIR384), r(HGNC:APP)) decreases p(HGNC:APP) |
| pubmed:24107444 | p(HGNC:APP) association complex(GO:"gamma-secretase complex") |
| pubmed:24883238 | p(HGNC:APP) association p(HGNC:STK11) |
| pubmed:24883238 | p(HGNC:APP) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:17234589 | p(HGNC:APP) association p(FB:Lkb1) |
| pubmed:31346362 | p(HGNC:APP) increases path(DOID:"Alzheimer's disease") |
| pubmed:30232325 | p(HGNC:APP) increases act(p(HGNC:WNT3A)) |
| pubmed:30232325 | p(HGNC:APP) increases act(p(HGNC:WNT5A)) |
| pubmed:30232325 | p(HGNC:APP) increases bp(GO:"canonical Wnt signaling pathway") |
| pubmed:30232325 | p(HGNC:APP) increases bp(GO:"non-canonical Wnt signaling pathway") |
| pubmed:11230871 | act(p(HGNC:APP)) association p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) |
| pubmed:30232325 | p(HGNC:APP) increases act(p(HGNC:DKK1)) |
| pubmed:30232325 | p(HGNC:APP) increases act(p(HGNC:DKK1)) |
| pubmed:30232325 | p(HGNC:APP) increases path(CONSO:CONSO00061) |
| pubmed:10656250 | p(HGNC:APP, loc(GO:"endoplasmic reticulum")) association p(HGNC:BACE1, loc(GO:"endoplasmic reticulum")) |
| pubmed:21034527 | p(HGNC:APP) regulates p(HGNC:BACE1) |
| pubmed:21034527 | act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(HGNC:BACE1)) |
| pubmed:18650430 | p(HGNC:APP) increases bp(GO:"regulation of cell growth") |
| pubmed:18650430 | p(HGNC:APP) increases bp(GO:"synapse assembly") |
| pubmed:21214928 | p(HGNC:APP) association bp(GO:"synapse assembly") |
| pubmed:18650430 | p(HGNC:APP) increases bp(MESH:"Neuronal Outgrowth") |
| pubmed:21214928 | p(HGNC:APP) association bp(MESH:"Neuronal Outgrowth") |
| pubmed:18650430 | p(HGNC:APP) increases bp(GO:"cell adhesion") |
| pubmed:21214928 | p(HGNC:APP) association bp(GO:"cell adhesion") |
| pubmed:22122372 | p(HGNC:APP) increases bp(GO:"cell adhesion") |
| pubmed:18650430 | p(HGNC:APP) regulates act(p(HGNC:SLC5A7)) |
| pubmed:21214928 | p(HGNC:APP) increases a(CHEBI:amyloid-beta) |
| pubmed:22122372 | p(HGNC:APP) increases a(CHEBI:amyloid-beta) |
| pubmed:26027813 | p(HGNC:APP) increases a(CHEBI:amyloid-beta) |
| pubmed:21722302 | p(HGNC:APP) increases a(CHEBI:amyloid-beta) |
| pubmed:18930136 | deg(p(HGNC:APP)) association a(CHEBI:amyloid-beta) |
| pubmed:21214928 | p(HGNC:APP) association bp(GO:"signal transduction") |
| pubmed:21214928 | p(HGNC:APP) association bp(GO:"calcium ion homeostasis") |
| pubmed:21214928 | p(HGNC:APP) association bp(GO:"protein transport") |
| pubmed:21214928 | p(HGNC:APP) regulates bp(GO:"protein transport") |
| pubmed:21214928 | p(HGNC:APP) association p(HGNC:ITGB1) |
| pubmed:21214928 | p(HGNC:APP) association bp(GO:"anterograde axonal protein transport") |
| pubmed:21156028 | deg(p(HGNC:APP)) increases p(HGNC:APP, frag("672_713")) |
| pubmed:26996954 | p(HGNC:APP) decreases p(HGNC:APP, frag("672_713")) |
| pubmed:21156028 | deg(p(HGNC:APP)) increases p(HGNC:APP, frag("672_711")) |
| pubmed:22122372 | p(HGNC:APP) increases a(MESH:"Amyloid beta-Peptides") |
| pubmed:29758300 | p(HGNC:APP) increases a(MESH:"Amyloid beta-Peptides") |
| pubmed:14556719 | p(HGNC:APP) increases a(MESH:"Amyloid beta-Peptides") |
| pubmed:22122372 | p(HGNC:APP) association p(CONSO:CONSO00078) |
| pubmed:22122372 | p(HGNC:APP) association p(CONSO:CONSO00079) |
| pubmed:22122372 | p(HGNC:APP) association a(MESH:"Receptors, Cell Surface") |
| pubmed:21034527 | p(HGNC:APP) regulates p(HGNC:APP) |
| pubmed:21034527 | act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(HGNC:APP)) |
| pubmed:21034527 | p(HGNC:APP) regulates p(HGNC:KAT5) |
| pubmed:21034527 | act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(HGNC:KAT5)) |
| pubmed:21034527 | p(HGNC:APP) regulates p(HGNC:GSK3B) |
| pubmed:21034527 | act(p(HGNC:APP)) increases act(p(HGNC:GSK3B)) |
| pubmed:26968346 | deg(p(HGNC:APP)) decreases p(HGNC:GSK3B) |
| pubmed:21034527 | p(HGNC:APP) regulates p(HGNC:TP53) |
| pubmed:21034527 | act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(HGNC:TP53)) |
| pubmed:21034527 | p(HGNC:APP) regulates p(HGNC:SOD2) |
| pubmed:21034527 | act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(HGNC:SOD2)) |
| pubmed:21034527 | p(HGNC:APP) regulates p(HGNC:CD82) |
| pubmed:21034527 | act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(HGNC:CD82)) |
| pubmed:21034527 | p(HGNC:APP) regulates p(HGNC:MME) |
| pubmed:21034527 | p(HGNC:APP) regulates p(HGNC:TAGLN) |
| pubmed:21034527 | act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(HGNC:TAGLN)) |
| pubmed:21034527 | p(HGNC:APP) regulates p(HGNC:ACTA2) |
| pubmed:21034527 | act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(HGNC:ACTA2)) |
| pubmed:21034527 | p(HGNC:APP) regulates p(HGNC:S100A9) |
| pubmed:21034527 | act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(HGNC:S100A9)) |
| pubmed:22110360 | p(HGNC:APP) association p(HGNC:DYRK1A) |
| pubmed:21034527 | act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) association p(INTERPRO:"Amyloidogenic glycoprotein, intracellular domain, conserved site") |
| pubmed:21034527 | act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(HGNC:BACE2)) |
| pubmed:21034527 | act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(HGNC:MMEL1)) |
| pubmed:19926167 | deg(p(HGNC:APP)) association p(HGNC:CTSD) |
| pubmed:25570489 | p(HGNC:APP) association a(NIFT:"Cerebral atrophy") |
| pubmed:20100581 | p(HGNC:APP) association bp(HP:Neurodegeneration) |
| pubmed:25678559 | p(HGNC:APP) increases a(NIFT:"Hippocampal Formation") |
| pubmed:25678559 | p(HGNC:APP) negativeCorrelation a(NIFT:"Hippocampus volume") |
| pubmed:25678559 | p(HGNC:APP) negativeCorrelation a(NIFT:"Mini mental state exam") |
| pubmed:25678559 | p(HGNC:APP) positiveCorrelation a(NIFT:"Clinical dementia rating") |
| pubmed:20065247 | p(HGNC:APP) positiveCorrelation a(NIFT:"Hippocampal atrophy") |
| pubmed:26996954 | p(HGNC:APP) association p(HGNC:SORL1) |
| pubmed:31248781 | p(HGNC:APP) regulates bp(MESH:Neuroprotection) |
| pubmed:12428809 | p(HGNC:APP) association bp(GO:"axonal transport") |
| pubmed:12428809 | tloc(p(HGNC:APP), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association bp(GO:"regulation of neuronal synaptic plasticity") |
| pubmed:12428809 | tloc(p(HGNC:APP), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association bp(GO:"negative regulation of neuron apoptotic process") |
| pubmed:26968346 | deg(p(HGNC:APP)) increases p(HGNC:TFEB, loc(GO:nucleus)) |
| pubmed:26968346 | deg(p(HGNC:APP)) increases act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:22908190 | p(HGNC:APP) positiveCorrelation p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") |
| pubmed:22908190 | p(HGNC:APP) positiveCorrelation bp(GO:endocytosis) |
| pubmed:22908190 | p(HGNC:APP) increases a(GO:endosome) |
| pubmed:22908190 | p(HGNC:APP) association a(GO:autophagosome) |
| pubmed:26631930 | tloc(p(HGNC:APP), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) increases complex(p(HGNC:APP), p(HGNC:SLC40A1)) |
| pubmed:28669544 | p(HGNC:APP) increases a(MESH:Microglia) |
| pubmed:28669544 | deg(p(HGNC:APP)) directlyDecreases p(HGNC:DLG4) |
| pubmed:28669544 | deg(p(HGNC:APP)) causesNoChange p(HGNC:MAP2) |
| pubmed:28669544 | deg(p(HGNC:APP)) decreases p(HGNCGENEFAMILY:Synapsins) |
| pubmed:28669544 | deg(p(HGNC:APP)) decreases p(HGNCGENEFAMILY:Synaptophysins) |
| pubmed:28669544 | deg(p(HGNC:APP)) decreases bp(GO:"synaptic transmission, glutamatergic") |
| pubmed:30663117 | complex(g(HGNC:MIR153-1), r(HGNC:BACE1)) decreases p(HGNC:APP) |
| pubmed:30663117 | g(HGNC:MIR153-1) decreases p(HGNC:APP) |
| pubmed:30663117 | g(HGNC:MIR153-1) decreases a(CHEBI:amyloid-beta) |
| pubmed:30663117 | g(HGNC:MIR153-1) association path(MESH:"Alzheimer Disease") |
| pubmed:30663117 | g(HGNC:MIR153-1) regulates p(HGNC:SNCA) |
| pubmed:30663117 | g(HGNC:MIR153-1) regulates p(HGNC:SNCA) |
| pubmed:30663117 | g(HGNC:MIR153-1) decreases path(MESH:"Parkinson Disease") |
| pubmed:30663117 | p(HGNC:RANBP9) increases p(HGNC:APP) |
| pubmed:30663117 | g(HGNC:MIR101-1) decreases p(HGNC:APP) |
| pubmed:30663117 | g(HGNC:MIR101-1) decreases act(p(HGNC:APP)) |
| pubmed:30663117 | g(HGNC:MIR101-1) decreases act(p(HGNC:RANBP9)) |
| pubmed:30663117 | g(HGNC:MIR101-1) association path(MESH:"Alzheimer Disease") |
| pubmed:30663117 | g(HGNC:MIR101-1) decreases path(MESH:"Alzheimer Disease") |
| pubmed:30663117 | act(p(HGNC:CAMKK2), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30663117 | act(p(HGNC:CAMKK2), ma(go:0016301 ! "kinase activity")) increases act(a(CHEBI:amyloid-beta)) |
| pubmed:30116051 | p(HGNC:CAMKK2) increases act(p(HGNC:PSMC5)) |
| pubmed:30663117 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases a(GO:"neurofibrillary tangle") |
| pubmed:21214928 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases a(GO:"neurofibrillary tangle") |
| pubmed:21156028 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases a(GO:"neurofibrillary tangle") |
| pubmed:28420982 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases a(GO:"neurofibrillary tangle") |
| pubmed:24883238 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association p(HGNC:STK11) |
| pubmed:28760828 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"), loc(CONSO:"KXGS motif")) regulates act(p(HGNC:MAPT)) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"), loc(CONSO:"microtubule-binding region")) increases act(p(HGNC:MAPT), ma(GO:"acetyltransferase activity")) |
| pubmed:24760868 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association act(p(HGNC:MAPT)) |
| pubmed:26195256 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases deg(p(HGNC:MAPT)) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases composite(a(MESH:Microtubules), p(HGNC:MAPT)) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases p(CONSO:"Tau aggregates") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases bp(GO:"microtubule severing") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"), loc(CONSO:"KXGS motif")) negativeCorrelation p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:14612456 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) regulates act(p(HGNC:STUB1)) |
| pubmed:22122372 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association bp(GO:"neurofibrillary tangle assembly") |
| pubmed:25468261 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation a(CONSO:"CDR - Sum of Boxes") |
| pubmed:22701578 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation a(NIFT:"Rey auditory verbal learning test") |
| pubmed:25116835 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation p(HGNC:DYRK1A) |
| pubmed:20869593 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases path(MESH:"Alzheimer Disease") |
| pubmed:8282104 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29191965 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29191965 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29311797 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association path(MESH:"Alzheimer Disease") |
| pubmed:26458742 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:20869593 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association path(MESH:"Parkinson Disease") |
| pubmed:20869593 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association path(MESH:"Frontotemporal Dementia") |
| pubmed:18583940 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases bp(GO:"microtubule cytoskeleton organization") |
| pubmed:18583940 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases path(MESH:"Neurodegenerative Diseases") |
| pubmed:15601849 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation bp(GO:"activation of MAPKK activity") |
| pubmed:19419557 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association bp(GO:"calcium-mediated signaling") |
| pubmed:25024322 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(HGNC:CHI3L1) |
| pubmed:25865441 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(HGNC:CHI3L1) |
| pubmed:25865441 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(HGNC:CHI3L1) |
| pubmed:30515821 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases path(NCIT:C27990) |
| pubmed:19293145 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association p(HGNC:FYN) |
| pubmed:30697142 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation bp(GO:cognition) |
| pubmed:29758300 | deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases bp(GO:cognition) |
| pubmed:23516100 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association act(p(HGNC:CTSD)) |
| pubmed:31413141 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(HGNC:TREM2, frag("?")) |
| pubmed:24653673 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation", Tyr, 307)) |
| pubmed:24653673 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:MAPT)) |
| pubmed:24653673 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation a(CHEBI:homocysteine) |
| pubmed:24653673 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) |
| pubmed:30606258 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) |
| pubmed:29758300 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases act(complex(GO:"proteasome complex")) |
| pubmed:29758300 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association complex(GO:"proteasome complex") |
| pubmed:29758300 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association bp(GO:autophagy) |
| pubmed:29758300 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(HGNC:MTOR) |
| pubmed:29758300 | deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) decreases bp(GO:"neuron death") |
| pubmed:29758300 | deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) decreases path(CONSO:neuroinflammation) |
| pubmed:29758300 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(HGNC:TREM2) |
| pubmed:29758300 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(HGNC:MAPT, var("p.Ala152Thr")) |
| pubmed:24027553 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association path(MESH:"Neurofibrillary Tangles") |
| pubmed:24027553 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases act(a(CHEBI:Thrombin)) |
| pubmed:17403556 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation path(CONSO:Neurodegeneration) |
| pubmed:22611162 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(HGNC:MAPT, var("p.Lys280del")) |
| pubmed:21882945 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:21882945 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:30985105 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:14963027 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:21882945 | deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) association p(HGNC:BAG2) |
| pubmed:22419736 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation act(p(FPLX:AMPK)) |
| pubmed:22419736 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation p(FPLX:AMPK) |
| pubmed:22419736 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association path(MESH:"Retinal Degeneration") |
| pubmed:29191965 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases a(CONSO:"Tau aggregates") |
| pubmed:22817713 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases a(CONSO:"Tau aggregates") |
| pubmed:28420982 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases a(CONSO:"Tau oligomers") |
| pubmed:28420982 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases a(CONSO:"Tau oligomers") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases complex(a(MESH:Actins), p(HGNC:MAPT)) |
| pubmed:27260836 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association p(HGNC:PICALM) |
| pubmed:18467332 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases complex(p(HGNC:MAPT), p(HGNC:SRC)) |
| pubmed:18467332 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases complex(p(HGNC:MAPT), p(HGNC:PLCG1)) |
| pubmed:18467332 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases complex(p(HGNC:GRB2), p(HGNC:MAPT)) |
| pubmed:18467332 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases complex(p(HGNC:MAPT), p(HGNC:PIK3R1)) |
| pubmed:10464280 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation rxn(reactants(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) |
| pubmed:19363271 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(FPLX:HSP90) |
| pubmed:14612456 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) isA complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:STUB1), p(HGNC:UBE2D2)) |
| pubmed:23943618 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation complex(p(FPLX:PPP2), p(HGNC:MAPT)) |
| pubmed:16630055 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:19401603 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation complex(a(MESH:Microtubules), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:20869593 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:24760868 | act(p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26195256 | p(HGNC:MAPT, loc(MESH:"Neurofibrillary Tangles")) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation), loc(MESH:"Cerebrospinal Fluid")) |
| pubmed:29661268 | act(p(HGNC:MAPT), ma(GO:"acetyltransferase activity")) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:28760828 | p(HGNC:MAPT) causesNoChange p(CONSO:"Tau fibrils") |
| pubmed:28760828 | p(HGNC:MAPT) increases bp(GO:"microtubule polymerization") |
| pubmed:29238289 | p(HGNC:MAPT) association bp(GO:"microtubule polymerization") |
| pubmed:2123288 | act(p(HGNC:MAPT)) increases bp(GO:"microtubule polymerization") |
| pubmed:16566606 | p(HGNC:MAPT) increases bp(GO:"microtubule polymerization") |
| pubmed:26631930 | p(HGNC:MAPT) directlyIncreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:21339331 | p(HGNC:MAPT) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:21339331 | p(HGNC:MAPT) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:2446784 | p(HGNC:MAPT) association complex(a(MESH:Microtubules), p(HGNC:MAPT)) |
| pubmed:29661268 | p(HGNC:MAPT) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys)) |
| pubmed:29661268 | p(HGNC:MAPT) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Cys, 291)) |
| pubmed:29661268 | p(HGNC:MAPT) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Cys, 322)) |
| pubmed:29661268 | p(HGNC:MAPT) negativeCorrelation act(p(HGNC:SIRT1)) |
| pubmed:29661268 | p(HGNC:MAPT) increases act(p(HGNC:STUB1)) |
| pubmed:25116835 | p(HGNC:MAPT) negativeCorrelation p(HGNC:DYRK1A) |
| pubmed:22110360 | p(HGNC:MAPT) association p(HGNC:DYRK1A) |
| pubmed:21339331 | p(HGNC:MAPT) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) |
| pubmed:27041503 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25514383 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | p(HGNC:MAPT) association path(MESH:"Alzheimer Disease") |
| pubmed:14556719 | p(HGNC:MAPT) association path(MESH:"Alzheimer Disease") |
| pubmed:24027553 | p(HGNC:MAPT) association path(MESH:"Alzheimer Disease") |
| pubmed:24027553 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27574109 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27574109 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:30126037 | p(HGNC:MAPT) association path(MESH:"Alzheimer Disease") |
| pubmed:28420982 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:28420982 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26631930 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29238289 | p(HGNC:MAPT) biomarkerFor path(MESH:"Alzheimer Disease") |
| pubmed:25024322 | p(HGNC:MAPT) positiveCorrelation p(HGNC:CHI3L1) |
| pubmed:25865441 | p(HGNC:MAPT) positiveCorrelation p(HGNC:CHI3L1) |
| pubmed:25865441 | p(HGNC:MAPT) positiveCorrelation p(HGNC:CHI3L1) |
| pubmed:26836182 | p(HGNC:MAPT) positiveCorrelation p(HGNC:CHI3L1) |
| pubmed:26836182 | p(HGNC:MAPT) positiveCorrelation p(HGNC:CHI3L1) |
| pubmed:26235064 | p(HGNC:MAPT) association bp(GO:"neuron death") |
| pubmed:28420982 | p(HGNC:MAPT) increases bp(GO:"neuron death") |
| pubmed:29238289 | p(HGNC:MAPT) causesNoChange bp(GO:"neuron death") |
| pubmed:26235064 | p(HGNC:MAPT) association bp(GO:cognition) |
| pubmed:3122646 | p(HGNC:MAPT) association a(NIFT:"White matter") |
| pubmed:19293145 | p(HGNC:MAPT) association a(MESH:"Neurofibrillary Tangles") |
| pubmed:14556719 | p(HGNC:MAPT) association a(MESH:"Neurofibrillary Tangles") |
| pubmed:14556719 | deg(p(HGNC:MAPT)) increases a(MESH:"Neurofibrillary Tangles") |
| pubmed:27574109 | p(HGNC:MAPT) association a(MESH:"Neurofibrillary Tangles") |
| pubmed:18680553 | p(HGNC:MAPT) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) |
| pubmed:18680553 | p(HGNC:MAPT) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) |
| pubmed:26813123 | act(p(HGNC:MAPT)) association act(p(HGNC:CHRM1)) |
| pubmed:24590577 | p(HGNC:MAPT) regulates bp(GO:"microtubule anchoring") |
| pubmed:24590577 | p(HGNC:MAPT) regulates bp(GO:"axonal transport") |
| pubmed:12428809 | p(HGNC:MAPT) association bp(GO:"axonal transport") |
| pubmed:12428809 | p(HGNC:MAPT) increases bp(GO:"axonal transport") |
| pubmed:21734277 | tloc(p(HGNC:MAPT)) causesNoChange bp(GO:"axonal transport") |
| pubmed:28420982 | p(HGNC:MAPT) regulates bp(GO:"axonal transport") |
| pubmed:26631930 | p(HGNC:MAPT) regulates bp(GO:"axonal transport") |
| pubmed:26837465 | p(HGNC:MAPT) decreases act(p(HGNC:ESR1), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:22908190 | deg(p(HGNC:MAPT)) increases p(HGNC:MAPT, frag("?")) |
| pubmed:23516100 | p(HGNC:MAPT) increases p(CONSO:"Tau aggregates") |
| pubmed:29238289 | p(HGNC:MAPT) decreases tloc(p(CONSO:"Tau aggregates"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:10391244 | act(p(HGNC:MAPT), ma(GO:"microtubule binding")) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:21339331 | p(HGNC:MAPT) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:31413141 | p(HGNC:MAPT) positiveCorrelation p(HGNC:TREM2, frag("?")) |
| pubmed:19277525 | p(HGNC:MAPT) increases complex(p(HGNC:MAPT), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pubmed:21882945 | p(HGNC:MAPT) increases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:29191965 | p(HGNC:MAPT) increases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:26631930 | p(HGNC:MAPT) directlyIncreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:12428809 | p(HGNC:MAPT) increases bp(GO:"microtubule cytoskeleton organization") |
| pubmed:12428809 | p(HGNC:MAPT) decreases bp(GO:"microtubule depolymerization") |
| pubmed:12428809 | p(HGNC:MAPT) increases bp(GO:"axon development") |
| pubmed:28148553 | p(HGNC:MAPT) association bp(MESH:"Unfolded Protein Response") |
| pubmed:30108137 | tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association path(CONSO:"Pathological Tau Spreading") |
| pubmed:29758300 | p(HGNC:MAPT) increases complex(a(GO:cytoskeleton), a(GO:microtubule)) |
| pubmed:29758300 | p(HGNC:MAPT) increases bp(GO:"anterograde axonal protein transport") |
| pubmed:27373205 | p(HGNC:MAPT) causesNoChange bp(GO:"anterograde axonal protein transport") |
| pubmed:29758300 | p(HGNC:MAPT) increases bp(GO:"retrograde axonal protein transport") |
| pubmed:27373205 | p(HGNC:MAPT) causesNoChange bp(GO:"retrograde axonal protein transport") |
| pubmed:29758300 | p(HGNC:MAPT) association path(MESH:Tauopathies) |
| pubmed:29758300 | p(HGNC:MAPT) association path(MESH:"Frontotemporal Dementia") |
| pubmed:28420982 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pubmed:29758300 | p(HGNC:MAPT) association path(MESH:"Niemann-Pick Diseases") |
| pubmed:29758300 | p(HGNC:MAPT) association path(MESH:"Supranuclear Palsy, Progressive") |
| pubmed:30126037 | p(HGNC:MAPT) association path(MESH:"Supranuclear Palsy, Progressive") |
| pubmed:29758300 | p(HGNC:MAPT) association p(HGNC:NBR1) |
| pubmed:29758300 | p(HGNC:MAPT) positiveCorrelation p(HGNC:TREM2) |
| pubmed:14556719 | p(HGNC:MAPT) association a(GO:microtubule) |
| pubmed:25374103 | p(HGNC:MAPT) regulates act(a(GO:microtubule)) |
| pubmed:28420982 | p(HGNC:MAPT) increases a(GO:microtubule) |
| pubmed:26631930 | tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) negativeCorrelation a(GO:microtubule) |
| pubmed:29626319 | p(HGNC:MAPT) increases a(GO:microtubule) |
| pubmed:22908190 | p(HGNC:MAPT) association a(CONSO:"paired helical filaments") |
| pubmed:22908190 | p(HGNC:MAPT) association a(CONSO:"paired helical filaments") |
| pubmed:22908190 | p(HGNC:MAPT) association a(GO:"Lewy body") |
| pubmed:22908190 | p(HGNC:MAPT) association a(GO:"Pick body") |
| pubmed:27574109 | p(HGNC:MAPT) association a(GO:"Pick body") |
| pubmed:22908190 | p(HGNC:MAPT) causesNoChange act(complex(GO:"proteasome complex")) |
| pubmed:22908190 | p(HGNC:MAPT) negativeCorrelation act(complex(GO:"proteasome complex")) |
| pubmed:26751493 | p(HGNC:MAPT) negativeCorrelation act(complex(GO:"proteasome complex")) |
| pubmed:30145931 | p(HGNC:MAPT) increases p(HGNC:SQSTM1) |
| pubmed:30145931 | p(HGNC:MAPT, loc(MESH:Dendrites)) decreases a(MESH:"Dendritic Spines") |
| pubmed:30116051 | p(HGNC:MAPT) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:23528736 | deg(p(HGNC:MAPT)) association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:29215007 | p(HGNC:MAPT) increases bp(GO:"actin filament bundle assembly") |
| pubmed:29215007 | p(HGNC:MAPT) increases bp(GO:"actin filament bundle assembly") |
| pubmed:24760868 | p(HGNC:MAPT, loc(GO:synapse)) increases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pubmed:24027553 | p(HGNC:MAPT) negativeCorrelation act(a(MESH:Neurons)) |
| pubmed:26631930 | p(HGNC:MAPT) regulates act(a(MESH:Neurons)) |
| pubmed:26631930 | p(HGNC:MAPT) increases a(MESH:Neurons) |
| pubmed:26631930 | p(HGNC:MAPT) increases act(a(MESH:Neurons)) |
| pubmed:29238289 | p(HGNC:MAPT, loc(GO:"extracellular region")) increases act(a(MESH:Neurons)) |
| pubmed:29238289 | tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases act(a(MESH:Neurons)) |
| pubmed:27574109 | p(HGNC:MAPT) association a(CONSO:pretangles) |
| pubmed:27574109 | p(HGNC:MAPT) association a(CONSO:"Braak_Stage I") |
| pubmed:27574109 | p(HGNC:MAPT) association a(CONSO:"Braak_Stage II") |
| pubmed:27574109 | p(HGNC:MAPT) association path(CONSO:"Corticobasal Degeneration") |
| pubmed:27574109 | p(HGNC:MAPT) positiveCorrelation path(CONSO:"Corticobasal Degeneration") |
| pubmed:27574109 | p(HGNC:MAPT) positiveCorrelation path(CONSO:"Corticobasal Degeneration") |
| pubmed:27574109 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pubmed:27574109 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pubmed:29590627 | p(HGNC:MAPT) increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:26195256 | p(HGNC:MAPT, loc(MESH:"Cerebrospinal Fluid")) positiveCorrelation p(HGNC:MAPT, loc(MESH:"Neurofibrillary Tangles")) |
| pubmed:26195256 | p(HGNC:MAPT, loc(MESH:"Neurofibrillary Tangles")) positiveCorrelation p(HGNC:MAPT, loc(MESH:"Cerebrospinal Fluid")) |
| pubmed:26631930 | tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) positiveCorrelation p(HGNC:MAPT) |
| pubmed:26631930 | p(HGNC:MAPT) positiveCorrelation tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) |
| pubmed:24760868 | p(HGNC:MAPT) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pubmed:24760868 | tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pubmed:24760868 | p(HGNC:MAPT) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pubmed:24760868 | tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) association bp(MESH:"Neuronal Plasticity") |
| pubmed:24760868 | p(HGNC:MAPT) regulates bp(MESH:"Neuronal Plasticity") |
| pubmed:24760868 | p(HGNC:MAPT) increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pubmed:17187063 | p(HGNC:MAPT) increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pubmed:24760868 | p(HGNC:MAPT) increases complex(complex(GO:"actin filament bundle"), p(HGNC:MAPT)) |
| pubmed:24760868 | p(HGNC:MAPT) association complex(GO:"filamentous actin") |
| pubmed:17187063 | p(HGNC:MAPT) directlyIncreases complex(GO:"filamentous actin") |
| pubmed:28528849 | p(HGNC:MAPT) causesNoChange a(GO:synapse) |
| pubmed:26631930 | tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) decreases act(a(GO:synapse)) |
| pubmed:26631930 | tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) decreases act(a(GO:synapse)) |
| pubmed:26631930 | p(HGNC:MAPT) negativeCorrelation act(a(GO:synapse)) |
| pubmed:25887395 | p(HGNC:MAPT) causesNoChange tloc(a(CONSO:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:29980653 | tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) increases a(CONSO:"Tau fibrils") |
| pubmed:24869773 | p(HGNC:MAPT) association a(CONSO:"Tau fibrils") |
| pubmed:25887395 | p(HGNC:MAPT) causesNoChange a(CONSO:"Tau aggregates") |
| pubmed:25374103 | tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) increases a(CONSO:"Tau aggregates") |
| pubmed:28420982 | tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association a(CONSO:"Tau aggregates") |
| pubmed:27373205 | p(HGNC:MAPT) increases a(CONSO:"Tau aggregates") |
| pubmed:21882945 | deg(p(HGNC:MAPT)) negativeCorrelation bp(GO:aging) |
| pubmed:21882945 | p(HGNC:MAPT) increases path(CONSO:neurotoxicity) |
| pubmed:21882945 | deg(p(HGNC:MAPT)) negativeCorrelation p(HGNC:AKT1) |
| pubmed:20071522 | p(HGNC:MAPT) isA complex(p(HGNC:FKBP5), p(HGNC:MAPT)) |
| pubmed:30126037 | p(HGNC:MAPT) association path(MESH:"Brain Injuries, Traumatic") |
| pubmed:22419736 | p(HGNC:MAPT) increases path(MESH:"Retinal Degeneration") |
| pubmed:29191965 | p(HGNC:MAPT) increases complex(p(HGNC:MAPT), p(HGNC:TUBA1A)) |
| pubmed:29191965 | p(HGNC:MAPT) increases complex(p(HGNC:MAPT), p(HGNC:TUBB)) |
| pubmed:29191965 | p(HGNC:MAPT) association a(GO:"cell body") |
| pubmed:25374103 | p(HGNC:MAPT) decreases bp(GO:"anterograde axonal transport") |
| pubmed:26631930 | p(HGNC:MAPT) decreases bp(GO:"anterograde axonal transport") |
| pubmed:28420982 | p(HGNC:MAPT) regulates bp(GO:"generation of neurons") |
| pubmed:28420982 | p(HGNC:MAPT) increases bp(HP:Neurodegeneration) |
| pubmed:28420982 | p(HGNC:MAPT) increases bp(GO:"cell death") |
| pubmed:28420982 | p(HGNC:MAPT) association bp(GO:behavior) |
| pubmed:28420982 | p(HGNC:MAPT) decreases bp(GO:"synaptic signaling") |
| pubmed:28420982 | p(HGNC:MAPT) association bp(GO:"intracellular signal transduction") |
| pubmed:28420982 | tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"cell body")) association bp(MESH:Aging) |
| pubmed:28420982 | tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:dendrite)) association bp(MESH:Aging) |
| pubmed:28420982 | tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association a(MESH:Exosomes) |
| pubmed:29238289 | p(HGNC:MAPT) association act(a(MESH:Exosomes)) |
| pubmed:28420982 | tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association a(GO:microvesicle) |
| pubmed:28420982 | p(HGNC:MAPT) increases a(CHEBI:"calcium(2+)") |
| pubmed:16566606 | act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 394)) |
| pubmed:26751493 | p(HGNC:MAPT) decreases act(p(HGNC:HDAC6)) |
| pubmed:26751493 | p(HGNC:MAPT) regulates bp(MESH:"Transcription, Genetic") |
| pubmed:26751493 | p(HGNC:MAPT) decreases bp(GO:autophagy) |
| pubmed:26751493 | p(HGNC:MAPT) positiveCorrelation bp(GO:"clathrin-dependent endocytosis") |
| pubmed:27373205 | p(HGNC:MAPT) increases a(CONSO:"Tau oligomers") |
| pubmed:16566606 | act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) |
| pubmed:16566606 | act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) |
| pubmed:26631930 | tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) association path(CONSO:Neurodegeneration) |
| pubmed:26631930 | act(p(HGNC:MAPT)) association path(CONSO:Neurodegeneration) |
| pubmed:26631930 | p(HGNC:MAPT) association act(a(MESH:Dyneins)) |
| pubmed:26631930 | p(HGNC:MAPT) association act(a(MESH:Kinesin)) |
| pubmed:26631930 | p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Dyneins)) |
| pubmed:22817713 | p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Dyneins)) |
| pubmed:26631930 | p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Kinesin)) |
| pubmed:22817713 | p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Kinesin)) |
| pubmed:26631930 | p(HGNC:MAPT) decreases bp(GO:"retrograde axonal transport") |
| pubmed:26631930 | p(HGNC:MAPT) increases act(p(HGNC:GSK3B)) |
| pubmed:26631930 | p(HGNC:MAPT) increases act(p(HGNC:PPP1R8)) |
| pubmed:26631930 | p(HGNC:MAPT) directlyIncreases complex(p(HGNC:DCTN1), p(HGNC:MAPT)) |
| pubmed:8391280 | p(HGNC:MAPT) isA complex(p(HGNC:DCTN1), p(HGNC:MAPT)) |
| pubmed:26631930 | p(HGNC:MAPT) increases a(MESH:Neurites) |
| pubmed:26631930 | p(HGNC:MAPT) association bp(GO:"regulation of synaptic plasticity") |
| pubmed:26631930 | p(HGNC:MAPT) increases path(CONSO:Excitotoxicity) |
| pubmed:26631930 | p(HGNC:MAPT) association bp(GO:neurogenesis) |
| pubmed:26631930 | p(HGNC:MAPT) association bp(GO:neurogenesis) |
| pubmed:26631930 | p(HGNC:MAPT) decreases a(CHEBI:"iron(0)") |
| pubmed:26631930 | p(HGNC:MAPT) decreases a(CHEBI:"iron(0)") |
| pubmed:26631930 | p(HGNC:MAPT) increases bp(GO:locomotion) |
| pubmed:26631930 | p(HGNC:MAPT) increases tloc(p(HGNC:APP), fromLoc(GO:cytoplasm), toLoc(GO:"cell surface")) |
| pubmed:26631930 | p(HGNC:MAPT) increases bp(GO:"long-term synaptic depression") |
| pubmed:26631930 | p(HGNC:MAPT) association bp(GO:"long-term synaptic depression") |
| pubmed:26631930 | p(HGNC:MAPT) directlyIncreases complex(a(MESH:Actins), p(HGNC:MAPT)) |
| pubmed:26631930 | p(HGNC:MAPT) increases act(a(MESH:Brain)) |
| pubmed:26631930 | p(HGNC:MAPT) decreases path(MESH:Dementia) |
| pubmed:26631930 | p(HGNC:MAPT) association bp(GO:"iron ion transport") |
| pubmed:26631930 | p(HGNC:MAPT) association bp(GO:"DNA protection") |
| pubmed:26631930 | tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) regulates act(a(CHEBI:amyloid-beta)) |
| pubmed:26631930 | tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) increases tloc(p(HGNC:TTLL6), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) |
| pubmed:26631930 | p(HGNC:MAPT) increases complex(p(HGNC:DLG4), p(HGNC:FYN)) |
| pubmed:22817713 | p(HGNC:MAPT) association bp(GO:"regulation of microtubule cytoskeleton organization") |
| pubmed:29626319 | p(HGNC:MAPT) decreases p(HGNC:PSMD7) |
| pubmed:29238289 | p(HGNC:MAPT) association a(MESH:Microtubules) |
| pubmed:29238289 | p(HGNC:MAPT, loc(GO:"extracellular region")) increases path(MESH:"Cytotoxicity, Immunologic") |
| pubmed:29238289 | tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association p(HGNC:RAB7A) |
| pubmed:29238289 | tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association p(HGNC:RAB1A) |
| pubmed:29238289 | tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association a(MESH:"Transport Vesicles") |
| pubmed:1918161 | p(HGNC:MAPT) directlyIncreases complex(GO:microtubule, loc(GO:"axon cytoplasm")) |
| pubmed:10464280 | p(HGNC:MAPT) association complex(GO:microtubule) |
| pubmed:1918161 | p(HGNC:MAPT) positiveCorrelation complex(GO:axon) |
| pubmed:1918161 | p(HGNC:MAPT) positiveCorrelation complex(GO:"neuron projection") |
| pubmed:17187063 | p(HGNC:MAPT) directlyIncreases complex(GO:"actin filament bundle") |
| pubmed:6543144 | p(HGNC:MAPT) association complex(GO:neurofilament) |
| pubmed:11812770 | p(HGNC:MAPT) positiveCorrelation complex(p(HGNC:GSK3B), p(HGNC:MAPT)) |
| pubmed:18680553 | p(HGNC:MAPT) association bp(GO:myelination) |
| pubmed:18467332 | p(HGNC:MAPT) association p(HGNC:SRC, frag("84_145")) |
| pubmed:18467332 | p(HGNC:MAPT) isA complex(p(HGNC:MAPT), p(HGNC:SRC)) |
| pubmed:18467332 | p(HGNC:MAPT) association p(HGNC:PLCG1, frag("790_851")) |
| pubmed:18467332 | p(HGNC:MAPT) isA complex(p(HGNC:MAPT), p(HGNC:PLCG1)) |
| pubmed:18467332 | p(HGNC:MAPT) association p(HGNC:GRB2, frag("1_57")) |
| pubmed:18467332 | p(HGNC:MAPT) association complex(p(HGNC:GRB2), p(HGNC:MAPT)) |
| pubmed:18467332 | p(HGNC:MAPT) association p(HGNC:PIK3R1, frag("3_79")) |
| pubmed:18467332 | p(HGNC:MAPT) isA complex(p(HGNC:MAPT), p(HGNC:PIK3R1)) |
| pubmed:10464280 | p(HGNC:MAPT) increases complex(complex(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:17954934 | p(HGNC:MAPT) isA complex(p(HGNC:BAG1), p(HGNC:HSPA8), p(HGNC:MAPT)) |
| pubmed:17954934 | p(HGNC:MAPT) positiveCorrelation p(HGNC:BAG1) |
| pubmed:8391280 | p(HGNC:MAPT) increases act(p(INTERPRO:"Dynein associated protein")) |
| pubmed:21367866 | deg(p(HGNC:MAPT)) negativeCorrelation complex(p(FPLX:HSP90), p(HGNC:CDC37)) |
| pubmed:2123288 | p(HGNC:MAPT) isA complex(p(FPLX:CALM), p(HGNC:MAPT)) |
| pubmed:2123288 | act(p(HGNC:MAPT)) negativeCorrelation complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) |
| pubmed:2833519 | p(HGNC:MAPT) association p(HGNC:S100B) |
| pubmed:2833519 | p(HGNC:MAPT) isA complex(p(HGNC:MAPT), p(HGNC:S100B)) |
| pubmed:12551948 | p(HGNC:MAPT) isA complex(p(HGNC:GSK3B), p(HGNC:MAPT), p(HGNC:YWHAZ)) |
| pubmed:12551948 | p(HGNC:MAPT) association p(HGNC:YWHAZ) |
| pubmed:21339331 | p(HGNC:MAPT) association p(HGNC:ANXA2) |
| pubmed:21339331 | p(HGNC:MAPT) isA complex(p(HGNC:ANXA2), p(HGNC:MAPT)) |
| pubmed:21131359 | p(HGNC:MAPT) isA complex(a(CHEBI:"double-stranded DNA"), p(HGNC:MAPT)) |
| pubmed:21131359 | p(HGNC:MAPT) association a(CHEBI:"double-stranded DNA") |
| pubmed:21131359 | p(HGNC:MAPT) negativeCorrelation bp(MESH:"Hot Temperature") |
| pubmed:16566606 | act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) |
| pubmed:16566606 | p(HGNC:MAPT) increases bp(GO:"tubulin complex assembly") |
| pubmed:24869773 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 24)) |
| pubmed:24869773 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 44)) |
| pubmed:24869773 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 67)) |
| pubmed:24869773 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 190)) |
| pubmed:19251756 | p(HGNC:MAPT) association p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation")) |
| pubmed:19251756 | p(HGNC:MAPT) partOf complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation"))) |
| pubmed:10537045 | p(HGNC:MAPT) positiveCorrelation p(HGNC:TGM2) |
| pubmed:10537045 | p(HGNC:MAPT) partOf complex(p(HGNC:MAPT), p(HGNC:TGM2)) |
| pubmed:24853415 | p(HGNC:MAPT) positiveCorrelation p(HGNC:DAPK1) |
| pubmed:24853415 | p(HGNC:MAPT) positiveCorrelation p(HGNC:PIN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 71)) |
| pubmed:26091809 | p(HGNC:MAPT, loc(GO:"inclusion body")) decreases p(HGNC:TARDBP) |
| pubmed:30988501 | p(HGNC:MAPT) biomarkerFor path(DOID:"Alzheimer's disease") |
| pubmed:25652642 | a(GO:"neurofibrillary tangle") positiveCorrelation act(complex(GO:"NF-kappaB complex")) |
| pubmed:29196815 | a(GO:"neurofibrillary tangle") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:28420982 | a(GO:"neurofibrillary tangle") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22817713 | a(GO:"neurofibrillary tangle") association path(MESH:"Alzheimer Disease") |
| pubmed:11089576 | a(GO:"neurofibrillary tangle") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21156028 | a(GO:"neurofibrillary tangle") increases bp(GO:"neuron death") |
| pubmed:24653673 | a(GO:"neurofibrillary tangle") association p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation", Tyr, 307)) |
| pubmed:29758300 | a(GO:"neurofibrillary tangle") association p(HGNC:BECN1, frag("?")) |
| pubmed:22908190 | a(GO:"neurofibrillary tangle") association a(CONSO:"paired helical filaments") |
| pubmed:22908190 | a(GO:"neurofibrillary tangle") association a(MESH:Ubiquitin) |
| pubmed:22908190 | a(GO:"neurofibrillary tangle") negativeCorrelation act(complex(GO:"proteasome complex")) |
| pubmed:22908190 | a(GO:"neurofibrillary tangle") negativeCorrelation p(HGNC:UCHL1, pmod(GO:"protein oxidation")) |
| pubmed:22908190 | a(GO:"neurofibrillary tangle") association bp(GO:"protein K63-linked ubiquitination") |
| pubmed:22908190 | a(GO:"neurofibrillary tangle") association p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:18930136 | a(GO:"neurofibrillary tangle") association p(HGNC:SQSTM1) |
| pubmed:27671637 | a(GO:"neurofibrillary tangle") positiveCorrelation p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") decreases bp(GO:cognition) |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") increases bp(GO:"cell death") |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") decreases bp(GO:"cell death") |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") positiveCorrelation p(MGI:Cdkn2a) |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") increases act(p(MGI:Cdkn2a)) |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") increases p(MGI:Cdkn2a) |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") increases p(MGI:Cdkn2a) |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") association bp(GO:"cellular senescence") |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") increases bp(MESH:"Cell Survival") |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") increases bp(GO:"inflammatory response") |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") increases bp(GO:"cell cycle") |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") decreases bp(GO:"apoptotic process") |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") decreases path(MESH:Necrosis) |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") increases p(HGNC:NFKB1) |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") increases p(HGNC:IFNG) |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") increases p(HGNC:TNF) |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") increases p(HGNC:TLR4) |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") increases p(HGNC:IL1B) |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") increases p(HGNC:CXCL1) |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") increases act(p(MGI:Ifng)) |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") increases act(p(MGI:Tnf)) |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") increases act(p(MGI:Il1b)) |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") increases act(p(MGI:Jak1)) |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") increases act(p(MGI:Stat1)) |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") increases act(p(MGI:Bcl2)) |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") association p(HGNC:CDKN2A) |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:CDKN2A) |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") increases p(HGNC:CDKN2A) |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") decreases bp(GO:"oxygen transport") |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") association path(MESH:"Hypertrophy, Right Ventricular") |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") association path(MESH:"Hypertrophy, Left Ventricular") |
| pubmed:30126037 | a(GO:"neurofibrillary tangle") association path(HP:"Brain atrophy") |
| pubmed:30985105 | deg(a(GO:"neurofibrillary tangle")) negativeCorrelation p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:26751493 | a(GO:"neurofibrillary tangle") negativeCorrelation r(HGNC:SYP) |
| pubmed:26751493 | a(GO:"neurofibrillary tangle") negativeCorrelation p(HGNC:SNAP25) |
| pubmed:26751493 | a(GO:"neurofibrillary tangle") negativeCorrelation p(PFAM:Syntaxin) |
| pubmed:23531502 | a(GO:"neurofibrillary tangle") association act(a(CHEBI:acrolein)) |
| pubmed:12578227 | a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:TGM1) |
| pubmed:12578227 | a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:TGM2) |
| pubmed:11089576 | a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:2.3.2.13)) |
| pubmed:11738469 | a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:2.3.2.13)) |
| pubmed:8985134 | a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:2.3.2.13)) |
| pubmed:11089576 | a(GO:"neurofibrillary tangle") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pubmed:9099822 | a(GO:"neurofibrillary tangle") positiveCorrelation act(p(HGNCGENEFAMILY:Transglutaminases)) |
| pubmed:23088643 | a(GO:"neurofibrillary tangle") association p(CONSO:"Tau epitope, AT8") |
| pubmed:23088643 | a(GO:"neurofibrillary tangle") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:26751493 | a(GO:"neurofibrillary tangle") negativeCorrelation p(INTERPRO:"Syntaxin, N-terminal domain") |
| pubmed:26118667 | a(GO:"neurofibrillary tangle") positiveCorrelation p(CONSO:"CDK5R1 p25") |
| pubmed:29844403 | a(GO:"neurofibrillary tangle") positiveCorrelation a(CONSO:"Tau aggregates") |
| pubmed:21734277 | a(GO:"neurofibrillary tangle") decreases bp(GO:"axonal transport") |
| pubmed:21734277 | a(GO:"neurofibrillary tangle") increases act(p(FPLX:PPP1)) |
| pubmed:21734277 | a(GO:"neurofibrillary tangle") increases act(p(HGNC:GSK3B)) |
| pubmed:23832849 | a(GO:"neurofibrillary tangle") association p(HGNC:FKBP1A) |
| pubmed:30663117 | g(HGNC:MIR9-1) decreases a(GO:"neurofibrillary tangle") |
| pubmed:30663117 | g(HGNC:MIR9-1) decreases act(p(HGNC:MAP2K2)) |
| pubmed:30663117 | g(HGNC:MIR9-1) association path(MESH:"Alzheimer Disease") |
| pubmed:30663117 | act(p(HGNC:MAP2K2)) increases a(GO:"neurofibrillary tangle") |
| pubmed:30663117 | a(MESH:"RNA, Long Noncoding") increases bp(GO:"apoptotic process") |
| pubmed:28745240 | bp(GO:"apoptotic process") negativeCorrelation p(HGNC:RELA) |
| pubmed:27288790 | bp(GO:"apoptotic process") association p(FPLX:NFkappaB) |
| pubmed:22236693 | bp(GO:"apoptotic process") negativeCorrelation p(HGNC:NTRK1) |
| pubmed:20100581 | bp(GO:"apoptotic process") association bp(GO:"microglial cell activation") |
| pubmed:20100581 | bp(GO:"apoptotic process") association a(NIFT:"Hippocampal atrophy") |
| pubmed:19293145 | bp(GO:"apoptotic process") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:18986241 | bp(GO:"apoptotic process") association bp(GO:"MAPK cascade") |
| pubmed:24653673 | bp(GO:"apoptotic process") positiveCorrelation act(p(HGNC:GSK3B)) |
| pubmed:24653673 | bp(GO:"apoptotic process") positiveCorrelation act(p(HGNC:CDK5)) |
| pubmed:24653673 | bp(GO:"apoptotic process") positiveCorrelation act(p(FPLX:ERK)) |
| pubmed:30012004 | bp(GO:"apoptotic process") positiveCorrelation path(MESH:"Huntington Disease") |
| pubmed:24563850 | bp(GO:"apoptotic process") increases bp(GO:"cell death") |
| pubmed:24027553 | bp(GO:"apoptotic process") increases act(p(HGNCGENEFAMILY:Calpains)) |
| pubmed:24027553 | bp(GO:"apoptotic process") increases p(HGNC:MAPT, frag("?", "17kD")) |
| pubmed:24027553 | bp(GO:"apoptotic process") increases act(p(HGNC:CASP6)) |
| pubmed:26304819 | bp(GO:"apoptotic process") association r(HGNC:GAPDH) |
| pubmed:23948915 | bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:23948915 | bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:23948915 | bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:30663117 | g(HGNC:EBF3) isA a(MESH:"RNA, Long Noncoding") |
| pubmed:30663117 | bp(GO:"neuron death") increases g(MGI:Ebf3) |
| pubmed:27794524 | bp(GO:"neuron death") association path(MESH:"Oxidative Stress") |
| pubmed:29661268 | bp(GO:"neuron death") negativeCorrelation p(HGNC:STUB1) |
| pubmed:30444369 | bp(GO:"neuron death") association p(HGNC:SH3GL2) |
| pubmed:29196815 | bp(GO:"neuron death") positiveCorrelation a(CONSO:CONSO00074) |
| pubmed:21214928 | bp(GO:"neuron death") association complex(p(CONSO:CONSO00042), p(HGNC:TNFRSF21)) |
| pubmed:22122372 | bp(GO:"neuron death") association path(MESH:"Alzheimer Disease") |
| pubmed:17009926 | bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:17009926 | bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25514383 | bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21722302 | bp(GO:"neuron death") prognosticBiomarkerFor path(MESH:"Alzheimer Disease") |
| pubmed:28420982 | bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26631930 | bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19625741 | bp(GO:"neuron death") positiveCorrelation p(HGNC:GRN) |
| pubmed:26235064 | bp(GO:"neuron death") association p(HGNC:MAPT) |
| pubmed:22426017 | bp(GO:"neuron death") increases a(NIFT:"Cortical Thinning") |
| pubmed:14970312 | bp(GO:"neuron death") increases a(NIFT:"Hippocampal atrophy") |
| pubmed:14970312 | bp(GO:"neuron death") increases a(NIFT:"Hippocampal atrophy") |
| pubmed:21787755 | bp(GO:"neuron death") association p(CONSO:"alpha-7-containing nAChR") |
| pubmed:23516100 | bp(GO:"neuron death") positiveCorrelation p(HGNC:ATXN3, frag("1_?")) |
| pubmed:30012004 | bp(GO:"neuron death") increases path(MESH:Atrophy) |
| pubmed:30012004 | bp(GO:"neuron death") positiveCorrelation path(MESH:"Huntington Disease") |
| pubmed:30012004 | bp(GO:"neuron death") positiveCorrelation path(MESH:"Huntington Disease") |
| pubmed:21861815 | bp(GO:"neuron death") increases path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:21722302 | bp(GO:"neuron death") association p(HGNC:PRNP) |
| pubmed:29758300 | bp(GO:"neuron death") association path(MESH:"Neurodegenerative Diseases") |
| pubmed:14556719 | bp(GO:"neuron death") positiveCorrelation path(MESH:"Parkinson Disease") |
| pubmed:22908190 | bp(GO:"neuron death") positiveCorrelation act(p(HGNC:RAB5A)) |
| pubmed:24027553 | bp(GO:"neuron death") negativeCorrelation bp(MESH:Autophagy) |
| pubmed:21882945 | bp(GO:"neuron death") positiveCorrelation path(MESH:Tauopathies) |
| pubmed:28420982 | bp(GO:"neuron death") association path(MESH:Tauopathies) |
| pubmed:30663117 | a(CONSO:"alpha-synuclein aggregates") association path(MESH:"Parkinson Disease") |
| pubmed:30663117 | a(CONSO:"alpha-synuclein aggregates") increases path(MESH:"Parkinson Disease") |
| pubmed:30663117 | a(CONSO:"alpha-synuclein aggregates") decreases a(MESH:"Dopaminergic Neurons") |
| pubmed:30663117 | a(CONSO:"alpha-synuclein aggregates") negativeCorrelation a(MESH:"HSP70 Heat-Shock Proteins") |
| pubmed:29758300 | a(CONSO:"alpha-synuclein aggregates") association path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | a(CONSO:"alpha-synuclein aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:14556719 | a(CONSO:"alpha-synuclein aggregates") association a(MESH:"Lewy Bodies") |
| pubmed:14556719 | a(CONSO:"alpha-synuclein aggregates") positiveCorrelation path(MESH:"Parkinsonian Disorders") |
| pubmed:14556719 | a(CONSO:"alpha-synuclein aggregates") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:30116051 | a(CONSO:"alpha-synuclein aggregates") decreases complex(GO:"proteasome complex") |
| pubmed:30985105 | a(CONSO:"alpha-synuclein aggregates") decreases bp(GO:"neuron death") |
| pubmed:30985105 | a(CONSO:"alpha-synuclein aggregates") negativeCorrelation a(CONSO:"alpha-synuclein oligomers") |
| pubmed:30663117 | p(HGNC:SNCA, pmod(CONSO:misfolded)) association path(MESH:"Parkinson Disease") |
| pubmed:21722302 | p(HGNC:SNCA, pmod(CONSO:misfolded)) increases a(CONSO:"alpha-synuclein aggregates") |
| pubmed:30663117 | p(HGNC:SNCA) association bp(GO:"synaptic transmission, dopaminergic") |
| pubmed:30663117 | p(HGNC:SNCA) positiveCorrelation a(GO:"Lewy body", loc(MESH:"Dopaminergic Neurons")) |
| pubmed:30962309 | p(HGNC:SNCA) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:30962309 | p(HGNC:SNCA) increases act(p(HGNC:IL1B)) |
| pubmed:30962309 | p(HGNC:SNCA) increases path(DOID:"neurodegenerative disease") |
| pubmed:30688256 | p(HGNC:SNCA) decreases bp(GO:"apoptotic process") |
| pubmed:14556719 | p(HGNC:SNCA) increases bp(GO:"apoptotic process") |
| pubmed:30688256 | p(HGNC:SNCA) increases act(a(MESH:Mitochondria)) |
| pubmed:30688256 | p(HGNC:SNCA) decreases path(MESH:"Oxidative Stress") |
| pubmed:30688256 | p(HGNC:SNCA) increases bp(GO:mitophagy) |
| pubmed:21722302 | p(HGNC:SNCA) regulates bp(MESH:"Protein Stability") |
| pubmed:26968346 | p(HGNC:SNCA) negativeCorrelation bp(GO:"regulation of glucosylceramidase activity") |
| pubmed:27299292 | p(HGNC:SNCA) increases p(HGNC:TFEB, loc(GO:cytoplasm)) |
| pubmed:29758300 | p(HGNC:SNCA) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | p(HGNC:SNCA) increases path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | p(HGNC:SNCA) increases path(MESH:"Parkinson Disease") |
| pubmed:28803412 | p(HGNC:SNCA) association path(MESH:"Parkinson Disease") |
| pubmed:29758300 | p(HGNC:SNCA) association bp(GO:"chaperone-mediated autophagy") |
| pubmed:14556719 | p(HGNC:SNCA) association p(HGNC:SNCAIP) |
| pubmed:22908190 | p(HGNC:SNCA) positiveCorrelation p(HGNC:SNCA, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:14556719 | p(HGNC:SNCA) regulates bp(GO:"dopamine secretion, neurotransmission") |
| pubmed:14556719 | p(HGNC:SNCA) regulates bp(GO:"dopamine secretion") |
| pubmed:30985105 | p(HGNC:SNCA) association bp(GO:"dopamine secretion") |
| pubmed:14556719 | p(HGNC:SNCA) positiveCorrelation bp(CONSO:"Alpha-synuclein Oligomerization") |
| pubmed:14556719 | act(p(HGNC:SNCA)) increases p(HGNC:SNCAIP, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:14556719 | act(p(HGNC:SNCA)) increases p(HGNC:TH, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:14556719 | act(p(HGNC:SNCA)) regulates bp(GO:"homeostatic process") |
| pubmed:14556719 | p(HGNC:SNCA) association a(MESH:"Inclusion Bodies") |
| pubmed:22908190 | p(HGNC:SNCA) increases complex(a(GO:"Lewy body"), p(HGNC:SNCA)) |
| pubmed:25784053 | p(HGNC:SNCA) decreases bp(GO:autophagy) |
| pubmed:25784053 | p(HGNC:SNCA) decreases p(HGNC:RAB1A) |
| pubmed:30985105 | p(HGNC:SNCA) regulates a(GO:"synaptic vesicle") |
| pubmed:30985105 | p(HGNC:SNCA) increases a(CONSO:"alpha-synuclein fibrils") |
| pubmed:29980653 | tloc(p(HGNC:SNCA), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) increases a(CONSO:"alpha-synuclein fibrils") |
| pubmed:21482353 | a(MESH:"Dopaminergic Neurons") positiveCorrelation p(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:19721446 | a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) |
| pubmed:19721446 | a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) |
| pubmed:19721446 | a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2)) |
| pubmed:19721446 | a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| pubmed:19721446 | a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2)) |
| pubmed:28901280 | a(MESH:"Dopaminergic Neurons") regulates a(MESH:Nicotine) |
| pubmed:14556719 | a(MESH:"Dopaminergic Neurons") negativeCorrelation p(HGNC:PRKN) |
| pubmed:30663117 | bp(GO:"synaptic transmission, dopaminergic") association p(HGNC:SNCA) |
| pubmed:22372633 | bp(GO:"synaptic transmission, dopaminergic") positiveCorrelation p(HGNC:HDAC6) |
| pubmed:22372633 | bp(GO:"synaptic transmission, dopaminergic") negativeCorrelation p(HGNC:SNCA, var("?")) |
| pubmed:27013968 | bp(GO:"synaptic transmission, dopaminergic") negativeCorrelation p(HGNC:HTT, pmod(HBP:"CAG repeats")) |
| pubmed:14556719 | bp(GO:"synaptic transmission, dopaminergic") negativeCorrelation path(MESH:"Parkinson Disease") |
| pubmed:30663117 | p(HGNC:SNCA, var("?")) increases path(MESH:"Parkinson Disease") |
| pubmed:18930136 | p(HGNC:SNCA, var("?")) increases path(MESH:"Parkinson Disease") |
| pubmed:30985105 | p(HGNC:SNCA, var("?")) increases path(MESH:"Parkinson Disease") |
| pubmed:29980653 | p(HGNC:SNCA, var("?")) positiveCorrelation path(MESH:"Parkinson Disease") |
| pubmed:22372633 | p(HGNC:SNCA, var("?")) increases p(HGNC:HDAC6, loc(GO:"perinuclear region of cytoplasm")) |
| pubmed:22372633 | p(HGNC:SNCA, var("?")) increases complex(a(HGNC:HDAC6), p(HGNC:SNCA), loc(GO:"perinuclear region of cytoplasm")) |
| pubmed:22372633 | p(HGNC:SNCA, var("?")) negativeCorrelation bp(GO:"synaptic transmission, dopaminergic") |
| pubmed:22372633 | p(HGNC:SNCA, var("?")) positiveCorrelation path(DOID:"retinal degeneration") |
| pubmed:30061532 | p(HGNC:SNCA, var("?")) association path(MESH:"Psychotic Disorders") |
| pubmed:21722302 | p(HGNC:SNCA, var("?")) increases path(DOID:"autosomal dominant Parkinson's disease 1") |
| pubmed:26968346 | p(HGNC:SNCA, var("?")) negativeCorrelation bp(GO:"chaperone-mediated autophagy") |
| pubmed:29758300 | p(HGNC:SNCA, var("?")) association bp(GO:"chaperone-mediated autophagy") |
| pubmed:26968346 | p(HGNC:SNCA, var("?")) increases p(CONSO:"alpha-synuclein aggregates") |
| pubmed:26968346 | p(HGNC:SNCA, var("?")) decreases p(HGNC:MEF2D) |
| pubmed:27491084 | p(HGNC:SNCA, var("?")) association path(HP:Neurodegeneration) |
| pubmed:14556719 | p(HGNC:SNCA, var("?")) association path(MESH:"Parkinsonian Disorders") |
| pubmed:14556719 | p(HGNC:SNCA, var("?")) increases bp(GO:"apoptotic process") |
| pubmed:18930136 | p(HGNC:SNCA, var("?")) decreases tloc(p(HGNC:SNCA, var("?")), fromLoc(GO:cytoplasm), toLoc(GO:"lysosomal lumen")) |
| pubmed:30116051 | p(HGNC:SNCA, var("?")) decreases bp(GO:"autophagosome assembly") |
| pubmed:30116051 | p(HGNC:SNCA, var("?")) decreases a(GO:"lysosomal membrane") |
| pubmed:30116051 | p(HGNC:SNCA, var("?")) decreases complex(GO:"proteasome complex") |
| pubmed:30663117 | a(GO:"Lewy body", loc(MESH:"Dopaminergic Neurons")) positiveCorrelation p(HGNC:SNCA) |
| pubmed:21722302 | a(GO:"Lewy body") increases p(HGNC:SNCA) |
| pubmed:21722302 | a(GO:"Lewy body") biomarkerFor path(MESH:"Parkinson Disease") |
| pubmed:21722302 | a(GO:"Lewy body") increases p(HGNC:SNCA, pmod(CONSO:misfolded)) |
| pubmed:22908190 | a(GO:"Lewy body") association a(MESH:Ubiquitin) |
| pubmed:22908190 | a(GO:"Lewy body") association a(MESH:Ubiquitin) |
| pubmed:22908190 | a(GO:"Lewy body") positiveCorrelation path(MESH:Dementia) |
| pubmed:22908190 | a(GO:"Lewy body") positiveCorrelation path(MESH:Dementia) |
| pubmed:22908190 | a(GO:"Lewy body") association p(HGNC:MAPT) |
| pubmed:18930136 | a(GO:"Lewy body") association p(HGNC:SQSTM1) |
| pubmed:30663117 | g(HGNC:MIR7-1) regulates p(HGNC:SNCA) |
| pubmed:30663117 | g(HGNC:MIR7-1) decreases p(HGNC:SNCA) |
| pubmed:30663117 | g(HGNC:MIR7-1) regulates p(HGNC:SNCA) |
| pubmed:30663117 | g(HGNC:MIR7-1) decreases path(MESH:"Parkinson Disease") |
| pubmed:30663117 | complex(g(HGNC:MIR153-1), r(HGNC:SNCA)) decreases act(p(HGNC:SNCA)) |
| pubmed:" 23273601" | r(HGNC:SNCA) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:30663117 | complex(g(HGNC:MIR7-1), r(HGNC:SNCA)) decreases act(p(HGNC:SNCA)) |
| pubmed:30663117 | complex(g(HGNC:MIR34B), r(HGNC:SNCA)) decreases p(HGNC:SNCA) |
| pubmed:30663117 | g(HGNC:MIR34B) increases p(HGNC:PARK7) |
| pubmed:30663117 | complex(g(HGNC:MIR34C), r(HGNC:SNCA)) decreases p(HGNC:SNCA) |
| pubmed:30663117 | g(HGNC:MIR34C) increases p(HGNC:PARK7) |
| pubmed:30663117 | g(HGNC:MIR132) regulates p(HGNC:SNCA) |
| pubmed:30663117 | g(HGNC:MIR132) decreases p(HGNC:SNCA) |
| pubmed:30663117 | g(HGNC:MIR132) regulates p(HGNC:SNCA) |
| pubmed:30663117 | g(HGNC:MIR132) association path(MESH:"Parkinson Disease") |
| pubmed:30663117 | g(HGNC:MIR132) decreases path(MESH:"Parkinson Disease") |
| pubmed:30663117 | g(HGNC:MIR132) association p(HGNC:NR4A2) |
| pubmed:30663117 | p(HGNC:NR4A2) association g(HGNC:MIR132) |
| pubmed:30663117 | g(NCBIGENE:406950) association path(MESH:"Parkinson Disease") |
| pubmed:30663117 | g(NCBIGENE:406950) decreases a(MESH:"HSP70 Heat-Shock Proteins") |
| pubmed:30663117 | g(NCBIGENE:406950) negativeCorrelation a(MESH:"HSP70 Heat-Shock Proteins") |
| pubmed:30663117 | g(NCBIGENE:406950) increases a(CONSO:"alpha-synuclein aggregates") |
| pubmed:30663117 | a(MESH:"HSP70 Heat-Shock Proteins") negativeCorrelation a(CONSO:"alpha-synuclein aggregates") |
| pubmed:30663117 | a(MESH:"HSP70 Heat-Shock Proteins") decreases a(CONSO:"alpha-synuclein aggregates") |
| pubmed:30663117 | a(MESH:"HSP70 Heat-Shock Proteins") negativeCorrelation g(NCBIGENE:406950) |
| pubmed:25374103 | a(MESH:"HSP70 Heat-Shock Proteins") increases deg(p(HGNC:MAPT, pmod(CONSO:misfolded))) |
| pubmed:30663117 | complex(a(MESH:"HSP70 Heat-Shock Proteins"), g(NCBIGENE:406950)) regulates act(a(MESH:"HSP70 Heat-Shock Proteins")) |
| pubmed:30663117 | g(HGNC:MIR133B) decreases path(MESH:"Parkinson Disease") |
| pubmed:30663117 | g(HGNC:MIR133B) regulates p(HGNC:SNCA) |
| pubmed:30663117 | p(HGNC:LRRK2) association path(MESH:"Parkinson Disease") |
| pubmed:30688256 | p(HGNC:LRRK2) association path(MESH:"Parkinson Disease") |
| pubmed:24113872 | p(HGNC:LRRK2) positiveCorrelation path(MESH:"Parkinson Disease") |
| pubmed:30663117 | p(HGNC:LRRK2) decreases g(HGNC:MIRLET7A1) |
| pubmed:30663117 | p(HGNC:LRRK2) decreases act(g(HGNC:MIRLET7A1)) |
| pubmed:30663117 | p(HGNC:LRRK2) decreases g(HGNC:MIR184) |
| pubmed:30663117 | p(HGNC:LRRK2) decreases act(g(HGNC:MIR184)) |
| pubmed:24275654 | p(HGNC:LRRK2) association p(HGNC:TUBB6) |
| pubmed:24275654 | p(HGNC:LRRK2) association p(HGNC:TUBB4A) |
| pubmed:30515821 | p(HGNC:LRRK2) regulates a(MESH:"Transport Vesicles") |
| pubmed:30515821 | p(HGNC:LRRK2) regulates bp(GO:autophagy) |
| pubmed:30515821 | p(HGNC:LRRK2) regulates path(NCIT:C17741) |
| pubmed:30515821 | p(HGNC:LRRK2) regulates path(MESH:"Neurotoxicity Syndromes") |
| pubmed:30515821 | p(HGNC:LRRK2) regulates path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | p(HGNC:LRRK2) increases bp(GO:"mitochondrial fission") |
| pubmed:30688256 | p(HGNC:LRRK2) decreases bp(GO:"apoptotic process") |
| pubmed:30688256 | p(HGNC:LRRK2) increases act(a(MESH:Mitochondria)) |
| pubmed:30688256 | p(HGNC:LRRK2) decreases path(MESH:"Oxidative Stress") |
| pubmed:30688256 | p(HGNC:LRRK2) increases bp(GO:mitophagy) |
| pubmed:24113872 | act(p(HGNC:LRRK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 149)) |
| pubmed:24113872 | act(p(HGNC:LRRK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 153)) |
| pubmed:24113872 | act(p(HGNC:LRRK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:24113872 | act(p(HGNC:LRRK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(CONSO:"Tau aggregates") |
| pubmed:24113872 | act(p(HGNC:LRRK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:24113872 | act(p(HGNC:LRRK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:30663117 | p(HGNC:LRRK2, var("?")) increases bp(GO:"neuron death") |
| pubmed:21722302 | p(HGNC:LRRK2, var("?")) increases path(DOID:"autosomal dominant Parkinson's disease 1") |
| pubmed:21722302 | p(HGNC:LRRK2, var("?")) decreases bp(GO:"protein catabolic process") |
| pubmed:21722302 | p(HGNC:LRRK2, var("?")) increases a(CONSO:"alpha-synuclein aggregates") |
| pubmed:21722302 | p(HGNC:LRRK2, var("?")) increases a(MESH:"Ubiquitinated Proteins") |
| pubmed:21722302 | p(HGNC:LRRK2, var("?")) decreases bp(GO:"lysosomal protein catabolic process") |
| pubmed:21722302 | p(HGNC:LRRK2, var("?")) decreases bp(GO:"regulation of protein oxidation") |
| pubmed:21722302 | p(HGNC:LRRK2, var("?")) increases bp(GO:"inflammatory response") |
| pubmed:21722302 | p(HGNC:LRRK2, var("?")) increases bp(MESH:Apoptosis) |
| pubmed:30116051 | p(HGNC:LRRK2, var("?")) association path(MESH:"Parkinson Disease") |
| pubmed:30116051 | p(HGNC:LRRK2, var("?")) decreases bp(GO:autophagy) |
| pubmed:30116051 | p(HGNC:LRRK2, var("?")) decreases act(p(HGNC:BECN1)) |
| pubmed:30116051 | p(HGNC:LRRK2, var("?")) association bp(CONSO:"APP processing") |
| pubmed:30116051 | p(HGNC:LRRK2, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:30663117 | p(HGNC:LRRK2, var("p.Gly2019Ser")) increases path(MESH:"Parkinson Disease") |
| pubmed:30515821 | p(HGNC:LRRK2, var("p.Gly2019Ser")) increases act(p(HGNC:LRRK2), ma(GO:"kinase activity")) |
| pubmed:30515821 | p(HGNC:LRRK2, var("p.Gly2019Ser")) increases path(DOID:"Parkinson's disease") |
| pubmed:30515821 | p(HGNC:LRRK2, var("p.Gly2019Ser")) increases bp(GO:"mitochondrial fission") |
| pubmed:28803412 | p(HGNC:LRRK2, var("p.Gly2019Ser")) increases path(MESH:"Neurodegenerative Diseases") |
| pubmed:30663117 | g(HGNC:MIR205) regulates p(HGNC:LRRK2) |
| pubmed:30663117 | g(HGNC:MIR205) regulates p(HGNC:LRRK2) |
| pubmed:30663117 | g(HGNC:MIRLET7A1) decreases p(HGNC:E2F1) |
| pubmed:30663117 | g(HGNC:MIRLET7A1) decreases act(p(HGNC:E2F1)) |
| pubmed:30663117 | g(HGNC:MIRLET7A1) decreases p(HGNC:TFDP1) |
| pubmed:30663117 | g(HGNC:MIRLET7A1) decreases act(p(HGNC:TFDP1)) |
| pubmed:30663117 | g(HGNC:MIR184) decreases p(HGNC:E2F1) |
| pubmed:30663117 | g(HGNC:MIR184) decreases act(p(HGNC:E2F1)) |
| pubmed:30663117 | g(HGNC:MIR184) decreases p(HGNC:TFDP1) |
| pubmed:30663117 | g(HGNC:MIR184) decreases act(p(HGNC:TFDP1)) |
| pubmed:30663117 | p(HGNC:PARK7) decreases a(CONSO:"alpha-synuclein aggregates") |
| pubmed:30663117 | p(HGNC:PARK7) decreases bp(GO:"apoptotic process") |
| pubmed:30688256 | p(HGNC:PARK7) decreases bp(GO:"apoptotic process") |
| pubmed:30663117 | p(HGNC:PARK7) decreases bp(GO:"neuron death") |
| pubmed:30688256 | p(HGNC:PARK7) increases act(a(MESH:Mitochondria)) |
| pubmed:30688256 | p(HGNC:PARK7) decreases path(MESH:"Oxidative Stress") |
| pubmed:30688256 | p(HGNC:PARK7) increases bp(GO:mitophagy) |
| pubmed:21722302 | p(HGNC:PARK7) increases bp(GO:"detection of redox state") |
| pubmed:21722302 | p(HGNC:PARK7) regulates bp(MESH:"Protein Stability") |
| pubmed:30562574 | p(HGNC:PARK7) association path(MESH:"Parkinson Disease") |
| pubmed:30562574 | p(HGNC:PARK7) isA a(MESH:Antioxidants) |
| pubmed:30562574 | p(HGNC:PARK7) increases path(MESH:"Neuronal Outgrowth") |
| pubmed:30562574 | p(HGNC:PARK7) increases bp(GO:"neuron projection development") |
| pubmed:30562574 | p(HGNC:PARK7) association path(DOID:"Parkinson's disease") |
| pubmed:30562574 | p(HGNC:PARK7) association path(DOID:"Parkinson's disease") |
| pubmed:30562574 | p(HGNC:PARK7) isA a(CHEBI:antioxidant) |
| pubmed:30562574 | p(HGNC:PARK7) association path(MESH:"Neurodegenerative Diseases") |
| pubmed:30562574 | p(HGNC:PARK7) association bp(GO:"mitochondrial depolarization") |
| pubmed:30562574 | p(HGNC:PARK7) increases bp(GO:"cellular response to oxidative stress") |
| pubmed:30663117 | path(MESH:Chorea) association path(MESH:"Huntington Disease") |
| pubmed:29687724 | path(MESH:Chorea) association path(MESH:"Huntington Disease") |
| pubmed:29687724 | path(MESH:Chorea) association path(MESH:"Neural Pathways") |
| pubmed:29687724 | path(MESH:Chorea) association a(CHEBI:dopamine) |
| pubmed:30988501 | path(MESH:Chorea) increases path(MESH:"Movement Disorders") |
| pubmed:30988501 | path(MESH:Chorea) association path(DOID:"rheumatic fever") |
| pubmed:30663117 | path(MESH:Dementia) association path(MESH:"Huntington Disease") |
| pubmed:30012004 | path(MESH:Dementia) positiveCorrelation path(MESH:"Huntington Disease") |
| pubmed:22236693 | path(MESH:Dementia) association g(HGNC:NGFR) |
| pubmed:19126755 | path(MESH:Dementia) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19293145 | path(MESH:Dementia) association path(MESH:"Alzheimer Disease") |
| pubmed:24511233 | path(MESH:Dementia) association path(MESH:"Alzheimer Disease") |
| pubmed:25514383 | path(MESH:Dementia) association path(MESH:"Alzheimer Disease") |
| pubmed:26813123 | path(MESH:Dementia) association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:25514383 | path(MESH:Dementia) association bp(GO:aging) |
| pubmed:18986241 | path(MESH:Dementia) association path(CONSO:aMCI) |
| pubmed:18986241 | path(MESH:Dementia) association path(MESH:"Cholinergic Neurons") |
| pubmed:18986241 | path(MESH:Dementia) decreases p(HGNC:ACHE) |
| pubmed:29758300 | path(MESH:Dementia) association path(MESH:Tauopathies) |
| pubmed:22908190 | path(MESH:Dementia) positiveCorrelation a(GO:"Lewy body") |
| pubmed:22908190 | path(MESH:Dementia) positiveCorrelation a(GO:"Lewy body") |
| pubmed:22908190 | path(MESH:Dementia) positiveCorrelation p(HGNC:SNCA, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:26091809 | path(MESH:Dementia) increases path(MESH:Mortality) |
| pubmed:27314526 | path(MESH:Dementia) association tloc(a(MESH:Interleukins), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27314526 | path(MESH:Dementia) positiveCorrelation p(HGNC:IL1B) |
| pubmed:27314526 | path(MESH:Dementia) positiveCorrelation p(HGNC:IL18) |
| pubmed:30663117 | path(MESH:"Deglutition Disorders") association path(MESH:"Huntington Disease") |
| pubmed:30663117 | path(MESH:Aphasia) association path(MESH:"Huntington Disease") |
| pubmed:30663117 | path(MESH:Seizures) association path(MESH:"Huntington Disease") |
| pubmed:30515821 | path(MESH:Seizures) increases path(MESH:"Wounds and Injuries") |
| pubmed:21787755 | path(MESH:Seizures) association p(CONSO:"alpha-7-containing nAChR") |
| pubmed:30663117 | p(HGNC:HTT, var("?")) increases path(MESH:"Huntington Disease") |
| pubmed:14556719 | p(HGNC:HTT, var("?")) increases path(MESH:"Huntington Disease") |
| pubmed:30515821 | p(HGNC:HTT, var("?")) increases a(CHEBI:"nitric oxide") |
| pubmed:14556719 | p(HGNC:HTT, var("?")) increases a(CONSO:"huntingtin aggregates") |
| pubmed:14556719 | p(HGNC:HTT, var("?")) decreases act(complex(GO:"proteasome complex")) |
| pubmed:14556719 | p(HGNC:HTT, var("?")) increases bp(GO:"cell cycle arrest") |
| pubmed:14556719 | p(HGNC:HTT, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:14556719 | p(HGNC:HTT, var("?")) decreases act(p(CONSO:"20 S Proteasome")) |
| pubmed:14556719 | p(HGNC:HTT, var("?")) decreases deg(p(HGNC:TP53)) |
| pubmed:14556719 | p(HGNC:HTT, var("?")) decreases bp(MESH:"Membrane Potential, Mitochondrial") |
| pubmed:14556719 | p(HGNC:HTT, var("?")) increases tloc(a(CHEBI:"cytochrome c"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:14556719 | p(HGNC:HTT, var("?")) increases act(p(FPLX:Caspase)) |
| pubmed:14556719 | p(HGNC:HTT, var("?")) increases bp(GO:"apoptotic process") |
| pubmed:25784053 | p(HGNC:HTT, var("?")) increases p(FPLX:HSPA) |
| pubmed:30116051 | p(HGNC:HTT, var("?")) decreases bp(GO:autophagy) |
| pubmed:30116051 | p(HGNC:HTT, var("?")) decreases bp(GO:"cargo loading into vesicle") |
| pubmed:30116051 | p(HGNC:HTT, var("?")) decreases bp(GO:"autophagosome assembly") |
| pubmed:27181519 | p(HGNC:HTT, var("?")) increases p(HGNC:HTT, pmod(CONSO:"protein aggregation")) |
| pubmed:23516100 | p(HGNC:HTT) increases p(HGNC:HTT, frag("?")) |
| pubmed:23516100 | p(HGNC:HTT) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) |
| pubmed:23516100 | p(HGNC:HTT) increases act(p(HGNCGENEFAMILY:Calpains)) |
| pubmed:23516100 | p(HGNC:HTT) decreases act(p(HGNC:CASP3)) |
| pubmed:30688256 | p(HGNC:HTT) association bp(GO:mitophagy) |
| pubmed:30362565 | act(p(HGNC:HTT)) increases p(HGNC:BDNF) |
| pubmed:30985105 | p(HGNC:HTT) association p(HGNC:BDNF) |
| pubmed:30362565 | act(p(HGNC:HTT)) increases path(MESH:"Transport Vesicles") |
| pubmed:30362565 | p(HGNC:HTT) regulates path(MESH:Autophagy) |
| pubmed:30027901 | act(p(HGNC:HTT)) association bp(GO:"intracellular transport") |
| pubmed:30027901 | p(HGNC:HTT) association bp(GO:"intracellular transport") |
| pubmed:30027901 | act(p(HGNC:HTT)) association bp(GO:endocytosis) |
| pubmed:30027901 | act(p(HGNC:HTT)) increases bp(GO:"chemical synaptic transmission") |
| pubmed:30027901 | act(p(HGNC:HTT)) increases bp(GO:"mRNA transcription") |
| pubmed:23393546 | p(HGNC:HTT) increases bp(GO:"mRNA transcription") |
| pubmed:30027901 | act(p(HGNC:HTT)) association bp(GO:autophagy) |
| pubmed:30027901 | p(HGNC:HTT) association bp(GO:autophagy) |
| pubmed:30027901 | p(HGNC:HTT) increases p(HGNC:HTT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30027901 | p(HGNC:HTT) increases p(HGNC:HTT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30027901 | p(HGNC:HTT) increases p(HGNC:HTT, pmod(go:0018345 ! "protein palmitoylation")) |
| pubmed:30027901 | p(HGNC:HTT) increases p(HGNC:HTT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:30027901 | p(HGNC:HTT) increases p(HGNC:HTT, pmod(go:0016925 ! "protein sumoylation")) |
| pubmed:30027901 | p(HGNC:HTT) increases tloc(a(MESH:Autophagosomes), fromLoc(GO:"distal axon"), toLoc(GO:"cell body")) |
| pubmed:30027901 | p(HGNC:HTT) association a(MESH:Autophagosomes) |
| pubmed:30027901 | p(HGNC:HTT) regulates deg(p(HGNC:HTT)) |
| pubmed:30027901 | p(HGNC:HTT) association a(MESH:Lysosomes) |
| pubmed:30027901 | p(HGNC:HTT) association a(MESH:"Synaptic Vesicles") |
| pubmed:30027901 | p(HGNC:HTT) association composite(a(MESH:"Cytoplasmic Vesicles"), p(HGNC:BDNF)) |
| pubmed:30027901 | p(HGNC:HTT) association composite(a(CHEBI:"gamma-aminobutyric acid"), a(MESH:"Cytoplasmic Vesicles")) |
| pubmed:30027901 | p(HGNC:HTT) association bp(GO:"clathrin-dependent endocytosis") |
| pubmed:30027901 | p(HGNC:HTT) increases p(HGNC:RAB11A) |
| pubmed:30027901 | p(HGNC:HTT) increases bp(GO:"cytosolic ciliogenesis") |
| pubmed:23393546 | p(HGNC:HTT) increases p(MESH:"Transport Vesicles") |
| pubmed:23393546 | p(HGNC:HTT) increases path(MESH:"Energy Metabolism") |
| pubmed:23393546 | p(HGNC:HTT) increases bp(GO:"embryo development") |
| pubmed:19933700 | p(HGNC:HTT) decreases r(HGNC:HOXB1) |
| pubmed:19933700 | p(HGNC:HTT) decreases r(HGNC:HOXB2) |
| pubmed:19933700 | p(HGNC:HTT) decreases r(HGNC:HOXB9) |
| pubmed:19933700 | p(HGNC:HTT) increases path(MESH:"Cell Differentiation") |
| pubmed:19933700 | p(HGNC:HTT) association p(CONSO:"Histone H3", pmod(mod:00430 ! "trimethylated residue", Lys, 27)) |
| pubmed:19933700 | p(HGNC:HTT) causesNoChange p(CONSO:"Histone H3", pmod(mod:00429 ! "dimethylated residue", Lys, 27)) |
| pubmed:19933700 | p(HGNC:HTT) increases complex(p(HGNC:EZH2), p(HGNC:HTT), p(HGNC:SUZ12)) |
| pubmed:26968346 | p(HGNC:HTT) association bp(GO:"selective autophagy") |
| pubmed:14556719 | p(HGNC:HTT) increases complex(p(HGNC:HTT), p(HGNC:UBA2)) |
| pubmed:30985105 | p(HGNC:HTT) association bp(GO:"vesicle transport along microtubule") |
| pubmed:30985105 | p(HGNC:HTT) decreases bp(GO:"apoptotic process") |
| pubmed:30663117 | g(HGNC:MIR196A1) association path(MESH:"Huntington Disease") |
| pubmed:30663117 | g(HGNC:MIR206) association path(MESH:"Huntington Disease") |
| pubmed:30663117 | g(HGNC:MIR301B) association path(MESH:"Huntington Disease") |
| pubmed:30663117 | g(HGNC:MIR92B) association path(MESH:"Huntington Disease") |
| pubmed:30663117 | g(HGNC:MIR378B) association path(MESH:"Huntington Disease") |
| pubmed:30663117 | g(HGNC:MIR208B) association path(MESH:"Huntington Disease") |
| pubmed:30663117 | g(HGNC:MIR449A) association path(MESH:"Huntington Disease") |
| pubmed:30663117 | g(HGNC:MIR22) decreases bp(GO:"neuron death") |
| pubmed:16273023 | act(a(CHEBI:acetylcholine)) association a(CHEBI:acetylcholine) |
| pubmed:16273023 | a(CHEBI:acetylcholine) association act(a(CHEBI:acetylcholine)) |
| pubmed:17009926 | deg(a(CHEBI:acetylcholine)) decreases act(a(CHEBI:acetylcholine)) |
| pubmed:26218288 | a(CHEBI:acetylcholine) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26218288 | a(CHEBI:acetylcholine) positiveCorrelation a(CHEBI:"ginsenoside Re") |
| pubmed:26218288 | a(CHEBI:acetylcholine) positiveCorrelation a(CHEBI:"ginsenoside Rd") |
| pubmed:21673407 | tloc(a(CHEBI:acetylcholine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association p(HGNC:HTR4) |
| pubmed:19126755 | a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) |
| pubmed:24590577 | a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) |
| pubmed:19126755 | a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:24590577 | a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19126755 | a(CHEBI:acetylcholine) decreases bp(MESH:"Heart Rate") |
| pubmed:19126755 | a(CHEBI:acetylcholine) association bp(GO:signaling) |
| pubmed:24511233 | a(CHEBI:acetylcholine) regulates act(a(MESH:Neurons)) |
| pubmed:24511233 | act(a(CHEBI:acetylcholine)) increases act(p(HGNC:CHRM4)) |
| pubmed:17009926 | a(CHEBI:acetylcholine) increases act(p(HGNC:CHRNA7)) |
| pubmed:26979166 | a(CHEBI:acetylcholine) increases act(p(HGNC:CHRNA7, loc(MESH:Microglia))) |
| pubmed:17009926 | a(CHEBI:acetylcholine) increases bp(GO:"regulation of action potential firing rate") |
| pubmed:26813123 | a(CHEBI:acetylcholine) isA a(CHEBI:neurotransmitter) |
| pubmed:26813123 | a(CHEBI:acetylcholine) positiveCorrelation bp(GO:memory) |
| pubmed:26813123 | a(CHEBI:acetylcholine) regulates bp(GO:memory) |
| pubmed:26813123 | a(CHEBI:acetylcholine) association bp(GO:memory) |
| pubmed:26813123 | a(CHEBI:acetylcholine) regulates a(MESH:"Hypothalamo-Hypophyseal System") |
| pubmed:26813123 | a(CHEBI:acetylcholine) increases act(a(MESH:"Receptors, Nicotinic")) |
| pubmed:26813123 | a(CHEBI:acetylcholine) increases bp(GO:"response to auditory stimulus") |
| pubmed:26813123 | a(CHEBI:acetylcholine) increases bp(GO:"synaptic transmission, cholinergic") |
| pubmed:26813123 | a(CHEBI:acetylcholine) increases bp(GO:neurogenesis) |
| pubmed:26813123 | a(CHEBI:acetylcholine) increases act(p(FPLX:CHRM)) |
| pubmed:21482353 | a(CHEBI:acetylcholine) increases act(p(FPLX:CHRM)) |
| pubmed:26813123 | a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN)) |
| pubmed:21482353 | a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN)) |
| pubmed:21787755 | a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN)) |
| pubmed:26813123 | deg(a(CHEBI:acetylcholine)) increases a(CHEBI:choline) |
| pubmed:26813123 | a(CHEBI:acetylcholine) regulates bp(MESH:"Synaptic Transmission") |
| pubmed:26813123 | a(CHEBI:acetylcholine) regulates bp(GO:"synaptic transmission, glutamatergic") |
| pubmed:26813123 | a(CHEBI:acetylcholine) association bp(GO:learning) |
| pubmed:26813123 | a(CHEBI:acetylcholine) association bp(GO:cognition) |
| pubmed:11230871 | a(CHEBI:acetylcholine) negativeCorrelation bp(GO:cognition) |
| pubmed:16273023 | a(CHEBI:acetylcholine) increases complex(a(CHEBI:acetylcholine), p(MESH:D011950)) |
| pubmed:25514383 | tloc(a(CHEBI:acetylcholine), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) regulates bp(GO:"long-term memory") |
| pubmed:25514383 | a(CHEBI:acetylcholine) increases act(p(CONSO:"beta-2-containing nAChR")) |
| pubmed:25514383 | act(a(CHEBI:acetylcholine)) increases act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:28445721 | a(CHEBI:acetylcholine) increases act(a(MESH:"nicotinic receptor alpha3beta4")) |
| pubmed:21482353 | a(CHEBI:acetylcholine) increases act(p(CONSO:"alpha-7-containing nAChR")) |
| pubmed:19721446 | a(CHEBI:acetylcholine) association bp(GO:"regulation of cation channel activity") |
| pubmed:19721446 | a(CHEBI:acetylcholine) increases bp(GO:"potassium ion transport") |
| pubmed:19721446 | a(CHEBI:acetylcholine) increases bp(GO:"sodium ion transport") |
| pubmed:19721446 | a(CHEBI:acetylcholine) increases bp(GO:"calcium ion transport") |
| pubmed:16273023 | a(CL:"cholinergic neuron") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:16273023 | act(p(HGNC:ACHE)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26813123 | p(HGNC:ACHE) association path(MESH:"Alzheimer Disease") |
| pubmed:11230871 | act(p(HGNC:ACHE)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:3484831 | p(HGNC:ACHE) positiveCorrelation a(NIFT:"Cerebral atrophy") |
| pubmed:3484831 | p(HGNC:ACHE) positiveCorrelation a(NIFT:"Cerebral atrophy") |
| pubmed:19126755 | p(HGNC:ACHE) decreases act(a(CHEBI:nicotine)) |
| pubmed:19126755 | act(p(HGNC:ACHE)) decreases a(MESH:Acetylcholine) |
| pubmed:19293145 | p(HGNC:ACHE) decreases a(CHEBI:acetylcholine) |
| pubmed:17009926 | act(p(HGNC:ACHE), ma(go:0008233 ! "peptidase activity")) directlyIncreases deg(a(CHEBI:acetylcholine)) |
| pubmed:26813123 | p(HGNC:ACHE) decreases act(a(CHEBI:acetylcholine)) |
| pubmed:21482353 | p(HGNC:ACHE) increases deg(a(CHEBI:acetylcholine)) |
| pubmed:23038257 | p(HGNC:ACHE) increases act(a(CHEBI:chlorpromazine)) |
| pubmed:17009926 | act(p(HGNC:ACHE), ma(go:0008233 ! "peptidase activity")) directlyIncreases rxn(reactants(a(CHEBI:acetylcholine)), products(a(CHEBI:acetate), a(CHEBI:choline))) |
| pubmed:26813123 | p(HGNC:ACHE) increases rxn(reactants(a(CHEBI:acetylcholine)), products(a(CHEBI:acetate), a(CHEBI:choline))) |
| pubmed:26813123 | p(HGNC:ACHE) increases a(CHEBI:amyloid-beta) |
| pubmed:25514383 | act(p(HGNC:ACHE)) increases bp(GO:"acetylcholine catabolic process") |
| pubmed:21482353 | act(p(HGNC:ACHE)) decreases bp(GO:"synaptic transmission, cholinergic") |
| pubmed:18986241 | p(HGNC:ACHE) association path(MESH:"Plaque, Amyloid") |
| pubmed:18986241 | p(HGNC:ACHE) increases bp(GO:"amyloid fibril formation") |
| pubmed:16273023 | p(HGNC:REST) association path(MESH:"Alzheimer Disease") |
| pubmed:16273023 | p(HGNC:REST) association path(MESH:Stroke) |
| pubmed:16273023 | p(HGNC:REST) association path(MESH:Epilepsy) |
| pubmed:16273023 | p(HGNC:REST) negativeCorrelation tloc(a(CHEBI:"insulin (human)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:16273023 | p(HGNC:REST) decreases a(CHEBI:"insulin (human)") |
| pubmed:16273023 | path(MESH:Stroke) association p(HGNC:REST) |
| pubmed:24561250 | path(MESH:Stroke) increases complex(GO:"inflammasome complex") |
| pubmed:16273023 | path(MESH:Epilepsy) association p(HGNC:REST) |
| pubmed:17009926 | path(MESH:Epilepsy) association p(FPLX:CHRN) |
| pubmed:17009926 | path(MESH:Epilepsy) association p(FPLX:CHRN) |
| pubmed:11230871 | path(MESH:Epilepsy) association p(FPLX:CHRN) |
| pubmed:21482353 | path(MESH:Epilepsy) positiveCorrelation p(HGNC:CHRNA4, var("?")) |
| pubmed:21482353 | path(MESH:Epilepsy) positiveCorrelation p(HGNC:CHRNB2, var("?")) |
| pubmed:21787755 | path(MESH:Epilepsy) association complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| pubmed:28901280 | path(MESH:Epilepsy) association p(MESH:"Receptors, Nicotinic") |
| pubmed:16273023 | tloc(a(CHEBI:"insulin (human)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) negativeCorrelation p(HGNC:REST) |
| pubmed:22908190 | a(CHEBI:"insulin (human)") regulates p(HGNC:MTOR) |
| pubmed:16273023 | p(RGD:Gsk3b) regulates p(HGNCGENEFAMILY:"Glutamate ionotropic receptor AMPA type subunits") |
| pubmed:16273023 | p(RGD:Gsk3b) increases bp(MESH:"Long-Term Synaptic Depression") |
| pubmed:16273023 | p(HGNCGENEFAMILY:"Protein phosphatase catalytic subunits") increases p(RGD:Gsk3b) |
| pubmed:18986241 | p(HGNCGENEFAMILY:"Protein phosphatase catalytic subunits") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:18986241 | act(p(HGNCGENEFAMILY:"Protein phosphatase catalytic subunits")) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:16273023 | p(HGNC:SEPT2) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:16273023 | p(HGNC:SEPT2) regulates bp(MESH:"Neuronal Plasticity") |
| pubmed:16273023 | p(HGNC:SEPT2) association p(HGNC:SLC1A3) |
| pubmed:16273023 | p(HGNC:SEPT3) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:16273023 | p(HGNC:SEPT5) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:14556719 | p(HGNC:SEPT5) decreases tloc(a(CHEBI:"growth hormone"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:14556719 | p(HGNC:SEPT5) regulates tloc(a(CHEBI:neurotransmitter), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:14556719 | p(HGNC:SEPT5) regulates act(a(GO:"synaptic vesicle")) |
| pubmed:16273023 | p(RGD:Sept5) association p(RGD:Stx1a) |
| pubmed:16273023 | p(RGD:Sept5) decreases bp(GO:exocytosis) |
| pubmed:16273023 | act(p(RGD:Sept5)) negativeCorrelation act(p(RGD:Cdk5)) |
| pubmed:16273023 | p(RGD:Stx1a) association p(RGD:Sept5) |
| pubmed:16273023 | p(RGD:Stx1a) association bp(GO:exocytosis) |
| pubmed:16273023 | bp(GO:exocytosis) association p(RGD:Stx1a) |
| pubmed:16273023 | p(RGD:Cdk5) increases p(RGD:Sept5, pmod(go:0006468 ! "protein phosphorylation", Ser, 161)) |
| pubmed:16273023 | p(RGD:Cdk5) increases p(RGD:Sept5, pmod(go:0006468 ! "protein phosphorylation", Ser, 327)) |
| pubmed:16273023 | act(p(RGD:Cdk5)) negativeCorrelation act(p(RGD:Sept5)) |
| pubmed:27807169 | act(p(RGD:Cdk5)) positiveCorrelation bp(GO:"neuron differentiation") |
| pubmed:21489990 | act(p(RGD:Cdk5)) increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:21489990 | act(p(RGD:Cdk5)) increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:21489990 | act(p(RGD:Cdk5)) increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:24107444 | bp(MESH:"Neuronal Plasticity") positiveCorrelation p(MGI:Psen1) |
| pubmed:24107444 | bp(MESH:"Neuronal Plasticity") positiveCorrelation a(CHEBI:"calcium(2+)") |
| pubmed:19126755 | bp(MESH:"Neuronal Plasticity") association act(p(FPLX:CREB)) |
| pubmed:19126755 | bp(MESH:"Neuronal Plasticity") association act(p(HGNC:MAPK1)) |
| pubmed:29428175 | bp(MESH:"Neuronal Plasticity") association p(MESH:"Receptors, Glutamate", loc(GO:"postsynaptic membrane")) |
| pubmed:30697142 | bp(MESH:"Neuronal Plasticity") association bp(GO:"learning or memory") |
| pubmed:18986241 | bp(MESH:"Neuronal Plasticity") association act(p(HGNC:GAL)) |
| pubmed:24760868 | bp(MESH:"Neuronal Plasticity") association tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) |
| pubmed:28420982 | bp(MESH:"Neuronal Plasticity") increases tloc(p(HGNC:MAPT), fromLoc(GO:cell), toLoc(GO:cell)) |
| pubmed:28420982 | bp(MESH:"Neuronal Plasticity") association a(CONSO:"Tau aggregates") |
| pubmed:16273023 | p(HGNC:SLC1A3) association p(HGNC:SEPT2) |
| pubmed:17361039 | p(HGNC:SLC1A3) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:17361039 | p(HGNC:SLC1A3) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23340677 | p(MGI:Mapt) positiveCorrelation a(CHEBI:"L-glutamic acid") |
| pubmed:23340677 | p(MGI:Mapt) negativeCorrelation bp(MESH:Metabolism) |
| pubmed:21427723 | p(MGI:Mapt) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:21427723 | p(MGI:Mapt) increases p(CONSO:"Tau fibrils") |
| pubmed:21427723 | p(MGI:Mapt) decreases p(CONSO:"Tau fibrils") |
| pubmed:21427723 | act(p(MGI:Mapt)) increases a(MESH:Microtubules) |
| pubmed:21427723 | act(p(MGI:Mapt)) positiveCorrelation bp(GO:"microtubule bundle formation") |
| pubmed:29024336 | p(MGI:Mapt) decreases bp(GO:"late endosomal microautophagy") |
| pubmed:29202785 | p(MGI:Mapt) increases bp(GO:"neuron migration") |
| pubmed:29202785 | p(MGI:Mapt) increases bp(GO:"neuron differentiation") |
| pubmed:29202785 | p(MGI:Mapt) increases bp(GO:"neuron maturation") |
| pubmed:30126037 | p(MGI:Mapt) increases a(GO:"neurofibrillary tangle") |
| pubmed:30126037 | p(MGI:Mapt) increases bp(HP:Neurodegeneration) |
| pubmed:30126037 | p(MGI:Mapt) increases p(MGI:Cdkn2a) |
| pubmed:30126037 | p(MGI:Mapt) increases bp(GO:"cellular senescence") |
| pubmed:30126037 | p(MGI:Mapt) increases path(HP:"Brain atrophy") |
| pubmed:28408124 | tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) increases a(CONSO:"Tau aggregates") |
| pubmed:18096814 | p(MGI:Mapt, loc(GO:"membrane raft")) negativeCorrelation a(CHEBI:"2-bromohexadecanoic acid") |
| pubmed:19118186 | p(MGI:Mapt) negativeCorrelation bp(GO:memory) |
| pubmed:29221819 | p(MGI:Mapt) positiveCorrelation p(MGI:Dyrk1a) |
| pubmed:28877763 | p(MGI:Mapt) positiveCorrelation p(MGI:Syk) |
| pubmed:23340677 | a(CHEBI:"L-glutamic acid") positiveCorrelation p(MGI:Mapt) |
| pubmed:24107444 | tloc(a(CHEBI:"L-glutamic acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) positiveCorrelation p(MGI:Psen1) |
| pubmed:24107444 | tloc(a(CHEBI:"L-glutamic acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) positiveCorrelation a(CHEBI:"calcium(2+)") |
| pubmed:23340677 | bp(MESH:Metabolism) negativeCorrelation p(MGI:Mapt) |
| pubmed:" 23273601" | r(HGNC:VAMP2) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:" 23273601" | r(HGNC:SNAP25) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:" 23273601" | r(HGNC:SYN1) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:" 23273601" | r(HGNC:SYN2) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:" 23273601" | r(HGNC:SYT1) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:" 23273601" | r(HGNC:SYT5) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:" 23273601" | r(HGNC:DNM1) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:" 23273601" | r(HGNC:DNM1L) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:" 23273601" | r(HGNC:SYNPO) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:" 23273601" | r(HGNC:RAB3A) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:" 23273601" | r(HGNC:SEC22B) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:" 23273601" | r(HGNC:SNCB) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:" 23273601" | r(HGNC:STXBP5L) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:" 23273601" | r(HGNC:STXBP6) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:" 23273601" | r(HGNC:BSN) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:" 23273601" | r(HGNC:PCLO) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:" 23273601" | r(HGNC:SNAP23) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:" 23273601" | r(HGNC:SYNPO2) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:" 23273601" | r(HGNC:VAMP1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26218288 | p(RGD:App) decreases r(RGD:Grin1) |
| pubmed:26218288 | p(RGD:App) decreases r(RGD:Grm1) |
| pubmed:26218288 | p(RGD:App) decreases r(RGD:Kcnj6) |
| pubmed:26218288 | p(RGD:App) decreases r(RGD:Kcnj9) |
| pubmed:26218288 | p(RGD:App) decreases r(RGD:Kcnj5) |
| pubmed:26218288 | p(RGD:App) decreases r(RGD:Kcnq2) |
| pubmed:26218288 | p(RGD:App) decreases r(RGD:Kcnq3) |
| pubmed:26218288 | path(HP:"Neuronal loss in central nervous system") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26218288 | a(CHEBI:"ginsenoside Re") increases r(MGI:Chat) |
| pubmed:26218288 | a(CHEBI:"ginsenoside Re") increases r(MGI:Slc18a3) |
| pubmed:26218288 | a(CHEBI:"ginsenoside Re") positiveCorrelation a(CHEBI:acetylcholine) |
| pubmed:26218288 | a(CHEBI:"ginsenoside Re") increases p(MGI:Map2) |
| pubmed:26218288 | a(CHEBI:"ginsenoside Re") increases p(MGI:Ngfr) |
| pubmed:26218288 | a(CHEBI:"ginsenoside Re") increases p(MGI:Cdkn1a) |
| pubmed:26218288 | a(CHEBI:"ginsenoside Re") increases p(MGI:Ntrk1) |
| pubmed:26218288 | a(CHEBI:"ginsenoside Rd") increases r(MGI:Chat) |
| pubmed:26218288 | a(CHEBI:"ginsenoside Rd") increases r(MGI:Slc18a3) |
| pubmed:26218288 | a(CHEBI:"ginsenoside Rd") positiveCorrelation a(CHEBI:acetylcholine) |
| pubmed:26218288 | a(CHEBI:"ginsenoside Rd") increases p(MGI:Map2) |
| pubmed:26218288 | a(CHEBI:"ginsenoside Rd") increases p(MGI:Ngfr) |
| pubmed:26218288 | a(CHEBI:"ginsenoside Rd") increases p(MGI:Cdkn1a) |
| pubmed:26218288 | a(CHEBI:"ginsenoside Rd") increases p(MGI:Ntrk1) |
| pubmed:26218288 | a(CHEBI:K-252a) decreases p(MGI:Mapk1) |
| pubmed:26218288 | a(CHEBI:K-252a) decreases p(MGI:Akt1) |
| pubmed:26218288 | a(CHEBI:K-252a) decreases p(MGI:Ntrk1) |
| pubmed:24107444 | g(HGNC:PSEN1) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24107444 | p(HGNC:PSEN1) isA complex(GO:"gamma-secretase complex") |
| pubmed:23091460 | p(HGNC:PSEN1) positiveCorrelation act(p(HGNCGENEFAMILY:"V-type ATPases")) |
| pubmed:23091460 | p(HGNC:PSEN1) positiveCorrelation bp(GO:autophagy) |
| pubmed:30688256 | act(p(HGNC:PSEN1)) increases bp(GO:autophagy) |
| pubmed:21214928 | p(HGNC:PSEN1) regulates p(HGNC:APP) |
| pubmed:22426017 | p(HGNC:PSEN1) increases bp(GO:"neuron death") |
| pubmed:19293145 | p(HGNC:PSEN1) causesNoChange path(CONSO:Neurodegeneration) |
| pubmed:19293145 | p(HGNC:PSEN1) association path(MESH:"Alzheimer Disease") |
| pubmed:26968346 | p(HGNC:PSEN1) positiveCorrelation bp(GO:"autophagosome-lysosome fusion") |
| pubmed:26968346 | p(HGNC:PSEN1) positiveCorrelation bp(GO:"endomembrane system organization") |
| pubmed:26968346 | p(HGNC:PSEN1) positiveCorrelation bp(GO:"sequestering of calcium ion") |
| pubmed:27299292 | p(HGNC:PSEN1, loc(GO:"excitatory synapse")) decreases p(HGNC:TFEB) |
| pubmed:27299292 | p(HGNC:PSEN1) increases act(p(HGNC:TFEB)) |
| pubmed:27299292 | p(HGNC:PSEN1) increases act(p(HGNC:TFEB)) |
| pubmed:27299292 | p(HGNC:PSEN1, loc(GO:"excitatory synapse")) regulates act(a(MESH:Lysosomes)) |
| pubmed:27299292 | p(HGNC:PSEN1) negativeCorrelation path(DOID:"Alzheimer's disease") |
| pubmed:27299292 | p(HGNC:PSEN1) increases p(HGNC:SESN2) |
| pubmed:27299292 | p(HGNC:PSEN1) decreases p(HGNCGENEFAMILY:"MTOR complex 1", loc(GO:"lysosomal membrane")) |
| pubmed:29758300 | p(HGNC:PSEN1) association bp(GO:"calcium ion homeostasis") |
| pubmed:29758300 | p(HGNC:PSEN1) association bp(GO:"regulation of lysosomal lumen pH") |
| pubmed:22908190 | p(HGNC:PSEN1) increases bp(GO:"pH reduction") |
| pubmed:22908190 | p(HGNC:PSEN1) increases act(a(MESH:Cathepsins)) |
| pubmed:22908190 | p(HGNC:PSEN1) increases p(HGNC:ATP6V0A1, pmod(go:0006487 ! "protein N-linked glycosylation")) |
| pubmed:24027553 | p(HGNC:PSEN1) increases bp(GO:"vacuolar acidification") |
| pubmed:24107444 | complex(GO:"gamma-secretase complex") association p(HGNC:NOTCH1) |
| pubmed:24107444 | complex(GO:"gamma-secretase complex") association p(HGNC:APP) |
| pubmed:28745240 | complex(GO:"gamma-secretase complex") regulates p(CONSO:C99) |
| pubmed:21861815 | complex(GO:"gamma-secretase complex") increases a(CHEBI:amyloid-beta) |
| pubmed:29758300 | complex(GO:"gamma-secretase complex") association a(CHEBI:amyloid-beta) |
| pubmed:21861815 | complex(GO:"gamma-secretase complex") increases a(CONSO:"amyloid-beta aggregates") |
| pubmed:29758300 | complex(GO:"gamma-secretase complex") increases p(HGNC:APP, frag("?")) |
| pubmed:29758300 | complex(GO:"gamma-secretase complex") association a(MESH:"Amyloid beta-Peptides") |
| pubmed:14556719 | complex(GO:"gamma-secretase complex") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta polypeptide 40"), a(CHEBI:"amyloid-beta polypeptide 42"))) |
| pubmed:14556719 | act(complex(GO:"gamma-secretase complex")) association p(HGNC:PSEN1, var("?")) |
| pubmed:14556719 | act(complex(GO:"gamma-secretase complex")) association p(HGNC:PSEN2, var("?")) |
| pubmed:24107444 | p(HGNC:NOTCH1) association complex(GO:"gamma-secretase complex") |
| pubmed:24107444 | p(MGI:Psen1) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pubmed:24107444 | p(MGI:Psen1) positiveCorrelation bp(MESH:"Neuronal Plasticity") |
| pubmed:24107444 | p(MGI:Psen1) positiveCorrelation tloc(a(CHEBI:"L-glutamic acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:24107444 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(MGI:Psen1) |
| pubmed:24107444 | bp(GO:"long-term synaptic potentiation") positiveCorrelation a(CHEBI:"calcium(2+)") |
| pubmed:28745240 | bp(GO:"long-term synaptic potentiation") association path(MESH:"Spatial Memory") |
| pubmed:28745240 | bp(GO:"long-term synaptic potentiation") decreases p(HGNC:NFKB1) |
| pubmed:28745240 | bp(GO:"long-term synaptic potentiation") decreases p(HGNC:RELA) |
| pubmed:29661268 | bp(GO:"long-term synaptic potentiation") negativeCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) |
| pubmed:29661268 | bp(GO:"long-term synaptic potentiation") negativeCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281)) |
| pubmed:21871088 | bp(GO:"long-term synaptic potentiation") decreases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pubmed:21871088 | bp(GO:"long-term synaptic potentiation") association bp(GO:"calcium ion import") |
| pubmed:21871088 | bp(GO:"long-term synaptic potentiation") association bp(GO:"cellular calcium ion homeostasis") |
| pubmed:19126755 | bp(GO:"long-term synaptic potentiation") increases bp(GO:"depolarization of postsynaptic membrane") |
| pubmed:19126755 | bp(GO:"long-term synaptic potentiation") increases bp(GO:"receptor clustering") |
| pubmed:24511233 | bp(GO:"long-term synaptic potentiation") association bp(GO:learning) |
| pubmed:24511233 | bp(GO:"long-term synaptic potentiation") association bp(GO:memory) |
| pubmed:21787755 | bp(GO:"long-term synaptic potentiation") association p(CONSO:"alpha-7-containing nAChR") |
| pubmed:22908190 | bp(GO:"long-term synaptic potentiation") negativeCorrelation act(p(HGNC:RAB5A)) |
| pubmed:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:MAPT) |
| pubmed:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) |
| pubmed:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:MAPT) |
| pubmed:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(MESH:Actins) |
| pubmed:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(MESH:Actins) |
| pubmed:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:FYN) |
| pubmed:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:GRIA1) |
| pubmed:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:GRIA1) |
| pubmed:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:DLG4) |
| pubmed:24760868 | bp(GO:"long-term synaptic potentiation") decreases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pubmed:24760868 | bp(GO:"long-term synaptic potentiation") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:24760868 | bp(GO:"long-term synaptic potentiation") increases p(HGNC:MAPT, var("p.Thr205Ala"), loc(MESH:"Dendritic Spines")) |
| pubmed:21882945 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:HSPB1) |
| pubmed:24107444 | p(MGI:Ncstn) isA complex(GO:"gamma-secretase complex") |
| pubmed:24107444 | p(MGI:Ncstn) positiveCorrelation bp(GO:memory) |
| pubmed:24107444 | p(MGI:Ncstn) negativeCorrelation path(HP:Neurodegeneration) |
| pubmed:24107444 | path(HP:Neurodegeneration) negativeCorrelation p(MGI:Ncstn) |
| pubmed:29179999 | path(HP:Neurodegeneration) association act(p(FPLX:NFkappaB)) |
| pubmed:27491084 | path(HP:Neurodegeneration) association p(HGNC:ATXN3, var("?")) |
| pubmed:27491084 | path(HP:Neurodegeneration) association p(HGNC:AR, var("?")) |
| pubmed:27491084 | path(HP:Neurodegeneration) association p(HGNC:SNCA, var("?")) |
| pubmed:23528736 | path(HP:Neurodegeneration) association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:29221819 | path(HP:Neurodegeneration) positiveCorrelation p(MGI:Dyrk1a) |
| pubmed:22483294 | g(DBSNP:rs4680) association g(HGNC:COMT) |
| pubmed:22483294 | g(DBSNP:rs4680) association path(MESH:"Psychotic Disorders") |
| pubmed:22483294 | g(DBSNP:rs4680) regulates path(MESH:"Memory, Episodic") |
| pubmed:22483294 | g(HGNC:COMT) association g(DBSNP:rs4680) |
| pubmed:22483294 | path(MESH:"Psychotic Disorders") association g(DBSNP:rs4680) |
| pubmed:24883238 | path(MESH:"Psychotic Disorders") positiveCorrelation g(DBSNP:rs3764640) |
| pubmed:30061532 | path(MESH:"Psychotic Disorders") association path(MESH:Schizophrenia) |
| pubmed:24511233 | path(MESH:"Psychotic Disorders") association path(MESH:Schizophrenia) |
| pubmed:30061532 | path(MESH:"Psychotic Disorders") association p(HGNC:SNCA, var("?")) |
| pubmed:30061532 | path(MESH:"Psychotic Disorders") association path(MESH:"Frontotemporal Lobar Degeneration") |
| pubmed:24511233 | path(MESH:"Psychotic Disorders") association path(MESH:"Alzheimer Disease") |
| pubmed:24511233 | path(MESH:"Psychotic Disorders") association path(MESH:"Alzheimer Disease") |
| pubmed:24511233 | path(MESH:"Psychotic Disorders") association path(MESH:"Alzheimer Disease") |
| pubmed:24590577 | path(MESH:"Psychotic Disorders") association p(HGNC:CHRM4) |
| pubmed:22040696 | path(MESH:"Psychotic Disorders") negativeCorrelation act(p(HGNC:RIC3), ma(go:0044183 ! "protein binding involved in protein folding")) |
| pubmed:22483294 | p(HGNC:COMT) positiveCorrelation a(CHEBI:homocysteine) |
| pubmed:22483294 | p(HGNC:COMT) negativeCorrelation bp(GO:"short-term memory") |
| pubmed:22483294 | a(CHEBI:homocysteine) positiveCorrelation p(HGNC:COMT) |
| pubmed:30962309 | a(CHEBI:homocysteine) increases path(EFO:"endothelial dysfunction") |
| pubmed:24524964 | a(CHEBI:homocysteine) association a(NIFT:"Hippocampus volume") |
| pubmed:24028866 | a(CHEBI:homocysteine) positiveCorrelation a(NIFT:"Hippocampal atrophy") |
| pubmed:24653673 | a(CHEBI:homocysteine) negativeCorrelation p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) |
| pubmed:24653673 | a(CHEBI:homocysteine) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | a(CHEBI:homocysteine) positiveCorrelation p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28632203 | a(CHEBI:homocysteine) biomarkerFor path(MESH:"Alzheimer Disease") |
| pubmed:22483294 | bp(GO:"short-term memory") negativeCorrelation p(HGNC:COMT) |
| pubmed:23091460 | act(p(HGNCGENEFAMILY:"V-type ATPases")) positiveCorrelation p(HGNC:PSEN1) |
| pubmed:23091460 | act(p(HGNCGENEFAMILY:"V-type ATPases")) positiveCorrelation bp(GO:autophagy) |
| pubmed:26968346 | p(HGNCGENEFAMILY:"V-type ATPases") regulates bp(GO:"lysosomal lumen acidification") |
| pubmed:26968346 | p(HGNCGENEFAMILY:"V-type ATPases") regulates bp(GO:"lysosomal protein catabolic process") |
| pubmed:23091460 | bp(GO:autophagy) positiveCorrelation act(p(HGNCGENEFAMILY:"V-type ATPases")) |
| pubmed:23091460 | bp(GO:autophagy) positiveCorrelation p(HGNC:PSEN1) |
| pubmed:22372633 | bp(GO:autophagy) negativeCorrelation bp(GO:"stress granule assembly") |
| pubmed:22372633 | bp(GO:autophagy) association p(HGNC:HDAC6) |
| pubmed:29661268 | bp(GO:autophagy) negativeCorrelation p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29661268 | bp(GO:autophagy) positiveCorrelation p(HGNC:ULK1) |
| pubmed:29661268 | bp(GO:autophagy) negativeCorrelation a(CHEBI:sirolimus) |
| pubmed:26968346 | bp(GO:autophagy) positiveCorrelation a(CHEBI:sirolimus) |
| pubmed:30061532 | bp(GO:autophagy) increases deg(p(MESH:Proteins, pmod(CONSO:misfolded))) |
| pubmed:21722302 | bp(GO:autophagy) decreases p(MESH:Proteins, pmod(CONSO:misfolded)) |
| pubmed:21722302 | bp(GO:autophagy) increases deg(p(MESH:Proteins, pmod(CONSO:misfolded))) |
| pubmed:30061532 | bp(GO:autophagy) decreases path(MESH:"Neurodegenerative Diseases") |
| pubmed:21722302 | bp(GO:autophagy) association path(MESH:"Neurodegenerative Diseases") |
| pubmed:18930136 | bp(GO:autophagy) association path(MESH:"Neurodegenerative Diseases") |
| pubmed:18930136 | bp(GO:autophagy) negativeCorrelation path(MESH:"Neurodegenerative Diseases") |
| pubmed:30061532 | bp(GO:autophagy) negativeCorrelation act(p(HGNC:MTOR)) |
| pubmed:30061532 | bp(GO:autophagy) regulates act(p(HGNC:MTOR)) |
| pubmed:30106381 | bp(GO:autophagy) association p(HGNC:MTOR) |
| pubmed:26968346 | bp(GO:autophagy) positiveCorrelation act(p(HGNC:MTOR)) |
| pubmed:29758300 | bp(GO:autophagy) negativeCorrelation p(HGNC:MTOR) |
| pubmed:18930136 | bp(GO:autophagy) negativeCorrelation p(HGNC:MTOR) |
| pubmed:30061532 | bp(GO:autophagy) decreases act(a(CHEBI:methamphetamine)) |
| pubmed:30061532 | bp(GO:autophagy) decreases act(a(CHEBI:methamphetamine)) |
| pubmed:30061532 | bp(GO:autophagy) decreases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30061532 | bp(GO:autophagy) decreases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30061532 | bp(GO:autophagy) association bp(GO:"dopamine secretion, neurotransmission") |
| pubmed:30061532 | bp(GO:autophagy) negativeCorrelation path(MESH:Schizophrenia) |
| pubmed:30061532 | bp(GO:autophagy) negativeCorrelation path(MESH:Schizophrenia) |
| pubmed:30061532 | bp(GO:autophagy) negativeCorrelation path(MESH:Schizophrenia) |
| pubmed:30061532 | bp(GO:autophagy) association p(HGNC:BECN1) |
| pubmed:26968346 | bp(GO:autophagy) positiveCorrelation p(HGNC:BECN1) |
| pubmed:26968346 | bp(GO:autophagy) positiveCorrelation act(p(HGNC:BECN1)) |
| pubmed:26702100 | bp(GO:autophagy) association p(HGNC:BECN1) |
| pubmed:30061532 | bp(GO:autophagy) association p(HGNC:ULK2) |
| pubmed:30061532 | bp(GO:autophagy) association p(HGNC:ATG3) |
| pubmed:30061532 | bp(GO:autophagy) negativeCorrelation path(MESH:Hallucinations) |
| pubmed:30106381 | bp(GO:autophagy) association p(HGNC:ADNP) |
| pubmed:30106381 | bp(GO:autophagy) association p(HGNC:ADNP) |
| pubmed:30106381 | bp(GO:autophagy) association a(PUBCHEM:9832404) |
| pubmed:22020111 | bp(GO:autophagy) positiveCorrelation complex(p(HGNC:BAG3), p(HGNC:HSPB8)) |
| pubmed:30688256 | bp(GO:autophagy) increases a(MESH:"Autophagy-Related Proteins", loc(GO:"phagophore assembly site")) |
| pubmed:30688256 | bp(GO:autophagy) association a(CHEBI:FAD) |
| pubmed:30012004 | bp(GO:autophagy) positiveCorrelation path(MESH:"Huntington Disease") |
| pubmed:30027901 | bp(GO:autophagy) association act(p(HGNC:HTT)) |
| pubmed:30027901 | bp(GO:autophagy) association p(HGNC:HTT) |
| pubmed:26968346 | bp(GO:autophagy) increases deg(p(HGNC:HTT)) |
| pubmed:30027901 | bp(GO:autophagy) decreases a(MESH:"Protein Aggregates") |
| pubmed:30027901 | bp(GO:autophagy) increases tloc(a(MESH:"Protein Aggregates"), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) |
| pubmed:23746257 | bp(GO:autophagy) decreases a(MESH:"Protein Aggregates") |
| pubmed:21722302 | bp(GO:autophagy) increases bp(MESH:Neuroprotection) |
| pubmed:21722302 | bp(GO:autophagy) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | bp(GO:autophagy) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | bp(GO:autophagy) association path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | bp(GO:autophagy) association path(MESH:"Alzheimer Disease") |
| pubmed:26968346 | bp(GO:autophagy) positiveCorrelation a(CHEBI:Temsirolimus) |
| pubmed:26968346 | bp(GO:autophagy) positiveCorrelation bp(GO:"regulation of ER to Golgi vesicle-mediated transport") |
| pubmed:26968346 | bp(GO:autophagy) negativeCorrelation p(CONSO:"alpha-synuclein aggregates") |
| pubmed:26968346 | bp(GO:autophagy) positiveCorrelation p(HGNC:RAB1A) |
| pubmed:27299292 | bp(GO:autophagy) positiveCorrelation act(p(HGNC:TFEB)) |
| pubmed:27299292 | bp(GO:autophagy) positiveCorrelation p(HGNC:TFEB) |
| pubmed:27299292 | bp(GO:autophagy) positiveCorrelation p(HGNC:AR, pmod(CONSO:"CAG repeats")) |
| pubmed:27299292 | bp(GO:autophagy) negativeCorrelation p(HGNC:AR, pmod(CONSO:"CAG repeats")) |
| pubmed:27299292 | bp(GO:autophagy) negativeCorrelation p(HGNC:AR, pmod(CONSO:"CAG repeats")) |
| pubmed:27299292 | bp(GO:autophagy) increases path(DOID:"pancreatic ductal adenocarcinoma") |
| pubmed:27299292 | bp(GO:autophagy) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pubmed:27299292 | bp(GO:autophagy) negativeCorrelation path(DOID:"spinal muscular atrophy") |
| pubmed:27299292 | bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) |
| pubmed:24844691 | bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) |
| pubmed:27299292 | bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(CONSO:misfolded))) |
| pubmed:29758300 | bp(GO:autophagy) positiveCorrelation bp(GO:"lysosomal protein catabolic process") |
| pubmed:22908190 | bp(GO:autophagy) positiveCorrelation bp(GO:"lysosomal protein catabolic process") |
| pubmed:29758300 | bp(GO:autophagy) decreases a(CHEBI:amyloid-beta) |
| pubmed:22908190 | bp(GO:autophagy) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:24844691 | bp(GO:autophagy) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29758300 | bp(GO:autophagy) increases deg(p(MESH:Proteins, pmod(CONSO:misfolding))) |
| pubmed:18930136 | bp(GO:autophagy) regulates deg(p(MESH:Proteins, pmod(CONSO:misfolding))) |
| pubmed:29758300 | bp(GO:autophagy) increases deg(a(CONSO:"protein aggregates")) |
| pubmed:22908190 | bp(GO:autophagy) increases deg(a(CONSO:"protein aggregates")) |
| pubmed:22908190 | bp(GO:autophagy) increases deg(a(CONSO:"protein aggregates")) |
| pubmed:22908190 | bp(GO:autophagy) increases deg(a(CONSO:"protein aggregates")) |
| pubmed:29758300 | bp(GO:autophagy) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29758300 | bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:29626319 | bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:29758300 | bp(GO:autophagy) association p(HGNC:MAPT, frag("?")) |
| pubmed:29758300 | bp(GO:autophagy) association a(CONSO:"Tau aggregates") |
| pubmed:29758300 | bp(GO:autophagy) increases deg(p(HGNC:SNCA)) |
| pubmed:18930136 | bp(GO:autophagy) increases deg(p(HGNC:SNCA)) |
| pubmed:30985105 | bp(GO:autophagy) increases act(p(HGNC:SNCA)) |
| pubmed:30985105 | bp(GO:autophagy) decreases p(HGNC:SNCA) |
| pubmed:29758300 | bp(GO:autophagy) decreases a(CHEBI:lipid) |
| pubmed:29758300 | bp(GO:autophagy) increases deg(a(CHEBI:lipid)) |
| pubmed:29758300 | bp(GO:autophagy) negativeCorrelation a(CHEBI:lipid) |
| pubmed:29758300 | bp(GO:autophagy) increases deg(a(CHEBI:carbohydrate)) |
| pubmed:29758300 | bp(GO:autophagy) increases deg(p(HGNC:MAPT)) |
| pubmed:30145931 | bp(GO:autophagy) decreases p(HGNC:MAPT) |
| pubmed:24027553 | bp(GO:autophagy) increases deg(p(HGNC:MAPT)) |
| pubmed:23528736 | bp(GO:autophagy) increases deg(p(HGNC:MAPT)) |
| pubmed:25374103 | bp(GO:autophagy) increases deg(p(HGNC:MAPT)) |
| pubmed:29626319 | bp(GO:autophagy) increases deg(p(HGNC:MAPT)) |
| pubmed:29626319 | bp(GO:autophagy) increases deg(p(HGNC:MAPT)) |
| pubmed:22908190 | bp(GO:autophagy) increases deg(a(GO:organelle)) |
| pubmed:22908190 | bp(GO:autophagy) increases deg(a(GO:organelle)) |
| pubmed:22908190 | bp(GO:autophagy) increases deg(a(GO:organelle)) |
| pubmed:18930136 | bp(GO:autophagy) increases tloc(a(GO:organelle), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) |
| pubmed:18930136 | bp(GO:autophagy) increases deg(a(GO:organelle)) |
| pubmed:18930136 | bp(GO:autophagy) increases deg(a(GO:organelle)) |
| pubmed:22908190 | bp(GO:autophagy) increases deg(a(MESH:"Inclusion Bodies")) |
| pubmed:22908190 | bp(GO:autophagy) negativeCorrelation bp(GO:"proteasomal protein catabolic process") |
| pubmed:22908190 | bp(GO:autophagy) increases deg(p(CONSO:"protein aggregates", pmod(go:0016567 ! "protein ubiquitination"))) |
| pubmed:22908190 | bp(GO:autophagy) increases rxn(reactants(p(HGNC:APP)), products(a(MESH:"Amyloid beta-Peptides"))) |
| pubmed:22908190 | bp(GO:autophagy) decreases path(MESH:Tauopathies) |
| pubmed:22908190 | bp(GO:autophagy) decreases path(CONSO:neurotoxicity) |
| pubmed:22908190 | bp(GO:autophagy) increases path(CONSO:neurotoxicity) |
| pubmed:30145931 | bp(GO:autophagy) decreases path(CONSO:neurotoxicity) |
| pubmed:22908190 | bp(GO:autophagy) association bp(GO:"regulation of synaptic plasticity") |
| pubmed:23746257 | bp(GO:autophagy) increases bp(GO:"protein catabolic process") |
| pubmed:26195256 | bp(GO:autophagy) increases bp(GO:"protein catabolic process") |
| pubmed:18930136 | bp(GO:autophagy) increases bp(GO:"cellular protein catabolic process") |
| pubmed:18930136 | bp(GO:autophagy) regulates bp(GO:"amino acid homeostasis") |
| pubmed:18930136 | bp(GO:autophagy) increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) |
| pubmed:18930136 | bp(GO:autophagy) increases deg(a(MESH:Proteins)) |
| pubmed:18930136 | bp(GO:autophagy) regulates bp(GO:"metabolic process") |
| pubmed:18930136 | bp(GO:autophagy) association bp(GO:"antigen processing and presentation") |
| pubmed:18930136 | bp(GO:autophagy) decreases bp(MESH:Microbiota) |
| pubmed:18930136 | bp(GO:autophagy) regulates bp(GO:"cell death") |
| pubmed:18930136 | bp(GO:autophagy) increases deg(p(HGNC:SNCA, var("?"))) |
| pubmed:18930136 | bp(GO:autophagy) increases deg(a(CONSO:"alpha-synuclein aggregates")) |
| pubmed:18930136 | bp(GO:autophagy) increases deg(a(CONSO:"alpha-synuclein oligomers")) |
| pubmed:18930136 | bp(GO:autophagy) regulates bp(GO:"neuron cellular homeostasis") |
| pubmed:18930136 | bp(GO:autophagy) decreases path(CONSO:Neurodegeneration) |
| pubmed:18930136 | bp(GO:autophagy) decreases path(CONSO:Neurodegeneration) |
| pubmed:18930136 | bp(GO:autophagy) negativeCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") |
| pubmed:18930136 | bp(GO:autophagy) increases deg(p(HGNC:APP)) |
| pubmed:18930136 | bp(GO:autophagy) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:18930136 | bp(GO:autophagy) negativeCorrelation act(complex(GO:"proteasome complex")) |
| pubmed:28803412 | bp(GO:autophagy) increases a(CONSO:CONSO00093) |
| pubmed:30145931 | bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356))) |
| pubmed:30116051 | bp(GO:autophagy) negativeCorrelation g(HGNC:PSEN1, var("?")) |
| pubmed:30116051 | bp(GO:autophagy) increases deg(p(HGNC:HTT, var("?"))) |
| pubmed:27181519 | bp(GO:autophagy) increases deg(p(HGNC:HTT, var("?"))) |
| pubmed:23528736 | bp(GO:autophagy) negativeCorrelation a(CHEBI:"reactive oxygen species") |
| pubmed:27181519 | bp(GO:autophagy) increases deg(complex(GO:"ribonucleoprotein granule")) |
| pubmed:27181519 | bp(GO:autophagy) association p(HGNC:SOD1, var("?")) |
| pubmed:27181519 | bp(GO:autophagy) isA bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") |
| pubmed:27181519 | bp(GO:autophagy) association a(CHEBI:"all-trans-retinoic acid") |
| pubmed:27181519 | bp(GO:autophagy) negativeCorrelation path(MESH:"Motor Neuron Disease") |
| pubmed:27181519 | bp(GO:autophagy) negativeCorrelation path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:27181519 | bp(GO:autophagy) negativeCorrelation path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:27181519 | bp(GO:autophagy) negativeCorrelation p(HGNC:FUS, var("?")) |
| pubmed:27181519 | bp(GO:autophagy) negativeCorrelation p(HGNC:TARDBP, var("?")) |
| pubmed:27181519 | bp(GO:autophagy) increases deg(p(HGNC:TARDBP, pmod(GO:"protein complex oligomerization"))) |
| pubmed:27181519 | bp(GO:autophagy) increases deg(p(HGNC:TARDBP, pmod(CONSO:"protein aggregation"))) |
| pubmed:27181519 | bp(GO:autophagy) increases deg(p(HGNC:TARDBP, pmod(CONSO:"protein aggregation"))) |
| pubmed:27181519 | bp(GO:autophagy) increases deg(p(HGNC:FUS, pmod(CONSO:"protein aggregation"))) |
| pubmed:27181519 | bp(GO:autophagy) association complex(p(HGNC:MAP1LC3A), p(HGNC:OPTN)) |
| pubmed:27181519 | bp(GO:autophagy) association a(CHEBI:"alpha,alpha-trehalose") |
| pubmed:27181519 | bp(GO:autophagy) association a(CHEBI:"lithium(1+)") |
| pubmed:27181519 | bp(GO:autophagy) association a(CHEBI:"withaferin A") |
| pubmed:26702100 | bp(GO:autophagy) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:26702100 | bp(GO:autophagy) association p(HGNC:ATG5) |
| pubmed:26702100 | bp(GO:autophagy) association p(HGNC:ATG9B) |
| pubmed:23702978 | bp(GO:autophagy) regulates bp(GO:"apoptotic process") |
| pubmed:23702978 | bp(GO:autophagy) regulates complex(GO:"inflammasome complex") |
| pubmed:23702978 | bp(GO:autophagy) decreases act(complex(GO:"inflammasome complex")) |
| pubmed:23702978 | bp(GO:autophagy) decreases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17361039 | r(HGNC:SLC1A3) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:17361039 | r(HGNC:SLC1A2) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:17361039 | p(HGNC:SLC1A2) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:17361039 | p(HGNC:SLC1A2) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:17361039 | r(HGNC:GRIK4) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:17361039 | p(HGNC:POLR2M) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:17361039 | p(HGNC:GRIA4) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24883238 | g(DBSNP:rs3764640) positiveCorrelation path(MESH:"Psychotic Disorders") |
| pubmed:24883238 | g(DBSNP:rs3764640) association p(HGNC:STK11) |
| pubmed:22005930 | g(DBSNP:rs3764640) association g(HGNC:STK11) |
| pubmed:24883238 | p(HGNC:STK11) association g(DBSNP:rs3764640) |
| pubmed:24883238 | p(HGNC:STK11) negativeCorrelation path(MESH:"Peutz-Jeghers Syndrome") |
| pubmed:24883238 | p(HGNC:STK11) negativeCorrelation path(MESH:"Intellectual Disability") |
| pubmed:24883238 | p(HGNC:STK11) negativeCorrelation path(MESH:Schizophrenia) |
| pubmed:24883238 | p(HGNC:STK11) association p(HGNC:APP) |
| pubmed:24883238 | p(HGNC:STK11) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:17950019 | p(HGNC:STK11) association p(HGNC:CRTC2) |
| pubmed:17950019 | p(HGNC:STK11) positiveCorrelation path(MESH:"Diabetes Mellitus, Type 2") |
| pubmed:23791179 | p(HGNC:STK11) positiveCorrelation bp(GO:"collateral sprouting") |
| pubmed:27462580 | p(HGNC:STK11) regulates bp(GO:"glucose import") |
| pubmed:27462580 | p(HGNC:STK11) increases a(MESH:"AMP-Activated Protein Kinases") |
| pubmed:16530014 | p(HGNC:STK11) negativeCorrelation tloc(a(CHEBI:glucose), fromLoc(MESH:Liver), toLoc(MESH:Blood)) |
| pubmed:16530014 | p(HGNC:STK11) negativeCorrelation a(CHEBI:glucose) |
| pubmed:16530014 | p(HGNC:STK11) negativeCorrelation path(MESH:Hyperglycemia) |
| pubmed:16530014 | p(HGNC:STK11) decreases act(a(CHEBI:metformin)) |
| pubmed:24883238 | path(MESH:"Peutz-Jeghers Syndrome") negativeCorrelation p(HGNC:STK11) |
| pubmed:24883238 | path(MESH:"Intellectual Disability") negativeCorrelation p(HGNC:STK11) |
| pubmed:27190210 | path(MESH:"Intellectual Disability") association g(HGNC:CHRNA7) |
| pubmed:24883238 | path(MESH:Schizophrenia) negativeCorrelation p(HGNC:STK11) |
| pubmed:22005930 | path(MESH:Schizophrenia) negativeCorrelation g(HGNC:STK11) |
| pubmed:30061532 | path(MESH:Schizophrenia) increases path(MESH:Hallucinations) |
| pubmed:24511233 | path(MESH:Schizophrenia) association path(MESH:Hallucinations) |
| pubmed:19721446 | path(MESH:Schizophrenia) association path(MESH:Hallucinations) |
| pubmed:30061532 | path(MESH:Schizophrenia) increases path(MESH:Delusions) |
| pubmed:24511233 | path(MESH:Schizophrenia) association path(MESH:Delusions) |
| pubmed:19721446 | path(MESH:Schizophrenia) association path(MESH:Delusions) |
| pubmed:30061532 | path(MESH:Schizophrenia) positiveCorrelation act(p(HGNC:DRD1)) |
| pubmed:30061532 | path(MESH:Schizophrenia) association g(HGNC:DISC1) |
| pubmed:30061532 | path(MESH:Schizophrenia) association g(HGNC:DISC1) |
| pubmed:30061532 | path(MESH:Schizophrenia) association g(HGNC:NRG1) |
| pubmed:30061532 | path(MESH:Schizophrenia) association g(HGNC:DPYSL2) |
| pubmed:30061532 | path(MESH:Schizophrenia) association g(HGNC:DPYSL2) |
| pubmed:30061532 | path(MESH:Schizophrenia) association path(MESH:"Psychotic Disorders") |
| pubmed:24511233 | path(MESH:Schizophrenia) association path(MESH:"Psychotic Disorders") |
| pubmed:30061532 | path(MESH:Schizophrenia) positiveCorrelation a(CHEBI:dopamine) |
| pubmed:30061532 | path(MESH:Schizophrenia) association tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30061532 | path(MESH:Schizophrenia) increases a(CHEBI:dopamine) |
| pubmed:30061532 | path(MESH:Schizophrenia) increases tloc(a(CHEBI:dopamine), fromLoc(MESH:"Nerve Endings"), toLoc(MESH:"Limbic System")) |
| pubmed:30061532 | path(MESH:Schizophrenia) decreases p(HGNC:SLC6A3) |
| pubmed:30061532 | path(MESH:Schizophrenia) negativeCorrelation p(HGNC:SLC18A2) |
| pubmed:30061532 | path(MESH:Schizophrenia) association a(CHEBI:"reactive oxygen species") |
| pubmed:30061532 | path(MESH:Schizophrenia) negativeCorrelation bp(GO:"cytoskeleton organization") |
| pubmed:30061532 | path(MESH:Schizophrenia) negativeCorrelation bp(GO:"neuron-neuron synaptic transmission") |
| pubmed:30061532 | path(MESH:Schizophrenia) decreases p(HGNC:MAP2) |
| pubmed:30061532 | path(MESH:Schizophrenia) decreases a(GO:dendrite) |
| pubmed:30061532 | path(MESH:Schizophrenia) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:30061532 | path(MESH:Schizophrenia) increases p(HGNC:MAPT, loc(MESH:Neurons)) |
| pubmed:30061532 | path(MESH:Schizophrenia) decreases bp(GO:"oligodendrocyte development") |
| pubmed:30061532 | path(MESH:Schizophrenia) association path(MESH:Catatonia) |
| pubmed:30061532 | path(MESH:Schizophrenia) association p(HGNC:DISC1) |
| pubmed:30061532 | path(MESH:Schizophrenia) association p(HGNC:DISC1) |
| pubmed:30061532 | path(MESH:Schizophrenia) association p(HGNC:DTNBP1) |
| pubmed:30061532 | path(MESH:Schizophrenia) association p(HGNC:DTNBP1) |
| pubmed:30061532 | path(MESH:Schizophrenia) association p(HGNC:DPYSL2) |
| pubmed:30562574 | path(MESH:Schizophrenia) association p(HGNC:DPYSL2) |
| pubmed:30061532 | path(MESH:Schizophrenia) negativeCorrelation act(a(GO:microtubule)) |
| pubmed:30061532 | path(MESH:Schizophrenia) association bp(GO:"protein kinase B signaling") |
| pubmed:30061532 | path(MESH:Schizophrenia) decreases bp(GO:"protein kinase B signaling") |
| pubmed:30061532 | path(MESH:Schizophrenia) association bp(GO:"protein kinase B signaling") |
| pubmed:30061532 | path(MESH:Schizophrenia) decreases p(FPLX:AKT) |
| pubmed:30061532 | path(MESH:Schizophrenia) association p(HGNC:NRG1) |
| pubmed:30061532 | path(MESH:Schizophrenia) association p(HGNC:NRG1) |
| pubmed:30061532 | path(MESH:Schizophrenia) association p(HGNC:ERBB4) |
| pubmed:30061532 | path(MESH:Schizophrenia) association act(p(HGNC:MTOR)) |
| pubmed:30061532 | path(MESH:Schizophrenia) negativeCorrelation act(p(HGNC:MTOR)) |
| pubmed:30061532 | path(MESH:Schizophrenia) negativeCorrelation p(HGNC:CDK5R1) |
| pubmed:30061532 | path(MESH:Schizophrenia) positiveCorrelation act(p(HGNC:CDK5)) |
| pubmed:30061532 | path(MESH:Schizophrenia) association p(HGNC:ULK1, var("?")) |
| pubmed:30061532 | path(MESH:Schizophrenia) negativeCorrelation bp(GO:autophagy) |
| pubmed:30061532 | path(MESH:Schizophrenia) negativeCorrelation bp(GO:autophagy) |
| pubmed:30061532 | path(MESH:Schizophrenia) negativeCorrelation bp(GO:autophagy) |
| pubmed:30061532 | path(MESH:Schizophrenia) decreases p(HGNC:BECN1) |
| pubmed:30061532 | path(MESH:Schizophrenia) decreases p(HGNC:BECN1) |
| pubmed:30061532 | path(MESH:Schizophrenia) decreases p(HGNC:ULK2) |
| pubmed:30061532 | path(MESH:Schizophrenia) decreases p(HGNC:ATG3) |
| pubmed:30061532 | path(MESH:Schizophrenia) decreases r(HGNC:BECN1) |
| pubmed:30061532 | path(MESH:Schizophrenia) decreases p(HGNC:ADNP) |
| pubmed:30061532 | path(MESH:Schizophrenia) decreases p(HGNC:ADNP2) |
| pubmed:19126755 | path(MESH:Schizophrenia) negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19126755 | path(MESH:Schizophrenia) association path(MESH:"Sensory Gating") |
| pubmed:19126755 | path(MESH:Schizophrenia) association path(MESH:"Sensory Gating") |
| pubmed:24511233 | path(MESH:Schizophrenia) association path(MESH:"Cognitive Dysfunction") |
| pubmed:24511233 | path(MESH:Schizophrenia) association bp(GO:cognition) |
| pubmed:19721446 | path(MESH:Schizophrenia) association bp(GO:cognition) |
| pubmed:24511233 | path(MESH:Schizophrenia) association bp(GO:behavior) |
| pubmed:24511233 | path(MESH:Schizophrenia) decreases bp(GO:"synaptic transmission, cholinergic") |
| pubmed:24511233 | path(MESH:Schizophrenia) association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:24511233 | path(MESH:Schizophrenia) association path(MESH:"Memory, Short-Term") |
| pubmed:24511233 | path(MESH:Schizophrenia) association path(MESH:Attention) |
| pubmed:24511233 | path(MESH:Schizophrenia) association path(MESH:"Executive Function") |
| pubmed:24511233 | path(MESH:Schizophrenia) association bp(GO:"synaptic transmission, glutamatergic") |
| pubmed:24511233 | path(MESH:Schizophrenia) association bp(GO:"gamma-aminobutyric acid signaling pathway") |
| pubmed:17009926 | path(MESH:Schizophrenia) association p(FPLX:CHRN) |
| pubmed:17009926 | path(MESH:Schizophrenia) association p(FPLX:CHRN) |
| pubmed:21482353 | path(MESH:Schizophrenia) association act(p(FPLX:CHRN)) |
| pubmed:11230871 | path(MESH:Schizophrenia) association p(FPLX:CHRN) |
| pubmed:21482353 | path(MESH:Schizophrenia) positiveCorrelation p(HGNC:CHRNA7, var("?")) |
| pubmed:21482353 | path(MESH:Schizophrenia) association bp(GO:"GABAergic neuron differentiation") |
| pubmed:21482353 | path(MESH:Schizophrenia) increases act(a(MESH:Hippocampus)) |
| pubmed:21482353 | path(MESH:Schizophrenia) association g(HGNC:CHRFAM7A, var("?")) |
| pubmed:21482353 | path(MESH:Schizophrenia) association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pubmed:21482353 | path(MESH:Schizophrenia) positiveCorrelation path(MESH:"Tobacco Use Disorder") |
| pubmed:21482353 | path(MESH:Schizophrenia) association p(HGNC:PEMT, var("?")) |
| pubmed:11230871 | path(MESH:Schizophrenia) negativeCorrelation complex(CONSO:"alpha-7-containing nAChR") |
| pubmed:11230871 | path(MESH:Schizophrenia) causesNoChange complex(CONSO:"alpha-4-containing nAChR") |
| pubmed:19721446 | path(MESH:Schizophrenia) association bp(MESH:"Sensory Gating") |
| pubmed:19721446 | path(MESH:Schizophrenia) decreases p(HGNC:CHRNA7) |
| pubmed:22040696 | path(MESH:Schizophrenia) negativeCorrelation p(HGNC:CHRNA7) |
| pubmed:22040696 | path(MESH:Schizophrenia) positiveCorrelation r(HGNC:RIC3) |
| pubmed:17950019 | p(HGNC:CRTC2) association p(HGNC:STK11) |
| pubmed:17950019 | p(HGNC:CRTC2) positiveCorrelation path(MESH:"Diabetes Mellitus, Type 2") |
| pubmed:17950019 | path(MESH:"Diabetes Mellitus, Type 2") positiveCorrelation p(HGNC:STK11) |
| pubmed:17950019 | path(MESH:"Diabetes Mellitus, Type 2") positiveCorrelation p(HGNC:CRTC2) |
| pubmed:22236693 | path(MESH:"Diabetes Mellitus, Type 2") association g(RGD:Ngfr) |
| pubmed:22107728 | path(MESH:"Diabetes Mellitus, Type 2") association g(DBSNP:rs2251101) |
| pubmed:23279143 | path(MESH:"Diabetes Mellitus, Type 2") association p(HGNC:SORCS1) |
| pubmed:23279143 | path(MESH:"Diabetes Mellitus, Type 2") association g(DBSNP:rs7907690) |
| pubmed:19732809 | path(MESH:"Diabetes Mellitus, Type 2") negativeCorrelation p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:23791179 | bp(GO:"collateral sprouting") positiveCorrelation p(HGNC:STK11) |
| pubmed:23791179 | bp(GO:"collateral sprouting") positiveCorrelation p(HGNC:NUAK1) |
| pubmed:23791179 | p(HGNC:NUAK1) positiveCorrelation bp(GO:"collateral sprouting") |
| pubmed:21861815 | bp(GO:"glucose import") negativeCorrelation path(DOID:"Alzheimer's disease") |
| pubmed:22005930 | g(HGNC:STK11) negativeCorrelation path(MESH:Schizophrenia) |
| pubmed:22005930 | g(HGNC:STK11) association g(DBSNP:rs3764640) |
| pubmed:22005930 | g(HGNC:STK11) association path(MESH:"Alzheimer Disease") |
| pubmed:16530014 | tloc(a(CHEBI:glucose), fromLoc(MESH:Liver), toLoc(MESH:Blood)) negativeCorrelation p(HGNC:STK11) |
| pubmed:16530014 | a(CHEBI:glucose) negativeCorrelation p(HGNC:STK11) |
| pubmed:30985105 | a(CHEBI:glucose) positiveCorrelation p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:16530014 | path(MESH:Hyperglycemia) negativeCorrelation p(HGNC:STK11) |
| pubmed:30985105 | path(MESH:Hyperglycemia) increases p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:16530014 | a(CHEBI:metformin) decreases a(CHEBI:glucose) |
| pubmed:30116051 | a(CHEBI:metformin) increases act(p(FPLX:AMPK)) |
| pubmed:30116051 | a(CHEBI:metformin) increases bp(GO:macroautophagy) |
| pubmed:30116051 | a(CHEBI:metformin) increases bp(MESH:Longevity) |
| pubmed:30116051 | a(CHEBI:metformin) decreases a(CHEBI:amyloid-beta) |
| pubmed:30116051 | a(CHEBI:metformin) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:30116051 | a(CHEBI:metformin) decreases bp(GO:"neuron death") |
| pubmed:17234589 | bp(MESH:"Osmolar Concentration") association p(FB:Lkb1) |
| pubmed:17234589 | bp(MESH:"Osmolar Concentration") increases p(FB:tau, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:14556719 | bp(MESH:"Osmolar Concentration") positiveCorrelation bp(GO:"response to unfolded protein") |
| pubmed:17234589 | p(FB:Lkb1) association bp(MESH:"Osmolar Concentration") |
| pubmed:17234589 | p(FB:Lkb1) association p(HGNC:APP) |
| pubmed:17234589 | p(FB:Lkb1) increases p(INTERPRO:"Serine/threonine-protein kinase MARK/par1", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:17234589 | p(INTERPRO:"Serine/threonine-protein kinase MARK/par1", pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation act(p(INTERPRO:"Serine/threonine-protein kinase MARK/par1")) |
| pubmed:25932647 | p(INTERPRO:"Serine/threonine-protein kinase MARK/par1", pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation act(p(INTERPRO:"Serine/threonine-protein kinase MARK/par1")) |
| pubmed:17234589 | act(p(INTERPRO:"Serine/threonine-protein kinase MARK/par1")) positiveCorrelation p(INTERPRO:"Serine/threonine-protein kinase MARK/par1", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25932647 | act(p(INTERPRO:"Serine/threonine-protein kinase MARK/par1")) positiveCorrelation p(INTERPRO:"Serine/threonine-protein kinase MARK/par1", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:17234589 | act(p(INTERPRO:"Serine/threonine-protein kinase MARK/par1")) increases p(FB:tau, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25932647 | p(INTERPRO:"Serine/threonine-protein kinase MARK/par1") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25932647 | p(INTERPRO:"Serine/threonine-protein kinase MARK/par1") negativeCorrelation path(MESH:"Autistic Disorder") |
| pubmed:25932647 | p(INTERPRO:"Serine/threonine-protein kinase MARK/par1") negativeCorrelation path(MESH:Neoplasms) |
| pubmed:25932647 | path(MESH:"Autistic Disorder") negativeCorrelation p(INTERPRO:"Serine/threonine-protein kinase MARK/par1") |
| pubmed:17009926 | path(MESH:"Autistic Disorder") association p(FPLX:CHRN) |
| pubmed:17009926 | path(MESH:"Autistic Disorder") negativeCorrelation act(p(FPLX:CHRN)) |
| pubmed:17009926 | path(MESH:"Autistic Disorder") negativeCorrelation p(FPLX:CHRN) |
| pubmed:30106381 | path(MESH:"Autistic Disorder") association p(HGNC:ADNP) |
| pubmed:30106381 | path(MESH:"Autistic Disorder") association a(PUBCHEM:9832404) |
| pubmed:25932647 | path(MESH:Neoplasms) negativeCorrelation p(INTERPRO:"Serine/threonine-protein kinase MARK/par1") |
| pubmed:19126755 | path(MESH:Neoplasms) association path(MESH:"Tobacco Use Disorder") |
| pubmed:28901280 | path(MESH:Neoplasms) association p(HGNC:CHRNA7) |
| pubmed:22020111 | path(MESH:Neoplasms) negativeCorrelation p(HGNC:AIFM2) |
| pubmed:22020111 | path(MESH:Neoplasms) negativeCorrelation p(HGNC:GPX3) |
| pubmed:23454242 | path(MESH:Neoplasms) association p(FPLX:PPP2) |
| pubmed:23454242 | path(MESH:Neoplasms) negativeCorrelation act(p(FPLX:PPP2)) |
| pubmed:22299660 | path(MESH:Neoplasms) association p(FPLX:PPP2) |
| pubmed:30740335 | path(MESH:Neoplasms) association path(MESH:"Endoplasmic Reticulum Stress") |
| pubmed:25784053 | path(MESH:Neoplasms) association act(p(HGNC:HSF1)) |
| pubmed:18930136 | path(MESH:Neoplasms) negativeCorrelation bp(GO:"cellular protein catabolic process") |
| pubmed:24563850 | path(MESH:Neoplasms) increases p(HGNCGENEFAMILY:"Small heat shock proteins") |
| pubmed:24563850 | path(MESH:Neoplasms) association bp(GO:"protein oxidation") |
| pubmed:29311797 | path(MESH:Neoplasms) association p(HGNC:STUB1) |
| pubmed:25932647 | p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") increases p(INTERPRO:"Serine/threonine-protein kinase MARK/par1") |
| pubmed:25932647 | p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") association p(RGD:Prkaca) |
| pubmed:19419557 | act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) association complex(a(CONSO:"amyloid-beta oligomers"), p(HGNC:GRIN1)) |
| pubmed:21871088 | act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) increases bp(GO:"calcium ion import") |
| pubmed:20556492 | act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) increases bp(GO:"calcium ion import") |
| pubmed:19126755 | act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) increases a(CHEBI:anandamide) |
| pubmed:24511233 | p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") regulates bp(MESH:"Neuronal Plasticity") |
| pubmed:24511233 | p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") association bp(GO:cognition) |
| pubmed:22530628 | p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") increases act(a(CHEBI:"glutamate(2-)")) |
| pubmed:22530628 | p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") increases p(HGNC:ARC) |
| pubmed:16273023 | act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) decreases bp(MESH:D017774) |
| pubmed:20556492 | act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) association bp(GO:"calcium ion homeostasis") |
| pubmed:20556492 | tloc(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits"), fromLoc(GO:cytoplasm), toLoc(GO:"plasma membrane")) increases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pubmed:20556492 | act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) increases path(MP:0008235) |
| pubmed:30988501 | p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") positiveCorrelation path(DOID:schizophrenia) |
| pubmed:25932647 | p(RGD:Prkaca) association p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") |
| pubmed:25932647 | p(RGD:Prkaca) increases p(RGD:Stk11, pmod(go:0006468 ! "protein phosphorylation", Ser, 431)) |
| pubmed:25932647 | p(RGD:Stk11) increases p(INTERPRO:"Serine/threonine-protein kinase MARK/par1", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:31346362 | path(DOID:amyloidosis) increases p(CONSO:"Tau aggregates", loc(GO:cytosol)) |
| pubmed:31346362 | path(DOID:amyloidosis) increases p(CONSO:"huntingtin aggregates", loc(GO:nucleus)) |
| pubmed:31346362 | path(DOID:amyloidosis) increases p(CONSO:"amyloid-beta fibrils", loc(GO:"endoplasmic reticulum")) |
| pubmed:31346362 | path(DOID:amyloidosis) increases tloc(p(CONSO:"amyloid-beta fibrils"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:31346362 | path(DOID:amyloidosis) increases p(CONSO:"amyloid-beta fibrils", loc(GO:"extracellular space")) |
| pubmed:31346362 | path(DOID:amyloidosis) increases p(CONSO:"amyloid-beta fibrils", loc(MESH:Plasma)) |
| pubmed:31346362 | path(DOID:amyloidosis) increases p(NCIT:C16720) |
| pubmed:31346362 | path(DOID:amyloidosis) increases p(NCIT:C16720, frag("?")) |
| pubmed:31346362 | path(DOID:amyloidosis) increases p(HGNC:SAA1) |
| pubmed:31346362 | path(DOID:amyloidosis) increases p(HGNC:TTR) |
| pubmed:31346362 | path(DOID:amyloidosis) increases p(HGNC:FGA) |
| pubmed:31346362 | path(DOID:amyloidosis) increases p(HGNC:B2M) |
| pubmed:31346362 | path(DOID:amyloidosis) increases p(HGNC:LYZ) |
| pubmed:31346362 | path(DOID:amyloidosis) increases p(HGNC:GSN) |
| pubmed:31346362 | path(DOID:amyloidosis) increases a(MESH:Lipofuscin) |
| pubmed:21156028 | path(DOID:amyloidosis) increases bp(GO:"neuron death") |
| pubmed:28760828 | p(CONSO:"Tau aggregates") association act(p(HGNC:EP300)) |
| pubmed:28760828 | p(CONSO:"Tau aggregates") association act(p(HGNC:HDAC6)) |
| pubmed:28760828 | p(CONSO:"Tau aggregates") association p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:28760828 | p(CONSO:"Tau aggregates") negativeCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 259), pmod(go:0006473 ! "protein acetylation", Gln, 290), pmod(go:0006473 ! "protein acetylation", Gln, 321), pmod(go:0006473 ! "protein acetylation", Gln, 353), var("p.Lys259Gln"), var("p.Lys290Gln"), var("p.Lys321Gln"), var("p.Lys352Gln")) |
| pubmed:25031639 | p(CONSO:"Tau aggregates", loc(GO:cytosol)) increases p(MESH:"Neurofibrillary Tangles") |
| pubmed:25031639 | p(CONSO:"Tau aggregates", loc(GO:cytosol)) increases p(CONSO:"paired helical filaments") |
| pubmed:25031639 | p(CONSO:"Tau aggregates") negativeCorrelation bp(GO:"axonal transport") |
| pubmed:25031639 | p(CONSO:"Tau aggregates") negativeCorrelation bp(GO:"synaptic signaling") |
| pubmed:29844403 | p(CONSO:"Tau aggregates") increases path(HP:"Abnormal synaptic transmission") |
| pubmed:29661268 | p(CONSO:"Tau aggregates") negativeCorrelation p(HGNC:STUB1) |
| pubmed:29661268 | p(CONSO:"Tau aggregates") negativeCorrelation p(HGNCGENEFAMILY:"Heat shock 70kDa proteins") |
| pubmed:29661268 | p(CONSO:"Tau aggregates") decreases act(p(MESH:"Proteasome Endopeptidase Complex")) |
| pubmed:26751493 | p(CONSO:"Tau aggregates") association a(CHEBI:heparin) |
| pubmed:26751493 | p(CONSO:"Tau aggregates") increases complex(a(CHEBI:heparin), p(CONSO:"Tau aggregates")) |
| pubmed:26751493 | p(CONSO:"Tau aggregates") partOf complex(a(CHEBI:heparin), p(CONSO:"Tau aggregates")) |
| pubmed:26195256 | p(CONSO:"Tau aggregates") association path(MESH:"Brain Injuries, Traumatic") |
| pubmed:26195256 | p(CONSO:"Tau aggregates") increases path(MESH:"Neurodegenerative Diseases") |
| pubmed:24869773 | p(CONSO:"Tau aggregates") association p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 311)) |
| pubmed:19517062 | p(CONSO:"Tau aggregates") increases bp(GO:"apoptotic process") |
| pubmed:19517062 | p(CONSO:"Tau aggregates") increases bp(GO:"necrotic cell death") |
| pubmed:26751493 | p(CONSO:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) |
| pubmed:24033439 | p(CONSO:"Tau aggregates") increases a(GO:"neurofibrillary tangle") |
| pubmed:28500862 | p(CONSO:"Tau aggregates") positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:27299292 | p(CONSO:"huntingtin aggregates") positiveCorrelation path(DOID:"Huntington's disease") |
| pubmed:31346362 | p(CONSO:"amyloid-beta fibrils", loc(GO:intracellular)) increases bp(GO:"cellular respiration") |
| pubmed:31346362 | p(CONSO:"amyloid-beta fibrils", loc(GO:intracellular)) increases bp(GO:"reactive oxygen species biosynthetic process") |
| pubmed:31346362 | p(CONSO:"amyloid-beta fibrils", loc(GO:intracellular)) increases bp(GO:"cell death") |
| pubmed:31346362 | p(CONSO:"amyloid-beta fibrils") increases a(MESH:Alarmins) |
| pubmed:27209302 | p(CONSO:"amyloid-beta fibrils", loc(MESH:Lysosomes)) increases deg(p(CONSO:"amyloid-beta fibrils")) |
| pubmed:27209302 | deg(p(CONSO:"amyloid-beta fibrils")) association a(CHEBI:phosphoramidon) |
| pubmed:27209302 | act(p(CONSO:"amyloid-beta fibrils")) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:27209302 | act(p(CONSO:"amyloid-beta fibrils")) causesNoChange act(p(HGNCGENEFAMILY:"MTOR complex 1")) |
| pubmed:27209302 | act(p(CONSO:"amyloid-beta fibrils")) decreases p(HGNCGENEFAMILY:"MTOR complex 1", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:31346362 | p(HGNCGENEFAMILY:Aminopeptidases) decreases p(CONSO:"amyloid-beta fibrils") |
| pubmed:24027553 | act(p(HGNCGENEFAMILY:Aminopeptidases)) increases deg(p(HGNC:MAPT)) |
| pubmed:31346362 | p(CONSO:"amyloid-beta aggregates") increases path(DOID:amyloidosis) |
| pubmed:31346362 | p(CONSO:"amyloid-beta aggregates") increases bp(MESH:"Cell Hypoxia") |
| pubmed:31346362 | p(CONSO:"amyloid-beta aggregates") increases act(p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) |
| pubmed:31346362 | p(CONSO:"amyloid-beta aggregates", loc(GO:intracellular)) increases bp(GO:autophagy) |
| pubmed:31346362 | p(CONSO:"amyloid-beta aggregates", loc(GO:intracellular)) increases a(MESH:Lipofuscin) |
| pubmed:31346362 | p(CONSO:"amyloid-beta aggregates") increases path(EFO:hypoxia) |
| pubmed:31346362 | p(CONSO:"amyloid-beta aggregates") increases path(NCIT:C82901) |
| pubmed:23516100 | bp(GO:"cell death") association p(MESH:Proteins, frag("?")) |
| pubmed:14556719 | bp(GO:"cell death") positiveCorrelation p(HGNC:GPR37) |
| pubmed:23746257 | bp(GO:"cell death") negativeCorrelation bp(CONSO:Proteostasis) |
| pubmed:18930136 | bp(GO:"cell death") negativeCorrelation a(GO:aggresome) |
| pubmed:18305152 | bp(GO:"cell death") negativeCorrelation p(HGNC:TARDBP) |
| pubmed:27181519 | bp(GO:"cell death") association p(CONSO:"protein aggregates") |
| pubmed:28669544 | bp(GO:"cell death") increases path(MESH:Neuropathology) |
| pubmed:24561250 | bp(GO:"cell death") increases tloc(a(CHEBI:ATP), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:31346362 | complex(p(CONSO:"amyloid-beta aggregates"), p(HGNCGENEFAMILY:"Long pentraxins")) decreases bp(GO:proteolysis) |
| pubmed:31346362 | complex(p(CONSO:"amyloid-beta aggregates"), p(HGNCGENEFAMILY:"Long pentraxins")) increases bp(GO:"macrophage activation") |
| pubmed:29758300 | bp(GO:proteolysis) decreases bp(GO:"neuron death") |
| pubmed:14556719 | bp(GO:proteolysis) association p(HGNC:UBA3) |
| pubmed:24027553 | bp(GO:proteolysis) increases bp(GO:autophagy) |
| pubmed:24027553 | bp(GO:proteolysis) decreases a(MESH:Autophagosomes) |
| pubmed:29626319 | bp(GO:proteolysis) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:31346362 | bp(GO:"macrophage activation") increases bp(GO:phagocytosis) |
| pubmed:26445701 | bp(GO:"macrophage activation") increases path(HP:"CNS demyelination") |
| pubmed:26445701 | bp(GO:"macrophage activation") increases path(MESH:"Diffuse Axonal Injury") |
| pubmed:26445701 | bp(GO:"macrophage activation") increases bp(GO:"positive regulation of oligodendrocyte apoptotic process") |
| pubmed:30967783 | bp(GO:"macrophage activation") increases tloc(a(MESH:Chemokines), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30967783 | bp(GO:"macrophage activation") increases tloc(a(MESH:Cytokines), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30967783 | bp(GO:"macrophage activation") increases path(DOID:"multiple sclerosis") |
| pubmed:30967783 | bp(GO:"macrophage activation") increases a(CHEBI:"prostaglandin E2") |
| pubmed:30967783 | bp(GO:"macrophage activation") association a(DRUGBANK:"Ethyl pyruvate") |
| pubmed:30967783 | bp(GO:"macrophage activation") association a(CHEBI:spermidine) |
| pubmed:30967783 | bp(GO:"macrophage activation") association a(CHEBI:"bryostatin 1") |
| pubmed:30967783 | bp(GO:"macrophage activation") association a(CHEBI:forskolin) |
| pubmed:30967783 | bp(GO:"macrophage activation") association a(DRUGBANK:Lenalidomide) |
| pubmed:21482353 | bp(GO:"macrophage activation") association p(CONSO:"alpha-7-containing nAChR") |
| pubmed:31413141 | bp(GO:"macrophage activation") increases p(HGNC:TREM2) |
| pubmed:31413141 | bp(GO:"macrophage activation") increases p(HGNC:MS4A4A) |
| pubmed:31413141 | bp(GO:"macrophage activation") increases p(HGNC:TREM2, frag("?")) |
| pubmed:31346362 | bp(MESH:"Cell Hypoxia") increases act(p(HGNC:HIF1A)) |
| pubmed:31346362 | p(HGNC:HIF1A) increases bp(GO:"inflammatory response") |
| pubmed:31346362 | p(HGNC:HIF1A) increases bp(GO:"inflammatory response") |
| pubmed:31346362 | p(HGNC:HIF1A) increases bp(GO:"cell death") |
| pubmed:31346362 | p(HGNC:HIF1A) increases g(HGNC:VEGFA) |
| pubmed:31346362 | p(HGNC:HIF1A) increases bp(GO:angiogenesis) |
| pubmed:31346362 | p(HGNC:HIF1A) increases g(HGNC:SLC2A1) |
| pubmed:31346362 | p(HGNC:HIF1A) increases g(HGNC:HK2) |
| pubmed:31346362 | p(HGNC:HIF1A) increases bp(GO:"glycolytic process") |
| pubmed:21861815 | p(HGNC:HIF1A) increases bp(GO:"glycolytic process") |
| pubmed:31346362 | p(HGNC:HIF1A) increases g(HGNCGENEFAMILY:"Toll like receptors") |
| pubmed:31346362 | p(HGNC:HIF1A) increases a(MESH:Alarmins) |
| pubmed:31346362 | p(HGNC:HIF1A) increases a(MESH:Cytokines) |
| pubmed:31346362 | p(HGNC:HIF1A) increases p(MESH:"Matrix Metalloproteinases") |
| pubmed:31346362 | p(HGNC:HIF1A) increases bp(GO:autophagy) |
| pubmed:31346362 | p(HGNC:HIF1A) increases g(HGNC:TERT) |
| pubmed:31346362 | p(HGNC:HIF1A) increases g(HGNC:TGFB1) |
| pubmed:31346362 | p(HGNC:HIF1A) increases p(CONSO:"amyloid-beta fibrils") |
| pubmed:21861815 | p(HGNC:HIF1A) regulates act(p(MESH:"Hypoxia-Inducible Factor 1")) |
| pubmed:21861815 | p(HGNC:HIF1A, loc(GO:nucleus)) increases complex(p(HGNC:ARNT), p(HGNC:HIF1A), loc(GO:nucleus)) |
| pubmed:21861815 | p(HGNC:HIF1A) increases bp(GO:"pentose-phosphate shunt") |
| pubmed:21861815 | p(HGNC:HIF1A) increases p(HGNC:SLC2A1) |
| pubmed:21861815 | p(HGNC:HIF1A) increases p(HGNC:SLC2A3) |
| pubmed:21861815 | p(HGNC:HIF1A) decreases path(DOID:"Alzheimer's disease") |
| pubmed:21861815 | p(HGNC:HIF1A) increases r(HGNC:TH) |
| pubmed:31346362 | p(HGNCGENEFAMILY:"NF-kappa B complex subunits") increases bp(GO:"inflammatory response") |
| pubmed:31346362 | act(p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) increases bp(GO:"inflammatory response") |
| pubmed:30027901 | p(HGNCGENEFAMILY:"NF-kappa B complex subunits") regulates bp(GO:"inflammatory response") |
| pubmed:31346362 | p(HGNCGENEFAMILY:"NF-kappa B complex subunits") increases bp(GO:"cell death") |
| pubmed:31346362 | act(p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) increases bp(GO:"cellular respiration") |
| pubmed:31346362 | act(p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) increases bp(GO:"programmed cell death") |
| pubmed:31346362 | act(p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) increases bp(GO:phagocytosis) |
| pubmed:31346362 | act(p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) increases a(CHEBI:"reactive oxygen species") |
| pubmed:30027901 | p(HGNCGENEFAMILY:"NF-kappa B complex subunits") association path(MESH:"Huntington Disease") |
| pubmed:31346362 | a(CHEBI:dioxygen) increases bp(GO:"ATP biosynthetic process") |
| pubmed:31346362 | a(CHEBI:dioxygen) increases bp(GO:"energy homeostasis") |
| pubmed:31346362 | a(CHEBI:dioxygen) increases bp(GO:"establishment or maintenance of transmembrane electrochemical gradient") |
| pubmed:31346362 | a(CHEBI:dioxygen) regulates bp(GO:"cellular calcium ion homeostasis") |
| pubmed:30515821 | bp(GO:"ATP biosynthetic process") negativeCorrelation act(p(HGNC:DNM1L)) |
| pubmed:30837838 | bp(GO:"ATP biosynthetic process") association bp(GO:"neuron fate commitment") |
| pubmed:30837838 | bp(GO:"ATP biosynthetic process") association path(MESH:"Nerve Degeneration") |
| pubmed:30515821 | bp(GO:"energy homeostasis") decreases path(DOID:"neurodegenerative disease") |
| pubmed:19126755 | bp(GO:"energy homeostasis") regulates a(CHEBI:"kynurenic acid") |
| pubmed:30027901 | bp(GO:"energy homeostasis") decreases tloc(a(CHEBI:"D-glutamate residue"), fromLoc(GO:cytoplasm), toLoc(GO:"extracellular space")) |
| pubmed:30027901 | bp(GO:"energy homeostasis") decreases path(CONSO:Excitotoxicity) |
| pubmed:21861815 | bp(GO:"energy homeostasis") negativeCorrelation path(DOID:hypoglycemia) |
| pubmed:21861815 | bp(GO:"energy homeostasis") negativeCorrelation path(EFO:hypoxia) |
| pubmed:21861815 | bp(GO:"energy homeostasis") decreases bp(GO:"neuron death") |
| pubmed:21871088 | bp(GO:"cellular calcium ion homeostasis") association bp(GO:"long-term synaptic depression") |
| pubmed:21871088 | bp(GO:"cellular calcium ion homeostasis") association bp(GO:"long-term synaptic potentiation") |
| pubmed:31346362 | bp(GO:"membrane lipid catabolic process") increases deg(a(MESH:Cytoskeleton)) |
| pubmed:23454242 | a(MESH:Cytoskeleton) association p(HGNC:PPP2R2C) |
| pubmed:22299660 | a(MESH:Cytoskeleton) association p(FPLX:PPP2) |
| pubmed:31346362 | act(p(HGNCGENEFAMILY:Calpains)) increases bp(GO:"cell death") |
| pubmed:27889190 | act(p(HGNCGENEFAMILY:Calpains)) decreases a(GO:cytoskeleton) |
| pubmed:29428175 | p(HGNCGENEFAMILY:Calpains) increases p(GO:spectrin) |
| pubmed:23516100 | act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:HTT, frag("?")) |
| pubmed:23516100 | act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:HTT, frag("?")) |
| pubmed:23516100 | p(HGNCGENEFAMILY:Calpains) regulates bp(GO:"calcium ion homeostasis") |
| pubmed:23516100 | p(HGNCGENEFAMILY:Calpains) regulates bp(GO:"regulation of synaptic plasticity") |
| pubmed:23516100 | p(HGNCGENEFAMILY:Calpains) regulates bp(GO:"programmed cell death") |
| pubmed:23516100 | p(HGNCGENEFAMILY:Calpains) regulates bp(GO:"nervous system development") |
| pubmed:23516100 | act(p(HGNCGENEFAMILY:Calpains)) negativeCorrelation bp(GO:"cytoskeleton organization") |
| pubmed:23516100 | act(p(HGNCGENEFAMILY:Calpains)) positiveCorrelation path(DOID:"Alzheimer's disease") |
| pubmed:23516100 | act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("1_?")) |
| pubmed:23516100 | act(p(HGNCGENEFAMILY:Calpains)) causesNoChange p(CONSO:"paired helical filaments") |
| pubmed:23516100 | act(p(HGNCGENEFAMILY:Calpains)) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23516100 | act(p(HGNCGENEFAMILY:Calpains)) association p(HGNC:BACE1) |
| pubmed:23516100 | act(p(HGNCGENEFAMILY:Calpains)) increases a(CHEBI:"amyloid-beta polypeptide 40") |
| pubmed:23516100 | act(p(HGNCGENEFAMILY:Calpains)) increases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:23516100 | act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:SNCA, frag("?")) |
| pubmed:30985105 | p(HGNCGENEFAMILY:Calpains) increases p(HGNC:SNCA, frag("?")) |
| pubmed:30985105 | act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:SNCA, frag("?")) |
| pubmed:23516100 | act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:ATXN3, frag("?")) |
| pubmed:24027553 | act(p(HGNCGENEFAMILY:Calpains)) increases deg(p(HGNC:MAPT)) |
| pubmed:24027553 | act(p(HGNCGENEFAMILY:Calpains)) increases deg(p(HGNC:MAPT)) |
| pubmed:24027553 | act(p(HGNCGENEFAMILY:Calpains)) increases deg(p(HGNC:MAPT)) |
| pubmed:24027553 | p(HGNCGENEFAMILY:Calpains) association path(MESH:"Neurodegenerative Diseases") |
| pubmed:24027553 | act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("?", "35kD")) |
| pubmed:24027553 | act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("?", "17kD")) |
| pubmed:24027553 | act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("?", "17kD")) |
| pubmed:24027553 | act(p(HGNCGENEFAMILY:Calpains)) association path(CONSO:Excitotoxicity) |
| pubmed:24027553 | act(p(HGNCGENEFAMILY:Calpains)) increases path(CONSO:Neurodegeneration) |
| pubmed:30985105 | p(HGNCGENEFAMILY:Calpains) increases p(CONSO:"alpha-synuclein fibrils", frag("?")) |
| pubmed:30985105 | act(p(HGNCGENEFAMILY:Calpains)) association path(MESH:"Parkinson Disease") |
| pubmed:30985105 | act(p(HGNCGENEFAMILY:Calpains)) association path(MESH:"Parkinson Disease") |
| pubmed:30985105 | p(HGNCGENEFAMILY:Calpains) causesNoChange deg(p(HGNC:SNCA, pmod(CONSO:O-GlcNAcylation, Thr, 72))) |
| pubmed:30985105 | p(HGNCGENEFAMILY:Calpains) causesNoChange deg(p(HGNC:SNCA, pmod(CONSO:O-GlcNAcylation, Ser, 87))) |
| pubmed:30985105 | p(HGNCGENEFAMILY:Calpains) increases deg(p(HGNC:SNCA)) |
| pubmed:31346362 | act(p(MESH:Deoxyribonucleases)) increases bp(GO:"cell death") |
| pubmed:31346362 | g(HGNC:VEGFA) increases bp(GO:angiogenesis) |
| pubmed:27190210 | bp(GO:angiogenesis) association p(HGNC:CHRNA7) |
| pubmed:31346362 | p(HGNC:SLC2A1) increases bp(GO:"glycolytic process") |
| pubmed:21861815 | p(HGNC:SLC2A1) regulates bp(GO:"glucose import") |
| pubmed:29626319 | p(HGNC:SLC2A1) increases p(HGNC:LRP1) |
| pubmed:29626319 | p(HGNC:SLC2A1) regulates deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | p(HGNC:SLC2A1) regulates tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:Brain), toLoc(MESH:Blood)) |
| pubmed:29626319 | p(HGNC:SLC2A1) regulates tloc(a(CHEBI:glucose), fromLoc(GO:"extracellular region"), toLoc(MESH:"Blood-Brain Barrier")) |
| pubmed:29626319 | p(HGNC:SLC2A1) regulates a(MESH:"Blood-Brain Barrier") |
| pubmed:31346362 | p(HGNC:HK2) increases bp(GO:"glycolytic process") |
| pubmed:31346362 | a(MESH:Alarmins) increases bp(GO:"inflammatory response") |
| pubmed:24561250 | a(MESH:Alarmins) increases complex(GO:"inflammasome complex") |
| pubmed:24561250 | a(MESH:Alarmins) increases act(complex(GO:"inflammasome complex")) |
| pubmed:31346362 | a(MESH:Cytokines) increases bp(GO:"inflammatory response") |
| pubmed:30967783 | a(MESH:Cytokines) decreases bp(GO:"inflammatory response") |
| pubmed:27288790 | a(MESH:Cytokines) increases act(p(FPLX:"IKK_complex")) |
| pubmed:27288790 | a(MESH:Cytokines) directlyIncreases m(MIRBASE:hsa-mir-155) |
| pubmed:26551702 | a(MESH:Cytokines) positiveCorrelation p(HGNC:NFE2L2) |
| pubmed:26551702 | a(MESH:Cytokines) increases path(MESH:Gliosis) |
| pubmed:26551702 | a(MESH:Cytokines) increases bp(GO:"neuron death") |
| pubmed:26551702 | a(MESH:Cytokines) decreases bp(GO:myelination) |
| pubmed:26551702 | a(MESH:Cytokines) increases act(p(HGNC:BTRC)) |
| pubmed:30988501 | a(MESH:Cytokines) increases path(MESH:Inflammation) |
| pubmed:30967783 | a(MESH:Cytokines) increases path(MESH:Inflammation) |
| pubmed:27190210 | tloc(a(MESH:Cytokines), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases path(MESH:Inflammation) |
| pubmed:30967783 | a(MESH:Cytokines) increases a(MESH:"Leukocytes, Mononuclear", loc(NCIT:C74601)) |
| pubmed:30967783 | a(MESH:Cytokines) increases deg(a(MESH:Tissues)) |
| pubmed:23092889 | a(MESH:Cytokines) increases bp(GO:pyroptosis) |
| pubmed:26979166 | a(MESH:Cytokines) increases deg(a(MESH:"White Matter")) |
| pubmed:26979166 | a(MESH:Cytokines) increases deg(a(MESH:"Gray Matter")) |
| pubmed:30988501 | a(MESH:Cytokines) increases a(CHEBI:"reactive oxygen species") |
| pubmed:30988501 | a(MESH:Cytokines) decreases bp(GO:"monoamine transport") |
| pubmed:30988501 | a(MESH:Cytokines) increases bp(GO:"synaptic transmission, glutamatergic") |
| pubmed:31346362 | p(MESH:"Matrix Metalloproteinases") increases bp(GO:"inflammatory response") |
| pubmed:26445701 | p(MESH:"Matrix Metalloproteinases") increases bp(MESH:"Transendothelial and Transepithelial Migration") |
| pubmed:26445701 | p(MESH:"Matrix Metalloproteinases") increases path(HP:"CNS demyelination") |
| pubmed:26445701 | p(MESH:"Matrix Metalloproteinases") increases path(MESH:"Diffuse Axonal Injury") |
| pubmed:26445701 | p(MESH:"Matrix Metalloproteinases") increases bp(GO:"positive regulation of oligodendrocyte apoptotic process") |
| pubmed:31346362 | bp(GO:"necrotic cell death") increases a(MESH:Alarmins) |
| pubmed:31346362 | p(HGNC:HMGB1) increases a(MESH:Alarmins) |
| pubmed:23092889 | p(HGNC:HMGB1) increases bp(GO:pyroptosis) |
| pubmed:26979166 | tloc(p(HGNC:HMGB1), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases path(MESH:Inflammation) |
| pubmed:31346362 | bp(GO:"ATP generation from ADP") increases a(MESH:Alarmins) |
| pubmed:31346362 | p(NCIT:C706) increases a(MESH:Alarmins) |
| pubmed:31346362 | complex(a(MESH:Alarmins), p(HGNC:AGER)) increases act(p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) |
| pubmed:31346362 | complex(a(MESH:Alarmins), p(HGNC:AGER)) increases act(p(HGNC:STAT3)) |
| pubmed:31346362 | complex(a(MESH:Alarmins), p(HGNC:AGER)) increases act(complex(GO:"transcription factor AP-1 complex")) |
| pubmed:27288790 | act(p(HGNC:AGER)) increases bp(GO:"MAPK cascade") |
| pubmed:26195256 | p(HGNC:AGER) increases tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:"Cardiovascular System"), toLoc(MESH:"Extracellular Space")) |
| pubmed:29626319 | p(HGNC:AGER) increases tloc(a(CHEBI:amyloid-beta), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:26195256 | p(HGNC:AGER) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:18494933 | act(p(HGNC:AGER)) positiveCorrelation p(FPLX:JNK, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25681682 | p(HGNC:AGER) negativeCorrelation bp(GO:aging) |
| pubmed:25681682 | p(HGNC:AGER) negativeCorrelation bp(MESH:"Body Mass Index") |
| pubmed:25681682 | act(p(HGNC:AGER)) association p(HGNC:AGER) |
| pubmed:25681682 | p(HGNC:AGER) association act(p(HGNC:AGER)) |
| pubmed:24183963 | act(p(HGNC:AGER)) increases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:25681350 | p(HGNC:STAT3) causesNoChange p(HGNC:CHI3L1) |
| pubmed:28745240 | p(HGNC:STAT3) increases bp(GO:"astrocyte development") |
| pubmed:19293145 | act(p(HGNC:STAT3)) association p(HGNC:JAK2) |
| pubmed:19293145 | act(p(HGNC:STAT3)) association a(CHEBI:nicotine) |
| pubmed:26979166 | act(p(HGNC:STAT3)) directlyIncreases act(p(MESH:"NF-kappa B")) |
| pubmed:30116051 | p(HGNC:STAT3) decreases bp(GO:macroautophagy) |
| pubmed:31346362 | complex(a(MESH:Alarmins), p(HGNC:P2RX7)) increases act(p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) |
| pubmed:31346362 | complex(a(MESH:Alarmins), p(HGNC:P2RX7)) increases act(p(HGNC:STAT3)) |
| pubmed:31346362 | complex(a(MESH:Alarmins), p(HGNC:P2RX7)) increases act(complex(GO:"transcription factor AP-1 complex")) |
| pubmed:24561250 | p(HGNC:P2RX7) increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pubmed:24561250 | p(HGNC:P2RX7) increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pubmed:27314526 | act(p(HGNC:P2RX7)) increases bp(GO:"inflammatory response") |
| pubmed:27314526 | act(p(HGNC:P2RX7)) increases bp(GO:"apoptotic process") |
| pubmed:27314526 | act(p(HGNC:P2RX7)) increases bp(GO:"cell proliferation") |
| pubmed:27314526 | p(HGNC:P2RX7) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:27314526 | p(HGNC:P2RX7) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:31346362 | complex(a(MESH:Alarmins), p(HGNCGENEFAMILY:"NLR family")) increases act(p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) |
| pubmed:31346362 | complex(a(MESH:Alarmins), p(HGNCGENEFAMILY:"NLR family")) increases act(p(HGNC:STAT3)) |
| pubmed:31346362 | complex(a(MESH:Alarmins), p(HGNCGENEFAMILY:"NLR family")) increases act(complex(GO:"transcription factor AP-1 complex")) |
| pubmed:31346362 | complex(a(MESH:Alarmins), complex(GO:"inflammasome complex")) increases act(p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) |
| pubmed:31346362 | complex(a(MESH:Alarmins), complex(GO:"inflammasome complex")) increases act(p(HGNC:STAT3)) |
| pubmed:31346362 | complex(a(MESH:Alarmins), complex(GO:"inflammasome complex")) increases act(complex(GO:"transcription factor AP-1 complex")) |
| pubmed:31346362 | act(complex(GO:"inflammasome complex")) increases bp(GO:"inflammatory response") |
| pubmed:31346362 | act(complex(GO:"inflammasome complex")) increases a(CHEBI:"reactive oxygen species") |
| pubmed:31346362 | complex(GO:"inflammasome complex") positiveCorrelation a(CHEBI:"reactive oxygen species") |
| pubmed:31346362 | complex(GO:"inflammasome complex") positiveCorrelation path(NCIT:C82901) |
| pubmed:23092889 | act(complex(GO:"inflammasome complex")) increases p(HGNC:HMGB1) |
| pubmed:23092889 | act(complex(GO:"inflammasome complex")) increases p(HGNC:HMGB1) |
| pubmed:23092889 | act(complex(GO:"inflammasome complex")) increases a(MESH:Cytokines) |
| pubmed:23092889 | act(complex(GO:"inflammasome complex")) increases p(HGNC:IL1B) |
| pubmed:23702978 | complex(GO:"inflammasome complex") increases act(p(HGNC:IL1B)) |
| pubmed:24561250 | complex(GO:"inflammasome complex") positiveCorrelation p(HGNC:IL1B) |
| pubmed:24561250 | complex(GO:"inflammasome complex") increases p(HGNC:IL1B) |
| pubmed:24561250 | complex(GO:"inflammasome complex") regulates p(HGNC:IL1B) |
| pubmed:27314526 | complex(GO:"inflammasome complex") increases act(p(HGNC:IL1B)) |
| pubmed:23092889 | act(complex(GO:"inflammasome complex")) increases p(HGNC:IL18) |
| pubmed:23702978 | complex(GO:"inflammasome complex") increases act(p(HGNC:IL18)) |
| pubmed:24561250 | complex(GO:"inflammasome complex") positiveCorrelation p(HGNC:IL18) |
| pubmed:24561250 | complex(GO:"inflammasome complex") increases p(HGNC:IL18) |
| pubmed:24561250 | act(complex(GO:"inflammasome complex")) increases p(HGNC:IL18) |
| pubmed:24561250 | complex(GO:"inflammasome complex") regulates p(HGNC:IL18) |
| pubmed:27314526 | complex(GO:"inflammasome complex") increases act(p(HGNC:IL18)) |
| pubmed:23702978 | complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) |
| pubmed:23702978 | complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) |
| pubmed:24561250 | act(complex(GO:"inflammasome complex")) increases act(p(HGNC:CASP1)) |
| pubmed:27314526 | act(complex(GO:"inflammasome complex")) increases act(p(HGNC:CASP1)) |
| pubmed:27314526 | complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) |
| pubmed:23702978 | act(complex(GO:"inflammasome complex")) increases bp(GO:pyroptosis) |
| pubmed:23702978 | complex(GO:"inflammasome complex") increases bp(GO:pyroptosis) |
| pubmed:27314526 | complex(GO:"inflammasome complex") increases bp(GO:pyroptosis) |
| pubmed:23702978 | complex(GO:"inflammasome complex") increases act(p(HGNC:SCAF11)) |
| pubmed:27314526 | complex(GO:"inflammasome complex") increases act(p(HGNC:IL33)) |
| pubmed:27314526 | complex(GO:"inflammasome complex") association path(MESH:"Alzheimer Disease") |
| pubmed:31346362 | p(HGNC:INSRR) increases bp(GO:"cellular respiration") |
| pubmed:31346362 | p(HGNC:INSRR) increases bp(GO:"cytokine production") |
| pubmed:31346362 | p(HGNC:INSRR) increases path(MESH:Inflammation) |
| pubmed:31346362 | act(p(HGNC:INSRR)) increases bp(GO:"cell death") |
| pubmed:31346362 | act(p(HGNC:INSRR)) increases deg(a(MESH:Tissues)) |
| pubmed:31346362 | act(p(HGNC:INSRR)) increases path(MESH:Fibrosis) |
| pubmed:31346362 | act(p(HGNC:INSRR)) increases deg(a(MESH:Neurons)) |
| pubmed:31346362 | act(p(HGNC:INSRR)) increases path(DOID:amyloidosis) |
| pubmed:30988501 | bp(GO:"cytokine production") increases bp(MESH:"Immunity, Innate") |
| pubmed:31346362 | deg(a(MESH:Tissues)) increases path(MESH:Fibrosis) |
| pubmed:27299292 | path(MESH:Fibrosis) negativeCorrelation p(HGNC:TFEB) |
| pubmed:26195256 | path(MESH:Fibrosis) decreases a(MESH:"Cerebrospinal Fluid") |
| pubmed:27889190 | a(MESH:Neurons) increases p(HGNC:LINGO1) |
| pubmed:27889190 | a(MESH:Neurons) increases bp(MESH:Remyelination) |
| pubmed:30967783 | act(a(MESH:Neurons)) positiveCorrelation a(MESH:Astrocytes) |
| pubmed:30967783 | act(a(MESH:Neurons)) negativeCorrelation bp(GO:"neuroinflammatory response") |
| pubmed:16340157 | a(MESH:Neurons) negativeCorrelation a(NIFT:"Grey matter atrophy") |
| pubmed:19126755 | a(MESH:Neurons) increases deg(a(CHEBI:nicotine)) |
| pubmed:19126755 | a(MESH:Neurons) association p(HGNC:CHRNA7) |
| pubmed:19126755 | a(MESH:Neurons) regulates a(CHEBI:"kynurenic acid") |
| pubmed:21482353 | a(MESH:Neurons) negativeCorrelation act(p(FPLX:CHRN)) |
| pubmed:21482353 | a(MESH:Neurons) increases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pubmed:28901280 | a(MESH:Neurons) association p(MESH:"Receptors, Nicotinic") |
| pubmed:30108137 | act(a(MESH:Neurons)) increases tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:24027553 | act(a(MESH:Neurons)) negativeCorrelation p(HGNC:MAPT) |
| pubmed:29238289 | act(a(MESH:Neurons)) increases tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:29238289 | act(a(MESH:Neurons)) increases tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27671637 | act(a(MESH:Neurons)) negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pubmed:17954934 | act(a(MESH:Neurons)) association p(HGNC:BAG1) |
| pubmed:31346362 | complex(a(CONSO:"amyloid-beta fibrils"), a(MESH:Alarmins), loc(GO:"extracellular region")) increases act(p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) |
| pubmed:31346362 | complex(a(CONSO:"amyloid-beta fibrils"), a(MESH:Alarmins), loc(GO:"extracellular region")) increases bp(GO:"cellular respiration") |
| pubmed:31346362 | complex(a(CONSO:"amyloid-beta fibrils"), a(MESH:Alarmins), loc(GO:"extracellular region")) increases bp(GO:"programmed cell death") |
| pubmed:31346362 | complex(a(CONSO:"amyloid-beta fibrils"), a(MESH:Alarmins), loc(GO:"extracellular region")) increases bp(GO:phagocytosis) |
| pubmed:31346362 | complex(a(CONSO:"amyloid-beta fibrils"), a(MESH:Alarmins), loc(GO:intracellular)) increases act(complex(GO:"inflammasome complex")) |
| pubmed:19293145 | a(CONSO:"amyloid-beta fibrils") isA a(CHEBI:amyloid-beta) |
| pubmed:17403556 | a(CONSO:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:17403556 | a(CONSO:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:17403556 | a(CONSO:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:17403556 | a(CONSO:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:17403556 | a(CONSO:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:17403556 | a(CONSO:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) |
| pubmed:30515821 | bp(GO:"programmed cell death") increases a(CHEBI:"reactive oxygen species") |
| pubmed:27299292 | bp(GO:"programmed cell death") negativeCorrelation p(HGNC:TFEB) |
| pubmed:18305152 | bp(GO:"programmed cell death") negativeCorrelation p(HGNC:TARDBP) |
| pubmed:18305152 | bp(GO:"programmed cell death") negativeCorrelation p(HGNC:TARDBP) |
| pubmed:31346362 | a(CHEBI:"reactive oxygen species") increases bp(GO:"cell death") |
| pubmed:31346362 | a(CHEBI:"reactive oxygen species") increases deg(a(MESH:Tissues)) |
| pubmed:31346362 | a(CHEBI:"reactive oxygen species") negativeCorrelation a(MESH:"Anti-Inflammatory Agents") |
| pubmed:31346362 | a(CHEBI:"reactive oxygen species") positiveCorrelation complex(GO:"inflammasome complex") |
| pubmed:28745240 | a(CHEBI:"reactive oxygen species") increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | a(CHEBI:"reactive oxygen species") increases bp(GO:neurogenesis) |
| pubmed:29179999 | a(CHEBI:"reactive oxygen species") increases act(p(FPLX:PKC)) |
| pubmed:29179999 | a(CHEBI:"reactive oxygen species") increases act(p(FPLX:ERK)) |
| pubmed:29179999 | a(CHEBI:"reactive oxygen species") increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pubmed:27288790 | a(CHEBI:"reactive oxygen species") increases act(p(FPLX:NFkappaB)) |
| pubmed:27288790 | a(CHEBI:"reactive oxygen species") regulates act(p(FPLX:NFkappaB)) |
| pubmed:27288790 | a(CHEBI:"reactive oxygen species") increases act(p(FPLX:"IKK_complex")) |
| pubmed:27288790 | a(CHEBI:"reactive oxygen species") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27288790 | a(CHEBI:"reactive oxygen species") association bp(MESH:"Membrane Fluidity") |
| pubmed:27288790 | a(CHEBI:"reactive oxygen species") association bp(GO:"ion transport") |
| pubmed:27288790 | a(CHEBI:"reactive oxygen species") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:27288790 | a(CHEBI:"reactive oxygen species") decreases bp(GO:autophagy) |
| pubmed:24563850 | a(CHEBI:"reactive oxygen species") regulates bp(GO:autophagy) |
| pubmed:23528736 | a(CHEBI:"reactive oxygen species") negativeCorrelation bp(GO:autophagy) |
| pubmed:27288790 | a(CHEBI:"reactive oxygen species") increases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26551702 | a(CHEBI:"reactive oxygen species") decreases complex(p(HGNC:KEAP1), p(HGNC:NFE2L2)) |
| pubmed:30962309 | a(CHEBI:"reactive oxygen species") increases p(HGNC:TXNIP) |
| pubmed:30962309 | a(CHEBI:"reactive oxygen species") increases p(HGNC:NLRP3) |
| pubmed:30962309 | a(CHEBI:"reactive oxygen species") increases p(HGNC:PYCARD) |
| pubmed:30962309 | a(CHEBI:"reactive oxygen species") increases p(HGNC:CASP1) |
| pubmed:30962309 | a(CHEBI:"reactive oxygen species") increases p(HGNC:IL1B) |
| pubmed:27794524 | a(CHEBI:"reactive oxygen species") directlyIncreases path(MESH:"Mitochondrial Diseases") |
| pubmed:27794524 | a(CHEBI:"reactive oxygen species") isA a(MESH:Neurotoxins) |
| pubmed:27794524 | tloc(a(CHEBI:"reactive oxygen species"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) directlyIncreases path(MESH:"Oxidative Stress") |
| pubmed:17017864 | a(CHEBI:"reactive oxygen species") increases path(CONSO:"mitochondrial dysfunction") |
| pubmed:30061532 | a(CHEBI:"reactive oxygen species") association path(MESH:Schizophrenia) |
| pubmed:30515821 | a(CHEBI:"reactive oxygen species") increases path(EFO:"neurotic disorder") |
| pubmed:30515821 | a(CHEBI:"reactive oxygen species") increases path(DOID:"neurodegenerative disease") |
| pubmed:30515821 | a(CHEBI:"reactive oxygen species") positiveCorrelation bp(GO:"regulation of NMDA receptor activity") |
| pubmed:30515821 | a(CHEBI:"reactive oxygen species") increases path(MESH:"Wounds and Injuries") |
| pubmed:30515821 | a(CHEBI:"reactive oxygen species") negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | a(CHEBI:"reactive oxygen species") increases path(OMIT:0002643) |
| pubmed:30688256 | a(CHEBI:"reactive oxygen species") increases bp(GO:mitophagy) |
| pubmed:30688256 | a(CHEBI:"reactive oxygen species") decreases bp(GO:mitophagy) |
| pubmed:30688256 | a(CHEBI:"reactive oxygen species") association bp(GO:mitophagy) |
| pubmed:30688256 | a(CHEBI:"reactive oxygen species") association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:24563850 | a(CHEBI:"reactive oxygen species") increases bp(GO:"negative regulation of inflammatory response") |
| pubmed:24563850 | a(CHEBI:"reactive oxygen species") regulates bp(GO:"response to hypoxia") |
| pubmed:24563850 | a(CHEBI:"reactive oxygen species") regulates bp(GO:"leukocyte activation") |
| pubmed:24563850 | a(CHEBI:"reactive oxygen species") regulates bp(GO:"cell differentiation") |
| pubmed:24563850 | a(CHEBI:"reactive oxygen species") regulates bp(GO:"integrin activation") |
| pubmed:28528849 | a(CHEBI:"reactive oxygen species") increases act(complex(GO:"NADPH oxidase complex")) |
| pubmed:16566606 | a(CHEBI:"reactive oxygen species") decreases act(a(MESH:Neurons)) |
| pubmed:16566606 | a(CHEBI:"reactive oxygen species") increases bp(GO:"neuron death") |
| pubmed:23702978 | a(CHEBI:"reactive oxygen species") increases act(p(HGNC:TRPM2)) |
| pubmed:23702978 | a(CHEBI:"reactive oxygen species") increases bp(GO:"apoptosome assembly") |
| pubmed:30988501 | a(CHEBI:"reactive oxygen species") increases path(CONSO:neurotoxicity) |
| pubmed:21861815 | path(EFO:hypoxia) negativeCorrelation bp(GO:"energy homeostasis") |
| pubmed:21861815 | path(EFO:hypoxia) increases bp(GO:"neuron death") |
| pubmed:21861815 | path(EFO:hypoxia) increases path(DOID:"Alzheimer's disease") |
| pubmed:21861815 | path(EFO:hypoxia) increases p(HGNC:BACE1) |
| pubmed:21861815 | path(EFO:hypoxia) increases complex(GO:"gamma-secretase complex") |
| pubmed:21861815 | path(EFO:hypoxia) increases a(CHEBI:amyloid-beta) |
| pubmed:21861815 | path(EFO:hypoxia) increases a(CONSO:"amyloid-beta aggregates") |
| pubmed:21861815 | path(EFO:hypoxia) increases r(HGNC:TH) |
| pubmed:31346362 | path(NCIT:C82901) increases deg(a(MESH:Tissues)) |
| pubmed:31346362 | path(NCIT:C82901) negativeCorrelation a(MESH:"Anti-Inflammatory Agents") |
| pubmed:31346362 | path(NCIT:C82901) positiveCorrelation complex(GO:"inflammasome complex") |
| pubmed:31346362 | act(p(HGNC:PROC, var("?"))) decreases p(HGNC:BACE1, loc(GO:"neuron part")) |
| pubmed:31346362 | act(p(HGNC:PROC, var("?"))) decreases p(HGNC:APP) |
| pubmed:31346362 | act(p(HGNC:PROC, var("?"))) decreases path(DOID:"Alzheimer's disease") |
| pubmed:28760828 | path(DOID:"Alzheimer's disease") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) |
| pubmed:28760828 | path(DOID:"Alzheimer's disease") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) |
| pubmed:21427723 | path(DOID:"Alzheimer's disease") association path(CONSO:"4R tauopathy") |
| pubmed:21427723 | path(DOID:"Alzheimer's disease") association complex(p(CONSO:"3R tau"), p(CONSO:"4R tau")) |
| pubmed:25031639 | path(DOID:"Alzheimer's disease") negativeCorrelation bp(GO:"axonal transport") |
| pubmed:25031639 | path(DOID:"Alzheimer's disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:29661268 | path(DOID:"Alzheimer's disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:29661268 | path(DOID:"Alzheimer's disease") increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:25031639 | path(DOID:"Alzheimer's disease") increases p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25031639 | path(DOID:"Alzheimer's disease") decreases p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:25031639 | path(DOID:"Alzheimer's disease") decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:25031639 | path(DOID:"Alzheimer's disease") increases act(p(HGNC:HDAC6)) |
| pubmed:25031639 | path(DOID:"Alzheimer's disease") negativeCorrelation a(MESH:Microtubules) |
| pubmed:29661268 | path(DOID:"Alzheimer's disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) |
| pubmed:29661268 | path(DOID:"Alzheimer's disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) |
| pubmed:29661268 | path(DOID:"Alzheimer's disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281)) |
| pubmed:29661268 | path(DOID:"Alzheimer's disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) |
| pubmed:29661268 | path(DOID:"Alzheimer's disease") decreases act(p(HGNC:PPP2CA)) |
| pubmed:29661268 | path(DOID:"Alzheimer's disease") increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:29661268 | path(DOID:"Alzheimer's disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:29661268 | path(DOID:"Alzheimer's disease") increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:29661268 | path(DOID:"Alzheimer's disease") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:30515821 | path(DOID:"Alzheimer's disease") negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:27190210 | path(DOID:"Alzheimer's disease") decreases p(HGNC:CHRNA7) |
| pubmed:22530628 | path(DOID:"Alzheimer's disease") decreases p(HGNC:CHRNA7) |
| pubmed:22530628 | path(DOID:"Alzheimer's disease") association p(HGNC:CHRNA7) |
| pubmed:22530628 | path(DOID:"Alzheimer's disease") decreases p(HGNC:CHRNA7) |
| pubmed:27190210 | path(DOID:"Alzheimer's disease") association g(HGNC:CHRNA7) |
| pubmed:27190210 | path(DOID:"Alzheimer's disease") association complex(CONSO:"alpha-7 beta-2 nAChR") |
| pubmed:22530628 | path(DOID:"Alzheimer's disease") increases path(MESH:"Memory Disorders") |
| pubmed:22530628 | path(DOID:"Alzheimer's disease") decreases a(CHEBI:acetylcholine) |
| pubmed:22530628 | path(DOID:"Alzheimer's disease") decreases p(HGNC:CHRNA3) |
| pubmed:22530628 | path(DOID:"Alzheimer's disease") decreases p(HGNC:CHRNA4) |
| pubmed:22530628 | path(DOID:"Alzheimer's disease") decreases act(p(HGNC:CHAT)) |
| pubmed:22530628 | path(DOID:"Alzheimer's disease") negativeCorrelation path(MESH:"Tobacco Use") |
| pubmed:22530628 | path(DOID:"Alzheimer's disease") decreases complex(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:31248781 | path(DOID:"Alzheimer's disease") decreases path(MESH:Attention) |
| pubmed:31248781 | path(DOID:"Alzheimer's disease") decreases path(MESH:Orientation) |
| pubmed:31248781 | path(DOID:"Alzheimer's disease") decreases bp(GO:"learning or memory") |
| pubmed:31248781 | path(DOID:"Alzheimer's disease") decreases path(MESH:"Executive Function") |
| pubmed:31248781 | path(DOID:"Alzheimer's disease") decreases path(MESH:Judgment) |
| pubmed:31248781 | path(DOID:"Alzheimer's disease") increases path(MESH:"Language Disorders") |
| pubmed:31248781 | path(DOID:"Alzheimer's disease") increases path(DOID:"mental depression") |
| pubmed:31248781 | path(DOID:"Alzheimer's disease") increases path(MESH:"Anxiety Disorders") |
| pubmed:31248781 | path(DOID:"Alzheimer's disease") increases path(HP:Agitation) |
| pubmed:31248781 | path(DOID:"Alzheimer's disease") increases path(DOID:"sleep disorder") |
| pubmed:31248781 | path(DOID:"Alzheimer's disease") decreases p(HGNC:CREBBP) |
| pubmed:29428175 | path(DOID:"Alzheimer's disease") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:26979166 | path(DOID:"Alzheimer's disease") positiveCorrelation path(MESH:Smoking) |
| pubmed:26979166 | path(DOID:"Alzheimer's disease") positiveCorrelation path(MESH:Smoking) |
| pubmed:23516100 | path(DOID:"Alzheimer's disease") increases p(HGNC:MAPT, frag("?"), loc(CONSO:"paired helical filaments")) |
| pubmed:23516100 | path(DOID:"Alzheimer's disease") positiveCorrelation p(HGNC:MAPT, frag("?")) |
| pubmed:23516100 | path(DOID:"Alzheimer's disease") increases p(HGNC:MAPT, frag("1_391"), loc(CONSO:"paired helical filaments")) |
| pubmed:23516100 | path(DOID:"Alzheimer's disease") increases p(HGNC:MAPT, frag("1_421")) |
| pubmed:23516100 | path(DOID:"Alzheimer's disease") increases p(HGNC:APP, frag("1_?")) |
| pubmed:23516100 | path(DOID:"Alzheimer's disease") increases a(CHEBI:amyloid-beta) |
| pubmed:23516100 | path(DOID:"Alzheimer's disease") increases complex(complex(GO:"mitochondrial protein complex"), p(HGNC:APP, frag("1_?"))) |
| pubmed:23516100 | path(DOID:"Alzheimer's disease") negativeCorrelation bp(GO:"calcium ion homeostasis") |
| pubmed:23516100 | path(DOID:"Alzheimer's disease") decreases act(p(HGNCGENEFAMILY:Calpains)) |
| pubmed:23516100 | path(DOID:"Alzheimer's disease") positiveCorrelation act(p(HGNCGENEFAMILY:Calpains)) |
| pubmed:23516100 | path(DOID:"Alzheimer's disease") negativeCorrelation bp(GO:"cytoskeleton organization") |
| pubmed:23516100 | path(DOID:"Alzheimer's disease") increases p(HGNC:MAPT, frag("?_*")) |
| pubmed:23516100 | path(DOID:"Alzheimer's disease") increases p(HGNC:CASP3) |
| pubmed:23516100 | path(DOID:"Alzheimer's disease") increases p(HGNC:TARDBP, frag("?")) |
| pubmed:23516100 | path(DOID:"Alzheimer's disease") negativeCorrelation a(GO:lysosome) |
| pubmed:23516100 | path(DOID:"Alzheimer's disease") increases p(HGNC:CTSD) |
| pubmed:23516100 | path(DOID:"Alzheimer's disease") increases p(HGNC:APP, frag("1_35")) |
| pubmed:21861815 | path(DOID:"Alzheimer's disease") decreases bp(NCIT:C94869) |
| pubmed:21861815 | path(DOID:"Alzheimer's disease") negativeCorrelation bp(GO:"glucose metabolic process") |
| pubmed:21861815 | path(DOID:"Alzheimer's disease") negativeCorrelation bp(GO:"glucose import") |
| pubmed:21861815 | path(DOID:"Alzheimer's disease") increases bp(NCIT:C17741) |
| pubmed:21861815 | path(DOID:"Alzheimer's disease") decreases r(HGNC:SLC2A1) |
| pubmed:21861815 | path(DOID:"Alzheimer's disease") decreases r(HGNC:SLC2A3) |
| pubmed:26968346 | path(DOID:"Alzheimer's disease") increases m(MIRBASE:hsa-mir-128-1) |
| pubmed:27299292 | path(DOID:"Alzheimer's disease") increases m(MIRBASE:hsa-mir-128-1) |
| pubmed:26968346 | path(DOID:"Alzheimer's disease") increases m(MIRBASE:hsa-mir-128-2) |
| pubmed:27299292 | path(DOID:"Alzheimer's disease") decreases p(HGNC:TFEB) |
| pubmed:27299292 | path(DOID:"Alzheimer's disease") negativeCorrelation p(HGNC:PSEN1) |
| pubmed:23384725 | path(DOID:"Alzheimer's disease") association composite(a(MESH:"Inclusion Bodies"), p(HGNC:TARDBP)) |
| pubmed:28669544 | path(DOID:"Alzheimer's disease") directlyIncreases path(MESH:"Neuronal Plasticity") |
| pubmed:30988501 | path(DOID:"Alzheimer's disease") positiveCorrelation a(MESH:"Herpesvirus 1, Human") |
| pubmed:31346362 | p(OMIT:0018975) decreases p(MESH:Proteins, pmod(MESH:Polymers)) |
| pubmed:31346362 | p(OMIT:0018975) decreases p(CONSO:"amyloid-beta aggregates") |
| pubmed:30606258 | p(MESH:Proteins, loc(GO:"synaptic membrane")) negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) |
| pubmed:31346362 | a(CHEBI:"acetylsalicylic acid") decreases p(MESH:Proteins, pmod(MESH:Polymers)) |
| pubmed:31346362 | a(CHEBI:"acetylsalicylic acid") decreases p(CONSO:"amyloid-beta aggregates") |
| pubmed:31346362 | a(CHEBI:"acetylsalicylic acid") increases p(MESH:Proteins, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:31346362 | a(CHEBI:"acetylsalicylic acid") decreases p(MESH:Proteins, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:31346362 | a(CHEBI:"acetylsalicylic acid") decreases p(HGNCGENEFAMILY:"NF-kappa B complex subunits") |
| pubmed:31346362 | a(CHEBI:"acetylsalicylic acid") decreases p(MESH:"Prostaglandin-Endoperoxide Synthases") |
| pubmed:21329555 | a(CHEBI:"acetylsalicylic acid") decreases r(HGNC:BACE1) |
| pubmed:21329555 | a(CHEBI:"acetylsalicylic acid") decreases r(HGNC:BACE1) |
| pubmed:21329555 | a(CHEBI:"acetylsalicylic acid") isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") |
| pubmed:31346362 | p(MESH:Proteins, pmod(go:0006473 ! "protein acetylation")) decreases p(MESH:Proteins, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:31346362 | a(CHEBI:digoxin) decreases p(HGNC:HIF1A) |
| pubmed:31346362 | a(PUBCHEM:443101) decreases p(HGNC:HIF1A) |
| pubmed:31346362 | a(CHEBI:doxorubicin) decreases p(HGNC:HIF1A) |
| pubmed:26751493 | a(CHEBI:doxorubicin) decreases p(CONSO:"Tau aggregates") |
| pubmed:31346362 | a(CHEBI:chetomin) decreases p(HGNC:HIF1A) |
| pubmed:31346362 | a(MESH:"Anti-Inflammatory Agents") negativeCorrelation path(NCIT:C82901) |
| pubmed:31346362 | a(MESH:"Anti-Inflammatory Agents") negativeCorrelation a(CHEBI:"reactive oxygen species") |
| pubmed:31346362 | a(CHEBI:curcumin) decreases p(MESH:"Glycation End Products, Advanced") |
| pubmed:31346362 | deg(a(CHEBI:curcumin)) increases a(CHEBI:vanillin) |
| pubmed:29179999 | a(CHEBI:curcumin) decreases bp(GO:"inflammatory response") |
| pubmed:29179999 | a(CHEBI:curcumin) decreases p(HGNC:PTGS2) |
| pubmed:29179999 | a(CHEBI:curcumin) decreases p(HGNC:LOX) |
| pubmed:29179999 | a(CHEBI:curcumin) decreases p(HGNC:NOS2) |
| pubmed:29179999 | a(CHEBI:curcumin) decreases p(HGNC:TNF) |
| pubmed:29179999 | a(CHEBI:curcumin) decreases p(HGNC:IL1A) |
| pubmed:29179999 | a(CHEBI:curcumin) decreases p(HGNC:IL2) |
| pubmed:29179999 | a(CHEBI:curcumin) decreases p(HGNC:IL6) |
| pubmed:29179999 | a(CHEBI:curcumin) decreases p(HGNC:CXCL8) |
| pubmed:29179999 | a(CHEBI:curcumin) decreases p(HGNC:IL12B) |
| pubmed:29179999 | a(CHEBI:curcumin) decreases a(MESH:Neurotoxins) |
| pubmed:29179999 | a(CHEBI:curcumin) decreases act(p(FPLX:NFkappaB)) |
| pubmed:29179999 | a(CHEBI:curcumin) decreases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29179999 | a(CHEBI:curcumin) decreases deg(p(HGNC:NFKBIA)) |
| pubmed:29179999 | a(CHEBI:curcumin) decreases tloc(p(HGNC:RELA), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pubmed:26551702 | a(CHEBI:curcumin) decreases path(MESH:Inflammation) |
| pubmed:26551702 | a(CHEBI:curcumin) increases act(p(HGNC:NFE2L2)) |
| pubmed:26551702 | a(CHEBI:curcumin) increases bp(GO:"response to oxidative stress") |
| pubmed:22530628 | a(CHEBI:curcumin) decreases a(CONSO:"amyloid-beta oligomers") |
| pubmed:30116051 | a(CHEBI:curcumin) decreases a(CONSO:"amyloid-beta oligomers") |
| pubmed:22530628 | a(CHEBI:curcumin) causesNoChange a(CONSO:"amyloid-beta fibrils") |
| pubmed:28803412 | a(CHEBI:curcumin) decreases a(CONSO:CONSO00092) |
| pubmed:28803412 | a(CHEBI:curcumin) decreases a(CONSO:CONSO00016) |
| pubmed:28803412 | a(CHEBI:curcumin) decreases a(CONSO:CONSO00018) |
| pubmed:30116051 | a(CHEBI:curcumin) increases bp(GO:macroautophagy) |
| pubmed:30116051 | a(CHEBI:curcumin) decreases act(p(FPLX:mTORC1)) |
| pubmed:30116051 | a(CHEBI:curcumin) increases deg(p(HGNC:SNCA, var("p.Ala53Thr"))) |
| pubmed:30116051 | a(CHEBI:curcumin) decreases a(CONSO:"alpha-synuclein aggregates") |
| pubmed:30116051 | a(CHEBI:curcumin) decreases a(CONSO:"Tau oligomers") |
| pubmed:31346362 | a(CHEBI:vanillin) decreases p(MESH:"Glycation End Products, Advanced") |
| pubmed:22530628 | a(CHEBI:vanillin) decreases a(CONSO:"amyloid-beta oligomers") |
| pubmed:22530628 | a(CHEBI:vanillin) decreases a(CONSO:"amyloid-beta fibrils") |
| pubmed:31346362 | path(EFO:"physical activity") decreases path(DOID:"Alzheimer's disease") |
| pubmed:31346362 | p(HGNC:BDNF) decreases bp(GO:"programmed cell death") |
| pubmed:28745240 | p(HGNC:BDNF) increases bp(MESH:"Neuronal Outgrowth") |
| pubmed:28745240 | p(HGNC:BDNF) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | p(HGNC:BDNF) increases act(p(HGNC:SRC)) |
| pubmed:27794524 | p(HGNC:BDNF) association bp(GO:"axon development") |
| pubmed:30967783 | p(HGNC:BDNF) increases act(p(HGNC:NTRK2)) |
| pubmed:30967783 | p(HGNC:BDNF) increases a(GO:synapse) |
| pubmed:30967783 | p(HGNC:BDNF) increases bp(GO:"learning or memory") |
| pubmed:21677163 | p(HGNC:BDNF) positiveCorrelation p(FPLX:CREB) |
| pubmed:11880483 | p(HGNC:BDNF) association p(HGNCGENEFAMILY:"Mitogen-activated protein kinases", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:11880483 | p(HGNC:BDNF) association p(FPLX:p38, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26876488 | p(HGNC:BDNF) decreases a(NIFT:"Cortical Thickness") |
| pubmed:22530628 | p(HGNC:BDNF) increases p(HGNC:ARC) |
| pubmed:31248781 | p(HGNC:BDNF) regulates bp(MESH:"Neuronal Plasticity") |
| pubmed:22040696 | p(HGNC:BDNF) regulates bp(GO:"peripheral nervous system development") |
| pubmed:22040696 | p(HGNC:BDNF) regulates bp(GO:"central nervous system development") |
| pubmed:22040696 | p(HGNC:BDNF) increases bp(GO:"regulation of synaptic plasticity") |
| pubmed:22040696 | p(HGNC:BDNF) increases bp(GO:"spontaneous synaptic transmission") |
| pubmed:22040696 | p(HGNC:BDNF) increases bp(GO:"synaptic transmission, GABAergic") |
| pubmed:22040696 | p(HGNC:BDNF) increases bp(GO:"maintenance of synapse structure") |
| pubmed:22040696 | p(HGNC:BDNF) association p(HGNC:CHRNA7) |
| pubmed:22040696 | p(HGNC:BDNF) increases p(HGNC:CHRNA7) |
| pubmed:22040696 | p(HGNC:BDNF) increases tloc(p(HGNC:CHRNA7), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) |
| pubmed:22179319 | p(HGNC:BDNF) increases path(MESH:Neuroprotection) |
| pubmed:22179319 | p(HGNC:BDNF) increases bp(GO:"striatal medium spiny neuron differentiation") |
| pubmed:22179319 | p(HGNC:BDNF) decreases path(MESH:"Nerve Degeneration") |
| pubmed:22179319 | p(HGNC:BDNF) regulates path(MESH:"Carbohydrate Metabolism") |
| pubmed:22179319 | p(HGNC:BDNF) decreases a(MESH:"Blood Glucose") |
| pubmed:22179319 | p(HGNC:BDNF) association p(HGNC:PPP1R1B) |
| pubmed:27013968 | act(p(HGNC:BDNF), ma(GO:"brain-derived neurotrophic factor binding")) negativeCorrelation p(HGNC:HTT, pmod(HBP:"CAG repeats")) |
| pubmed:27013968 | p(HGNC:BDNF) increases act(p(HGNC:NTRK2, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:27013968 | p(HGNC:BDNF) increases p(HGNC:NTRK2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27013968 | p(HGNC:BDNF) increases bp(MESH:"Cell Survival") |
| pubmed:27013968 | p(HGNC:BDNF) increases bp(MESH:"Cell Survival") |
| pubmed:27013968 | p(HGNC:BDNF) increases p(PFAM:DARPP-32) |
| pubmed:27013968 | p(HGNC:BDNF) increases p(PFAM:DARPP-32) |
| pubmed:27013968 | p(HGNC:BDNF) decreases bp(MESH:Apoptosis) |
| pubmed:30027901 | p(HGNC:BDNF) increases bp(GO:"cell growth") |
| pubmed:30027901 | p(HGNC:BDNF) biomarkerFor bp(MESH:Neuroprotection) |
| pubmed:30740335 | p(HGNC:BDNF) regulates path(MESH:"Neuronal Plasticity") |
| pubmed:30740335 | p(HGNC:BDNF) regulates path(MESH:"Long-Term Potentiation") |
| pubmed:30740335 | p(HGNC:BDNF) association act(p(HGNC:XBP1)) |
| pubmed:30985105 | p(HGNC:BDNF) association p(HGNC:HTT) |
| pubmed:28632203 | p(HGNC:BDNF) biomarkerFor path(MESH:"Alzheimer Disease") |
| pubmed:31346362 | p(HGNC:IGF1) decreases bp(GO:"programmed cell death") |
| pubmed:27794524 | p(HGNC:IGF1) association bp(GO:"axon development") |
| pubmed:30967783 | p(HGNC:IGF1) increases bp(MESH:"Cell Survival") |
| pubmed:30967783 | p(HGNC:IGF1) increases bp(GO:neurogenesis) |
| pubmed:31346362 | a(CHEBI:testosterone) decreases bp(GO:"programmed cell death") |
| pubmed:21214928 | a(CHEBI:testosterone) decreases path(MESH:"Plaque, Amyloid") |
| pubmed:21214928 | a(CHEBI:testosterone) decreases r(HGNC:BACE1) |
| pubmed:21214928 | a(CHEBI:testosterone) decreases p(HGNC:BACE1) |
| pubmed:21214928 | a(CHEBI:testosterone) decreases act(p(HGNC:BACE1)) |
| pubmed:21214928 | a(CHEBI:testosterone) decreases p(HGNC:PSEN1) |
| pubmed:31346362 | act(p(HGNC:SIRT1)) decreases bp(GO:"programmed cell death") |
| pubmed:28745240 | p(HGNC:SIRT1) decreases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | p(HGNC:SIRT1) decreases path(CONSO:neurotoxicity) |
| pubmed:22372633 | p(HGNC:SIRT1) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:20869593 | p(HGNC:SIRT1) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:29540553 | p(HGNC:SIRT1) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) |
| pubmed:29540553 | p(HGNC:SIRT1) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) |
| pubmed:29540553 | p(HGNC:SIRT1) decreases p(HGNC:MAPT) |
| pubmed:29661268 | act(p(HGNC:SIRT1)) negativeCorrelation p(HGNC:MAPT) |
| pubmed:29540553 | p(HGNC:SIRT1) positiveCorrelation bp(GO:"learning or memory") |
| pubmed:22020111 | p(HGNC:SIRT1) decreases p(HGNC:NFE2L2, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:22179319 | p(HGNC:SIRT1) association path(MESH:Metabolism) |
| pubmed:22179319 | p(HGNC:SIRT1) isA p(HGNCGENEFAMILY:Sirtuins) |
| pubmed:22179319 | p(HGNC:SIRT1) causesNoChange p(HGNC:HTT, pmod(CONSO:"CAG repeats")) |
| pubmed:22179319 | p(HGNC:SIRT1) causesNoChange p(HGNC:HTT, pmod(CONSO:"CAG repeats")) |
| pubmed:22179319 | p(HGNC:SIRT1) decreases path(MESH:"Motor Disorders") |
| pubmed:22179319 | p(HGNC:SIRT1) decreases path(MESH:"Motor Disorders") |
| pubmed:22179319 | p(HGNC:SIRT1) decreases path(MESH:"Pick Disease of the Brain") |
| pubmed:22179319 | p(HGNC:SIRT1) decreases path(MESH:"Pick Disease of the Brain") |
| pubmed:22179319 | p(HGNC:SIRT1) decreases path(CONSO:Neurodegeneration) |
| pubmed:22179319 | p(HGNC:SIRT1) decreases path(CONSO:Neurodegeneration) |
| pubmed:22179319 | p(HGNC:SIRT1) increases path(MESH:"Motor Activity") |
| pubmed:22179319 | p(HGNC:SIRT1) decreases path(MESH:Hyperglycemia) |
| pubmed:22179319 | p(HGNC:SIRT1) increases path(MESH:"Glucose Intolerance") |
| pubmed:22179319 | p(HGNC:SIRT1) decreases path(MESH:"Weight Loss") |
| pubmed:22179319 | p(HGNC:SIRT1) causesNoChange path(MESH:"Energy Metabolism") |
| pubmed:22179319 | p(HGNC:SIRT1) decreases a(MESH:Insulins) |
| pubmed:22179319 | p(HGNC:SIRT1) increases path(MESH:"Insulin Resistance") |
| pubmed:22179319 | p(HGNC:SIRT1) causesNoChange path(MESH:Longevity) |
| pubmed:22179319 | p(HGNC:SIRT1) causesNoChange a(CONSO:"huntingtin aggregates") |
| pubmed:22179319 | p(HGNC:SIRT1) increases p(HGNC:PPP1R1B) |
| pubmed:22179319 | p(HGNC:SIRT1) increases p(HGNC:BDNF) |
| pubmed:22179319 | p(HGNC:SIRT1) increases p(HGNC:NTRK2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22179319 | p(HGNC:SIRT1) causesNoChange p(HGNC:NTRK2) |
| pubmed:22179319 | p(HGNC:SIRT1) increases path(MESH:"Cell Survival") |
| pubmed:22179319 | p(HGNC:SIRT1) decreases p(HGNC:FOXO3, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:22179319 | p(HGNC:SIRT1) increases p(HGNC:FOXO3) |
| pubmed:30116051 | act(p(HGNC:SIRT1)) increases act(p(HGNC:FOXO3)) |
| pubmed:22179319 | p(HGNC:SIRT1) increases a(CHEBI:ATP) |
| pubmed:22179319 | p(HGNC:SIRT1) decreases p(HGNC:TP53, pmod(go:0006473 ! "protein acetylation", Lys, 382)) |
| pubmed:27209302 | act(p(HGNC:SIRT1)) decreases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:27209302 | p(HGNC:SIRT1) decreases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:27209302 | p(HGNC:SIRT1) directlyDecreases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:27209302 | act(p(HGNC:SIRT1), ma(GO:"deacetylase activity")) decreases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:27209302 | p(HGNC:SIRT1) decreases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation", Lys, 116)) |
| pubmed:27209302 | act(p(HGNC:SIRT1), ma(GO:"NAD+ binding")) decreases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation", Lys, 116)) |
| pubmed:27209302 | p(HGNC:SIRT1) increases act(p(HGNC:SIRT1)) |
| pubmed:27209302 | act(p(HGNC:SIRT1)) increases bp(GO:"microglial cell activation") |
| pubmed:27209302 | act(p(HGNC:SIRT1), ma(GO:"deacetylase activity")) increases bp(GO:"microglial cell activation") |
| pubmed:27209302 | p(HGNC:SIRT1) increases a(MESH:Lysosomes) |
| pubmed:27209302 | act(p(HGNC:SIRT1), ma(GO:"deacetylase activity")) increases a(MESH:Lysosomes) |
| pubmed:27209302 | act(p(HGNC:SIRT1), ma(GO:"deacetylase activity")) increases act(a(MESH:Lysosomes)) |
| pubmed:27209302 | p(HGNC:SIRT1) increases p(HGNC:TFEB) |
| pubmed:27209302 | p(HGNC:SIRT1) increases act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:30116051 | act(p(HGNC:SIRT1)) decreases act(p(FPLX:mTORC1)) |
| pubmed:30116051 | act(p(HGNC:SIRT1)) increases act(p(HGNC:FOXO1)) |
| pubmed:30116051 | act(p(HGNC:SIRT1)) increases act(p(HGNC:ATG5)) |
| pubmed:30116051 | act(p(HGNC:SIRT1)) increases act(p(HGNC:ATG7)) |
| pubmed:30116051 | act(p(HGNC:SIRT1)) increases act(p(HGNC:MAP1LC3A)) |
| pubmed:30116051 | act(p(HGNC:SIRT1)) negativeCorrelation bp(GO:aging) |
| pubmed:26631930 | p(HGNC:SIRT1) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys)) |
| pubmed:20869593 | act(p(HGNC:SIRT1)) negativeCorrelation p(CONSO:"Tau epitope, AT8") |
| pubmed:29540553 | p(HGNC:SIRT1) decreases path(CONSO:"Pathological Tau Spreading") |
| pubmed:29540553 | act(p(HGNC:SIRT1)) decreases path(MESH:"Alzheimer Disease") |
| pubmed:29540553 | p(HGNC:SIRT1) decreases path(MESH:"Alzheimer Disease") |
| pubmed:29540553 | act(p(HGNC:SIRT1)) decreases path(HP:Neurodegeneration) |
| pubmed:29540553 | p(HGNC:SIRT1) decreases path(HP:Neurodegeneration) |
| pubmed:29540553 | p(HGNC:SIRT1) increases bp(GO:learning) |
| pubmed:29540553 | p(HGNC:SIRT1) increases bp(GO:memory) |
| pubmed:29226865 | act(p(HGNC:SIRT1)) directlyDecreases p(HGNC:SRSF2, pmod(go:0006473 ! "protein acetylation", Lys, 52)) |
| pubmed:25681350 | a(PUBCHEM:14235) increases r(MGI:"chitinase-like 1") |
| pubmed:25681350 | a(PUBCHEM:14235) increases r(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") |
| pubmed:25681350 | r(MGI:"chitinase-like 1") positiveCorrelation r(MGI:"interleukin 1 alpha") |
| pubmed:25681350 | r(MGI:"chitinase-like 1") positiveCorrelation r(MGI:"interleukin 6") |
| pubmed:25681350 | r(MGI:"interleukin 1 alpha") positiveCorrelation r(MGI:"chitinase-like 1") |
| pubmed:25681350 | r(MGI:"interleukin 6") positiveCorrelation r(MGI:"chitinase-like 1") |
| pubmed:25681350 | p(MGI:"myelin oligodendrocyte glycoprotein", frag("35_50")) increases r(MGI:"chitinase-like 1") |
| pubmed:25681350 | p(MGI:"myelin oligodendrocyte glycoprotein", frag("35_50")) increases path(EFO:"experimental autoimmune encephalomyelitis") |
| pubmed:25681350 | p(MGI:"myelin oligodendrocyte glycoprotein", frag("35_50")) increases r(MGI:"interleukin 1 alpha") |
| pubmed:25681350 | p(MGI:"myelin oligodendrocyte glycoprotein", frag("35_50")) increases r(MGI:"interleukin 6") |
| pubmed:30967783 | path(EFO:"experimental autoimmune encephalomyelitis") increases a(MESH:Monocytes, loc(GO:"node of Ranvier")) |
| pubmed:30967783 | path(EFO:"experimental autoimmune encephalomyelitis") increases a(MESH:Macrophages) |
| pubmed:25681350 | p(MGI:"interleukin 1 alpha") increases complex(GO:"NF-kappaB complex") |
| pubmed:25681350 | p(MGI:"interleukin 1 alpha") increases r(MGI:"chitinase-like 1") |
| pubmed:25681350 | p(MGI:"interleukin 1 alpha") regulates r(MGI:"chitinase-like 1") |
| pubmed:25681350 | p(MGI:"interleukin 1 alpha") increases r(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") |
| pubmed:25681350 | p(MGI:"interleukin 1 alpha") increases act(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")) |
| pubmed:25681350 | p(MGI:"interleukin 1 alpha") increases act(complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105"))) |
| pubmed:25681350 | p(MGI:"interleukin 1 alpha") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) |
| pubmed:25681350 | act(p(MGI:"interleukin 1 alpha")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) |
| pubmed:25681350 | p(MGI:"interleukin 1 alpha") increases path(MESH:Glioblastoma) |
| pubmed:25681350 | p(MGI:"interleukin 1 alpha") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) |
| pubmed:25681350 | p(MGI:"interleukin 1 alpha") increases act(p(MGI:"signal transducer and activator of transcription 3")) |
| pubmed:25681350 | p(MGI:"interleukin 1 alpha") increases p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases bp(MESH:"Synaptic Transmission") |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases bp(MESH:"Synaptic Transmission") |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Synaptic Transmission") |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death") |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") decreases bp(GO:"neuron death") |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") decreases bp(GO:"neuron death") |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death") |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death") |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases bp(GO:"positive regulation of synaptic plasticity") |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) increases bp(GO:"positive regulation of synaptic plasticity") |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") regulates bp(GO:cognition) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") regulates bp(GO:behavior) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases path(MESH:"Spatial Memory") |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) increases path(MESH:"Spatial Memory") |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases bp(GO:memory) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases bp(GO:learning) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases act(p(HGNC:PRKACA)) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") decreases p(HGNC:BCL2L1) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2L1) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") decreases tloc(a(PUBCHEM:16057918), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") regulates r(HGNC:BCL2L1) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") decreases bp(GO:"apoptotic process") |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") decreases bp(GO:"apoptotic process") |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex"), ma(GO:"DNA binding")) decreases bp(GO:"apoptotic process") |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"apoptotic process") |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2A1) |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) decreases act(a(MESH:"Amyloid beta-Peptides")) |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) increases r(HGNC:SOD2) |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) decreases p(MESH:Proteins, pmod(CONSO:nitration)) |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) increases bp(GO:neurogenesis) |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) increases bp(GO:neurogenesis) |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) increases bp(GO:neurogenesis) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") regulates a(MESH:"Neural Stem Cells") |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) negativeCorrelation a(MESH:"Cerebral Cortex") |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) increases bp(GO:"stem cell division") |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) |
| pubmed:25652642 | complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) increases bp(GO:"astrocyte development") |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:LIF) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:CNTF) |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) increases bp(GO:"dendritic spine organization") |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) increases a(GO:axon) |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) increases bp(GO:"axon guidance") |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") regulates r(HGNC:ITGB1) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:NCAM1) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:SLITRK1) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:GFRA1) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:TIAM1) |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) increases a(MESH:"Dendritic Cells") |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) increases a(GO:"dendritic branch") |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) increases r(HGNC:HES1) |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) increases r(HGNC:HES5) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:MAP1B) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:MAP2) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:C3) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:CFB) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:CR2) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:C4A) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:C4BPA) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:IL1B) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:IL1B) |
| pubmed:25652642 | complex(GO:"NF-kappaB complex") increases p(HGNC:IL1B) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases act(p(HGNC:IL1A)) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases act(complex(p(HGNC:CDK5), p(HGNC:CDK5R1))) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:TNF) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:TNF) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:TNF) |
| pubmed:25652642 | complex(GO:"NF-kappaB complex") increases p(HGNC:TNF) |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) increases tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) increases a(CHEBI:amyloid-beta) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") regulates a(CHEBI:amyloid-beta) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") regulates a(CHEBI:amyloid-beta) |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) regulates a(CHEBI:amyloid-beta) |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases r(HGNC:BACE1) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases r(HGNC:BACE1) |
| pubmed:21958873 | complex(GO:"NF-kappaB complex") regulates r(HGNC:BACE1) |
| pubmed:25331948 | complex(GO:"NF-kappaB complex") regulates r(HGNC:BACE1) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") regulates bp(CONSO:"APP processing") |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) decreases bp(CONSO:"APP processing") |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) positiveCorrelation bp(CONSO:"APP processing") |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") regulates p(CONSO:C99) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") regulates act(complex(GO:"gamma-secretase complex")) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases act(complex(GO:"gamma-secretase complex")) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:PSEN1) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:APP) |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:APP) |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) regulates p(HGNC:APP) |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) increases p(HGNC:SOD2) |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:SOD2)) |
| pubmed:28745240 | act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"calcium ion homeostasis") |
| pubmed:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:CXCL8) |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) increases bp(GO:"inflammatory response") |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) increases a(MESH:"Free Radicals") |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pubmed:25652642 | complex(GO:"NF-kappaB complex") association path(MESH:"Plaque, Amyloid") |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) regulates p(HGNC:BACE1) |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) decreases p(HGNC:BACE1) |
| pubmed:25331948 | complex(GO:"NF-kappaB complex") regulates p(HGNC:BACE1) |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) decreases p(CONSO:sAPP-beta) |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) positiveCorrelation p(CONSO:sAPP-beta) |
| pubmed:25652642 | complex(GO:"NF-kappaB complex") association act(p(HGNC:APOE)) |
| pubmed:25652642 | complex(GO:"NF-kappaB complex") increases bp(MESH:Neuroprotection) |
| pubmed:25652642 | complex(GO:"NF-kappaB complex") regulates bp(MESH:Neuroprotection) |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) decreases a(CHEBI:peroxynitrite) |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"membrane depolarization") |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) decreases a(MESH:"Cholinergic Neurons") |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25652642 | complex(GO:"NF-kappaB complex") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25652642 | complex(GO:"NF-kappaB complex") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) increases act(a(MESH:Microglia)) |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) increases act(a(MESH:Cytokines)) |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"glutamate(1-)")) |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"reactive oxygen species")) |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"reactive oxygen species")) |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:NOS2)) |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:NOS2)) |
| pubmed:25652642 | act(complex(GO:"NF-kappaB complex")) increases path(CONSO:neurotoxicity) |
| pubmed:25652642 | complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR9-1) |
| pubmed:25652642 | complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR34A) |
| pubmed:25652642 | complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR125B1) |
| pubmed:25652642 | complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR146A) |
| pubmed:25652642 | complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR155) |
| pubmed:25652642 | complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR339) |
| pubmed:21958873 | complex(GO:"NF-kappaB complex") regulates p(HGNC:CRP) |
| pubmed:25681350 | p(MGI:"oncostatin M") increases p(MGI:"signal transducer and activator of transcription 3") |
| pubmed:25681350 | p(MGI:"oncostatin M") increases act(p(MGI:"signal transducer and activator of transcription 3")) |
| pubmed:25681350 | p(MGI:"oncostatin M") increases act(p(MGI:"signal transducer and activator of transcription 3")) |
| pubmed:25681350 | p(MGI:"oncostatin M") increases r(MGI:"chitinase-like 1") |
| pubmed:25681350 | p(MGI:"oncostatin M") regulates r(MGI:"chitinase-like 1") |
| pubmed:25681350 | p(MGI:"oncostatin M") increases r(MGI:"chitinase-like 1") |
| pubmed:25681350 | p(MGI:"oncostatin M") increases path(MESH:Glioblastoma) |
| pubmed:25681350 | p(MGI:"oncostatin M") increases complex(p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) |
| pubmed:25681350 | p(MGI:"oncostatin M") increases act(p(MGI:"interleukin 1 alpha")) |
| pubmed:25681350 | p(MGI:"oncostatin M") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) |
| pubmed:25681350 | p(MGI:"signal transducer and activator of transcription 3") association p(MGI:"chitinase-like 1") |
| pubmed:25681350 | p(MGI:"signal transducer and activator of transcription 3") increases r(MGI:"chitinase-like 1") |
| pubmed:25681350 | p(MGI:"signal transducer and activator of transcription 3") increases r(MGI:"chitinase-like 1") |
| pubmed:25681350 | act(p(MGI:"signal transducer and activator of transcription 3")) increases act(p(MGI:"interleukin 1 alpha")) |
| pubmed:25681350 | act(p(MGI:"signal transducer and activator of transcription 3")) increases act(p(MGI:"oncostatin M")) |
| pubmed:25681350 | p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") association p(MGI:"chitinase-like 1") |
| pubmed:25681350 | p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") causesNoChange p(MGI:"chitinase-like 1") |
| pubmed:25681350 | p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") decreases r(MGI:"chemokine (C-X-C motif) ligand 15") |
| pubmed:25681350 | p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") causesNoChange r(MGI:"chitinase-like 1") |
| pubmed:25681350 | p(MGI:"chitinase-like 1") association p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") |
| pubmed:25681350 | p(MGI:"chitinase-like 1") association p(MGI:"signal transducer and activator of transcription 3") |
| pubmed:25681350 | p(MGI:"chitinase-like 1") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) |
| pubmed:25681350 | p(MGI:"chitinase-like 1") increases complex(a(GO:"NF-kappaB p50/p65 complex"), p(MGI:"chitinase-like 1")) |
| pubmed:25681350 | p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha", var("?")) decreases act(p(MGI:"interleukin 1 alpha")) |
| pubmed:25681350 | p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha", var("?")) decreases act(p(MGI:"oncostatin M")) |
| pubmed:25681350 | p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases r(MGI:"chitinase-like 1") |
| pubmed:25681350 | p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") regulates p(MGI:"chitinase-like 1") |
| pubmed:25681350 | p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") regulates p(MGI:"chitinase-like 1") |
| pubmed:25681350 | p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases p(MGI:"chitinase-like 1") |
| pubmed:25681350 | p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases act(p(MGI:"interleukin 1 alpha")) |
| pubmed:25681350 | p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases act(p(MGI:"oncostatin M")) |
| pubmed:25681350 | p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") increases r(MGI:"chitinase-like 1") |
| pubmed:25681350 | p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") regulates p(MGI:"chitinase-like 1") |
| pubmed:25681350 | p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") increases act(p(MGI:"interleukin 1 alpha")) |
| pubmed:25681350 | p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") increases act(p(MGI:"oncostatin M")) |
| pubmed:25681350 | p(MGI:"reticuloendotheliosis oncogene") causesNoChange p(MGI:"chitinase-like 1") |
| pubmed:25681350 | p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100") causesNoChange p(MGI:"chitinase-like 1") |
| pubmed:25681350 | p(HGNC:IL1A) increases p(HGNC:RELB) |
| pubmed:25681350 | p(HGNC:IL1A) causesNoChange r(HGNC:CHI3L1) |
| pubmed:25681350 | p(HGNC:IL1A) causesNoChange r(HGNC:RELB) |
| pubmed:28745240 | act(p(HGNC:IL1A)) increases bp(GO:"p38MAPK cascade") |
| pubmed:27794524 | p(HGNC:IL1A) directlyDecreases a(MESH:Oligodendroglia) |
| pubmed:30967783 | p(HGNC:IL1A) increases path(MESH:Inflammation) |
| pubmed:23702978 | p(HGNC:IL1A) increases act(p(HGNC:IL1R1)) |
| pubmed:23702978 | p(HGNC:IL1A) increases bp(GO:"inflammatory response") |
| pubmed:25681350 | p(HGNC:RELB) causesNoChange p(HGNC:CHI3L1) |
| pubmed:25681350 | p(MGI:"tumor necrosis factor") increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:25681350 | p(MGI:"tumor necrosis factor") regulates r(MGI:"chitinase-like 1") |
| pubmed:25681350 | p(MGI:"tumor necrosis factor") increases act(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")) |
| pubmed:25681350 | p(MGI:"tumor necrosis factor") increases act(complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105"))) |
| pubmed:25681350 | complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) regulates r(MGI:"chitinase-like 1") |
| pubmed:25681350 | complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) increases r(MGI:"chitinase-like 1") |
| pubmed:25681350 | complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) |
| pubmed:25681350 | complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) |
| pubmed:21718217 | r(HGNC:CHI3L1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25681350 | p(HGNC:OSM) causesNoChange r(HGNC:CHI3L1) |
| pubmed:25681350 | p(HGNC:OSM) causesNoChange r(HGNC:RELB) |
| pubmed:25024322 | p(HGNC:CHI3L1) positiveCorrelation p(HGNC:MAPT) |
| pubmed:25865441 | p(HGNC:CHI3L1) positiveCorrelation p(HGNC:MAPT) |
| pubmed:25865441 | p(HGNC:CHI3L1) positiveCorrelation p(HGNC:MAPT) |
| pubmed:26836182 | p(HGNC:CHI3L1) positiveCorrelation p(HGNC:MAPT) |
| pubmed:26836182 | p(HGNC:CHI3L1) positiveCorrelation p(HGNC:MAPT) |
| pubmed:25024322 | p(HGNC:CHI3L1) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25865441 | p(HGNC:CHI3L1) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25865441 | p(HGNC:CHI3L1) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25024322 | p(HGNC:CHI3L1) positiveCorrelation a(CONSO:"CDR - Sum of Boxes") |
| pubmed:25024322 | p(HGNC:CHI3L1) positiveCorrelation a(NIFT:"Free and Cued Selective Reminding Test") |
| pubmed:25024322 | p(HGNC:CHI3L1) positiveCorrelation a(CONSO:"Mini-Mental Status Exam") |
| pubmed:25865441 | p(HGNC:CHI3L1) biomarkerFor path(MESH:Inflammation) |
| pubmed:26979166 | p(HGNC:CHI3L1) association path(MESH:Inflammation) |
| pubmed:25865441 | p(HGNC:CHI3L1) negativeCorrelation a(NIFT:"Cortical Thickness") |
| pubmed:25865441 | p(HGNC:CHI3L1) negativeCorrelation a(NIFT:"Cortical Thickness") |
| pubmed:26836182 | p(HGNC:CHI3L1) negativeCorrelation a(NIFT:"Cortical Thickness") |
| pubmed:25865441 | p(HGNC:CHI3L1) increases bp(GO:"inflammatory response") |
| pubmed:26836182 | p(HGNC:CHI3L1) positiveCorrelation p(HGNC:NEFL) |
| pubmed:26836182 | p(HGNC:CHI3L1) increases p(HGNC:NEFL) |
| pubmed:26836182 | p(HGNC:CHI3L1) positiveCorrelation path(CONSO:neuroinflammation) |
| pubmed:25681350 | p(HGNC:RELA) causesNoChange p(HGNC:CHI3L1) |
| pubmed:21329555 | p(HGNC:RELA) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25652642 | p(HGNC:RELA, loc(GO:nucleus)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21329555 | p(HGNC:RELA) increases r(HGNC:BACE1) |
| pubmed:21329555 | p(HGNC:RELA) increases p(HGNC:BACE1) |
| pubmed:21329555 | p(HGNC:RELA) increases p(CONSO:C99) |
| pubmed:21329555 | p(HGNC:RELA) causesNoChange p(HGNC:APP) |
| pubmed:21329555 | p(HGNC:RELA) increases a(CHEBI:amyloid-beta) |
| pubmed:28745240 | p(HGNC:RELA) increases bp(MESH:"Synaptic Transmission") |
| pubmed:28745240 | p(HGNC:RELA) increases bp(GO:"long-term synaptic potentiation") |
| pubmed:28745240 | p(HGNC:RELA) negativeCorrelation bp(GO:"apoptotic process") |
| pubmed:27288790 | act(p(HGNC:RELA)) increases bp(GO:"apoptotic process") |
| pubmed:27288790 | p(HGNC:RELA) decreases bp(GO:"neuron apoptotic process") |
| pubmed:26551702 | p(HGNC:RELA) increases p(HGNC:KEAP1, loc(MESH:"Cell Nucleus")) |
| pubmed:26551702 | act(p(HGNC:RELA)) decreases act(p(HGNC:NFE2L2)) |
| pubmed:26551702 | act(p(HGNC:RELA)) decreases act(complex(p(HGNC:CREBBP), p(HGNC:EP300))) |
| pubmed:26551702 | p(HGNC:RELA) decreases complex(p(HGNC:CREBBP), p(HGNC:NFE2L2)) |
| pubmed:26551702 | p(HGNC:RELA) increases act(p(FPLX:NFkappaB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:25681350 | path(MESH:Glioblastoma) increases p(MGI:"chitinase-like 1") |
| pubmed:25681350 | path(MESH:Glioblastoma) increases p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") |
| pubmed:25681350 | complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) increases r(MGI:"chitinase-like 1") |
| pubmed:25681350 | composite(p(MGI:"interleukin 1 alpha"), p(MGI:"oncostatin M")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) |
| pubmed:21329555 | complex(g(HGNC:BACE1), p(FPLX:NFkappaB)) regulates r(HGNC:BACE1) |
| pubmed:21329555 | act(p(FPLX:NFkappaB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases r(HGNC:BACE1) |
| pubmed:29179999 | act(p(FPLX:NFkappaB)) association r(HGNC:BACE1) |
| pubmed:29179999 | act(p(FPLX:NFkappaB)) association bp(GO:"inflammatory response") |
| pubmed:29179999 | tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) increases bp(GO:"inflammatory response") |
| pubmed:27288790 | p(FPLX:NFkappaB) regulates bp(GO:"inflammatory response") |
| pubmed:26551702 | act(p(FPLX:NFkappaB)) increases bp(GO:"inflammatory response") |
| pubmed:29179999 | p(FPLX:NFkappaB) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27288790 | act(p(FPLX:NFkappaB)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29179999 | act(p(FPLX:NFkappaB)) association path(HP:Neurodegeneration) |
| pubmed:29179999 | act(p(FPLX:NFkappaB)) regulates p(FPLX:"NADPH_oxidase") |
| pubmed:26551702 | p(FPLX:NFkappaB) increases p(FPLX:"NADPH_oxidase") |
| pubmed:29179999 | act(p(FPLX:NFkappaB)) regulates p(HGNC:PTGS2) |
| pubmed:27288790 | p(FPLX:NFkappaB) increases p(HGNC:PTGS2) |
| pubmed:29179999 | act(p(FPLX:NFkappaB)) regulates a(MESH:Interleukins) |
| pubmed:29179999 | act(p(FPLX:NFkappaB)) regulates p(FPLX:SOD) |
| pubmed:29179999 | act(p(FPLX:NFkappaB)) association r(HGNC:NLRP3) |
| pubmed:27288790 | p(FPLX:NFkappaB) association path(MESH:Inflammation) |
| pubmed:26551702 | p(FPLX:NFkappaB) regulates path(MESH:Inflammation) |
| pubmed:27288790 | p(FPLX:NFkappaB) association bp(GO:"negative regulation of neuron apoptotic process") |
| pubmed:27288790 | p(FPLX:NFkappaB) association bp(GO:"neuron differentiation") |
| pubmed:27288790 | p(FPLX:NFkappaB) association bp(GO:"apoptotic process") |
| pubmed:27288790 | p(FPLX:NFkappaB) association bp(MESH:"Neuronal Outgrowth") |
| pubmed:27288790 | p(FPLX:NFkappaB) association bp(GO:"regulation of synaptic plasticity") |
| pubmed:27288790 | act(p(FPLX:NFkappaB)) increases r(HGNC:IL1B) |
| pubmed:27288790 | act(p(FPLX:NFkappaB)) increases r(HGNC:TNF) |
| pubmed:27288790 | act(p(FPLX:NFkappaB)) decreases p(HGNC:UCHL1) |
| pubmed:27288790 | p(FPLX:NFkappaB) regulates act(p(HGNC:NOS2)) |
| pubmed:27288790 | act(p(FPLX:NFkappaB)) increases a(MESH:Cytokines) |
| pubmed:26551702 | act(p(FPLX:NFkappaB)) increases a(MESH:Cytokines) |
| pubmed:27288790 | act(p(FPLX:NFkappaB)) increases a(MESH:Chemokines) |
| pubmed:27288790 | p(FPLX:NFkappaB) increases m(MIRBASE:hsa-mir-125b-1) |
| pubmed:27288790 | p(FPLX:NFkappaB) increases m(MIRBASE:hsa-mir-125b-2) |
| pubmed:27288790 | p(FPLX:NFkappaB) increases m(MIRBASE:hsa-mir-146a) |
| pubmed:27288790 | p(FPLX:NFkappaB) increases m(MIRBASE:hsa-mir-155) |
| pubmed:27288790 | act(p(FPLX:NFkappaB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases m(MIRBASE:hsa-mir-155) |
| pubmed:26551702 | p(FPLX:NFkappaB) regulates bp(GO:"immune response") |
| pubmed:26551702 | p(FPLX:NFkappaB) regulates bp(GO:"developmental process") |
| pubmed:26551702 | p(FPLX:NFkappaB) regulates bp(GO:"cell population proliferation") |
| pubmed:26551702 | p(FPLX:NFkappaB) regulates bp(GO:"UV protection") |
| pubmed:26551702 | p(FPLX:NFkappaB) increases act(a(MESH:Mitochondria)) |
| pubmed:26551702 | act(p(FPLX:NFkappaB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates bp(MESH:"Antioxidant Response Elements") |
| pubmed:26551702 | act(p(FPLX:NFkappaB)) increases p(HGNC:NFE2L2) |
| pubmed:30640040 | p(FPLX:NFkappaB) association a(PUBCHEM:5318517) |
| pubmed:26118667 | p(FPLX:NFkappaB) increases complex(g(MIRBASE:rno-mir-195), p(FPLX:NFkappaB)) |
| pubmed:21329555 | complex(g(HGNC:BACE1), p(HGNC:RELA)) increases r(HGNC:BACE1) |
| pubmed:21329555 | r(HGNC:NFKBIA) decreases a(CHEBI:amyloid-beta) |
| pubmed:21329555 | bp(GO:"NIK/NF-kappaB signaling") association path(MESH:Inflammation) |
| pubmed:21329555 | bp(GO:"NIK/NF-kappaB signaling") association path(MESH:"Oxidative Stress") |
| pubmed:21329555 | path(MESH:"Oxidative Stress") association bp(GO:"NIK/NF-kappaB signaling") |
| pubmed:30962309 | path(MESH:"Oxidative Stress") increases a(CHEBI:"reactive oxygen species") |
| pubmed:27794524 | path(MESH:"Oxidative Stress") association bp(GO:"neuron death") |
| pubmed:27794524 | path(MESH:"Oxidative Stress") negativeCorrelation bp(GO:"myelin maintenance") |
| pubmed:27956442 | path(MESH:"Oxidative Stress") directlyIncreases path(MESH:Inflammation) |
| pubmed:27956442 | path(MESH:"Oxidative Stress") increases path(MESH:"Amnesia, Anterograde") |
| pubmed:27956442 | path(MESH:"Oxidative Stress") increases path(MESH:"Amnesia, Retrograde") |
| pubmed:23516100 | path(MESH:"Oxidative Stress") association p(MESH:Proteins, frag("?")) |
| pubmed:30688256 | path(MESH:"Oxidative Stress") increases bp(GO:mitophagy) |
| pubmed:30688256 | path(MESH:"Oxidative Stress") increases path(MESH:"Parkinson Disease") |
| pubmed:30012004 | path(MESH:"Oxidative Stress") positiveCorrelation path(MESH:"Huntington Disease") |
| pubmed:26968346 | path(MESH:"Oxidative Stress") decreases p(HGNCGENEFAMILY:"MTOR complex 1") |
| pubmed:26968346 | path(MESH:"Oxidative Stress") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:30837838 | path(MESH:"Oxidative Stress") increases p(HGNC:TARDBP, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30837838 | path(MESH:"Oxidative Stress") increases p(CONSO:"TDP-43 aggregates") |
| pubmed:30837838 | path(MESH:"Oxidative Stress") association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | path(MESH:"Oxidative Stress") increases bp(GO:"peptidyl-cysteine oxidation") |
| pubmed:21329555 | p(HGNC:TNF) increases bp(GO:"NIK/NF-kappaB signaling") |
| pubmed:21329555 | p(HGNC:TNF) increases r(HGNC:BACE1) |
| pubmed:21329555 | p(HGNC:TNF) increases r(HGNC:BACE1) |
| pubmed:21958873 | p(HGNC:TNF) increases r(HGNC:BACE1) |
| pubmed:25331948 | p(HGNC:TNF) increases r(HGNC:BACE1) |
| pubmed:21329555 | p(HGNC:TNF) increases act(p(FPLX:NFkappaB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:29179999 | p(HGNC:TNF) increases act(p(FPLX:NFkappaB)) |
| pubmed:27288790 | p(HGNC:TNF) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pubmed:27288790 | p(HGNC:TNF) increases act(p(FPLX:NFkappaB)) |
| pubmed:26551702 | p(HGNC:TNF) increases act(p(FPLX:NFkappaB)) |
| pubmed:28745240 | p(HGNC:TNF) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:21958873 | p(HGNC:TNF) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:25331948 | p(HGNC:TNF) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | p(HGNC:TNF) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27288790 | p(HGNC:TNF) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25652642 | p(HGNC:TNF) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:28745240 | p(HGNC:TNF) increases path(CONSO:neurotoxicity) |
| pubmed:28745240 | p(HGNC:TNF) increases bp(GO:"neuron death") |
| pubmed:27288790 | p(HGNC:TNF) increases p(FPLX:"IKK_complex", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27288790 | p(HGNC:TNF) increases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | p(HGNC:TNF) increases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | p(HGNC:TNF) increases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | p(HGNC:TNF) increases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27288790 | p(HGNC:TNF) decreases p(FPLX:IKB) |
| pubmed:27288790 | p(HGNC:TNF) increases a(MESH:Cytokines) |
| pubmed:27794524 | p(HGNC:TNF) isA a(MESH:Cytokines) |
| pubmed:27288790 | p(HGNC:TNF) increases a(MESH:Chemokines) |
| pubmed:27288790 | p(HGNC:TNF) increases act(p(HGNC:BACE1)) |
| pubmed:25331948 | p(HGNC:TNF) increases p(HGNC:BACE1) |
| pubmed:27288790 | p(HGNC:TNF) increases act(p(FPLX:ERK)) |
| pubmed:27288790 | p(HGNC:TNF) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25652642 | p(HGNC:TNF) increases p(HGNC:NGF) |
| pubmed:25652642 | p(HGNC:TNF) increases p(HGNC:BCL2) |
| pubmed:26551702 | p(HGNC:TNF) increases act(p(HGNC:NFE2L2), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:30962309 | p(HGNC:TNF) increases bp(GO:"cell death") |
| pubmed:27794524 | p(HGNC:TNF) positiveCorrelation path(MESH:"Complement Activation") |
| pubmed:27794524 | p(HGNC:TNF) positiveCorrelation act(p(MESH:T-Lymphocytes)) |
| pubmed:27794524 | p(HGNC:TNF) directlyDecreases a(MESH:Oligodendroglia) |
| pubmed:26445701 | p(HGNC:TNF) regulates path(MESH:Inflammation) |
| pubmed:30967783 | p(HGNC:TNF) increases path(MESH:Inflammation) |
| pubmed:26979166 | tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases path(MESH:Inflammation) |
| pubmed:26979166 | p(HGNC:TNF) increases path(MESH:Inflammation) |
| pubmed:26445701 | p(HGNC:TNF) increases path(HP:"CNS demyelination") |
| pubmed:26445701 | p(HGNC:TNF) increases path(MESH:"Diffuse Axonal Injury") |
| pubmed:26445701 | p(HGNC:TNF) increases bp(GO:"positive regulation of oligodendrocyte apoptotic process") |
| pubmed:30967783 | p(HGNC:TNF) increases a(CHEBI:"2 L-glutamate") |
| pubmed:30967783 | p(HGNC:TNF) negativeCorrelation act(a(MESH:Astrocytes)) |
| pubmed:30967783 | p(HGNC:TNF) increases bp(MESH:Neuroprotection) |
| pubmed:19126755 | p(HGNC:TNF) increases bp(GO:"MAPK cascade") |
| pubmed:19293145 | p(HGNC:TNF) increases act(a(CHEBI:nicotine)) |
| pubmed:19293145 | p(HGNC:TNF) decreases act(a(CHEBI:"N-methyl-D-aspartic acid")) |
| pubmed:23178521 | p(HGNC:TNF) causesNoChange p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | p(HGNC:TNF) increases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | p(HGNC:TNF) increases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25331948 | p(HGNC:TNF) increases a(MESH:"Amyloid beta-Peptides") |
| pubmed:30988501 | p(HGNC:TNF) increases bp(GO:"regulation of action potential firing rate") |
| pubmed:30988501 | p(HGNC:TNF) increases a(MESH:"Neural Pathways") |
| pubmed:30988501 | p(HGNC:TNF) increases act(a(MESH:Microglia)) |
| pubmed:30988501 | p(HGNC:TNF) increases a(MESH:"Synaptic Membranes") |
| pubmed:21329555 | a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases r(HGNC:BACE1) |
| pubmed:27288790 | a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases act(p(HGNC:BACE1)) |
| pubmed:19126755 | a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases act(p(HGNC:PTGS1)) |
| pubmed:19126755 | a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases act(p(HGNC:PTGS2)) |
| pubmed:21329555 | a(CHEBI:ibuprofen) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") |
| pubmed:27288790 | a(CHEBI:ibuprofen) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") |
| pubmed:21329555 | a(CHEBI:ibuprofen) decreases r(HGNC:BACE1) |
| pubmed:27288790 | a(CHEBI:ibuprofen) decreases r(HGNC:BACE1) |
| pubmed:27288790 | a(CHEBI:ibuprofen) decreases a(CHEBI:amyloid-beta) |
| pubmed:21329555 | a(PUBCHEM:3715) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") |
| pubmed:21329555 | a(PUBCHEM:3715) decreases r(HGNC:BACE1) |
| pubmed:28745240 | p(HGNC:SYP) increases complex(p(HGNC:NFKB1), p(HGNC:RELA), p(HGNC:SYP)) |
| pubmed:26813123 | p(HGNC:SYP) association bp(GO:memory) |
| pubmed:28745240 | p(HGNC:NFKB1) increases bp(GO:"long-term synaptic potentiation") |
| pubmed:28745240 | p(HGNC:NFKB1) increases path(MESH:"Spatial Memory") |
| pubmed:28745240 | p(HGNC:NFKB1) increases bp(GO:learning) |
| pubmed:28745240 | p(HGNC:NFKB1) increases path(MESH:Anxiety) |
| pubmed:27288790 | act(p(HGNC:NFKB1)) increases bp(GO:"apoptotic process") |
| pubmed:30988501 | p(HGNC:NFKB1) increases a(MESH:Cytokines) |
| pubmed:23702978 | p(HGNC:NFKB1) increases p(HGNC:IL1B) |
| pubmed:28745240 | a(GO:synapse) association complex(p(HGNC:NFKB1), p(HGNC:RELA)) |
| pubmed:30967783 | a(GO:synapse) increases bp(GO:"learning or memory") |
| pubmed:30967783 | a(GO:synapse) increases bp(GO:"learning or memory") |
| pubmed:30061532 | act(a(GO:synapse)) association path(CONSO:Neurodegeneration) |
| pubmed:30061532 | a(GO:synapse) association p(HGNC:DISC1) |
| pubmed:30515821 | act(a(GO:synapse)) positiveCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:26813123 | a(GO:synapse) negativeCorrelation path(MESH:"Cognitive Dysfunction") |
| pubmed:25514383 | a(GO:synapse) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | act(a(GO:synapse)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | act(a(GO:synapse)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:28445721 | act(a(GO:synapse)) regulates p(FPLX:CHRN) |
| pubmed:30106381 | act(a(GO:synapse)) association p(HGNC:ADNP) |
| pubmed:30106381 | act(a(GO:synapse)) association a(PUBCHEM:9832404) |
| pubmed:22908190 | act(a(GO:synapse)) positiveCorrelation bp(GO:cognition) |
| pubmed:22908190 | act(a(GO:synapse)) decreases path(MESH:"Plaque, Amyloid") |
| pubmed:22908190 | act(a(GO:synapse)) positiveCorrelation bp(GO:endocytosis) |
| pubmed:22908190 | act(a(GO:synapse)) positiveCorrelation p(HGNC:CTSB) |
| pubmed:26631930 | act(a(GO:synapse)) increases tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:"excitatory synapse")) |
| pubmed:26631930 | act(a(GO:synapse)) negativeCorrelation p(HGNC:MAPT) |
| pubmed:27796283 | act(a(GO:synapse)) negativeCorrelation act(p(HGNC:RHOA)) |
| pubmed:27796283 | a(GO:synapse) regulates p(HGNC:CAMKV) |
| pubmed:22156579 | a(GO:synapse) negativeCorrelation p(HGNC:MARK4) |
| pubmed:28745240 | complex(p(HGNC:NFKB1), p(HGNC:RELA)) association a(GO:synapse) |
| pubmed:28745240 | complex(p(HGNC:NFKB1), p(HGNC:RELA)) increases complex(p(HGNC:BACE1), p(HGNC:NFKB1), p(HGNC:RELA)) |
| pubmed:25652642 | act(complex(p(HGNC:NFKB1), p(HGNC:RELA))) increases bp(GO:"apoptotic process") |
| pubmed:21214928 | bp(MESH:"Synaptic Transmission") association a(CHEBI:amyloid-beta) |
| pubmed:26813123 | bp(MESH:"Synaptic Transmission") association bp(GO:memory) |
| pubmed:14556719 | bp(MESH:"Synaptic Transmission") association p(HGNC:PRKN) |
| pubmed:28745240 | p(HGNC:REL) increases bp(GO:"long-term synaptic depression") |
| pubmed:28745240 | bp(GO:"long-term synaptic depression") decreases p(HGNC:NFKB1) |
| pubmed:28745240 | bp(GO:"long-term synaptic depression") decreases p(HGNC:RELA) |
| pubmed:27041503 | bp(GO:"long-term synaptic depression") decreases bp(GO:"regulation of synaptic plasticity") |
| pubmed:21871088 | bp(GO:"long-term synaptic depression") association bp(GO:"calcium ion import") |
| pubmed:21871088 | bp(GO:"long-term synaptic depression") association bp(GO:"cellular calcium ion homeostasis") |
| pubmed:22908190 | bp(GO:"long-term synaptic depression") negativeCorrelation act(p(HGNC:RAB5A)) |
| pubmed:26631930 | bp(GO:"long-term synaptic depression") association p(HGNC:MAPT) |
| pubmed:28745240 | path(MESH:"Spatial Memory") association bp(GO:"long-term synaptic potentiation") |
| pubmed:28745240 | a(CHEBI:"glutamate(1-)") increases act(a(GO:"excitatory synapse")) |
| pubmed:28745240 | a(CHEBI:"glutamate(1-)") increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | a(CHEBI:"glutamate(1-)") increases path(CONSO:Excitotoxicity) |
| pubmed:25652642 | a(CHEBI:"glutamate(1-)") increases act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) |
| pubmed:25652642 | a(CHEBI:"glutamate(1-)") increases act(complex(p(HGNC:NFKB1), p(HGNC:RELA))) |
| pubmed:16273023 | a(CHEBI:"glutamate(1-)") association path(MESH:D013850) |
| pubmed:16273023 | a(CHEBI:"glutamate(1-)") association path(MESH:D008568) |
| pubmed:27087442 | a(CHEBI:"glutamate(1-)") increases p(CONSO:"CDK5R1 p25") |
| pubmed:28745240 | act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | path(CONSO:Excitotoxicity) increases bp(GO:"neuron death") |
| pubmed:19419557 | path(CONSO:Excitotoxicity) increases bp(GO:"neuron apoptotic process") |
| pubmed:30012004 | path(CONSO:Excitotoxicity) positiveCorrelation path(MESH:"Huntington Disease") |
| pubmed:30027901 | path(CONSO:Excitotoxicity) association path(MESH:"Huntington Disease") |
| pubmed:21722302 | path(CONSO:Excitotoxicity) increases bp(GO:"motor neuron apoptotic process") |
| pubmed:24027553 | path(CONSO:Excitotoxicity) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) |
| pubmed:24027553 | path(CONSO:Excitotoxicity) association act(p(HGNCGENEFAMILY:Calpains)) |
| pubmed:27607061 | path(CONSO:Excitotoxicity) negativeCorrelation tloc(p(HGNC:GRIK2), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) |
| pubmed:28745240 | a(MESH:"Receptors, N-Methyl-D-Aspartate") regulates bp(GO:"calcium ion import") |
| pubmed:28745240 | a(MESH:"Receptors, N-Methyl-D-Aspartate") regulates act(p(HGNC:CAMK2A)) |
| pubmed:25652642 | a(MESH:"Receptors, N-Methyl-D-Aspartate") increases act(complex(p(HGNC:NFKB1), p(HGNC:RELA))) |
| pubmed:21214928 | a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(CONSO:CONSO00064) |
| pubmed:22122372 | a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(CONSO:CONSO00064) |
| pubmed:21214928 | a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(CONSO:CONSO00065) |
| pubmed:22122372 | a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(CONSO:CONSO00065) |
| pubmed:21214928 | a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(CHEBI:amyloid-beta) |
| pubmed:22122372 | a(MESH:"Receptors, N-Methyl-D-Aspartate") decreases p(CONSO:CONSO00063) |
| pubmed:25514383 | a(MESH:"Receptors, N-Methyl-D-Aspartate") regulates tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:24653673 | a(MESH:"Receptors, N-Methyl-D-Aspartate") association path(MESH:"Alzheimer Disease") |
| pubmed:26751493 | a(MESH:"Receptors, N-Methyl-D-Aspartate") association p(CONSO:"projection domain") |
| pubmed:27796283 | a(MESH:"Receptors, N-Methyl-D-Aspartate") increases act(p(HGNC:RAC1)) |
| pubmed:27796283 | a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HGNC:TIAM1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22833681 | act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases p(CONSO:"Tau epitope, AT8") |
| pubmed:22833681 | act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases p(CONSO:"Tau epitope, PHF1") |
| pubmed:22833681 | act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases p(CONSO:"Tau epitope, AT180") |
| pubmed:22833681 | act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) decreases p(CONSO:"Tau epitope, AT100") |
| pubmed:22833681 | act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) positiveCorrelation path(CONSO:"Long-Term Depression") |
| pubmed:22833681 | act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) |
| pubmed:28745240 | bp(GO:"calcium ion import") increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | bp(GO:"calcium ion import") increases act(p(HGNC:CAMK2A)) |
| pubmed:28745240 | bp(GO:"calcium ion import") increases act(p(FPLX:PKC)) |
| pubmed:28745240 | bp(GO:"calcium ion import") increases act(complex(GO:"phosphatidylinositol 3-kinase complex")) |
| pubmed:28745240 | bp(GO:"calcium ion import") increases act(p(FPLX:AKT)) |
| pubmed:27794524 | bp(GO:"calcium ion import") increases path(MESH:"Energy Metabolism") |
| pubmed:19419557 | bp(GO:"calcium ion import") increases a(CHEBI:amyloid-beta) |
| pubmed:19419557 | bp(GO:"calcium ion import") association p(HGNC:CALHM1) |
| pubmed:21871088 | bp(GO:"calcium ion import") increases bp(GO:"long-term synaptic depression") |
| pubmed:21871088 | bp(GO:"calcium ion import") association bp(GO:"long-term synaptic depression") |
| pubmed:21871088 | bp(GO:"calcium ion import") association bp(GO:"long-term synaptic potentiation") |
| pubmed:26813123 | bp(GO:"calcium ion import") regulates act(p(HGNC:CHAT)) |
| pubmed:26979166 | bp(GO:"calcium ion import") increases tloc(a(CHEBI:neurotransmitter), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28745240 | act(p(HGNC:CAMK2A)) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | act(p(HGNC:CAMK2A)) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | act(p(HGNC:CAMK2A)) increases act(complex(GO:"IkappaB kinase complex")) |
| pubmed:28745240 | act(p(HGNC:CAMK2A)) increases p(MESH:"I-kappa B Kinase", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29661268 | act(p(HGNC:CAMK2A), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26631930 | p(HGNC:CAMK2A) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22122372 | p(HGNC:CAMK2A) increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 654)) |
| pubmed:22122372 | p(HGNC:CAMK2A) increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) |
| pubmed:22122372 | p(HGNC:CAMK2A) increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Ser, 665)) |
| pubmed:29428175 | p(HGNC:CAMK2A) regulates a(GO:cytoskeleton) |
| pubmed:26631930 | p(HGNC:CAMK2A) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:17493042 | p(HGNC:CAMK2A) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser)) |
| pubmed:28745240 | act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:25652642 | act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | act(p(FPLX:PKC)) increases act(complex(GO:"IkappaB kinase complex")) |
| pubmed:28745240 | act(p(FPLX:PKC)) increases p(MESH:"I-kappa B Kinase", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29179999 | act(p(FPLX:PKC)) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pubmed:18650430 | p(FPLX:PKC) increases tloc(p(HGNC:APP), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:24590577 | act(p(FPLX:PKC)) increases tloc(p(HGNC:APP), fromLoc(GO:"Golgi apparatus"), toLoc(GO:"cell surface")) |
| pubmed:26813123 | p(FPLX:PKC) increases p(HGNC:SLC18A3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26813123 | p(FPLX:PKC) increases p(FPLX:CHRN, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24590577 | act(p(FPLX:PKC)) increases act(p(HGNC:ADAM10)) |
| pubmed:24590577 | act(p(FPLX:PKC)) increases p(HGNC:BACE1) |
| pubmed:24590577 | act(p(FPLX:PKC)) decreases act(p(HGNC:GSK3B)) |
| pubmed:17493042 | p(FPLX:PKC) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) |
| pubmed:28745240 | act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases act(complex(GO:"IkappaB kinase complex")) |
| pubmed:28745240 | act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases p(MESH:"I-kappa B Kinase", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28745240 | act(p(FPLX:AKT)) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | act(p(FPLX:AKT)) increases act(complex(GO:"IkappaB kinase complex")) |
| pubmed:28745240 | act(p(FPLX:AKT)) increases p(MESH:"I-kappa B Kinase", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27288790 | act(p(FPLX:AKT)) increases p(HGNC:RELA) |
| pubmed:30061532 | p(FPLX:AKT) regulates act(p(HGNC:MTOR)) |
| pubmed:30061532 | act(p(FPLX:AKT)) increases act(p(HGNC:MTOR)) |
| pubmed:19293145 | act(p(FPLX:AKT)) decreases bp(GO:"apoptotic process") |
| pubmed:23454242 | p(FPLX:AKT) regulates bp(GO:"apoptotic process") |
| pubmed:19293145 | p(FPLX:AKT) association bp(GO:"insulin receptor signaling pathway") |
| pubmed:25514383 | act(p(FPLX:AKT)) decreases bp(HP:Neurodegeneration) |
| pubmed:30697142 | p(FPLX:AKT) decreases bp(GO:"programmed cell death") |
| pubmed:30697142 | act(p(FPLX:AKT)) increases p(HGNC:CREBBP) |
| pubmed:30697142 | act(p(FPLX:AKT)) increases p(HGNC:BCL2) |
| pubmed:30697142 | act(p(FPLX:AKT)) increases p(HGNC:MAP3K5) |
| pubmed:30697142 | act(p(FPLX:AKT)) decreases act(p(HGNC:MAPK8)) |
| pubmed:30697142 | act(p(FPLX:AKT)) increases bp(MESH:Neuroprotection) |
| pubmed:30697142 | act(p(FPLX:AKT)) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:30697142 | act(p(FPLX:AKT)) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| doi:"10.4172/2168-975X.1000126" | p(FPLX:AKT) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:25331948 | p(FPLX:AKT) regulates p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:29121589 | p(FPLX:AKT) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:29844403 | p(FPLX:AKT) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:23454242 | p(FPLX:AKT) regulates bp(GO:"cell growth") |
| pubmed:23454242 | p(FPLX:AKT) regulates bp(GO:"cell population proliferation") |
| pubmed:29121589 | p(FPLX:AKT) positiveCorrelation p(HGNC:NFE2L2) |
| pubmed:29121589 | p(FPLX:AKT) regulates act(p(MGI:Gsk3b)) |
| pubmed:28745240 | act(complex(GO:"IkappaB kinase complex")) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | p(MESH:"I-kappa B Kinase", pmod(go:0006468 ! "protein phosphorylation")) increases act(complex(GO:"IkappaB kinase complex")) |
| pubmed:27889190 | bp(GO:behavior) association path(DOID:"acute disseminated encephalomyelitis") |
| pubmed:24511233 | bp(GO:behavior) association path(MESH:Schizophrenia) |
| pubmed:24511233 | bp(GO:behavior) association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:31248781 | bp(GO:behavior) positiveCorrelation p(MESH:"Amyloid beta-Peptides", frag("1_?")) |
| pubmed:23516100 | bp(GO:behavior) negativeCorrelation p(GO:"neurofibrillary tangle") |
| pubmed:26968346 | bp(GO:behavior) positiveCorrelation act(p(MESH:Glucosylceramidase)) |
| pubmed:26968346 | bp(GO:behavior) positiveCorrelation p(HGNC:TFEB) |
| pubmed:27299292 | bp(GO:behavior) positiveCorrelation p(HGNC:TFEB) |
| pubmed:27299292 | bp(GO:behavior) positiveCorrelation p(HGNC:TFEB) |
| pubmed:28420982 | bp(GO:behavior) association p(HGNC:MAPT) |
| pubmed:22950410 | path(MESH:Anxiety) association p(HGNC:CRHR1) |
| pubmed:17009926 | path(MESH:Anxiety) association p(FPLX:CHRN) |
| pubmed:11230871 | path(MESH:Anxiety) association p(FPLX:CHRN) |
| pubmed:21482353 | path(MESH:Anxiety) association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:28901280 | path(MESH:Anxiety) association p(MESH:"Receptors, Nicotinic") |
| pubmed:28775333 | path(MESH:Anxiety) positiveCorrelation p(MGI:Dyrk1a) |
| pubmed:28745240 | act(p(HGNC:PRKACA)) increases act(p(HGNC:CREB1)) |
| pubmed:21214928 | p(HGNC:PRKACA) decreases a(CHEBI:amyloid-beta) |
| pubmed:26979166 | act(p(HGNC:PRKACA)) directlyIncreases bp(GO:"protein kinase A signaling") |
| pubmed:26979166 | act(p(HGNC:PRKACA)) increases p(HGNC:CHRNA7, pmod(go:0006468 ! "protein phosphorylation", Ser, 365)) |
| pubmed:26979166 | p(HGNC:PRKACA) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:26979166 | p(HGNC:PRKACA) increases p(HGNC:CREB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 133)) |
| pubmed:8282104 | p(HGNC:PRKACA) association a(GO:microtubule) |
| pubmed:8282104 | p(HGNC:PRKACA) association a(CONSO:CONSO00006) |
| pubmed:17493042 | p(HGNC:PRKACA) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser)) |
| pubmed:28745240 | act(p(HGNC:CREB1)) increases bp(GO:"long-term memory") |
| pubmed:21677163 | bp(GO:"long-term memory") positiveCorrelation p(FPLX:CREB) |
| pubmed:28745240 | bp(GO:"calcium ion homeostasis") increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:21214928 | bp(GO:"calcium ion homeostasis") association p(HGNC:APP) |
| pubmed:19293145 | bp(GO:"calcium ion homeostasis") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:23516100 | bp(GO:"calcium ion homeostasis") negativeCorrelation path(DOID:"Alzheimer's disease") |
| pubmed:23516100 | bp(GO:"calcium ion homeostasis") negativeCorrelation path(DOID:"Parkinson's disease") |
| pubmed:23516100 | bp(GO:"calcium ion homeostasis") negativeCorrelation path(DOID:"Huntington's disease") |
| pubmed:23516100 | bp(GO:"calcium ion homeostasis") negativeCorrelation bp(CONSO:"Glutamate excitotoxicity") |
| pubmed:23516100 | bp(GO:"calcium ion homeostasis") negativeCorrelation path(DOID:"neurodegenerative disease") |
| pubmed:20556492 | bp(GO:"calcium ion homeostasis") association act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pubmed:21722302 | bp(GO:"calcium ion homeostasis") increases p(MESH:"Molecular Chaperones", loc(GO:"endoplasmic reticulum")) |
| pubmed:21722302 | bp(GO:"calcium ion homeostasis") increases act(p(MESH:"Molecular Chaperones", loc(GO:"endoplasmic reticulum"))) |
| pubmed:21722302 | bp(GO:"calcium ion homeostasis") increases bp(GO:"protein folding") |
| pubmed:21722302 | bp(GO:"calcium ion homeostasis") increases bp(MESH:"Unfolded Protein Response") |
| pubmed:29758300 | bp(GO:"calcium ion homeostasis") association p(HGNC:PSEN1) |
| pubmed:28745240 | bp(MESH:"Oxidative Stress") association a(CHEBI:amyloid-beta) |
| pubmed:28745240 | bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | bp(MESH:"Oxidative Stress") increases bp(GO:"apoptotic process") |
| pubmed:25652642 | bp(MESH:"Oxidative Stress") increases bp(GO:"apoptotic process") |
| pubmed:27623715 | bp(MESH:"Oxidative Stress") causesNoChange bp(GO:"apoptotic process") |
| pubmed:14970312 | bp(MESH:"Oxidative Stress") association path(MESH:"Alzheimer Disease") |
| pubmed:22020111 | bp(MESH:"Oxidative Stress") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26195256 | bp(MESH:"Oxidative Stress") increases path(MESH:"Alzheimer Disease") |
| pubmed:14970312 | bp(MESH:"Oxidative Stress") association bp(GO:"regulation of lipid metabolic process") |
| pubmed:14970312 | bp(MESH:"Oxidative Stress") increases a(CHEBI:ceramide) |
| pubmed:26979166 | bp(MESH:"Oxidative Stress") increases bp(MESH:Apoptosis) |
| pubmed:18986241 | bp(MESH:"Oxidative Stress") association act(p(HGNC:PLCG1)) |
| pubmed:18986241 | bp(MESH:"Oxidative Stress") association path(MESH:Aging) |
| pubmed:26195256 | bp(MESH:"Oxidative Stress") increases path(MESH:Aging) |
| pubmed:18986241 | bp(MESH:"Oxidative Stress") association path(MESH:"Nerve Degeneration") |
| pubmed:22020111 | bp(MESH:"Oxidative Stress") positiveCorrelation path(MESH:"Colorectal Neoplasms") |
| pubmed:21722302 | bp(MESH:"Oxidative Stress") increases bp(GO:"motor neuron apoptotic process") |
| pubmed:26195256 | bp(MESH:"Oxidative Stress") decreases bp(GO:"establishment of blood-brain barrier") |
| pubmed:21131359 | bp(MESH:"Oxidative Stress") increases tloc(p(HGNC:MAPT), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:27623715 | bp(MESH:"Oxidative Stress") increases act(p(FPLX:JNK)) |
| pubmed:27623715 | bp(MESH:"Oxidative Stress") increases act(a(MESH:"Microtubule-Associated Proteins")) |
| pubmed:27623715 | bp(MESH:"Oxidative Stress") increases a(CHEBI:"calcium(2+)") |
| pubmed:27623715 | bp(MESH:"Oxidative Stress") decreases p(HGNC:S100B) |
| pubmed:27623715 | bp(MESH:"Oxidative Stress") causesNoChange path(MESH:"Acidosis, Lactic") |
| pubmed:27623715 | bp(MESH:"Oxidative Stress") causesNoChange bp(GO:"amyloid fibril formation") |
| pubmed:23722080 | bp(MESH:"Oxidative Stress") decreases a(GO:mitochondrion) |
| pubmed:24355211 | bp(MESH:"Oxidative Stress") positiveCorrelation p(HGNC:GSK3B) |
| pubmed:8226987 | bp(MESH:"Oxidative Stress") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:7667312 | bp(MESH:"Oxidative Stress") increases a(CONSO:"paired helical filaments") |
| pubmed:28745240 | bp(GO:"JNK cascade") increases bp(GO:"apoptotic process") |
| pubmed:28745240 | bp(GO:"JNK cascade") increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:21722302 | bp(GO:"JNK cascade") increases bp(GO:autophagy) |
| pubmed:21722302 | bp(GO:"JNK cascade") regulates bp(GO:autophagy) |
| pubmed:21722302 | bp(GO:"JNK cascade") increases p(HGNC:BCL2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21722302 | bp(GO:"JNK cascade") negativeCorrelation p(HGNC:PRKN) |
| pubmed:30740335 | bp(GO:"JNK cascade") increases p(HBP:"amyloid-beta aggregates") |
| pubmed:28745240 | bp(GO:"Fas signaling pathway") increases bp(GO:"apoptotic process") |
| pubmed:28745240 | bp(GO:"Fas signaling pathway") increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | p(HGNC:BCL2L1) increases tloc(a(PUBCHEM:16057918), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28745240 | p(HGNC:BCL2L1) decreases bp(GO:"apoptotic process") |
| pubmed:30444369 | p(HGNC:BCL2L1) decreases bp(GO:"apoptotic process") |
| pubmed:25652642 | act(p(HGNC:BCL2L1)) decreases act(a(CHEBI:amyloid-beta)) |
| pubmed:28745240 | p(HGNC:BCL2) decreases bp(GO:"apoptotic process") |
| pubmed:25652642 | p(HGNC:BCL2) decreases bp(GO:"apoptotic process") |
| pubmed:30444369 | p(HGNC:BCL2) decreases bp(GO:"apoptotic process") |
| pubmed:22530628 | act(p(HGNC:BCL2)) increases bp(MESH:"Cell Survival") |
| pubmed:30697142 | p(HGNC:BCL2) decreases bp(GO:"programmed cell death") |
| pubmed:21722302 | p(HGNC:BCL2) association bp(MESH:"Endoplasmic Reticulum Stress") |
| pubmed:21722302 | p(HGNC:BCL2) decreases bp(MESH:Apoptosis) |
| pubmed:21722302 | p(HGNC:BCL2) decreases bp(MESH:Apoptosis) |
| pubmed:21722302 | p(HGNC:BCL2) regulates bp(GO:"calcium ion homeostasis") |
| pubmed:30740335 | p(HGNC:BCL2) decreases path(MESH:Apoptosis) |
| pubmed:23528736 | p(HGNC:BCL2) decreases bp(GO:autophagy) |
| pubmed:28745240 | p(HGNC:BCL2A1) decreases bp(GO:"apoptotic process") |
| pubmed:28745240 | a(CHEBI:etoposide) increases bp(GO:"apoptotic process") |
| pubmed:29196815 | a(MESH:"Amyloid beta-Peptides") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22122372 | a(MESH:"Amyloid beta-Peptides") association path(MESH:"Alzheimer Disease") |
| pubmed:18650430 | a(MESH:"Amyloid beta-Peptides") increases bp(GO:"cell adhesion") |
| pubmed:22122372 | a(MESH:"Amyloid beta-Peptides") association a(CONSO:CONSO00018) |
| pubmed:31248781 | a(MESH:"Amyloid beta-Peptides") increases bp(MESH:Neuroprotection) |
| pubmed:11230871 | a(MESH:"Amyloid beta-Peptides") negativeCorrelation p(FPLX:CHRN) |
| pubmed:29758300 | a(MESH:"Amyloid beta-Peptides") association complex(GO:"gamma-secretase complex") |
| pubmed:14556719 | a(MESH:"Amyloid beta-Peptides") association path(MESH:"Plaque, Amyloid") |
| pubmed:28745240 | a(CHEBI:peroxynitrite) increases p(MESH:Proteins, pmod(CONSO:nitration)) |
| pubmed:16566606 | a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(CONSO:nitration)) |
| pubmed:21210655 | a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(CONSO:formylation, Lys)) |
| pubmed:21210655 | a(CHEBI:peroxynitrite) increases bp(GO:"response to nitrosative stress") |
| pubmed:16816118 | a(CHEBI:peroxynitrite) increases p(RGD:Mapt, pmod(CONSO:hyperphosphorylation)) |
| pubmed:16816118 | a(CHEBI:peroxynitrite) increases p(RGD:Mapt, pmod(CONSO:nitration)) |
| pubmed:16816118 | a(CHEBI:peroxynitrite) increases act(p(RGD:Gsk3b)) |
| pubmed:16816118 | a(CHEBI:peroxynitrite) increases act(p(RGD:Mapk14)) |
| pubmed:16816118 | a(CHEBI:peroxynitrite) increases act(p(RGD:Mapk11)) |
| pubmed:16816118 | a(CHEBI:peroxynitrite) increases act(p(RGD:Mapk13)) |
| pubmed:16816118 | a(CHEBI:peroxynitrite) causesNoChange act(p(RGD:Mapk12)) |
| pubmed:16816118 | a(CHEBI:peroxynitrite) causesNoChange act(p(FPLX:ERK)) |
| pubmed:16816118 | a(CHEBI:peroxynitrite) causesNoChange act(p(FPLX:JNK)) |
| pubmed:16816118 | a(CHEBI:peroxynitrite) increases a(CONSO:"Tau aggregates") |
| pubmed:16566606 | a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) |
| pubmed:16566606 | a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) |
| pubmed:16566606 | a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) |
| pubmed:16566606 | a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) |
| pubmed:16566606 | a(CHEBI:peroxynitrite) increases a(CONSO:"3-3 dityrosine cross-linking") |
| pubmed:27314526 | a(CHEBI:peroxynitrite) increases bp(GO:"DNA conformation change") |
| pubmed:27314526 | a(CHEBI:peroxynitrite) decreases bp(GO:"energy reserve metabolic process") |
| pubmed:28745240 | composite(a(CHEBI:"kainic acid"), complex(GO:"NF-kappaB complex")) regulates bp(MESH:Neuroprotection) |
| pubmed:28745240 | composite(a(CHEBI:"kainic acid"), complex(GO:"NF-kappaB complex")) decreases path(MESH:Ischemia) |
| pubmed:30935091 | a(CHEBI:"kainic acid") increases path(DOID:"axonal neuropathy") |
| pubmed:19293145 | bp(MESH:Neuroprotection) association p(HGNC:FYN) |
| pubmed:19293145 | bp(MESH:Neuroprotection) association bp(GO:"calcium-mediated signaling") |
| pubmed:19293145 | bp(MESH:Neuroprotection) association a(MESH:Calcineurin) |
| pubmed:19293145 | bp(MESH:Neuroprotection) association p(HGNC:JAK2) |
| pubmed:27190210 | bp(MESH:Neuroprotection) association p(HGNC:CHRNA7) |
| pubmed:19721446 | bp(MESH:Neuroprotection) association p(HGNC:CHRNA7) |
| pubmed:27190210 | bp(MESH:Neuroprotection) association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:31248781 | bp(MESH:Neuroprotection) association complex(GO:"neurotransmitter receptor complex") |
| pubmed:31248781 | bp(MESH:Neuroprotection) negativeCorrelation bp(GO:"stress-activated protein kinase signaling cascade") |
| pubmed:31248781 | bp(MESH:Neuroprotection) negativeCorrelation act(p(MESH:Caspases)) |
| pubmed:31248781 | bp(MESH:Neuroprotection) positiveCorrelation bp(MESH:"Cell Survival") |
| pubmed:31248781 | bp(MESH:Neuroprotection) association bp(CONSO:"PI3K-Akt signaling pathway") |
| pubmed:31248781 | bp(MESH:Neuroprotection) association p(HGNC:CREBBP) |
| pubmed:19721446 | bp(MESH:Neuroprotection) association a(CHEBI:nicotine) |
| pubmed:21722302 | path(MESH:Ischemia) increases act(p(HGNC:PRKAA1)) |
| pubmed:28745240 | composite(a(CHEBI:"linolenic acid"), complex(GO:"NF-kappaB complex")) regulates bp(MESH:Neuroprotection) |
| pubmed:28745240 | composite(a(CHEBI:"linolenic acid"), complex(GO:"NF-kappaB complex")) decreases path(MESH:Ischemia) |
| pubmed:24653673 | bp(GO:neurogenesis) negativeCorrelation act(p(HGNC:GSK3B)) |
| pubmed:24653673 | bp(GO:neurogenesis) negativeCorrelation act(p(HGNC:CDK5)) |
| pubmed:24653673 | bp(GO:neurogenesis) negativeCorrelation act(p(FPLX:ERK)) |
| pubmed:26631930 | bp(GO:neurogenesis) association p(HGNC:MAPT) |
| pubmed:26631930 | bp(GO:neurogenesis) association p(HGNC:MAPT) |
| pubmed:28745240 | p(HGNC:FGF2) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | p(HGNC:EGF) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:30935091 | p(HGNC:EGF) increases p(HGNCGENEFAMILY:"Beta catenins", loc(GO:nucleus)) |
| pubmed:23393546 | p(HGNC:EGF) increases bp(GO:"MAPK cascade") |
| pubmed:28745240 | p(HGNC:VEGFA) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:21861815 | p(HGNC:VEGFA) increases bp(GO:"blood vessel development") |
| pubmed:21861815 | p(HGNC:VEGFA) increases bp(GO:"blood vessel development") |
| pubmed:21861815 | p(HGNC:VEGFA) negativeCorrelation path(EFO:hypoxemia) |
| pubmed:21861815 | act(p(HGNC:VEGFA)) negativeCorrelation path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:21861815 | p(HGNC:VEGFA) decreases path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:21861815 | p(HGNC:VEGFA) increases a(MESH:"Dopaminergic Neurons") |
| pubmed:21861815 | p(HGNC:VEGFA) decreases bp(GO:"cell death") |
| pubmed:26304819 | p(HGNC:VEGFA) biomarkerFor path(MESH:"Alzheimer Disease") |
| pubmed:28745240 | p(HGNC:EPO) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:21861815 | p(HGNC:EPO) decreases bp(GO:"neuron death") |
| pubmed:21861815 | p(HGNC:EPO) decreases act(a(CONSO:"amyloid-beta aggregates")) |
| pubmed:21861815 | p(HGNC:EPO) decreases a(CHEBI:oxidopamine) |
| pubmed:28745240 | path(MESH:"Cerebral Infarction") increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | path(MESH:"Cerebral Infarction") increases bp(GO:neurogenesis) |
| pubmed:28745240 | path(MESH:"Brain Injuries, Traumatic") increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | path(MESH:"Brain Injuries, Traumatic") increases bp(GO:neurogenesis) |
| pubmed:21722302 | path(MESH:"Brain Injuries, Traumatic") association bp(CONSO:"protein aggregation") |
| pubmed:30126037 | path(MESH:"Brain Injuries, Traumatic") association p(HGNC:MAPT) |
| pubmed:29626319 | path(MESH:"Brain Injuries, Traumatic") increases p(HGNC:MAPT) |
| pubmed:26195256 | path(MESH:"Brain Injuries, Traumatic") association p(CONSO:"Tau aggregates") |
| pubmed:29626319 | path(MESH:"Brain Injuries, Traumatic") decreases p(HGNC:AQP4) |
| pubmed:29626319 | path(MESH:"Brain Injuries, Traumatic") decreases act(p(HGNC:AQP4)) |
| pubmed:29626319 | path(MESH:"Brain Injuries, Traumatic") decreases p(HGNC:AQP4) |
| pubmed:29626319 | path(MESH:"Brain Injuries, Traumatic") decreases a(HP:"glymphatic system") |
| pubmed:29626319 | path(MESH:"Brain Injuries, Traumatic") decreases a(HP:"glymphatic system") |
| pubmed:24561250 | path(MESH:"Brain Injuries, Traumatic") increases bp(GO:"cell death") |
| pubmed:28745240 | path(MESH:Hypoxia) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | path(MESH:Hypoxia) increases bp(GO:neurogenesis) |
| pubmed:21722302 | path(MESH:Hypoxia) increases act(p(HGNC:PRKAA1)) |
| pubmed:28745240 | p(CONSO:sAPP-alpha) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | p(CONSO:sAPP-alpha) increases bp(GO:neurogenesis) |
| pubmed:24590577 | p(CONSO:sAPP-alpha) increases bp(MESH:Neuroprotection) |
| pubmed:28745240 | a(CHEBI:"sphingosine 1-phosphate") increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | a(CHEBI:"sphingosine 1-phosphate") increases bp(GO:neurogenesis) |
| pubmed:28745240 | a(CHEBI:"nitric oxide") decreases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | a(CHEBI:"nitric oxide") decreases bp(GO:neurogenesis) |
| pubmed:27794524 | a(CHEBI:"nitric oxide") isA a(MESH:Neurotoxins) |
| pubmed:27794524 | a(CHEBI:"nitric oxide") decreases path(MESH:"Neural Conduction") |
| pubmed:27794524 | a(CHEBI:"nitric oxide") decreases bp(GO:"spinal cord development") |
| pubmed:26445701 | a(CHEBI:"nitric oxide") increases path(HP:"CNS demyelination") |
| pubmed:26445701 | a(CHEBI:"nitric oxide") increases path(MESH:"Diffuse Axonal Injury") |
| pubmed:26445701 | a(CHEBI:"nitric oxide") increases bp(GO:"positive regulation of oligodendrocyte apoptotic process") |
| pubmed:30515821 | a(CHEBI:"nitric oxide") increases p(NCBIGENE:74006, pmod(go:0017014 ! "protein nitrosylation", Cys, 644)) |
| pubmed:30515821 | a(CHEBI:"nitric oxide") increases p(HGNC:DNM1, pmod(go:0017014 ! "protein nitrosylation", Cys, 644)) |
| pubmed:30515821 | a(CHEBI:"nitric oxide") increases p(NCBIGENE:74006, pmod(go:0017014 ! "protein nitrosylation")) |
| pubmed:30515821 | a(CHEBI:"nitric oxide") increases p(HGNC:DNM1L, pmod(go:0017014 ! "protein nitrosylation")) |
| pubmed:30688256 | a(CHEBI:"nitric oxide") increases bp(GO:"mitochondrial fission") |
| pubmed:29559585 | a(CHEBI:"nitric oxide") increases p(MGI:Gapdh, pmod(go:0017014 ! "protein nitrosylation")) |
| pubmed:27601475 | a(CHEBI:"nitric oxide") positiveCorrelation a(CONSO:8-nitro-cGMP) |
| pubmed:23702978 | a(CHEBI:"nitric oxide") increases p(HGNC:NLRP3, pmod(go:0017014 ! "protein nitrosylation")) |
| pubmed:27314526 | a(CHEBI:"nitric oxide") increases a(CHEBI:peroxynitrite) |
| pubmed:27314526 | a(CHEBI:"nitric oxide") increases act(p(HGNC:CASP3)) |
| pubmed:27314526 | a(CHEBI:"nitric oxide") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27314526 | a(CHEBI:"nitric oxide") increases bp(GO:"p38MAPK cascade") |
| pubmed:28745240 | path(HP:"Ischemic stroke") increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | path(HP:Seizures) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | a(MESH:"Cerebral Cortex") negativeCorrelation act(complex(GO:"NF-kappaB complex")) |
| pubmed:24511233 | a(MESH:"Cerebral Cortex") association bp(GO:cognition) |
| pubmed:24511233 | a(MESH:"Cerebral Cortex") association bp(GO:learning) |
| pubmed:24511233 | a(MESH:"Cerebral Cortex") association bp(GO:learning) |
| pubmed:24511233 | a(MESH:"Cerebral Cortex") association bp(GO:memory) |
| pubmed:24511233 | a(MESH:"Cerebral Cortex") association bp(GO:memory) |
| pubmed:24590577 | a(MESH:"Cerebral Cortex") association p(HGNC:CHRM1) |
| pubmed:26195256 | a(MESH:"Cerebral Cortex") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:28745240 | p(HGNC:IL6) increases bp(GO:"astrocyte development") |
| pubmed:28745240 | p(HGNC:IL6) increases p(HGNC:STAT3) |
| pubmed:28745240 | p(HGNC:IL6) increases a(MESH:"Transcription Factor AP-1") |
| pubmed:28745240 | p(HGNC:IL6) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | p(HGNC:IL6) association path(MESH:"Alzheimer Disease") |
| pubmed:25652642 | p(HGNC:IL6) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:28745240 | p(HGNC:IL6) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:28745240 | p(HGNC:IL6) increases bp(GO:"neuron death") |
| pubmed:27794524 | p(HGNC:IL6) isA a(MESH:Cytokines) |
| pubmed:27794524 | p(HGNC:IL6) positiveCorrelation path(MESH:"Complement Activation") |
| pubmed:27794524 | p(HGNC:IL6) positiveCorrelation act(p(MESH:T-Lymphocytes)) |
| pubmed:27794524 | p(HGNC:IL6) directlyDecreases a(MESH:Oligodendroglia) |
| pubmed:30967783 | p(HGNC:IL6) increases bp(GO:"inflammatory response") |
| pubmed:30967783 | p(HGNC:IL6) increases path(EFO:"experimental autoimmune encephalomyelitis") |
| pubmed:30967783 | p(HGNC:IL6) decreases path(EFO:"experimental autoimmune encephalomyelitis") |
| pubmed:30967783 | p(HGNC:IL6) increases path(DOID:"multiple sclerosis") |
| pubmed:30967783 | p(HGNC:IL6) increases path(MESH:Inflammation) |
| pubmed:26979166 | p(HGNC:IL6) increases path(MESH:Inflammation) |
| pubmed:30988501 | p(HGNC:IL6) regulates path(MESH:Inflammation) |
| pubmed:30967783 | p(HGNC:IL6) positiveCorrelation path(HP:Autoimmunity) |
| pubmed:30988501 | p(HGNC:IL6) increases a(MESH:"Neural Pathways") |
| pubmed:30988501 | p(HGNC:IL6) increases act(a(MESH:Microglia)) |
| pubmed:30988501 | p(HGNC:IL6) negativeCorrelation path(DOID:schizophrenia) |
| pubmed:30988501 | p(HGNC:IL6) negativeCorrelation path(DOID:"mental depression") |
| pubmed:30988501 | p(HGNC:IL6) negativeCorrelation path(DOID:"post-traumatic stress disorder") |
| pubmed:30988501 | p(HGNC:IL6) increases p(HGNC:IL17A) |
| pubmed:28745240 | a(MESH:"Transcription Factor AP-1") increases bp(GO:"astrocyte development") |
| pubmed:28745240 | p(HGNC:LIF) increases bp(GO:"astrocyte development") |
| pubmed:28745240 | p(HGNC:LIF) increases p(HGNC:STAT3) |
| pubmed:28745240 | p(HGNC:LIF) increases a(MESH:"Transcription Factor AP-1") |
| pubmed:28745240 | p(HGNC:LIF) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | p(HGNC:CNTF) increases bp(GO:"astrocyte development") |
| pubmed:28745240 | p(HGNC:CNTF) increases p(HGNC:STAT3) |
| pubmed:28745240 | p(HGNC:CNTF) increases a(MESH:"Transcription Factor AP-1") |
| pubmed:28745240 | p(HGNC:CNTF) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | p(HGNC:CNTF) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | p(HGNC:CNTF) increases bp(MESH:"Neuronal Outgrowth") |
| pubmed:28745240 | p(HGNC:CNTF) increases act(p(HGNC:LCK)) |
| pubmed:28745240 | bp(MESH:"Neuronal Outgrowth") negativeCorrelation p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation", Ser, 536)) |
| pubmed:27288790 | bp(MESH:"Neuronal Outgrowth") association p(FPLX:NFkappaB) |
| pubmed:21214928 | bp(MESH:"Neuronal Outgrowth") association p(HGNC:APP) |
| pubmed:23383175 | act(a(GO:axon)) decreases path(MESH:Paralysis) |
| pubmed:23383175 | act(a(GO:axon)) decreases path(HP:"Limb muscle weakness") |
| pubmed:27807169 | a(GO:axon) positiveCorrelation p(RGD:Cdk5r2) |
| pubmed:28745240 | act(p(HGNC:SRC)) increases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 42)) |
| pubmed:29661268 | act(p(HGNC:SRC), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19293145 | p(HGNC:SRC) increases bp(MESH:Neuroprotection) |
| pubmed:24653673 | p(HGNC:SRC) increases p(HGNC:PPP2CA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) |
| pubmed:24653673 | p(HGNC:SRC) increases p(HGNC:PPP2CA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) |
| pubmed:24653673 | p(HGNC:SRC) increases p(HGNC:PPP2CB, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) |
| pubmed:24653673 | p(HGNC:SRC) increases p(HGNC:PPP2CB, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) |
| pubmed:29191965 | p(HGNC:SRC) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr)) |
| pubmed:26751493 | p(HGNC:SRC) association p(CONSO:"projection domain") |
| pubmed:18467332 | p(HGNC:SRC) isA complex(p(HGNC:MAPT), p(HGNC:SRC)) |
| pubmed:28745240 | p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 42)) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:27288790 | p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 42)) increases act(p(FPLX:NFkappaB)) |
| pubmed:29179999 | p(HGNC:NFKBIA) decreases act(p(FPLX:NFkappaB, loc(MESH:Cytosol))) |
| pubmed:27288790 | p(HGNC:NFKBIA) decreases act(p(FPLX:NFkappaB, loc(MESH:Cytosol))) |
| pubmed:26551702 | p(HGNC:NFKBIA) decreases act(p(FPLX:NFkappaB)) |
| pubmed:26551702 | deg(p(HGNC:NFKBIA)) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pubmed:28745240 | act(p(HGNC:LCK)) increases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 42)) |
| pubmed:30640040 | p(HGNC:LCK) association a(PUBCHEM:4878) |
| pubmed:29191965 | p(HGNC:LCK) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr)) |
| pubmed:26751493 | p(HGNC:LCK) association p(CONSO:"projection domain") |
| pubmed:26631930 | p(HGNC:LCK) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) |
| pubmed:10887109 | act(p(HGNC:LCK), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:10887109 | act(p(HGNC:LCK), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr)) |
| pubmed:10887109 | act(p(HGNC:LCK), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr), var("p.Tyr358Phe")) |
| pubmed:10887109 | act(p(HGNC:LCK), ma(go:0016301 ! "kinase activity")) causesNoChange p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr), var("p.Tyr340Phe")) |
| pubmed:10887109 | act(p(HGNC:LCK), ma(go:0016301 ! "kinase activity")) causesNoChange p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr), var("p.Tyr340Phe"), var("p.Tyr358Phe")) |
| pubmed:10887109 | act(p(HGNC:LCK), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)) |
| pubmed:10887109 | act(p(HGNC:LCK), ma(go:0016301 ! "kinase activity")) increases p(HGNC:PECAM1, pmod(go:0006468 ! "protein phosphorylation", Tyr, 686)) |
| pubmed:28745240 | p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation", Ser, 536)) negativeCorrelation bp(MESH:"Neuronal Outgrowth") |
| pubmed:28745240 | bp(GO:"axon guidance") increases bp(GO:neurogenesis) |
| pubmed:28745240 | bp(GO:"axon guidance") increases a(GO:axon) |
| pubmed:21861815 | bp(GO:"axon guidance") association p(HGNC:NRP1) |
| pubmed:28745240 | p(HGNC:ITGB1) increases bp(GO:"axon guidance") |
| pubmed:28745240 | p(HGNC:ITGB1) increases a(GO:axon) |
| pubmed:21214928 | p(HGNC:ITGB1) association p(HGNC:APP) |
| pubmed:28745240 | p(HGNC:NCAM1) increases a(GO:axon) |
| pubmed:28745240 | p(HGNC:SLITRK1) increases a(GO:axon) |
| pubmed:28745240 | p(HGNC:GFRA1) increases a(GO:axon) |
| pubmed:28745240 | p(HGNC:TIAM1) increases a(GO:axon) |
| pubmed:22020111 | act(a(MESH:"Dendritic Cells")) increases bp(GO:"T cell activation") |
| pubmed:28745240 | p(HGNC:HES1) regulates a(GO:"dendritic branch") |
| pubmed:28745240 | p(HGNC:HES1) regulates a(MESH:"Dendritic Cells") |
| pubmed:28745240 | p(HGNC:HES5) regulates a(GO:"dendritic branch") |
| pubmed:28745240 | p(HGNC:HES5) regulates a(MESH:"Dendritic Cells") |
| pubmed:28745240 | p(HGNC:MAP1B) increases a(MESH:"Dendritic Cells") |
| pubmed:28745240 | p(HGNC:MAP2) increases a(MESH:"Dendritic Cells") |
| pubmed:30061532 | p(HGNC:MAP2) increases a(GO:microtubule) |
| pubmed:30061532 | p(HGNC:MAP2) increases bp(GO:"dendritic spine organization") |
| pubmed:30061532 | p(HGNC:MAP2) increases bp(GO:"cytoskeleton organization") |
| pubmed:28669544 | p(HGNC:MAP2) causesNoChange p(HGNC:DLG4) |
| pubmed:30988501 | p(HGNC:C3) increases bp(GO:"complement-mediated synapse pruning") |
| pubmed:30988501 | p(HGNC:C4A) positiveCorrelation path(DOID:schizophrenia) |
| pubmed:28745240 | complex(a(GO:"membrane attack complex"), p(HGNC:C5)) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:28745240 | p(HGNC:IL1B) increases bp(GO:"neuron death") |
| pubmed:27288790 | p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25652642 | p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24561250 | p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27314526 | p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27288790 | p(HGNC:IL1B) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pubmed:26551702 | p(HGNC:IL1B) increases act(p(FPLX:NFkappaB)) |
| pubmed:27288790 | p(HGNC:IL1B) increases p(FPLX:"IKK_complex", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27288790 | p(HGNC:IL1B) increases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27288790 | p(HGNC:IL1B) decreases p(FPLX:IKB) |
| pubmed:27288790 | p(HGNC:IL1B) increases a(MESH:Cytokines) |
| pubmed:27288790 | p(HGNC:IL1B) increases a(MESH:Chemokines) |
| pubmed:30962309 | p(HGNC:IL1B) association path(DOID:cancer) |
| pubmed:30962309 | p(HGNC:IL1B) association path(DOID:"multiple sclerosis") |
| pubmed:30967783 | p(HGNC:IL1B) increases path(DOID:"multiple sclerosis") |
| pubmed:30962309 | p(HGNC:IL1B) association path(DOID:"rheumatic disease") |
| pubmed:30962309 | act(p(HGNC:IL1B)) increases path(DOID:"neurodegenerative disease") |
| pubmed:26445701 | p(HGNC:IL1B) increases path(HP:"CNS demyelination") |
| pubmed:26445701 | p(HGNC:IL1B) increases path(MESH:"Diffuse Axonal Injury") |
| pubmed:26445701 | p(HGNC:IL1B) increases bp(GO:"positive regulation of oligodendrocyte apoptotic process") |
| pubmed:30967783 | p(HGNC:IL1B) increases bp(GO:"inflammatory response") |
| pubmed:24561250 | p(HGNC:IL1B) increases bp(GO:"inflammatory response") |
| pubmed:30967783 | p(HGNC:IL1B) increases path(EFO:"experimental autoimmune encephalomyelitis") |
| pubmed:30967783 | p(HGNC:IL1B) increases path(EFO:"experimental autoimmune encephalomyelitis") |
| pubmed:30967783 | p(HGNC:IL1B) positiveCorrelation bp(GO:"T-helper 17 cell chemotaxis") |
| pubmed:23092889 | p(HGNC:IL1B) increases bp(GO:pyroptosis) |
| pubmed:23702978 | act(p(HGNC:IL1B)) increases bp(GO:"neutrophil activation") |
| pubmed:24561250 | p(HGNC:IL1B) positiveCorrelation complex(GO:"inflammasome complex") |
| pubmed:27314526 | p(HGNC:IL1B) positiveCorrelation path(MESH:Dementia) |
| pubmed:27314526 | p(HGNC:IL1B) increases bp(GO:"microglial cell activation") |
| pubmed:27314526 | p(HGNC:IL1B) increases bp(GO:"astrocyte activation") |
| pubmed:27314526 | tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases p(HGNC:APP) |
| pubmed:27314526 | tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases a(CHEBI:amyloid-beta) |
| pubmed:30988501 | p(HGNC:IL1B) increases a(MESH:"Neural Pathways") |
| pubmed:30988501 | p(HGNC:IL1B) increases act(a(MESH:Microglia)) |
| pubmed:30988501 | p(HGNC:IL1B) negativeCorrelation path(DOID:schizophrenia) |
| pubmed:30988501 | p(HGNC:IL1B) negativeCorrelation path(DOID:"mental depression") |
| pubmed:30988501 | p(HGNC:IL1B) negativeCorrelation path(DOID:"post-traumatic stress disorder") |
| pubmed:28745240 | bp(GO:"p38MAPK cascade") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:25514383 | bp(GO:"p38MAPK cascade") increases a(CONSO:"Tau aggregates") |
| pubmed:27314526 | bp(GO:"p38MAPK cascade") increases complex(GO:"neurofibrillary tangle") |
| pubmed:30145931 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) positiveCorrelation a(CONSO:"amyloid-beta oligomers") |
| pubmed:28784767 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) increases a(CONSO:"Tau Protein Secondary Structure, Turn") |
| pubmed:21882945 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:28745240 | act(complex(p(HGNC:CDK5), p(HGNC:CDK5R1))) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:26118667 | complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) increases act(p(HGNC:CDK5)) |
| pubmed:26118667 | p(HGNC:CDK5) increases complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) |
| pubmed:29661268 | act(p(HGNC:CDK5), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19419557 | act(p(HGNC:CDK5), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:12428809 | p(HGNC:CDK5) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29758300 | p(HGNC:CDK5) regulates p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:8282104 | p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21882945 | act(p(HGNC:CDK5)) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29191965 | p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27314526 | p(HGNC:CDK5) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30444369 | p(HGNC:CDK5) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | p(HGNC:CDK5) association path(MESH:"Alzheimer Disease") |
| pubmed:8282104 | p(HGNC:CDK5) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:30444369 | p(HGNC:CDK5) increases p(HGNC:PRDX2, pmod(go:0006468 ! "protein phosphorylation", Thr, 89)) |
| pubmed:22122372 | p(HGNC:CDK5) increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 654)) |
| pubmed:22122372 | p(HGNC:CDK5) increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) |
| pubmed:22122372 | p(HGNC:CDK5) increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Ser, 665)) |
| pubmed:30061532 | p(HGNC:CDK5) regulates p(HGNC:DPYSL2) |
| pubmed:30061532 | p(HGNC:CDK5) positiveCorrelation a(GO:"dendritic spine") |
| pubmed:30061532 | p(HGNC:CDK5) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:25001178 | act(p(HGNC:CDK5), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:30061532 | act(p(HGNC:CDK5)) positiveCorrelation path(MESH:Schizophrenia) |
| pubmed:30061532 | act(p(HGNC:CDK5)) negativeCorrelation p(HGNC:CDK5R1) |
| pubmed:30515821 | act(p(HGNC:CDK5)) increases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 579)) |
| pubmed:30515821 | p(HGNC:CDK5) increases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 585)) |
| pubmed:30515821 | p(HGNC:CDK5) increases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) |
| pubmed:30515821 | act(p(HGNC:CDK5)) association path(MESH:"Wounds and Injuries") |
| pubmed:30515821 | act(p(HGNC:CDK5)) increases bp(GO:"programmed cell death") |
| pubmed:24653673 | act(p(HGNC:CDK5)) negativeCorrelation a(GO:"microtubule cytoskeleton") |
| pubmed:24653673 | act(p(HGNC:CDK5)) negativeCorrelation a(GO:"neurofilament cytoskeleton") |
| pubmed:24653673 | act(p(HGNC:CDK5)) negativeCorrelation p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | act(p(HGNC:CDK5)) negativeCorrelation bp(CONSO:"APP processing") |
| pubmed:24653673 | act(p(HGNC:CDK5)) negativeCorrelation bp(GO:neurogenesis) |
| pubmed:24653673 | act(p(HGNC:CDK5)) positiveCorrelation bp(GO:"negative regulation of synaptic plasticity") |
| pubmed:24653673 | act(p(HGNC:CDK5)) positiveCorrelation bp(GO:"apoptotic process") |
| pubmed:8282104 | p(HGNC:CDK5) directlyIncreases p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:8282104 | p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:17078951 | act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:8282104 | p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:8282104 | p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 235)) |
| pubmed:8282104 | p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:8282104 | p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:8282104 | p(HGNC:CDK5) association a(GO:microtubule) |
| pubmed:8282104 | p(HGNC:CDK5) association a(CONSO:CONSO00006) |
| pubmed:8282104 | p(HGNC:CDK5) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")))) |
| pubmed:21882945 | p(HGNC:CDK5) increases act(p(HGNC:MARK2)) |
| pubmed:21367866 | act(p(HGNC:CDK5), ma(go:0016301 ! "kinase activity")) negativeCorrelation p(HGNC:CDC37) |
| pubmed:27796283 | p(HGNC:CDK5) increases p(HGNC:CAMKV, pmod(go:0006468 ! "protein phosphorylation", Thr, 345)) |
| pubmed:17078951 | act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) |
| pubmed:17078951 | act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:17078951 | act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:17078951 | act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:8702879 | act(p(HGNC:CDK5)) increases p(HGNC:SYN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 551)) |
| pubmed:8702879 | act(p(HGNC:CDK5)) increases p(HGNC:SYN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 553)) |
| pubmed:26118667 | p(HGNC:CDK5R1) partOf complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) |
| pubmed:30061532 | p(HGNC:CDK5R1) negativeCorrelation path(MESH:Schizophrenia) |
| pubmed:30061532 | p(HGNC:CDK5R1) negativeCorrelation act(p(HGNC:CDK5)) |
| pubmed:26118667 | p(HGNC:CDK5R1) increases bp(GO:"neuron maturation") |
| pubmed:26118667 | p(HGNC:CDK5R1) negativeCorrelation p(CONSO:"CDK5R1 p25") |
| pubmed:19126755 | path(CONSO:neurotoxicity) association a(CHEBI:nicotine) |
| pubmed:19293145 | path(CONSO:neurotoxicity) association a(CONSO:"amyloid-beta oligomers") |
| pubmed:19293145 | path(CONSO:neurotoxicity) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:22908190 | path(CONSO:neurotoxicity) positiveCorrelation a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:24027553 | path(CONSO:neurotoxicity) positiveCorrelation a(CONSO:"Tau aggregates") |
| pubmed:29686391 | path(CONSO:neurotoxicity) positiveCorrelation a(CONSO:"Tau oligomers") |
| pubmed:26671985 | path(CONSO:neurotoxicity) positiveCorrelation a(CONSO:"Tau oligomers") |
| pubmed:26671985 | path(CONSO:neurotoxicity) negativeCorrelation act(complex(GO:axon)) |
| pubmed:26671985 | path(CONSO:neurotoxicity) association p(HGNC:MAPT, var("p.Asp421*")) |
| pubmed:25652642 | bp(CONSO:"APP processing") positiveCorrelation act(complex(GO:"NF-kappaB complex")) |
| pubmed:25652642 | bp(CONSO:"APP processing") increases a(CHEBI:amyloid-beta) |
| pubmed:27094130 | bp(CONSO:"APP processing") increases a(CHEBI:amyloid-beta) |
| pubmed:24653673 | bp(CONSO:"APP processing") negativeCorrelation act(p(HGNC:GSK3B)) |
| pubmed:24653673 | bp(CONSO:"APP processing") negativeCorrelation act(p(HGNC:CDK5)) |
| pubmed:24653673 | bp(CONSO:"APP processing") negativeCorrelation act(p(FPLX:ERK)) |
| pubmed:30116051 | bp(CONSO:"APP processing") association p(HGNC:LRRK2, var("?")) |
| pubmed:24027553 | bp(CONSO:"APP processing") association p(HGNC:HTRA1) |
| pubmed:24027553 | bp(CONSO:"APP processing") association path(MESH:"Alzheimer Disease") |
| pubmed:27094130 | bp(CONSO:"APP processing") association p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) |
| pubmed:28745240 | complex(p(HGNC:BACE1), p(HGNC:NFKB1), p(HGNC:RELA)) increases p(HGNC:BACE1) |
| pubmed:28745240 | complex(p(HGNC:NFKB2), p(HGNC:RELA)) increases complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA)) |
| pubmed:28745240 | complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA)) increases p(HGNC:BACE1) |
| pubmed:28745240 | complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA)) decreases p(HGNC:BACE1) |
| pubmed:28745240 | complex(p(HGNC:NFKB2), p(HGNC:REL)) increases complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:REL)) |
| pubmed:28745240 | p(HGNC:SOD2) decreases bp(MESH:"Oxidative Stress") |
| pubmed:28745240 | p(HGNC:SOD2) decreases bp(GO:"apoptotic process") |
| pubmed:25652642 | act(p(HGNC:SOD2)) decreases act(a(CHEBI:amyloid-beta)) |
| pubmed:30962309 | p(HGNC:SOD2) decreases a(CHEBI:"reactive oxygen species") |
| pubmed:24563850 | p(HGNC:SOD2) increases rxn(reactants(a(CHEBI:superoxide)), products(a(CHEBI:"hydrogen peroxide"), a(CHEBI:dioxygen))) |
| pubmed:28745240 | act(complex(GO:"calcium- and calmodulin-dependent protein kinase complex")) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:30515821 | complex(GO:"calcium- and calmodulin-dependent protein kinase complex") increases bp(GO:"mitochondrial fission") |
| pubmed:28745240 | a(MESH:Calcineurin) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:19293145 | a(MESH:Calcineurin) association act(a(CHEBI:nicotine)) |
| pubmed:19293145 | a(MESH:Calcineurin) association bp(MESH:Neuroprotection) |
| pubmed:28745240 | p(HGNC:CXCL8) increases bp(GO:"neuron death") |
| pubmed:29179999 | act(p(FPLX:ERK)) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pubmed:27288790 | p(FPLX:ERK) increases act(p(FPLX:NFkappaB)) |
| pubmed:19293145 | p(FPLX:ERK) association a(CHEBI:nicotine) |
| pubmed:24653673 | act(p(FPLX:ERK)) negativeCorrelation a(GO:"microtubule cytoskeleton") |
| pubmed:24653673 | act(p(FPLX:ERK)) negativeCorrelation a(GO:"neurofilament cytoskeleton") |
| pubmed:24653673 | act(p(FPLX:ERK)) negativeCorrelation p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | act(p(FPLX:ERK)) negativeCorrelation bp(CONSO:"APP processing") |
| pubmed:24653673 | act(p(FPLX:ERK)) negativeCorrelation bp(GO:neurogenesis) |
| pubmed:24653673 | act(p(FPLX:ERK)) positiveCorrelation bp(GO:"negative regulation of synaptic plasticity") |
| pubmed:24653673 | act(p(FPLX:ERK)) positiveCorrelation bp(GO:"apoptotic process") |
| pubmed:12428809 | p(FPLX:ERK) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:8282104 | p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:8282104 | p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:8282104 | p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:8282104 | p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 235)) |
| pubmed:8282104 | p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:8282104 | p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:8282104 | p(FPLX:ERK) association a(GO:microtubule) |
| pubmed:8282104 | p(FPLX:ERK) association a(CONSO:CONSO00006) |
| pubmed:8282104 | p(FPLX:ERK) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")))) |
| pubmed:8282104 | p(FPLX:ERK) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27594586 | p(FPLX:ERK) regulates p(HGNC:MMP9) |
| pubmed:24686445 | act(p(FPLX:ERK)) increases act(p(HGNC:KAT2B)) |
| pubmed:25001178 | p(FPLX:ERK) increases act(p(HGNC:CDK5), ma(go:0016301 ! "kinase activity")) |
| pubmed:26551702 | p(FPLX:"NADPH_oxidase") increases a(CHEBI:radical) |
| pubmed:24563850 | act(p(FPLX:"NADPH_oxidase")) increases a(CHEBI:radical) |
| pubmed:24563850 | act(p(FPLX:"NADPH_oxidase")) increases a(CHEBI:"reactive oxygen species") |
| pubmed:27288790 | p(HGNC:PTGS2) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27288790 | p(HGNC:PTGS2) association a(CONSO:"amyloid-beta aggregates") |
| pubmed:19126755 | act(p(HGNC:PTGS2)) increases a(CHEBI:"prostaglandin H2") |
| pubmed:19126755 | p(HGNC:PTGS2, loc(MESH:Neurons)) regulates path(MESH:"Neuronal Plasticity") |
| pubmed:19126755 | p(HGNC:PTGS2, loc(MESH:Neurons)) regulates bp(GO:"cell death") |
| pubmed:19126755 | p(HGNC:PTGS2) association p(HGNC:CHRNA4) |
| pubmed:27314526 | tloc(a(MESH:Interleukins), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association path(MESH:Dementia) |
| pubmed:27314526 | tloc(a(MESH:Interleukins), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association path(CONSO:neuroinflammation) |
| pubmed:29179999 | r(HGNC:NLRP3) association act(p(FPLX:NFkappaB)) |
| pubmed:30962309 | r(HGNC:NLRP3) negativeCorrelation m(MIRBASE:hsa-mir-223) |
| pubmed:30962309 | r(HGNC:NLRP3) association m(MIRBASE:hsa-mir-133b) |
| pubmed:30962309 | r(HGNC:NLRP3) negativeCorrelation path(MESH:Neuralgia) |
| pubmed:23702978 | act(p(HGNC:NOS2)) increases a(CHEBI:"nitric oxide") |
| pubmed:27314526 | act(p(HGNC:NOS2)) increases a(CHEBI:"nitric oxide") |
| pubmed:26445701 | p(HGNC:IL2) regulates path(MESH:Inflammation) |
| pubmed:30988501 | p(HGNC:IL2) negativeCorrelation path(DOID:schizophrenia) |
| pubmed:30988501 | p(HGNC:IL2) negativeCorrelation path(DOID:"mental depression") |
| pubmed:30988501 | p(HGNC:IL2) negativeCorrelation path(DOID:"post-traumatic stress disorder") |
| pubmed:30967783 | p(HGNC:IL12B) increases path(MESH:Inflammation) |
| pubmed:27288790 | p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pubmed:26551702 | p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) increases complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFKBIA), p(HGNC:SKP1)) |
| pubmed:26551702 | p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) increases deg(p(HGNC:NFKBIA)) |
| pubmed:29179999 | a(CHEBI:resveratrol) decreases p(HGNC:TNF) |
| pubmed:29179999 | a(CHEBI:resveratrol) decreases p(HGNC:PTGS2) |
| pubmed:29179999 | a(CHEBI:resveratrol) decreases p(HGNC:PTGS2) |
| pubmed:29179999 | a(CHEBI:resveratrol) decreases a(MESH:Interleukins) |
| pubmed:29179999 | a(CHEBI:resveratrol) decreases p(FPLX:"IKK_complex", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29179999 | a(CHEBI:resveratrol) decreases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29179999 | a(CHEBI:resveratrol) decreases act(p(FPLX:NFkappaB)) |
| pubmed:29179999 | a(CHEBI:resveratrol) decreases p(HGNC:STAT1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29179999 | a(CHEBI:resveratrol) decreases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29179999 | a(CHEBI:resveratrol) decreases a(CHEBI:"nitric oxide") |
| pubmed:29179999 | a(CHEBI:resveratrol) decreases p(HGNC:NOS2) |
| pubmed:29179999 | a(CHEBI:resveratrol) decreases a(CHEBI:"prostaglandin E2") |
| pubmed:26551702 | a(CHEBI:resveratrol) decreases path(MESH:Inflammation) |
| pubmed:26551702 | a(CHEBI:resveratrol) increases act(p(HGNC:NFE2L2)) |
| pubmed:22020111 | a(CHEBI:resveratrol) decreases act(p(HGNC:NFE2L2)) |
| pubmed:26551702 | a(CHEBI:resveratrol) increases bp(GO:"response to oxidative stress") |
| pubmed:22020111 | a(CHEBI:resveratrol) increases act(p(HGNC:SIRT1)) |
| pubmed:27209302 | a(CHEBI:resveratrol) increases act(p(HGNC:SIRT1)) |
| pubmed:30116051 | a(CHEBI:resveratrol) increases act(p(HGNC:SIRT1)) |
| pubmed:30688256 | a(CHEBI:resveratrol) decreases act(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pubmed:30116051 | a(CHEBI:resveratrol) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:30688256 | a(CHEBI:resveratrol) decreases bp(GO:"apoptotic process") |
| pubmed:30688256 | a(CHEBI:resveratrol) increases bp(GO:mitophagy) |
| pubmed:27209302 | a(CHEBI:resveratrol) increases deg(p(CONSO:"amyloid-beta fibrils")) |
| pubmed:30116051 | a(CHEBI:resveratrol) increases act(p(HGNC:CAMKK2)) |
| pubmed:30116051 | a(CHEBI:resveratrol) decreases a(CHEBI:amyloid-beta) |
| pubmed:30116051 | a(CHEBI:resveratrol) decreases p(HGNC:HTT) |
| pubmed:30116051 | a(CHEBI:resveratrol) increases act(p(FPLX:AMPK)) |
| pubmed:30116051 | a(CHEBI:resveratrol) decreases act(a(MESH:"amyloid beta-protein (25-35)")) |
| pubmed:30116051 | a(CHEBI:resveratrol) increases p(FPLX:ATG4) |
| pubmed:30116051 | a(CHEBI:resveratrol) increases bp(GO:"autophagosome assembly") |
| pubmed:30116051 | a(CHEBI:resveratrol) decreases p(HGNC:AGER) |
| pubmed:30116051 | a(CHEBI:resveratrol) decreases p(HGNC:MMP9) |
| pubmed:29062069 | a(CHEBI:resveratrol) decreases p(HGNC:MID1) |
| pubmed:29062069 | a(CHEBI:resveratrol) increases act(p(HGNC:PPP2CA)) |
| pubmed:29062069 | a(CHEBI:resveratrol) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27288790 | act(p(FPLX:"IKK_complex")) increases p(FPLX:IKB, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23702978 | act(p(HGNC:STAT1)) increases act(p(HGNC:SCAF11)) |
| pubmed:23178521 | p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) association a(CHEBI:nicotine) |
| pubmed:30967783 | a(CHEBI:"prostaglandin E2") increases p(HGNC:TGFB1, loc(MESH:Neuroglia)) |
| pubmed:30967783 | a(CHEBI:"prostaglandin E2") increases p(HGNC:TGFB1, loc(MESH:Neurons)) |
| pubmed:30967783 | a(CHEBI:"prostaglandin E2") increases path(EFO:"experimental autoimmune encephalomyelitis") |
| pubmed:29179999 | a(CHEBI:pterostilbene) regulates p(HGNC:PPARA) |
| pubmed:29179999 | a(CHEBI:pterostilbene) regulates r(FPLX:NFkappaB) |
| pubmed:29179999 | a(CHEBI:pterostilbene) regulates p(FPLX:JNK, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21718217 | p(HGNC:PPARA) regulates bp(GO:"lipid oxidation") |
| pubmed:21718217 | p(HGNC:PPARA) regulates bp(MESH:"Lipid Peroxidation") |
| pubmed:22110360 | p(FPLX:JNK, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(FPLX:JNK)) |
| pubmed:18494933 | p(FPLX:JNK, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(FPLX:JNK)) |
| pubmed:18494933 | p(FPLX:JNK, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation act(p(HGNC:AGER)) |
| pubmed:18494933 | p(FPLX:JNK, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(HGNC:MAPK8)) |
| pubmed:22110360 | act(p(FPLX:JNK)) increases bp(GO:"stress-activated protein kinase signaling cascade") |
| pubmed:18494933 | act(p(FPLX:JNK)) increases p(HGNC:DKK1) |
| pubmed:18494933 | act(p(FPLX:JNK)) increases p(HGNC:DKK1) |
| pubmed:27068745 | act(p(FPLX:JNK)) positiveCorrelation p(ECCODE:1.6.3.1) |
| pubmed:27068745 | act(p(FPLX:JNK)) association p(HGNC:CASP3) |
| pubmed:29179999 | a(PUBCHEM:44584733) decreases r(HGNC:PTGS2) |
| pubmed:29179999 | a(PUBCHEM:44584733) decreases act(p(FPLX:NFkappaB), ma(GO:"DNA binding")) |
| pubmed:29179999 | a(PUBCHEM:44584733) decreases bp(GO:"inflammatory response") |
| pubmed:27288790 | r(HGNC:PTGS2) increases path(MESH:Inflammation) |
| pubmed:29179999 | a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") decreases bp(GO:"NIK/NF-kappaB signaling") |
| pubmed:29179999 | a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") increases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29179999 | a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") increases p(HGNC:MAPK14, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29179999 | a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") increases p(FPLX:ERK, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27288790 | p(HGNC:MAPK14) increases act(p(FPLX:NFkappaB)) |
| pubmed:27288790 | act(p(HGNC:MAPK14)) increases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27288790 | act(p(HGNC:MAPK14)) increases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27288790 | act(p(HGNC:MAPK14)) increases tloc(p(HGNC:RELA), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pubmed:15601849 | act(p(HGNC:MAPK14), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30640040 | act(p(HGNC:MAPK14)) increases a(CONSO:"Tau aggregates") |
| pubmed:23531502 | act(p(HGNC:MAPK14)) association a(CONSO:"Tau aggregates") |
| pubmed:30640040 | p(HGNC:MAPK14) association a(PUBCHEM:11570805) |
| pubmed:30640040 | p(HGNC:MAPK14) association a(PUBCHEM:156422) |
| pubmed:30640040 | p(HGNC:MAPK14) association a(PUBCHEM:10341154) |
| pubmed:11943212 | p(HGNC:MAPK14) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) |
| pubmed:27594586 | p(FPLX:ERK, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation act(p(HGNC:MMP9)) |
| pubmed:27594586 | p(FPLX:ERK, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation tloc(p(HGNC:MMP9), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:29121589 | p(FPLX:ERK, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(FPLX:ERK)) |
| pubmed:29179999 | a(CHEBI:Salidroside) increases bp(GO:cognition) |
| pubmed:29179999 | a(CHEBI:Salidroside) regulates p(HGNC:TXN) |
| pubmed:29179999 | a(CHEBI:Salidroside) regulates p(HGNC:TXNIP) |
| pubmed:29179999 | a(CHEBI:Salidroside) regulates p(HGNC:RELA) |
| pubmed:29179999 | a(CHEBI:Salidroside) regulates p(HGNC:NFKBIA) |
| pubmed:29179999 | a(CHEBI:Salidroside) regulates p(HGNC:CHUK) |
| pubmed:29179999 | a(CHEBI:Salidroside) regulates p(HGNC:IKBKB) |
| pubmed:30962309 | p(HGNC:TXNIP) increases p(HGNC:NLRP3) |
| pubmed:30962309 | p(HGNC:TXNIP) increases p(HGNC:NLRP3) |
| pubmed:26551702 | act(p(HGNC:IKBKB)) increases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29179999 | a(PUBCHEM:155160) increases bp(GO:memory) |
| pubmed:29179999 | a(PUBCHEM:155160) decreases a(CONSO:"amyloid-beta aggregates") |
| pubmed:29179999 | a(PUBCHEM:155160) decreases path(MESH:"Oxidative Stress") |
| pubmed:29179999 | a(PUBCHEM:155160) decreases path(MESH:Inflammation) |
| pubmed:29179999 | a(PUBCHEM:155160) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:29179999 | a(PUBCHEM:155160) decreases act(p(FPLX:"Gamma_secretase")) |
| pubmed:29179999 | a(PUBCHEM:155160) decreases act(p(HGNC:BACE1)) |
| pubmed:29179999 | a(PUBCHEM:155160) decreases act(p(FPLX:NFkappaB)) |
| pubmed:27288790 | a(CONSO:"amyloid-beta aggregates") increases act(p(FPLX:"IKK_complex")) |
| pubmed:27288790 | a(CONSO:"amyloid-beta aggregates") association p(HGNC:PTGS2) |
| pubmed:30444369 | a(CONSO:"amyloid-beta aggregates") increases path(CONSO:"mitochondrial dysfunction") |
| pubmed:30444369 | a(CONSO:"amyloid-beta aggregates") decreases act(p(FPLX:COX)) |
| pubmed:19293145 | a(CONSO:"amyloid-beta aggregates") association path(MESH:"Alzheimer Disease") |
| pubmed:19293145 | a(CONSO:"amyloid-beta aggregates") increases path(MESH:"Alzheimer Disease") |
| pubmed:24590577 | a(CONSO:"amyloid-beta aggregates") increases path(MESH:"Alzheimer Disease") |
| pubmed:25514383 | a(CONSO:"amyloid-beta aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22817713 | a(CONSO:"amyloid-beta aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24511233 | a(CONSO:"amyloid-beta aggregates") association path(MESH:"Plaque, Amyloid") |
| pubmed:24590577 | a(CONSO:"amyloid-beta aggregates") increases path(MESH:"Plaque, Amyloid") |
| pubmed:26195256 | a(CONSO:"amyloid-beta aggregates") association path(MESH:"Plaque, Amyloid") |
| pubmed:17009926 | a(CONSO:"amyloid-beta aggregates") association p(HGNC:CHRNA7) |
| pubmed:30697142 | a(CONSO:"amyloid-beta aggregates") directlyIncreases path(CONSO:neurotoxicity) |
| pubmed:21861815 | a(CONSO:"amyloid-beta aggregates") increases bp(GO:"neuron death") |
| pubmed:21722302 | a(CONSO:"amyloid-beta aggregates") association path(CONSO:Neurodegeneration) |
| pubmed:27491084 | a(CONSO:"amyloid-beta aggregates") association p(HGNC:HSPB1) |
| pubmed:27491084 | a(CONSO:"amyloid-beta aggregates") association p(HGNC:CRYAB) |
| pubmed:27491084 | a(CONSO:"amyloid-beta aggregates") association p(HGNC:HSPB6) |
| pubmed:27491084 | a(CONSO:"amyloid-beta aggregates") association p(HGNC:HSPB8) |
| pubmed:28877763 | a(CONSO:"amyloid-beta aggregates") positiveCorrelation p(MGI:Syk, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28877763 | a(CONSO:"amyloid-beta aggregates") positiveCorrelation act(p(MGI:Syk)) |
| pubmed:28877763 | a(CONSO:"amyloid-beta aggregates") positiveCorrelation act(p(HGNC:SYK)) |
| pubmed:26195256 | a(CONSO:"amyloid-beta aggregates") association path(MESH:"Cerebral Amyloid Angiopathy") |
| pubmed:26195256 | a(CONSO:"amyloid-beta aggregates", loc(GO:"extracellular region")) negativeCorrelation a(CHEBI:"amyloid-beta polypeptide 42", loc(MESH:"Cerebrospinal Fluid")) |
| pubmed:26195256 | a(CONSO:"amyloid-beta aggregates") decreases a(MESH:"Cerebrospinal Fluid") |
| pubmed:29179999 | a(CHEBI:"amyloid-beta polypeptide 42") association bp(GO:memory) |
| pubmed:29179999 | a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"neuron death") |
| pubmed:27288790 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(FPLX:IKB, pmod(go:0006468 ! "protein phosphorylation", Ser, 32)) |
| pubmed:27288790 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(FPLX:IKB, pmod(go:0006468 ! "protein phosphorylation", Ser, 36)) |
| pubmed:27288790 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(FPLX:NFkappaB, pmod(go:0006468 ! "protein phosphorylation", Ser, 536)) |
| pubmed:27288790 | a(CHEBI:"amyloid-beta polypeptide 42") increases r(HGNC:BACE1) |
| pubmed:27288790 | a(CHEBI:"amyloid-beta polypeptide 42") increases r(HGNC:BACE1-AS) |
| pubmed:25652642 | a(CHEBI:"amyloid-beta polypeptide 42") regulates p(HGNC:APP) |
| pubmed:25652642 | a(CHEBI:"amyloid-beta polypeptide 42") regulates p(HGNC:BACE1) |
| pubmed:25652642 | a(CHEBI:"amyloid-beta polypeptide 42") increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:25652642 | a(CHEBI:"amyloid-beta polypeptide 42") increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:25652642 | a(CHEBI:"amyloid-beta polypeptide 42") increases complex(p(HGNC:NFKB1), p(HGNC:NFKB1), p(HGNC:RELA), p(HGNC:RELA)) |
| pubmed:25652642 | a(CHEBI:"amyloid-beta polypeptide 42") regulates bp(GO:"cell death") |
| pubmed:25652642 | a(CHEBI:"amyloid-beta polypeptide 42") positiveCorrelation act(a(MESH:Microglia)) |
| pubmed:25652642 | a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"positive regulation of advanced glycation end-product receptor activity") |
| pubmed:25652642 | a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"peroxisome proliferator activated receptor signaling pathway") |
| pubmed:25652642 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(MESH:"I-kappa B Proteins", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29196815 | a(CHEBI:"amyloid-beta polypeptide 42") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19293145 | a(CHEBI:"amyloid-beta polypeptide 42") association path(MESH:"Alzheimer Disease") |
| pubmed:19126755 | a(CHEBI:"amyloid-beta polypeptide 42") association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19126755 | a(CHEBI:"amyloid-beta polypeptide 42") regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19293145 | a(CHEBI:"amyloid-beta polypeptide 42") increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19126755 | a(CHEBI:"amyloid-beta polypeptide 42") increases complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) |
| pubmed:19126755 | a(CHEBI:"amyloid-beta polypeptide 42") decreases complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA7)) |
| pubmed:19126755 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(HGNC:CHRNA7)) |
| pubmed:19126755 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:25514383 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:19126755 | a(CHEBI:"amyloid-beta polypeptide 42") decreases r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:25514383 | a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:"Synaptic Potentials") |
| pubmed:25514383 | a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:"Synaptic Potentials") |
| pubmed:25514383 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:CHRN)) |
| pubmed:25514383 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:CHRN)) |
| pubmed:25514383 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:25514383 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:25514383 | a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"long-term synaptic potentiation") |
| pubmed:19721446 | a(CHEBI:"amyloid-beta polypeptide 42") increases path(CONSO:neurotoxicity) |
| pubmed:19721446 | a(CHEBI:"amyloid-beta polypeptide 42") increases path(CONSO:neurotoxicity) |
| pubmed:22908190 | a(CHEBI:"amyloid-beta polypeptide 42") positiveCorrelation path(CONSO:neurotoxicity) |
| pubmed:22908190 | a(CHEBI:"amyloid-beta polypeptide 42") increases path(CONSO:neurotoxicity) |
| pubmed:19721446 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(CHEBI:nicotine)) |
| pubmed:19721446 | a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:Neuroprotection) |
| pubmed:31413141 | a(CHEBI:"amyloid-beta polypeptide 42") negativeCorrelation g(HGNC:APOE) |
| pubmed:14556719 | a(CHEBI:"amyloid-beta polypeptide 42") increases a(CONSO:"amyloid-beta fibrils") |
| pubmed:22908190 | tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) positiveCorrelation bp(GO:endocytosis) |
| pubmed:22908190 | tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) positiveCorrelation g(CONSO:"APOE e4") |
| pubmed:22908190 | tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) positiveCorrelation a(CHEBI:"low-density lipoprotein cholesterol") |
| pubmed:22908190 | a(CHEBI:"amyloid-beta polypeptide 42") positiveCorrelation tloc(a(CHEBI:amyloid-beta), fromLoc(GO:cytosol), toLoc(GO:autolysosome)) |
| pubmed:26195256 | a(CHEBI:"amyloid-beta polypeptide 42") isA a(CHEBI:amyloid-beta) |
| pubmed:30116051 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:AMPK)) |
| pubmed:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") causesNoChange p(FPLX:AMPK) |
| pubmed:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:AMPK)) |
| pubmed:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:AMPK)) |
| pubmed:30116051 | a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"autophagosome assembly") |
| pubmed:30116051 | a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:30116051 | a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"chaperone-mediated autophagy") |
| pubmed:30116051 | a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"chaperone-mediated autophagy") |
| pubmed:30116051 | a(CHEBI:"amyloid-beta polypeptide 42") decreases a(GO:microtubule) |
| pubmed:30116051 | a(CHEBI:"amyloid-beta polypeptide 42") decreases p(HGNC:IDE) |
| pubmed:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:AK1) |
| pubmed:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:AK1) |
| pubmed:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") causesNoChange act(p(HGNC:AK3)) |
| pubmed:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases r(HGNC:AK1) |
| pubmed:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 231)) |
| pubmed:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 235)) |
| pubmed:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") decreases p(FPLX:AMPK, pmod(go:0006468 ! "protein phosphorylation", Thr, 172)) |
| pubmed:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") decreases p(FPLX:AMPK, pmod(go:0006468 ! "protein phosphorylation", Thr, 172)) |
| pubmed:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") decreases p(MESH:"Acetyl-CoA Carboxylase", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") decreases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:26195256 | a(CHEBI:"amyloid-beta polypeptide 42", loc(MESH:"Cerebrospinal Fluid")) negativeCorrelation a(CONSO:"amyloid-beta aggregates", loc(GO:"extracellular region")) |
| pubmed:29626319 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:TREM2) |
| pubmed:30444369 | p(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta polypeptide 42"), p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments"))) |
| pubmed:26195256 | p(FPLX:"Gamma_secretase") increases deg(p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments")) |
| pubmed:29179999 | a(CHEBI:lycopene) increases path(MESH:"Spatial Learning") |
| pubmed:29179999 | a(CHEBI:lycopene) increases bp(GO:memory) |
| pubmed:29179999 | a(CHEBI:lycopene) decreases bp(GO:"NIK/NF-kappaB signaling") |
| pubmed:29179999 | a(CHEBI:lycopene) decreases a(MESH:Cytokines) |
| pubmed:29179999 | a(CHEBI:genistein) decreases p(HGNC:TLR4) |
| pubmed:29179999 | a(CHEBI:genistein) decreases p(FPLX:NFkappaB) |
| pubmed:29179999 | a(CHEBI:genistein) decreases act(p(FPLX:NFkappaB), ma(GO:"DNA binding")) |
| pubmed:29179999 | a(CHEBI:genistein) decreases act(p(FPLX:NFkappaB)) |
| pubmed:19293145 | a(CHEBI:genistein) decreases act(a(CHEBI:amyloid-beta)) |
| pubmed:19293145 | a(CHEBI:genistein) decreases act(a(CHEBI:"L-glutamate(2-)")) |
| pubmed:19293145 | a(CHEBI:genistein) decreases p(HGNC:CHRNA7, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:17009926 | a(CHEBI:genistein) decreases p(HGNC:CHRNA7, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:17009926 | a(CHEBI:genistein) causesNoChange tloc(p(FPLX:CHRN), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) |
| pubmed:17009926 | a(CHEBI:genistein) regulates p(FPLX:CHRN) |
| pubmed:27299292 | a(CHEBI:genistein) decreases path(DOID:mucopolysaccharidosis) |
| pubmed:27299292 | a(CHEBI:genistein) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) |
| pubmed:30962309 | p(HGNC:TLR4) increases p(HGNC:MYD88) |
| pubmed:26979166 | act(p(HGNC:TLR4)) increases r(MESH:Cytokines) |
| pubmed:27314526 | p(HGNC:TLR4) increases bp(GO:"cytokine secretion") |
| pubmed:30988501 | p(HGNC:TLR4) biomarkerFor path(CONSO:neuroinflammation) |
| pubmed:30988501 | p(HGNC:TLR4) biomarkerFor path(CONSO:Neurodegeneration) |
| pubmed:29179999 | a(PUBCHEM:45270574) decreases act(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pubmed:29179999 | a(CHEBI:"gallic acid") decreases act(p(FPLX:MYST)) |
| pubmed:29179999 | a(CHEBI:"gallic acid") decreases p(HGNC:RELA, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:29179999 | a(CHEBI:"gallic acid") decreases path(MESH:Inflammation) |
| pubmed:29179999 | a(CHEBI:"gallic acid") decreases act(p(FPLX:NFkappaB)) |
| pubmed:29179999 | a(CHEBI:"gallic acid") decreases act(a(CHEBI:amyloid-beta)) |
| pubmed:29179999 | p(HGNC:RELA, pmod(go:0006473 ! "protein acetylation")) association path(MESH:"Neurotoxicity Syndromes") |
| pubmed:29179999 | path(MESH:"Neurotoxicity Syndromes") association p(HGNC:RELA, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30515821 | path(MESH:"Neurotoxicity Syndromes") increases bp(GO:"programmed cell death") |
| pubmed:29179999 | a(CHEBI:galanthamine) decreases act(p(HGNC:ACHE)) |
| pubmed:19126755 | a(CHEBI:galanthamine) decreases p(HGNC:ACHE) |
| pubmed:19293145 | a(CHEBI:galanthamine) decreases act(p(HGNC:ACHE)) |
| pubmed:11230871 | a(CHEBI:galanthamine) decreases act(p(HGNC:ACHE)) |
| pubmed:29179999 | a(CHEBI:galanthamine) increases a(CHEBI:acetylcholine) |
| pubmed:29179999 | a(CHEBI:galanthamine) increases tloc(a(CHEBI:acetylcholine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:29179999 | a(CHEBI:galanthamine) increases a(MESH:"Cholinergic Agents") |
| pubmed:29179999 | a(CHEBI:galanthamine) increases act(p(HGNC:HMOX1)) |
| pubmed:29179999 | a(CHEBI:galanthamine) increases act(p(FPLX:NFkappaB)) |
| pubmed:30444369 | a(CHEBI:galanthamine) increases bp(GO:cognition) |
| pubmed:26813123 | a(CHEBI:galanthamine) increases bp(GO:cognition) |
| pubmed:30444369 | a(CHEBI:galanthamine) decreases act(p(FPLX:Cholinesterase)) |
| pubmed:19126755 | a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19126755 | a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19126755 | a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19126755 | a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19293145 | a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19126755 | a(CHEBI:galanthamine) decreases path(CONSO:Neurodegeneration) |
| pubmed:19126755 | a(CHEBI:galanthamine) increases bp(GO:"synaptic transmission, cholinergic") |
| pubmed:19293145 | a(CHEBI:galanthamine) isA a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") |
| pubmed:19293145 | a(CHEBI:galanthamine) decreases path(MESH:"Alzheimer Disease") |
| pubmed:19293145 | act(a(CHEBI:galanthamine)) increases bp(MESH:Neuroprotection) |
| pubmed:19293145 | a(CHEBI:galanthamine) increases p(HGNC:BCL2) |
| pubmed:24511233 | a(CHEBI:galanthamine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") |
| pubmed:17009926 | a(CHEBI:galanthamine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") |
| pubmed:17009926 | a(CHEBI:galanthamine) increases act(p(FPLX:CHRN)) |
| pubmed:11230871 | a(CHEBI:galanthamine) increases act(p(FPLX:CHRN)) |
| pubmed:11230871 | a(CHEBI:galanthamine) increases p(FPLX:CHRN) |
| pubmed:26813123 | a(CHEBI:galanthamine) decreases path(MESH:Death) |
| pubmed:25881725 | a(CHEBI:galanthamine) decreases act(p(MGI:App, frag("25_35"))) |
| pubmed:25881725 | a(CHEBI:galanthamine) increases bp(GO:learning) |
| pubmed:25881725 | a(CHEBI:galanthamine) increases path(MESH:"Spatial Memory") |
| pubmed:25881725 | a(CHEBI:galanthamine) causesNoChange r(MGI:Chrna7) |
| pubmed:25881725 | a(CHEBI:galanthamine) increases p(MGI:Chrna7) |
| pubmed:25881725 | a(CHEBI:galanthamine) increases p(MGI:Chrna7) |
| pubmed:19721446 | a(CHEBI:galanthamine) regulates p(HGNC:CHRNA7) |
| pubmed:19721446 | a(CHEBI:galanthamine) decreases path(MESH:Schizophrenia) |
| pubmed:29179999 | complex(a(CHEBI:galanthamine), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) |
| pubmed:17009926 | p(FPLX:CHRN) increases bp(GO:"neurotransmitter secretion") |
| pubmed:17009926 | act(p(FPLX:CHRN)) increases bp(GO:"neurotransmitter secretion") |
| pubmed:17009926 | p(FPLX:CHRN) increases bp(GO:"neurotransmitter secretion") |
| pubmed:17009926 | p(FPLX:CHRN) regulates bp(GO:"rhythmic excitation") |
| pubmed:17009926 | p(FPLX:CHRN) regulates bp(GO:"rhythmic excitation") |
| pubmed:17009926 | p(FPLX:CHRN) regulates bp(GO:"neuron remodeling") |
| pubmed:17009926 | p(FPLX:CHRN) association bp(GO:"regulation of synaptic plasticity") |
| pubmed:17009926 | act(p(FPLX:CHRN)) increases bp(GO:"regulation of synaptic plasticity") |
| pubmed:17009926 | p(FPLX:CHRN) association bp(GO:"regulation of synaptic plasticity") |
| pubmed:17009926 | p(FPLX:CHRN) association path(MESH:Attention) |
| pubmed:17009926 | p(FPLX:CHRN) association bp(GO:learning) |
| pubmed:17009926 | p(FPLX:CHRN) association bp(GO:memory) |
| pubmed:11230871 | p(FPLX:CHRN) association bp(GO:memory) |
| pubmed:17009926 | p(FPLX:CHRN) association bp(GO:"developmental process") |
| pubmed:17009926 | p(FPLX:CHRN) association path(MESH:Schizophrenia) |
| pubmed:17009926 | p(FPLX:CHRN) association path(MESH:Schizophrenia) |
| pubmed:21482353 | act(p(FPLX:CHRN)) association path(MESH:Schizophrenia) |
| pubmed:11230871 | p(FPLX:CHRN) association path(MESH:Schizophrenia) |
| pubmed:17009926 | p(FPLX:CHRN) association path(MESH:Epilepsy) |
| pubmed:17009926 | p(FPLX:CHRN) association path(MESH:Epilepsy) |
| pubmed:11230871 | p(FPLX:CHRN) association path(MESH:Epilepsy) |
| pubmed:17009926 | p(FPLX:CHRN) association path(MESH:"Autistic Disorder") |
| pubmed:17009926 | act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Autistic Disorder") |
| pubmed:17009926 | p(FPLX:CHRN) negativeCorrelation path(MESH:"Autistic Disorder") |
| pubmed:17009926 | p(FPLX:CHRN) association path(MESH:"Alzheimer Disease") |
| pubmed:17009926 | act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:17009926 | p(FPLX:CHRN) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:17009926 | p(FPLX:CHRN) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:11230871 | p(FPLX:CHRN) association path(MESH:"Alzheimer Disease") |
| pubmed:11230871 | p(FPLX:CHRN) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:17009926 | p(FPLX:CHRN) association path(MESH:"Behavior, Addictive") |
| pubmed:26472524 | act(p(FPLX:CHRN)) increases path(MESH:"Behavior, Addictive") |
| pubmed:17009926 | p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:17009926 | p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pubmed:26472524 | p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:26472524 | p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pubmed:17009926 | p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:17009926 | p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pubmed:26472524 | p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:26472524 | p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pubmed:17009926 | act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") |
| pubmed:17009926 | act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") |
| pubmed:17009926 | act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") |
| pubmed:26472524 | act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") |
| pubmed:17009926 | act(p(FPLX:CHRN)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:26472524 | p(FPLX:CHRN) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:26472524 | p(FPLX:CHRN) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pubmed:25514383 | act(p(FPLX:CHRN)) increases a(CHEBI:"calcium(2+)") |
| pubmed:17009926 | act(p(FPLX:CHRN)) increases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17009926 | p(FPLX:CHRN) increases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:26472524 | act(p(FPLX:CHRN)) increases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17009926 | p(FPLX:CHRN) increases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17009926 | p(FPLX:CHRN) regulates act(complex(GO:"GABA-A receptor complex")) |
| pubmed:17009926 | act(p(FPLX:CHRN)) increases bp(GO:"long term synaptic depression") |
| pubmed:17009926 | act(p(FPLX:CHRN)) increases bp(GO:"regulation of action potential firing rate") |
| pubmed:17009926 | p(FPLX:CHRN) association bp(GO:"regulation of action potential firing rate") |
| pubmed:17009926 | p(FPLX:CHRN) increases bp(GO:"regulation of action potential firing rate") |
| pubmed:17009926 | p(FPLX:CHRN) association bp(GO:"regulation of action potential firing pattern") |
| pubmed:17009926 | act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Lewy Body Disease") |
| pubmed:17009926 | p(FPLX:CHRN) negativeCorrelation path(MESH:"Lewy Body Disease") |
| pubmed:17009926 | act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Down Syndrome") |
| pubmed:17009926 | p(FPLX:CHRN) negativeCorrelation path(MESH:"Down Syndrome") |
| pubmed:17009926 | act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Parkinson Disease") |
| pubmed:17009926 | p(FPLX:CHRN) negativeCorrelation path(MESH:"Parkinson Disease") |
| pubmed:11230871 | p(FPLX:CHRN) association path(MESH:"Parkinson Disease") |
| pubmed:17009926 | p(FPLX:CHRN) association bp(GO:"response to pain") |
| pubmed:17009926 | p(FPLX:CHRN) association path(MESH:Anxiety) |
| pubmed:11230871 | p(FPLX:CHRN) association path(MESH:Anxiety) |
| pubmed:17009926 | p(FPLX:CHRN) association path(MESH:Depression) |
| pubmed:11230871 | p(FPLX:CHRN) association path(MESH:Depression) |
| pubmed:17009926 | act(p(FPLX:CHRN)) increases path(MESH:Arousal) |
| pubmed:28445721 | p(FPLX:CHRN) association path(MESH:Arousal) |
| pubmed:17009926 | act(p(FPLX:CHRN)) increases bp(GO:"circadian sleep/wake cycle, REM sleep") |
| pubmed:26472524 | p(FPLX:CHRN) increases tloc(a(CHEBI:"sodium(1+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:26472524 | p(FPLX:CHRN) increases tloc(a(CHEBI:"sodium(1+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pubmed:26472524 | p(FPLX:CHRN) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:26472524 | p(FPLX:CHRN) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pubmed:26813123 | p(FPLX:CHRN) increases bp(GO:cognition) |
| pubmed:25514383 | p(FPLX:CHRN) regulates bp(GO:cognition) |
| pubmed:28445721 | p(FPLX:CHRN) association bp(GO:cognition) |
| pubmed:28445721 | p(FPLX:CHRN) association bp(GO:cognition) |
| pubmed:28445721 | p(FPLX:CHRN) association bp(GO:cognition) |
| pubmed:11230871 | p(FPLX:CHRN) association bp(GO:cognition) |
| pubmed:26813123 | p(FPLX:CHRN) decreases path(CONSO:Neurodegeneration) |
| pubmed:25514383 | p(FPLX:CHRN) isA a(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors") |
| pubmed:25514383 | p(FPLX:CHRN) regulates bp(GO:"potassium ion transport") |
| pubmed:25514383 | p(FPLX:CHRN) regulates bp(GO:"sodium ion transport") |
| pubmed:25514383 | p(FPLX:CHRN) regulates bp(GO:"calcium ion transport") |
| pubmed:25514383 | act(p(FPLX:CHRN)) increases bp(MESH:"Synaptic Potentials") |
| pubmed:25514383 | p(FPLX:CHRN) regulates path(MESH:"Cognition Disorders") |
| pubmed:28445721 | p(FPLX:CHRN) association path(MESH:Motivation) |
| pubmed:28445721 | act(p(FPLX:CHRN)) increases act(a(MESH:"Dopaminergic Neurons")) |
| pubmed:28445721 | p(FPLX:CHRN) increases bp(GO:"positive regulation of synaptic plasticity") |
| pubmed:28445721 | p(FPLX:CHRN) increases bp(GO:"dopamine secretion") |
| pubmed:28445721 | p(FPLX:CHRN) association path(MESH:"Tobacco Use Disorder") |
| pubmed:21482353 | act(p(FPLX:CHRN)) association path(MESH:"Tobacco Use Disorder") |
| pubmed:21482353 | p(FPLX:CHRN) increases tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pubmed:11230871 | act(p(FPLX:CHRN)) regulates tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pubmed:21482353 | act(p(FPLX:CHRN)) association complex(p(FPLX:CHRN), p(HGNC:LYNX1)) |
| pubmed:21482353 | tloc(p(FPLX:CHRN), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) association complex(p(FPLX:CHRN), p(HGNC:LYNX1)) |
| pubmed:21482353 | p(FPLX:CHRN) regulates p(HGNC:LYNX1) |
| pubmed:21482353 | act(p(FPLX:CHRN)) negativeCorrelation act(a(MESH:Brain)) |
| pubmed:21482353 | act(p(FPLX:CHRN)) negativeCorrelation a(MESH:Neurons) |
| pubmed:21482353 | p(FPLX:CHRN) regulates bp(GO:"GABAergic neuron differentiation") |
| pubmed:21482353 | p(FPLX:CHRN) increases act(a(HP:"inhibitory interneuron")) |
| pubmed:21482353 | p(FPLX:CHRN) increases act(p(FPLX:NOS)) |
| pubmed:11230871 | p(FPLX:CHRN) association a(MESH:"Neurotransmitter Agents") |
| pubmed:11230871 | p(FPLX:CHRN) association path(MESH:"Tourette Syndrome") |
| pubmed:11230871 | p(FPLX:CHRN) negativeCorrelation path(MESH:"Cognitive Dysfunction") |
| pubmed:11230871 | p(FPLX:CHRN) negativeCorrelation p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) |
| pubmed:11230871 | p(FPLX:CHRN) negativeCorrelation a(MESH:"Amyloid beta-Peptides") |
| pubmed:11230871 | p(FPLX:CHRN) negativeCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:11230871 | p(FPLX:CHRN) negativeCorrelation bp(GO:"response to oxidative stress") |
| pubmed:21787755 | p(FPLX:CHRN) increases bp(GO:"maintenance of synapse structure") |
| pubmed:21787755 | p(FPLX:CHRN) increases bp(GO:"neuron projection maintenance") |
| pubmed:27190210 | p(HGNC:HMOX1) decreases path(MESH:Inflammation) |
| pubmed:28148553 | p(HGNC:HMOX1) regulates bp(GO:"iron ion homeostasis") |
| pubmed:29179999 | a(PUBCHEM:14193399) decreases a(CHEBI:"nitric oxide") |
| pubmed:29179999 | a(PUBCHEM:14193399) decreases p(HGNC:TNF) |
| pubmed:29179999 | a(PUBCHEM:14193399) decreases p(HGNC:IL1A) |
| pubmed:29179999 | a(PUBCHEM:14193399) decreases p(HGNC:PTGS2) |
| pubmed:29179999 | a(PUBCHEM:14193399) decreases p(HGNC:NOS2) |
| pubmed:29179999 | a(PUBCHEM:14193399) decreases act(p(FPLX:NFkappaB)) |
| pubmed:29179999 | a(PUBCHEM:14193399) decreases act(p(HGNC:MAPK14)) |
| pubmed:29179999 | a(PUBCHEM:14193399) decreases a(CHEBI:"reactive oxygen species") |
| pubmed:29179999 | a(PUBCHEM:73078) decreases act(p(FPLX:NFkappaB)) |
| pubmed:29179999 | a(PUBCHEM:73078) decreases act(p(FPLX:NFkappaB)) |
| pubmed:29179999 | a(PUBCHEM:73078) decreases a(MESH:Cytokines) |
| pubmed:29179999 | a(PUBCHEM:73078) decreases deg(p(HGNC:NFKBIA)) |
| pubmed:29179999 | a(PUBCHEM:73078) decreases tloc(p(HGNC:RELA), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pubmed:29179999 | a(PUBCHEM:73078) decreases act(p(HGNC:CHUK)) |
| pubmed:29179999 | a(PUBCHEM:73078) decreases act(p(HGNC:IKBKB)) |
| pubmed:29179999 | a(PUBCHEM:73078) increases path(MESH:"Spatial Learning") |
| pubmed:29179999 | a(PUBCHEM:73078) increases bp(GO:memory) |
| pubmed:29179999 | a(PUBCHEM:73078) decreases p(HGNC:IL1B) |
| pubmed:29179999 | a(PUBCHEM:73078) decreases r(HGNC:TNF) |
| pubmed:27288790 | r(HGNC:TNF) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pubmed:29179999 | a(CHEBI:berberine) decreases path(MESH:Inflammation) |
| pubmed:29179999 | a(CHEBI:berberine) decreases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29179999 | a(CHEBI:berberine) decreases r(HGNC:RELA) |
| pubmed:29179999 | a(CHEBI:berberine) decreases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29179999 | a(CHEBI:berberine) decreases act(p(HGNC:MAPK14)) |
| pubmed:29179999 | a(CHEBI:berberine) decreases act(p(FPLX:ERK)) |
| pubmed:29179999 | a(CHEBI:berberine) decreases act(p(FPLX:AKT)) |
| pubmed:26551702 | p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) regulates complex(a(MESH:DNA), p(HGNC:RELA)) |
| pubmed:29179999 | a(CHEBI:oridonin) decreases act(p(FPLX:NFkappaB)) |
| pubmed:29179999 | a(CHEBI:oridonin) increases bp(GO:cognition) |
| pubmed:29179999 | a(CHEBI:oridonin) decreases path(MESH:Inflammation) |
| pubmed:29179999 | a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) |
| pubmed:22807490 | a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) |
| pubmed:26010758 | a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) |
| pubmed:26010758 | a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) |
| pubmed:26010758 | a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) |
| pubmed:29179999 | a(CHEBI:Anatabine) decreases a(CHEBI:amyloid-beta) |
| pubmed:21958873 | a(CHEBI:Anatabine) decreases a(CHEBI:amyloid-beta) |
| pubmed:21958873 | a(CHEBI:Anatabine) decreases a(CHEBI:amyloid-beta) |
| pubmed:26010758 | a(CHEBI:Anatabine) decreases a(CHEBI:amyloid-beta) |
| pubmed:29179999 | a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pubmed:21958873 | a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pubmed:21958873 | a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pubmed:21958873 | a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pubmed:29179999 | a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:21958873 | a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:21958873 | a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:21958873 | a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:22807490 | a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response") |
| pubmed:21958873 | a(CHEBI:Anatabine) negativeCorrelation bp(GO:"inflammatory response") |
| pubmed:23178521 | a(CHEBI:Anatabine) negativeCorrelation bp(GO:"inflammatory response") |
| pubmed:26010758 | a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response") |
| pubmed:26010758 | a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response") |
| pubmed:26010758 | a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response") |
| pubmed:22807490 | a(CHEBI:Anatabine) decreases path(MESH:"Thyroiditis, Autoimmune") |
| pubmed:22807490 | a(CHEBI:Anatabine) decreases a(MESH:Thyroglobulin) |
| pubmed:22807490 | a(CHEBI:Anatabine) decreases p(HGNC:IL1R2) |
| pubmed:22807490 | a(CHEBI:Anatabine) decreases p(HGNC:IL18) |
| pubmed:22807490 | a(CHEBI:Anatabine) decreases p(HGNC:NOS2) |
| pubmed:22807490 | a(CHEBI:Anatabine) decreases p(HGNC:PTGS2) |
| pubmed:22807490 | a(CHEBI:Anatabine) decreases bp(GO:"macrophage activation") |
| pubmed:21958873 | a(CHEBI:Anatabine) causesNoChange tloc(p(HGNC:LDHA), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21958873 | a(CHEBI:Anatabine) decreases tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21958873 | a(CHEBI:Anatabine) causesNoChange tloc(p(CONSO:sAPP-alpha), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21958873 | a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex")) |
| pubmed:21958873 | a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex")) |
| pubmed:21958873 | a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex")) |
| pubmed:21958873 | a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex")) |
| pubmed:21958873 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21958873 | a(CHEBI:Anatabine) decreases r(HGNC:BACE1) |
| pubmed:26010758 | a(CHEBI:Anatabine) decreases r(HGNC:BACE1) |
| pubmed:21958873 | a(CHEBI:Anatabine) decreases p(HGNC:BACE1) |
| pubmed:21958873 | a(CHEBI:Anatabine) decreases bp(GO:"amyloid-beta formation") |
| pubmed:21958873 | a(CHEBI:Anatabine) decreases p(HGNC:CRP) |
| pubmed:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26010758 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:Anatabine) decreases p(MGI:Tnf) |
| pubmed:23383175 | a(CHEBI:Anatabine) causesNoChange p(MGI:Tnf) |
| pubmed:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Tnf) |
| pubmed:23178521 | a(CHEBI:Anatabine) decreases p(MGI:Il6) |
| pubmed:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Il6) |
| pubmed:23383175 | a(CHEBI:Anatabine) decreases a(MESH:Cytokines) |
| pubmed:23383175 | a(CHEBI:Anatabine) increases bp(GO:"neuroinflammatory response") |
| pubmed:23383175 | a(CHEBI:Anatabine) negativeCorrelation path(MESH:Encephalomyelitis) |
| pubmed:23383175 | a(CHEBI:Anatabine) decreases path(MESH:Encephalomyelitis) |
| pubmed:23383175 | a(CHEBI:Anatabine) decreases path(MESH:Paralysis) |
| doi:"10.4172/2168-975X.1000126" | a(CHEBI:Anatabine) decreases path(MESH:Paralysis) |
| pubmed:23383175 | a(CHEBI:Anatabine) decreases path(HP:"Limb muscle weakness") |
| pubmed:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Il1b) |
| pubmed:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Il1b) |
| pubmed:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Il17a) |
| pubmed:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Il17a) |
| pubmed:23383175 | a(CHEBI:Anatabine) causesNoChange p(MGI:Ifng) |
| pubmed:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Ifng) |
| pubmed:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Rela, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Rela, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23383175 | a(CHEBI:Anatabine) causesNoChange bp(CONSO:Astrogliosis) |
| pubmed:23383175 | a(CHEBI:Anatabine) decreases bp(CONSO:Astrogliosis) |
| pubmed:23383175 | a(CHEBI:Anatabine) decreases bp(CONSO:Microgliosis) |
| doi:"10.4172/2168-975X.1000126" | a(CHEBI:Anatabine) decreases bp(CONSO:Microgliosis) |
| pubmed:23383175 | a(CHEBI:Anatabine) decreases tloc(a(MESH:Leukocytes), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) |
| pubmed:23383175 | a(CHEBI:Anatabine) decreases a(MESH:Microglia) |
| pubmed:23383175 | a(CHEBI:Anatabine) decreases tloc(a(MESH:Microglia), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) |
| pubmed:23383175 | a(CHEBI:Anatabine) decreases tloc(a(MESH:Macrophages), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) |
| pubmed:23383175 | a(CHEBI:Anatabine) positiveCorrelation a(GO:"myelin sheath") |
| doi:"10.4172/2168-975X.1000126" | a(CHEBI:Anatabine) increases bp(GO:"motor behavior") |
| doi:"10.4172/2168-975X.1000126" | a(CHEBI:Anatabine) increases bp(GO:"motor behavior") |
| doi:"10.4172/2168-975X.1000126" | a(CHEBI:Anatabine) decreases path(MESH:Anxiety) |
| pubmed:26010758 | a(CHEBI:Anatabine) decreases path(MESH:Anxiety) |
| doi:"10.4172/2168-975X.1000126" | a(CHEBI:Anatabine) causesNoChange path(MESH:"Spatial Learning") |
| doi:"10.4172/2168-975X.1000126" | a(CHEBI:Anatabine) causesNoChange p(HGNC:MAPT) |
| doi:"10.4172/2168-975X.1000126" | a(CHEBI:Anatabine) decreases act(p(HGNC:MAPT)) |
| doi:"10.4172/2168-975X.1000126" | a(CHEBI:Anatabine) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| doi:"10.4172/2168-975X.1000126" | a(CHEBI:Anatabine) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| doi:"10.4172/2168-975X.1000126" | a(CHEBI:Anatabine) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| doi:"10.4172/2168-975X.1000126" | a(CHEBI:Anatabine) decreases a(GO:"neurofibrillary tangle") |
| doi:"10.4172/2168-975X.1000126" | a(CHEBI:Anatabine) decreases a(CONSO:"Tau oligomers") |
| doi:"10.4172/2168-975X.1000126" | a(CHEBI:Anatabine) decreases a(CONSO:"Tau oligomers") |
| doi:"10.4172/2168-975X.1000126" | a(CHEBI:Anatabine) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| doi:"10.4172/2168-975X.1000126" | a(CHEBI:Anatabine) increases p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation", Ser, 473)) |
| pubmed:26010758 | a(CHEBI:Anatabine) decreases path(MESH:Gliosis) |
| pubmed:26010758 | a(CHEBI:Anatabine) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26010758 | a(CHEBI:Anatabine) increases act(p(HGNC:CHRNA7)) |
| pubmed:26010758 | a(CHEBI:Anatabine) decreases act(p(HGNC:STAT3)) |
| pubmed:26010758 | a(CHEBI:Anatabine) decreases act(p(HGNC:STAT3)) |
| pubmed:26010758 | a(CHEBI:Anatabine) decreases act(p(HGNC:STAT3)) |
| pubmed:26010758 | a(CHEBI:Anatabine) decreases bp(GO:locomotion) |
| pubmed:26010758 | a(CHEBI:Anatabine) increases path(MESH:"Interpersonal Relations") |
| pubmed:26010758 | a(CHEBI:Anatabine) decreases p(HGNC:AIF1) |
| pubmed:26010758 | a(CHEBI:Anatabine) decreases bp(GO:"microglial cell activation") |
| pubmed:26010758 | a(CHEBI:Anatabine) decreases p(HGNC:PTPRC) |
| pubmed:26010758 | a(CHEBI:Anatabine) decreases p(FPLX:NFkappaB, pmod(go:0006468 ! "protein phosphorylation", Ser, 536)) |
| pubmed:26010758 | a(CHEBI:Anatabine) decreases r(HGNC:PTGS2) |
| pubmed:26010758 | a(CHEBI:Anatabine) decreases r(HGNC:NOS2) |
| pubmed:29844403 | a(CHEBI:"amyloid-beta polypeptide 40") decreases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:29844403 | a(CHEBI:"amyloid-beta polypeptide 40") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:25514383 | a(CHEBI:"amyloid-beta polypeptide 40") decreases act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:25514383 | a(CHEBI:"amyloid-beta polypeptide 40") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:14556719 | a(CHEBI:"amyloid-beta polypeptide 40") increases a(CONSO:"amyloid-beta fibrils") |
| pubmed:26195256 | a(CHEBI:"amyloid-beta polypeptide 40") isA a(CHEBI:amyloid-beta) |
| pubmed:29179999 | a(CHEBI:"vitamin D") decreases p(FPLX:NFkappaB, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29179999 | a(CHEBI:"vitamin D") decreases a(CHEBI:"reactive oxygen species") |
| pubmed:29179999 | a(CHEBI:"vitamin D") decreases path(MESH:Inflammation) |
| pubmed:26445701 | a(CHEBI:"vitamin D") decreases path(DOID:"multiple sclerosis") |
| pubmed:26445701 | a(CHEBI:"vitamin D") regulates bp(MESH:Immunity) |
| pubmed:29179999 | a(CHEBI:alpha-tocopherol) decreases a(CHEBI:"reactive oxygen species") |
| pubmed:29179999 | a(CHEBI:alpha-tocopherol) decreases a(CHEBI:amyloid-beta) |
| pubmed:29179999 | a(CHEBI:alpha-tocopherol) decreases a(CHEBI:amyloid-beta) |
| pubmed:29179999 | a(CHEBI:alpha-tocopherol) decreases a(MESH:Cytokines) |
| pubmed:29179999 | a(CHEBI:alpha-tocopherol) decreases a(CHEBI:"nitric oxide") |
| pubmed:29179999 | a(CHEBI:alpha-tocopherol) increases bp(GO:memory) |
| pubmed:29179999 | a(CHEBI:alpha-tocopherol) decreases path(MESH:"Oxidative Stress") |
| pubmed:29179999 | a(CHEBI:alpha-tocopherol) decreases act(p(FPLX:NFkappaB)) |
| pubmed:29179999 | a(CHEBI:alpha-tocopherol) decreases p(HGNC:NOS2) |
| pubmed:29179999 | a(CHEBI:alpha-tocopherol) decreases p(HGNC:IL6) |
| pubmed:29179999 | a(CHEBI:alpha-tocopherol) decreases p(HGNC:IL1B) |
| pubmed:29179999 | a(CHEBI:alpha-tocopherol) decreases bp(GO:"microglial cell activation") |
| pubmed:14970312 | a(CHEBI:alpha-tocopherol) decreases bp(GO:"regulation of sphingomyelin catabolic process") |
| pubmed:27794524 | bp(GO:"microglial cell activation") association path(MESH:"Nerve Degeneration") |
| pubmed:27794524 | bp(GO:"microglial cell activation") association path(MESH:"Demyelinating Diseases") |
| pubmed:27794524 | bp(GO:"microglial cell activation") directlyIncreases a(MESH:Macrophages) |
| pubmed:27794524 | bp(GO:"microglial cell activation") decreases bp(GO:"compartment boundary maintenance") |
| pubmed:27794524 | bp(GO:"microglial cell activation") association path(MESH:Inflammation) |
| pubmed:27956442 | bp(GO:"microglial cell activation") directlyIncreases path(MESH:Inflammation) |
| pubmed:26979166 | bp(GO:"microglial cell activation") increases path(MESH:Inflammation) |
| pubmed:27794524 | bp(GO:"microglial cell activation") association path(MESH:"Autoimmune Diseases") |
| pubmed:27794524 | bp(GO:"microglial cell activation") decreases a(MESH:Oligodendroglia) |
| pubmed:27794524 | bp(GO:"microglial cell activation") increases tloc(p(HGNC:IL1A), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27794524 | bp(GO:"microglial cell activation") increases tloc(p(HGNC:IL6), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27314526 | bp(GO:"microglial cell activation") increases tloc(p(HGNC:IL6), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27794524 | bp(GO:"microglial cell activation") increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30967783 | bp(GO:"microglial cell activation") increases p(HGNC:TNF) |
| pubmed:27794524 | bp(GO:"microglial cell activation") increases tloc(p(HGNC:IFNG), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27794524 | bp(GO:"microglial cell activation") increases act(a(MESH:Phagocytes)) |
| pubmed:27794524 | bp(GO:"microglial cell activation") positiveCorrelation bp(GO:"regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II") |
| pubmed:27794524 | bp(GO:"microglial cell activation") increases path(MESH:Neuroprotection) |
| pubmed:27794524 | bp(GO:"microglial cell activation") increases path(MESH:Phagocytosis) |
| pubmed:27794524 | bp(GO:"microglial cell activation") increases bp(GO:"neuron remodeling") |
| pubmed:27794524 | bp(GO:"microglial cell activation") increases bp(GO:"monocyte migration into blood stream") |
| pubmed:27794524 | bp(GO:"microglial cell activation") increases path(MESH:"Neurodegenerative Diseases") |
| pubmed:30967783 | bp(GO:"microglial cell activation") increases composite(a(MESH:Microglia), a(MESH:Neurons)) |
| pubmed:30967783 | bp(GO:"microglial cell activation") increases bp(GO:"complement activation") |
| pubmed:30967783 | bp(GO:"microglial cell activation") increases tloc(a(MESH:Chemokines), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:26979166 | bp(GO:"microglial cell activation") increases tloc(a(MESH:Chemokines), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30967783 | bp(GO:"microglial cell activation") increases tloc(a(MESH:Cytokines), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30967783 | bp(GO:"microglial cell activation") increases a(MESH:Cytokines) |
| pubmed:26979166 | bp(GO:"microglial cell activation") increases tloc(a(MESH:Cytokines), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30967783 | bp(GO:"microglial cell activation") increases bp(GO:"excitatory postsynaptic potential") |
| pubmed:30967783 | bp(GO:"microglial cell activation") increases tloc(a(CHEBI:"2 L-glutamate"), fromLoc(MESH:Astrocytes), toLoc(MESH:Synapses)) |
| pubmed:30967783 | bp(GO:"microglial cell activation") increases a(MESH:"Reactive Oxygen Species") |
| pubmed:26979166 | bp(GO:"microglial cell activation") increases tloc(a(MESH:"Reactive Oxygen Species"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30967783 | bp(GO:"microglial cell activation") increases a(MESH:"Reactive Nitrogen Species") |
| pubmed:30967783 | bp(GO:"microglial cell activation") causesNoChange bp(GO:"T cell activation") |
| pubmed:30967783 | bp(GO:"microglial cell activation") increases bp(MESH:Remyelination) |
| pubmed:30967783 | bp(GO:"microglial cell activation") increases bp(GO:phagocytosis) |
| pubmed:30988501 | bp(GO:"microglial cell activation") increases bp(GO:phagocytosis) |
| pubmed:30988501 | bp(GO:"microglial cell activation") increases bp(GO:phagocytosis) |
| pubmed:30988501 | bp(GO:"microglial cell activation") increases bp(GO:phagocytosis) |
| pubmed:30967783 | bp(GO:"microglial cell activation") directlyIncreases g(HGNC:PRSS3P2) |
| pubmed:30967783 | bp(GO:"microglial cell activation") increases tloc(p(HGNC:IGF1), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30967783 | bp(GO:"microglial cell activation") increases tloc(p(MESH:"Fibroblast Growth Factors"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30967783 | bp(GO:"microglial cell activation") increases bp(GO:neurogenesis) |
| pubmed:30967783 | bp(GO:"microglial cell activation") increases p(HGNC:IL4) |
| pubmed:30967783 | bp(GO:"microglial cell activation") increases p(MESH:Activins) |
| pubmed:30967783 | bp(GO:"microglial cell activation") association a(DRUGBANK:"Ethyl pyruvate") |
| pubmed:30967783 | bp(GO:"microglial cell activation") association a(CHEBI:spermidine) |
| pubmed:30967783 | bp(GO:"microglial cell activation") association a(CHEBI:"bryostatin 1") |
| pubmed:30967783 | bp(GO:"microglial cell activation") association a(CHEBI:forskolin) |
| pubmed:30967783 | bp(GO:"microglial cell activation") association a(DRUGBANK:Lenalidomide) |
| pubmed:" 26517285" | bp(GO:"microglial cell activation") association bp(GO:"immune response") |
| pubmed:" 26517285" | bp(GO:"microglial cell activation") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:" 26517285" | bp(GO:"microglial cell activation") association g(DBSNP:rs3824968) |
| pubmed:20100581 | bp(GO:"microglial cell activation") association bp(GO:"apoptotic process") |
| pubmed:26836182 | bp(GO:"microglial cell activation") positiveCorrelation path(CONSO:neuroinflammation) |
| pubmed:26836182 | bp(GO:"microglial cell activation") increases p(HGNC:CHI3L1) |
| pubmed:26979166 | bp(GO:"microglial cell activation") increases p(HGNC:CHI3L1) |
| pubmed:21871088 | bp(GO:"microglial cell activation") association a(NIFT:"Hippocampal atrophy") |
| pubmed:21871088 | bp(GO:"microglial cell activation") association a(NIFT:"White matter lesion") |
| pubmed:26979166 | bp(GO:"microglial cell activation") decreases a(CHEBI:monoamine) |
| pubmed:26979166 | bp(GO:"microglial cell activation") association path(HP:Psychosis) |
| pubmed:26979166 | bp(GO:"microglial cell activation") increases tloc(a(CHEBI:prostaglandin), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:26979166 | bp(GO:"microglial cell activation") increases p(HGNC:IL1B) |
| pubmed:27314526 | bp(GO:"microglial cell activation") increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:26979166 | bp(GO:"microglial cell activation") increases p(HGNC:IL1R1) |
| pubmed:26979166 | bp(GO:"microglial cell activation") increases p(HGNC:MYD88) |
| pubmed:26979166 | bp(GO:"microglial cell activation") increases p(HGNC:NOS2) |
| pubmed:27314526 | bp(GO:"microglial cell activation") increases tloc(p(HGNC:NOS2), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:26979166 | bp(GO:"microglial cell activation") increases p(HGNC:CCL2) |
| pubmed:26979166 | bp(GO:"microglial cell activation") positiveCorrelation path(MESH:Depression) |
| pubmed:26979166 | bp(GO:"microglial cell activation") increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:21718217 | bp(GO:"microglial cell activation") association a(CONSO:CONSO00089) |
| pubmed:21718217 | bp(GO:"microglial cell activation") positiveCorrelation a(CONSO:CONSO00089) |
| pubmed:30106381 | bp(GO:"microglial cell activation") association p(HGNC:AIF1) |
| pubmed:26010758 | bp(GO:"microglial cell activation") positiveCorrelation p(HGNC:AIF1) |
| pubmed:27209302 | bp(GO:"microglial cell activation") increases deg(p(CONSO:"amyloid-beta oligomers")) |
| pubmed:27209302 | bp(GO:"microglial cell activation") increases deg(p(CONSO:"amyloid-beta oligomers")) |
| pubmed:27209302 | bp(GO:"microglial cell activation") increases deg(p(CONSO:"amyloid-beta fibrils")) |
| pubmed:27209302 | bp(GO:"microglial cell activation") increases deg(p(CONSO:"amyloid-beta aggregates")) |
| pubmed:27209302 | bp(GO:"microglial cell activation") increases deg(p(CONSO:"amyloid-beta aggregates")) |
| pubmed:27209302 | bp(GO:"microglial cell activation") decreases path(MESH:"Plaque, Amyloid") |
| pubmed:28877763 | bp(GO:"microglial cell activation") positiveCorrelation act(p(MGI:Syk)) |
| pubmed:28877763 | bp(GO:"microglial cell activation") positiveCorrelation p(MGI:Syk, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27314526 | bp(GO:"microglial cell activation") increases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30988501 | bp(GO:"microglial cell activation") increases a(MESH:"Inflammation Mediators") |
| pubmed:30988501 | bp(GO:"microglial cell activation") increases bp(GO:"cytokine production") |
| pubmed:30988501 | bp(GO:"microglial cell activation") increases act(p(INTERPRO:"Flavodoxin/nitric oxide synthase")) |
| pubmed:30988501 | bp(GO:"microglial cell activation") increases act(complex(GO:"NADPH oxidase complex")) |
| pubmed:30988501 | bp(GO:"microglial cell activation") increases deg(a(MESH:Neurons)) |
| pubmed:30988501 | bp(GO:"microglial cell activation") negativeCorrelation path(MESH:"Hereditary Diffuse Leukoencephalopathy with Spheroids") |
| pubmed:30988501 | bp(GO:"microglial cell activation") increases a(MESH:"Neural Pathways") |
| pubmed:30988501 | bp(GO:"microglial cell activation") increases bp(GO:"neuroinflammatory response") |
| pubmed:29179999 | a(PUBCHEM:444795) decreases path(MESH:Inflammation) |
| pubmed:29179999 | a(PUBCHEM:444795) decreases p(HGNC:IL6) |
| pubmed:29179999 | a(PUBCHEM:444795) decreases p(HGNC:IL12B) |
| pubmed:29179999 | a(PUBCHEM:444795) decreases p(HGNC:TNF) |
| pubmed:29179999 | a(PUBCHEM:444795) decreases act(p(FPLX:NFkappaB)) |
| pubmed:29179999 | a(PUBCHEM:444795) decreases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pubmed:29179999 | a(PUBCHEM:444795) decreases p(HGNC:BACE1) |
| pubmed:29179999 | a(PUBCHEM:444795) decreases complex(g(HGNC:BACE1), p(FPLX:NFkappaB)) |
| pubmed:29179999 | a(PUBCHEM:3086007) decreases a(CHEBI:amyloid-beta) |
| pubmed:29179999 | a(PUBCHEM:441921) decreases a(CHEBI:amyloid-beta) |
| pubmed:29179999 | a(PUBCHEM:9918693) decreases a(CHEBI:amyloid-beta) |
| pubmed:29179999 | a(PUBCHEM:441923) decreases a(CHEBI:amyloid-beta) |
| pubmed:29179999 | a(PUBCHEM:441923) decreases r(HGNC:TLR3) |
| pubmed:29179999 | a(PUBCHEM:441923) decreases p(HGNC:TLR3) |
| pubmed:29179999 | a(PUBCHEM:441923) decreases r(HGNC:TLR4) |
| pubmed:29179999 | a(PUBCHEM:441923) decreases p(HGNC:TLR4) |
| pubmed:29179999 | a(PUBCHEM:441923) decreases r(FPLX:NFkappaB) |
| pubmed:29179999 | a(PUBCHEM:441923) decreases p(FPLX:NFkappaB) |
| pubmed:29179999 | a(PUBCHEM:441923) decreases r(HGNC:TRAF6) |
| pubmed:29179999 | a(PUBCHEM:441923) decreases p(HGNC:TRAF6) |
| pubmed:29179999 | a(PUBCHEM:441923) decreases r(HGNC:TNF) |
| pubmed:29179999 | a(PUBCHEM:441923) decreases r(HGNC:IFNB1) |
| pubmed:29179999 | a(PUBCHEM:24721561) decreases bp(GO:"neuron death") |
| pubmed:29179999 | a(PUBCHEM:24721561) increases bp(GO:learning) |
| pubmed:29179999 | a(PUBCHEM:24721561) increases bp(GO:memory) |
| pubmed:29179999 | a(PUBCHEM:24721561) decreases act(p(FPLX:NFkappaB)) |
| pubmed:26979166 | act(p(HGNC:TLR3)) increases r(MESH:Cytokines) |
| pubmed:26551702 | act(p(HGNC:TRAF6)) increases act(p(HGNC:NGF)) |
| pubmed:30962309 | p(HGNC:TRAF6) increases p(HGNCGENEFAMILY:"IKK complex") |
| pubmed:30962309 | p(HGNC:TRAF6) increases r(HGNC:NLRP3) |
| pubmed:30962309 | p(HGNC:TRAF6) increases r(HGNC:PYCARD) |
| pubmed:30962309 | p(HGNC:TRAF6) increases r(HGNC:CASP1) |
| pubmed:30962309 | p(HGNC:TRAF6) increases p(HGNC:NLRP3) |
| pubmed:30962309 | p(HGNC:TRAF6) increases p(HGNC:PYCARD) |
| pubmed:30962309 | p(HGNC:TRAF6) increases p(HGNC:CASP1) |
| pubmed:29661268 | p(HGNC:TRAF6) increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:22110360 | p(HGNC:TRAF6) increases act(p(HGNC:MAP3K5)) |
| pubmed:26631930 | p(HGNC:TRAF6) increases p(HGNC:MAPT, pmod(go:0070534 ! "protein K63-linked ubiquitination")) |
| pubmed:29179999 | a(PUBCHEM:164676) decreases act(p(HGNC:NOS2)) |
| pubmed:29179999 | a(PUBCHEM:164676) decreases act(p(HGNC:MMP2)) |
| pubmed:29179999 | a(PUBCHEM:164676) decreases act(p(HGNC:RELA)) |
| pubmed:29179999 | a(PUBCHEM:164676) decreases path(MESH:"Alzheimer Disease") |
| pubmed:29179999 | a(PUBCHEM:164676) decreases bp(GO:"apoptotic process") |
| pubmed:29179999 | a(PUBCHEM:164676) decreases path(MESH:Inflammation) |
| pubmed:29179999 | a(PUBCHEM:164676) decreases bp(GO:"neuron death") |
| pubmed:29179999 | a(PUBCHEM:164676) decreases p(HGNC:GFAP) |
| pubmed:29179999 | a(PUBCHEM:164676) decreases p(FPLX:NFkappaB) |
| pubmed:29179999 | a(PUBCHEM:164676) increases r(HGNC:RBFOX3) |
| pubmed:29179999 | a(PUBCHEM:164676) increases a(MESH:"Nissl Bodies") |
| pubmed:29179999 | a(PUBCHEM:164676) increases r(FPLX:IKB) |
| pubmed:27594586 | act(p(HGNC:MMP2)) increases bp(GO:"neuron death") |
| pubmed:27594586 | p(HGNC:MMP2) increases bp(GO:"neuron death") |
| pubmed:26195256 | p(HGNC:MMP2) increases deg(a(CHEBI:amyloid-beta, loc(GO:"extracellular region"))) |
| pubmed:29626319 | act(p(HGNC:MMP2)) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:26195256 | p(HGNC:MMP2) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26195256 | act(p(HGNC:MMP2)) negativeCorrelation path(MESH:"Plaque, Amyloid") |
| pubmed:25652642 | p(HGNC:GFAP) positiveCorrelation m(HGNC:MIR125B1) |
| pubmed:29179999 | a(CHEBI:"(+)-artemisinin") decreases path(MESH:Inflammation) |
| pubmed:29179999 | a(CHEBI:"(+)-artemisinin") decreases act(p(FPLX:NFkappaB)) |
| pubmed:29179999 | a(CHEBI:"(+)-artemisinin") decreases a(CHEBI:amyloid-beta) |
| pubmed:29179999 | a(CHEBI:"(+)-artemisinin") decreases bp(GO:"NLRP3 inflammasome complex assembly") |
| pubmed:28019679 | a(CHEBI:"(+)-artemisinin") decreases p(MGI:Nfkbia) |
| pubmed:28019679 | a(CHEBI:"(+)-artemisinin") decreases complex(GO:"NLRP3 inflammasome complex") |
| pubmed:29179999 | a(PUBCHEM:440312) decreases a(CHEBI:"nitric oxide") |
| pubmed:29179999 | a(PUBCHEM:440312) decreases p(HGNC:TNF) |
| pubmed:29179999 | a(PUBCHEM:440312) decreases a(CHEBI:"prostaglandin E2") |
| pubmed:29179999 | a(PUBCHEM:440312) decreases p(HGNC:NOS2) |
| pubmed:29179999 | a(PUBCHEM:440312) decreases p(HGNC:PTGS2) |
| pubmed:29179999 | a(PUBCHEM:440312) decreases act(p(HGNC:LOX)) |
| pubmed:29179999 | a(PUBCHEM:440312) decreases a(CHEBI:"reactive oxygen species") |
| pubmed:29179999 | a(PUBCHEM:440312) decreases act(p(FPLX:ERK)) |
| pubmed:29179999 | a(PUBCHEM:440312) decreases act(p(HGNC:MAPK14)) |
| pubmed:29179999 | a(PUBCHEM:440312) decreases act(p(FPLX:NFkappaB)) |
| pubmed:29179999 | a(CHEBI:Geniposide) decreases act(p(FPLX:ERK)) |
| pubmed:29179999 | a(CHEBI:Geniposide) decreases act(p(FPLX:IKB)) |
| pubmed:29179999 | a(CHEBI:Geniposide) decreases act(p(FPLX:NFkappaB)) |
| pubmed:29179999 | a(CHEBI:Geniposide) decreases r(HGNC:TNF) |
| pubmed:29179999 | a(CHEBI:Geniposide) decreases r(HGNC:IL1B) |
| pubmed:29179999 | a(CHEBI:Geniposide) decreases a(CHEBI:amyloid-beta) |
| pubmed:27288790 | deg(p(FPLX:IKB)) increases act(complex(p(FPLX:NFkappaB), p(FPLX:NFkappaB))) |
| pubmed:27288790 | r(HGNC:IL1B) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pubmed:29179999 | a(PUBCHEM:102336202) increases path(MESH:"Spatial Memory") |
| pubmed:29179999 | a(PUBCHEM:102336202) decreases path(MESH:"Oxidative Stress") |
| pubmed:29179999 | a(PUBCHEM:102336202) decreases p(HGNC:NOS2) |
| pubmed:29179999 | a(PUBCHEM:102336202) decreases a(CHEBI:nitrotyrosine) |
| pubmed:29179999 | a(PUBCHEM:102336202) increases r(HGNC:IL4) |
| pubmed:29179999 | a(PUBCHEM:102336202) decreases a(MESH:Cytokines) |
| pubmed:29179999 | a(PUBCHEM:102336202) decreases a(CHEBI:"nitric oxide") |
| pubmed:29179999 | a(PUBCHEM:102336202) decreases p(HGNC:IL1B) |
| pubmed:29179999 | a(PUBCHEM:102336202) decreases p(HGNC:TNF) |
| pubmed:29179999 | a(PUBCHEM:102336202) decreases act(p(FPLX:ERK)) |
| pubmed:29179999 | a(PUBCHEM:102336202) decreases act(p(FPLX:NFkappaB)) |
| pubmed:29179999 | a(CHEBI:"N(5)-ethyl-L-glutamine") increases bp(GO:memory) |
| pubmed:29179999 | a(CHEBI:"N(5)-ethyl-L-glutamine") decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:29179999 | a(CHEBI:"N(5)-ethyl-L-glutamine") decreases bp(GO:"neuron death") |
| pubmed:29179999 | a(CHEBI:"N(5)-ethyl-L-glutamine") decreases act(p(FPLX:ERK)) |
| pubmed:29179999 | a(CHEBI:"N(5)-ethyl-L-glutamine") decreases act(p(HGNC:MAPK14)) |
| pubmed:29179999 | a(CHEBI:"N(5)-ethyl-L-glutamine") decreases act(p(FPLX:NFkappaB)) |
| pubmed:29179999 | a(CHEBI:"1,8-cineole") decreases a(CHEBI:"reactive oxygen species") |
| pubmed:29179999 | a(CHEBI:"1,8-cineole") decreases a(CHEBI:"nitric oxide") |
| pubmed:29179999 | a(CHEBI:"1,8-cineole") decreases r(HGNC:TNF) |
| pubmed:29179999 | a(CHEBI:"1,8-cineole") decreases r(HGNC:IL1B) |
| pubmed:29179999 | a(CHEBI:"1,8-cineole") decreases r(HGNC:IL6) |
| pubmed:29179999 | a(CHEBI:"1,8-cineole") decreases r(HGNC:NOS2) |
| pubmed:29179999 | a(CHEBI:"1,8-cineole") decreases r(HGNC:PTGS2) |
| pubmed:29179999 | a(CHEBI:"1,8-cineole") decreases r(FPLX:NFkappaB) |
| pubmed:27288790 | r(HGNC:NOS2) increases path(MESH:Inflammation) |
| pubmed:29179999 | a(PUBCHEM:442534) increases bp(GO:memory) |
| pubmed:29179999 | a(PUBCHEM:442534) decreases a(CONSO:"amyloid-beta aggregates") |
| pubmed:29179999 | a(PUBCHEM:442534) decreases path(MESH:"Alzheimer Disease") |
| pubmed:29179999 | a(PUBCHEM:442534) decreases act(p(FPLX:GSK3)) |
| pubmed:29179999 | a(PUBCHEM:442534) decreases act(p(FPLX:NFkappaB)) |
| pubmed:29179999 | a(PUBCHEM:442534) decreases bp(GO:"NLRP3 inflammasome complex assembly") |
| pubmed:29179999 | a(PUBCHEM:442534) decreases p(HGNC:TNF) |
| pubmed:29179999 | a(PUBCHEM:442534) decreases p(HGNC:IL1B) |
| pubmed:8282104 | p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:8282104 | p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:8282104 | p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:8282104 | p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 235)) |
| pubmed:8282104 | p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:8282104 | p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:8282104 | p(FPLX:GSK3) association a(GO:microtubule) |
| pubmed:8282104 | p(FPLX:GSK3) association a(CONSO:CONSO00006) |
| pubmed:8282104 | p(FPLX:GSK3) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")))) |
| pubmed:8282104 | p(FPLX:GSK3) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27288790 | bp(GO:"negative regulation of neuron apoptotic process") association p(FPLX:NFkappaB) |
| pubmed:12428809 | bp(GO:"negative regulation of neuron apoptotic process") association tloc(p(HGNC:APP), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27288790 | bp(GO:"neuron differentiation") association p(FPLX:NFkappaB) |
| pubmed:22110360 | bp(GO:"neuron differentiation") association p(FPLX:CREB, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24590577 | bp(GO:"neuron differentiation") association p(HGNC:CHRM1) |
| pubmed:18986241 | bp(GO:"neuron differentiation") association bp(GO:"MAPK cascade") |
| pubmed:27807169 | bp(GO:"neuron differentiation") positiveCorrelation act(p(RGD:Cdk5)) |
| pubmed:28884684 | bp(GO:"neuron differentiation") positiveCorrelation act(p(HGNC:DYRK1A), ma(go:0016301 ! "kinase activity")) |
| pubmed:27288790 | bp(GO:"regulation of synaptic plasticity") association p(FPLX:NFkappaB) |
| pubmed:27288790 | bp(GO:"regulation of synaptic plasticity") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:30444369 | bp(GO:"regulation of synaptic plasticity") association p(HGNC:SH3GL2) |
| pubmed:11880483 | bp(GO:"regulation of synaptic plasticity") association p(FPLX:p38, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:11880483 | bp(GO:"regulation of synaptic plasticity") association p(HGNCGENEFAMILY:"Mitogen-activated protein kinases", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27041503 | bp(GO:"regulation of synaptic plasticity") increases a(NIFT:"Hippocampal atrophy") |
| pubmed:25800888 | bp(GO:"regulation of synaptic plasticity") association p(HGNC:WWC1) |
| pubmed:21543606 | bp(GO:"regulation of synaptic plasticity") association bp(GO:"axonal defasciculation") |
| pubmed:21543606 | bp(GO:"regulation of synaptic plasticity") association bp(GO:myelination) |
| pubmed:17009926 | bp(GO:"regulation of synaptic plasticity") association p(FPLX:CHRN) |
| pubmed:17009926 | bp(GO:"regulation of synaptic plasticity") association p(FPLX:CHRN) |
| pubmed:24590577 | bp(GO:"regulation of synaptic plasticity") association p(HGNC:CHRM1) |
| pubmed:30106381 | bp(GO:"regulation of synaptic plasticity") association p(HGNC:DLG4) |
| pubmed:22908190 | bp(GO:"regulation of synaptic plasticity") association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:22908190 | bp(GO:"regulation of synaptic plasticity") association bp(GO:endocytosis) |
| pubmed:22908190 | bp(GO:"regulation of synaptic plasticity") association bp(GO:autophagy) |
| pubmed:26631930 | bp(GO:"regulation of synaptic plasticity") association p(HGNC:MAPT) |
| pubmed:27288790 | p(FPLX:IKB, pmod(go:0006468 ! "protein phosphorylation")) increases deg(p(FPLX:IKB)) |
| pubmed:27288790 | p(FPLX:IKB, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(FPLX:NFkappaB)) |
| pubmed:27288790 | act(complex(p(FPLX:NFkappaB), p(FPLX:NFkappaB))) increases tloc(complex(p(FPLX:NFkappaB), p(FPLX:NFkappaB)), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pubmed:27288790 | act(complex(p(FPLX:NFkappaB), p(FPLX:NFkappaB))) increases act(complex(p(FPLX:NFkappaB), p(FPLX:NFkappaB)), ma(GO:"DNA binding")) |
| pubmed:27288790 | p(FPLX:NFkappaB, pmod(go:0006468 ! "protein phosphorylation", Ser, 536)) increases act(p(HGNC:RELA)) |
| pubmed:26010758 | p(FPLX:NFkappaB, pmod(go:0006468 ! "protein phosphorylation", Ser, 536)) association path(MESH:"Plaque, Amyloid") |
| pubmed:27288790 | bp(MESH:"Membrane Fluidity") association a(CHEBI:"reactive oxygen species") |
| pubmed:27288790 | bp(GO:"ion transport") association a(CHEBI:"reactive oxygen species") |
| pubmed:25031639 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) |
| pubmed:30985105 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases act(p(HGNC:MAPT)) |
| pubmed:26195256 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation), loc(MESH:"Cerebrospinal Fluid")) positiveCorrelation p(HGNC:MAPT, loc(MESH:"Neurofibrillary Tangles")) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) |
| pubmed:25031639 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases p(CONSO:"Tau aggregates", loc(GO:cytosol)) |
| pubmed:29844403 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases p(CONSO:"Tau aggregates") |
| pubmed:25031639 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases p(MESH:"Neurofibrillary Tangles") |
| pubmed:29844403 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases p(MESH:"Neurofibrillary Tangles") |
| pubmed:25031639 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases p(CONSO:"paired helical filaments") |
| pubmed:25031639 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) negativeCorrelation bp(GO:"axonal transport") |
| pubmed:29844403 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) negativeCorrelation bp(GO:"axonal transport") |
| pubmed:22611162 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases bp(GO:"axonal transport") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases bp(GO:"axonal transport") |
| pubmed:25031639 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) negativeCorrelation bp(GO:"synaptic signaling") |
| pubmed:22611162 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases bp(GO:"synaptic signaling") |
| pubmed:25031639 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) negativeCorrelation act(complex(GO:microtubule), ma(GO:"microtubule motor activity")) |
| pubmed:29844403 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases p(CONSO:"Tau oligomers") |
| pubmed:29844403 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases path(DOID:neuropathy) |
| pubmed:29844403 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) negativeCorrelation bp(GO:"cellular respiration") |
| pubmed:30061532 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) association path(MESH:"Lewy Body Disease") |
| pubmed:30061532 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases path(MESH:"Alzheimer Disease") |
| pubmed:30145931 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:17403556 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25374103 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24401760 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:30061532 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pubmed:30061532 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation path(MESH:Schizophrenia) |
| pubmed:30061532 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation p(HGNC:CDK5) |
| pubmed:17009926 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation p(HGNC:CHRNA7) |
| pubmed:17009926 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation p(HGNC:CHRNA4) |
| pubmed:18986241 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) association a(MESH:"Neurofibrillary Tangles") |
| pubmed:26195256 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) association a(MESH:"Neurofibrillary Tangles") |
| pubmed:11230871 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) negativeCorrelation p(FPLX:CHRN) |
| pubmed:19277525 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases a(GO:"neurofibrillary tangle") |
| pubmed:22908190 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) association a(GO:"neurofibrillary tangle") |
| pubmed:22299660 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases bp(GO:"microtubule polymerization") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases bp(GO:"microtubule polymerization") |
| pubmed:22299660 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) negativeCorrelation act(p(FPLX:PPP2)) |
| pubmed:21722302 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases bp(GO:"cytoskeleton organization") |
| pubmed:29758300 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:30985105 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:29758300 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases a(CONSO:"Tau aggregates") |
| pubmed:21882945 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases a(CONSO:"Tau aggregates") |
| pubmed:26458742 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases a(CONSO:"Tau aggregates") |
| pubmed:29758300 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases bp(GO:"microtubule depolymerization") |
| pubmed:30145931 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation path(MESH:Tauopathies) |
| pubmed:22611162 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases bp(GO:"maintenance of synapse structure") |
| pubmed:21734277 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) association p(CONSO:"Tau epitope, AT8", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30985105 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases a(CONSO:"Tau oligomers") |
| pubmed:26195256 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) association a(MESH:"Neuropil Threads") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases complex(GO:"filamentous actin") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases path(CONSO:Neurodegeneration) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases act(a(GO:synapse)) |
| pubmed:14963027 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) association p(HGNC:HSPB1) |
| pubmed:14963027 | act(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) increases bp(GO:"neuron apoptotic process") |
| pubmed:17954934 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) negativeCorrelation p(HGNC:BAG1) |
| pubmed:23487739 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases a(GO:microtubule) |
| pubmed:19732809 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) negativeCorrelation p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:25378699 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation p(HGNC:MAPT, pmod(go:0016925 ! "protein sumoylation", Lys, 340)) |
| pubmed:19623258 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) association a(CHEBI:"quinolinic acid") |
| pubmed:27288790 | a(CHEBI:"hydrogen peroxide") increases act(p(FPLX:NFkappaB)) |
| pubmed:27288790 | a(CHEBI:"hydrogen peroxide") increases act(p(FPLX:ERK)) |
| pubmed:27288790 | a(CHEBI:"hydrogen peroxide") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21861815 | a(CHEBI:"hydrogen peroxide") decreases p(HGNC:HIF1A) |
| pubmed:14556719 | a(CHEBI:"hydrogen peroxide") increases bp(GO:"response to unfolded protein") |
| pubmed:23531502 | act(a(CHEBI:"hydrogen peroxide")) increases a(CONSO:"Tau aggregates") |
| pubmed:23722080 | a(CHEBI:"hydrogen peroxide") increases bp(MESH:"Oxidative Stress") |
| pubmed:23722080 | a(CHEBI:"hydrogen peroxide") positiveCorrelation composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) |
| pubmed:27288790 | p(HGNC:IL18) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24561250 | p(HGNC:IL18) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27314526 | p(HGNC:IL18) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27314526 | p(HGNC:IL18) association path(MESH:"Alzheimer Disease") |
| pubmed:27288790 | p(HGNC:IL18) increases act(p(FPLX:NFkappaB)) |
| pubmed:30962309 | p(HGNC:IL18) association path(DOID:cancer) |
| pubmed:30962309 | p(HGNC:IL18) association path(DOID:"multiple sclerosis") |
| pubmed:30962309 | p(HGNC:IL18) association path(DOID:"rheumatic disease") |
| pubmed:30967783 | p(HGNC:IL18) increases bp(GO:"inflammatory response") |
| pubmed:24561250 | p(HGNC:IL18) increases bp(GO:"inflammatory response") |
| pubmed:30967783 | p(HGNC:IL18) increases path(EFO:"experimental autoimmune encephalomyelitis") |
| pubmed:23092889 | p(HGNC:IL18) increases bp(GO:pyroptosis) |
| pubmed:24561250 | p(HGNC:IL18) positiveCorrelation complex(GO:"inflammasome complex") |
| pubmed:27314526 | p(HGNC:IL18) positiveCorrelation path(MESH:Dementia) |
| pubmed:27314526 | p(HGNC:IL18) increases bp(GO:"microglial cell activation") |
| pubmed:27314526 | p(HGNC:IL18) increases bp(GO:"astrocyte activation") |
| pubmed:27314526 | p(HGNC:IL18) increases a(CHEBI:amyloid-beta) |
| pubmed:27314526 | p(HGNC:IL18) increases p(HGNC:GSK3B) |
| pubmed:27314526 | p(HGNC:IL18) increases p(HGNC:CDK5) |
| pubmed:27288790 | p(HGNC:CXCL10) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27288790 | p(HGNC:TGFB1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26304819 | p(HGNC:TGFB1) biomarkerFor path(MESH:"Alzheimer Disease") |
| pubmed:30967783 | p(HGNC:TGFB1) decreases bp(GO:"inflammatory response") |
| pubmed:21718217 | p(HGNC:TGFB1) decreases a(MESH:Macrophages) |
| pubmed:27288790 | bp(GO:"protein kinase B signaling") increases act(p(FPLX:NFkappaB)) |
| pubmed:30061532 | bp(GO:"protein kinase B signaling") association path(MESH:Schizophrenia) |
| pubmed:30061532 | bp(GO:"protein kinase B signaling") association path(MESH:Schizophrenia) |
| pubmed:30061532 | bp(GO:"protein kinase B signaling") association p(HGNC:NRG1) |
| pubmed:18986241 | bp(GO:"protein kinase B signaling") regulates bp(MESH:"Cell Survival") |
| pubmed:18986241 | bp(GO:"protein kinase B signaling") association p(FPLX:RAS) |
| pubmed:18986241 | bp(GO:"protein kinase B signaling") association p(HGNC:IRS1) |
| pubmed:18986241 | bp(GO:"protein kinase B signaling") association p(HGNC:GAB1) |
| pubmed:14556719 | bp(GO:"neuron apoptotic process") positiveCorrelation p(HGNC:CCNE1) |
| pubmed:29311797 | bp(GO:"neuron apoptotic process") decreases bp(GO:cognition) |
| pubmed:14963027 | bp(GO:"neuron apoptotic process") negativeCorrelation p(HGNC:HSPB1) |
| pubmed:27068745 | bp(GO:"neuron apoptotic process") positiveCorrelation p(HGNC:UNC5C) |
| pubmed:27288790 | bp(GO:"MAPK cascade") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27288790 | bp(GO:"MAPK cascade") increases p(FPLX:IKB, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21214928 | bp(GO:"MAPK cascade") association a(CHEBI:amyloid-beta) |
| pubmed:19293145 | bp(GO:"MAPK cascade") increases a(CHEBI:amyloid-beta) |
| pubmed:19126755 | bp(GO:"MAPK cascade") increases act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:19126755 | bp(GO:"MAPK cascade") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19293145 | bp(GO:"MAPK cascade") increases act(p(HGNC:BAD)) |
| pubmed:19293145 | bp(GO:"MAPK cascade") increases act(p(HGNC:MYC)) |
| pubmed:19293145 | bp(GO:"MAPK cascade") increases act(p(HGNC:MYC)) |
| pubmed:19293145 | bp(GO:"MAPK cascade") increases act(p(FPLX:NFkappaB)) |
| pubmed:19293145 | bp(GO:"MAPK cascade") increases act(p(HGNC:NOS1)) |
| pubmed:24590577 | bp(GO:"MAPK cascade") increases p(HGNC:BACE1) |
| pubmed:18986241 | bp(GO:"MAPK cascade") association bp(GO:"apoptotic process") |
| pubmed:18986241 | bp(GO:"MAPK cascade") association bp(GO:"neuron differentiation") |
| pubmed:18986241 | bp(GO:"MAPK cascade") increases act(p(FPLX:RAS)) |
| pubmed:18986241 | bp(GO:"MAPK cascade") increases act(p(FPLX:RAF)) |
| pubmed:18986241 | bp(GO:"MAPK cascade") increases act(p(FPLX:MEK)) |
| pubmed:18986241 | bp(GO:"MAPK cascade") increases act(p(FPLX:P90RSK)) |
| pubmed:18986241 | bp(GO:"MAPK cascade") increases act(p(HGNC:MAPKAPK2)) |
| pubmed:23393546 | bp(GO:"MAPK cascade") negativeCorrelation path(DOID:"Huntington's disease") |
| pubmed:23393546 | bp(GO:"MAPK cascade") negativeCorrelation path(DOID:"Huntington's disease") |
| pubmed:27288790 | bp(GO:"ERK1 and ERK2 cascade") increases act(p(FPLX:NFkappaB)) |
| pubmed:21214928 | bp(GO:"ERK1 and ERK2 cascade") association a(CHEBI:amyloid-beta) |
| pubmed:19126755 | bp(GO:"ERK1 and ERK2 cascade") increases act(a(CHEBI:nicotine)) |
| pubmed:19293145 | bp(GO:"ERK1 and ERK2 cascade") decreases bp(GO:"apoptotic process") |
| pubmed:24590577 | bp(GO:"ERK1 and ERK2 cascade") regulates act(p(HGNC:ADAM10)) |
| pubmed:24590577 | bp(GO:"ERK1 and ERK2 cascade") regulates bp(CONSO:"APP processing") |
| pubmed:23393546 | bp(GO:"ERK1 and ERK2 cascade") increases bp(MESH:"Cell Survival") |
| pubmed:23393546 | bp(GO:"ERK1 and ERK2 cascade") positiveCorrelation p(HGNC:NF2) |
| pubmed:27594586 | bp(GO:"ERK1 and ERK2 cascade") regulates p(HGNC:MMP9) |
| pubmed:27288790 | a(CHEBI:SB-239063) decreases act(p(HGNC:MAPK14)) |
| pubmed:27288790 | a(CHEBI:SB-239063) decreases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27288790 | a(CHEBI:SB-239063) decreases tloc(p(HGNC:RELA), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pubmed:27288790 | a(CHEBI:"anthra[1,9-cd]pyrazol-6(2H)-one") decreases p(FPLX:JNK) |
| pubmed:27288790 | a(CHEBI:"anthra[1,9-cd]pyrazol-6(2H)-one") increases act(p(HGNC:MAPK14)) |
| pubmed:27288790 | a(CHEBI:"anthra[1,9-cd]pyrazol-6(2H)-one") increases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27288790 | a(CHEBI:"advanced glycation end-product") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:24183963 | a(CHEBI:"advanced glycation end-product") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:27288790 | a(CHEBI:"advanced glycation end-product") decreases bp(GO:memory) |
| pubmed:27288790 | a(CHEBI:"advanced glycation end-product") increases bp(GO:"cellular protein catabolic process") |
| pubmed:27288790 | a(CHEBI:"advanced glycation end-product") decreases bp(GO:"long-term synaptic potentiation") |
| pubmed:24183963 | a(CHEBI:"advanced glycation end-product") directlyIncreases act(p(HGNC:AGER)) |
| pubmed:8063802 | a(CHEBI:"advanced glycation end-product") increases act(p(HGNC:AGER)) |
| pubmed:26095350 | a(CHEBI:"advanced glycation end-product") increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) |
| pubmed:26095350 | a(CHEBI:"advanced glycation end-product") increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:26095350 | a(CHEBI:"advanced glycation end-product") increases p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) |
| pubmed:8063802 | a(CHEBI:"advanced glycation end-product") decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:8063802 | a(CHEBI:"advanced glycation end-product") increases a(CONSO:"Tau aggregates") |
| pubmed:18930136 | bp(GO:"cellular protein catabolic process") regulates bp(GO:"cellular homeostasis") |
| pubmed:18930136 | bp(GO:"cellular protein catabolic process") negativeCorrelation path(MESH:Neoplasms) |
| pubmed:18930136 | bp(GO:"cellular protein catabolic process") negativeCorrelation path(CONSO:Neurodegeneration) |
| pubmed:25036637 | bp(GO:"cellular protein catabolic process") association p(HGNC:DCP1A) |
| pubmed:25036637 | bp(GO:"cellular protein catabolic process") association p(HGNC:EDC3) |
| pubmed:25036637 | bp(GO:"cellular protein catabolic process") association p(HGNC:DDX6) |
| pubmed:27288790 | a(CHEBI:pentosidine) isA a(CHEBI:"advanced glycation end-product") |
| pubmed:27288790 | a(CHEBI:pentosidine) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27288790 | a(CONSO:GLAP) isA a(CHEBI:"advanced glycation end-product") |
| pubmed:27288790 | a(CONSO:GLAP) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27288790 | complex(a(CHEBI:pentosidine), p(HGNC:AGER)) increases p(HGNC:BACE1) |
| pubmed:27288790 | complex(a(CHEBI:pentosidine), p(HGNC:AGER)) increases act(p(FPLX:NFkappaB)) |
| pubmed:27288790 | complex(a(CONSO:GLAP), p(HGNC:AGER)) increases p(HGNC:BACE1) |
| pubmed:27288790 | complex(a(CONSO:GLAP), p(HGNC:AGER)) increases act(p(FPLX:NFkappaB)) |
| pubmed:27288790 | p(HGNC:GSK3B) increases r(HGNC:BACE1) |
| pubmed:26551702 | p(HGNC:GSK3B) increases deg(p(HGNC:NFE2L2)) |
| pubmed:29121589 | act(p(HGNC:GSK3B)) negativeCorrelation p(HGNC:NFE2L2) |
| pubmed:24355211 | p(HGNC:GSK3B) decreases p(HGNC:NFE2L2) |
| pubmed:26551702 | p(HGNC:GSK3B) increases p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29121589 | p(HGNC:GSK3B) increases p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26551702 | p(HGNC:GSK3B) increases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22372633 | p(HGNC:GSK3B) increases act(p(HGNC:HDAC6), ma(GO:"deacetylase activity")) |
| pubmed:29844403 | act(p(HGNC:GSK3B)) association p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:29844403 | act(p(HGNC:GSK3B)) association p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Tyr, 216)) |
| pubmed:25546293 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 33)) |
| pubmed:25546293 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 33)) |
| pubmed:25546293 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 37)) |
| pubmed:25546293 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 37)) |
| pubmed:25546293 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 41)) |
| pubmed:25546293 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 41)) |
| pubmed:30935091 | p(HGNC:GSK3B) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30935091 | p(HGNC:GSK3B) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation", Ser, 33)) |
| pubmed:30935091 | p(HGNC:GSK3B) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation", Ser, 37)) |
| pubmed:30935091 | p(HGNC:GSK3B) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation", Thr, 41)) |
| pubmed:29661268 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30444369 | act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21156028 | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22530628 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:12428809 | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29758300 | p(HGNC:GSK3B) regulates p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21882945 | act(p(HGNC:GSK3B)) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29191965 | p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29311797 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:12551948 | act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:10998059 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27314526 | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29661268 | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:30697142 | act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:12428809 | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:18494933 | act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:24183963 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:18494933 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:29661268 | p(HGNC:GSK3B) increases path(DOID:"neurodegenerative disease") |
| pubmed:22122372 | p(HGNC:GSK3B) increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 654)) |
| pubmed:22122372 | p(HGNC:GSK3B) increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) |
| pubmed:22122372 | p(HGNC:GSK3B) increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Ser, 665)) |
| pubmed:30515821 | p(HGNC:GSK3B) increases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 40), pmod(go:0006468 ! "protein phosphorylation", Ser, 44)) |
| pubmed:30515821 | p(HGNC:GSK3B) increases act(p(HGNC:DNM1L), ma(GO:"GTPase activity")) |
| pubmed:30515821 | p(HGNC:GSK3B) regulates bp(GO:"mitochondrial fission") |
| pubmed:30515821 | p(HGNC:GSK3B) increases act(p(HGNC:CASP3)) |
| pubmed:30515821 | p(HGNC:GSK3B) increases a(CHEBI:amyloid-beta) |
| pubmed:30697142 | act(p(HGNC:GSK3B)) increases a(CHEBI:amyloid-beta) |
| pubmed:30515821 | p(HGNC:GSK3B) increases path(EFO:"memory impairment") |
| pubmed:30515821 | p(HGNC:GSK3B) increases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) |
| pubmed:22530628 | act(p(HGNC:GSK3B)) causesNoChange a(CONSO:"amyloid-beta aggregates") |
| pubmed:22530628 | act(p(HGNC:GSK3B)) decreases bp(GO:"neuron death") |
| pubmed:22530628 | act(p(HGNC:GSK3B)) increases bp(MESH:"Neuronal Plasticity") |
| pubmed:22530628 | act(p(HGNC:GSK3B)) increases bp(MESH:"Long-Term Potentiation") |
| pubmed:26979166 | act(p(HGNC:GSK3B)) decreases bp(MESH:"Long-Term Potentiation") |
| pubmed:30697142 | p(HGNC:GSK3B) increases bp(GO:"programmed cell death") |
| pubmed:30697142 | act(p(HGNC:GSK3B)) negativeCorrelation bp(GO:"learning or memory") |
| doi:"10.4172/2168-975X.1000126" | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:25331948 | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:14612456 | p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:17078951 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:19459590 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:29844403 | act(p(HGNC:GSK3B)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| doi:"10.4172/2168-975X.1000126" | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:25331948 | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:14612456 | p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:17078951 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:19459590 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| doi:"10.4172/2168-975X.1000126" | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:17078951 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| doi:"10.4172/2168-975X.1000126" | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:25331948 | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:14612456 | p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:17078951 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:19459590 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:24653673 | p(HGNC:GSK3B) association path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | act(p(HGNC:GSK3B)) negativeCorrelation a(GO:"microtubule cytoskeleton") |
| pubmed:24653673 | act(p(HGNC:GSK3B)) negativeCorrelation a(GO:"neurofilament cytoskeleton") |
| pubmed:24653673 | act(p(HGNC:GSK3B)) negativeCorrelation p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | act(p(HGNC:GSK3B)) negativeCorrelation bp(CONSO:"APP processing") |
| pubmed:24653673 | act(p(HGNC:GSK3B)) negativeCorrelation bp(GO:neurogenesis) |
| pubmed:24653673 | act(p(HGNC:GSK3B)) positiveCorrelation bp(GO:"negative regulation of synaptic plasticity") |
| pubmed:24653673 | act(p(HGNC:GSK3B)) positiveCorrelation bp(GO:"apoptotic process") |
| pubmed:24653673 | act(p(HGNC:GSK3B)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | act(p(HGNC:GSK3B)) increases p(FPLX:PPP2, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) |
| pubmed:24653673 | act(p(HGNC:GSK3B)) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) |
| pubmed:24653673 | act(p(HGNC:GSK3B)) decreases p(HGNC:PPP2CB, pmod(go:0006479 ! "protein methylation", Leu, 309)) |
| pubmed:24653673 | act(p(HGNC:GSK3B)) decreases act(p(HGNC:LCMT1)) |
| pubmed:24653673 | act(p(HGNC:GSK3B)) increases act(p(HGNC:PPME1)) |
| pubmed:24653673 | act(p(HGNC:GSK3B)) increases p(HGNC:SET) |
| pubmed:12428809 | p(HGNC:GSK3B) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) |
| pubmed:12428809 | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:12428809 | p(HGNC:GSK3B) increases a(MESH:Axons) |
| pubmed:12428809 | p(HGNC:GSK3B) association bp(GO:"axonal transport") |
| pubmed:21734277 | act(p(HGNC:GSK3B)) decreases bp(GO:"axonal transport") |
| pubmed:21861815 | p(HGNC:GSK3B) increases p(HGNC:HIF1A, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30606258 | act(p(HGNC:GSK3B)) negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) |
| pubmed:30606258 | p(HGNC:GSK3B) association bp(GO:"regulation of insulin receptor signaling pathway") |
| pubmed:30606258 | p(HGNC:GSK3B) increases p(CONSO:"Tau isoform F (441 aa)", frag("187_441"), pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:30606258 | p(HGNC:GSK3B) increases p(CONSO:"Tau isoform F (441 aa)", frag("187_441"), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:27299292 | p(HGNC:GSK3B) decreases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) |
| pubmed:27299292 | p(HGNC:GSK3B) increases composite(p(HGNC:TFEB), p(HGNC:YWHAQ)) |
| pubmed:27299292 | act(p(HGNC:GSK3B)) decreases act(a(MESH:Lysosomes)) |
| pubmed:27299292 | p(HGNC:GSK3B) regulates act(a(MESH:Lysosomes)) |
| pubmed:27299292 | p(HGNC:GSK3B) regulates bp(GO:autophagy) |
| pubmed:21882945 | p(HGNC:GSK3B) increases act(p(HGNC:MARK2)) |
| pubmed:22419736 | act(p(HGNC:GSK3B)) negativeCorrelation p(FPLX:AMPK) |
| pubmed:30640040 | p(HGNC:GSK3B) association a(PUBCHEM:71295844) |
| pubmed:29191965 | p(HGNC:GSK3B) association path(MESH:Tauopathies) |
| pubmed:11812770 | p(HGNC:GSK3B) directlyIncreases complex(p(HGNC:GSK3B), p(HGNC:MAPT)) |
| pubmed:11812770 | p(HGNC:GSK3B) positiveCorrelation complex(p(HGNC:GSK3B), p(HGNC:MAPT)) |
| pubmed:11812770 | p(HGNC:GSK3B) directlyIncreases complex(p(HGNC:GSK3B), p(HGNC:MAPT, frag("1_244"))) |
| pubmed:11812770 | p(HGNC:GSK3B) directlyDecreases complex(p(HGNC:GSK3B), p(HGNC:MAPT, frag("245_369"))) |
| pubmed:11812770 | p(HGNC:GSK3B) directlyDecreases complex(p(HGNC:GSK3B), p(HGNC:MAPT, frag("245_441"))) |
| pubmed:14612456 | p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:17078951 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:19459590 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:18494933 | act(p(HGNC:GSK3B)) negativeCorrelation bp(GO:"Wnt signaling pathway") |
| pubmed:18494933 | act(p(HGNC:GSK3B)) increases p(GO:"neurofibrillary tangle") |
| pubmed:18494933 | act(p(HGNC:GSK3B)) negativeCorrelation bp(GO:"neuron development") |
| pubmed:12551948 | p(HGNC:GSK3B) isA complex(p(HGNC:GSK3B), p(HGNC:MAPT), p(HGNC:YWHAZ)) |
| pubmed:12551948 | p(HGNC:GSK3B) association p(HGNC:YWHAZ) |
| pubmed:23531502 | act(p(HGNC:GSK3B)) association a(CONSO:"Tau aggregates") |
| pubmed:7514173 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(FPLX:CREB, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:7514173 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MBP, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:7514173 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CSN3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:7514173 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:PPP1R2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:7514173 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CSNK2B, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:17078951 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) |
| pubmed:17078951 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:19459590 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:17078951 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 217)) |
| pubmed:17078951 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:17078951 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) |
| pubmed:9089387 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(FPLX:PDH, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:9089387 | p(HGNC:GSK3B) isA p(ECCODE:2.7.11.26) |
| pubmed:26501932 | p(HGNC:GSK3B) partOf a(CONSO:"GVD bodies") |
| pubmed:25331948 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(CONSO:"Tau epitope, PHF1") |
| pubmed:28176663 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) positiveCorrelation a(CONSO:"Braak_Stage I") |
| pubmed:28176663 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) positiveCorrelation a(CONSO:"Braak_Stage II") |
| pubmed:28176663 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) negativeCorrelation a(CONSO:"Braak_Stage V") |
| pubmed:24355211 | p(HGNC:GSK3B) positiveCorrelation bp(MESH:"Oxidative Stress") |
| pubmed:24355211 | p(HGNC:GSK3B) negativeCorrelation bp(GO:learning) |
| pubmed:24355211 | p(HGNC:GSK3B) negativeCorrelation bp(GO:memory) |
| pubmed:24355211 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:24355211 | act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 235)) |
| pubmed:27288790 | p(HGNC:GSK3A) causesNoChange r(HGNC:BACE1) |
| pubmed:30606258 | p(HGNC:GSK3A) increases p(CONSO:"Tau isoform F (441 aa)", frag("187_441"), pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:30606258 | p(HGNC:GSK3A) increases p(CONSO:"Tau isoform F (441 aa)", frag("187_441"), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:30640040 | p(HGNC:GSK3A) association a(PUBCHEM:71295844) |
| pubmed:22817713 | p(HGNC:GSK3A) decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:30837838 | p(HGNC:GSK3A) association p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27288790 | composite(p(HGNC:GSK3B), p(HGNC:RELA)) increases r(HGNC:BACE1) |
| pubmed:21722302 | p(HGNC:UCHL1) association bp(GO:"chaperone-mediated autophagy") |
| pubmed:30740335 | p(HGNC:UCHL1) association path(MESH:"Endoplasmic Reticulum Stress") |
| pubmed:14556719 | p(HGNC:UCHL1) decreases bp(GO:"protein ubiquitination") |
| pubmed:14556719 | p(HGNC:UCHL1) increases p(HGNC:SNCA, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:14556719 | p(HGNC:UCHL1) decreases path(MESH:"Deglutition Disorders") |
| pubmed:14556719 | p(HGNC:UCHL1) positiveCorrelation a(MESH:"Solitary Nucleus") |
| pubmed:14556719 | p(HGNC:UCHL1) positiveCorrelation a(MESH:"Area Postrema") |
| pubmed:22908190 | p(HGNC:UCHL1) association path(MESH:"Parkinson Disease") |
| pubmed:22908190 | p(HGNC:UCHL1) association path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | p(HGNC:UCHL1) increases act(a(GO:synapse)) |
| pubmed:22908190 | p(HGNC:UCHL1) increases bp(GO:memory) |
| pubmed:22908190 | p(HGNC:UCHL1) decreases bp(GO:"protein polyubiquitination") |
| pubmed:27288790 | a(MESH:Lipopolysaccharides) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pubmed:27288790 | a(MESH:Lipopolysaccharides) increases p(HGNC:TNF) |
| pubmed:27288790 | a(MESH:Lipopolysaccharides) increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27288790 | a(MESH:Lipopolysaccharides) increases p(HGNC:IL1B) |
| pubmed:27288790 | a(MESH:Lipopolysaccharides) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30967783 | a(MESH:Lipopolysaccharides) increases a(NCIT:C156004) |
| pubmed:26445701 | a(MESH:Chemokines) increases bp(MESH:"Transendothelial and Transepithelial Migration") |
| pubmed:30967783 | a(MESH:Chemokines) increases a(MESH:"Leukocytes, Mononuclear", loc(NCIT:C74601)) |
| pubmed:30967783 | a(MESH:Chemokines, loc(NCIT:C74601)) increases a(MESH:Macrophages, loc(MESH:Brain)) |
| pubmed:26979166 | a(MESH:Chemokines) increases deg(a(MESH:"White Matter")) |
| pubmed:26979166 | a(MESH:Chemokines) increases deg(a(MESH:"Gray Matter")) |
| pubmed:30988501 | a(MESH:Chemokines) increases bp(GO:"central nervous system development") |
| pubmed:27288790 | m(MIRBASE:hsa-mir-125b-1) decreases r(HGNC:ALOX15) |
| pubmed:27288790 | m(MIRBASE:hsa-mir-125b-1) decreases r(HGNC:VDR) |
| pubmed:25001178 | m(MIRBASE:hsa-mir-125b-1) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:25001178 | m(MIRBASE:hsa-mir-125b-1) increases act(p(HGNC:CDK5R1)) |
| pubmed:25001178 | m(MIRBASE:hsa-mir-125b-1) increases act(p(HGNC:CDK5), ma(go:0016301 ! "kinase activity")) |
| pubmed:25001178 | m(MIRBASE:hsa-mir-125b-1) increases act(p(HGNC:MAPK3), ma(go:0016301 ! "kinase activity")) |
| pubmed:25001178 | m(MIRBASE:hsa-mir-125b-1) increases act(p(HGNC:MAPK1), ma(go:0016301 ! "kinase activity")) |
| pubmed:25001178 | m(MIRBASE:hsa-mir-125b-1) decreases p(HGNC:PPP1CA) |
| pubmed:25001178 | m(MIRBASE:hsa-mir-125b-1) decreases p(HGNC:DUSP6) |
| pubmed:25001178 | m(MIRBASE:hsa-mir-125b-1) decreases p(HGNC:DUSP6) |
| pubmed:25001178 | m(MIRBASE:hsa-mir-125b-1) decreases p(HGNC:BCL2L2) |
| pubmed:27288790 | m(MIRBASE:hsa-mir-125b-2) decreases r(HGNC:ALOX15) |
| pubmed:27288790 | m(MIRBASE:hsa-mir-125b-2) decreases r(HGNC:VDR) |
| pubmed:27288790 | m(MIRBASE:hsa-mir-146a) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27288790 | m(MIRBASE:hsa-mir-146a) association r(HGNC:IRAK1) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-146a) decreases r(HGNC:IRAK1) |
| pubmed:27288790 | m(MIRBASE:hsa-mir-146a) association bp(GO:"immune response") |
| pubmed:27288790 | m(MIRBASE:hsa-mir-146a) increases path(HP:Neurodegeneration) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-146a) association a(MESH:"Neural Pathways") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-146a) association a(MESH:"Immune System") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-146a) negativeCorrelation p(OMIT:0016854) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-146a) decreases p(HGNCGENEFAMILY:"Toll like receptors") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-146a) decreases p(HGNC:IL1R1) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-146a) decreases p(HGNC:TRAF6) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-146a) decreases p(HGNC:IRAK1) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-146a) decreases r(HGNC:TRAF6) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-146a) decreases p(HGNC:NLRP3) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-146a) decreases r(HGNC:NLRP3) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-146a) decreases p(HGNC:PYCARD) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-146a) decreases r(HGNC:PYCARD) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-146a) decreases p(HGNC:CASP1) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-146a) decreases r(HGNC:CASP1) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-146a) directlyDecreases path(OMIT:0016001) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-146a) regulates complex(MESH:Inflammasomes) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-146a) negativeCorrelation path(DOID:"rheumatoid arthritis") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-146a) negativeCorrelation path(DOID:"multiple sclerosis") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-146a) negativeCorrelation path(DOID:"systemic lupus erythematosus") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-146a, loc(MESH:"T-Lymphocytes, Regulatory")) association path(DOID:arthritis) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-146a) association bp(GO:"glomerular filtration") |
| pubmed:27288790 | m(MIRBASE:hsa-mir-155) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27288790 | m(MIRBASE:hsa-mir-155) positiveCorrelation path(MESH:"Multiple Sclerosis") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-155) negativeCorrelation p(OMIT:0016854) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-155) decreases p(HGNCGENEFAMILY:"Toll like receptors") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-155) decreases p(HGNC:IL1R1) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-155) decreases p(HGNC:MYD88) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-155) decreases r(HGNC:NFKB1) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-155) regulates complex(MESH:Inflammasomes) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-155) negativeCorrelation path(DOID:"rheumatoid arthritis") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-155) negativeCorrelation path(DOID:"multiple sclerosis") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-155) negativeCorrelation path(DOID:"systemic lupus erythematosus") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-155) association path(DOID:proteinuria) |
| pubmed:27288790 | r(HGNC:IRAK1) association m(MIRBASE:hsa-mir-146a) |
| pubmed:27288790 | path(MESH:"Multiple Sclerosis") positiveCorrelation m(MIRBASE:hsa-mir-155) |
| pubmed:27794524 | path(MESH:"Multiple Sclerosis") isA path(MESH:"Central Nervous System Diseases") |
| pubmed:27956442 | path(MESH:"Multiple Sclerosis") isA path(MESH:"Central Nervous System Diseases") |
| pubmed:27794524 | path(MESH:"Multiple Sclerosis") increases path(MESH:"Demyelinating Diseases") |
| pubmed:27794524 | path(MESH:"Multiple Sclerosis") increases path(MESH:"Neurodegenerative Diseases") |
| pubmed:27794524 | path(MESH:"Multiple Sclerosis") association path(MESH:Autoimmunity) |
| pubmed:27794524 | path(MESH:"Multiple Sclerosis") increases path(MESH:"Multiple Sclerosis, Relapsing-Remitting") |
| pubmed:27794524 | path(MESH:"Multiple Sclerosis") increases a(MESH:"CD8-Positive T-Lymphocytes") |
| pubmed:27794524 | path(MESH:"Multiple Sclerosis") decreases act(p(MESH:"Electron Transport Chain Complex Proteins")) |
| pubmed:27794524 | path(MESH:"Multiple Sclerosis") decreases p(MESH:"Molecular Motor Proteins") |
| pubmed:27794524 | path(MESH:"Multiple Sclerosis") directlyDecreases a(PUBCHEM:65065) |
| pubmed:27794524 | path(MESH:"Multiple Sclerosis") positiveCorrelation p(HGNC:LINGO1) |
| pubmed:27956442 | path(MESH:"Multiple Sclerosis") association path(MESH:Inflammation) |
| pubmed:27956442 | path(MESH:"Multiple Sclerosis") association a(MESH:"Motor Neurons") |
| pubmed:27956442 | path(MESH:"Multiple Sclerosis") association path(MESH:Sensation) |
| pubmed:27956442 | path(MESH:"Multiple Sclerosis") association path(MESH:"Visual Perception") |
| pubmed:27956442 | path(MESH:"Multiple Sclerosis") association path(MESH:"Autonomic Nervous System") |
| pubmed:27956442 | path(MESH:"Multiple Sclerosis") association path(MESH:"Optic Neuritis") |
| pubmed:27956442 | path(MESH:"Multiple Sclerosis") association path(MESH:"Body Temperature Changes") |
| pubmed:27956442 | path(MESH:"Multiple Sclerosis") association path(NCIT:C28314) |
| pubmed:27956442 | path(MESH:"Multiple Sclerosis") positiveCorrelation path(MESH:"Epstein-Barr Virus Infections") |
| pubmed:27956442 | path(MESH:"Multiple Sclerosis") positiveCorrelation path(MESH:"Infectious Mononucleosis") |
| pubmed:27956442 | path(MESH:"Multiple Sclerosis") positiveCorrelation path(MESH:Smoking) |
| pubmed:22950410 | path(MESH:"Multiple Sclerosis") association p(HGNC:CRHR1) |
| pubmed:27288790 | a(CHEBI:"(+)-Tetrandrine") decreases act(p(FPLX:NFkappaB)) |
| pubmed:27288790 | a(CHEBI:"(+)-Tetrandrine") decreases r(HGNC:NOS2) |
| pubmed:27288790 | a(CHEBI:"(+)-Tetrandrine") decreases r(HGNC:PTGS2) |
| pubmed:27288790 | a(MESH:Morphine) decreases act(p(FPLX:NFkappaB)) |
| pubmed:27288790 | a(MESH:Morphine) increases p(FPLX:IKB) |
| pubmed:27288790 | a(PUBCHEM:439378) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:27288790 | a(PUBCHEM:439378) decreases p(FPLX:ERK) |
| pubmed:27288790 | a(PUBCHEM:439378) decreases p(HGNC:MAPK14) |
| pubmed:27288790 | a(PUBCHEM:439378) decreases p(FPLX:NFkappaB) |
| pubmed:27288790 | a(PUBCHEM:3968) decreases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 42)) |
| pubmed:27288790 | a(PUBCHEM:3968) decreases act(p(FPLX:NFkappaB)) |
| pubmed:27288790 | a(CHEBI:melatonin) decreases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 42)) |
| pubmed:27288790 | a(CHEBI:melatonin) decreases act(p(FPLX:NFkappaB)) |
| pubmed:27288790 | a(CHEBI:naproxen) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") |
| pubmed:27288790 | a(CHEBI:naproxen) decreases r(HGNC:BACE1) |
| pubmed:27288790 | a(CHEBI:naproxen) decreases a(CHEBI:amyloid-beta) |
| pubmed:27288790 | a(CHEBI:hydroxytyrosol) decreases act(p(FPLX:NFkappaB)) |
| pubmed:27288790 | a(CHEBI:nicorandil) decreases bp(GO:"apoptotic process") |
| pubmed:27288790 | a(CHEBI:nicorandil) decreases path(MESH:"Oxidative Stress") |
| pubmed:27288790 | a(CHEBI:nicorandil) decreases p(CONSO:APP695) |
| pubmed:27288790 | a(CHEBI:nicorandil) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:10656250 | p(CONSO:APP695) association p(HGNC:BACE1) |
| pubmed:27288790 | a(PUBCHEM:6440944) decreases act(p(FPLX:ERK)) |
| pubmed:27288790 | a(PUBCHEM:6440944) decreases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27288790 | a(PUBCHEM:6440944) decreases p(FPLX:NFkappaB, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27288790 | a(PUBCHEM:6440944) decreases act(p(FPLX:NFkappaB)) |
| pubmed:27288790 | a(PUBCHEM:6440944) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27288790 | a(PUBCHEM:6440944) decreases p(HGNC:APP) |
| pubmed:27288790 | a(PUBCHEM:6440944) decreases a(CHEBI:amyloid-beta) |
| pubmed:27288790 | a(PUBCHEM:6440944) decreases tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:25652642 | complex(a(GO:"NF-kappaB complex"), p(HGNC:NFKB1), p(HGNC:RELA), loc(GO:nucleus)) increases act(complex(GO:"NF-kappaB p50/p65 complex")) |
| pubmed:25652642 | bp(GO:"membrane depolarization") increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:17009926 | bp(GO:"membrane depolarization") increases act(complex(GO:"voltage-gated calcium channel complex")) |
| pubmed:29428175 | bp(GO:"membrane depolarization") increases complex(GO:"voltage-gated calcium channel complex") |
| pubmed:26813123 | bp(GO:"membrane depolarization") regulates act(p(HGNC:CHAT)) |
| pubmed:26813123 | bp(GO:"membrane depolarization") increases tloc(a(CHEBI:acetylcholine), fromLoc(MESH:"Synaptic Vesicles"), toLoc(GO:"synaptic cleft")) |
| pubmed:26813123 | bp(GO:"membrane depolarization") increases complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) |
| pubmed:30697142 | bp(GO:"membrane depolarization") increases bp(GO:"calcium ion import") |
| pubmed:25652642 | bp(GO:"synaptic transmission, glutamatergic") increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:19419557 | bp(GO:"synaptic transmission, glutamatergic") association a(CHEBI:"glutamate(2-)") |
| pubmed:24511233 | bp(GO:"synaptic transmission, glutamatergic") association path(MESH:Schizophrenia) |
| pubmed:26813123 | bp(GO:"synaptic transmission, glutamatergic") association bp(GO:cognition) |
| pubmed:30697142 | bp(GO:"synaptic transmission, glutamatergic") positiveCorrelation bp(GO:cognition) |
| pubmed:26813123 | bp(GO:"synaptic transmission, glutamatergic") association path(CONSO:Neurodegeneration) |
| pubmed:30106381 | bp(GO:"synaptic transmission, glutamatergic") positiveCorrelation p(HGNC:ADNP) |
| pubmed:27013968 | bp(GO:"synaptic transmission, glutamatergic") negativeCorrelation p(HGNC:HTT, pmod(HBP:"CAG repeats")) |
| pubmed:30988501 | bp(GO:"synaptic transmission, glutamatergic") increases path(CONSO:neurotoxicity) |
| pubmed:25652642 | bp(GO:"calmodulin dependent kinase signaling pathway") increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:25652642 | bp(GO:"phosphatidylinositol 3-kinase signaling") increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:19126755 | bp(GO:"phosphatidylinositol 3-kinase signaling") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:18986241 | bp(GO:"phosphatidylinositol 3-kinase signaling") regulates bp(MESH:"Cell Survival") |
| pubmed:18986241 | bp(GO:"phosphatidylinositol 3-kinase signaling") association p(FPLX:RAS) |
| pubmed:18986241 | bp(GO:"phosphatidylinositol 3-kinase signaling") association p(HGNC:IRS1) |
| pubmed:18986241 | bp(GO:"phosphatidylinositol 3-kinase signaling") association p(HGNC:GAB1) |
| pubmed:22040696 | bp(GO:"phosphatidylinositol 3-kinase signaling") decreases bp(GO:"neuron death") |
| pubmed:22040696 | bp(GO:"phosphatidylinositol 3-kinase signaling") increases p(FPLX:CHRN) |
| pubmed:25652642 | complex(complex(GO:"NF-kappaB complex"), p(FPLX:IKB), loc(GO:cytoplasm)) directlyDecreases act(complex(GO:"NF-kappaB complex")) |
| pubmed:25652642 | p(CONSO:sAPP-beta) positiveCorrelation act(complex(GO:"NF-kappaB complex")) |
| pubmed:19293145 | p(CONSO:sAPP-beta) decreases act(a(CHEBI:amyloid-beta)) |
| pubmed:25652642 | act(p(HGNC:APOE)) association complex(GO:"NF-kappaB complex") |
| pubmed:21769591 | p(HGNC:APOE) association path(MESH:"Alzheimer Disease") |
| pubmed:22159054 | p(HGNC:APOE) association path(MESH:"Alzheimer Disease") |
| pubmed:30106381 | p(HGNC:APOE) increases path(MESH:"Alzheimer Disease") |
| pubmed:24080518 | p(HGNC:APOE) association a(NIFT:"Cortical Thinning") |
| pubmed:21504134 | p(HGNC:APOE) negativeCorrelation a(NIFT:"Cortical Thickness") |
| pubmed:22550605 | p(HGNC:APOE) increases a(NIFT:"Grey matter atrophy") |
| pubmed:19293145 | p(HGNC:APOE) association bp(GO:"lipid metabolic process") |
| pubmed:19293145 | p(HGNC:APOE) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:21718217 | p(HGNC:APOE) increases a(CHEBI:"high-density lipoprotein") |
| pubmed:21718217 | p(HGNC:APOE) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:21718217 | act(p(HGNC:APOE)) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:26195256 | act(p(HGNC:APOE)) regulates a(CHEBI:amyloid-beta) |
| pubmed:26195256 | tloc(p(HGNC:APOE), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Cardiovascular System")) negativeCorrelation tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Cardiovascular System")) |
| pubmed:26195256 | p(HGNC:APOE) regulates deg(a(CHEBI:amyloid-beta)) |
| pubmed:30106381 | p(HGNC:APOE) association a(PUBCHEM:9832404) |
| pubmed:31413141 | p(HGNC:APOE) association r(DBSNP:rs769449) |
| pubmed:31413141 | p(HGNC:APOE) causesNoChange p(HGNC:TREM2, frag("?")) |
| pubmed:25652642 | composite(a(MESH:"amyloid beta-protein (25-35)"), complex(GO:"NF-kappaB complex")) increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:25652642 | composite(a(MESH:"amyloid beta-protein (25-35)"), complex(GO:"NF-kappaB complex")) increases tloc(p(HGNC:NGF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:25652642 | composite(a(MESH:"amyloid beta-protein (25-35)"), complex(GO:"NF-kappaB complex")) increases tloc(p(HGNC:BDNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:25652642 | a(MESH:"amyloid beta-protein (25-35)") increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:26551702 | act(p(HGNC:NGF)) increases act(p(FPLX:NFkappaB)) |
| pubmed:19126755 | act(p(HGNC:NGF)) increases bp(GO:"MAPK cascade") |
| pubmed:18986241 | act(p(HGNC:NGF)) increases bp(GO:"MAPK cascade") |
| pubmed:23393546 | p(HGNC:NGF) increases bp(GO:"MAPK cascade") |
| pubmed:19126755 | act(p(HGNC:NGF)) increases complex(p(HGNC:JUN), p(HGNC:SP1)) |
| pubmed:19126755 | p(HGNC:NGF) regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:18986241 | p(HGNC:NGF) isA a(MESH:"Nerve Growth Factors") |
| pubmed:18986241 | p(HGNC:NGF) causesNoChange path(MESH:"Diabetic Neuropathies") |
| pubmed:18986241 | p(HGNC:NGF) causesNoChange path(MESH:"AIDS-Associated Nephropathy") |
| pubmed:18986241 | p(HGNC:NGF) causesNoChange path(MESH:"Alzheimer Disease") |
| pubmed:18986241 | p(HGNC:NGF) association bp(GO:innervation) |
| pubmed:18986241 | p(HGNC:NGF) association bp(GO:"neurotransmitter secretion") |
| pubmed:18986241 | p(HGNC:NGF) association bp(GO:"sympathetic nervous system development") |
| pubmed:18986241 | p(HGNC:NGF) association path(MESH:Cachexia) |
| pubmed:18986241 | p(HGNC:NGF) association path(MESH:Hyperalgesia) |
| pubmed:18986241 | p(HGNC:NGF) decreases path(MESH:"Cognitive Dysfunction") |
| pubmed:25652642 | p(HGNC:GRM5) increases complex(a(GO:"NF-kappaB complex"), a(GO:"NF-kappaB complex"), p(HGNC:REL)) |
| pubmed:25652642 | p(HGNC:GRM5) increases act(p(HGNC:SOD2)) |
| pubmed:25652642 | p(HGNC:GRM5) increases act(p(HGNC:BCL2L1)) |
| pubmed:24653673 | p(HGNC:GRM5) association path(MESH:"Alzheimer Disease") |
| pubmed:25652642 | complex(a(GO:"NF-kappaB complex"), a(GO:"NF-kappaB complex"), p(HGNC:REL)) decreases act(a(CHEBI:amyloid-beta)) |
| pubmed:25652642 | complex(a(GO:"NF-kappaB complex"), p(HGNC:RELA)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22236693 | deg(a(MESH:"Cholinergic Neurons")) regulates bp(GO:cognition) |
| pubmed:19293145 | a(MESH:"Cholinergic Neurons") increases act(p(HGNC:CHAT)) |
| pubmed:26813123 | act(a(MESH:"Cholinergic Neurons")) increases path(MESH:Attention) |
| pubmed:26813123 | a(MESH:"Cholinergic Neurons") increases path(MESH:Attention) |
| pubmed:26813123 | a(MESH:"Cholinergic Neurons") positiveCorrelation bp(GO:memory) |
| pubmed:26813123 | a(MESH:"Cholinergic Neurons") increases bp(GO:memory) |
| pubmed:26813123 | a(MESH:"Cholinergic Neurons") increases bp(GO:"circadian sleep/wake cycle, REM sleep") |
| pubmed:26813123 | a(MESH:"Cholinergic Neurons") increases a(CHEBI:acetylcholine) |
| pubmed:26813123 | a(MESH:"Cholinergic Neurons") increases a(CHEBI:choline) |
| pubmed:26813123 | a(MESH:"Cholinergic Neurons") increases tloc(p(HGNC:ACHE), fromLoc(MESH:"Synaptic Vesicles"), toLoc(GO:"synaptic cleft")) |
| pubmed:26813123 | a(MESH:"Cholinergic Neurons") increases bp(GO:"synaptic transmission, dopaminergic") |
| pubmed:26813123 | a(MESH:"Cholinergic Neurons") decreases path(MESH:Apathy) |
| pubmed:26813123 | a(MESH:"Cholinergic Neurons") decreases path(MESH:Depression) |
| pubmed:26813123 | a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26813123 | a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Parkinson Disease") |
| pubmed:26813123 | a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Down Syndrome") |
| pubmed:26813123 | a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:26813123 | a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pubmed:26813123 | a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Olivopontocerebellar Atrophies") |
| pubmed:26813123 | a(MESH:"Cholinergic Neurons") association act(p(HGNC:CHRM1)) |
| pubmed:26979166 | a(MESH:"Cholinergic Neurons") increases complex(CONSO:"alpha-7 beta-2 nAChR") |
| pubmed:28901280 | a(MESH:"Cholinergic Neurons") increases a(MESH:Acetylcholine) |
| pubmed:25652642 | bp(GO:"positive regulation of advanced glycation end-product receptor activity") increases act(a(MESH:Microglia)) |
| pubmed:25652642 | bp(GO:"peroxisome proliferator activated receptor signaling pathway") increases act(a(MESH:Microglia)) |
| pubmed:27299292 | bp(GO:"peroxisome proliferator activated receptor signaling pathway") regulates act(p(HGNC:TFEB)) |
| pubmed:27299292 | bp(GO:"peroxisome proliferator activated receptor signaling pathway") regulates bp(GO:"lipid catabolic process") |
| pubmed:25652642 | p(MESH:"I-kappa B Proteins", pmod(go:0006468 ! "protein phosphorylation")) increases act(a(MESH:Microglia)) |
| pubmed:25652642 | a(MESH:"HLA-DR Antigens") association path(MESH:"Plaque, Amyloid") |
| pubmed:25652642 | a(MESH:"HLA-DR Antigens") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25652642 | m(HGNC:MIR9-1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25652642 | m(HGNC:MIR34A) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25652642 | m(HGNC:MIR125B1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25652642 | m(HGNC:MIR125B1) positiveCorrelation p(HGNC:GFAP) |
| pubmed:25652642 | m(HGNC:MIR125B1) positiveCorrelation p(HGNC:VIM) |
| pubmed:25652642 | m(HGNC:MIR125B1) positiveCorrelation p(HGNC:CDKN2A) |
| pubmed:25652642 | m(HGNC:MIR146A) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24586483 | m(HGNC:MIR146A) association path(MESH:"Alzheimer Disease") |
| pubmed:24586483 | m(HGNC:MIR146A) association path(MESH:"Alzheimer Disease") |
| pubmed:24586483 | m(HGNC:MIR146A) regulates path(MESH:Inflammation) |
| pubmed:24586483 | m(HGNC:MIR146A) association path(CONSO:neuroinflammation) |
| pubmed:24586483 | m(HGNC:MIR146A) association bp(GO:"amyloid precursor protein metabolic process") |
| pubmed:25652642 | m(HGNC:MIR155) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25652642 | m(HGNC:MIR339) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25652642 | p(HGNC:VIM) positiveCorrelation m(HGNC:MIR125B1) |
| pubmed:25652642 | p(HGNC:CDKN2A) positiveCorrelation m(HGNC:MIR125B1) |
| pubmed:30126037 | p(HGNC:CDKN2A) association a(GO:"neurofibrillary tangle") |
| pubmed:30126037 | p(HGNC:CDKN2A) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pubmed:30126037 | p(HGNC:CDKN2A) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pubmed:30126037 | p(HGNC:CDKN2A) association bp(HP:Neurodegeneration) |
| pubmed:30126037 | p(HGNC:CDKN2A) association path(MESH:"Cognitive Dysfunction") |
| pubmed:26551702 | act(p(HGNC:NFE2L2), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates r(HGNC:NQO1) |
| pubmed:26551702 | act(p(HGNC:NFE2L2), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates r(FPLX:HMOX) |
| pubmed:26551702 | act(p(HGNC:NFE2L2), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates r(HGNC:GCLM) |
| pubmed:26551702 | act(p(HGNC:NFE2L2), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates r(HGNC:GCLC) |
| pubmed:26551702 | act(p(HGNC:NFE2L2), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates r(HGNCGENEFAMILY:"Ferritin subunits") |
| pubmed:26551702 | p(HGNC:NFE2L2) association bp(GO:"glucose metabolic process") |
| pubmed:26551702 | p(HGNC:NFE2L2) regulates bp(GO:"pentose-phosphate shunt") |
| pubmed:26551702 | p(HGNC:NFE2L2, loc(MESH:"Cell Nucleus")) increases complex(p(FPLX:MAF), p(HGNC:NFE2L2)) |
| pubmed:26551702 | p(HGNC:NFE2L2, loc(MESH:"Cell Nucleus")) increases complex(g(MESH:"Antioxidant Response Elements"), p(HGNC:NFE2L2)) |
| pubmed:26551702 | tloc(p(HGNC:NFE2L2), fromLoc(MESH:"Cell Nucleus"), toLoc(MESH:Cytosol)) increases deg(p(HGNC:NFE2L2)) |
| pubmed:26551702 | p(HGNC:NFE2L2) decreases path(MESH:"Neurodegenerative Diseases") |
| pubmed:26551702 | p(HGNC:NFE2L2) positiveCorrelation a(MESH:Cytokines) |
| pubmed:26551702 | p(HGNC:NFE2L2) decreases act(p(HGNC:IKBKB)) |
| pubmed:26551702 | act(p(HGNC:NFE2L2)) decreases p(HGNC:PTGS2) |
| pubmed:26551702 | act(p(HGNC:NFE2L2)) decreases p(HGNC:TNF) |
| pubmed:26551702 | act(p(HGNC:NFE2L2)) decreases p(HGNC:NOS2) |
| pubmed:26551702 | act(p(HGNC:NFE2L2)) increases a(MESH:Glutathione) |
| pubmed:26551702 | p(HGNC:NFE2L2) regulates act(p(FPLX:NFkappaB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:26551702 | act(p(HGNC:NFE2L2), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases p(FPLX:HMOX) |
| pubmed:26551702 | act(p(HGNC:NFE2L2), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases p(HGNC:SQSTM1) |
| pubmed:26551702 | p(HGNC:NFE2L2) decreases p(HGNC:MAFK) |
| pubmed:30988501 | p(HGNC:NFE2L2) increases act(a(CHEBI:"dimethyl fumarate"), ma(GO:"antioxidant activity")) |
| pubmed:27794524 | p(HGNC:NFE2L2) decreases path(MESH:"Oxidative Stress") |
| pubmed:26445701 | act(p(HGNC:NFE2L2)) decreases path(MESH:Inflammation) |
| pubmed:30515821 | p(HGNC:NFE2L2) increases a(MESH:Mitochondria) |
| pubmed:22020111 | act(p(HGNC:NFE2L2)) increases g(HGNC:HMOX1) |
| pubmed:22020111 | act(p(HGNC:NFE2L2)) negativeCorrelation path(MESH:"Kidney Diseases") |
| pubmed:22020111 | act(p(HGNC:NFE2L2)) negativeCorrelation path(MESH:"Multiple Sclerosis, Relapsing-Remitting") |
| pubmed:30688256 | p(HGNC:NFE2L2) regulates a(CHEBI:"reactive oxygen species") |
| pubmed:28148553 | p(HGNC:NFE2L2) association p(HGNC:EIF2AK3) |
| pubmed:28148553 | p(HGNC:NFE2L2) regulates p(HGNC:HMOX1) |
| pubmed:28148553 | p(HGNC:NFE2L2) regulates bp(GO:"iron ion homeostasis") |
| pubmed:21722302 | p(HGNC:NFE2L2) increases a(MESH:"Molecular Chaperones") |
| pubmed:24563850 | p(HGNC:NFE2L2) increases bp(CONSO:Proteostasis) |
| pubmed:29121589 | p(HGNC:NFE2L2) partOf complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) |
| pubmed:29121589 | p(HGNC:NFE2L2) positiveCorrelation p(FPLX:AKT) |
| pubmed:29121589 | p(HGNC:NFE2L2) negativeCorrelation act(p(HGNC:GSK3B)) |
| pubmed:24355211 | p(HGNC:NFE2L2) increases p(ECCODE:2.5.1.18) |
| pubmed:26551702 | bp(GO:"glucose metabolic process") association p(HGNC:NFE2L2) |
| pubmed:23300102 | bp(GO:"glucose metabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21861815 | bp(GO:"glucose metabolic process") negativeCorrelation path(DOID:"Alzheimer's disease") |
| pubmed:30985105 | bp(GO:"glucose metabolic process") association p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:26551702 | complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:RBX1)) regulates p(HGNC:NFE2L2) |
| pubmed:26551702 | complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:RBX1)) increases p(HGNC:NFE2L2, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:29121589 | p(HGNC:CUL3) partOf complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) |
| pubmed:26551702 | p(HGNC:KEAP1) increases deg(p(HGNC:NFE2L2)) |
| pubmed:26551702 | p(HGNC:KEAP1) decreases p(HGNC:NFE2L2, loc(MESH:Cytosol)) |
| pubmed:24563850 | act(p(HGNC:KEAP1)) increases deg(p(HGNC:NFE2L2)) |
| pubmed:26551702 | p(HGNC:KEAP1) decreases act(p(HGNC:IKBKB)) |
| pubmed:26551702 | p(HGNC:KEAP1) increases complex(p(FPLX:HSP90), p(HGNC:IKBKB)) |
| pubmed:26551702 | p(HGNC:KEAP1) decreases p(HGNC:IKBKB, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29121589 | p(HGNC:KEAP1) increases complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) |
| pubmed:29121589 | p(HGNC:KEAP1) isA p(ECCODE:2.3.2.27) |
| pubmed:26551702 | p(HGNC:NFE2L2, pmod(go:0016567 ! "protein ubiquitination")) increases deg(p(HGNC:NFE2L2)) |
| pubmed:29121589 | p(HGNC:NFE2L2, pmod(go:0016567 ! "protein ubiquitination")) regulates deg(p(HGNC:NFE2L2)) |
| pubmed:26551702 | bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:NFE2L2)) |
| pubmed:25031639 | bp(GO:"proteasomal protein catabolic process") negativeCorrelation p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:26631930 | bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination"))) |
| pubmed:22908190 | bp(GO:"proteasomal protein catabolic process") negativeCorrelation bp(GO:autophagy) |
| pubmed:22908190 | bp(GO:"proteasomal protein catabolic process") decreases a(MESH:Proteins) |
| pubmed:22908190 | bp(GO:"proteasomal protein catabolic process") association p(HGNC:SQSTM1) |
| pubmed:24027553 | bp(GO:"proteasomal protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26631930 | bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT)) |
| pubmed:29626319 | bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT)) |
| pubmed:26631930 | bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT, pmod(go:0070534 ! "protein K63-linked ubiquitination"))) |
| pubmed:26551702 | complex(p(HGNC:KEAP1), p(HGNC:NFE2L2)) decreases p(HGNC:NFE2L2, loc(MESH:"Cell Nucleus")) |
| pubmed:26551702 | a(CHEBI:"phenolic radical") decreases complex(p(HGNC:KEAP1), p(HGNC:NFE2L2)) |
| pubmed:26551702 | p(HGNC:BTRC) increases deg(p(HGNC:NFE2L2)) |
| pubmed:26551702 | p(HGNC:BTRC) regulates p(HGNC:NFE2L2, loc(MESH:Cytosol)) |
| pubmed:26551702 | p(HGNC:BTRC) decreases act(p(HGNC:NFE2L2), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:26551702 | p(HGNC:BTRC) increases deg(p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:26551702 | act(p(HGNC:BTRC)) regulates deg(p(HGNC:NFKBIA)) |
| pubmed:26551702 | p(HGNC:BTRC) increases act(p(FPLX:NFkappaB)) |
| pubmed:25546293 | act(p(HGNC:BTRC), ma(GO:"ubiquitin protein ligase activity")) increases p(HGNC:CTNNB1, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:29121589 | p(HGNC:BTRC) increases complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:29121589 | p(HGNC:BTRC) isA p(ECCODE:2.3.2.27) |
| pubmed:17009926 | bp(GO:"developmental process") association p(FPLX:CHRN) |
| pubmed:22110360 | bp(GO:"cell population proliferation") association act(p(HGNC:DYRK1A)) |
| pubmed:26551702 | a(CHEBI:lipopolysaccharide) increases act(p(FPLX:NFkappaB)) |
| pubmed:26551702 | a(CHEBI:lipopolysaccharide) increases act(p(FPLX:NFkappaB)) |
| pubmed:26551702 | a(CHEBI:lipopolysaccharide) increases act(p(HGNC:RAC1)) |
| pubmed:30515821 | a(CHEBI:lipopolysaccharide) increases act(a(NCIT:C12616)) |
| pubmed:22807490 | a(CHEBI:lipopolysaccharide) increases bp(GO:"macrophage activation") |
| pubmed:23178521 | a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:lipopolysaccharide) increases p(HGNC:IL1B) |
| pubmed:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b) |
| pubmed:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b) |
| pubmed:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b) |
| pubmed:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) |
| pubmed:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) |
| pubmed:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) |
| pubmed:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) |
| pubmed:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) |
| pubmed:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) |
| pubmed:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25672970 | a(CHEBI:lipopolysaccharide) increases bp(GO:"neuroinflammatory response") |
| pubmed:19323834 | a(CHEBI:lipopolysaccharide) decreases p(HGNC:SUMO1) |
| pubmed:26551702 | complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFKBIA), p(HGNC:SKP1)) increases p(HGNC:NFKBIA, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:26551702 | complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFKBIA), p(HGNC:SKP1)) increases deg(p(HGNC:NFKBIA)) |
| pubmed:29121589 | p(HGNC:CUL1) partOf complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:26551702 | act(a(MESH:Mitochondria)) increases a(CHEBI:radical) |
| pubmed:30515821 | a(MESH:Mitochondria) association a(CHEBI:N-methyl-4-phenylpyridinium) |
| pubmed:22299660 | a(MESH:Mitochondria) association p(FPLX:PPP2) |
| pubmed:30126037 | act(a(MESH:Mitochondria)) association bp(GO:"cellular respiration") |
| pubmed:30837838 | a(MESH:Mitochondria) association p(HGNC:CHCHD10) |
| pubmed:24563850 | a(CHEBI:radical) association bp(GO:"detection of redox state") |
| pubmed:24563850 | a(CHEBI:radical) regulates bp(GO:"intracellular receptor signaling pathway") |
| pubmed:24563850 | a(CHEBI:radical) regulates bp(MESH:Metabolism) |
| pubmed:24563850 | a(CHEBI:radical) decreases a(MESH:Antioxidants) |
| pubmed:24563850 | a(CHEBI:radical) association bp(MESH:"Host-Pathogen Interactions") |
| pubmed:24563850 | a(CHEBI:radical) increases bp(CONSO:"non-enzymatic protein modification") |
| pubmed:24563850 | a(CHEBI:radical) increases bp(CONSO:misfolding) |
| pubmed:24563850 | a(CHEBI:radical) increases bp(MESH:"Protein Carbonylation") |
| pubmed:27794524 | path(MESH:"Neurodegenerative Diseases") positiveCorrelation bp(GO:"inflammatory response") |
| pubmed:27794524 | path(MESH:"Neurodegenerative Diseases") positiveCorrelation path(MESH:"Tertiary Lymphoid Structures") |
| pubmed:30061532 | path(MESH:"Neurodegenerative Diseases") positiveCorrelation act(p(HGNC:MTOR)) |
| pubmed:18986241 | path(MESH:"Neurodegenerative Diseases") association path(MESH:"Alzheimer Disease") |
| pubmed:22040696 | path(MESH:"Neurodegenerative Diseases") association p(HGNC:CHRNA7) |
| pubmed:30688256 | path(MESH:"Neurodegenerative Diseases") association p(HGNC:PINK1) |
| pubmed:30362565 | path(MESH:"Neurodegenerative Diseases") association path(MESH:"Huntington Disease") |
| pubmed:29687724 | path(MESH:"Neurodegenerative Diseases") association path(MESH:"Huntington Disease") |
| pubmed:21722302 | path(MESH:"Neurodegenerative Diseases") association bp(GO:autophagy) |
| pubmed:18930136 | path(MESH:"Neurodegenerative Diseases") association bp(GO:autophagy) |
| pubmed:18930136 | path(MESH:"Neurodegenerative Diseases") negativeCorrelation bp(GO:autophagy) |
| pubmed:21722302 | path(MESH:"Neurodegenerative Diseases") association bp(CONSO:"protein aggregation") |
| pubmed:21722302 | path(MESH:"Neurodegenerative Diseases") increases bp(CONSO:"protein aggregation") |
| pubmed:21722302 | path(MESH:"Neurodegenerative Diseases") association bp(MESH:"Endoplasmic Reticulum Stress") |
| pubmed:21722302 | path(MESH:"Neurodegenerative Diseases") association path(HP:"Senile plaques") |
| pubmed:21722302 | path(MESH:"Neurodegenerative Diseases") association bp(MESH:"Unfolded Protein Response") |
| pubmed:30562574 | path(MESH:"Neurodegenerative Diseases") association bp(GO:"chaperone-mediated autophagy") |
| pubmed:29311797 | path(MESH:"Neurodegenerative Diseases") negativeCorrelation bp(GO:"chaperone-mediated autophagy") |
| pubmed:30562574 | path(MESH:"Neurodegenerative Diseases") association p(HGNC:PARK7) |
| pubmed:30562574 | path(MESH:"Neurodegenerative Diseases") association p(HGNC:DPYSL2) |
| pubmed:29758300 | path(MESH:"Neurodegenerative Diseases") positiveCorrelation a(CONSO:"protein aggregates") |
| pubmed:29758300 | path(MESH:"Neurodegenerative Diseases") association bp(GO:"neuron death") |
| pubmed:22908190 | path(MESH:"Neurodegenerative Diseases") association bp(GO:"regulation of endosome size") |
| pubmed:25784053 | path(MESH:"Neurodegenerative Diseases") association path(MESH:"Protein Aggregation, Pathological") |
| pubmed:18930136 | path(MESH:"Neurodegenerative Diseases") positiveCorrelation p(MESH:Proteins, pmod(CONSO:misfolding)) |
| pubmed:29024336 | path(MESH:"Neurodegenerative Diseases") increases path(MESH:"Proteostasis Deficiencies") |
| pubmed:29024336 | path(MESH:"Neurodegenerative Diseases") increases path(MESH:"Proteostasis Deficiencies") |
| pubmed:24027553 | path(MESH:"Neurodegenerative Diseases") association p(HGNCGENEFAMILY:Calpains) |
| pubmed:23528736 | path(MESH:"Neurodegenerative Diseases") association p(HGNC:STUB1) |
| pubmed:23528736 | path(MESH:"Neurodegenerative Diseases") association p(HGNC:PRKN) |
| pubmed:23528736 | path(MESH:"Neurodegenerative Diseases") association p(HGNC:RNF182) |
| pubmed:23528736 | path(MESH:"Neurodegenerative Diseases") association p(HGNC:UCHL1, var("?")) |
| pubmed:23528736 | path(MESH:"Neurodegenerative Diseases") association p(HGNC:ATXN3, var("?")) |
| pubmed:29191965 | path(MESH:"Neurodegenerative Diseases") association bp(GO:"aggresome assembly") |
| pubmed:29311797 | path(MESH:"Neurodegenerative Diseases") association bp(MESH:Aging) |
| pubmed:29311797 | path(MESH:"Neurodegenerative Diseases") negativeCorrelation act(p(FPLX:Proteasome)) |
| pubmed:26702100 | path(MESH:"Neurodegenerative Diseases") association p(HGNC:TFEB) |
| pubmed:21543606 | bp(GO:myelination) association bp(GO:"regulation of lipid metabolic process") |
| pubmed:21543606 | bp(GO:myelination) association bp(GO:"regulation of synaptic plasticity") |
| pubmed:18680553 | bp(GO:myelination) positiveCorrelation complex(p(HGNC:FYN), p(HGNC:MAPT)) |
| pubmed:18680553 | bp(GO:myelination) association p(HGNC:MAPT) |
| pubmed:26751493 | bp(GO:myelination) association p(HGNC:FYN) |
| pubmed:26551702 | a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) |
| pubmed:26551702 | a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) |
| pubmed:26551702 | a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) |
| pubmed:22020111 | a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) |
| pubmed:22020111 | a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) |
| pubmed:22020111 | a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) |
| pubmed:22020111 | a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) |
| pubmed:26551702 | a(CHEBI:sulforaphane) decreases path(MESH:Inflammation) |
| pubmed:26551702 | a(CHEBI:sulforaphane) decreases path(MESH:Inflammation) |
| pubmed:26551702 | a(CHEBI:sulforaphane) increases bp(GO:"response to oxidative stress") |
| pubmed:26551702 | a(PUBCHEM:9958995) increases act(p(HGNC:NFE2L2)) |
| pubmed:26551702 | a(PUBCHEM:9958995) increases act(p(HGNC:NFE2L2)) |
| pubmed:26551702 | a(PUBCHEM:9958995) decreases path(MESH:Inflammation) |
| pubmed:26551702 | a(MESH:Glutathione) decreases a(CHEBI:radical) |
| pubmed:26551702 | a(MESH:Glutathione) decreases act(p(HGNC:RELA)) |
| pubmed:26551702 | a(MESH:Glutathione) decreases deg(a(MESH:"Extracellular Matrix")) |
| pubmed:26551702 | a(MESH:Glutathione) negativeCorrelation bp(GO:aging) |
| pubmed:26551702 | act(p(FPLX:HMOX)) decreases act(p(FPLX:NFkappaB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:26551702 | p(FPLX:HMOX) decreases act(p(FPLX:NFkappaB)) |
| pubmed:26551702 | act(p(FPLX:HMOX)) decreases p(HGNC:SELE) |
| pubmed:26551702 | act(p(FPLX:HMOX)) decreases p(HGNC:VCAM1) |
| pubmed:30640040 | p(HGNC:SELE) association a(PUBCHEM:9839311) |
| pubmed:30967783 | p(HGNC:VCAM1) increases a(MESH:"Leukocytes, Mononuclear", loc(MESH:"Central Nervous System")) |
| pubmed:26551702 | complex(p(HGNC:KEAP1), p(HGNC:KPNA6)) increases tloc(p(HGNC:KEAP1), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pubmed:26551702 | p(HGNC:KPNA6) decreases p(FPLX:HMOX) |
| pubmed:26551702 | p(HGNC:KPNA6) decreases p(HGNC:NQO1) |
| pubmed:26551702 | act(complex(p(HGNC:CREBBP), p(HGNC:EP300))) increases act(p(HGNC:NFE2L2)) |
| pubmed:26551702 | act(complex(p(HGNC:CREBBP), p(HGNC:EP300)), ma(GO:"histone acetyltransferase activity")) increases bp(GO:"histone acetylation") |
| pubmed:26551702 | act(complex(p(HGNC:CREBBP), p(HGNC:EP300)), ma(GO:"histone acetyltransferase activity")) increases p(HGNC:NFE2L2, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:26551702 | act(complex(p(HGNC:CREBBP), p(HGNC:EP300)), ma(GO:"histone acetyltransferase activity")) increases p(HGNC:RELA, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:25031639 | p(HGNC:CREBBP) increases p(HGNC:MAPT, frag("?"), pmod(go:0006473 ! "protein acetylation", Lys, 18)) |
| pubmed:29661268 | act(p(HGNC:CREBBP), ma(GO:"acetyltransferase activity")) increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:22530628 | p(HGNC:CREBBP) increases bp(MESH:"Neuronal Plasticity") |
| pubmed:22530628 | p(HGNC:CREBBP) increases bp(GO:cognition) |
| pubmed:30697142 | act(p(HGNC:CREBBP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases bp(GO:cognition) |
| pubmed:22530628 | p(HGNC:CREBBP) increases bp(GO:"learning or memory") |
| pubmed:22530628 | act(p(HGNC:CREBBP)) increases bp(MESH:"Cell Survival") |
| pubmed:31248781 | p(HGNC:CREBBP) regulates bp(MESH:"Cell Survival") |
| pubmed:31248781 | p(HGNC:CREBBP) association bp(MESH:"Cell Survival") |
| pubmed:22530628 | act(p(HGNC:CREBBP)) increases p(HGNC:ARC) |
| pubmed:22530628 | p(HGNC:CREBBP) increases p(HGNC:ARC) |
| pubmed:31248781 | p(HGNC:CREBBP) regulates act(a(MESH:Neurons)) |
| pubmed:31248781 | p(HGNC:CREBBP) association bp(GO:"neurotrophin signaling pathway") |
| pubmed:31248781 | p(HGNC:CREBBP) association bp(CONSO:"PI3K-Akt signaling pathway") |
| pubmed:31248781 | p(HGNC:CREBBP) association bp(MESH:Neuroprotection) |
| pubmed:31248781 | p(HGNC:CREBBP) directlyIncreases p(HGNCGENEFAMILY:Neurotrophins) |
| pubmed:31248781 | p(HGNC:CREBBP) directlyIncreases act(p(HGNCGENEFAMILY:Neurotrophins)) |
| pubmed:31248781 | p(HGNC:CREBBP) directlyIncreases p(HGNC:BDNF) |
| pubmed:31248781 | p(HGNC:CREBBP) directlyIncreases p(HGNC:NTRK2) |
| pubmed:30697142 | p(HGNC:CREBBP) decreases bp(GO:"programmed cell death") |
| pubmed:20556492 | act(p(HGNC:CREBBP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) negativeCorrelation complex(p(HGNC:CREBBP), p(HGNC:HTT, pmod(CONSO:"CAG repeats")), p(HGNC:TAF4)) |
| pubmed:14556719 | p(HGNC:CREBBP) association a(MESH:"Inclusion Bodies") |
| pubmed:26631930 | p(HGNC:CREBBP) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys)) |
| pubmed:28760828 | p(HGNC:EP300) causesNoChange p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 290)) |
| pubmed:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 290)) |
| pubmed:28760828 | act(p(HGNC:EP300)) association p(CONSO:"Tau aggregates") |
| pubmed:25031639 | p(HGNC:EP300) positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:26390242 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:29661268 | act(p(HGNC:EP300), ma(GO:"acetyltransferase activity")) increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:26631930 | p(HGNC:EP300) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys)) |
| pubmed:11691934 | p(HGNC:EP300) increases p(FPLX:"Histone_H4", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 163)) |
| pubmed:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) |
| pubmed:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 180)) |
| pubmed:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 254)) |
| pubmed:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) |
| pubmed:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281)) |
| pubmed:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 298)) |
| pubmed:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 317)) |
| pubmed:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321)) |
| pubmed:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 331)) |
| pubmed:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 352)) |
| pubmed:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 369)) |
| pubmed:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 370)) |
| pubmed:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 383)) |
| pubmed:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 385)) |
| pubmed:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 395)) |
| pubmed:26551702 | bp(GO:"histone acetylation") increases bp(GO:"chromatin disassembly") |
| pubmed:27807169 | bp(GO:"histone acetylation") increases p(RGD:Cdk5r2) |
| pubmed:26551702 | bp(GO:"chromatin disassembly") increases bp(GO:"mRNA transcription") |
| pubmed:27013968 | bp(GO:"mRNA transcription") negativeCorrelation p(HGNC:HTT, pmod(HBP:"CAG repeats")) |
| pubmed:26551702 | p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation", Ser, 276)) increases complex(p(HGNC:CREBBP), p(HGNC:NFE2L2)) |
| pubmed:26551702 | complex(p(FPLX:HDAC), p(HGNC:RELA)) increases bp(GO:"histone deacetylation") |
| pubmed:30640040 | act(p(FPLX:HDAC)) decreases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | p(FPLX:HDAC) association a(PUBCHEM:9865515) |
| pubmed:27550730 | act(p(FPLX:HDAC)) negativeCorrelation act(p(FPLX:CREB)) |
| pubmed:21427723 | act(p(FPLX:HDAC)) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:26551702 | act(p(HGNC:RAC1)) increases act(p(HGNC:NFE2L2), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:26551702 | p(HGNC:RAC1) increases p(HGNC:NFE2L2) |
| pubmed:27796283 | act(p(HGNC:RAC1)) regulates bp(GO:"dendritic spine development") |
| pubmed:26551702 | complex(p(FPLX:HSP90), p(HGNC:IKBKB)) increases deg(p(HGNC:IKBKB)) |
| pubmed:22110360 | p(FPLX:HSP90) directlyDecreases act(p(HGNC:MAP3K5)) |
| pubmed:25437566 | act(p(FPLX:HSP90)) association a(CHEBI:ATP) |
| pubmed:25437566 | p(FPLX:HSP90) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:25437566 | p(FPLX:HSP90) increases bp(GO:"protein folding") |
| pubmed:23746257 | act(p(FPLX:HSP90)) increases bp(GO:"protein folding") |
| pubmed:25784053 | p(FPLX:HSP90) regulates bp(GO:"protein folding") |
| pubmed:27491084 | p(FPLX:HSP90) association bp(CONSO:Proteostasis) |
| pubmed:29311797 | p(FPLX:HSP90) association bp(CONSO:Proteostasis) |
| pubmed:23746257 | act(p(FPLX:HSP90)) association bp(GO:"'de novo' protein folding") |
| pubmed:23746257 | act(p(FPLX:HSP90)) association bp(GO:"protein refolding") |
| pubmed:23746257 | p(FPLX:HSP90) association bp(GO:"cell cycle") |
| pubmed:23746257 | p(FPLX:HSP90) association bp(GO:"steroid hormone mediated signaling pathway") |
| pubmed:23746257 | p(FPLX:HSP90) association bp(GO:"calcium-mediated signaling") |
| pubmed:23746257 | p(FPLX:HSP90) association bp(GO:"protein transport") |
| pubmed:23746257 | p(FPLX:HSP90) association bp(GO:"protein secretion") |
| pubmed:23746257 | p(FPLX:HSP90) association bp(GO:"immune response") |
| pubmed:23746257 | p(FPLX:HSP90) association bp(MESH:"Heat-Shock Response") |
| pubmed:25784053 | p(FPLX:HSP90) isA a(MESH:"Molecular Chaperones") |
| pubmed:25784053 | p(FPLX:HSP90) regulates bp(MESH:Proteolysis) |
| pubmed:25784053 | act(p(FPLX:HSP90)) decreases act(p(HGNC:HSF1)) |
| pubmed:24563850 | p(FPLX:HSP90) decreases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:29311797 | p(FPLX:HSP90) regulates path(MESH:"Protein Aggregation, Pathological") |
| pubmed:21882945 | act(p(FPLX:HSP90)) association a(CHEBI:celastrol) |
| pubmed:21882945 | p(FPLX:HSP90) increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") |
| pubmed:21882945 | p(FPLX:HSP90) increases bp(GO:"proteasomal protein catabolic process") |
| pubmed:21882945 | p(FPLX:HSP90) increases bp(GO:autophagy) |
| pubmed:21882945 | p(FPLX:HSP90) increases act(p(HGNC:STUB1)) |
| pubmed:21882945 | p(FPLX:HSP90) increases bp(GO:"protein catabolic process") |
| pubmed:21882945 | p(FPLX:HSP90) increases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:21882945 | p(FPLX:HSP90) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21882945 | p(FPLX:HSP90) regulates p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19363271 | p(FPLX:HSP90) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21882945 | p(FPLX:HSP90) regulates act(p(HGNC:GSK3B)) |
| pubmed:21882945 | p(FPLX:HSP90) regulates p(HGNC:MAPT, var("?")) |
| pubmed:29311797 | p(FPLX:HSP90) increases p(HGNC:MAPT, var("?")) |
| pubmed:19363271 | p(FPLX:HSP90) increases complex(p(FPLX:HSP90), p(HGNC:MAPT)) |
| pubmed:25374103 | p(FPLX:HSP90) increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) |
| pubmed:29311797 | p(FPLX:HSP90) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:25374103 | p(FPLX:HSP90) increases deg(p(HGNC:MAPT, pmod(CONSO:misfolded))) |
| pubmed:29311797 | p(FPLX:HSP90) regulates a(CONSO:"Tau aggregates") |
| pubmed:29311797 | p(FPLX:HSP90) increases act(p(FPLX:Proteasome)) |
| pubmed:29311797 | p(FPLX:HSP90) association bp(GO:"chaperone-mediated autophagy") |
| pubmed:29311797 | act(p(FPLX:HSP90), ma(GO:"ATPase activity")) increases path(MESH:Tauopathies) |
| pubmed:19363271 | p(FPLX:HSP90) association p(CONSO:"VQIVYK motif") |
| pubmed:19363271 | p(FPLX:HSP90) positiveCorrelation bp(GO:"neurofibrillary tangle assembly") |
| pubmed:20133804 | p(FPLX:HSP90) association p(HGNC:FKBP4, frag("270_386")) |
| pubmed:21367866 | act(p(FPLX:HSP90)) positiveCorrelation p(HGNC:CDC37) |
| pubmed:26551702 | complex(p(HGNC:IKBKB), p(HGNC:KEAP1)) increases p(HGNC:NFKBIA) |
| pubmed:26551702 | complex(p(HGNC:IKBKB), p(HGNC:KEAP1)) decreases act(p(FPLX:NFkappaB)) |
| pubmed:26551702 | p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) increases complex(p(HGNC:BTRC), p(HGNC:NFE2L2)) |
| pubmed:21722302 | p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) increases r(HGNCGENEFAMILY:"Soluble glutathione S-transferases") |
| pubmed:21722302 | p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) increases r(HGNCGENEFAMILY:"NADH:ubiquinone oxidoreductase core subunits") |
| pubmed:21722302 | p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) increases r(MESH:"Heme Oxygenase-1") |
| pubmed:21722302 | p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) increases r(MESH:Glucuronosyltransferase) |
| pubmed:21722302 | p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) increases r(MESH:"Glutamate-Cysteine Ligase") |
| pubmed:29121589 | p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) partOf complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:26551702 | p(HGNC:SQSTM1) regulates bp(GO:"inflammatory response") |
| pubmed:26551702 | p(HGNC:SQSTM1) regulates bp(GO:"response to oxidative stress") |
| pubmed:26551702 | p(HGNC:SQSTM1) increases act(p(HGNC:NFE2L2)) |
| pubmed:26551702 | p(HGNC:SQSTM1) increases deg(p(HGNC:KEAP1)) |
| pubmed:26551702 | p(HGNC:SQSTM1) increases p(HGNC:TRAF6, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:26551702 | p(HGNC:SQSTM1) increases act(p(HGNC:TRAF6)) |
| pubmed:22020111 | p(HGNC:SQSTM1) increases bp(GO:autophagy) |
| pubmed:22908190 | p(HGNC:SQSTM1) increases bp(GO:autophagy) |
| pubmed:18930136 | p(HGNC:SQSTM1) regulates bp(GO:autophagy) |
| pubmed:18930136 | p(HGNC:SQSTM1) increases bp(GO:autophagy) |
| pubmed:18930136 | p(HGNC:SQSTM1) increases bp(GO:autophagy) |
| pubmed:22020111 | p(HGNC:SQSTM1) decreases bp(GO:"stress-induced premature senescence") |
| pubmed:29758300 | p(HGNC:SQSTM1) increases deg(p(HGNC:MAPT)) |
| pubmed:29758300 | p(HGNC:SQSTM1) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:29758300 | p(HGNC:SQSTM1) increases p(HGNC:SYP) |
| pubmed:29758300 | p(HGNC:SQSTM1) regulates bp(GO:"short-term memory") |
| pubmed:22908190 | p(HGNC:SQSTM1) association bp(GO:"proteasomal protein catabolic process") |
| pubmed:18930136 | p(HGNC:SQSTM1) regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:18930136 | p(HGNC:SQSTM1) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:18930136 | p(HGNC:SQSTM1) regulates a(GO:aggresome) |
| pubmed:18930136 | p(HGNC:SQSTM1) association a(GO:"Lewy body") |
| pubmed:18930136 | p(HGNC:SQSTM1) association a(GO:"neurofibrillary tangle") |
| pubmed:18930136 | p(HGNC:SQSTM1) association a(MESH:"Huntingtin Protein") |
| pubmed:18930136 | p(HGNC:SQSTM1) association p(HGNC:SOD1, var("?")) |
| pubmed:18930136 | p(HGNC:SQSTM1) increases deg(p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"))) |
| pubmed:18930136 | p(HGNC:SQSTM1) increases bp(GO:"ubiquitin-dependent protein catabolic process") |
| pubmed:30116051 | p(HGNC:SQSTM1) association path(MESH:"Frontotemporal Dementia") |
| pubmed:30116051 | p(HGNC:SQSTM1) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:SQSTM1, loc(GO:"inclusion body")) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:SQSTM1, loc(GO:"inclusion body")) association path(MESH:Autophagy) |
| pubmed:30837838 | p(HGNC:SQSTM1, loc(GO:"inclusion body")) association path(MESH:"Frontotemporal Lobar Degeneration") |
| pubmed:26551702 | complex(p(HGNC:MAFK), p(HGNC:NFE2L2)) regulates act(p(HGNC:RELA), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:26551702 | p(HGNC:MAFK) increases complex(p(HGNC:CREBBP), p(HGNC:RELA)) |
| pubmed:26551702 | p(HGNC:MAFK) increases a(MESH:Cytokines) |
| pubmed:26551702 | complex(p(HGNC:CREBBP), p(HGNC:RELA)) increases p(HGNC:RELA) |
| pubmed:26551702 | a(CHEBI:cinnamate) decreases path(MESH:Inflammation) |
| pubmed:26551702 | a(CHEBI:cinnamate) increases act(p(HGNC:NFE2L2)) |
| pubmed:26551702 | a(CHEBI:cinnamate) increases bp(GO:"response to oxidative stress") |
| pubmed:30962309 | path(MESH:Infection) increases complex(MESH:Inflammasomes) |
| pubmed:26445701 | path(MESH:Infection) decreases path(MESH:"Autoimmune Diseases") |
| pubmed:26445701 | path(MESH:Infection) decreases path(HP:Allergy) |
| pubmed:19126755 | path(MESH:Infection) association path(MESH:"Tobacco Use Disorder") |
| pubmed:30988501 | path(MESH:Infection) increases path(MESH:"Illness Behavior") |
| pubmed:30988501 | path(MESH:Infection) decreases bp(GO:cognition) |
| pubmed:30988501 | path(MESH:Infection) decreases bp(GO:cognition) |
| pubmed:30988501 | path(MESH:Infection) decreases bp(GO:cognition) |
| pubmed:30988501 | path(MESH:Infection) increases path(MESH:"Signs and Symptoms") |
| pubmed:30988501 | path(MESH:Infection) increases path(MESH:Inflammation) |
| pubmed:30988501 | path(MESH:Infection) increases path(DOID:"learning disability") |
| pubmed:30988501 | path(MESH:Infection) decreases bp(GO:"learning or memory") |
| pubmed:30988501 | path(MESH:Infection) decreases path(MESH:Attention) |
| pubmed:30988501 | path(MESH:Infection) increases path(DOID:"autism spectrum disorder") |
| pubmed:30988501 | path(MESH:Infection) increases path(MESH:Recurrence) |
| pubmed:30962309 | complex(MESH:Inflammasomes) increases deg(p(HGNC:IL1B)) |
| pubmed:30962309 | complex(MESH:Inflammasomes) increases deg(p(HGNC:IL18)) |
| pubmed:30962309 | act(complex(MESH:Inflammasomes)) association path(DOID:cancer) |
| pubmed:30962309 | act(complex(MESH:Inflammasomes)) association path(DOID:"multiple sclerosis") |
| pubmed:30962309 | act(complex(MESH:Inflammasomes)) association path(DOID:"rheumatic disease") |
| pubmed:30962309 | complex(MESH:Inflammasomes) regulates path(MESH:Microbiota) |
| pubmed:30962309 | complex(MESH:Inflammasomes) decreases path(MESH:"Host-Pathogen Interactions") |
| pubmed:30962309 | complex(MESH:Inflammasomes) decreases path(DOID:"inflammatory bowel disease") |
| pubmed:30988501 | act(complex(MESH:Inflammasomes)) increases a(MESH:"Inflammation Mediators") |
| pubmed:30962309 | path(NCIT:C50773) increases complex(MESH:Inflammasomes) |
| pubmed:30962309 | path(MESH:Metabolome) increases complex(MESH:Inflammasomes) |
| pubmed:30962309 | g(HGNC:NLRP3) increases complex(MESH:Inflammasomes) |
| pubmed:24561250 | g(HGNC:NLRP3) increases a(CHEBI:amyloid-beta) |
| pubmed:24561250 | g(HGNC:NLRP3) decreases bp(GO:memory) |
| pubmed:24561250 | g(HGNC:NLRP3) decreases bp(GO:behavior) |
| pubmed:30962309 | g(HGNC:MEFV) increases complex(MESH:Inflammasomes) |
| pubmed:30962309 | p(HGNC:NLRP3, var("?")) increases path(NCIT:C84657) |
| pubmed:30962309 | p(HGNC:NLRP3, var("?")) increases path(DOID:"familial Mediterranean fever") |
| pubmed:30962309 | p(HGNC:NLRP3) increases act(p(HGNC:IL1B)) |
| pubmed:30962309 | p(HGNC:NLRP3) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30962309 | p(HGNC:NLRP3) increases act(p(HGNC:IL18)) |
| pubmed:30962309 | p(HGNC:NLRP3) increases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30962309 | p(HGNC:NLRP3) association m(MIRBASE:hsa-mir-223) |
| pubmed:30962309 | p(HGNC:NLRP3) positiveCorrelation bp(GO:"monocyte differentiation") |
| pubmed:30962309 | p(HGNC:NLRP3) directlyIncreases bp(GO:"evasion or tolerance of host defenses by virus") |
| pubmed:27314526 | p(HGNC:NLRP3) association a(CHEBI:amyloid-beta) |
| pubmed:27314526 | act(p(HGNC:NLRP3)) increases tloc(p(HGNC:CASP1), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30962309 | path(NCIT:C84657) directlyIncreases bp(GO:"activation of innate immune response") |
| pubmed:30962309 | path(NCIT:C84657) isA path(NCIT:C119050) |
| pubmed:30962309 | p(HGNC:MEFV, var("?")) increases path(NCIT:C84657) |
| pubmed:30962309 | p(HGNC:MEFV, var("?")) increases path(DOID:"familial Mediterranean fever") |
| pubmed:30962309 | p(HGNC:MEFV) increases act(p(HGNC:IL1B)) |
| pubmed:30962309 | p(HGNC:MEFV) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30962309 | p(HGNC:MEFV) increases act(p(HGNC:IL18)) |
| pubmed:30962309 | p(HGNC:MEFV) increases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30962309 | path(DOID:"familial Mediterranean fever") directlyIncreases bp(GO:"activation of innate immune response") |
| pubmed:30962309 | path(DOID:"familial Mediterranean fever") isA path(NCIT:C119050) |
| pubmed:27794524 | bp(GO:"activation of innate immune response") directlyIncreases tloc(a(CHEBI:"reactive oxygen species"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27794524 | bp(GO:"activation of innate immune response") directlyIncreases tloc(a(CHEBI:"reactive nitrogen species"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27794524 | bp(GO:"activation of innate immune response") directlyIncreases tloc(a(CHEBI:"nitric oxide"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30962309 | path(DOID:cancer) association act(complex(MESH:Inflammasomes)) |
| pubmed:30962309 | path(DOID:cancer) association p(HGNC:IL1B) |
| pubmed:30962309 | path(DOID:cancer) association p(HGNC:IL18) |
| pubmed:25546293 | path(DOID:cancer) increases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) |
| pubmed:30962309 | path(DOID:"multiple sclerosis") association act(complex(MESH:Inflammasomes)) |
| pubmed:30962309 | path(DOID:"multiple sclerosis") association p(HGNC:IL1B) |
| pubmed:30962309 | path(DOID:"multiple sclerosis") association p(HGNC:IL18) |
| pubmed:30962309 | path(DOID:"multiple sclerosis") association path(MESH:Autoimmunity) |
| pubmed:30962309 | path(DOID:"multiple sclerosis") negativeCorrelation m(MIRBASE:hsa-mir-146a) |
| pubmed:30962309 | path(DOID:"multiple sclerosis") negativeCorrelation m(MIRBASE:hsa-mir-155) |
| pubmed:30962309 | path(DOID:"multiple sclerosis") directlyIncreases m(MIRBASE:hsa-mir-155) |
| pubmed:30962309 | path(DOID:"multiple sclerosis") negativeCorrelation m(MIRBASE:hsa-mir-223) |
| pubmed:30962309 | path(DOID:"multiple sclerosis") directlyIncreases m(MIRBASE:hsa-mir-22, loc(MESH:Plasma)) |
| pubmed:27889190 | path(DOID:"multiple sclerosis") association bp(MESH:Sensation) |
| pubmed:27889190 | path(DOID:"multiple sclerosis") association path(MESH:"Mobility Limitation") |
| pubmed:27889190 | path(DOID:"multiple sclerosis") association bp(MESH:"Postural Balance") |
| pubmed:27889190 | path(DOID:"multiple sclerosis") association a(NCIT:C28381) |
| pubmed:27889190 | path(DOID:"multiple sclerosis") association bp(MESH:"Vision, Ocular") |
| pubmed:27889190 | path(DOID:"multiple sclerosis") association bp(GO:cognition) |
| pubmed:30988501 | path(DOID:"multiple sclerosis") decreases bp(GO:cognition) |
| pubmed:30988501 | path(DOID:"multiple sclerosis") decreases bp(GO:cognition) |
| pubmed:27889190 | path(DOID:"multiple sclerosis") increases bp(MESH:"Lymphocyte Count") |
| pubmed:27889190 | path(DOID:"multiple sclerosis") increases p(MESH:Proteins) |
| pubmed:27889190 | path(DOID:"multiple sclerosis") increases p(MESH:"Immunoglobulin G") |
| pubmed:27889190 | path(DOID:"multiple sclerosis") positiveCorrelation path(MESH:"Spinal Cord Injuries") |
| pubmed:27889190 | path(DOID:"multiple sclerosis") increases path(HP:"CNS demyelination") |
| pubmed:26445701 | path(DOID:"multiple sclerosis") increases path(HP:"CNS demyelination") |
| pubmed:27889190 | path(DOID:"multiple sclerosis") increases path(HP:"CNS demyelination") |
| pubmed:30988501 | path(DOID:"multiple sclerosis") increases path(HP:"CNS demyelination") |
| pubmed:27889190 | path(DOID:"multiple sclerosis") increases path(HP:Encephalopathy) |
| pubmed:27889190 | path(DOID:"multiple sclerosis") increases path(MESH:"Neurologic Manifestations") |
| pubmed:27889190 | path(DOID:"multiple sclerosis") increases path(HP:Seizures) |
| pubmed:27889190 | path(DOID:"multiple sclerosis") association path(MESH:"Central Nervous System Diseases") |
| pubmed:27889190 | path(DOID:"multiple sclerosis") association path(DOID:"leukoencephalopathy with vanishing white matter") |
| pubmed:27889190 | path(DOID:"multiple sclerosis") association path(MESH:"Vasculopathy, Retinal, With Cerebral Leukodystrophy") |
| pubmed:27889190 | path(DOID:"multiple sclerosis") association path(MESH:"Brain Diseases, Metabolic") |
| pubmed:27889190 | path(DOID:"multiple sclerosis") association path(DOID:neurosarcoidosis) |
| pubmed:27889190 | path(DOID:"multiple sclerosis") association path(DOID:"central nervous system vasculitis") |
| pubmed:27889190 | path(DOID:"multiple sclerosis") association path(DOID:"Behcet's disease") |
| pubmed:28843454 | path(DOID:"multiple sclerosis") association path(MESH:"Life Style") |
| pubmed:28843454 | path(DOID:"multiple sclerosis") association path(MESH:Environment) |
| pubmed:28843454 | path(DOID:"multiple sclerosis") positiveCorrelation path(NCIT:C68642) |
| pubmed:28843454 | path(DOID:"multiple sclerosis") association path(MESH:Sunlight) |
| pubmed:28843454 | path(DOID:"multiple sclerosis") association bp(GO:"response to light intensity") |
| pubmed:28843454 | path(DOID:"multiple sclerosis") association a(CHEBI:"24,25-Dihydroxyvitamin D") |
| pubmed:28843454 | path(DOID:"multiple sclerosis") negativeCorrelation a(MESH:"Vitamin D") |
| pubmed:28843454 | path(DOID:"multiple sclerosis") increases path(MESH:"Epstein-Barr Virus Infections") |
| pubmed:26445701 | path(DOID:"multiple sclerosis") positiveCorrelation path(MESH:"Epstein-Barr Virus Infections") |
| pubmed:28843454 | path(DOID:"multiple sclerosis") association path(EFO:"human herpesvirus 6 seropositivity") |
| pubmed:28843454 | path(DOID:"multiple sclerosis") increases p(MESH:Antibodies) |
| pubmed:28843454 | path(DOID:"multiple sclerosis") positiveCorrelation g(IMGTHLA:HLA00865) |
| pubmed:28843454 | path(DOID:"multiple sclerosis") association a(MESH:"DNA, Mitochondrial") |
| pubmed:28843454 | path(DOID:"multiple sclerosis") association p(HGNC:HLA-DRB1) |
| pubmed:28843454 | path(DOID:"multiple sclerosis") association path(EFO:"developmental disability") |
| pubmed:28843454 | path(DOID:"multiple sclerosis") association path(DOID:"mental depression") |
| pubmed:28843454 | path(DOID:"multiple sclerosis") association path(MESH:Fatigue) |
| pubmed:28843454 | path(DOID:"multiple sclerosis") decreases path(MESH:Exercise) |
| pubmed:28843454 | path(DOID:"multiple sclerosis") association path(DOID:"cognitive disorder") |
| pubmed:30988501 | path(DOID:"multiple sclerosis") increases path(NCIT:C21007) |
| pubmed:30988501 | path(DOID:"multiple sclerosis") decreases path(MESH:"Life Expectancy") |
| pubmed:30988501 | path(DOID:"multiple sclerosis") increases path(HP:"Axonal loss") |
| pubmed:26445701 | path(DOID:"multiple sclerosis") increases path(HP:"Axonal loss") |
| pubmed:26445701 | path(DOID:"multiple sclerosis") increases path(HP:"Axonal loss") |
| pubmed:26445701 | path(DOID:"multiple sclerosis") isA path(DOID:"autoimmune disease of central nervous system") |
| pubmed:26445701 | path(DOID:"multiple sclerosis") increases path(MESH:Inflammation) |
| pubmed:26445701 | path(DOID:"multiple sclerosis") increases path(MESH:Inflammation) |
| pubmed:26445701 | path(DOID:"multiple sclerosis") positiveCorrelation g(HGNCGENEFAMILY:"Histocompatibility complex") |
| pubmed:26445701 | path(DOID:"multiple sclerosis") positiveCorrelation g(HGNC:IL2RA) |
| pubmed:26445701 | path(DOID:"multiple sclerosis") positiveCorrelation g(HGNC:IL7R) |
| pubmed:26445701 | path(DOID:"multiple sclerosis") positiveCorrelation path(MESH:"Vitamin D Deficiency") |
| pubmed:26445701 | path(DOID:"multiple sclerosis") increases deg(a(GO:"myelin sheath")) |
| pubmed:26445701 | path(DOID:"multiple sclerosis") association a(MESH:B-Lymphocytes) |
| pubmed:26445701 | path(DOID:"multiple sclerosis") increases path(MESH:"Diffuse Axonal Injury") |
| pubmed:26445701 | path(DOID:"multiple sclerosis") increases a(HP:"Focal white matter lesions") |
| pubmed:26445701 | path(DOID:"multiple sclerosis") association bp(GO:"sensory perception") |
| pubmed:26445701 | path(DOID:"multiple sclerosis") association bp(GO:"motor behavior") |
| pubmed:26445701 | path(DOID:"multiple sclerosis") association bp(GO:"visual behavior") |
| pubmed:26445701 | path(DOID:"multiple sclerosis") increases path(HP:Fatigue) |
| pubmed:26445701 | path(DOID:"multiple sclerosis") increases path(HP:Spasticity) |
| pubmed:26445701 | path(DOID:"multiple sclerosis") increases path(HP:"Gallbladder dysfunction") |
| pubmed:26445701 | path(DOID:"multiple sclerosis") increases path(DOID:"pain disorder") |
| pubmed:27889190 | path(DOID:"multiple sclerosis") increases bp(GO:"B cell activation") |
| pubmed:27889190 | path(DOID:"multiple sclerosis") increases bp(GO:"T cell activation") |
| pubmed:27889190 | path(DOID:"multiple sclerosis") increases deg(a(MESH:"Blood-Brain Barrier")) |
| pubmed:27889190 | path(DOID:"multiple sclerosis") association bp(MESH:"Axonal Transport") |
| pubmed:30967783 | path(DOID:"multiple sclerosis") association path(CONSO:"mitochondrial dysfunction") |
| pubmed:30967783 | path(DOID:"multiple sclerosis") increases a(MESH:Macrophages) |
| pubmed:30967783 | path(DOID:"multiple sclerosis") association a(MESH:"Leukocytes, Mononuclear") |
| pubmed:30967783 | path(DOID:"multiple sclerosis") increases p(HGNC:CXCL9) |
| pubmed:30967783 | path(DOID:"multiple sclerosis") increases p(HGNC:CXCL10) |
| pubmed:30967783 | path(DOID:"multiple sclerosis") increases r(HGNC:GAS5, loc(MESH:Microglia)) |
| pubmed:26979166 | path(DOID:"multiple sclerosis") increases path(MESH:Depression) |
| pubmed:26979166 | path(DOID:"multiple sclerosis") increases bp(GO:"lymphocyte activation") |
| pubmed:26979166 | path(DOID:"multiple sclerosis") increases bp(GO:"macrophage activation") |
| pubmed:26979166 | path(DOID:"multiple sclerosis") increases act(a(MESH:"Dendritic Cells")) |
| pubmed:26979166 | path(DOID:"multiple sclerosis") increases bp(GO:"microglial cell activation") |
| pubmed:30988501 | path(DOID:"multiple sclerosis") isA path(DOID:encephalomyelitis) |
| pubmed:30988501 | path(DOID:"multiple sclerosis") isA path(MESH:"Autoimmune Diseases") |
| pubmed:30988501 | path(DOID:"multiple sclerosis") increases path(CONSO:Neurodegeneration) |
| pubmed:30988501 | path(DOID:"multiple sclerosis") decreases bp(GO:"learning or memory") |
| pubmed:30988501 | path(DOID:"multiple sclerosis") increases path(DOID:"secondary progressive multiple sclerosis") |
| pubmed:30988501 | path(DOID:"multiple sclerosis") increases deg(a(MESH:"Cerebral Cortex")) |
| pubmed:30988501 | path(DOID:"multiple sclerosis") decreases a(MESH:"T-Lymphocytes, Regulatory") |
| pubmed:30988501 | path(DOID:"multiple sclerosis") decreases a(MESH:"B-Lymphocytes, Regulatory") |
| pubmed:30988501 | path(DOID:"multiple sclerosis") increases deg(a(MESH:"Gray Matter")) |
| pubmed:30988501 | path(DOID:"multiple sclerosis") positiveCorrelation path(MESH:"Psychosocial Deprivation") |
| pubmed:30962309 | path(DOID:"rheumatic disease") association act(complex(MESH:Inflammasomes)) |
| pubmed:30962309 | path(DOID:"rheumatic disease") association p(HGNC:IL1B) |
| pubmed:30962309 | path(DOID:"rheumatic disease") association p(HGNC:IL18) |
| pubmed:30962309 | path(DOID:"rheumatic disease") association path(MESH:Autoimmunity) |
| pubmed:30962309 | path(MESH:Autoimmunity) association path(DOID:"rheumatic disease") |
| pubmed:30962309 | path(MESH:Autoimmunity) association path(DOID:"multiple sclerosis") |
| pubmed:27794524 | path(MESH:Autoimmunity) association path(MESH:"Multiple Sclerosis") |
| pubmed:27794524 | path(MESH:Autoimmunity) causesNoChange path(MESH:"Tertiary Lymphoid Structures") |
| pubmed:30962309 | r(MESH:MicroRNAs) regulates complex(MESH:Inflammasomes) |
| pubmed:30962309 | p(HGNC:NLRP1) increases act(p(HGNC:IL1B)) |
| pubmed:30962309 | p(HGNC:NLRP1) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:24561250 | p(HGNC:NLRP1) increases p(HGNC:IL1B) |
| pubmed:30962309 | p(HGNC:NLRP1) increases act(p(HGNC:IL18)) |
| pubmed:30962309 | p(HGNC:NLRP1) increases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:24561250 | p(HGNC:NLRP1) increases p(HGNC:IL18) |
| pubmed:30962309 | p(HGNC:NLRC4) increases act(p(HGNC:IL1B)) |
| pubmed:30962309 | p(HGNC:NLRC4) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30962309 | p(HGNC:NLRC4) increases act(p(HGNC:IL18)) |
| pubmed:30962309 | p(HGNC:NLRC4) increases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:23702978 | act(p(HGNC:NLRC4)) increases complex(p(HGNC:CFL1), p(HGNC:SCAF11)) |
| pubmed:24561250 | p(HGNC:NLRC4) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:30962309 | p(HGNC:AIM2) increases act(p(HGNC:IL1B)) |
| pubmed:30962309 | p(HGNC:AIM2) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30962309 | p(HGNC:AIM2) increases act(p(HGNC:IL18)) |
| pubmed:30962309 | p(HGNC:AIM2) increases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30962309 | p(HGNC:CASP4) increases path(MESH:Pyroptosis) |
| pubmed:30962309 | p(HGNC:CASP4) increases bp(GO:"NLRP3 inflammasome complex assembly") |
| pubmed:30962309 | p(HGNC:CASP5) increases path(MESH:Pyroptosis) |
| pubmed:30962309 | p(HGNC:CASP5) increases bp(GO:"NLRP3 inflammasome complex assembly") |
| pubmed:30962309 | p(HGNC:CASP8) increases path(MESH:Pyroptosis) |
| pubmed:30962309 | p(HGNC:CASP8) increases bp(GO:"NLRP3 inflammasome complex assembly") |
| pubmed:30962309 | p(HGNC:CASP8, loc(GO:"inflammasome complex")) association m(MIRBASE:hsa-mir-371a) |
| pubmed:30962309 | p(HGNC:CASP8, loc(GO:"inflammasome complex")) association m(MIRBASE:hsa-mir-373) |
| pubmed:30962309 | p(HGNC:CASP8, loc(GO:"inflammasome complex")) association m(MIRBASE:hsa-mir-543) |
| pubmed:30962309 | p(HGNC:CASP8, loc(GO:"inflammasome complex")) increases p(HGNC:TNF) |
| pubmed:23516100 | act(p(HGNC:CASP8)) increases complex(p(HGNC:CASP8), p(HGNC:MAPT, frag("1_421"))) |
| pubmed:23516100 | p(HGNC:CASP8) increases p(HGNC:MAPT, frag("?")) |
| pubmed:23516100 | p(HGNC:CASP8) increases p(HGNC:MAPT, frag("421_*"), var("?")) |
| pubmed:23702978 | p(HGNC:CASP8) increases act(p(HGNC:IL1B)) |
| pubmed:23702978 | act(p(HGNC:CASP8)) increases act(p(HGNC:IL1B)) |
| pubmed:23702978 | act(p(HGNC:CASP8)) regulates act(p(HGNC:IL1B)) |
| pubmed:23702978 | act(p(HGNC:CASP8)) regulates act(p(HGNC:IL18)) |
| pubmed:30962309 | a(PUBCHEM:223370366) decreases path(DOID:"multiple sclerosis") |
| pubmed:30962309 | a(PUBCHEM:223370366) regulates complex(MESH:Inflammasomes) |
| pubmed:30962309 | a(PUBCHEM:223370366) regulates m(MIRBASE:hsa-mir-20a) |
| pubmed:30962309 | a(PUBCHEM:223370366) regulates m(MIRBASE:hsa-mir-30a) |
| pubmed:30962309 | a(PUBCHEM:223370366) regulates m(MIRBASE:hsa-mir-146a) |
| pubmed:30962309 | a(PUBCHEM:223370366) association p(HGNC:IFNAR1) |
| pubmed:27794524 | a(PUBCHEM:223370366) decreases path(MESH:"Developmental Disabilities") |
| pubmed:27794524 | a(PUBCHEM:223370366) directlyDecreases path(MESH:"Multiple Sclerosis, Relapsing-Remitting") |
| pubmed:27794524 | a(PUBCHEM:223370366) increases p(MESH:Serum) |
| pubmed:27794524 | a(PUBCHEM:223370366) increases p(HGNC:BDNF) |
| pubmed:27956442 | a(PUBCHEM:223370366) decreases path(MESH:"Demyelinating Diseases") |
| pubmed:27956442 | a(PUBCHEM:223370366) causesNoChange path(MESH:"Multiple Sclerosis, Chronic Progressive") |
| pubmed:30962309 | a(PUBCHEM:3081884) decreases path(DOID:"multiple sclerosis") |
| pubmed:30962309 | a(PUBCHEM:3081884) regulates complex(MESH:Inflammasomes) |
| pubmed:30962309 | a(PUBCHEM:3081884) decreases m(MIRBASE:hsa-mir-146a) |
| pubmed:27794524 | a(PUBCHEM:3081884) increases p(MESH:Serum) |
| pubmed:27794524 | a(PUBCHEM:3081884) increases p(HGNC:BDNF) |
| pubmed:27956442 | a(PUBCHEM:3081884) decreases path(MESH:"Demyelinating Diseases") |
| pubmed:30962309 | a(PUBCHEM:53787563) decreases path(DOID:"systemic lupus erythematosus") |
| pubmed:30962309 | a(PUBCHEM:53787563) regulates complex(MESH:Inflammasomes) |
| pubmed:30962309 | path(DOID:"systemic lupus erythematosus") negativeCorrelation m(MIRBASE:hsa-mir-146a) |
| pubmed:30962309 | path(DOID:"systemic lupus erythematosus") directlyIncreases m(MIRBASE:hsa-mir-146a) |
| pubmed:30962309 | path(DOID:"systemic lupus erythematosus") negativeCorrelation m(MIRBASE:hsa-mir-155) |
| pubmed:30962309 | path(DOID:"systemic lupus erythematosus") directlyDecreases m(MIRBASE:hsa-mir-155, loc(MESH:"Peripheral Blood Stem Cells")) |
| pubmed:30962309 | path(DOID:"systemic lupus erythematosus") directlyIncreases m(MIRBASE:hsa-mir-155, loc(MESH:Urine)) |
| pubmed:30962309 | path(DOID:"systemic lupus erythematosus") negativeCorrelation m(MIRBASE:hsa-mir-223) |
| pubmed:30962309 | path(DOID:"systemic lupus erythematosus") directlyDecreases m(MIRBASE:hsa-mir-223, loc(MESH:B-Lymphocytes)) |
| pubmed:30962309 | path(DOID:"systemic lupus erythematosus") association g(DBSNP:rs57095329) |
| pubmed:30962309 | path(DOID:"systemic lupus erythematosus") association g(DBSNP:rs2431697) |
| pubmed:30962309 | path(DOID:"systemic lupus erythematosus") directlyDecreases m(MIRBASE:hsa-mir-20a, loc(MESH:Monocytes)) |
| pubmed:30962309 | path(DOID:"systemic lupus erythematosus") directlyDecreases m(MIRBASE:hsa-mir-17, loc(MESH:"Peripheral Blood Stem Cells")) |
| pubmed:27889190 | path(DOID:"systemic lupus erythematosus") increases path(DOID:"optic neuritis") |
| pubmed:27889190 | path(DOID:"systemic lupus erythematosus") increases path(DOID:myelitis) |
| pubmed:27889190 | path(DOID:"systemic lupus erythematosus") increases path(MESH:"Abortion, Habitual") |
| pubmed:30988501 | path(DOID:"systemic lupus erythematosus") increases complex(a(MESH:Autoantibodies), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pubmed:30962309 | a(PUBCHEM:135305802) decreases path(DOID:"rheumatic disease") |
| pubmed:30962309 | a(PUBCHEM:135305802) directlyDecreases p(HGNC:TNF) |
| pubmed:30988501 | a(PUBCHEM:135305802) decreases p(HGNC:TNF) |
| pubmed:30962309 | a(PUBCHEM:135305802) regulates complex(MESH:Inflammasomes) |
| pubmed:30988501 | a(PUBCHEM:135305802) negativeCorrelation path(DOID:"mental depression") |
| pubmed:30962309 | act(complex(GO:"NLRP3 inflammasome complex")) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30962309 | complex(GO:"NLRP3 inflammasome complex") increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28019679 | act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL1B) |
| pubmed:28019679 | act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL1B) |
| pubmed:24561250 | complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:IL1B) |
| pubmed:24561250 | complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:IL1B) |
| pubmed:30962309 | act(complex(GO:"NLRP3 inflammasome complex")) increases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28019679 | act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL18) |
| pubmed:30962309 | act(complex(GO:"NLRP3 inflammasome complex")) increases path(DOID:"neurodegenerative disease") |
| pubmed:30962309 | act(complex(GO:"NLRP3 inflammasome complex")) negativeCorrelation path(MESH:Neuralgia) |
| pubmed:28019679 | complex(GO:"NLRP3 inflammasome complex") increases act(p(HGNC:CASP1)) |
| pubmed:28019679 | act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:CASP1) |
| pubmed:27314526 | complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:CASP1) |
| pubmed:28019679 | complex(GO:"NLRP3 inflammasome complex") increases a(CHEBI:"nitric oxide") |
| pubmed:28019679 | complex(GO:"NLRP3 inflammasome complex") increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28019679 | act(complex(GO:"NLRP3 inflammasome complex")) decreases path(MESH:"Spatial Memory") |
| pubmed:28019679 | act(complex(GO:"NLRP3 inflammasome complex")) increases a(CHEBI:amyloid-beta) |
| pubmed:24561250 | complex(GO:"NLRP3 inflammasome complex") association path(MESH:"Alzheimer Disease") |
| pubmed:24561250 | complex(GO:"NLRP3 inflammasome complex") increases path(MESH:"Plaque, Amyloid") |
| pubmed:23702978 | p(HGNC:PYCARD) increases complex(p(HGNC:CASP1), p(HGNC:CASP1)) |
| pubmed:24561250 | p(HGNC:PYCARD) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pubmed:24561250 | p(HGNC:PYCARD) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pubmed:24561250 | p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) |
| pubmed:24561250 | p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) |
| pubmed:24561250 | p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) |
| pubmed:24561250 | p(HGNC:PYCARD) increases p(HGNC:IL18) |
| pubmed:24561250 | p(HGNC:PYCARD) increases p(HGNC:IL1B) |
| pubmed:24561250 | p(HGNC:PYCARD) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23516100 | p(HGNC:CASP1) increases p(HGNC:MAPT, frag("?")) |
| pubmed:21722302 | act(p(HGNC:CASP1)) increases bp(MESH:"Cell Death") |
| pubmed:28019679 | p(HGNC:CASP1) increases act(p(HGNC:IL18)) |
| pubmed:23702978 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) |
| pubmed:23702978 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) |
| pubmed:23702978 | act(p(HGNC:CASP1)) increases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:24561250 | p(HGNC:CASP1) increases p(HGNC:IL18) |
| pubmed:24561250 | p(HGNC:CASP1) increases p(HGNC:IL18) |
| pubmed:27314526 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) |
| pubmed:27314526 | tloc(p(HGNC:CASP1), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases act(p(HGNC:IL18)) |
| pubmed:27314526 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) |
| pubmed:27314526 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) |
| pubmed:28019679 | p(HGNC:CASP1) increases act(p(HGNC:IL1B)) |
| pubmed:23702978 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) |
| pubmed:23702978 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) |
| pubmed:23702978 | act(p(HGNC:CASP1)) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:23702978 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) |
| pubmed:24561250 | p(HGNC:CASP1) increases p(HGNC:IL1B) |
| pubmed:27314526 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) |
| pubmed:27314526 | tloc(p(HGNC:CASP1), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases act(p(HGNC:IL1B)) |
| pubmed:27314526 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) |
| pubmed:27314526 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) |
| pubmed:28019679 | act(p(HGNC:CASP1)) increases a(CHEBI:"nitric oxide") |
| pubmed:28019679 | act(p(HGNC:CASP1)) increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28019679 | act(p(HGNC:CASP1)) increases bp(GO:pyroptosis) |
| pubmed:23702978 | act(p(HGNC:CASP1)) increases bp(GO:pyroptosis) |
| pubmed:24561250 | p(HGNC:CASP1) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pubmed:27314526 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL33)) |
| pubmed:27314526 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL33)) |
| pubmed:30962309 | a(MESH:Brain) increases r(HGNC:NLRP3, loc(MESH:Microglia)) |
| pubmed:29661268 | a(MESH:Brain) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:27758088 | a(MESH:Brain) association r(HGNC:CHRNA5) |
| pubmed:27758088 | a(MESH:Brain) association r(HGNC:CHRNA3) |
| pubmed:21482353 | act(a(MESH:Brain)) negativeCorrelation act(p(FPLX:CHRN)) |
| pubmed:22299660 | a(MESH:Brain) association p(HGNC:PPP2R2A) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-20a) association a(MESH:"Neural Pathways") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-20a) association a(MESH:"Immune System") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-20a) decreases p(HGNC:TXNIP) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-20a) decreases p(HGNC:TXNIP) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-20a) decreases p(HGNC:NLRP3) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-20a) regulates complex(MESH:Inflammasomes) |
| pubmed:30962309 | a(MESH:"Neural Pathways") association m(MIRBASE:hsa-mir-20a) |
| pubmed:30962309 | a(MESH:"Neural Pathways") association m(MIRBASE:hsa-mir-30a) |
| pubmed:30962309 | a(MESH:"Neural Pathways") association m(MIRBASE:hsa-mir-146a) |
| pubmed:30988501 | a(MESH:"Neural Pathways") increases act(a(MESH:Brain)) |
| pubmed:30988501 | a(MESH:"Neural Pathways") increases p(HGNC:TNF) |
| pubmed:30962309 | a(MESH:"Immune System") association m(MIRBASE:hsa-mir-20a) |
| pubmed:30962309 | a(MESH:"Immune System") association m(MIRBASE:hsa-mir-30a) |
| pubmed:30962309 | a(MESH:"Immune System") association m(MIRBASE:hsa-mir-146a) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-30a) association a(MESH:"Neural Pathways") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-30a) association a(MESH:"Immune System") |
| pubmed:30962309 | p(HGNC:DGCR8) increases r(MESH:MicroRNAs) |
| pubmed:30962309 | p(HGNC:XPO5) increases p(MESH:"RNA-Binding Proteins", loc(GO:cytoplasm)) |
| pubmed:30837838 | p(MESH:"RNA-Binding Proteins") association path(MESH:"RNA Stability") |
| pubmed:30837838 | p(MESH:"RNA-Binding Proteins") association bp(GO:"mRNA processing") |
| pubmed:30837838 | p(MESH:"RNA-Binding Proteins") association path(MESH:"RNA Transport") |
| pubmed:30962309 | composite(p(HGNC:DICER1), p(MESH:"RNA-Binding Proteins")) increases complex(p(MESH:MicroRNAs), p(MESH:MicroRNAs)) |
| pubmed:30962309 | p(MESH:MicroRNAs) directlyDecreases bp(GO:"mRNA polyadenylation") |
| pubmed:30962309 | p(MESH:MicroRNAs) directlyDecreases path(MESH:"RNA Stability") |
| pubmed:30962309 | p(MESH:MicroRNAs) directlyIncreases bp(GO:"exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-independent decay") |
| pubmed:30962309 | p(MESH:MicroRNAs) directlyDecreases bp(GO:translation) |
| pubmed:30962309 | composite(p(HGNC:NCOA6), p(MESH:"RNA-Binding Proteins")) increases complex(p(MESH:MicroRNAs), p(MESH:MicroRNAs)) |
| pubmed:30962309 | composite(p(HGNCGENEFAMILY:"Argonaute/PIWI family"), p(MESH:MicroRNAs), p(MESH:MicroRNAs)) increases composite(p(HGNCGENEFAMILY:"Argonaute/PIWI family"), p(MESH:MicroRNAs)) |
| pubmed:30962309 | composite(p(HGNCGENEFAMILY:"Argonaute/PIWI family"), p(MESH:MicroRNAs)) directlyDecreases path(MESH:"RNA Stability") |
| pubmed:30962309 | composite(p(HGNCGENEFAMILY:"Argonaute/PIWI family"), p(MESH:MicroRNAs)) directlyDecreases bp(GO:translation) |
| pubmed:30837838 | path(MESH:"RNA Stability") association p(MESH:"RNA-Binding Proteins") |
| pubmed:30837838 | path(MESH:"RNA Stability") association p(HGNC:TARDBP) |
| pubmed:30106381 | bp(GO:translation) association p(HGNC:MTOR) |
| pubmed:27181519 | bp(GO:translation) negativeCorrelation complex(GO:"cytoplasmic stress granule") |
| pubmed:30837838 | bp(GO:translation) negativeCorrelation p(HGNC:TARDBP, var("p.Ala315Thr")) |
| pubmed:30837838 | bp(GO:translation) negativeCorrelation p(HGNC:TARDBP, var("p.Gln343Arg")) |
| pubmed:30837838 | bp(GO:translation) negativeCorrelation p(HGNC:TARDBP, var("p.Asn352Ser")) |
| pubmed:30837838 | bp(GO:translation) negativeCorrelation p(HGNC:TARDBP, var("p.Met337Val")) |
| pubmed:30837838 | bp(GO:translation) negativeCorrelation p(HGNC:TARDBP, var("p.Gly298Ser")) |
| pubmed:30837838 | bp(GO:translation) negativeCorrelation p(HGNC:TARDBP, var("p.Gly348Cys")) |
| pubmed:30837838 | bp(GO:translation) negativeCorrelation p(HGNC:TARDBP, var("p.Ala382Thr")) |
| pubmed:30837838 | bp(GO:translation) negativeCorrelation p(HGNC:TARDBP, var("p.Asp169Gly")) |
| pubmed:30837838 | bp(GO:translation) negativeCorrelation p(HGNC:TARDBP, var("p.Arg263Glu")) |
| pubmed:30962309 | bp(GO:"mRNA polyadenylation") increases path(MESH:"RNA Stability") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-223) association p(HGNC:NLRP3) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-223) negativeCorrelation bp(GO:"monocyte differentiation") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-223) negativeCorrelation r(HGNC:NLRP3) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-223) regulates complex(MESH:Inflammasomes) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-223) regulates complex(MESH:Inflammasomes) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-223) negativeCorrelation path(DOID:"rheumatoid arthritis") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-223) negativeCorrelation path(DOID:"multiple sclerosis") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-223) negativeCorrelation path(DOID:"systemic lupus erythematosus") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-223) positiveCorrelation p(MESH:"Rheumatoid Factor") |
| pubmed:30962309 | bp(GO:"monocyte differentiation") negativeCorrelation m(MIRBASE:hsa-mir-223) |
| pubmed:30962309 | bp(GO:"monocyte differentiation") positiveCorrelation p(HGNC:NLRP3) |
| pubmed:30962309 | m(MIRBASE:ebv-mir-BART15) regulates p(HGNC:NLRP3) |
| pubmed:30962309 | m(MIRBASE:ebv-mir-BART15) directlyDecreases p(HGNC:NLRP3) |
| pubmed:30962309 | m(MIRBASE:ebv-mir-BART15) increases path(DOID:"multiple sclerosis") |
| pubmed:30962309 | g(DBSNP:rs10802501) regulates composite(m(MIRBASE:ebv-mir-BART15), m(MIRBASE:hsa-mir-223), r(HGNC:NLRP3)) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-7-1) directlyIncreases p(CONSO:"alpha-synuclein aggregates") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-7-1) decreases r(HGNC:RELA) |
| pubmed:30962309 | p(CONSO:"alpha-synuclein aggregates") association path(DOID:"Parkinson's disease") |
| pubmed:26968346 | p(CONSO:"alpha-synuclein aggregates") negativeCorrelation bp(GO:"regulation of ER to Golgi vesicle-mediated transport") |
| pubmed:26968346 | p(CONSO:"alpha-synuclein aggregates") negativeCorrelation bp(GO:autophagy) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-30e) directlyIncreases p(CONSO:"alpha-synuclein aggregates") |
| pubmed:30962309 | path(DOID:"Parkinson's disease") association p(CONSO:"alpha-synuclein aggregates") |
| pubmed:30962309 | path(DOID:"Parkinson's disease") directlyDecreases m(MIRBASE:hsa-mir-7-1) |
| pubmed:30962309 | path(DOID:"Parkinson's disease") directlyIncreases m(MIRBASE:hsa-mir-22, loc(GO:"blood microparticle")) |
| pubmed:30515821 | path(DOID:"Parkinson's disease") negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | path(DOID:"Parkinson's disease") negativeCorrelation p(HGNC:PRKN) |
| pubmed:27190210 | path(DOID:"Parkinson's disease") association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:22530628 | path(DOID:"Parkinson's disease") association p(HGNC:CHRNA7) |
| pubmed:26979166 | path(DOID:"Parkinson's disease") increases deg(a(MESH:"Dopaminergic Neurons")) |
| pubmed:26979166 | path(DOID:"Parkinson's disease") increases deg(a(MESH:"Dopaminergic Neurons")) |
| pubmed:26979166 | path(DOID:"Parkinson's disease") increases path(DOID:"anxiety disorder") |
| pubmed:26979166 | path(DOID:"Parkinson's disease") increases path(MESH:Depression) |
| pubmed:26979166 | path(DOID:"Parkinson's disease") positiveCorrelation path(MESH:Depression) |
| pubmed:26979166 | path(DOID:"Parkinson's disease") decreases bp(GO:"learning or memory") |
| pubmed:26979166 | path(DOID:"Parkinson's disease") increases path(HP:Confusion) |
| pubmed:26979166 | path(DOID:"Parkinson's disease") increases path(DOID:dementia) |
| pubmed:26979166 | path(DOID:"Parkinson's disease") increases deg(a(MESH:"Cholinergic Neurons")) |
| pubmed:26979166 | path(DOID:"Parkinson's disease") decreases p(HGNC:CHAT) |
| pubmed:26979166 | path(DOID:"Parkinson's disease") negativeCorrelation path(MESH:Smoking) |
| pubmed:26979166 | path(DOID:"Parkinson's disease") negativeCorrelation path(MESH:Smoking) |
| pubmed:26979166 | path(DOID:"Parkinson's disease") negativeCorrelation path(MESH:Smoking) |
| pubmed:23516100 | path(DOID:"Parkinson's disease") increases p(HGNC:SNCA, frag("1_119")) |
| pubmed:23516100 | path(DOID:"Parkinson's disease") increases p(HGNC:SNCA, frag("1_120")) |
| pubmed:23516100 | path(DOID:"Parkinson's disease") increases p(HGNC:SNCA, frag("1_133")) |
| pubmed:23516100 | path(DOID:"Parkinson's disease") increases p(HGNC:SNCA, frag("1_122")) |
| pubmed:23516100 | path(DOID:"Parkinson's disease") negativeCorrelation bp(GO:"calcium ion homeostasis") |
| pubmed:23516100 | path(DOID:"Parkinson's disease") decreases act(p(HGNCGENEFAMILY:Calpains)) |
| pubmed:23516100 | path(DOID:"Parkinson's disease") increases act(p(HGNCGENEFAMILY:Calpains)) |
| pubmed:23516100 | path(DOID:"Parkinson's disease") increases complex(p(HGNC:SNCA), p(HGNCGENEFAMILY:Calpains)) |
| pubmed:21861815 | path(DOID:"Parkinson's disease") negativeCorrelation act(p(MESH:"Hypoxia-Inducible Factor 1")) |
| pubmed:26968346 | path(DOID:"Parkinson's disease") decreases p(HGNC:TFEB, loc(GO:nucleus)) |
| pubmed:27299292 | path(DOID:"Parkinson's disease") decreases p(HGNC:TFEB, loc(GO:nucleus)) |
| pubmed:26968346 | path(DOID:"Parkinson's disease") increases composite(p(HGNC:SNCA), p(HGNC:TFEB), loc(GO:"Lewy body")) |
| pubmed:27299292 | path(DOID:"Parkinson's disease") decreases a(MESH:Lysosomes) |
| pubmed:27299292 | path(DOID:"Parkinson's disease") increases complex(p(HGNC:SNCA), p(HGNC:TFEB)) |
| pubmed:27299292 | path(DOID:"Parkinson's disease") positiveCorrelation m(MIRBASE:hsa-mir-128-1) |
| pubmed:30562574 | path(DOID:"Parkinson's disease") association bp(GO:"chaperone-mediated autophagy") |
| pubmed:30562574 | path(DOID:"Parkinson's disease") association p(HGNC:PARK7) |
| pubmed:30562574 | path(DOID:"Parkinson's disease") association p(HGNC:PARK7) |
| pubmed:23384725 | path(DOID:"Parkinson's disease") association composite(a(MESH:"Inclusion Bodies"), p(HGNC:TARDBP)) |
| pubmed:30962309 | composite(m(MIRBASE:hsa-mir-7-1), p(CONSO:"alpha-synuclein aggregates")) increases path(DOID:"Parkinson's disease") |
| pubmed:30962309 | composite(m(MIRBASE:hsa-mir-30e), p(CONSO:"alpha-synuclein aggregates")) increases path(DOID:"Parkinson's disease") |
| pubmed:22372633 | path(DOID:"neurodegenerative disease") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:22372633 | path(DOID:"neurodegenerative disease") negativeCorrelation p(HGNC:HDAC6) |
| pubmed:30515821 | path(DOID:"neurodegenerative disease") negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | path(DOID:"neurodegenerative disease") association p(HGNC:MAPK1) |
| pubmed:23516100 | path(DOID:"neurodegenerative disease") positiveCorrelation p(HGNC:MAPT, frag("?")) |
| pubmed:23516100 | path(DOID:"neurodegenerative disease") positiveCorrelation p(HGNC:MAPT, frag("1_421")) |
| pubmed:23516100 | path(DOID:"neurodegenerative disease") negativeCorrelation bp(GO:"calcium ion homeostasis") |
| pubmed:23516100 | path(DOID:"neurodegenerative disease") decreases act(p(HGNCGENEFAMILY:Calpains)) |
| pubmed:27299292 | path(DOID:"neurodegenerative disease") negativeCorrelation act(p(HGNC:TFEB)) |
| pubmed:27299292 | path(DOID:"neurodegenerative disease") negativeCorrelation p(HGNC:TFEB) |
| pubmed:28669544 | path(DOID:"neurodegenerative disease") association path(MESH:"Protein Aggregation, Pathological") |
| pubmed:28669544 | path(DOID:"neurodegenerative disease") association path(MESH:"Neuronal Plasticity") |
| pubmed:28669544 | path(DOID:"neurodegenerative disease") association a(MESH:Microglia) |
| pubmed:30988501 | path(DOID:"neurodegenerative disease") positiveCorrelation bp(GO:pathogenesis) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-20b) regulates act(p(HGNC:NLRP3)) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-20b) directlyIncreases path(MESH:Inflammation) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-22) decreases r(HGNC:NLRP3) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-22) negativeCorrelation path(DOID:"coronary artery disease") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-22) positiveCorrelation path(MESH:"Cell Survival") |
| pubmed:30962309 | path(DOID:"coronary artery disease") negativeCorrelation m(MIRBASE:hsa-mir-22) |
| pubmed:30962309 | path(MESH:"Cell Survival") positiveCorrelation m(MIRBASE:hsa-mir-22) |
| pubmed:30740335 | path(MESH:"Cell Survival") association path(MESH:"Unfolded Protein Response") |
| pubmed:30837838 | path(MESH:"Cell Survival") association bp(GO:"vacuole fusion") |
| pubmed:30837838 | path(MESH:"Cell Survival") association path(MESH:"Endoplasmic Reticulum-Associated Degradation") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-133b) association r(HGNC:NLRP3) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-133b) decreases path(DOID:"allergic rhinitis") |
| pubmed:30962309 | path(DOID:"allergic rhinitis") decreases m(MIRBASE:hsa-mir-133b) |
| pubmed:30962309 | path(DOID:"allergic rhinitis") decreases path(HP:"Myocardial immune cell infiltration") |
| pubmed:30962309 | path(DOID:"allergic rhinitis") decreases a(MESH:Cytokines) |
| pubmed:30962309 | path(DOID:"allergic rhinitis") decreases complex(GO:"NLRP3 inflammasome complex") |
| pubmed:30962309 | path(DOID:"trigeminal neuralgia") decreases m(MIRBASE:hsa-mir-186) |
| pubmed:27889190 | path(DOID:"trigeminal neuralgia") association path(DOID:"relapsing-remitting multiple sclerosis") |
| pubmed:30962309 | path(MESH:Neuralgia) negativeCorrelation r(HGNC:NLRP3) |
| pubmed:30962309 | path(MESH:Neuralgia) negativeCorrelation act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:30962309 | path(DOID:"myocardial infarction") decreases m(MIRBASE:hsa-mir-495) |
| pubmed:30962309 | path(EFO:"ischemia reperfusion injury") decreases m(MIRBASE:hsa-mir-495) |
| pubmed:30962309 | composite(m(MIRBASE:hsa-mir-495), r(HGNC:NLRP3)) increases path(MESH:Inflammation) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-214) decreases p(HGNC:CASP1) |
| pubmed:30962309 | path(HP:"Anterior cortical cataract") directlyDecreases m(MIRBASE:hsa-mir-214) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-371a) association p(HGNC:CASP8, loc(GO:"inflammasome complex")) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-373) association p(HGNC:CASP8, loc(GO:"inflammasome complex")) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-543) association p(HGNC:CASP8, loc(GO:"inflammasome complex")) |
| pubmed:30962309 | path(DOID:"hepatocellular carcinoma") directlyIncreases m(MIRBASE:hsa-mir-371a) |
| pubmed:30962309 | path(DOID:"hepatocellular carcinoma") directlyIncreases m(MIRBASE:hsa-mir-373) |
| pubmed:30962309 | path(DOID:"hepatocellular carcinoma") directlyIncreases m(MIRBASE:hsa-mir-543) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-34a) regulates p(HGNC:CASP4) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-34a) regulates p(HGNC:CASP5) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-451a) regulates p(HGNC:CASP4) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-451a) regulates p(HGNC:CASP5) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-874) regulates p(HGNC:CASP4) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-874) regulates p(HGNC:CASP5) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-34c) negativeCorrelation p(OMIT:0016854) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-34c) decreases p(HGNCGENEFAMILY:"Toll like receptors") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-34c) decreases p(HGNC:IL1R1) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-34c) decreases r(HGNC:IKBKG) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-34c) negativeCorrelation path(EFO:"induces sterile inflammation") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-34c) decreases path(MESH:Inflammation) |
| pubmed:30962309 | p(OMIT:0016854) negativeCorrelation m(MIRBASE:hsa-mir-34c) |
| pubmed:30962309 | p(OMIT:0016854) negativeCorrelation m(MIRBASE:hsa-mir-146a) |
| pubmed:30962309 | p(OMIT:0016854) negativeCorrelation m(MIRBASE:hsa-mir-155) |
| pubmed:30962309 | p(OMIT:0016854) negativeCorrelation m(MIRBASE:hsa-mir-302b) |
| pubmed:30962309 | p(OMIT:0016854) negativeCorrelation m(MIRBASE:hsa-mir-330) |
| pubmed:30962309 | p(OMIT:0016854) increases r(HGNC:NLRP3) |
| pubmed:30962309 | p(OMIT:0016854) increases r(HGNC:NLRP3) |
| pubmed:30962309 | p(OMIT:0016854) increases r(HGNC:IL1B) |
| pubmed:30962309 | p(OMIT:0016854) increases r(HGNC:IL1B) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-302b) negativeCorrelation p(OMIT:0016854) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-302b) decreases p(HGNCGENEFAMILY:"Toll like receptors") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-302b) decreases p(HGNC:IL1R1) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-302b) directlyDecreases p(HGNC:IRAK4) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-302b) directlyDecreases r(HGNC:NLRP3) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-330) negativeCorrelation p(OMIT:0016854) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-330) decreases p(OMIT:0016854) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-330) decreases p(HGNCGENEFAMILY:"Tumor necrosis factor receptor superfamily") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-330) decreases p(HGNC:NLRP3) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-330) decreases p(HGNC:IL1B) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-330) decreases bp(GO:"sphingosine-1-phosphate receptor signaling pathway") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-330) decreases bp(GO:"sphingosine-1-phosphate receptor signaling pathway") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-330) decreases r(HGNC:NLRP3) |
| pubmed:30962309 | p(HGNCGENEFAMILY:"Toll like receptors") increases p(OMIT:0016854) |
| pubmed:30962309 | p(HGNC:IL1R1) increases p(OMIT:0016854) |
| pubmed:30962309 | p(HGNC:IL1R1) increases p(HGNC:IRAK4) |
| pubmed:30962309 | p(HGNCGENEFAMILY:"Tumor necrosis factor receptor superfamily") increases p(OMIT:0016854) |
| pubmed:30962309 | p(HGNC:MYD88) increases p(HGNC:IRAK1) |
| pubmed:30962309 | p(HGNC:MYD88) decreases path(MESH:Depression) |
| pubmed:30962309 | p(HGNC:IRAK1) increases p(OMIT:0016854) |
| pubmed:30962309 | p(HGNC:IRAK1) increases r(HGNC:NLRP3) |
| pubmed:30962309 | p(HGNC:IRAK1) increases r(HGNC:PYCARD) |
| pubmed:30962309 | p(HGNC:IRAK1) increases r(HGNC:CASP1) |
| pubmed:30962309 | p(HGNC:IRAK1) increases p(HGNC:NLRP3) |
| pubmed:30962309 | p(HGNC:IRAK1) increases p(HGNC:PYCARD) |
| pubmed:30962309 | p(HGNC:IRAK1) increases p(HGNC:CASP1) |
| pubmed:30962309 | p(HGNC:IRAK4) increases p(HGNC:TRAF6) |
| pubmed:30962309 | p(HGNC:IRAK4) directlyIncreases r(HGNC:NLRP3) |
| pubmed:30962309 | p(HGNCGENEFAMILY:"IKK complex") increases p(OMIT:0016854) |
| pubmed:30962309 | a(PUBCHEM:23697816) increases a(MESH:Macrophages) |
| pubmed:30935091 | path(MESH:Depression) positiveCorrelation p(HGNC:HDAC6) |
| pubmed:22950410 | path(MESH:Depression) association p(HGNC:CRHR1) |
| pubmed:16340157 | path(MESH:Depression) positiveCorrelation a(NIFT:"Grey matter atrophy") |
| pubmed:17009926 | path(MESH:Depression) association p(FPLX:CHRN) |
| pubmed:11230871 | path(MESH:Depression) association p(FPLX:CHRN) |
| pubmed:26813123 | path(MESH:Depression) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26979166 | path(MESH:Depression) positiveCorrelation path(DOID:"diabetes mellitus") |
| pubmed:26979166 | path(MESH:Depression) positiveCorrelation path(DOID:obesity) |
| pubmed:26979166 | path(MESH:Depression) positiveCorrelation path(DOID:"cardiovascular system disease") |
| pubmed:26979166 | path(MESH:Depression) positiveCorrelation path(MESH:Smoking) |
| pubmed:26979166 | path(MESH:Depression) positiveCorrelation path(MESH:Alcoholism) |
| pubmed:26979166 | path(MESH:Depression) positiveCorrelation bp(GO:"microglial cell activation") |
| pubmed:26979166 | path(MESH:Depression) positiveCorrelation path(DOID:"Parkinson's disease") |
| pubmed:21482353 | path(MESH:Depression) association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:19721446 | path(MESH:Depression) increases a(CHEBI:choline) |
| pubmed:28901280 | path(MESH:Depression) association p(MESH:"Receptors, Nicotinic") |
| pubmed:29687724 | path(MESH:Depression) association path(MESH:"Huntington Disease") |
| pubmed:30962309 | path(NCIT:C118474) directlyIncreases m(MIRBASE:hsa-mir-34c, loc(NCIT:C12954)) |
| pubmed:30962309 | path(EFO:"induces sterile inflammation") negativeCorrelation m(MIRBASE:hsa-mir-34c) |
| pubmed:30962309 | p(HGNC:IL1R2) directlyDecreases bp(GO:"interleukin-1-mediated signaling pathway") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-383) decreases p(HGNC:IL1R2) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-383) decreases p(HGNC:CASP1) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-383) decreases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-383) decreases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30962309 | path(DOID:atherosclerosis) decreases m(MIRBASE:hsa-mir-383) |
| pubmed:30962309 | path(DOID:atherosclerosis) increases p(HGNC:IL1R2) |
| pubmed:30962309 | path(EFO:"endothelial dysfunction") directlyIncreases m(MIRBASE:hsa-mir-383) |
| pubmed:30962309 | composite(p(HGNC:TNF), p(HGNC:TNFRSF1A)) increases p(HGNC:TRAF2) |
| pubmed:27794524 | p(HGNC:TNFRSF1A, loc(MESH:Neurons)) increases bp(GO:"neuron death") |
| pubmed:30962309 | p(HGNC:TRAF2) increases p(HGNC:SPHK1) |
| pubmed:22110360 | p(HGNC:TRAF2) increases act(p(HGNC:MAP3K5)) |
| pubmed:30962309 | p(HGNC:SPHK1) increases bp(GO:"sphingosine-1-phosphate receptor signaling pathway") |
| pubmed:30962309 | bp(GO:"sphingosine-1-phosphate receptor signaling pathway") increases act(p(OMIT:0016854)) |
| pubmed:30962309 | bp(GO:"sphingosine-1-phosphate receptor signaling pathway") increases r(HGNC:NLRP3) |
| pubmed:30962309 | bp(GO:"sphingosine-1-phosphate receptor signaling pathway") increases r(HGNC:NLRP3) |
| pubmed:30962309 | a(CHEBI:fructose) increases bp(GO:"sphingosine-1-phosphate receptor signaling pathway") |
| pubmed:30962309 | a(CHEBI:fructose) increases p(OMIT:0016854) |
| pubmed:30962309 | a(CHEBI:fructose) increases p(HGNC:NLRP3) |
| pubmed:30962309 | a(CHEBI:fructose) increases p(HGNC:IL1B) |
| pubmed:30962309 | a(CHEBI:fructose) increases m(MIRBASE:hsa-mir-377) |
| pubmed:30962309 | p(HGNC:IFNAR1) association a(PUBCHEM:223370366) |
| pubmed:30962309 | p(HGNC:IFNAR1) association a(NCIT:C20494) |
| pubmed:30962309 | p(HGNC:IFNAR1) increases bp(GO:"receptor signaling pathway via JAK-STAT") |
| pubmed:30962309 | p(HGNC:IFNAR1) increases act(complex(GO:"ISGF3 complex")) |
| pubmed:30962309 | p(HGNC:IFNAR1) increases r(HGNC:NLRP3) |
| pubmed:23702978 | act(p(HGNC:IFNAR1)) increases act(p(HGNC:SCAF11)) |
| pubmed:23702978 | p(HGNC:IFNAR1) increases act(p(HGNC:SCAF11)) |
| pubmed:30962309 | a(NCIT:C20494) association p(HGNC:IFNAR1) |
| pubmed:30962309 | bp(GO:"receptor signaling pathway via JAK-STAT") increases r(HGNC:NLRP3) |
| pubmed:19126755 | bp(GO:"receptor signaling pathway via JAK-STAT") increases act(a(CHEBI:nicotine)) |
| pubmed:27190210 | bp(GO:"receptor signaling pathway via JAK-STAT") decreases tloc(a(MESH:Cytokines), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27190210 | bp(GO:"receptor signaling pathway via JAK-STAT") decreases path(MESH:Inflammation) |
| pubmed:27190210 | bp(GO:"receptor signaling pathway via JAK-STAT") increases p(HGNC:HMOX1) |
| pubmed:30962309 | act(complex(GO:"ISGF3 complex")) increases r(HGNC:NLRP3) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-9-1) decreases p(HGNC:JAK1) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-9-1) regulates path(MESH:Inflammation) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-9-1) directlyDecreases r(HGNC:NLRP3) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-9-1) decreases r(HGNC:NFKB1) |
| pubmed:30962309 | a(CHEBI:"oxidised LDL") increases m(MIRBASE:hsa-mir-9-1) |
| pubmed:30962309 | p(HGNC:SOD1) decreases a(CHEBI:"reactive oxygen species") |
| pubmed:14556719 | p(HGNC:SOD1) decreases bp(GO:"response to oxidative stress") |
| pubmed:24563850 | p(HGNC:SOD1) increases rxn(reactants(a(CHEBI:superoxide)), products(a(CHEBI:"hydrogen peroxide"), a(CHEBI:dioxygen))) |
| pubmed:30837838 | p(HGNC:SOD1) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-377) decreases p(HGNC:SOD1) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-377) decreases p(HGNC:SOD2) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-377) increases a(CHEBI:"reactive oxygen species") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-377) increases p(HGNC:NLRP3) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-377) increases p(HGNC:PYCARD) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-377) increases p(HGNC:CASP1) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-377) increases p(HGNC:IL1B) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-377) association path(EFO:"metabolic syndrome") |
| pubmed:30962309 | path(EFO:"metabolic syndrome") association m(MIRBASE:hsa-mir-377) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-17) decreases p(HGNC:TXNIP) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-17) decreases p(HGNC:TXNIP) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-17) decreases p(HGNC:NLRP3) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-17) regulates complex(MESH:Inflammasomes) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-148a) decreases p(HGNC:TXNIP) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-148a) decreases p(HGNC:TXNIP) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-148a) decreases p(HGNC:NLRP3) |
| pubmed:30962309 | path(EFO:"Endoplasmic Reticulum Stress") decreases m(MIRBASE:hsa-mir-17) |
| pubmed:30962309 | path(EFO:"Endoplasmic Reticulum Stress") increases p(HGNC:TXNIP) |
| pubmed:30962309 | path(EFO:arthritis) decreases m(MIRBASE:hsa-mir-20a) |
| pubmed:30962309 | path(EFO:arthritis) increases p(HGNC:TXNIP) |
| pubmed:30962309 | path(DOID:"alcoholic hepatitis") decreases m(MIRBASE:hsa-mir-148a) |
| pubmed:30962309 | path(DOID:"alcoholic hepatitis") increases p(HGNC:TXNIP) |
| pubmed:30962309 | p(HGNC:CXCR4) increases p(HGNC:TXNIP) |
| pubmed:30962309 | p(HGNC:CXCR4) increases complex(GO:"NLRP3 inflammasome complex") |
| pubmed:30988501 | p(HGNC:CXCR4) increases bp(GO:"cell migration") |
| pubmed:30962309 | m(MIRBASE:hsa-mir-23a) decreases p(HGNC:CXCR4) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-23a) decreases act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-23a) decreases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-23a) increases path(MESH:Neuralgia) |
| pubmed:30962309 | composite(a(CHEBI:"oxidised LDL"), a(MESH:"Endothelial Cells")) decreases m(MIRBASE:hsa-mir-30c-1) |
| pubmed:30962309 | composite(a(CHEBI:"oxidised LDL"), a(MESH:"Endothelial Cells")) increases p(HGNC:FOXO3) |
| pubmed:19126755 | a(MESH:"Endothelial Cells") increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:28901280 | a(MESH:"Endothelial Cells") increases a(MESH:Acetylcholine) |
| pubmed:28901280 | a(MESH:"Endothelial Cells") increases a(MESH:"Choline O-Acetyltransferase") |
| pubmed:24027553 | a(MESH:"Endothelial Cells") increases tloc(a(CHEBI:Thrombin), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:24027553 | a(MESH:"Endothelial Cells") increases a(CHEBI:Thrombin) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-30c-1) decreases p(HGNC:FOXO3) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-30c-1) decreases r(HGNC:FOXO3) |
| pubmed:22179319 | p(HGNC:FOXO3) increases path(MESH:"Cell Survival") |
| pubmed:22179319 | p(HGNC:FOXO3) increases p(HGNC:BDNF) |
| pubmed:22179319 | p(HGNC:FOXO3) increases p(HGNC:PPP1R1B) |
| pubmed:22179319 | p(HGNC:FOXO3) decreases p(HGNC:HTT, pmod(CONSO:"CAG repeats")) |
| pubmed:30116051 | p(HGNC:FOXO3) increases bp(GO:macroautophagy) |
| pubmed:30962309 | r(HGNC:FOXO3) increases r(HGNC:NLRP3) |
| pubmed:30962309 | r(HGNC:FOXO3) increases p(HGNC:NLRP3) |
| pubmed:30962309 | r(HGNC:FOXO3) increases r(HGNC:CASP1) |
| pubmed:30962309 | r(HGNC:FOXO3) increases p(HGNC:CASP1) |
| pubmed:30962309 | r(HGNC:FOXO3) increases r(HGNC:IL1B) |
| pubmed:30962309 | r(HGNC:FOXO3) increases p(HGNC:IL1B) |
| pubmed:30962309 | path(NCIT:C78739) increases m(MIRBASE:hsa-mir-145) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-145) decreases m(MIRBASE:hsa-mir-145) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-145) increases g(HGNC:TNFRSF9) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-145) increases g(HGNC:NFATC1) |
| pubmed:30962309 | m(MIRBASE:hsa-mir-145) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:30962309 | g(HGNC:TNFRSF9) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:30962309 | g(HGNC:NFATC1) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:30962309 | path(DOID:"rheumatoid arthritis") negativeCorrelation m(MIRBASE:hsa-mir-146a) |
| pubmed:30962309 | path(DOID:"rheumatoid arthritis") directlyIncreases m(MIRBASE:hsa-mir-146a) |
| pubmed:30962309 | path(DOID:"rheumatoid arthritis") directlyDecreases m(MIRBASE:hsa-mir-146a, loc(MESH:"T-Lymphocytes, Regulatory")) |
| pubmed:30962309 | path(DOID:"rheumatoid arthritis") negativeCorrelation m(MIRBASE:hsa-mir-155) |
| pubmed:30962309 | path(DOID:"rheumatoid arthritis") directlyIncreases m(MIRBASE:hsa-mir-155) |
| pubmed:30962309 | path(DOID:"rheumatoid arthritis") negativeCorrelation m(MIRBASE:hsa-mir-223) |
| pubmed:30962309 | path(DOID:"rheumatoid arthritis") directlyIncreases m(MIRBASE:hsa-mir-223) |
| pubmed:30962309 | path(DOID:"rheumatoid arthritis") directlyIncreases m(MIRBASE:hsa-mir-223, loc(MESH:T-Lymphocytes)) |
| pubmed:30962309 | path(DOID:"rheumatoid arthritis") directlyDecreases m(MIRBASE:hsa-mir-22) |
| pubmed:30962309 | path(DOID:"rheumatoid arthritis") directlyDecreases m(MIRBASE:hsa-mir-9-1, loc(MESH:Plasma)) |
| pubmed:30962309 | path(DOID:"relapsing-remitting multiple sclerosis") directlyIncreases m(MIRBASE:hsa-mir-146a) |
| pubmed:30962309 | path(DOID:"relapsing-remitting multiple sclerosis") directlyIncreases m(MIRBASE:hsa-mir-9-1, loc(MESH:"Leukocytes, Mononuclear")) |
| pubmed:30962309 | path(DOID:"relapsing-remitting multiple sclerosis") decreases m(MIRBASE:hsa-mir-214) |
| pubmed:30962309 | path(DOID:"relapsing-remitting multiple sclerosis") increases m(MIRBASE:hsa-mir-17) |
| pubmed:27889190 | path(DOID:"relapsing-remitting multiple sclerosis") increases path(DOID:"secondary progressive multiple sclerosis") |
| pubmed:27889190 | path(DOID:"relapsing-remitting multiple sclerosis") association path(DOID:"optic neuritis") |
| pubmed:26445701 | path(DOID:"relapsing-remitting multiple sclerosis") increases path(DOID:"optic neuritis") |
| pubmed:30988501 | path(DOID:"relapsing-remitting multiple sclerosis") increases path(DOID:"optic neuritis") |
| pubmed:27889190 | path(DOID:"relapsing-remitting multiple sclerosis") association path(DOID:"internuclear ophthalmoplegia") |
| pubmed:27889190 | path(DOID:"relapsing-remitting multiple sclerosis") association path(DOID:"trigeminal neuralgia") |
| pubmed:27889190 | path(DOID:"relapsing-remitting multiple sclerosis") association path(DOID:"cerebellar ataxia") |
| pubmed:27889190 | path(DOID:"relapsing-remitting multiple sclerosis") association path(DOID:"pathologic nystagmus") |
| pubmed:27889190 | path(DOID:"relapsing-remitting multiple sclerosis") association path(HP:Myelopathy) |
| pubmed:27889190 | path(DOID:"relapsing-remitting multiple sclerosis") association path(HP:"Lhermitte's sign") |
| pubmed:27889190 | path(DOID:"relapsing-remitting multiple sclerosis") association path(HP:"Asymmetric limb muscle stiffness") |
| pubmed:27889190 | path(DOID:"relapsing-remitting multiple sclerosis") association path(MESH:"Erectile Dysfunction") |
| pubmed:27889190 | path(DOID:"relapsing-remitting multiple sclerosis") positiveCorrelation path(MESH:"Demyelinating Diseases") |
| pubmed:26445701 | path(DOID:"relapsing-remitting multiple sclerosis") increases path(DOID:myelitis) |
| pubmed:26445701 | path(DOID:"relapsing-remitting multiple sclerosis") increases path(HP:"Atrophy/Degeneration affecting the brainstem") |
| pubmed:27889190 | path(DOID:"relapsing-remitting multiple sclerosis") association complex(a(DRUGBANK:Fingolimod), p(HGNCGENEFAMILY:"Sphingosine 1-phosphate receptors")) |
| pubmed:30988501 | path(DOID:"relapsing-remitting multiple sclerosis") increases path(HP:Hemiparesis) |
| pubmed:30988501 | path(DOID:"relapsing-remitting multiple sclerosis") decreases bp(GO:cognition) |
| pubmed:30988501 | path(DOID:"relapsing-remitting multiple sclerosis") increases path(DOID:"mental depression") |
| pubmed:30962309 | path(DOID:"primary progressive multiple sclerosis") directlyDecreases m(MIRBASE:hsa-mir-23a) |
| pubmed:30962309 | path(DOID:"primary progressive multiple sclerosis") directlyDecreases m(MIRBASE:hsa-mir-223) |
| pubmed:27889190 | path(DOID:"primary progressive multiple sclerosis") increases path(HP:Paraparesis) |
| pubmed:27889190 | path(DOID:"primary progressive multiple sclerosis") increases path(HP:Hemiparesis) |
| pubmed:27889190 | path(DOID:"primary progressive multiple sclerosis") increases path(HP:Hemiparesis) |
| pubmed:27889190 | path(DOID:"primary progressive multiple sclerosis") increases path(DOID:"cerebellar ataxia") |
| pubmed:27889190 | path(DOID:"primary progressive multiple sclerosis") increases path(DOID:dementia) |
| pubmed:27889190 | path(DOID:"primary progressive multiple sclerosis") decreases path(MESH:"Visual Perception") |
| pubmed:27889190 | path(DOID:"primary progressive multiple sclerosis") increases path(HP:"Abnormality of the cerebrospinal fluid") |
| pubmed:27956442 | path(DOID:"primary progressive multiple sclerosis") directlyIncreases path(MESH:"Spinal Cord Diseases") |
| pubmed:27889190 | path(DOID:"primary progressive multiple sclerosis") increases path(NCIT:C21007) |
| pubmed:27889190 | path(DOID:"primary progressive multiple sclerosis") increases path(MESH:"Motor Disorders") |
| pubmed:27889190 | path(DOID:"primary progressive multiple sclerosis") increases path(HP:Myelopathy) |
| pubmed:27889190 | path(DOID:"primary progressive multiple sclerosis") increases path(HP:Ataxia) |
| pubmed:27889190 | path(DOID:"primary progressive multiple sclerosis") increases path(MESH:"Vision Disorders") |
| pubmed:27889190 | path(DOID:"primary progressive multiple sclerosis") decreases path(GO:cognition) |
| pubmed:30962309 | a(PUBCHEM:135314782) decreases path(DOID:"relapsing-remitting multiple sclerosis") |
| pubmed:30962309 | a(PUBCHEM:135314782) decreases m(MIRBASE:hsa-mir-17) |
| pubmed:30962309 | a(PUBCHEM:135314782) directlyIncreases m(MIRBASE:hsa-mir-7-1) |
| pubmed:30962309 | a(PUBCHEM:135314782) directlyIncreases m(MIRBASE:hsa-mir-20b) |
| pubmed:28843454 | a(PUBCHEM:135314782) decreases path(ORPHANET:477738) |
| pubmed:28843454 | a(PUBCHEM:135314782) isA path(MESH:"Home Infusion Therapy") |
| pubmed:27794524 | a(PUBCHEM:135314782) causesNoChange path(MESH:"Developmental Disabilities") |
| pubmed:27956442 | a(PUBCHEM:135314782) directlyDecreases p(HGNC:ITGA4) |
| pubmed:27956442 | a(PUBCHEM:135314782) directlyIncreases path(MESH:"JC Virus") |
| pubmed:27956442 | a(PUBCHEM:135314782) increases path(MESH:Headache) |
| pubmed:27956442 | a(PUBCHEM:135314782) increases path(MESH:Dizziness) |
| pubmed:27956442 | a(PUBCHEM:135314782) increases path(MESH:Exanthema) |
| pubmed:27956442 | a(PUBCHEM:135314782) increases path(MESH:Infection) |
| pubmed:30962309 | path(DOID:osteoarthritis) decreases m(MIRBASE:hsa-mir-22) |
| pubmed:30962309 | path(DOID:osteoarthritis) causesNoChange m(MIRBASE:hsa-mir-223) |
| pubmed:30962309 | path(DOID:osteoarthritis) causesNoChange m(MIRBASE:hsa-mir-155) |
| pubmed:30962309 | path(DOID:osteoarthritis) causesNoChange m(MIRBASE:hsa-mir-146a) |
| pubmed:30962309 | a(PUBCHEM:135335742) directlyDecreases path(DOID:"rheumatoid arthritis") |
| pubmed:30962309 | a(PUBCHEM:135335742) directlyIncreases m(MIRBASE:hsa-mir-22) |
| pubmed:30962309 | p(MESH:"Rheumatoid Factor") positiveCorrelation m(MIRBASE:hsa-mir-223) |
| pubmed:30962309 | path(DOID:arthritis) association m(MIRBASE:hsa-mir-146a, loc(MESH:"T-Lymphocytes, Regulatory")) |
| pubmed:30962309 | a(PUBCHEM:5280453) directlyDecreases m(MIRBASE:hsa-mir-155) |
| pubmed:30962309 | path(DOID:proteinuria) association m(MIRBASE:hsa-mir-155) |
| pubmed:30962309 | bp(GO:"glomerular filtration") association m(MIRBASE:hsa-mir-146a) |
| pubmed:30962309 | a(CHEBI:"mycophenolic acid") decreases path(DOID:"systemic lupus erythematosus") |
| pubmed:30962309 | a(CHEBI:"mycophenolic acid") increases m(MIRBASE:hsa-mir-146a, loc(MESH:T-Lymphocytes)) |
| pubmed:30962309 | g(DBSNP:rs57095329) regulates m(MIRBASE:hsa-mir-146a) |
| pubmed:30962309 | g(DBSNP:rs57095329) association path(DOID:"systemic lupus erythematosus") |
| pubmed:24586483 | g(DBSNP:rs57095329) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24586483 | g(DBSNP:rs57095329) negativeCorrelation bp(GO:cognition) |
| pubmed:24586483 | g(DBSNP:rs57095329) increases g(HGNC:MIR146A) |
| pubmed:30962309 | g(DBSNP:rs2431697) regulates m(MIRBASE:hsa-mir-146a) |
| pubmed:30962309 | g(DBSNP:rs2431697) association path(DOID:"systemic lupus erythematosus") |
| pubmed:30962309 | path(DOID:"lupus nephritis") directlyIncreases m(MIRBASE:hsa-mir-148a) |
| pubmed:30962309 | path(DOID:"Crohn's disease") directlyIncreases m(MIRBASE:hsa-mir-23a) |
| pubmed:30962309 | path(DOID:"Crohn's disease") directlyIncreases m(MIRBASE:hsa-mir-146a, loc(BTO:0000271)) |
| pubmed:30962309 | path(DOID:"Crohn's disease") directlyIncreases m(MIRBASE:hsa-mir-146a, loc(BTO:0001709)) |
| pubmed:30962309 | path(DOID:"ulcerative colitis") causesNoChange m(MIRBASE:hsa-mir-146a, loc(BTO:0000271)) |
| pubmed:30962309 | path(DOID:"ulcerative colitis") directlyIncreases m(MIRBASE:hsa-mir-146a, loc(BTO:0001709)) |
| pubmed:30962309 | path(MESH:Neuropathology) directlyDecreases m(MIRBASE:hsa-mir-34c) |
| pubmed:27889190 | bp(MESH:Sensation) association path(DOID:"multiple sclerosis") |
| pubmed:27889190 | path(MESH:"Mobility Limitation") association path(DOID:"multiple sclerosis") |
| pubmed:27889190 | bp(MESH:"Postural Balance") association path(DOID:"multiple sclerosis") |
| pubmed:27889190 | a(NCIT:C28381) association path(DOID:"multiple sclerosis") |
| pubmed:27889190 | bp(MESH:"Vision, Ocular") association path(DOID:"multiple sclerosis") |
| pubmed:27889190 | path(DOID:"secondary progressive multiple sclerosis") increases path(NCIT:C21007) |
| pubmed:27889190 | path(DOID:"secondary progressive multiple sclerosis") increases path(NCIT:C21007) |
| pubmed:27889190 | path(DOID:"secondary progressive multiple sclerosis") increases path(MESH:"Motor Disorders") |
| pubmed:27889190 | path(DOID:"secondary progressive multiple sclerosis") increases path(HP:Myelopathy) |
| pubmed:27889190 | path(DOID:"secondary progressive multiple sclerosis") increases path(HP:Hemiparesis) |
| pubmed:27889190 | path(DOID:"secondary progressive multiple sclerosis") increases path(HP:Ataxia) |
| pubmed:27889190 | path(DOID:"secondary progressive multiple sclerosis") increases path(MESH:"Vision Disorders") |
| pubmed:27889190 | path(DOID:"secondary progressive multiple sclerosis") decreases path(GO:cognition) |
| pubmed:27889190 | path(MESH:"Brain Injuries") prognosticBiomarkerFor path(DOID:"multiple sclerosis") |
| pubmed:27889190 | path(MESH:"Brain Injuries") prognosticBiomarkerFor path(DOID:"multiple sclerosis") |
| pubmed:22372633 | path(MESH:"Brain Injuries") increases p(HGNC:HDAC6) |
| pubmed:30988501 | path(MESH:"Brain Injuries") association a(MESH:"Th2 Cells") |
| pubmed:27889190 | path(DOID:"neuromyelitis optica") association complex(complex(GO:"IgG immunoglobulin complex"), p(HGNC:AQP4)) |
| pubmed:27889190 | path(DOID:"neuromyelitis optica") increases path(DOID:"optic neuritis") |
| pubmed:27889190 | path(DOID:"neuromyelitis optica") positiveCorrelation path(DOID:"optic neuritis") |
| pubmed:27889190 | path(DOID:"neuromyelitis optica") decreases path(MESH:"Visual Perception") |
| pubmed:27889190 | path(DOID:"neuromyelitis optica") increases path(DOID:myelitis) |
| pubmed:27889190 | path(DOID:"neuromyelitis optica") positiveCorrelation path(DOID:myelitis) |
| pubmed:27889190 | path(DOID:"neuromyelitis optica") increases path(HP:"Nausea and vomiting") |
| pubmed:27889190 | path(DOID:"neuromyelitis optica") increases path(MESH:Inflammation) |
| pubmed:27889190 | path(DOID:"neuromyelitis optica") increases path(MESH:"Brain Injuries") |
| pubmed:27889190 | path(DOID:"neuromyelitis optica") increases complex(p(HGNC:AQP4), p(MESH:"Immunoglobulin G")) |
| pubmed:30988501 | path(DOID:"neuromyelitis optica") isA path(DOID:"autoimmune disease of the nervous system") |
| pubmed:27889190 | complex(complex(GO:"IgG immunoglobulin complex"), p(HGNC:AQP4)) association path(DOID:"neuromyelitis optica") |
| pubmed:31413141 | complex(GO:"IgG immunoglobulin complex") causesNoChange p(HGNC:TREM2, frag("?"), loc(GO:"extracellular region")) |
| pubmed:30116051 | act(p(HGNC:AQP4)) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | p(HGNC:AQP4) association deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | p(HGNC:AQP4) decreases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | p(HGNC:AQP4) decreases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | p(HGNC:AQP4) increases a(HP:"glymphatic system") |
| pubmed:29626319 | p(HGNC:AQP4) increases a(HP:"glymphatic system") |
| pubmed:27889190 | path(DOID:"optic neuritis") association path(DOID:"relapsing-remitting multiple sclerosis") |
| pubmed:27889190 | path(DOID:"optic neuritis") isA path(MESH:"Demyelinating Diseases") |
| pubmed:27889190 | path(DOID:"optic neuritis") isA path(DOID:myelitis) |
| pubmed:27889190 | path(DOID:"optic neuritis") isA path(MESH:"Brain Stem Infarctions") |
| pubmed:27889190 | path(DOID:"optic neuritis") positiveCorrelation path(DOID:"neuromyelitis optica") |
| pubmed:27889190 | path(DOID:"internuclear ophthalmoplegia") association path(DOID:"relapsing-remitting multiple sclerosis") |
| pubmed:27889190 | path(DOID:"cerebellar ataxia") association path(DOID:"relapsing-remitting multiple sclerosis") |
| pubmed:27889190 | path(DOID:"pathologic nystagmus") association path(DOID:"relapsing-remitting multiple sclerosis") |
| pubmed:27889190 | path(HP:Myelopathy) association path(DOID:"relapsing-remitting multiple sclerosis") |
| pubmed:27889190 | path(HP:"Lhermitte's sign") association path(DOID:"relapsing-remitting multiple sclerosis") |
| pubmed:27889190 | path(HP:"Asymmetric limb muscle stiffness") association path(DOID:"relapsing-remitting multiple sclerosis") |
| pubmed:27889190 | path(MESH:"Erectile Dysfunction") association path(DOID:"relapsing-remitting multiple sclerosis") |
| pubmed:27889190 | path(MESH:"Demyelinating Diseases") positiveCorrelation path(DOID:"relapsing-remitting multiple sclerosis") |
| pubmed:30988501 | path(MESH:"Demyelinating Diseases") increases path(HP:"Axonal loss") |
| pubmed:27794524 | path(MESH:"Demyelinating Diseases") positiveCorrelation bp(GO:"inflammatory response") |
| pubmed:27794524 | path(MESH:"Demyelinating Diseases") positiveCorrelation path(MESH:"Tertiary Lymphoid Structures") |
| pubmed:27794524 | path(MESH:"Demyelinating Diseases") association bp(GO:"microglial cell activation") |
| pubmed:27794524 | path(MESH:"Demyelinating Diseases") increases path(MESH:"Neurodegenerative Diseases") |
| pubmed:27956442 | path(MESH:"Demyelinating Diseases") negativeCorrelation path(MESH:"Central Nervous System") |
| pubmed:27956442 | path(MESH:"Demyelinating Diseases") increases path(MESH:"Multiple Sclerosis, Relapsing-Remitting") |
| pubmed:27956442 | path(MESH:"Demyelinating Diseases") association path(MESH:Inflammation) |
| pubmed:27956442 | path(MESH:"Demyelinating Diseases") increases tloc(a(MESH:Lymphocytes), fromLoc(GO:cytoplasm), toLoc(MESH:Brain)) |
| pubmed:27889190 | path(DOID:myelitis) positiveCorrelation path(DOID:"neuromyelitis optica") |
| pubmed:21427723 | path(DOID:dementia) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:22530628 | path(DOID:dementia) positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:26979166 | path(DOID:dementia) positiveCorrelation p(MESH:Cholinesterases) |
| pubmed:26979166 | path(DOID:dementia) positiveCorrelation path(MESH:Smoking) |
| pubmed:30108137 | path(DOID:dementia) association r(HGNC:TFEB) |
| pubmed:27956442 | path(MESH:"Visual Perception") association path(MESH:"Multiple Sclerosis") |
| pubmed:25478017 | p(MESH:"Immunoglobulin G") increases complex(p(CONSO:"4R tau", var("p.151_391del")), p(MESH:"Immunoglobulin G")) |
| pubmed:27889190 | path(CONSO:neuroinflammation) increases a(MESH:"Oligoclonal Bands") |
| pubmed:24586483 | path(CONSO:neuroinflammation) association m(HGNC:MIR146A) |
| pubmed:26836182 | path(CONSO:neuroinflammation) positiveCorrelation bp(GO:"microglial cell activation") |
| pubmed:26836182 | path(CONSO:neuroinflammation) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26836182 | path(CONSO:neuroinflammation) positiveCorrelation p(HGNC:CHI3L1) |
| pubmed:26836182 | path(CONSO:neuroinflammation) positiveCorrelation p(HGNC:CCL2) |
| pubmed:27716675 | path(CONSO:neuroinflammation) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pubmed:27716675 | path(CONSO:neuroinflammation) positiveCorrelation a(CONSO:"Tau oligomers") |
| pubmed:27314526 | path(CONSO:neuroinflammation) association tloc(a(MESH:Interleukins), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30988501 | path(CONSO:neuroinflammation) decreases bp(GO:cognition) |
| pubmed:30988501 | path(CONSO:neuroinflammation) decreases act(a(MESH:Neurons)) |
| pubmed:27889190 | path(MESH:"Spinal Cord Injuries") positiveCorrelation path(DOID:"multiple sclerosis") |
| pubmed:27889190 | path(MESH:"Spinal Cord Injuries") prognosticBiomarkerFor path(DOID:"multiple sclerosis") |
| pubmed:24561250 | path(MESH:"Spinal Cord Injuries") increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pubmed:24561250 | path(MESH:"Spinal Cord Injuries") increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pubmed:24561250 | path(MESH:"Spinal Cord Injuries") increases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:24561250 | path(MESH:"Spinal Cord Injuries") increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:24561250 | path(MESH:"Spinal Cord Injuries") increases a(CHEBI:ATP) |
| pubmed:26445701 | path(HP:"CNS demyelination") biomarkerFor path(DOID:"multiple sclerosis") |
| pubmed:26445701 | path(HP:"CNS demyelination") increases a(HP:"Senile plaques") |
| pubmed:27889190 | path(HP:"CNS demyelination") positiveCorrelation path(MESH:Meningitis) |
| pubmed:30988501 | path(HP:"CNS demyelination") increases deg(a(MESH:"White Matter")) |
| pubmed:30988501 | path(HP:"CNS demyelination") decreases bp(MESH:Neuroprotection) |
| pubmed:30988501 | path(HP:"CNS demyelination") decreases bp(GO:"axonal transport") |
| pubmed:30988501 | path(HP:"CNS demyelination") decreases a(GO:"postsynaptic density") |
| pubmed:27889190 | path(MESH:"Optic Atrophy, Hereditary, Leber") increases path(MESH:"Vision, Low") |
| pubmed:27889190 | path(MESH:"Optic Atrophy, Hereditary, Leber") increases path(MESH:"Wounds and Injuries") |
| pubmed:27794524 | path(MESH:"Optic Atrophy, Hereditary, Leber") isA path(MESH:"Mitochondrial Diseases") |
| pubmed:30515821 | path(MESH:"Wounds and Injuries") association act(p(HGNC:CDK5)) |
| pubmed:30515821 | path(MESH:"Wounds and Injuries") association p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) |
| pubmed:30515821 | path(MESH:"Wounds and Injuries") negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:27889190 | path(DOID:"Behcet's disease") increases path(HP:Myelopathy) |
| pubmed:27889190 | path(DOID:"Behcet's disease") increases path(MESH:"Oral Ulcer") |
| pubmed:27889190 | path(DOID:"Behcet's disease") increases path(MESH:Ulcer) |
| pubmed:27889190 | path(DOID:"Behcet's disease") association path(DOID:"multiple sclerosis") |
| pubmed:27889190 | path(DOID:"Sjogren's syndrome") increases path(DOID:"optic neuritis") |
| pubmed:27889190 | path(DOID:"Sjogren's syndrome") increases path(DOID:myelitis) |
| pubmed:27889190 | path(DOID:"Sjogren's syndrome") increases path(MESH:"Abortion, Habitual") |
| pubmed:27889190 | path(DOID:"antiphospholipid syndrome") increases path(DOID:"optic neuritis") |
| pubmed:27889190 | path(DOID:"antiphospholipid syndrome") increases path(DOID:myelitis) |
| pubmed:27889190 | path(DOID:"antiphospholipid syndrome") increases path(MESH:"Abortion, Habitual") |
| pubmed:27889190 | path(DOID:"antiphospholipid syndrome") increases path(DOID:thrombosis) |
| pubmed:27889190 | path(DOID:CADASIL) increases path(DOID:migraine) |
| pubmed:27889190 | path(DOID:CADASIL) increases path(MESH:"Vascular Diseases") |
| pubmed:27889190 | path(DOID:CADASIL) increases path(HP:Hemiparesis) |
| pubmed:27889190 | path(DOID:CADASIL) increases path(DOID:dementia) |
| pubmed:27889190 | path(MESH:"Susac Syndrome") increases path(HP:Encephalopathy) |
| pubmed:27889190 | path(MESH:"Susac Syndrome") decreases path(MESH:"Visual Perception") |
| pubmed:27889190 | path(MESH:"Susac Syndrome") increases path(MESH:Deafness) |
| pubmed:27889190 | path(DOID:"central nervous system vasculitis") increases path(HP:Headache) |
| pubmed:27889190 | path(DOID:"central nervous system vasculitis") increases path(HP:Hemiparesis) |
| pubmed:27889190 | path(DOID:"central nervous system vasculitis") increases path(HP:Ataxia) |
| pubmed:27889190 | path(DOID:"central nervous system vasculitis") decreases bp(GO:cognition) |
| pubmed:27889190 | path(DOID:"central nervous system vasculitis") association path(DOID:"multiple sclerosis") |
| pubmed:27889190 | path(DOID:neurosarcoidosis) increases path(HP:"Optic neuropathy") |
| pubmed:27889190 | path(DOID:neurosarcoidosis) increases path(HP:Myelopathy) |
| pubmed:27889190 | path(DOID:neurosarcoidosis) increases path(HP:"Facial palsy") |
| pubmed:27889190 | path(DOID:neurosarcoidosis) association path(DOID:"multiple sclerosis") |
| pubmed:23383175 | path(MESH:"Neurologic Manifestations") association p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27889190 | path(MESH:"Central Nervous System Diseases") association path(DOID:"multiple sclerosis") |
| pubmed:27889190 | path(DOID:"leukoencephalopathy with vanishing white matter") association path(DOID:"multiple sclerosis") |
| pubmed:27889190 | path(MESH:"Vasculopathy, Retinal, With Cerebral Leukodystrophy") association path(DOID:"multiple sclerosis") |
| pubmed:27889190 | path(MESH:"Brain Diseases, Metabolic") association path(DOID:"multiple sclerosis") |
| pubmed:27889190 | path(DOID:"acute disseminated encephalomyelitis") increases path(HP:"CNS demyelination") |
| pubmed:27889190 | path(DOID:"acute disseminated encephalomyelitis") increases path(MESH:Leukocytosis) |
| pubmed:27889190 | path(DOID:"acute disseminated encephalomyelitis") increases p(MESH:Proteins) |
| pubmed:27889190 | path(DOID:"acute disseminated encephalomyelitis") increases path(HP:Encephalopathy) |
| pubmed:27889190 | path(DOID:"acute disseminated encephalomyelitis") association path(MESH:Consciousness) |
| pubmed:27889190 | path(DOID:"acute disseminated encephalomyelitis") association bp(GO:behavior) |
| pubmed:27889190 | path(DOID:"acute disseminated encephalomyelitis") association bp(GO:cognition) |
| pubmed:27889190 | path(MESH:Consciousness) association path(DOID:"acute disseminated encephalomyelitis") |
| pubmed:28843454 | path(MESH:"Life Style") association path(DOID:"multiple sclerosis") |
| pubmed:28843454 | path(MESH:Environment) association path(DOID:"multiple sclerosis") |
| pubmed:28843454 | path(NCIT:C68642) positiveCorrelation path(DOID:"multiple sclerosis") |
| pubmed:28843454 | path(MESH:Sunlight) association path(DOID:"multiple sclerosis") |
| pubmed:28843454 | path(MESH:Sunlight) decreases path(MESH:Mortality) |
| pubmed:28843454 | bp(GO:"response to light intensity") association path(DOID:"multiple sclerosis") |
| pubmed:28843454 | path(MESH:Work) decreases path(MESH:Mortality) |
| pubmed:28843454 | a(MESH:"Ultraviolet Rays") decreases path(EFO:"experimental autoimmune encephalomyelitis") |
| pubmed:28843454 | a(CHEBI:"24,25-Dihydroxyvitamin D") decreases path(DOID:"multiple sclerosis") |
| pubmed:28843454 | a(CHEBI:"24,25-Dihydroxyvitamin D") association path(DOID:"multiple sclerosis") |
| pubmed:28843454 | a(CHEBI:"24,25-Dihydroxyvitamin D") decreases path(DOID:"multiple sclerosis") |
| pubmed:28843454 | a(MESH:"Vitamin D") negativeCorrelation path(ORPHANET:477738) |
| pubmed:28843454 | a(MESH:"Vitamin D") negativeCorrelation path(DOID:"multiple sclerosis") |
| pubmed:28843454 | a(MESH:"Vitamin D") regulates path(MESH:"Gastrointestinal Microbiome") |
| pubmed:28843454 | path(ORPHANET:477738) negativeCorrelation a(MESH:"Vitamin D") |
| pubmed:28843454 | path(ORPHANET:477738) directlyIncreases path(MESH:"Epstein-Barr Virus Infections") |
| pubmed:28843454 | path(ORPHANET:477738) regulates path(MESH:"Gastrointestinal Microbiome") |
| pubmed:28843454 | path(ORPHANET:477738) increases composite(p(EFO:"Anti-Epstein-Barr virus early antigen IgG measurement"), p(NCIT:C52341)) |
| pubmed:28843454 | path(ORPHANET:477738) association path(EFO:"developmental disability") |
| pubmed:28843454 | path(ORPHANET:477738) association path(DOID:"mental depression") |
| pubmed:28843454 | path(ORPHANET:477738) association path(MESH:Fatigue) |
| pubmed:28843454 | path(ORPHANET:477738) decreases path(MESH:Exercise) |
| pubmed:28843454 | path(ORPHANET:477738) association path(DOID:"cognitive disorder") |
| pubmed:27794524 | path(MESH:"Epstein-Barr Virus Infections") association p(NCBIGENE:7707, loc(MESH:"Plasma Cells")) |
| pubmed:27794524 | path(MESH:"Epstein-Barr Virus Infections") directlyIncreases bp(GO:"CD8-positive, alpha-beta T cell differentiation involved in immune response") |
| pubmed:27956442 | path(MESH:"Epstein-Barr Virus Infections") positiveCorrelation path(MESH:"Multiple Sclerosis") |
| pubmed:26445701 | path(MESH:"Epstein-Barr Virus Infections") positiveCorrelation path(DOID:"multiple sclerosis") |
| pubmed:28843454 | p(NCIT:C52341) regulates bp(MESH:"Antibody Formation") |
| pubmed:30988501 | bp(MESH:"Antibody Formation") increases bp(MESH:"Adaptive Immunity") |
| pubmed:30988501 | bp(MESH:"Antibody Formation") association bp(GO:"embryonic brain development") |
| pubmed:28843454 | path(EFO:"cytomegalovirus infection") increases path(EFO:"Anti-cytomegalovirus IgG measurement") |
| pubmed:28843454 | path(EFO:"cytomegalovirus infection") decreases path(ORPHANET:477738) |
| pubmed:28843454 | path(EFO:"Anti-cytomegalovirus IgG measurement") decreases path(ORPHANET:477738) |
| pubmed:28843454 | path(EFO:"human herpesvirus 6 seropositivity") association path(DOID:"multiple sclerosis") |
| pubmed:30988501 | act(p(MESH:Antibodies)) increases bp(MESH:"Adaptive Immunity") |
| pubmed:28843454 | path(MESH:Smoking) increases path(DOID:"multiple sclerosis") |
| pubmed:26445701 | path(MESH:Smoking) increases path(DOID:"multiple sclerosis") |
| pubmed:28843454 | path(MESH:Smoking) increases path(EFO:"developmental disability") |
| pubmed:27956442 | path(MESH:Smoking) positiveCorrelation path(MESH:"Multiple Sclerosis") |
| pubmed:29196815 | path(MESH:Smoking) increases path(MESH:"Alzheimer Disease") |
| pubmed:29428175 | path(MESH:Smoking) positiveCorrelation g(HGNC:RHOA, var("?")) |
| pubmed:26979166 | path(MESH:Smoking) association path(DOID:schizophrenia) |
| pubmed:26979166 | path(MESH:Smoking) positiveCorrelation path(MESH:Depression) |
| pubmed:26979166 | path(MESH:Smoking) positiveCorrelation path(DOID:"bipolar disorder") |
| pubmed:26979166 | path(MESH:Smoking) negativeCorrelation path(DOID:"Parkinson's disease") |
| pubmed:26979166 | path(MESH:Smoking) negativeCorrelation path(DOID:"Parkinson's disease") |
| pubmed:26979166 | path(MESH:Smoking) negativeCorrelation path(DOID:"Parkinson's disease") |
| pubmed:26979166 | path(MESH:Smoking) positiveCorrelation path(DOID:dementia) |
| pubmed:26979166 | path(MESH:Smoking) positiveCorrelation path(DOID:"Alzheimer's disease") |
| pubmed:26979166 | path(MESH:Smoking) positiveCorrelation path(DOID:"Alzheimer's disease") |
| pubmed:21482353 | path(MESH:Smoking) decreases path(MESH:"Parkinson Disease") |
| pubmed:22807490 | path(MESH:Smoking) association path(MESH:"Hashimoto Disease") |
| pubmed:22807490 | path(MESH:Smoking) association path(MESH:"Colitis, Ulcerative") |
| pubmed:22807490 | path(MESH:Smoking) negativeCorrelation p(HGNC:TPO) |
| pubmed:28391535 | path(MESH:Smoking) increases a(MESH:"Blood Glucose") |
| pubmed:28843454 | a(MESH:"Tobacco, Smokeless") causesNoChange path(DOID:"multiple sclerosis") |
| pubmed:28843454 | a(CHEBI:nicotine) causesNoChange path(DOID:"multiple sclerosis") |
| pubmed:26979166 | a(CHEBI:nicotine) decreases path(DOID:"multiple sclerosis") |
| pubmed:19126755 | a(CHEBI:nicotine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19126755 | a(CHEBI:nicotine) decreases deg(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(GO:"endoplasmic reticulum"))) |
| pubmed:19126755 | a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19126755 | a(CHEBI:nicotine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19126755 | a(CHEBI:nicotine) causesNoChange p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19126755 | a(CHEBI:nicotine) regulates p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19126755 | a(CHEBI:nicotine) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19293145 | a(CHEBI:nicotine) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19293145 | a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:22530628 | a(CHEBI:nicotine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:30697142 | a(CHEBI:nicotine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19721446 | a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19721446 | act(a(CHEBI:nicotine)) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:28391535 | a(CHEBI:nicotine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19126755 | a(CHEBI:nicotine) causesNoChange a(MESH:Manduca) |
| pubmed:19126755 | a(CHEBI:nicotine) association path(CONSO:neurotoxicity) |
| pubmed:19293145 | a(CHEBI:nicotine) decreases path(CONSO:neurotoxicity) |
| pubmed:19126755 | a(CHEBI:nicotine) increases p(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:19126755 | a(CHEBI:nicotine) increases p(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:19126755 | a(CHEBI:nicotine) increases p(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:19126755 | a(CHEBI:nicotine) decreases act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:19293145 | act(a(CHEBI:nicotine)) increases p(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:21482353 | a(CHEBI:nicotine) increases act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:21482353 | a(CHEBI:nicotine) increases act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:21482353 | a(CHEBI:nicotine) increases act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:21482353 | a(CHEBI:nicotine) increases act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:21482353 | a(CHEBI:nicotine) increases act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:18174175 | a(CHEBI:nicotine) increases p(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:19126755 | a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:19126755 | a(CHEBI:nicotine) increases p(CONSO:"alpha-3 beta-2 nAChR") |
| pubmed:18174175 | a(CHEBI:nicotine) increases p(CONSO:"alpha-3 beta-2 nAChR") |
| pubmed:19126755 | a(CHEBI:nicotine) increases p(CONSO:"alpha-3 beta-4 nAChR") |
| pubmed:19126755 | a(CHEBI:nicotine) decreases complex(p(HGNC:CHRNA6), p(HGNC:CHRNB3)) |
| pubmed:19126755 | a(CHEBI:nicotine) increases act(p(FPLX:PI3K)) |
| pubmed:19293145 | a(CHEBI:nicotine) increases act(p(FPLX:PI3K)) |
| pubmed:19293145 | a(CHEBI:nicotine) increases act(p(FPLX:PI3K)) |
| pubmed:19126755 | a(CHEBI:nicotine) increases act(p(FPLX:PKA)) |
| pubmed:19126755 | a(CHEBI:nicotine) increases act(p(FPLX:PKC)) |
| pubmed:19126755 | a(CHEBI:nicotine) increases act(p(FPLX:"CAMK2_complex")) |
| pubmed:19126755 | act(a(CHEBI:nicotine)) increases act(p(FPLX:CREB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:19126755 | act(a(CHEBI:nicotine)) increases act(p(HGNC:ATF2), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:19126755 | act(a(CHEBI:nicotine)) increases act(p(RGD:Elk1), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:19126755 | act(a(CHEBI:nicotine)) increases act(p(HGNC:STAT3), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:19293145 | a(CHEBI:nicotine) association act(p(HGNC:STAT3)) |
| pubmed:19126755 | act(a(CHEBI:nicotine)) association a(MESH:Skin) |
| pubmed:19126755 | act(a(CHEBI:nicotine)) regulates bp(GO:"inflammatory response") |
| pubmed:23178521 | a(CHEBI:nicotine) regulates bp(GO:"inflammatory response") |
| pubmed:19126755 | a(CHEBI:nicotine) decreases path(MESH:"Colitis, Ulcerative") |
| pubmed:19126755 | a(CHEBI:nicotine) decreases path(MESH:"Inflammatory Bowel Diseases") |
| pubmed:19126755 | a(CHEBI:nicotine) decreases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:19293145 | a(CHEBI:nicotine) regulates act(p(HGNC:TNF)) |
| pubmed:19126755 | act(a(CHEBI:nicotine)) association path(MESH:"Genetic Variation") |
| pubmed:19126755 | a(CHEBI:nicotine) causesNoChange path(MESH:"Alzheimer Disease") |
| pubmed:19126755 | a(CHEBI:nicotine) causesNoChange p(MGI:Chrna4) |
| pubmed:19126755 | a(CHEBI:nicotine) decreases act(a(CHEBI:NS-398)) |
| pubmed:19126755 | a(CHEBI:nicotine) decreases bp(GO:"neuron death") |
| pubmed:19126755 | a(CHEBI:nicotine) decreases bp(GO:"neuron death") |
| pubmed:19126755 | a(CHEBI:nicotine) increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17009926 | a(CHEBI:nicotine) decreases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21482353 | a(CHEBI:nicotine) decreases a(CHEBI:dopamine) |
| pubmed:21482353 | a(CHEBI:nicotine) increases tloc(a(CHEBI:dopamine), fromLoc(MESH:"Presynaptic Terminals"), toLoc(GO:"extracellular region")) |
| pubmed:19721446 | a(CHEBI:nicotine) regulates tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28391535 | a(CHEBI:nicotine) increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28391535 | a(CHEBI:nicotine) increases act(a(CHEBI:dopamine)) |
| pubmed:19126755 | a(CHEBI:nicotine) increases path(MESH:"Behavior, Addictive") |
| pubmed:19126755 | a(CHEBI:nicotine) increases path(MESH:Craving) |
| pubmed:19126755 | a(CHEBI:nicotine) increases path(MESH:Anxiety) |
| pubmed:19126755 | a(CHEBI:nicotine) association act(p(HGNC:CHRNA7)) |
| pubmed:19293145 | a(CHEBI:nicotine) increases p(HGNC:CHRNA7) |
| pubmed:19293145 | a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7)) |
| pubmed:17009926 | a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7)) |
| pubmed:26472524 | a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7)) |
| pubmed:29428175 | a(CHEBI:nicotine) directlyIncreases act(p(HGNC:CHRNA7)) |
| pubmed:29428175 | a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) |
| pubmed:29428175 | a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7)) |
| pubmed:19126755 | a(CHEBI:nicotine) association p(CONSO:"beta-2-containing nAChR") |
| pubmed:19293145 | a(CHEBI:nicotine) increases bp(MESH:Neuroprotection) |
| pubmed:19293145 | act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection) |
| pubmed:19293145 | act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection) |
| pubmed:19293145 | act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection) |
| pubmed:19293145 | a(CHEBI:nicotine) increases bp(MESH:Neuroprotection) |
| pubmed:19721446 | a(CHEBI:nicotine) association bp(MESH:Neuroprotection) |
| pubmed:19293145 | a(CHEBI:nicotine) increases path(MESH:Cognition) |
| pubmed:19293145 | a(CHEBI:nicotine) decreases act(a(CHEBI:amyloid-beta)) |
| pubmed:25514383 | a(CHEBI:nicotine) decreases a(CHEBI:amyloid-beta) |
| pubmed:21958873 | a(CHEBI:nicotine) causesNoChange a(CHEBI:amyloid-beta) |
| pubmed:19293145 | a(CHEBI:nicotine) increases a(CHEBI:acetylcholine) |
| pubmed:19293145 | a(CHEBI:nicotine) increases complex(a(MESH:Bungarotoxins), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19293145 | a(CHEBI:nicotine) regulates composite(a(CHEBI:"3',5'-cyclic AMP"), p(FPLX:PKC)) |
| pubmed:19293145 | a(CHEBI:nicotine) decreases act(a(CHEBI:thapsigargin)) |
| pubmed:19293145 | act(a(CHEBI:nicotine)) decreases act(a(CHEBI:methamphetamine)) |
| pubmed:19293145 | a(CHEBI:nicotine) association bp(GO:"negative regulation of apoptotic process") |
| pubmed:19293145 | act(a(CHEBI:nicotine)) increases p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19293145 | act(a(CHEBI:nicotine)) increases p(HGNC:BCL2) |
| pubmed:19293145 | act(a(CHEBI:nicotine)) increases p(HGNC:BCL2L1) |
| pubmed:19293145 | a(CHEBI:nicotine) decreases bp(GO:"apoptotic process") |
| pubmed:19293145 | a(CHEBI:nicotine) decreases bp(GO:"apoptotic process") |
| pubmed:25514383 | a(CHEBI:nicotine) decreases bp(GO:"apoptotic process") |
| pubmed:19293145 | a(CHEBI:nicotine) decreases tloc(p(HGNC:BAX), fromLoc(GO:cytosol), toLoc(GO:mitochondrion)) |
| pubmed:19293145 | a(CHEBI:nicotine) increases act(p(HGNC:BAD)) |
| pubmed:19293145 | a(CHEBI:nicotine) increases complex(p(FPLX:"PI3K_p85"), p(HGNC:CHRNA7), p(HGNC:FYN)) |
| pubmed:19293145 | a(CHEBI:nicotine) increases act(p(HGNC:JAK2)) |
| pubmed:19293145 | act(a(CHEBI:nicotine)) increases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:nicotine) association p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19293145 | act(a(CHEBI:nicotine)) increases p(RGD:Mapk3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19293145 | act(a(CHEBI:nicotine)) increases p(RGD:Mapk14, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19293145 | act(a(CHEBI:nicotine)) increases p(RGD:Stat3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19293145 | a(CHEBI:nicotine) increases act(g(HGNC:NIN)) |
| pubmed:19293145 | a(CHEBI:nicotine) increases p(HGNC:PTGS2) |
| pubmed:19293145 | a(CHEBI:nicotine) increases a(CHEBI:"prostaglandin E2(1-)") |
| pubmed:19293145 | a(CHEBI:nicotine) increases bp(GO:"ERK1 and ERK2 cascade") |
| pubmed:19293145 | a(CHEBI:nicotine) increases bp(GO:"MAPK cascade") |
| pubmed:19293145 | act(a(CHEBI:nicotine)) increases composite(p(FPLX:JAK), p(HGNC:STAT3)) |
| pubmed:19293145 | a(CHEBI:nicotine) decreases act(a(CHEBI:"N-methyl-D-aspartic acid")) |
| pubmed:19293145 | a(CHEBI:nicotine) decreases a(MESH:Lipopolysaccharides) |
| pubmed:19293145 | a(CHEBI:nicotine) association bp(GO:"calcium-mediated signaling") |
| pubmed:19293145 | a(CHEBI:nicotine) association p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors") |
| pubmed:19293145 | a(CHEBI:nicotine) association p(HGNCGENEFAMILY:"Ryanodine receptors") |
| pubmed:19293145 | a(CHEBI:nicotine) association p(FPLX:ERK) |
| pubmed:19293145 | act(a(CHEBI:nicotine)) association a(MESH:Calcineurin) |
| pubmed:19293145 | a(CHEBI:nicotine) increases a(CHEBI:"calcium(2+)") |
| pubmed:19293145 | a(CHEBI:nicotine) decreases p(CONSO:sAPP-gamma) |
| pubmed:17009926 | a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) |
| pubmed:17009926 | a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) |
| pubmed:17009926 | a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) |
| pubmed:28445721 | a(CHEBI:nicotine) regulates p(FPLX:CHRN) |
| pubmed:21482353 | a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) |
| pubmed:21482353 | a(CHEBI:nicotine) increases p(FPLX:CHRN) |
| pubmed:21482353 | a(CHEBI:nicotine) increases p(FPLX:CHRN) |
| pubmed:21482353 | a(CHEBI:nicotine) causesNoChange p(FPLX:CHRN) |
| pubmed:21787755 | a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) |
| pubmed:17009926 | a(CHEBI:nicotine) increases bp(GO:memory) |
| pubmed:25514383 | a(CHEBI:nicotine) increases bp(GO:memory) |
| pubmed:11230871 | a(CHEBI:nicotine) increases bp(GO:memory) |
| pubmed:11230871 | a(CHEBI:nicotine) increases bp(GO:memory) |
| pubmed:17009926 | a(CHEBI:nicotine) increases bp(GO:"circadian sleep/wake cycle, wakefulness") |
| pubmed:22530628 | a(CHEBI:nicotine) decreases path(DOID:"Alzheimer's disease") |
| pubmed:22530628 | a(CHEBI:nicotine) positiveCorrelation path(MESH:Attention) |
| pubmed:11230871 | a(CHEBI:nicotine) increases path(MESH:Attention) |
| pubmed:22530628 | a(CHEBI:nicotine) causesNoChange bp(GO:"learning or memory") |
| pubmed:22530628 | a(CHEBI:nicotine) increases path(NCIT:C28004) |
| pubmed:22530628 | a(CHEBI:nicotine) increases path(MESH:Tachyphylaxis) |
| pubmed:30697142 | a(CHEBI:nicotine) increases path(MESH:Tachyphylaxis) |
| pubmed:22530628 | a(CHEBI:nicotine) increases path(MESH:"Tobacco Use Disorder") |
| pubmed:30697142 | a(CHEBI:nicotine) increases path(MESH:"Tobacco Use Disorder") |
| pubmed:30697142 | a(CHEBI:nicotine) increases path(MESH:"Tobacco Use Disorder") |
| pubmed:26813123 | a(CHEBI:nicotine) increases act(a(MESH:"Receptors, Nicotinic")) |
| pubmed:21958873 | a(CHEBI:nicotine) increases act(a(MESH:"Receptors, Nicotinic")) |
| pubmed:29428175 | a(CHEBI:nicotine) increases bp(MESH:"Calcium Signaling") |
| pubmed:29428175 | a(CHEBI:nicotine) regulates bp(GO:"T cell proliferation") |
| pubmed:29428175 | a(CHEBI:nicotine) regulates bp(GO:"cytokine secretion") |
| pubmed:26979166 | a(CHEBI:nicotine) decreases bp(GO:"microglial cell activation") |
| pubmed:26979166 | a(CHEBI:nicotine) decreases path(CONSO:neuroinflammation) |
| pubmed:26979166 | a(CHEBI:nicotine) decreases deg(a(MESH:"Dopaminergic Neurons")) |
| pubmed:21482353 | a(CHEBI:nicotine) decreases act(a(MESH:"Dopaminergic Neurons")) |
| pubmed:25514383 | a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:25514383 | a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:25514383 | a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pubmed:25514383 | a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pubmed:25514383 | a(CHEBI:nicotine) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pubmed:25514383 | a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:25514383 | a(CHEBI:nicotine) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pubmed:21482353 | a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:21482353 | a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:25514383 | a(CHEBI:nicotine) increases path(MESH:"Memory, Episodic") |
| pubmed:25514383 | a(CHEBI:nicotine) increases path(MESH:"Spatial Memory") |
| pubmed:25514383 | a(CHEBI:nicotine) decreases a(CONSO:"amyloid-beta oligomers") |
| pubmed:25514383 | a(CHEBI:nicotine) increases a(CONSO:"Tau aggregates") |
| pubmed:25514383 | a(CHEBI:nicotine) increases a(CONSO:"Tau aggregates") |
| pubmed:25514383 | a(CHEBI:nicotine) increases bp(GO:"p38MAPK cascade") |
| pubmed:25514383 | a(CHEBI:nicotine) decreases path(MESH:"Plaque, Amyloid") |
| pubmed:19721446 | a(CHEBI:nicotine) decreases path(MESH:"Plaque, Amyloid") |
| pubmed:25514383 | a(CHEBI:nicotine) increases bp(GO:"long-term synaptic potentiation") |
| pubmed:21482353 | a(CHEBI:nicotine) increases bp(GO:"long-term synaptic potentiation") |
| pubmed:30697142 | a(CHEBI:nicotine) increases a(CHEBI:"(-)-cotinine") |
| pubmed:30697142 | a(CHEBI:nicotine) increases a(CHEBI:nornicotine) |
| pubmed:30697142 | a(CHEBI:nicotine) increases a(CHEBI:nornicotine) |
| pubmed:30697142 | a(CHEBI:nicotine) increases a(CHEBI:Norcotinine) |
| pubmed:30697142 | a(CHEBI:nicotine) increases a(CHEBI:"nicotine N(1')-oxide") |
| pubmed:30697142 | a(CHEBI:nicotine) increases a(MESH:"nicotine N-glucuronide") |
| pubmed:30697142 | a(CHEBI:nicotine) increases a(CHEBI:"4-oxo-4-(pyridin-3-yl)butanoic acid") |
| pubmed:30697142 | a(CHEBI:nicotine) increases a(CHEBI:"butyric acid") |
| pubmed:30697142 | a(CHEBI:nicotine) increases a(PUBCHEM:25203099) |
| pubmed:30697142 | a(CHEBI:nicotine) increases path(MESH:"Substance Withdrawal Syndrome") |
| pubmed:30697142 | a(CHEBI:nicotine) increases path(MESH:"Cardiovascular Deconditioning") |
| pubmed:28445721 | a(CHEBI:nicotine) increases tloc(p(CONSO:CONSO00174), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) |
| pubmed:21482353 | a(CHEBI:nicotine) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNA4), p(HGNC:CHRNB2), p(HGNC:CHRNB2), p(HGNC:CHRNB2)) |
| pubmed:21482353 | a(CHEBI:nicotine) increases act(p(MGI:Lynx1)) |
| pubmed:21482353 | a(CHEBI:nicotine) increases bp(GO:cognition) |
| pubmed:19721446 | a(CHEBI:nicotine) increases bp(GO:cognition) |
| pubmed:21482353 | a(CHEBI:nicotine) causesNoChange p(CONSO:"alpha-4-containing nAChR") |
| pubmed:21482353 | a(CHEBI:nicotine) increases act(p(CONSO:"alpha-4-containing nAChR")) |
| pubmed:21482353 | a(CHEBI:nicotine) increases act(p(CONSO:"alpha-4-containing nAChR")) |
| pubmed:21482353 | a(CHEBI:nicotine) increases tloc(p(CONSO:"alpha-4-containing nAChR"), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:"extracellular region")) |
| pubmed:21482353 | a(CHEBI:nicotine) increases act(a(MESH:"GABAergic Neurons")) |
| pubmed:21482353 | a(CHEBI:nicotine) decreases path(CONSO:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") |
| pubmed:11230871 | a(CHEBI:nicotine) increases bp(GO:learning) |
| pubmed:19721446 | a(CHEBI:nicotine) increases bp(MESH:"Sensory Gating") |
| pubmed:19721446 | act(a(CHEBI:nicotine)) decreases path(MESH:Nociception) |
| pubmed:22040696 | a(CHEBI:nicotine) increases act(a(MESH:"SNARE Proteins")) |
| pubmed:18174175 | a(CHEBI:nicotine) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) |
| pubmed:18174175 | a(CHEBI:nicotine) increases a(MESH:"alpha6beta2 nicotinic acetylcholine receptor") |
| pubmed:21958873 | a(CHEBI:nicotine) causesNoChange tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21958873 | a(CHEBI:nicotine) causesNoChange tloc(p(CONSO:sAPP-alpha), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21958873 | a(CHEBI:nicotine) causesNoChange act(complex(GO:"NF-kappaB complex")) |
| pubmed:23178521 | a(CHEBI:nicotine) decreases act(p(MESH:"NF-kappa B")) |
| pubmed:28391535 | a(CHEBI:nicotine) increases act(a(MESH:"Adrenal Glands")) |
| pubmed:28391535 | a(CHEBI:nicotine) increases tloc(a(CHEBI:adrenaline), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28391535 | a(CHEBI:nicotine) decreases tloc(a(CHEBI:"insulin (human)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28391535 | a(CHEBI:nicotine) association complex(p(GO:"I-kappaB/NF-kappaB complex")) |
| pubmed:28391535 | a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), a(MESH:"nicotinic receptor alpha4beta2")) |
| pubmed:28391535 | a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), a(MESH:"nicotinic receptor alpha4beta2")) |
| pubmed:28391535 | a(CHEBI:nicotine) negativeCorrelation path(MESH:"Motor Activity") |
| pubmed:28391535 | a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), a(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:28391535 | a(CHEBI:nicotine) causesNoChange act(a(CHEBI:Mecamylamine)) |
| pubmed:28391535 | act(a(CHEBI:nicotine)) negativeCorrelation a(CHEBI:Hexamethonium) |
| pubmed:28843454 | a(MESH:"Tobacco Smoke Pollution") increases path(DOID:"multiple sclerosis") |
| pubmed:28843454 | path(EFO:"developmental disability") association path(ORPHANET:477738) |
| pubmed:28843454 | path(EFO:"developmental disability") association path(DOID:"multiple sclerosis") |
| pubmed:28843454 | path(MESH:"Pediatric Obesity") increases path(ORPHANET:477738) |
| pubmed:28843454 | path(MESH:"Body Weight") increases path(ORPHANET:477738) |
| pubmed:28843454 | path(MESH:"Body Mass Index") increases path(ORPHANET:477738) |
| pubmed:28843454 | bp(MESH:"Diet, Sodium-Restricted") positiveCorrelation path(EFO:"autoimmune disease") |
| pubmed:28843454 | bp(MESH:"Diet, Sodium-Restricted") decreases p(MESH:"Th17 Cells", var("?")) |
| pubmed:28843454 | bp(MESH:"Diet, Sodium-Restricted") decreases path(EFO:"experimental autoimmune encephalomyelitis") |
| pubmed:28843454 | path(EFO:"autoimmune disease") positiveCorrelation bp(MESH:"Diet, Sodium-Restricted") |
| pubmed:28843454 | p(MESH:"Th17 Cells", var("?")) increases path(EFO:"experimental autoimmune encephalomyelitis") |
| pubmed:28843454 | path(MESH:"Gastrointestinal Microbiome") regulates a(MESH:"Immune System") |
| pubmed:28843454 | path(MESH:"Gastrointestinal Microbiome") regulates path(MESH:Immunity) |
| pubmed:28843454 | path(MESH:"Gastrointestinal Microbiome") regulates bp(GO:"immune response") |
| pubmed:27794524 | path(MESH:Immunity) causesNoChange act(p(MESH:B-Lymphocytes)) |
| pubmed:28843454 | p(HGNCGENEFAMILY:"Histocompatibility complex") increases path(DOID:"multiple sclerosis") |
| pubmed:28843454 | p(HGNCGENEFAMILY:"Histocompatibility complex") association bp(GO:"immune response") |
| pubmed:30967783 | p(HGNCGENEFAMILY:"Histocompatibility complex") increases bp(GO:"T cell activation") |
| pubmed:28843454 | g(HGNCGENEFAMILY:"Histocompatibility complex") increases p(MESH:"Membrane Glycoproteins") |
| pubmed:26445701 | g(HGNCGENEFAMILY:"Histocompatibility complex") positiveCorrelation path(DOID:"multiple sclerosis") |
| pubmed:28843454 | p(MESH:"Membrane Glycoproteins") increases bp(GO:"T cell antigen processing and presentation") |
| pubmed:28843454 | g(IMGTHLA:HLA00865) positiveCorrelation path(DOID:"multiple sclerosis") |
| pubmed:28843454 | p(IMGTHLA:HLA00870) increases path(DOID:"multiple sclerosis") |
| pubmed:28843454 | p(MESH:"HLA Antigens") decreases path(DOID:"multiple sclerosis") |
| pubmed:28843454 | a(MESH:"DNA, Mitochondrial") association path(DOID:"multiple sclerosis") |
| pubmed:24561250 | deg(a(MESH:"DNA, Mitochondrial")) increases act(complex(GO:"inflammasome complex")) |
| pubmed:28843454 | bp(MESH:"Oxidative Phosphorylation") positiveCorrelation path(MESH:"Energy Metabolism") |
| pubmed:28843454 | path(MESH:"Energy Metabolism") positiveCorrelation bp(MESH:"Oxidative Phosphorylation") |
| pubmed:27794524 | path(MESH:"Energy Metabolism") directlyDecreases path(MESH:"Nerve Degeneration") |
| pubmed:27794524 | path(MESH:"Energy Metabolism") directlyDecreases bp(GO:"cell death") |
| pubmed:27956442 | path(MESH:"Energy Metabolism") negativeCorrelation bp(GO:"transport across blood-brain barrier") |
| pubmed:27956442 | path(MESH:"Energy Metabolism") negativeCorrelation path(MESH:Inflammation) |
| pubmed:27956442 | path(MESH:"Energy Metabolism") decreases path(MESH:"Amnesia, Anterograde") |
| pubmed:27956442 | path(MESH:"Energy Metabolism") decreases path(MESH:"Amnesia, Retrograde") |
| pubmed:28843454 | p(HGNC:HLA-DRB1) association path(DOID:"multiple sclerosis") |
| pubmed:28843454 | p(HGNC:HLA-DRB1) causesNoChange path(DOID:"multiple sclerosis") |
| pubmed:28843454 | p(HGNC:HLA-DRB1) increases path(DOID:"multiple sclerosis") |
| pubmed:28843454 | p(HGNC:HLA-DRB1) increases path(DOID:"multiple sclerosis") |
| pubmed:28843454 | p(HGNC:HLA-DRB1) increases path(ORPHANET:477738) |
| pubmed:28843454 | bp(GO:"DNA hypomethylation") increases p(HGNC:PADI2) |
| pubmed:28843454 | p(HGNC:PADI2) increases p(HGNC:MBP, var("?")) |
| pubmed:28843454 | p(HGNC:PADI2) decreases path(MESH:"Immune Tolerance") |
| pubmed:28843454 | p(HGNC:MBP, var("?")) decreases path(MESH:"Immune Tolerance") |
| pubmed:26445701 | p(HGNC:MBP) association a(MESH:"Glatiramer Acetate") |
| pubmed:26445701 | p(HGNC:MBP) isA a(MESH:Autoantigens) |
| pubmed:28843454 | g(HGNC:IFNG, var("NCIT:C121521")) increases p(HGNC:IFNG) |
| pubmed:28843454 | p(HGNC:IFNG) regulates bp(GO:"immune response") |
| pubmed:28843454 | p(HGNC:IFNG) regulates bp(GO:"T cell differentiation") |
| pubmed:27794524 | p(HGNC:IFNG) negativeCorrelation bp(GO:"glutamate homeostasis") |
| pubmed:27794524 | p(HGNC:IFNG) directlyDecreases a(MESH:Oligodendroglia) |
| pubmed:30967783 | p(HGNC:IFNG) increases a(NCIT:C156004) |
| pubmed:20100581 | p(HGNC:IFNG) increases bp(GO:"microglial cell activation") |
| pubmed:20100581 | p(HGNC:IFNG) increases bp(GO:"astrocyte activation") |
| pubmed:20100581 | p(HGNC:IFNG) association p(HGNC:NOS1) |
| pubmed:22807490 | p(HGNC:IFNG) increases p(HGNC:NOS2) |
| pubmed:23702978 | p(HGNC:IFNG) increases act(p(HGNC:NOS2)) |
| pubmed:22807490 | p(HGNC:IFNG) increases p(HGNC:PTGS2) |
| pubmed:23702978 | p(HGNC:IFNG) increases p(HGNC:AIM2) |
| pubmed:23702978 | p(HGNC:IFNG) decreases act(p(HGNC:NLRP3)) |
| pubmed:23702978 | p(HGNC:IFNG) increases p(HGNC:CARD17) |
| pubmed:28843454 | g(HGNC:FOXP3, var("NCIT:C121521")) increases p(HGNC:FOXP3) |
| pubmed:28843454 | p(HGNC:FOXP3) regulates bp(GO:"immune response") |
| pubmed:28843454 | p(HGNC:FOXP3) regulates bp(GO:"T cell differentiation") |
| pubmed:28843454 | g(HGNC:IL13, var("NCIT:C121521")) increases p(HGNC:IL13) |
| pubmed:28843454 | p(HGNC:IL13) regulates bp(GO:"immune response") |
| pubmed:28843454 | p(HGNC:IL13) regulates bp(GO:"T cell differentiation") |
| pubmed:30967783 | p(HGNC:IL13) increases act(a(NCIT:C123783)) |
| pubmed:30967783 | p(HGNC:IL13) decreases bp(GO:"inflammatory response") |
| pubmed:28843454 | g(HGNC:IL17A, var("NCIT:C121521")) increases p(HGNC:IL17A) |
| pubmed:28843454 | p(HGNC:IL17A) regulates bp(GO:"immune response") |
| pubmed:28843454 | p(HGNC:IL17A) regulates bp(GO:"T cell differentiation") |
| pubmed:30988501 | p(HGNC:IL17A) negativeCorrelation path(DOID:schizophrenia) |
| pubmed:30988501 | p(HGNC:IL17A) negativeCorrelation path(DOID:"mental depression") |
| pubmed:30988501 | p(HGNC:IL17A) negativeCorrelation path(DOID:"post-traumatic stress disorder") |
| pubmed:30988501 | p(HGNC:IL17A) increases path(HP:Autism) |
| pubmed:28843454 | g(HGNC:PTPN6) regulates a(MESH:"Immune System") |
| pubmed:28843454 | g(HGNC:PTPN6) decreases path(MESH:Inflammation) |
| pubmed:28843454 | p(HGNC:PTPN6, pmod(NCIT:C20102)) decreases g(HGNC:PTPN6) |
| pubmed:28843454 | p(HGNC:PTPN6, pmod(NCIT:C20102)) increases path(MESH:Inflammation) |
| pubmed:10887109 | p(HGNC:PTPN6) increases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:PTPN6, pmod(go:0006468 ! "protein phosphorylation", Tyr))) |
| pubmed:10887109 | p(HGNC:PTPN6) increases p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)) |
| pubmed:10887109 | p(HGNC:PTPN6) increases p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)) |
| pubmed:10887109 | p(HGNC:PTPN6) increases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:PTPN6)) |
| pubmed:28843454 | p(MESH:"Herpesvirus 1, Human") decreases p(HGNC:HLA-DRB1) |
| pubmed:28843454 | p(NCIT:C150640) increases path(DOID:"multiple sclerosis") |
| pubmed:28843454 | p(NCIT:C150640) increases path(DOID:"multiple sclerosis") |
| pubmed:28843454 | a(PUBCHEM:107970) decreases path(EFO:"relapsing-remitting multiple sclerosis") |
| pubmed:28843454 | a(PUBCHEM:107970) decreases path(ORPHANET:477738) |
| pubmed:28843454 | a(PUBCHEM:107970) isA path(MESH:"Administration, Oral") |
| pubmed:27956442 | a(PUBCHEM:107970) increases path(MESH:"Leukoencephalopathy, Progressive Multifocal") |
| pubmed:27956442 | a(PUBCHEM:107970) increases path(MESH:Cough) |
| pubmed:27956442 | a(PUBCHEM:107970) increases path(MESH:Headache) |
| pubmed:27956442 | a(PUBCHEM:107970) increases path(MESH:"Back Pain") |
| pubmed:27956442 | a(PUBCHEM:107970) increases path(MESH:Diarrhea) |
| pubmed:27956442 | a(PUBCHEM:107970) increases path(MESH:Infection) |
| pubmed:27956442 | a(PUBCHEM:107970) increases path(MESH:"Liver Diseases") |
| pubmed:27956442 | a(PUBCHEM:107970) increases path(MESH:Lymphopenia) |
| pubmed:27956442 | a(PUBCHEM:107970) increases path(MESH:"Macular Edema") |
| pubmed:28843454 | a(PUBCHEM:54684141) decreases path(EFO:"relapsing-remitting multiple sclerosis") |
| pubmed:28843454 | a(PUBCHEM:54684141) decreases path(ORPHANET:477738) |
| pubmed:28843454 | a(PUBCHEM:54684141) isA path(MESH:"Administration, Oral") |
| pubmed:27956442 | a(PUBCHEM:54684141) increases path(MESH:"Liver Diseases") |
| pubmed:27956442 | a(PUBCHEM:54684141) increases path(MESH:Diarrhea) |
| pubmed:27956442 | a(PUBCHEM:54684141) increases path(MESH:Alopecia) |
| pubmed:28843454 | a(PUBCHEM:637568) decreases path(EFO:"relapsing-remitting multiple sclerosis") |
| pubmed:28843454 | a(PUBCHEM:637568) decreases path(ORPHANET:477738) |
| pubmed:28843454 | a(PUBCHEM:637568) isA path(MESH:"Administration, Oral") |
| pubmed:27794524 | a(PUBCHEM:637568) increases p(HGNC:NFE2L2) |
| pubmed:27956442 | a(PUBCHEM:637568) increases path(MESH:"Leukoencephalopathy, Progressive Multifocal") |
| pubmed:27956442 | a(PUBCHEM:637568) increases path(MESH:Flushing) |
| pubmed:27956442 | a(PUBCHEM:637568) increases path(MESH:"Gastrointestinal Diseases") |
| pubmed:27956442 | a(PUBCHEM:637568) increases path(MESH:Lymphopenia) |
| pubmed:27956442 | a(PUBCHEM:637568) increases path(MESH:Exanthema) |
| pubmed:27956442 | a(PUBCHEM:637568) increases path(MESH:Ketosis) |
| pubmed:27956442 | a(PUBCHEM:637568) increases path(MESH:Proteinuria) |
| pubmed:27956442 | a(PUBCHEM:637568) increases path(MESH:"Liver Diseases") |
| pubmed:28843454 | a(PUBCHEM:135341754) decreases path(ORPHANET:477738) |
| pubmed:28843454 | a(PUBCHEM:135341754) isA path(MESH:"Home Infusion Therapy") |
| pubmed:28843454 | a(PUBCHEM:2907) decreases path(ORPHANET:477738) |
| pubmed:28843454 | a(PUBCHEM:2907) isA path(MESH:"Home Infusion Therapy") |
| pubmed:28843454 | a(PUBCHEM:135330159) decreases path(ORPHANET:477738) |
| pubmed:28843454 | a(PUBCHEM:135330159) isA path(MESH:"Home Infusion Therapy") |
| pubmed:27956442 | a(PUBCHEM:135330159) increases path(NCIT:C78251) |
| pubmed:27956442 | a(PUBCHEM:135330159) increases path(MESH:Headache) |
| pubmed:27956442 | a(PUBCHEM:135330159) increases path(MESH:Exanthema) |
| pubmed:27956442 | a(PUBCHEM:135330159) increases path(MESH:Fever) |
| pubmed:27956442 | a(PUBCHEM:135330159) increases path(MESH:Nausea) |
| pubmed:27956442 | a(PUBCHEM:135330159) increases path(MESH:Diarrhea) |
| pubmed:27956442 | a(PUBCHEM:135330159) increases path(MESH:Hypotension) |
| pubmed:27956442 | a(PUBCHEM:135330159) increases path(MESH:"Herpes Simplex") |
| pubmed:27956442 | a(PUBCHEM:135330159) increases path(MESH:"POEMS Syndrome") |
| pubmed:28843454 | a(PUBCHEM:46504469) decreases path(ORPHANET:477738) |
| pubmed:28843454 | a(PUBCHEM:46504469) isA p(MESH:"Antibodies, Monoclonal") |
| pubmed:28843454 | path(DOID:"mental depression") association path(ORPHANET:477738) |
| pubmed:28843454 | path(DOID:"mental depression") association path(DOID:"multiple sclerosis") |
| pubmed:26979166 | path(DOID:"mental depression") directlyIncreases act(a(MESH:Phagocytes)) |
| pubmed:30988501 | path(DOID:"mental depression") negativeCorrelation p(HGNC:IL6) |
| pubmed:30988501 | path(DOID:"mental depression") negativeCorrelation p(HGNC:IL2) |
| pubmed:30988501 | path(DOID:"mental depression") negativeCorrelation p(HGNC:IL1B) |
| pubmed:30988501 | path(DOID:"mental depression") negativeCorrelation p(HGNC:IL17A) |
| pubmed:30988501 | path(DOID:"mental depression") negativeCorrelation p(HGNC:CRP) |
| pubmed:30988501 | path(DOID:"mental depression") increases deg(a(MESH:Microglia)) |
| pubmed:30988501 | path(DOID:"mental depression") increases a(MESH:Microglia) |
| pubmed:30988501 | path(DOID:"mental depression") negativeCorrelation a(PUBCHEM:135305802) |
| pubmed:28843454 | path(MESH:Fatigue) association path(ORPHANET:477738) |
| pubmed:28843454 | path(MESH:Fatigue) association path(DOID:"multiple sclerosis") |
| pubmed:18986241 | path(MESH:Fatigue) association a(MESH:"Cholinesterase Inhibitors") |
| pubmed:28843454 | path(DOID:"cognitive disorder") association path(ORPHANET:477738) |
| pubmed:28843454 | path(DOID:"cognitive disorder") association path(DOID:"multiple sclerosis") |
| pubmed:30988501 | p(HGNC:IFNB1) decreases path(MESH:"Multiple Sclerosis, Relapsing-Remitting") |
| pubmed:30988501 | p(HGNC:IFNB1) isA a(CHEBI:"anti-inflammatory agent") |
| pubmed:30988501 | p(HGNC:IFNB1) increases path(NCIT:C78302) |
| pubmed:30988501 | p(HGNC:IFNB1) decreases path(DOID:"secondary progressive multiple sclerosis") |
| pubmed:26445701 | p(HGNC:IFNB1) decreases tloc(a(MESH:T-Lymphocytes), fromLoc(MESH:"Peripheral Nervous System"), toLoc(MESH:"Central Nervous System")) |
| pubmed:26445701 | p(HGNC:IFNB1) regulates act(a(MESH:T-Lymphocytes)) |
| pubmed:30967783 | p(HGNC:IFNB1) regulates a(MESH:T-Lymphocytes) |
| pubmed:26445701 | p(HGNC:IFNB1) association a(MESH:"Blood-Brain Barrier") |
| pubmed:26445701 | p(HGNC:IFNB1) regulates act(a(MESH:B-Lymphocytes)) |
| pubmed:30967783 | p(HGNC:IFNB1) regulates a(MESH:B-Lymphocytes) |
| pubmed:26445701 | p(HGNC:IFNB1) regulates bp(GO:"B cell cytokine production") |
| pubmed:26445701 | p(HGNC:IFNB1) regulates bp(GO:"T cell cytokine production") |
| pubmed:26445701 | p(HGNC:IFNB1) decreases path(DOID:"relapsing-remitting multiple sclerosis") |
| pubmed:26445701 | p(HGNC:IFNB1) increases path(DOID:"mental depression") |
| pubmed:30988501 | p(HGNC:IFNB1) increases path(DOID:"mental depression") |
| pubmed:26445701 | p(HGNC:IFNB1) increases p(MESH:Enzymes) |
| pubmed:26445701 | p(HGNC:IFNB1) increases path(DOID:"thyroid gland disease") |
| pubmed:26445701 | p(HGNC:IFNB1) increases path(DOID:leukopenia) |
| pubmed:26445701 | p(HGNC:IFNB1) increases path(MESH:"Injection Site Reaction") |
| pubmed:30967783 | p(HGNC:IFNB1) decreases path(DOID:"multiple sclerosis") |
| pubmed:30988501 | p(HGNC:IFNB1) biomarkerFor path(CONSO:neuroinflammation) |
| pubmed:30988501 | p(HGNC:IFNB1) biomarkerFor path(CONSO:Neurodegeneration) |
| pubmed:30988501 | path(MESH:"Multiple Sclerosis, Relapsing-Remitting") decreases bp(MESH:"Adaptive Immunity") |
| pubmed:30988501 | path(MESH:"Multiple Sclerosis, Relapsing-Remitting") increases path(MESH:Inflammation) |
| pubmed:27794524 | path(MESH:"Multiple Sclerosis, Relapsing-Remitting") increases path(MESH:Inflammation) |
| pubmed:27956442 | path(MESH:"Multiple Sclerosis, Relapsing-Remitting") association path(MESH:Inflammation) |
| pubmed:27794524 | path(MESH:"Multiple Sclerosis, Relapsing-Remitting") increases bp(GO:"inflammatory response") |
| pubmed:27794524 | path(MESH:"Multiple Sclerosis, Relapsing-Remitting") increases path(CONSO:"Clonal Expansion") |
| pubmed:27794524 | path(MESH:"Multiple Sclerosis, Relapsing-Remitting") causesNoChange path(MESH:Meningitis) |
| pubmed:27794524 | path(MESH:"Multiple Sclerosis, Relapsing-Remitting") causesNoChange path(MESH:Pathology) |
| pubmed:27794524 | path(MESH:"Multiple Sclerosis, Relapsing-Remitting") directlyDecreases a(PUBCHEM:65065) |
| pubmed:27956442 | path(MESH:"Multiple Sclerosis, Relapsing-Remitting") increases bp(GO:"transport across blood-brain barrier") |
| pubmed:22020111 | path(MESH:"Multiple Sclerosis, Relapsing-Remitting") negativeCorrelation a(PUBCHEM:400769) |
| pubmed:22020111 | path(MESH:"Multiple Sclerosis, Relapsing-Remitting") negativeCorrelation act(p(HGNC:NFE2L2)) |
| pubmed:30988501 | a(MESH:"Glatiramer Acetate") increases path(MESH:"Injection Site Reaction") |
| pubmed:26445701 | a(MESH:"Glatiramer Acetate") increases path(MESH:"Injection Site Reaction") |
| pubmed:30988501 | a(MESH:"Glatiramer Acetate") increases path(HP:Palpitations) |
| pubmed:26445701 | a(MESH:"Glatiramer Acetate") increases path(HP:Palpitations) |
| pubmed:30988501 | a(MESH:"Glatiramer Acetate") increases path(HP:"Chest tightness") |
| pubmed:26445701 | a(MESH:"Glatiramer Acetate") increases path(HP:"Chest tightness") |
| pubmed:30988501 | a(MESH:"Glatiramer Acetate") increases path(HP:Anxiety) |
| pubmed:26445701 | a(MESH:"Glatiramer Acetate") association p(HGNC:MBP) |
| pubmed:26445701 | a(MESH:"Glatiramer Acetate") decreases complex(a(GO:"myelin sheath"), a(MESH:T-Lymphocytes)) |
| pubmed:26445701 | a(MESH:"Glatiramer Acetate") increases complex(a(MESH:"Glatiramer Acetate"), a(MESH:T-Lymphocytes)) |
| pubmed:26445701 | a(MESH:"Glatiramer Acetate") increases bp(GO:"T-helper 2 cell cytokine production") |
| pubmed:26445701 | a(MESH:"Glatiramer Acetate") increases path(HP:Flushing) |
| pubmed:26445701 | a(MESH:"Glatiramer Acetate") increases path(HP:Dyspnea) |
| pubmed:26445701 | a(MESH:"Glatiramer Acetate") increases path(HP:Lipoatrophy) |
| pubmed:30967783 | a(MESH:"Glatiramer Acetate") decreases path(DOID:"multiple sclerosis") |
| pubmed:30967783 | a(MESH:"Glatiramer Acetate") regulates a(MESH:T-Lymphocytes) |
| pubmed:30967783 | a(MESH:"Glatiramer Acetate") regulates a(MESH:B-Lymphocytes) |
| pubmed:30967783 | a(MESH:"Glatiramer Acetate") increases bp(MESH:Neuroprotection) |
| pubmed:30988501 | a(DRUGBANK:Leflunomide) increases a(DRUGBANK:Teriflunomide) |
| pubmed:30988501 | a(DRUGBANK:Leflunomide) isA a(CHEBI:"EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor") |
| pubmed:30988501 | a(DRUGBANK:Leflunomide) decreases bp(MESH:"Cell Proliferation") |
| pubmed:30988501 | a(DRUGBANK:Teriflunomide) increases bp(MESH:Immunomodulation) |
| pubmed:30988501 | a(DRUGBANK:Teriflunomide) increases bp(MESH:"Immunoglobulin Class Switching") |
| pubmed:30988501 | a(DRUGBANK:Teriflunomide) increases path(HP:Headache) |
| pubmed:30988501 | a(DRUGBANK:Teriflunomide) increases p(MESH:Enzymes, loc(MESH:Liver)) |
| pubmed:30988501 | a(DRUGBANK:Teriflunomide) increases path(MESH:Diarrhea) |
| pubmed:30988501 | a(DRUGBANK:Teriflunomide) increases path(MESH:Alopecia) |
| pubmed:30988501 | a(DRUGBANK:Teriflunomide) increases path(MESH:Nausea) |
| pubmed:18986241 | path(MESH:Diarrhea) association a(MESH:"Cholinesterase Inhibitors") |
| pubmed:18986241 | path(MESH:Nausea) association a(MESH:"Cholinesterase Inhibitors") |
| pubmed:19721446 | path(MESH:Nausea) association a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") |
| pubmed:30988501 | a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) |
| pubmed:26445701 | a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) |
| pubmed:22020111 | a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) |
| pubmed:22020111 | a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) |
| pubmed:22020111 | a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) |
| pubmed:22020111 | a(CHEBI:"dimethyl fumarate") causesNoChange act(p(HGNC:NFE2L2)) |
| pubmed:22020111 | a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) |
| pubmed:30988501 | a(CHEBI:"dimethyl fumarate") isA a(CHEBI:antioxidant) |
| pubmed:30988501 | a(CHEBI:"dimethyl fumarate") decreases p(HGNC:NFKB1) |
| pubmed:30988501 | a(CHEBI:"dimethyl fumarate") decreases a(MESH:Cytokines) |
| pubmed:30988501 | a(CHEBI:"dimethyl fumarate") decreases path(MESH:Inflammation) |
| pubmed:30988501 | a(CHEBI:"dimethyl fumarate") increases path(MESH:Flushing) |
| pubmed:30988501 | a(CHEBI:"dimethyl fumarate") increases path(MESH:"Gastrointestinal Diseases") |
| pubmed:30988501 | a(CHEBI:"dimethyl fumarate") increases path(DOID:"progressive multifocal leukoencephalopathy") |
| pubmed:26445701 | a(CHEBI:"dimethyl fumarate") increases path(DOID:"progressive multifocal leukoencephalopathy") |
| pubmed:26445701 | a(CHEBI:"dimethyl fumarate") decreases path(DOID:"relapsing-remitting multiple sclerosis") |
| pubmed:26445701 | a(CHEBI:"dimethyl fumarate") decreases path(DOID:"multiple sclerosis") |
| pubmed:26445701 | a(CHEBI:"dimethyl fumarate") increases path(HP:Nausea) |
| pubmed:26445701 | a(CHEBI:"dimethyl fumarate") increases path(DOID:diarrhea) |
| pubmed:26445701 | a(CHEBI:"dimethyl fumarate") increases path(HP:"Abdominal pain") |
| pubmed:26445701 | a(CHEBI:"dimethyl fumarate") increases path(HP:Flushing) |
| pubmed:26445701 | a(CHEBI:"dimethyl fumarate") increases path(DOID:lymphopenia) |
| pubmed:29121589 | a(CHEBI:"dimethyl fumarate") increases p(FPLX:ERK, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29121589 | a(CHEBI:"dimethyl fumarate") increases p(FPLX:p38, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29121589 | a(CHEBI:"dimethyl fumarate") positiveCorrelation p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation", Ser, 473)) |
| pubmed:29121589 | a(CHEBI:"dimethyl fumarate") increases p(MGI:Gsk3b, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:29121589 | a(CHEBI:"dimethyl fumarate") decreases act(p(MGI:Gsk3b)) |
| pubmed:29121589 | a(CHEBI:"dimethyl fumarate") decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29121589 | a(CHEBI:"dimethyl fumarate") decreases p(MGI:Dpysl2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29121589 | a(CHEBI:"dimethyl fumarate") decreases path(CONSO:Astrogliosis) |
| pubmed:29121589 | a(CHEBI:"dimethyl fumarate") decreases path(CONSO:Microgliosis) |
| pubmed:29121589 | a(CHEBI:"dimethyl fumarate") decreases r(MGI:Il1b) |
| pubmed:29121589 | a(CHEBI:"dimethyl fumarate") decreases r(MGI:Nos2) |
| pubmed:29121589 | a(CHEBI:"dimethyl fumarate") decreases bp(GO:"inflammatory response") |
| pubmed:30988501 | complex(a(DRUGBANK:Fingolimod), p(HGNCGENEFAMILY:"Sphingosine 1-phosphate receptors")) decreases p(HGNCGENEFAMILY:"Sphingosine 1-phosphate receptors") |
| pubmed:30988501 | complex(a(DRUGBANK:Fingolimod), p(HGNCGENEFAMILY:"Sphingosine 1-phosphate receptors")) increases deg(p(HGNCGENEFAMILY:"Sphingosine 1-phosphate receptors")) |
| pubmed:27889190 | complex(a(DRUGBANK:Fingolimod), p(HGNCGENEFAMILY:"Sphingosine 1-phosphate receptors")) association path(DOID:"relapsing-remitting multiple sclerosis") |
| pubmed:30988501 | a(DRUGBANK:Fingolimod) decreases path(MESH:Recurrence) |
| pubmed:27889190 | a(DRUGBANK:Fingolimod) decreases path(MESH:Recurrence) |
| pubmed:30988501 | a(DRUGBANK:Fingolimod) increases path(HP:Bradycardia) |
| pubmed:30988501 | a(DRUGBANK:Fingolimod) increases path(MESH:"Atrioventricular Block") |
| pubmed:30988501 | a(DRUGBANK:Fingolimod) increases path(MESH:"Macular Edema") |
| pubmed:30988501 | a(DRUGBANK:Fingolimod) increases path(MESH:"Liver Function Tests") |
| pubmed:30988501 | a(DRUGBANK:Fingolimod) increases path(MESH:Infection) |
| pubmed:30988501 | a(DRUGBANK:Fingolimod) increases path(HP:"Herpes simplex encephalitis") |
| pubmed:30988501 | a(DRUGBANK:Fingolimod) increases path(HP:"Severe varicella zoster infection") |
| pubmed:27889190 | a(DRUGBANK:Fingolimod) decreases path(NCIT:C3824) |
| pubmed:19721446 | path(MESH:Recurrence) association p(HGNC:CHRNA3) |
| pubmed:19721446 | path(MESH:Recurrence) association p(HGNC:CHRNB4) |
| pubmed:30988501 | path(HP:"Herpes simplex encephalitis") decreases bp(GO:"learning or memory") |
| pubmed:30988501 | path(HP:"Herpes simplex encephalitis") increases path(HP:"Brain atrophy") |
| pubmed:30988501 | path(HP:"Herpes simplex encephalitis") increases complex(a(MESH:Autoantibodies), a(MESH:Neuropil)) |
| pubmed:30988501 | a(DRUGBANK:Natalizumab) increases path(MESH:"Opportunistic Infections") |
| pubmed:30988501 | a(DRUGBANK:Natalizumab) increases path(DOID:"progressive multifocal leukoencephalopathy") |
| pubmed:26445701 | a(DRUGBANK:Natalizumab) increases path(DOID:"progressive multifocal leukoencephalopathy") |
| pubmed:30988501 | a(DRUGBANK:Natalizumab) increases path(MESH:"Meningitis, Cryptococcal") |
| pubmed:30988501 | a(DRUGBANK:Natalizumab) isA p(MESH:"Antibodies, Monoclonal") |
| pubmed:30988501 | a(DRUGBANK:Natalizumab) decreases p(HGNC:ITGA4) |
| pubmed:30988501 | a(DRUGBANK:Natalizumab) decreases complex(p(HGNC:VCAM1), p(MESH:"Receptors, Very Late Antigen")) |
| pubmed:30988501 | a(DRUGBANK:Natalizumab) decreases tloc(a(MESH:Lymphocytes), fromLoc(MESH:Blood), toLoc(MESH:Brain)) |
| pubmed:26445701 | a(DRUGBANK:Natalizumab) isA p(MESH:"Antibodies, Monoclonal, Humanized") |
| pubmed:30967783 | a(DRUGBANK:Natalizumab) decreases path(DOID:"multiple sclerosis") |
| pubmed:30967783 | a(DRUGBANK:Natalizumab) regulates a(MESH:T-Lymphocytes) |
| pubmed:30967783 | a(DRUGBANK:Natalizumab) regulates a(MESH:B-Lymphocytes) |
| pubmed:27956442 | p(HGNC:ITGA4) isA a(MESH:"Cell Adhesion Molecules") |
| pubmed:26445701 | complex(p(HGNC:VCAM1), p(MESH:"Receptors, Very Late Antigen")) increases bp(MESH:"Transendothelial and Transepithelial Migration") |
| pubmed:28901280 | a(MESH:Lymphocytes) association r(HGNC:CHRFAM7A) |
| pubmed:30988501 | a(DRUGBANK:Alemtuzumab) isA p(MESH:"Antibodies, Monoclonal") |
| pubmed:30988501 | a(DRUGBANK:Alemtuzumab) increases complex(a(DRUGBANK:Alemtuzumab), p(HGNC:CD52)) |
| pubmed:30988501 | a(DRUGBANK:Alemtuzumab) increases deg(a(MESH:B-Lymphocytes)) |
| pubmed:30988501 | a(DRUGBANK:Alemtuzumab) increases deg(a(MESH:T-Lymphocytes)) |
| pubmed:30988501 | a(DRUGBANK:Alemtuzumab) decreases path(MESH:Recurrence) |
| pubmed:30988501 | a(DRUGBANK:Alemtuzumab) decreases path(DOID:"multiple sclerosis") |
| pubmed:30988501 | a(DRUGBANK:Alemtuzumab) increases path(MESH:"Injection Site Reaction") |
| pubmed:30988501 | a(DRUGBANK:Alemtuzumab) increases path(MESH:"Stomatitis, Herpetic") |
| pubmed:30988501 | a(DRUGBANK:Alemtuzumab) increases path(MESH:Mycoses) |
| pubmed:30988501 | a(DRUGBANK:Alemtuzumab) increases path(MESH:"Thyroid Diseases") |
| pubmed:30988501 | a(DRUGBANK:Alemtuzumab) increases path(DOID:thrombocytopenia) |
| pubmed:30988501 | a(DRUGBANK:Alemtuzumab) increases path(DOID:glomerulonephritis) |
| pubmed:30988501 | a(DRUGBANK:Alemtuzumab) increases path(MESH:"Autoimmune Diseases") |
| pubmed:30988501 | a(DRUGBANK:Alemtuzumab) decreases path(MESH:"Multiple Sclerosis, Relapsing-Remitting") |
| pubmed:27794524 | a(MESH:B-Lymphocytes) association path(MESH:"Tertiary Lymphoid Structures") |
| pubmed:26445701 | act(a(MESH:B-Lymphocytes)) increases deg(a(GO:"myelin sheath")) |
| pubmed:26445701 | a(MESH:B-Lymphocytes) association path(DOID:"multiple sclerosis") |
| pubmed:26445701 | a(MESH:B-Lymphocytes) increases path(MESH:Inflammation) |
| pubmed:30988501 | a(MESH:B-Lymphocytes) causesNoChange bp(GO:"learning or memory") |
| pubmed:30988501 | act(a(MESH:B-Lymphocytes)) association bp(GO:"embryonic brain development") |
| pubmed:30988501 | a(MESH:T-Lymphocytes) increases bp(MESH:"Immunologic Surveillance") |
| pubmed:30988501 | a(MESH:T-Lymphocytes) increases bp(GO:"cytokine secretion") |
| pubmed:30988501 | a(MESH:T-Lymphocytes) increases bp(GO:"learning or memory") |
| pubmed:30988501 | a(CHEBI:corticosteroid) decreases path(MESH:"Injection Site Reaction") |
| pubmed:27956442 | a(CHEBI:corticosteroid) decreases path(MESH:"Multiple Sclerosis, Relapsing-Remitting") |
| pubmed:26445701 | a(CHEBI:corticosteroid) decreases path(DOID:"relapsing-remitting multiple sclerosis") |
| pubmed:26445701 | a(CHEBI:corticosteroid) decreases path(MESH:Inflammation) |
| pubmed:26445701 | a(CHEBI:corticosteroid) isA a(CHEBI:immunomodulator) |
| pubmed:30988501 | a(MESH:"Histamine Antagonists") decreases path(MESH:"Injection Site Reaction") |
| pubmed:30988501 | a(DRUGBANK:Acyclovir) decreases path(MESH:"Stomatitis, Herpetic") |
| pubmed:30988501 | a(DRUGBANK:Acyclovir) decreases path(MESH:Mycoses) |
| pubmed:27794524 | path(MESH:"Autoimmune Diseases") association bp(GO:"microglial cell activation") |
| pubmed:30988501 | a(DRUGBANK:Daclizumab) isA p(MESH:"Antibodies, Monoclonal") |
| pubmed:30988501 | a(DRUGBANK:Daclizumab) decreases p(HGNC:IL2) |
| pubmed:30988501 | a(DRUGBANK:Daclizumab) decreases path(MESH:Recurrence) |
| pubmed:30988501 | a(DRUGBANK:Ocrelizumab) isA p(MESH:"Antibodies, Monoclonal") |
| pubmed:30988501 | a(DRUGBANK:Ocrelizumab) increases complex(a(DRUGBANK:Ocrelizumab), p(HGNC:MS4A1)) |
| pubmed:30988501 | a(DRUGBANK:Ocrelizumab) decreases path(MESH:Recurrence) |
| pubmed:30988501 | a(DRUGBANK:Rituximab) isA p(MESH:"Antibodies, Monoclonal") |
| pubmed:30988501 | a(DRUGBANK:Rituximab) increases complex(a(DRUGBANK:Ocrelizumab), p(HGNC:MS4A1)) |
| pubmed:30967783 | bp(MESH:"Adaptive Immunity") decreases p(MESH:Proteins, pmod(CONSO:misfolded)) |
| pubmed:30988501 | bp(MESH:"Adaptive Immunity") increases bp(GO:cognition) |
| pubmed:30988501 | bp(MESH:"Adaptive Immunity") increases bp(GO:"learning or memory") |
| pubmed:30988501 | bp(MESH:"Adaptive Immunity") increases path(MESH:Pathology) |
| pubmed:27794524 | bp(GO:"brain development") negativeCorrelation bp(GO:"inflammatory response") |
| pubmed:30985105 | bp(GO:"brain development") association p(HGNC:OGA) |
| pubmed:30988501 | bp(GO:"brain development") increases bp(GO:"complement-mediated synapse pruning") |
| pubmed:27794524 | bp(GO:"central nervous system development") positiveCorrelation bp(GO:"inflammatory response") |
| pubmed:27794524 | bp(GO:"central nervous system development") association a(CHEBI:laquinimod) |
| pubmed:27794524 | path(MESH:"Disease Resistance") decreases path(MESH:Inflammation) |
| pubmed:27794524 | path(MESH:"Multiple Sclerosis, Chronic Progressive") increases path(MESH:Inflammation) |
| pubmed:27956442 | path(MESH:"Multiple Sclerosis, Chronic Progressive") increases path(MESH:Inflammation) |
| pubmed:27794524 | path(MESH:"Multiple Sclerosis, Chronic Progressive") increases path(MESH:Atrophy) |
| pubmed:27956442 | path(MESH:"Multiple Sclerosis, Chronic Progressive") directlyIncreases path(MESH:Atrophy) |
| pubmed:27956442 | path(MESH:"Multiple Sclerosis, Chronic Progressive") directlyIncreases path(MESH:"Diffuse Axonal Injury") |
| pubmed:27794524 | path(MESH:B-Lymphocytes) association path(MESH:Meningitis) |
| pubmed:27794524 | path(MESH:Meningitis) association path(MESH:B-Lymphocytes) |
| pubmed:27794524 | path(MESH:Meningitis) increases bp(GO:"neuron death") |
| pubmed:27794524 | path(MESH:Meningitis) increases path(MESH:"Multiple Sclerosis, Chronic Progressive") |
| pubmed:27889190 | path(MESH:Meningitis) positiveCorrelation path(HP:"CNS demyelination") |
| pubmed:27794524 | p(MESH:B-Lymphocytes) increases path(MESH:"Antibody Formation") |
| pubmed:27794524 | p(MESH:B-Lymphocytes) increases tloc(a(MESH:Cytokines), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27794524 | p(MESH:B-Lymphocytes) increases path(MESH:"Antigen Presentation") |
| pubmed:27794524 | p(MESH:B-Lymphocytes) increases path(MESH:"Tertiary Lymphoid Structures") |
| pubmed:27794524 | p(MESH:B-Lymphocytes) increases path(MESH:"Wounds and Injuries") |
| pubmed:27794524 | path(MESH:"Tertiary Lymphoid Structures") association a(MESH:B-Lymphocytes) |
| pubmed:27794524 | path(MESH:"Tertiary Lymphoid Structures") association a(MESH:"Plasma Cells") |
| pubmed:27794524 | path(MESH:"Tertiary Lymphoid Structures") association a(MESH:"T-Lymphocytes, Helper-Inducer") |
| pubmed:27794524 | path(MESH:"Tertiary Lymphoid Structures") association a(MESH:"Dendritic Cells, Follicular") |
| pubmed:27794524 | path(MESH:"Tertiary Lymphoid Structures") positiveCorrelation path(MESH:"Neurodegenerative Diseases") |
| pubmed:27794524 | path(MESH:"Tertiary Lymphoid Structures") positiveCorrelation path(MESH:Atrophy) |
| pubmed:27794524 | path(MESH:"Tertiary Lymphoid Structures") positiveCorrelation path(MESH:"Demyelinating Diseases") |
| pubmed:27794524 | path(MESH:"Tertiary Lymphoid Structures") decreases path(MESH:"Age of Onset") |
| pubmed:27794524 | path(MESH:"Tertiary Lymphoid Structures") directlyIncreases bp(GO:"neuron death") |
| pubmed:27794524 | path(MESH:"Tertiary Lymphoid Structures") causesNoChange path(MESH:Meningitis) |
| pubmed:27794524 | path(MESH:"Tertiary Lymphoid Structures") causesNoChange path(MESH:Pathology) |
| pubmed:27794524 | p(HGNC:LTA) isA a(MESH:Cytokines) |
| pubmed:27794524 | p(HGNC:LTA) positiveCorrelation path(MESH:"Complement Activation") |
| pubmed:27794524 | p(HGNC:LTA) positiveCorrelation act(p(MESH:T-Lymphocytes)) |
| pubmed:27794524 | p(HGNC:IL10) regulates a(MESH:Cytokines) |
| pubmed:27794524 | p(HGNC:IL10) negativeCorrelation path(MESH:"Complement Activation") |
| pubmed:27794524 | p(HGNC:IL10) negativeCorrelation act(p(MESH:T-Lymphocytes)) |
| pubmed:30967783 | p(HGNC:IL10) increases act(a(NCIT:C123783)) |
| pubmed:30967783 | p(HGNC:IL10) decreases bp(GO:"inflammatory response") |
| pubmed:21718217 | p(HGNC:IL10) decreases a(MESH:Macrophages) |
| pubmed:27794524 | complex(p(HGNC:EBI3), p(HGNC:IL12A)) regulates a(MESH:Cytokines) |
| pubmed:27794524 | complex(p(HGNC:EBI3), p(HGNC:IL12A)) negativeCorrelation path(MESH:"Complement Activation") |
| pubmed:27794524 | complex(p(HGNC:EBI3), p(HGNC:IL12A)) negativeCorrelation act(p(MESH:T-Lymphocytes)) |
| pubmed:27794524 | path(MESH:"Complement Activation") positiveCorrelation p(HGNC:TNF) |
| pubmed:27794524 | path(MESH:"Complement Activation") positiveCorrelation p(HGNC:LTA) |
| pubmed:27794524 | path(MESH:"Complement Activation") positiveCorrelation p(HGNC:IL6) |
| pubmed:27794524 | path(MESH:"Complement Activation") negativeCorrelation p(HGNC:IL10) |
| pubmed:27794524 | path(MESH:"Complement Activation") negativeCorrelation complex(p(HGNC:EBI3), p(HGNC:IL12A)) |
| pubmed:27794524 | act(p(MESH:T-Lymphocytes)) positiveCorrelation p(HGNC:TNF) |
| pubmed:27794524 | act(p(MESH:T-Lymphocytes)) positiveCorrelation p(HGNC:LTA) |
| pubmed:27794524 | act(p(MESH:T-Lymphocytes)) positiveCorrelation p(HGNC:IL6) |
| pubmed:27794524 | act(p(MESH:T-Lymphocytes)) negativeCorrelation p(HGNC:IL10) |
| pubmed:27794524 | act(p(MESH:T-Lymphocytes)) negativeCorrelation complex(p(HGNC:EBI3), p(HGNC:IL12A)) |
| pubmed:27794524 | a(MESH:"Plasma Cells") association path(MESH:"Tertiary Lymphoid Structures") |
| pubmed:27794524 | a(MESH:"T-Lymphocytes, Helper-Inducer") association path(MESH:"Tertiary Lymphoid Structures") |
| pubmed:27794524 | a(MESH:"Dendritic Cells, Follicular") association path(MESH:"Tertiary Lymphoid Structures") |
| pubmed:27794524 | a(MESH:"Dendritic Cells, Follicular") increases tloc(p(HGNC:CXCL13), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27794524 | p(HGNC:CXCL13) positiveCorrelation a(MESH:"B-Cell Maturation Antigen") |
| pubmed:27794524 | p(HGNC:CXCL13) positiveCorrelation bp(GO:"regulation of B cell chemotaxis") |
| pubmed:27794524 | p(HGNC:CXCL13) positiveCorrelation bp(GO:"B cell selection") |
| pubmed:27794524 | a(MESH:"B-Cell Maturation Antigen") positiveCorrelation p(HGNC:CXCL13) |
| pubmed:27794524 | bp(GO:"regulation of B cell chemotaxis") positiveCorrelation p(HGNC:CXCL13) |
| pubmed:27794524 | bp(GO:"B cell selection") positiveCorrelation p(HGNC:CXCL13) |
| pubmed:27794524 | path(MESH:"Immunity, Humoral") causesNoChange path(MESH:"Tertiary Lymphoid Structures") |
| pubmed:27794524 | path(MESH:Atrophy) positiveCorrelation bp(GO:"inflammatory response") |
| pubmed:27794524 | path(MESH:Atrophy) positiveCorrelation path(MESH:"Tertiary Lymphoid Structures") |
| pubmed:27794524 | path(MESH:Atrophy) increases path(MESH:"Developmental Disabilities") |
| pubmed:27956442 | path(MESH:Atrophy) increases path(MESH:"Neurodegenerative Diseases") |
| pubmed:27956442 | path(MESH:Atrophy) directlyIncreases bp(GO:"microglial cell activation") |
| pubmed:27889190 | path(MESH:Atrophy) decreases bp(GO:cognition) |
| pubmed:27889190 | path(MESH:Atrophy) decreases bp(GO:cognition) |
| pubmed:27889190 | path(MESH:Atrophy) increases path(MESH:"Motor Disorders") |
| pubmed:27889190 | path(MESH:Atrophy) increases path(MESH:"Motor Disorders") |
| pubmed:27889190 | path(MESH:Atrophy) increases path(NCIT:C21007) |
| pubmed:25687773 | path(MESH:Atrophy) association g(DBSNP:rs393152) |
| pubmed:25687773 | path(MESH:Atrophy) positiveCorrelation g(DBSNP:rs393152) |
| pubmed:25687773 | path(MESH:Atrophy) association path(MESH:"Alzheimer Disease") |
| pubmed:26195256 | path(MESH:Atrophy) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:30012004 | path(MESH:Atrophy) positiveCorrelation path(MESH:"Huntington Disease") |
| pubmed:27794524 | path(MESH:Pathology) increases path(MESH:"Multiple Sclerosis, Chronic Progressive") |
| pubmed:27794524 | p(NCBIGENE:7707, loc(MESH:"Plasma Cells")) association path(MESH:"Epstein-Barr Virus Infections") |
| pubmed:27794524 | bp(GO:"CD8-positive, alpha-beta T cell differentiation involved in immune response") directlyIncreases a(MESH:Cytotoxins) |
| pubmed:30837838 | a(MESH:Cytotoxins) association p(HGNC:TARDBP, frag("274_414")) |
| pubmed:26445701 | a(MESH:"CD8-Positive T-Lymphocytes") increases path(DOID:"axonal neuropathy") |
| pubmed:26445701 | a(MESH:"CD8-Positive T-Lymphocytes") increases path(HP:"CNS demyelination") |
| pubmed:26445701 | a(MESH:"CD8-Positive T-Lymphocytes") increases path(MESH:"Diffuse Axonal Injury") |
| pubmed:26445701 | a(MESH:"CD8-Positive T-Lymphocytes") increases bp(GO:"positive regulation of oligodendrocyte apoptotic process") |
| pubmed:27794524 | a(MESH:"T-Lymphocytes, Cytotoxic") increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27794524 | a(MESH:"T-Lymphocytes, Cytotoxic") increases tloc(p(HGNC:IFNG), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27794524 | a(MESH:"T-Lymphocytes, Cytotoxic") increases tloc(p(HGNC:PRF1), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27794524 | a(MESH:"T-Lymphocytes, Cytotoxic") increases tloc(p(HGNC:GZMA), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27794524 | a(MESH:"T-Lymphocytes, Cytotoxic") increases tloc(p(HGNC:GZMB), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30988501 | a(MESH:"T-Lymphocytes, Cytotoxic") increases path(HP:"CNS demyelination") |
| pubmed:30988501 | a(MESH:"T-Lymphocytes, Cytotoxic") increases deg(a(MESH:Neurons)) |
| pubmed:27794524 | p(HGNC:PRF1) increases bp(GO:"sodium ion import across plasma membrane") |
| pubmed:27794524 | p(HGNC:PRF1) increases bp(GO:"calcium ion import") |
| pubmed:27794524 | p(HGNC:GZMA) increases bp(GO:"sodium ion import across plasma membrane") |
| pubmed:27794524 | p(HGNC:GZMA) increases bp(GO:"calcium ion import") |
| pubmed:27794524 | p(HGNC:GZMB) increases bp(GO:"sodium ion import across plasma membrane") |
| pubmed:27794524 | p(HGNC:GZMB) increases bp(GO:"calcium ion import") |
| pubmed:27794524 | bp(GO:"glutamate homeostasis") negativeCorrelation p(HGNC:IFNG) |
| pubmed:27794524 | complex(p(HGNC:IFNG), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor AMPA type subunits")) regulates bp(GO:"calcium ion import") |
| pubmed:27794524 | bp(GO:"sodium ion import across plasma membrane") increases path(MESH:"Energy Metabolism") |
| pubmed:26979166 | bp(GO:"sodium ion import across plasma membrane") increases tloc(a(CHEBI:neurotransmitter), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27794524 | p(HGNC:FASLG) increases composite(a(MESH:"T-Lymphocytes, Cytotoxic"), p(HGNC:FAS)) |
| pubmed:27794524 | composite(a(MESH:"T-Lymphocytes, Cytotoxic"), p(HGNC:FAS)) increases act(a(MESH:Caspases)) |
| pubmed:19293145 | act(p(HGNC:FAS)) increases bp(GO:"programmed cell death") |
| pubmed:23702978 | act(p(HGNC:FAS)) increases act(p(HGNC:IL1B)) |
| pubmed:23702978 | act(p(HGNC:FAS)) increases act(p(HGNC:CASP8)) |
| pubmed:27794524 | act(a(MESH:Caspases)) increases path(MESH:"Nerve Degeneration") |
| pubmed:21214928 | a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) |
| pubmed:21214928 | a(MESH:Caspases) increases path(MESH:"Alzheimer Disease") |
| pubmed:21214928 | a(MESH:Caspases) increases rxn(reactants(p(CONSO:CONSO00071)), products(p(CONSO:CONSO00069), p(CONSO:CONSO00070))) |
| pubmed:21214928 | a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00069))) |
| pubmed:21214928 | a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00070))) |
| pubmed:22122372 | a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00069), p(CONSO:CONSO00070))) |
| pubmed:29215007 | a(MESH:Caspases) increases p(HGNC:MAPT, var("?")) |
| pubmed:27794524 | path(MESH:"Nerve Degeneration") association bp(GO:"microglial cell activation") |
| pubmed:27794524 | path(MESH:"Nerve Degeneration") association a(PUBCHEM:65065) |
| pubmed:18986241 | path(MESH:"Nerve Degeneration") association bp(MESH:"Oxidative Stress") |
| pubmed:30837838 | path(MESH:"Nerve Degeneration") association path(MESH:Transportation) |
| pubmed:30837838 | path(MESH:"Nerve Degeneration") association path(MESH:"Mitochondrial Size") |
| pubmed:30837838 | path(MESH:"Nerve Degeneration") association a(CHEBI:"calcium(2+)") |
| pubmed:30837838 | path(MESH:"Nerve Degeneration") association path(MESH:"Cell Respiration") |
| pubmed:30837838 | path(MESH:"Nerve Degeneration") association bp(GO:"ATP biosynthetic process") |
| pubmed:27794524 | a(MESH:Oligodendroglia) directlyDecreases a(CHEBI:"iron(3+)", loc(GO:"extracellular space")) |
| pubmed:27794524 | a(MESH:Oligodendroglia) directlyIncreases tloc(p(HGNC:GDNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27794524 | a(MESH:Oligodendroglia) directlyIncreases tloc(p(HGNC:IGF1), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27794524 | a(MESH:Oligodendroglia) directlyIncreases tloc(p(HGNC:BDNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27889190 | a(MESH:Oligodendroglia) increases p(HGNC:LINGO1) |
| pubmed:27889190 | a(MESH:Oligodendroglia) increases bp(MESH:Remyelination) |
| pubmed:30967783 | act(a(MESH:Oligodendroglia)) positiveCorrelation a(MESH:Astrocytes) |
| pubmed:30967783 | act(a(MESH:Oligodendroglia)) negativeCorrelation bp(GO:"neuroinflammatory response") |
| pubmed:21543606 | a(MESH:Oligodendroglia) decreases bp(GO:myelination) |
| pubmed:27794524 | act(a(MESH:Phagocytes)) directlyDecreases a(MESH:Oligodendroglia) |
| pubmed:30967783 | a(MESH:Phagocytes) increases bp(GO:"neuroinflammatory response") |
| pubmed:30967783 | a(MESH:Phagocytes) increases path(DOID:"multiple sclerosis") |
| pubmed:30967783 | a(MESH:Phagocytes) increases bp(MESH:Neuroprotection) |
| pubmed:30967783 | a(MESH:Phagocytes) decreases path(MESH:Inflammation) |
| pubmed:26979166 | act(a(MESH:Phagocytes)) increases a(MESH:"Reactive Oxygen Species") |
| pubmed:26979166 | act(a(MESH:Phagocytes)) increases a(MESH:"Reactive Nitrogen Species") |
| pubmed:27794524 | bp(GO:"regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II") positiveCorrelation bp(GO:"microglial cell activation") |
| pubmed:27794524 | bp(GO:"regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II") directlyDecreases a(MESH:Oligodendroglia) |
| pubmed:27794524 | path(MESH:"Mitochondrial Diseases") decreases path(MESH:"Energy Metabolism") |
| pubmed:27794524 | path(MESH:"Mitochondrial Diseases") decreases act(p(MESH:Mitochondria)) |
| pubmed:27794524 | path(MESH:"Mitochondrial Diseases") decreases act(p(MESH:"Electron Transport Chain Complex Proteins")) |
| pubmed:27956442 | path(MESH:"Mitochondrial Diseases") directlyIncreases path(MESH:Inflammation) |
| pubmed:27794524 | a(CHEBI:"reactive nitrogen species") directlyIncreases path(MESH:"Mitochondrial Diseases") |
| pubmed:27794524 | a(CHEBI:"reactive nitrogen species") isA a(MESH:Neurotoxins) |
| pubmed:16566606 | a(CHEBI:"reactive nitrogen species") decreases act(a(MESH:Neurons)) |
| pubmed:16566606 | a(CHEBI:"reactive nitrogen species") increases bp(GO:"neuron death") |
| pubmed:27794524 | a(CHEBI:laquinimod) decreases path(MESH:"Multiple Sclerosis") |
| pubmed:27794524 | a(CHEBI:laquinimod) association bp(GO:"central nervous system development") |
| pubmed:27794524 | a(CHEBI:laquinimod) decreases bp(GO:"astrocyte activation") |
| pubmed:27794524 | a(CHEBI:laquinimod) directlyDecreases bp(GO:"microglial cell activation") |
| pubmed:27794524 | a(CHEBI:laquinimod) decreases a(MESH:"Anti-Inflammatory Agents") |
| pubmed:27794524 | a(CHEBI:laquinimod) causesNoChange tloc(a(MESH:"Growth Differentiation Factors"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27794524 | a(CHEBI:laquinimod) decreases path(MESH:"Population Density") |
| pubmed:27794524 | a(CHEBI:laquinimod) decreases path(MESH:"Diffuse Axonal Injury") |
| pubmed:27794524 | a(CHEBI:laquinimod) decreases path(MESH:"Demyelinating Diseases") |
| pubmed:27794524 | bp(GO:"astrocyte activation") directlyDecreases path(MESH:Disease) |
| pubmed:27794524 | bp(GO:"astrocyte activation") increases p(HGNC:B4GALT6) |
| pubmed:27794524 | bp(GO:"astrocyte activation") directlyIncreases g(HGNC:CSF2) |
| pubmed:27794524 | bp(GO:"astrocyte activation") directlyIncreases g(HGNC:CCL2) |
| pubmed:29196815 | bp(GO:"astrocyte activation") positiveCorrelation a(CONSO:CONSO00074) |
| pubmed:27671637 | bp(GO:"astrocyte activation") negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pubmed:27314526 | bp(GO:"astrocyte activation") increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27314526 | bp(GO:"astrocyte activation") increases tloc(p(HGNC:IL6), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27314526 | bp(GO:"astrocyte activation") increases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27314526 | bp(GO:"astrocyte activation") increases tloc(p(HGNC:NOS2), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27956442 | path(MESH:"Diffuse Axonal Injury") increases path(MESH:"Neurodegenerative Diseases") |
| pubmed:28445721 | path(MESH:Disease) association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pubmed:27794524 | p(HGNC:B4GALT5) directlyIncreases path(MESH:Disease) |
| pubmed:27794524 | p(HGNC:B4GALT5) increases a(PUBCHEM:20057304) |
| pubmed:27794524 | p(HGNC:B4GALT6) directlyIncreases path(MESH:Disease) |
| pubmed:27794524 | p(HGNC:B4GALT6) increases a(PUBCHEM:20057304) |
| pubmed:27794524 | p(HGNC:B4GALT6) increases path(MESH:"Encephalomyelitis, Autoimmune, Experimental") |
| pubmed:27794524 | p(HGNC:B4GALT6) increases path(MESH:"Neurodegenerative Diseases") |
| pubmed:27794524 | a(PUBCHEM:20057304) directlyIncreases bp(GO:"astrocyte activation") |
| pubmed:27794524 | path(MESH:"Encephalomyelitis, Autoimmune, Experimental") directlyIncreases a(PUBCHEM:20057304) |
| pubmed:27794524 | g(HGNC:CSF2) increases bp(GO:"microglial cell activation") |
| pubmed:27794524 | g(HGNC:CCL2) increases bp(GO:"microglial cell activation") |
| pubmed:27794524 | a(MESH:Astrocytes) directlyIncreases a(CHEBI:"reactive oxygen species") |
| pubmed:27794524 | a(MESH:Astrocytes) directlyIncreases a(CHEBI:"reactive nitrogen species") |
| pubmed:27794524 | a(MESH:Astrocytes) directlyIncreases a(CHEBI:"nitric oxide") |
| pubmed:27794524 | a(MESH:Astrocytes) association a(PUBCHEM:54677946) |
| pubmed:30967783 | act(a(MESH:Astrocytes)) negativeCorrelation p(HGNC:TNF) |
| pubmed:30967783 | act(a(MESH:Astrocytes)) negativeCorrelation p(HGNC:C1QA) |
| pubmed:30967783 | a(MESH:Astrocytes) positiveCorrelation act(a(MESH:Neurons)) |
| pubmed:30967783 | a(MESH:Astrocytes) positiveCorrelation act(a(MESH:Oligodendroglia)) |
| pubmed:19126755 | a(MESH:Astrocytes) increases a(CHEBI:"kynurenic acid") |
| pubmed:23383175 | a(MESH:Astrocytes) positiveCorrelation a(MESH:Microglia) |
| pubmed:23383175 | a(MESH:Astrocytes) negativeCorrelation a(GO:"myelin sheath") |
| pubmed:30108137 | a(MESH:Astrocytes) increases act(a(MESH:Lysosomes)) |
| pubmed:28803412 | a(MESH:Astrocytes) increases deg(a(CONSO:CONSO00093)) |
| pubmed:30108137 | act(a(MESH:Astrocytes)) increases tloc(a(CONSO:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:26195256 | a(MESH:Astrocytes) increases tloc(p(MESH:Endopeptidases), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:26195256 | a(MESH:Astrocytes) decreases a(CHEBI:amyloid-beta, loc(MESH:"Extracellular Fluid")) |
| pubmed:26195256 | a(MESH:Astrocytes) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:26195256 | act(a(MESH:Astrocytes)) decreases a(CHEBI:amyloid-beta) |
| pubmed:26195256 | act(a(MESH:Astrocytes)) increases a(MESH:Cytokines) |
| pubmed:18562203 | act(a(MESH:Astrocytes)) association p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) |
| pubmed:18562203 | act(a(MESH:Astrocytes)) association path(MESH:"Plaque, Amyloid") |
| pubmed:27314526 | a(MESH:Astrocytes) increases p(HGNC:NLRP3) |
| pubmed:27314526 | a(MESH:Astrocytes) increases p(HGNC:TLR4) |
| pubmed:27314526 | a(MESH:Astrocytes) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27794524 | a(MESH:"Free Radical Scavengers") directlyDecreases a(CHEBI:"reactive oxygen species") |
| pubmed:27794524 | a(MESH:"Free Radical Scavengers") directlyDecreases a(CHEBI:"reactive nitrogen species") |
| pubmed:27794524 | a(MESH:"Free Radical Scavengers") causesNoChange path(MESH:Immunity) |
| pubmed:27794524 | act(p(MESH:"Electron Transport Chain Complex Proteins")) directlyDecreases tloc(a(CHEBI:"reactive oxygen species"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27794524 | p(MESH:"Molecular Motor Proteins") directlyIncreases tloc(p(MESH:Mitochondria), fromLoc(GO:"cell body"), toLoc(GO:axon)) |
| pubmed:27794524 | a(CHEBI:"iron(3+)", loc(GO:"extracellular space")) increases a(CHEBI:"iron(2+)", loc(GO:"extracellular space")) |
| pubmed:30837838 | a(CHEBI:"iron(3+)") association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | a(CHEBI:"iron(3+)") causesNoChange a(MESH:"Inclusion Bodies") |
| pubmed:30837838 | a(CHEBI:"iron(3+)") causesNoChange path(MESH:"Protein Aggregation, Pathological") |
| pubmed:27794524 | a(CHEBI:"iron(2+)", loc(GO:"extracellular space")) directlyIncreases a(CHEBI:"reactive oxygen species") |
| pubmed:27794524 | a(CHEBI:"sodium(1+)", loc(GO:axon)) directlyIncreases a(CHEBI:"calcium(2+)", loc(GO:axon)) |
| pubmed:30837838 | a(CHEBI:"sodium(1+)") increases bp(GO:"neuron death") |
| pubmed:27794524 | p(MESH:"Sodium-Calcium Exchanger") directlyDecreases a(CHEBI:"calcium(2+)", loc(GO:axon)) |
| pubmed:27794524 | p(MESH:"Sodium-Calcium Exchanger") directlyDecreases a(CHEBI:"calcium(2+)", loc(GO:"extracellular space")) |
| pubmed:27794524 | p(MESH:"Sodium-Calcium Exchanger") directlyIncreases a(CHEBI:"sodium(1+)", loc(GO:axon)) |
| pubmed:27794524 | a(MESH:Calpain) directlyIncreases path(MESH:"Nerve Degeneration") |
| pubmed:27794524 | a(MESH:Calpain) directlyIncreases deg(p(MESH:"Cytoskeletal Proteins")) |
| pubmed:27794524 | a(MESH:Phospholipases) directlyIncreases path(MESH:"Nerve Degeneration") |
| pubmed:27794524 | a(MESH:Phospholipases) directlyIncreases deg(p(MESH:"Cytoskeletal Proteins")) |
| pubmed:23038257 | p(MESH:"Cytoskeletal Proteins") association p(HGNC:CHRNA4) |
| pubmed:29428175 | p(MESH:"Cytoskeletal Proteins") regulates bp(GO:"vesicle-mediated transport") |
| pubmed:27794524 | p(MESH:"Microtubule Proteins", pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation a(CHEBI:"calcium(2+)", loc(GO:axon)) |
| pubmed:27794524 | p(MESH:"Microtubule Proteins", pmod(go:0006468 ! "protein phosphorylation")) regulates path(MESH:Cytoskeleton) |
| pubmed:27794524 | p(MESH:"Neurofilament Proteins", pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation a(CHEBI:"calcium(2+)", loc(GO:axon)) |
| pubmed:27794524 | p(MESH:"Neurofilament Proteins", pmod(go:0006468 ! "protein phosphorylation")) regulates path(MESH:Cytoskeleton) |
| pubmed:28148553 | p(MESH:"Neurofilament Proteins", pmod(go:0006468 ! "protein phosphorylation"), loc(MESH:Axons)) association act(a(MESH:Axons)) |
| pubmed:28148553 | p(MESH:"Neurofilament Proteins", pmod(go:0006468 ! "protein phosphorylation")) association path(DOID:tauopathy) |
| pubmed:27794524 | p(MESH:"Sodium-Potassium-Exchanging ATPase") regulates bp(GO:"membrane repolarization") |
| pubmed:27794524 | p(HGNC:TRPM4) decreases bp(GO:"positive regulation of calcium ion import") |
| pubmed:27794524 | bp(GO:"positive regulation of calcium ion import") increases path(CONSO:Excitotoxicity) |
| pubmed:27794524 | p(MESH:"Calcium Channels") decreases bp(GO:"positive regulation of calcium ion import") |
| pubmed:27794524 | p(HGNC:ASIC1) decreases bp(GO:"positive regulation of calcium ion import") |
| pubmed:27794524 | act(p(MESH:"Receptors, Glutamate")) increases path(CONSO:Excitotoxicity) |
| pubmed:29428175 | p(MESH:"Receptors, Glutamate", loc(GO:"postsynaptic membrane")) association bp(MESH:"Neuronal Plasticity") |
| pubmed:29428175 | p(MESH:"Receptors, Glutamate", loc(GO:"postsynaptic membrane")) association bp(GO:"synaptic transmission, GABAergic") |
| pubmed:27794524 | p(MESH:"Gonadal Steroid Hormones") directlyDecreases path(MESH:Atrophy) |
| pubmed:27794524 | p(MESH:Testosterone) directlyIncreases path(CONSO:Excitotoxicity) |
| pubmed:27794524 | p(MESH:Testosterone) decreases path(MESH:Remyelination) |
| pubmed:27794524 | a(PUBCHEM:65065) association path(MESH:"Nerve Degeneration") |
| pubmed:27794524 | a(PUBCHEM:4212) decreases path(MESH:"Multiple Sclerosis") |
| pubmed:27794524 | a(PUBCHEM:4212) increases path(MESH:Cardiomyopathies) |
| pubmed:27794524 | a(PUBCHEM:4212) increases path(MESH:"Leukemia, Promyelocytic, Acute") |
| pubmed:27956442 | a(PUBCHEM:4212) directlyDecreases path(MESH:"Multiple Sclerosis, Chronic Progressive") |
| pubmed:27956442 | a(PUBCHEM:4212) increases path(MESH:"Arrhythmias, Cardiac") |
| pubmed:27956442 | a(PUBCHEM:4212) increases path(MESH:"Leukemia, Myeloid, Acute") |
| pubmed:27794524 | a(PUBCHEM:363907627) decreases path(MESH:"Developmental Disabilities") |
| pubmed:27794524 | a(PUBCHEM:363907627) directlyDecreases path(MESH:"Multiple Sclerosis, Relapsing-Remitting") |
| pubmed:27794524 | a(PUBCHEM:47206937) directlyIncreases bp(GO:"antibody-dependent cellular cytotoxicity") |
| pubmed:27794524 | a(PUBCHEM:47206937) decreases path(MESH:"Multiple Sclerosis, Chronic Progressive") |
| pubmed:27956442 | a(PUBCHEM:47206937) decreases path(MESH:"Multiple Sclerosis, Chronic Progressive") |
| pubmed:27956442 | a(PUBCHEM:47206937) directlyDecreases p(HGNC:MS4A1) |
| pubmed:27794524 | bp(GO:"antibody-dependent cellular cytotoxicity") decreases a(MESH:B-Lymphocytes) |
| pubmed:27794524 | a(PUBCHEM:11388331) directlyDecreases a(CHEBI:"reactive oxygen species", loc(GO:mitochondrion)) |
| pubmed:27794524 | a(PUBCHEM:11388331) causesNoChange path(MESH:Inflammation) |
| pubmed:27794524 | a(PUBCHEM:11388331) directlyDecreases path(MESH:"Nerve Degeneration") |
| pubmed:27794524 | a(PUBCHEM:3686) isA a(MESH:Antioxidants) |
| pubmed:27794524 | a(PUBCHEM:3686) directlyDecreases path(MESH:"Optic Atrophy, Hereditary, Leber") |
| pubmed:27794524 | a(PUBCHEM:3686) causesNoChange path(MESH:"Encephalomyelitis, Autoimmune, Experimental") |
| pubmed:27794524 | a(PUBCHEM:3878) decreases path(MESH:"Neurologic Manifestations") |
| pubmed:27794524 | a(PUBCHEM:3878) causesNoChange path(MESH:"Multiple Sclerosis") |
| pubmed:27794524 | a(PUBCHEM:1775) decreases path(MESH:"Neurologic Manifestations") |
| pubmed:27794524 | a(PUBCHEM:2554) decreases path(MESH:"Neurologic Manifestations") |
| pubmed:27794524 | a(PUBCHEM:16231) directlyDecreases p(HGNC:ASIC1) |
| pubmed:27794524 | a(PUBCHEM:16231) directlyDecreases p(HGNC:TRPM4) |
| pubmed:27794524 | a(PUBCHEM:16231) increases path(MESH:Neuroprotection) |
| pubmed:27794524 | a(PUBCHEM:16231) increases a(MESH:Oligodendroglia) |
| pubmed:27794524 | a(PUBCHEM:16231) decreases path(MESH:"Nerve Degeneration") |
| pubmed:27794524 | a(PUBCHEM:3488) directlyDecreases p(HGNC:ASIC1) |
| pubmed:27794524 | a(PUBCHEM:3488) directlyDecreases p(HGNC:TRPM4) |
| pubmed:27794524 | a(PUBCHEM:3488) increases path(MESH:Neuroprotection) |
| pubmed:27794524 | a(PUBCHEM:3488) increases a(MESH:Oligodendroglia) |
| pubmed:27794524 | a(PUBCHEM:3488) decreases path(MESH:"Nerve Degeneration") |
| pubmed:27794524 | a(PUBCHEM:3272524) decreases path(MESH:"Nerve Degeneration") |
| pubmed:27794524 | a(PUBCHEM:3272524) increases a(MESH:Oligodendroglia) |
| pubmed:27794524 | a(PUBCHEM:3272524) decreases deg(a(MESH:Axons)) |
| pubmed:22372633 | a(MESH:Axons) negativeCorrelation path(MESH:"Muscle Denervation") |
| pubmed:12428809 | a(MESH:Axons) negativeCorrelation a(MESH:"Intermediate Filaments") |
| pubmed:28148553 | act(a(MESH:Axons)) association p(MESH:"Neurofilament Proteins", pmod(go:0006468 ! "protein phosphorylation"), loc(MESH:Axons)) |
| pubmed:27671637 | a(MESH:Axons) positiveCorrelation p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pubmed:27794524 | p(HGNC:GDNF) association bp(GO:"axon development") |
| pubmed:27794524 | bp(GO:"axon development") association p(HGNC:GDNF) |
| pubmed:27794524 | bp(GO:"axon development") association p(HGNC:IGF1) |
| pubmed:27794524 | bp(GO:"axon development") association p(HGNC:BDNF) |
| pubmed:30061532 | bp(GO:"axon development") association p(HGNC:DISC1) |
| pubmed:30061532 | bp(GO:"axon development") association p(HGNC:DPYSL2) |
| pubmed:27794524 | a(PUBCHEM:54677946) isA a(MESH:"Neuroprotective Agents") |
| pubmed:27794524 | a(PUBCHEM:54677946) association a(MESH:Microglia) |
| pubmed:27794524 | a(PUBCHEM:54677946) association a(MESH:Astrocytes) |
| pubmed:30740335 | a(MESH:"Neuroprotective Agents") association a(PUBCHEM:9561611) |
| pubmed:27794524 | a(PUBCHEM:3671) directlyIncreases a(MESH:"Nerve Growth Factors") |
| pubmed:27794524 | a(PUBCHEM:3671) directlyDecreases bp(GO:"glial cell activation") |
| pubmed:27794524 | bp(GO:"myelin maintenance") negativeCorrelation path(MESH:"Oxidative Stress") |
| pubmed:27794524 | a(PUBCHEM:10074640) directlyDecreases p(MESH:"Receptor Protein-Tyrosine Kinases") |
| pubmed:27794524 | a(PUBCHEM:10074640) regulates bp(GO:"mast cell degranulation") |
| pubmed:27794524 | a(PUBCHEM:10074640) regulates bp(GO:"nitric oxide mediated signal transduction") |
| pubmed:27794524 | a(PUBCHEM:10074640) regulates bp(GO:"dendritic cell homeostasis") |
| pubmed:27794524 | p(HGNC:LINGO1) directlyDecreases bp(GO:"oligodendrocyte differentiation") |
| pubmed:27794524 | p(HGNC:LINGO1) directlyDecreases bp(GO:myelination) |
| pubmed:27794524 | p(HGNC:LINGO1) positiveCorrelation path(MESH:"Multiple Sclerosis") |
| pubmed:27794524 | a(PUBCHEM:310264704) directlyDecreases p(HGNC:LINGO1) |
| pubmed:27956442 | a(MESH:"Motor Neurons") association path(MESH:"Multiple Sclerosis") |
| pubmed:30688256 | a(MESH:"Motor Neurons") decreases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:28148553 | a(MESH:"Motor Neurons") negativeCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) |
| pubmed:27956442 | path(MESH:Sensation) association path(MESH:"Multiple Sclerosis") |
| pubmed:27956442 | path(MESH:"Autonomic Nervous System") association path(MESH:"Multiple Sclerosis") |
| pubmed:27956442 | path(MESH:"Optic Neuritis") association path(MESH:"Multiple Sclerosis") |
| pubmed:27956442 | path(MESH:"Body Temperature Changes") association path(MESH:"Multiple Sclerosis") |
| pubmed:27956442 | path(NCIT:C28314) association path(MESH:"Multiple Sclerosis") |
| pubmed:27956442 | path(MESH:"Central Nervous System") negativeCorrelation path(MESH:"Demyelinating Diseases") |
| pubmed:27956442 | bp(GO:"transport across blood-brain barrier") directlyIncreases path(NCIT:C20613) |
| pubmed:27956442 | bp(GO:"transport across blood-brain barrier") directlyIncreases bp(GO:"microglial cell activation") |
| pubmed:27956442 | bp(GO:"transport across blood-brain barrier") directlyIncreases path(MESH:"Oxidative Stress") |
| pubmed:27956442 | bp(GO:"transport across blood-brain barrier") directlyIncreases path(MESH:"Mitochondrial Diseases") |
| pubmed:27956442 | bp(GO:"transport across blood-brain barrier") negativeCorrelation path(MESH:"Energy Metabolism") |
| pubmed:27956442 | path(NCIT:C20613) directlyIncreases path(MESH:Inflammation) |
| pubmed:27956442 | path(MESH:"Spinal Cord Diseases") increases path(EFO:"movement disorder") |
| pubmed:27956442 | path(MESH:"Spinal Cord Diseases") directlyIncreases path(MESH:"Paraparesis, Spastic") |
| pubmed:27956442 | path(MESH:"Paraparesis, Spastic") directlyIncreases path(MESH:"Diffuse Axonal Injury") |
| pubmed:27956442 | path(MESH:"Infectious Mononucleosis") positiveCorrelation path(MESH:"Multiple Sclerosis") |
| pubmed:27956442 | a(CHEBI:6-methylprednisolone) directlyDecreases path(MESH:"Multiple Sclerosis, Relapsing-Remitting") |
| pubmed:27956442 | path(MESH:"Plasma Exchange") directlyDecreases path(MESH:"Multiple Sclerosis, Relapsing-Remitting") |
| pubmed:27956442 | path(MESH:"Physical Therapy Modalities") decreases path(MESH:"Multiple Sclerosis, Relapsing-Remitting") |
| pubmed:26445701 | a(MESH:"Cell Adhesion Molecules") increases bp(MESH:"Transendothelial and Transepithelial Migration") |
| pubmed:27956442 | path(MESH:"JC Virus") increases path(MESH:"Leukoencephalopathy, Progressive Multifocal") |
| pubmed:27956442 | a(PUBCHEM:2265) causesNoChange path(MESH:"Multiple Sclerosis, Chronic Progressive") |
| pubmed:27956442 | a(PUBCHEM:5284373) causesNoChange path(MESH:"Multiple Sclerosis, Chronic Progressive") |
| pubmed:27956442 | a(PUBCHEM:44151255) causesNoChange path(MESH:"Multiple Sclerosis, Chronic Progressive") |
| pubmed:27956442 | a(MESH:Immunoglobulins) causesNoChange path(MESH:"Multiple Sclerosis, Chronic Progressive") |
| pubmed:27956442 | a(PUBCHEM:20279) causesNoChange path(MESH:"Multiple Sclerosis, Chronic Progressive") |
| pubmed:27956442 | a(MESH:"Immunologic Factors") causesNoChange path(MESH:"Multiple Sclerosis, Chronic Progressive") |
| pubmed:27956442 | a(PUBCHEM:44599207) regulates p(HGNCGENEFAMILY:"Sphingosine 1-phosphate receptors") |
| pubmed:27956442 | a(PUBCHEM:44599207) decreases path(MESH:"Multiple Sclerosis, Chronic Progressive") |
| pubmed:27956442 | a(PUBCHEM:47206399) increases path(MESH:Headache) |
| pubmed:27956442 | a(PUBCHEM:47206399) increases path(MESH:Lymphopenia) |
| pubmed:27956442 | a(PUBCHEM:47206399) increases path(MESH:"Sleep Initiation and Maintenance Disorders") |
| pubmed:27956442 | a(PUBCHEM:47206399) increases path(MESH:Diarrhea) |
| pubmed:27956442 | a(PUBCHEM:47206399) increases path(MESH:Nausea) |
| pubmed:27956442 | a(PUBCHEM:47206399) increases path(MESH:Vomiting) |
| pubmed:27956442 | a(PUBCHEM:47206399) increases path(MESH:Depression) |
| pubmed:27956442 | a(PUBCHEM:47206399) increases path(MESH:Alopecia) |
| pubmed:27956442 | a(PUBCHEM:47206399) increases path(MESH:"Thyroid Diseases") |
| pubmed:18986241 | path(MESH:"Sleep Initiation and Maintenance Disorders") association a(MESH:"Cholinesterase Inhibitors") |
| pubmed:26195256 | path(MESH:"Sleep Initiation and Maintenance Disorders") increases path(MESH:"Alzheimer Disease") |
| pubmed:26195256 | path(MESH:"Sleep Initiation and Maintenance Disorders") increases path(MESH:"Alzheimer Disease") |
| pubmed:19721446 | path(MESH:Vomiting) association a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") |
| pubmed:27956442 | a(PUBCHEM:172232576) increases path(MESH:Headache) |
| pubmed:27956442 | a(PUBCHEM:172232576) increases path(MESH:Lymphopenia) |
| pubmed:27956442 | a(PUBCHEM:172232576) increases path(MESH:"Sleep Initiation and Maintenance Disorders") |
| pubmed:27956442 | a(PUBCHEM:172232576) increases path(MESH:Diarrhea) |
| pubmed:27956442 | a(PUBCHEM:172232576) increases path(MESH:Nausea) |
| pubmed:27956442 | a(PUBCHEM:172232576) increases path(MESH:Vomiting) |
| pubmed:27956442 | a(PUBCHEM:172232576) increases path(MESH:Depression) |
| pubmed:27956442 | a(PUBCHEM:172232576) increases path(MESH:Alopecia) |
| pubmed:27956442 | a(PUBCHEM:172232576) increases path(MESH:"Liver Diseases") |
| pubmed:27956442 | a(PUBCHEM:172232576) increases path(MESH:"Thyroid Diseases") |
| pubmed:27181519 | path(MESH:"Liver Diseases") association p(HGNC:TBK1) |
| pubmed:27956442 | a(PUBCHEM:50070200) increases path(MESH:Headache) |
| pubmed:27956442 | a(PUBCHEM:50070200) increases path(MESH:Lymphopenia) |
| pubmed:27956442 | a(PUBCHEM:50070200) increases path(MESH:"Sleep Initiation and Maintenance Disorders") |
| pubmed:27956442 | a(PUBCHEM:50070200) increases path(MESH:Diarrhea) |
| pubmed:27956442 | a(PUBCHEM:50070200) increases path(MESH:Nausea) |
| pubmed:27956442 | a(PUBCHEM:50070200) increases path(MESH:Vomiting) |
| pubmed:27956442 | a(PUBCHEM:50070200) increases path(MESH:Depression) |
| pubmed:27956442 | a(PUBCHEM:50070200) increases path(MESH:Alopecia) |
| pubmed:27956442 | a(PUBCHEM:50070200) increases path(MESH:"Liver Diseases") |
| pubmed:27956442 | a(PUBCHEM:50070200) increases path(MESH:"Thyroid Diseases") |
| pubmed:27956442 | a(PUBCHEM:50070200) increases path(HP:Lipoatrophy) |
| pubmed:27956442 | a(PUBCHEM:50070200) increases path(MESH:Anxiety) |
| pubmed:27956442 | a(PUBCHEM:50070200) increases path(MESH:Flushing) |
| pubmed:27956442 | a(PUBCHEM:50070200) increases path(HP:Palpitations) |
| pubmed:27956442 | a(PUBCHEM:50070200) increases path(MESH:Dyspnea) |
| pubmed:27956442 | a(PUBCHEM:50070200) increases path(MESH:"Chest Pain") |
| pubmed:26445701 | g(HGNC:IL2RA) positiveCorrelation path(DOID:"multiple sclerosis") |
| pubmed:26445701 | g(HGNC:IL7R) positiveCorrelation path(DOID:"multiple sclerosis") |
| pubmed:26445701 | path(MESH:"Vitamin D Deficiency") positiveCorrelation path(DOID:"multiple sclerosis") |
| pubmed:26445701 | act(a(MESH:"Th1 Cells")) increases path(MESH:"Autoimmune Diseases") |
| pubmed:26445701 | a(MESH:"Th1 Cells") increases p(HGNC:IL2) |
| pubmed:26445701 | a(MESH:"Th1 Cells") increases p(HGNC:TNF) |
| pubmed:26445701 | a(MESH:"Th1 Cells") increases p(MESH:Interferon-gamma) |
| pubmed:26445701 | a(MESH:"Th1 Cells") association a(MESH:"Th17 Cells") |
| pubmed:30967783 | a(MESH:"Th1 Cells") increases p(HGNC:IFNG) |
| pubmed:26445701 | a(MESH:Sanitation) increases path(MESH:"Autoimmune Diseases") |
| pubmed:26445701 | a(MESH:Sanitation) increases path(HP:Allergy) |
| pubmed:26445701 | act(a(MESH:"Th2 Cells")) increases path(HP:Allergy) |
| pubmed:26445701 | a(MESH:"Th2 Cells") increases tloc(p(HGNC:IL4), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:26979166 | a(MESH:"Th2 Cells") increases tloc(p(HGNC:IL4), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30988501 | a(MESH:"Th2 Cells") increases act(p(HGNC:IL4)) |
| pubmed:26445701 | a(MESH:"Th2 Cells") increases tloc(p(HGNC:IL5), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:26979166 | a(MESH:"Th2 Cells") increases tloc(p(HGNC:IL5), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:26445701 | a(MESH:"Th2 Cells") increases tloc(p(HGNC:IL10), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:26445701 | a(MESH:"Th2 Cells") decreases act(a(MESH:"Th1 Cells")) |
| pubmed:30967783 | a(MESH:"Th2 Cells") association a(NCIT:C123783) |
| pubmed:30988501 | a(MESH:"Th2 Cells") association path(MESH:"Brain Injuries") |
| pubmed:26445701 | a(CHEBI:"vitamin A") regulates bp(MESH:Immunity) |
| pubmed:27190210 | bp(MESH:Immunity) association p(HGNC:CHRNA7) |
| pubmed:26445701 | a(CHEBI:salt) regulates bp(MESH:Immunity) |
| pubmed:26445701 | a(CHEBI:salt) regulates bp(GO:"T-helper 17 cell differentiation") |
| pubmed:26445701 | a(CHEBI:"omega-3 unsaturated fatty acyl-CoA(4-)") regulates bp(MESH:Immunity) |
| pubmed:26445701 | a(CHEBI:polyphenol) regulates bp(MESH:Immunity) |
| pubmed:21882945 | a(CHEBI:polyphenol) decreases a(CONSO:"Tau aggregates") |
| pubmed:21882945 | a(CHEBI:polyphenol) decreases complex(p(INTERPRO:"Chaperone J-domain superfamily"), p(INTERPRO:"Heat shock protein 70 family")) |
| pubmed:26445701 | a(CHEBI:"sodium salt") increases path(EFO:"experimental autoimmune encephalomyelitis") |
| pubmed:26445701 | a(CHEBI:"sodium salt") increases path(DOID:"multiple sclerosis") |
| pubmed:26445701 | act(a(MESH:"CD4-Positive T-Lymphocytes")) increases deg(a(GO:"myelin sheath")) |
| pubmed:26445701 | a(MESH:"CD4-Positive T-Lymphocytes") increases path(HP:"CNS demyelination") |
| pubmed:26445701 | a(MESH:"CD4-Positive T-Lymphocytes") increases path(MESH:"Diffuse Axonal Injury") |
| pubmed:26445701 | a(MESH:"CD4-Positive T-Lymphocytes") increases bp(GO:"positive regulation of oligodendrocyte apoptotic process") |
| pubmed:26445701 | deg(a(GO:"myelin sheath")) increases bp(MESH:"Self Tolerance") |
| pubmed:23383175 | a(GO:"myelin sheath") positiveCorrelation a(CHEBI:Anatabine) |
| pubmed:23383175 | a(GO:"myelin sheath") negativeCorrelation a(MESH:Astrocytes) |
| pubmed:23383175 | a(GO:"myelin sheath") negativeCorrelation a(MESH:Microglia) |
| pubmed:23383175 | a(GO:"myelin sheath") negativeCorrelation bp(CONSO:Astrogliosis) |
| pubmed:23383175 | a(GO:"myelin sheath") negativeCorrelation bp(CONSO:Microgliosis) |
| pubmed:26445701 | bp(MESH:"Self Tolerance") increases path(MESH:Autoimmunity) |
| pubmed:26445701 | bp(MESH:"Self Tolerance") increases act(a(MESH:T-Lymphocytes)) |
| pubmed:26445701 | path(HP:"Disseminated viral infection") increases bp(GO:"T cell activation") |
| pubmed:26445701 | path(HP:"Disseminated viral infection") increases a(MESH:Autoantigens) |
| pubmed:30967783 | bp(GO:"T cell activation") increases bp(GO:"microglial cell activation") |
| pubmed:30967783 | bp(GO:"T cell activation") increases path(CONSO:neuroinflammation) |
| pubmed:26445701 | bp(MESH:"Molecular Mimicry") increases a(MESH:Autoantigens) |
| pubmed:26445701 | bp(MESH:"Molecular Mimicry") increases bp(GO:"T cell activation") |
| pubmed:30988501 | bp(MESH:"Molecular Mimicry") increases bp(GO:"activation of immune response") |
| pubmed:30988501 | bp(MESH:"Molecular Mimicry") increases path(MESH:"Autoimmune Diseases") |
| pubmed:26445701 | a(MESH:"Th17 Cells") association a(MESH:"Th1 Cells") |
| pubmed:26445701 | a(MESH:"Th17 Cells") increases tloc(p(HGNC:IL17A), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30988501 | a(MESH:"Th17 Cells", loc(MESH:"Central Nervous System")) increases bp(MESH:"Immunity, Cellular") |
| pubmed:30988501 | a(MESH:"Th17 Cells") increases path(HP:Autism) |
| pubmed:30967783 | p(HGNC:IL4) increases act(a(NCIT:C123783)) |
| pubmed:30967783 | p(HGNC:IL4) decreases bp(GO:"inflammatory response") |
| pubmed:30967783 | p(HGNC:IL4) decreases bp(GO:"inflammatory response") |
| pubmed:30967783 | p(HGNC:IL4) increases bp(GO:"oligodendrocyte development") |
| pubmed:30967783 | p(HGNC:IL4) increases bp(MESH:Remyelination) |
| pubmed:26979166 | p(HGNC:IL4) increases bp(GO:"mast cell activation") |
| pubmed:31413141 | p(HGNC:IL4) increases bp(GO:"macrophage activation") |
| pubmed:31413141 | p(HGNC:IL4) increases bp(GO:"macrophage activation") |
| pubmed:26979166 | p(HGNC:IL5) increases bp(GO:"mast cell activation") |
| pubmed:30935091 | path(DOID:"axonal neuropathy") decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:26445701 | bp(GO:"complement activation") increases path(HP:"CNS demyelination") |
| pubmed:26445701 | bp(GO:"complement activation") increases path(MESH:"Diffuse Axonal Injury") |
| pubmed:26445701 | bp(GO:"complement activation") increases bp(GO:"positive regulation of oligodendrocyte apoptotic process") |
| pubmed:30967783 | bp(GO:"complement activation") increases bp(NCIT:C53611) |
| pubmed:" 26517285" | bp(GO:"complement activation") association g(DBSNP:rs3824968) |
| pubmed:26445701 | a(HP:"Senile plaques") increases path(MESH:Inflammation) |
| pubmed:26445701 | a(HP:"Senile plaques") increases path(HP:"Axonal loss") |
| pubmed:26445701 | a(HP:"Focal white matter lesions") increases path(MESH:Inflammation) |
| pubmed:26445701 | a(HP:"Focal white matter lesions") decreases bp(GO:cognition) |
| pubmed:26445701 | bp(GO:"sensory perception") association path(DOID:"multiple sclerosis") |
| pubmed:30012004 | bp(GO:"sensory perception") negativeCorrelation path(MESH:"Huntington Disease") |
| pubmed:26445701 | bp(GO:"motor behavior") association path(DOID:"multiple sclerosis") |
| pubmed:30515821 | bp(GO:"motor behavior") positiveCorrelation p(HGNC:DNM1) |
| pubmed:30012004 | bp(GO:"motor behavior") negativeCorrelation path(MESH:"Huntington Disease") |
| pubmed:30985105 | bp(GO:"motor behavior") negativeCorrelation deg(a(CONSO:"Dopaminergic cell groups")) |
| pubmed:30985105 | bp(GO:"motor behavior") decreases path(MESH:Hypokinesia) |
| pubmed:30985105 | bp(GO:"motor behavior") decreases path(MESH:"Muscle Rigidity") |
| pubmed:30985105 | bp(GO:"motor behavior") decreases path(HP:"Postural instability") |
| pubmed:26445701 | bp(GO:"visual behavior") association path(DOID:"multiple sclerosis") |
| pubmed:30988501 | path(HP:Fatigue) increases bp(MESH:Survival) |
| pubmed:26445701 | a(DRUGBANK:Methylprednisolone) decreases path(DOID:"relapsing-remitting multiple sclerosis") |
| pubmed:26445701 | a(DRUGBANK:Methylprednisolone) decreases path(MESH:Inflammation) |
| pubmed:26445701 | a(DRUGBANK:Methylprednisolone) isA a(CHEBI:immunomodulator) |
| pubmed:26445701 | a(MESH:"Adrenocorticotropic Hormone") decreases path(DOID:"relapsing-remitting multiple sclerosis") |
| pubmed:26445701 | a(MESH:"Adrenocorticotropic Hormone") decreases path(MESH:Inflammation) |
| pubmed:26445701 | a(MESH:"Adrenocorticotropic Hormone") isA a(CHEBI:immunomodulator) |
| pubmed:26445701 | p(HGNCGENEFAMILY:Interferons) isA a(CHEBI:"antiviral agent") |
| pubmed:26445701 | p(HGNCGENEFAMILY:Interferons) isA a(CHEBI:"antibacterial agent") |
| pubmed:26445701 | p(HGNCGENEFAMILY:Interferons) decreases path(DOID:"multiple sclerosis") |
| pubmed:26445701 | a(MESH:"Blood-Brain Barrier") association p(HGNC:IFNB1) |
| pubmed:26195256 | a(MESH:"Blood-Brain Barrier") decreases a(CHEBI:amyloid-beta, loc(GO:"extracellular region")) |
| pubmed:30988501 | deg(a(MESH:"Blood-Brain Barrier")) decreases p(HGNC:CLDN5) |
| pubmed:26445701 | bp(GO:"T-helper 2 cell cytokine production") decreases path(MESH:Inflammation) |
| pubmed:26445701 | complex(a(DRUGBANK:Natalizumab), p(HGNC:ITGA4), p(HGNC:ITGB1)) decreases complex(p(HGNC:ITGA4), p(HGNC:ITGB1), p(HGNC:VCAM1)) |
| pubmed:26445701 | complex(a(DRUGBANK:Natalizumab), p(HGNC:ITGA4), p(HGNC:ITGB1)) decreases bp(MESH:"Transendothelial and Transepithelial Migration") |
| pubmed:26445701 | complex(p(HGNC:ITGA4), p(HGNC:ITGB1), p(HGNC:VCAM1)) increases bp(MESH:"Transendothelial and Transepithelial Migration") |
| pubmed:26445701 | a(MESH:"JC Virus") increases path(DOID:"progressive multifocal leukoencephalopathy") |
| pubmed:26445701 | a(CHEBI:mitoxantrone) isA a(CHEBI:"antineoplastic agent") |
| pubmed:26445701 | a(CHEBI:mitoxantrone) decreases a(MESH:B-Lymphocytes) |
| pubmed:26445701 | a(CHEBI:mitoxantrone) decreases a(MESH:T-Lymphocytes) |
| pubmed:26445701 | a(CHEBI:mitoxantrone) decreases bp(GO:"macrophage proliferation") |
| pubmed:26445701 | a(CHEBI:mitoxantrone) decreases path(DOID:"relapsing-remitting multiple sclerosis") |
| pubmed:26445701 | a(CHEBI:mitoxantrone) decreases path(DOID:"secondary progressive multiple sclerosis") |
| pubmed:26445701 | a(CHEBI:mitoxantrone) increases path(MESH:Cardiotoxicity) |
| pubmed:26445701 | a(CHEBI:mitoxantrone) increases path(DOID:leukemia) |
| pubmed:26445701 | a(CHEBI:fingolimod) decreases path(DOID:"relapsing-remitting multiple sclerosis") |
| pubmed:26445701 | a(CHEBI:fingolimod) regulates p(HGNC:S1PR1) |
| pubmed:26445701 | a(CHEBI:fingolimod) decreases path(DOID:"multiple sclerosis") |
| pubmed:26445701 | a(CHEBI:fingolimod) increases path(HP:Bradycardia) |
| pubmed:26445701 | a(CHEBI:fingolimod) increases path(DOID:"atrioventricular block") |
| pubmed:26445701 | a(CHEBI:fingolimod) increases path(DOID:"herpes simplex") |
| pubmed:26445701 | a(CHEBI:fingolimod) increases path(HP:"Macular edema") |
| pubmed:26445701 | a(CHEBI:fingolimod) increases bp(GO:"positive regulation of blood pressure") |
| pubmed:26445701 | a(CHEBI:fingolimod) increases path(DOID:"progressive multifocal leukoencephalopathy") |
| pubmed:26445701 | a(CHEBI:teriflunomide) decreases path(DOID:"relapsing-remitting multiple sclerosis") |
| pubmed:26445701 | a(CHEBI:teriflunomide) decreases p(HGNC:DHODH) |
| pubmed:26445701 | a(CHEBI:teriflunomide) decreases act(a(MESH:T-Lymphocytes)) |
| pubmed:26445701 | a(CHEBI:teriflunomide) decreases act(a(MESH:B-Lymphocytes)) |
| pubmed:26445701 | a(CHEBI:teriflunomide) decreases path(MESH:Inflammation) |
| pubmed:26445701 | a(CHEBI:teriflunomide) increases path(MESH:Alopecia) |
| pubmed:26445701 | a(CHEBI:teriflunomide) increases path(HP:Headache) |
| pubmed:26445701 | a(CHEBI:teriflunomide) increases path(DOID:diarrhea) |
| pubmed:26445701 | a(CHEBI:teriflunomide) increases p(MESH:Enzymes) |
| pubmed:26445701 | a(CHEBI:teriflunomide) decreases a(MESH:Lymphocytes) |
| pubmed:26445701 | a(CHEBI:teriflunomide) decreases a(MESH:Neutrophils) |
| pubmed:26445701 | a(CHEBI:teriflunomide) increases bp(GO:"positive regulation of blood pressure") |
| pubmed:26445701 | a(CHEBI:teriflunomide) increases path(DOID:tuberculosis) |
| pubmed:26445701 | complex(a(CHEBI:fingolimod), p(HGNC:S1PR1), loc(MESH:T-Lymphocytes)) decreases tloc(a(MESH:T-Lymphocytes), fromLoc(MESH:"Lymph Nodes"), toLoc(MESH:"Central Nervous System")) |
| pubmed:26445701 | a(CHEBI:leflunomide) decreases path(HP:"Rheumatoid arthritis") |
| pubmed:26445701 | a(CHEBI:leflunomide) increases a(CHEBI:teriflunomide) |
| pubmed:26445701 | p(HGNC:DHODH) decreases a(MESH:Pyrimidines) |
| pubmed:26445701 | composite(a(CHEBI:"dimethyl fumarate"), a(CHEBI:food)) decreases path(HP:"Abdominal pain") |
| pubmed:26445701 | a(MESH:Aspirin) decreases path(HP:Flushing) |
| pubmed:4255369 | path(MESH:"Motor Disorders") increases bp(GO:"cell death") |
| pubmed:29687724 | path(MESH:"Motor Disorders") association path(MESH:"Huntington Disease") |
| pubmed:27889190 | bp(MESH:"Axonal Transport") association path(DOID:"multiple sclerosis") |
| pubmed:27889190 | path(DOID:"progressive relapsing multiple sclerosis") association a(MESH:"Gray Matter") |
| pubmed:27889190 | path(DOID:"progressive relapsing multiple sclerosis") increases bp(GO:"microglial cell activation") |
| pubmed:27889190 | path(DOID:"progressive relapsing multiple sclerosis") increases path(HP:"CNS demyelination") |
| pubmed:27889190 | path(DOID:"progressive relapsing multiple sclerosis") association a(MESH:Neurites) |
| pubmed:27889190 | path(DOID:"progressive relapsing multiple sclerosis") increases bp(MESH:"Cell Death") |
| pubmed:27889190 | path(DOID:"progressive relapsing multiple sclerosis") decreases a(MESH:"Presynaptic Terminals") |
| pubmed:27889190 | path(DOID:"progressive relapsing multiple sclerosis") increases path(NCIT:C117277) |
| pubmed:27889190 | path(DOID:"progressive relapsing multiple sclerosis") increases path(MESH:Atrophy) |
| pubmed:27889190 | path(DOID:"progressive relapsing multiple sclerosis") negativeCorrelation bp(MESH:"Energy Metabolism") |
| pubmed:27889190 | a(MESH:"Gray Matter") association path(DOID:"progressive relapsing multiple sclerosis") |
| pubmed:30012004 | a(MESH:"Gray Matter") negativeCorrelation path(MESH:"Huntington Disease") |
| pubmed:30988501 | deg(a(MESH:"Gray Matter")) decreases bp(GO:cognition) |
| pubmed:30988501 | deg(a(MESH:"Gray Matter")) increases deg(a(MESH:"Cerebral Cortex")) |
| pubmed:27889190 | a(MESH:Neurites) association path(DOID:"progressive relapsing multiple sclerosis") |
| pubmed:22908190 | act(a(MESH:Neurites)) negativeCorrelation p(HGNC:APP, var("?")) |
| pubmed:28877763 | a(MESH:Neurites) positiveCorrelation act(p(MGI:Syk)) |
| pubmed:21722302 | bp(MESH:"Cell Death") increases tloc(p(HGNC:SNCA), fromLoc(GO:intracellular), toLoc(GO:"extracellular space")) |
| pubmed:21482353 | a(MESH:"Presynaptic Terminals") increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pubmed:27671637 | a(MESH:"Presynaptic Terminals") causesNoChange p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pubmed:27889190 | path(NCIT:C117277) association bp(MESH:"Neural Conduction") |
| pubmed:27889190 | path(NCIT:C117277) increases bp(MESH:"Energy Metabolism") |
| pubmed:27889190 | path(NCIT:C117277) increases a(MESH:Sodium, loc(GO:"axon cytoplasm")) |
| pubmed:27889190 | bp(MESH:"Neural Conduction") association path(NCIT:C117277) |
| pubmed:27889190 | bp(MESH:"Energy Metabolism") negativeCorrelation path(DOID:"progressive relapsing multiple sclerosis") |
| pubmed:30515821 | bp(MESH:"Energy Metabolism") negativeCorrelation act(p(HGNC:DNM1L)) |
| pubmed:30515821 | bp(MESH:"Energy Metabolism") negativeCorrelation path(DOID:"motor neuron disease") |
| pubmed:21718217 | bp(MESH:"Energy Metabolism") association p(FPLX:PPAR) |
| pubmed:21718217 | bp(MESH:"Energy Metabolism") positiveCorrelation p(FPLX:PPAR) |
| pubmed:21718217 | bp(MESH:"Energy Metabolism") association p(HGNC:PPARG) |
| pubmed:21718217 | bp(MESH:"Energy Metabolism") association p(HGNC:PPARGC1A) |
| pubmed:30012004 | bp(MESH:"Energy Metabolism") negativeCorrelation path(MESH:"Huntington Disease") |
| pubmed:20556492 | bp(MESH:"Energy Metabolism") negativeCorrelation path(DOID:"Huntington's disease") |
| pubmed:26968346 | bp(MESH:"Energy Metabolism") decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:lysosome), toLoc(GO:cytoplasm)) |
| pubmed:25784053 | bp(MESH:"Energy Metabolism") association p(HGNC:HSPD1) |
| pubmed:27889190 | a(MESH:Sodium, loc(GO:"axon cytoplasm")) increases act(p(MESH:"Sodium-Calcium Exchanger")) |
| pubmed:27889190 | composite(a(MESH:Sodium), p(MESH:"Sodium-Calcium Exchanger")) increases a(CHEBI:"calcium cation", loc(GO:"axon cytoplasm")) |
| pubmed:27889190 | a(CHEBI:"calcium cation", loc(GO:"axon cytoplasm")) increases act(p(HGNCGENEFAMILY:Calpains)) |
| pubmed:27889190 | a(CHEBI:"calcium cation", loc(GO:"axon cytoplasm")) decreases a(GO:cytoskeleton) |
| pubmed:28901280 | a(CHEBI:"calcium cation") increases bp(MESH:"Cell Proliferation") |
| pubmed:28901280 | a(CHEBI:"calcium cation") increases bp(MESH:"Cell Movement") |
| pubmed:28901280 | a(CHEBI:"calcium cation") increases bp(GO:angiogenesis) |
| pubmed:28901280 | a(CHEBI:"calcium cation") decreases bp(MESH:Apoptosis) |
| pubmed:21722302 | a(CHEBI:"calcium cation", loc(GO:cytoplasm)) increases act(p(HGNC:CAMK2B)) |
| pubmed:30061532 | act(a(GO:cytoskeleton)) association p(HGNC:DTNBP1) |
| pubmed:27889190 | bp(GO:"mitochondrial transport") negativeCorrelation path(CONSO:"mitochondrial dysfunction") |
| pubmed:27889190 | path(CONSO:"mitochondrial dysfunction") negativeCorrelation bp(GO:"mitochondrial transport") |
| pubmed:27889190 | path(CONSO:"mitochondrial dysfunction") increases path(MESH:"Oxidative Stress") |
| pubmed:27889190 | path(CONSO:"mitochondrial dysfunction") increases path(MESH:"DNA Damage") |
| pubmed:30967783 | path(CONSO:"mitochondrial dysfunction") association path(DOID:"multiple sclerosis") |
| pubmed:17017864 | path(CONSO:"mitochondrial dysfunction") increases bp(GO:"cell death") |
| pubmed:17017864 | path(CONSO:"mitochondrial dysfunction") increases bp(GO:"apoptotic process") |
| pubmed:23516100 | path(CONSO:"mitochondrial dysfunction") positiveCorrelation p(HGNC:APP, frag("1_?")) |
| pubmed:23516100 | path(CONSO:"mitochondrial dysfunction") increases act(p(HGNCGENEFAMILY:Caspases)) |
| pubmed:30362565 | path(CONSO:"mitochondrial dysfunction") increases a(CHEBI:"reactive oxygen species") |
| pubmed:29758300 | path(CONSO:"mitochondrial dysfunction") increases a(CHEBI:"reactive oxygen species") |
| pubmed:30012004 | path(CONSO:"mitochondrial dysfunction") positiveCorrelation path(MESH:"Huntington Disease") |
| pubmed:21722302 | path(CONSO:"mitochondrial dysfunction") increases bp(GO:"motor neuron apoptotic process") |
| pubmed:27299292 | path(CONSO:"mitochondrial dysfunction") positiveCorrelation path(DOID:"spinal muscular atrophy") |
| pubmed:29758300 | path(CONSO:"mitochondrial dysfunction") increases path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | path(CONSO:"mitochondrial dysfunction") increases path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | path(CONSO:"mitochondrial dysfunction") decreases a(CHEBI:ATP) |
| pubmed:29758300 | path(CONSO:"mitochondrial dysfunction") increases a(CHEBI:amyloid-beta) |
| pubmed:29758300 | path(CONSO:"mitochondrial dysfunction") increases p(HGNC:MAPT) |
| pubmed:29758300 | path(CONSO:"mitochondrial dysfunction") increases bp(GO:mitophagy) |
| pubmed:28173111 | path(CONSO:"mitochondrial dysfunction") positiveCorrelation r(MGI:Dnm1l) |
| pubmed:27181519 | path(CONSO:"mitochondrial dysfunction") increases complex(GO:"cytoplasmic stress granule") |
| pubmed:30988501 | path(CONSO:"mitochondrial dysfunction") increases deg(a(MESH:Neurons)) |
| pubmed:27889190 | path(MESH:"DNA Damage") decreases bp(MESH:"Energy Metabolism") |
| pubmed:27889190 | path(MESH:"DNA Damage") increases a(MESH:"Reactive Oxygen Species") |
| pubmed:30967783 | a(MESH:"Reactive Oxygen Species") increases path(MESH:"Mitochondrial Degradation") |
| pubmed:26979166 | a(MESH:"Reactive Oxygen Species") increases deg(a(MESH:"White Matter")) |
| pubmed:26979166 | a(MESH:"Reactive Oxygen Species") increases deg(a(MESH:"Gray Matter")) |
| pubmed:27889190 | a(CHEBI:biotin) increases bp(MESH:"Energy Metabolism") |
| pubmed:27889190 | a(CHEBI:biotin) increases act(a(MESH:Axons)) |
| pubmed:27889190 | a(CHEBI:biotin) decreases path(CONSO:Neurodegeneration) |
| pubmed:27889190 | a(CHEBI:biotin) increases bp(MESH:Remyelination) |
| pubmed:30061532 | path(CONSO:Neurodegeneration) association act(a(GO:synapse)) |
| pubmed:19126755 | path(CONSO:Neurodegeneration) increases bp(GO:cognition) |
| pubmed:19126755 | path(CONSO:Neurodegeneration) negativeCorrelation p(MGI:Chrnb2) |
| pubmed:26813123 | path(CONSO:Neurodegeneration) negativeCorrelation bp(GO:memory) |
| pubmed:26813123 | path(CONSO:Neurodegeneration) association bp(GO:"synaptic transmission, glutamatergic") |
| pubmed:26813123 | path(CONSO:Neurodegeneration) association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:31248781 | path(CONSO:Neurodegeneration) association p(MESH:"Neurofibrillary Tangles") |
| pubmed:18986241 | path(CONSO:Neurodegeneration) association path(MESH:"Cognitive Dysfunction") |
| pubmed:30106381 | path(CONSO:Neurodegeneration) association p(HGNC:WFS1) |
| pubmed:21722302 | path(CONSO:Neurodegeneration) association path(MESH:"Alzheimer Disease") |
| pubmed:21722302 | path(CONSO:Neurodegeneration) association path(MESH:"Parkinson Disease") |
| pubmed:21722302 | path(CONSO:Neurodegeneration) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:21722302 | path(CONSO:Neurodegeneration) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:21722302 | path(CONSO:Neurodegeneration) association path(MESH:"Prion Diseases") |
| pubmed:21722302 | path(CONSO:Neurodegeneration) association a(CONSO:"amyloid-beta aggregates") |
| pubmed:29758300 | path(CONSO:Neurodegeneration) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:18930136 | path(CONSO:Neurodegeneration) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:18930136 | path(CONSO:Neurodegeneration) negativeCorrelation bp(GO:"cellular protein catabolic process") |
| pubmed:17403556 | path(CONSO:Neurodegeneration) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26631930 | path(CONSO:Neurodegeneration) association tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) |
| pubmed:26631930 | path(CONSO:Neurodegeneration) association act(p(HGNC:MAPT)) |
| pubmed:17187063 | path(CONSO:Neurodegeneration) positiveCorrelation complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pubmed:19251756 | path(CONSO:Neurodegeneration) negativeCorrelation act(p(INTERPRO:"Triosephosphate isomerase")) |
| pubmed:22952452 | path(CONSO:Neurodegeneration) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:27181519 | path(CONSO:Neurodegeneration) association p(HGNC:TBK1) |
| pubmed:27889190 | a(DRUGBANK:Clemastine) increases bp(MESH:"Vision, Ocular") |
| pubmed:27889190 | a(DRUGBANK:Clemastine) increases bp(HP:"Optic neuropathy") |
| pubmed:30967783 | bp(GO:"neuroinflammatory response") increases path(DOID:"multiple sclerosis") |
| pubmed:30967783 | bp(GO:"neuroinflammatory response") increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30967783 | bp(GO:"neuroinflammatory response") increases tloc(p(HGNC:C1QA), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30967783 | bp(GO:"neuroinflammatory response") decreases act(a(MESH:Astrocytes)) |
| pubmed:30967783 | bp(GO:"neuroinflammatory response") negativeCorrelation act(a(MESH:Neurons)) |
| pubmed:30967783 | bp(GO:"neuroinflammatory response") negativeCorrelation act(a(MESH:Oligodendroglia)) |
| pubmed:30988501 | bp(GO:"neuroinflammatory response") increases path(MESH:"Mental Disorders") |
| pubmed:30967783 | complex(p(HGNC:CX3CL1), p(HGNC:CX3CR1)) increases bp(MESH:"Neuronal Plasticity") |
| pubmed:30967783 | complex(p(HGNC:CX3CL1), p(HGNC:CX3CR1)) increases bp(GO:"generation of neurons") |
| pubmed:30967783 | p(HGNC:CX3CR1) increases bp(MESH:"Cell Survival") |
| pubmed:21482353 | bp(GO:"generation of neurons") association act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:30935091 | bp(MESH:"Cell Survival") increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:22236693 | bp(MESH:"Cell Survival") positiveCorrelation p(HGNC:NGFR) |
| pubmed:31248781 | bp(MESH:"Cell Survival") positiveCorrelation bp(MESH:Neuroprotection) |
| pubmed:31248781 | bp(MESH:"Cell Survival") association bp(GO:"neurotrophin signaling pathway") |
| pubmed:31248781 | bp(MESH:"Cell Survival") association p(HGNC:CREBBP) |
| pubmed:28901280 | bp(MESH:"Cell Survival") association a(MESH:Acetylcholine) |
| pubmed:30126037 | bp(MESH:"Cell Survival") association bp(GO:"cellular senescence") |
| pubmed:29540553 | bp(GO:"learning or memory") positiveCorrelation p(HGNC:SIRT1) |
| pubmed:27190210 | bp(GO:"learning or memory") association p(HGNC:CHRNA7) |
| pubmed:29428175 | bp(GO:"learning or memory") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:30697142 | bp(GO:"learning or memory") positiveCorrelation a(CHEBI:"(-)-cotinine") |
| pubmed:30697142 | bp(GO:"learning or memory") association bp(MESH:"Neuronal Plasticity") |
| pubmed:30697142 | bp(GO:"learning or memory") negativeCorrelation act(p(HGNC:GSK3B)) |
| pubmed:30740335 | bp(GO:"learning or memory") association p(HGNC:XBP1) |
| pubmed:30967783 | p(HGNC:NTRK2) regulates bp(MESH:"Neuronal Plasticity") |
| pubmed:27013968 | act(p(HGNC:NTRK2), ma(GO:"neurotrophin TRKB receptor binding")) negativeCorrelation p(HGNC:HTT, pmod(HBP:"CAG repeats")) |
| pubmed:27013968 | act(p(HGNC:NTRK2)) increases bp(GO:"ERK1 and ERK2 cascade") |
| pubmed:27181519 | act(p(HGNC:NTRK2)) positiveCorrelation g(HGNC:C9orf72) |
| pubmed:30967783 | bp(GO:"cellular response to stress") increases bp(GO:"microglial cell activation") |
| pubmed:30967783 | bp(GO:"cellular response to stress") increases composite(a(MESH:Microglia), a(MESH:Neurons)) |
| pubmed:30740335 | bp(GO:"cellular response to stress") decreases bp(GO:"protein transport") |
| pubmed:30740335 | bp(GO:"cellular response to stress") increases p(HGNC:ATF6, loc(GO:nucleus)) |
| pubmed:30740335 | bp(GO:"cellular response to stress") association p(HGNC:SIGMAR1) |
| pubmed:27209302 | bp(GO:"cellular response to stress") increases act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:27299292 | bp(GO:"cellular response to stress") increases p(HGNC:TFEB) |
| pubmed:27299292 | bp(GO:"cellular response to stress") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) |
| pubmed:27299292 | bp(GO:"cellular response to stress") increases act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:29758300 | bp(GO:"cellular response to stress") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) |
| pubmed:29758300 | bp(GO:"cellular response to stress") increases complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) |
| pubmed:18930136 | bp(GO:"cellular response to stress") increases p(HGNC:SQSTM1) |
| pubmed:18930136 | bp(GO:"cellular response to stress") increases r(HGNC:SQSTM1) |
| pubmed:21882945 | bp(GO:"cellular response to stress") increases a(MESH:"Heat-Shock Proteins") |
| pubmed:21882945 | bp(GO:"cellular response to stress") increases a(CONSO:"Hsp27 oligomers") |
| pubmed:30967783 | path(MESH:Light) decreases bp(GO:"microglial cell activation") |
| pubmed:30967783 | path(MESH:Light) decreases composite(a(MESH:Microglia), a(MESH:Neurons)) |
| pubmed:22372633 | p(MESH:Proteins, pmod(CONSO:misfolded)) increases p(CONSO:"protein aggregates") |
| pubmed:27181519 | p(MESH:Proteins, pmod(CONSO:misfolded)) increases p(CONSO:"protein aggregates") |
| pubmed:21722302 | p(MESH:Proteins, pmod(CONSO:misfolded)) association bp(MESH:"Endoplasmic Reticulum Stress") |
| pubmed:21722302 | p(MESH:Proteins, pmod(CONSO:misfolded)) increases act(p(HGNC:ERN1)) |
| pubmed:21722302 | p(MESH:Proteins, pmod(CONSO:misfolded)) increases act(p(HGNC:EIF2AK3)) |
| pubmed:21722302 | p(MESH:Proteins, pmod(CONSO:misfolded)) increases act(p(HGNC:ATF6)) |
| pubmed:21722302 | p(MESH:Proteins, pmod(CONSO:misfolded)) increases bp(CONSO:"protein aggregation") |
| pubmed:21722302 | p(MESH:Proteins, pmod(CONSO:misfolded)) increases bp(CONSO:"protein aggregation") |
| pubmed:21722302 | p(MESH:Proteins, pmod(CONSO:misfolded)) increases bp(MESH:"Unfolded Protein Response") |
| pubmed:29758300 | p(MESH:Proteins, pmod(CONSO:misfolded)) decreases bp(GO:"neuron cellular homeostasis") |
| pubmed:29758300 | p(MESH:Proteins, pmod(CONSO:misfolded)) decreases a(MESH:Neurons) |
| pubmed:29311797 | deg(p(MESH:Proteins, pmod(CONSO:misfolded))) association a(MESH:"Molecular Chaperones") |
| pubmed:27181519 | p(MESH:Proteins, pmod(CONSO:misfolded)) association path(DOID:"prion disease") |
| pubmed:30967783 | a(NCIT:C118474) increases bp(GO:"microglial cell activation") |
| pubmed:30967783 | a(NCIT:C118474) increases bp(GO:"microglial cell activation") |
| pubmed:30967783 | a(NCIT:C118474) increases bp(GO:"macrophage activation") |
| pubmed:19126755 | bp(GO:"establishment of blood-brain barrier") association a(MESH:Manduca) |
| pubmed:30967783 | p(HGNC:CSF1R) increases a(MESH:Pericytes) |
| pubmed:30967783 | a(MESH:"Leukocytes, Mononuclear", loc(NCIT:C74601)) isA a(MESH:"Antigen-Presenting Cells") |
| pubmed:30967783 | a(MESH:"Leukocytes, Mononuclear", loc(NCIT:C74601)) increases bp(GO:"T cell activation") |
| pubmed:30967783 | a(MESH:"Leukocytes, Mononuclear") association path(DOID:"multiple sclerosis") |
| pubmed:30967783 | a(MESH:"Antigen-Presenting Cells") increases bp(MESH:"Adaptive Immunity") |
| pubmed:30988501 | a(MESH:"Antigen-Presenting Cells") increases bp(MESH:"Immunologic Surveillance") |
| pubmed:30967783 | a(NCIT:C156004) increases p(HGNC:IL6) |
| pubmed:30967783 | a(NCIT:C156004) increases p(HGNC:IFNG) |
| pubmed:30967783 | a(NCIT:C156004) increases p(MESH:Interleukin-23) |
| pubmed:30967783 | a(NCIT:C156004) increases p(HGNC:TNF) |
| pubmed:30967783 | a(NCIT:C156004) increases p(HGNC:NOS2) |
| pubmed:30967783 | a(NCIT:C156004) increases p(HGNC:CCL4) |
| pubmed:30967783 | a(NCIT:C156004) increases p(HGNC:CCL5) |
| pubmed:30967783 | a(NCIT:C156004) increases p(HGNC:CCL8) |
| pubmed:30967783 | a(NCIT:C156004) increases p(HGNC:CXCL2) |
| pubmed:30967783 | a(NCIT:C156004) increases p(HGNC:PF4) |
| pubmed:30967783 | a(NCIT:C156004) increases p(HGNC:CXCL9) |
| pubmed:30967783 | a(NCIT:C156004) isA a(MESH:"Antigen-Presenting Cells") |
| pubmed:30967783 | a(NCIT:C156004) increases bp(MESH:"Adaptive Immunity") |
| pubmed:30967783 | a(NCIT:C156004) decreases p(MESH:Proteins, pmod(CONSO:misfolded)) |
| pubmed:30967783 | a(NCIT:C123783) increases p(HGNC:IL4) |
| pubmed:30967783 | a(NCIT:C123783) increases p(HGNC:IL10) |
| pubmed:30967783 | a(NCIT:C123783) increases p(HGNC:IL13) |
| pubmed:30967783 | a(NCIT:C123783) increases p(HGNC:TGFB1) |
| pubmed:30967783 | a(NCIT:C123783) regulates bp(MESH:Immunity) |
| pubmed:30967783 | a(NCIT:C123783) decreases path(MESH:Inflammation) |
| pubmed:30967783 | a(NCIT:C123783) increases bp(GO:"tissue remodeling") |
| pubmed:30967783 | a(NCIT:C123783) increases bp(GO:angiogenesis) |
| pubmed:30967783 | a(NCIT:C123783) increases deg(a(MESH:Parasites)) |
| pubmed:30967783 | a(NCIT:C123783) association a(MESH:"Th2 Cells") |
| pubmed:30967783 | a(NCIT:C123783) increases bp(GO:"regulatory T cell differentiation") |
| pubmed:30967783 | a(NCIT:C123783, loc(MESH:"Spinal Cord")) increases bp(MESH:Remyelination) |
| pubmed:30967783 | p(MESH:Interleukin-23) increases path(MESH:Inflammation) |
| pubmed:30967783 | p(HGNC:CCL5) increases bp(GO:"inflammatory response") |
| pubmed:30967783 | p(HGNC:CCL5) increases path(EFO:"experimental autoimmune encephalomyelitis") |
| pubmed:30967783 | p(HGNC:CCL5) increases path(DOID:"multiple sclerosis") |
| pubmed:30967783 | p(HGNC:CXCL2) increases bp(MESH:"Neutrophil Infiltration") |
| pubmed:30967783 | p(HGNC:CXCL2) increases path(EFO:"experimental autoimmune encephalomyelitis") |
| pubmed:30967783 | bp(GO:"detection of wounding") increases act(a(MESH:Microglia, loc(NCIT:C74601))) |
| pubmed:30967783 | bp(GO:"detection of wounding") increases act(a(MESH:Macrophages, loc(MESH:"Choroid Plexus"))) |
| pubmed:30967783 | bp(GO:"detection of wounding") increases act(a(MESH:Macrophages, loc(NCIT:C83196))) |
| pubmed:30967783 | bp(GO:"detection of wounding") increases act(a(MESH:Macrophages, loc(MESH:Meninges))) |
| pubmed:30967783 | a(CHEBI:"2 L-glutamate") increases bp(GO:"excitatory postsynaptic potential") |
| pubmed:30967783 | a(CHEBI:"2 L-glutamate", loc(MESH:Synapses)) directlyDecreases bp(MESH:"Synaptic Potentials") |
| pubmed:30967783 | a(CHEBI:"adenosine triphosphate", loc(MESH:Astrocytes)) increases bp(GO:"microglial cell activation") |
| pubmed:30967783 | p(HGNC:C1QA) negativeCorrelation act(a(MESH:Astrocytes)) |
| pubmed:30967783 | a(MESH:"Reactive Nitrogen Species") increases path(MESH:"Mitochondrial Degradation") |
| pubmed:30967783 | complex(a(MESH:Antigens), a(MESH:Microglia)) increases p(HGNCGENEFAMILY:"Histocompatibility complex") |
| pubmed:30967783 | complex(a(MESH:Antigens), a(MESH:Microglia)) increases bp(GO:"T cell activation") |
| pubmed:30967783 | p(MESH:"Histocompatibility Antigens Class II") causesNoChange path(DOID:"multiple sclerosis") |
| pubmed:30967783 | p(HGNC:CCL2) increases bp(GO:"inflammatory response") |
| pubmed:30967783 | p(HGNC:CCL2) increases path(EFO:"experimental autoimmune encephalomyelitis") |
| pubmed:30967783 | p(HGNC:CCL2) increases path(DOID:"multiple sclerosis") |
| pubmed:30967783 | p(HGNC:CCL2) increases a(MESH:"Leukocytes, Mononuclear", loc(MESH:"Central Nervous System")) |
| pubmed:26836182 | p(HGNC:CCL2) positiveCorrelation path(CONSO:neuroinflammation) |
| pubmed:26979166 | p(HGNC:CCL2) association path(MESH:Inflammation) |
| pubmed:21718217 | p(HGNC:CCL2) increases bp(GO:"microglial cell activation") |
| pubmed:30967783 | p(HGNC:TNFAIP3) regulates bp(GO:"microglial cell activation") |
| pubmed:30967783 | p(HGNC:TNFAIP3) regulates bp(MESH:"Synaptic Potentials") |
| pubmed:30967783 | p(HGNC:TNFAIP3) decreases path(DOID:"multiple sclerosis") |
| pubmed:30967783 | p(HGNC:TREM2) increases bp(GO:"microglial cell activation") |
| pubmed:30967783 | p(HGNC:TREM2) decreases path(HP:"CNS demyelination") |
| pubmed:30967783 | p(HGNC:TREM2) association path(MESH:Inflammation) |
| pubmed:23533697 | p(HGNC:TREM2) decreases path(MESH:Inflammation) |
| pubmed:23533697 | p(HGNC:TREM2) decreases bp(GO:"response to oxidative stress") |
| pubmed:23533697 | p(HGNC:TREM2) decreases bp(GO:"response to oxidative stress") |
| pubmed:23533697 | p(HGNC:TREM2) association bp(GO:"inflammatory response") |
| pubmed:23533697 | p(HGNC:TREM2) decreases bp(GO:"inflammatory response") |
| pubmed:23533697 | p(HGNC:TREM2) increases bp(GO:phagocytosis) |
| pubmed:29626319 | p(HGNC:TREM2) association bp(GO:phagocytosis) |
| pubmed:29626319 | p(HGNC:TREM2) increases bp(GO:phagocytosis) |
| pubmed:23533697 | p(HGNC:TREM2) decreases bp(GO:"cytokine production") |
| pubmed:23533697 | p(HGNC:TREM2) increases path(MESH:"Alzheimer Disease") |
| pubmed:31413141 | p(HGNC:TREM2) increases p(HGNC:TREM2, frag("?")) |
| pubmed:31413141 | p(HGNC:TREM2) causesNoChange p(HGNC:TREM2, frag("?")) |
| pubmed:29758300 | p(HGNC:TREM2) positiveCorrelation p(HGNC:MAPT) |
| pubmed:29758300 | p(HGNC:TREM2) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29758300 | p(HGNC:TREM2) increases bp(GO:macroautophagy) |
| pubmed:29758300 | p(HGNC:TREM2) increases bp(GO:"metabolic process") |
| pubmed:29758300 | p(HGNC:TREM2) increases bp(GO:"metabolic process") |
| pubmed:29758300 | p(HGNC:TREM2) increases act(complex(GO:"TOR complex")) |
| pubmed:29626319 | act(p(HGNC:TREM2)) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pubmed:30967783 | p(MESH:"Macrophage-1 Antigen") increases bp(GO:"microglial cell activation") |
| pubmed:30967783 | p(HGNC:SRPRA) increases bp(GO:"microglial cell activation") |
| pubmed:30967783 | g(HGNC:PRSS3P2) increases bp(GO:neurogenesis) |
| pubmed:30967783 | p(NCIT:C20426) increases bp(GO:neurogenesis) |
| pubmed:30967783 | p(MESH:Activins) increases bp(GO:"oligodendrocyte differentiation") |
| pubmed:30967783 | p(MESH:Activins) decreases bp(GO:"inflammatory response") |
| pubmed:30967783 | p(MESH:Activins) increases bp(MESH:Remyelination) |
| pubmed:30967783 | p(HGNC:TNFRSF1B) decreases path(EFO:"experimental autoimmune encephalomyelitis") |
| pubmed:30967783 | p(HGNC:TNFRSF1B) decreases a(MESH:"Leukocytes, Mononuclear", loc(MESH:"Central Nervous System")) |
| pubmed:30967783 | p(HGNC:TNFRSF1B) decreases path(HP:"CNS demyelination") |
| pubmed:30967783 | p(HGNC:TNFRSF1B) decreases bp(GO:"T cell activation") |
| pubmed:30967783 | p(HGNC:TRPM2) increases p(HGNC:CXCL2) |
| pubmed:23702978 | p(HGNC:TRPM2) increases act(p(HGNC:NLRP3)) |
| pubmed:23702978 | act(p(HGNC:TRPM2)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:30967783 | bp(GO:"T-helper 17 cell chemotaxis") positiveCorrelation p(HGNC:IL1B) |
| pubmed:30967783 | path(HP:Autoimmunity) positiveCorrelation p(HGNC:IL6) |
| pubmed:30988501 | path(HP:Autoimmunity) increases path(CONSO:neuroinflammation) |
| pubmed:30988501 | path(HP:Autoimmunity) increases path(MESH:Inflammation) |
| pubmed:30988501 | path(HP:Autoimmunity) increases path(DOID:"anxiety disorder") |
| pubmed:30988501 | path(HP:Autoimmunity) increases path(DOID:"sleep disorder") |
| pubmed:30988501 | path(HP:Autoimmunity) increases path(HP:Mania) |
| pubmed:30988501 | path(HP:Autoimmunity) increases path(HP:Paranoia) |
| pubmed:30988501 | path(HP:Autoimmunity) increases path(HP:"Memory impairment") |
| pubmed:30988501 | path(HP:Autoimmunity) increases path(MESH:"Language Disorders") |
| pubmed:30988501 | path(HP:Autoimmunity) increases path(HP:Agitation) |
| pubmed:30988501 | path(HP:Autoimmunity) increases path(MESH:Catatonia) |
| pubmed:30988501 | path(HP:Autoimmunity) increases path(HP:"Abnormality of movement") |
| pubmed:30967783 | p(HGNC:CCR4) decreases a(MESH:Macrophages) |
| pubmed:30967783 | p(HGNC:CCR4) increases path(EFO:"experimental autoimmune encephalomyelitis") |
| pubmed:30967783 | p(HGNC:NR4A1) decreases a(DRUGBANK:Norepinephrine) |
| pubmed:30967783 | p(HGNC:NR4A1) decreases a(MESH:"Leukocytes, Mononuclear", loc(MESH:"Central Nervous System")) |
| pubmed:30967783 | p(HGNC:NR4A1) decreases path(EFO:"experimental autoimmune encephalomyelitis") |
| pubmed:30967783 | a(CHEBI:"clondronate(2-)", loc(MESH:Liposomes)) decreases a(MESH:Macrophages) |
| pubmed:30967783 | a(CHEBI:"clondronate(2-)", loc(MESH:Liposomes)) decreases path(EFO:"experimental autoimmune encephalomyelitis") |
| pubmed:30967783 | p(HGNC:ICAM1) increases a(MESH:"Leukocytes, Mononuclear", loc(MESH:"Central Nervous System")) |
| pubmed:30640040 | p(HGNC:ICAM1) association a(PUBCHEM:9839311) |
| pubmed:30967783 | p(HGNC:CCL3) increases a(MESH:"Leukocytes, Mononuclear", loc(MESH:"Central Nervous System")) |
| pubmed:30967783 | p(MESH:"Nerve Growth Factors") decreases act(a(MESH:"Leukocytes, Mononuclear")) |
| pubmed:30967783 | p(MESH:"Nerve Growth Factors") decreases a(MESH:"Leukocytes, Mononuclear", loc(MESH:"Central Nervous System")) |
| pubmed:30967783 | p(MESH:"Anti-Inflammatory Agents") decreases act(a(MESH:"Leukocytes, Mononuclear")) |
| pubmed:30967783 | p(MESH:"Anti-Inflammatory Agents") decreases a(MESH:"Leukocytes, Mononuclear", loc(MESH:"Central Nervous System")) |
| pubmed:30967783 | a(MESH:"Choroid Plexus") increases a(NCIT:C123783, loc(MESH:"Spinal Cord")) |
| pubmed:29626319 | a(MESH:"Choroid Plexus") increases a(MESH:"Cerebrospinal Fluid") |
| pubmed:30967783 | a(DRUGBANK:"Ethyl pyruvate") association bp(GO:"macrophage activation") |
| pubmed:30967783 | a(DRUGBANK:"Ethyl pyruvate") decreases bp(GO:"macrophage activation") |
| pubmed:30967783 | a(DRUGBANK:"Ethyl pyruvate") association bp(GO:"microglial cell activation") |
| pubmed:30967783 | a(DRUGBANK:"Ethyl pyruvate") decreases bp(GO:"microglial cell activation") |
| pubmed:30967783 | a(DRUGBANK:"Ethyl pyruvate") decreases path(EFO:"experimental autoimmune encephalomyelitis") |
| pubmed:30967783 | a(CHEBI:spermidine) association bp(GO:"macrophage activation") |
| pubmed:30967783 | a(CHEBI:spermidine) association bp(GO:"microglial cell activation") |
| pubmed:30116051 | a(CHEBI:spermidine) decreases p(HGNC:ATG7, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30116051 | a(CHEBI:spermidine) decreases p(FPLX:"Histone_H3", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30116051 | a(CHEBI:spermidine) increases act(p(HGNC:BECN1)) |
| pubmed:30116051 | a(CHEBI:spermidine) decreases act(p(HGNC:CASP3)) |
| pubmed:30967783 | a(CHEBI:"bryostatin 1") association bp(GO:"macrophage activation") |
| pubmed:30967783 | a(CHEBI:"bryostatin 1") association bp(GO:"microglial cell activation") |
| pubmed:30967783 | a(CHEBI:forskolin) association bp(GO:"macrophage activation") |
| pubmed:30967783 | a(CHEBI:forskolin) association bp(GO:"microglial cell activation") |
| pubmed:30967783 | a(CHEBI:forskolin) decreases p(HGNC:CD86) |
| pubmed:30967783 | a(CHEBI:forskolin) decreases path(EFO:"experimental autoimmune encephalomyelitis") |
| pubmed:30967783 | a(CHEBI:forskolin) increases p(HGNC:ARG1, loc(MESH:Macrophages)) |
| pubmed:30967783 | a(DRUGBANK:Lenalidomide) association bp(GO:"macrophage activation") |
| pubmed:30967783 | a(DRUGBANK:Lenalidomide) association bp(GO:"microglial cell activation") |
| pubmed:30967783 | p(HGNC:CD86) increases path(EFO:"experimental autoimmune encephalomyelitis") |
| pubmed:30967783 | r(HGNC:GAS5) decreases a(MESH:Microglia) |
| pubmed:30967783 | a(MESH:Glucocorticoids) decreases path(DOID:"relapsing-remitting multiple sclerosis") |
| pubmed:30967783 | a(MESH:Glucocorticoids) isA a(CHEBI:"immunosuppressive agent") |
| pubmed:21718217 | a(MESH:Glucocorticoids) decreases a(MESH:Macrophages) |
| pubmed:30988501 | a(CHEBI:"immunosuppressive agent") decreases path(DOID:encephalitis) |
| pubmed:28760828 | p(HGNC:HDAC6) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:28760828 | p(HGNC:HDAC6) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:25031639 | p(HGNC:HDAC6) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:25031639 | p(HGNC:HDAC6) regulates p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:22372633 | p(HGNC:HDAC6) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30935091 | p(HGNC:HDAC6) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:29661268 | act(p(HGNC:HDAC6)) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation"), loc(CONSO:"KXGS motif")) |
| pubmed:28760828 | p(HGNC:HDAC6) causesNoChange p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 290)) |
| pubmed:28760828 | act(p(HGNC:HDAC6)) association p(CONSO:"Tau aggregates") |
| pubmed:22372633 | act(p(HGNC:HDAC6), ma(GO:"deacetylase activity")) causesNoChange p(CONSO:"Tau aggregates") |
| pubmed:30935091 | p(HGNC:HDAC6) increases p(CONSO:"Tau aggregates") |
| pubmed:29661268 | act(p(HGNC:HDAC6)) increases p(CONSO:"Tau aggregates") |
| pubmed:28760828 | p(HGNC:HDAC6) increases p(HGNC:MAPT) |
| pubmed:30935091 | act(p(HGNC:HDAC6)) increases act(p(HGNC:MAPT), ma(MESH:"Protein Transport")) |
| pubmed:30935091 | p(HGNC:HDAC6) increases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) |
| pubmed:30935091 | p(HGNC:HDAC6) increases p(HGNC:MAPT) |
| pubmed:29661268 | act(p(HGNC:HDAC6)) decreases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) |
| pubmed:28760828 | p(HGNC:HDAC6) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) |
| pubmed:28760828 | act(p(HGNC:HDAC6)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) |
| pubmed:25031639 | p(HGNC:HDAC6) decreases act(p(HGNC:EP300)) |
| pubmed:25031639 | p(HGNC:HDAC6) increases p(HGNC:MAPT, pmod(CONSO:"protein aggregates")) |
| pubmed:25031639 | act(p(HGNC:HDAC6)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:25031639 | act(p(HGNC:HDAC6)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:25031639 | act(p(HGNC:HDAC6)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) |
| pubmed:25031639 | act(p(HGNC:HDAC6)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) |
| pubmed:25031639 | p(HGNC:HDAC6) positiveCorrelation path(DOID:tauopathy) |
| pubmed:25031639 | p(HGNC:HDAC6) increases act(p(HGNC:MARK2)) |
| pubmed:25031639 | p(HGNC:HDAC6) decreases p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:25031639 | act(p(HGNC:HDAC6)) decreases p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:25031639 | p(HGNC:HDAC6) decreases p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:25031639 | p(HGNC:HDAC6) regulates p(HGNC:MAPT, pmod(MESH:Polymerization)) |
| pubmed:25031639 | act(p(HGNC:HDAC6)) increases p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25031639 | act(p(HGNC:HDAC6)) negativeCorrelation act(complex(GO:microtubule), ma(GO:"microtubule motor activity")) |
| pubmed:25031639 | act(p(HGNC:HDAC6)) negativeCorrelation a(MESH:Microtubules) |
| pubmed:22372633 | p(HGNC:HDAC6) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:22372633 | act(p(HGNC:HDAC6), ma(GO:"deacetylase activity")) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:22372633 | p(HGNC:HDAC6) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:22372633 | p(HGNC:HDAC6) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:22372633 | p(HGNC:HDAC6) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:22372633 | p(HGNC:HDAC6) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30935091 | p(HGNC:HDAC6) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30935091 | p(HGNC:HDAC6) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30935091 | p(HGNC:HDAC6) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30935091 | p(HGNC:HDAC6) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation"), loc(MESH:Brain)) |
| pubmed:30935091 | p(HGNC:HDAC6) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:29661268 | p(HGNC:HDAC6) increases complex(p(HGNC:HDAC6), p(HGNC:MAPT)) |
| pubmed:22372633 | p(HGNC:HDAC6) negativeCorrelation bp(GO:"axonal transport of mitochondrion") |
| pubmed:30935091 | p(HGNC:HDAC6) negativeCorrelation bp(GO:"axonal transport of mitochondrion") |
| pubmed:22372633 | p(HGNC:HDAC6) decreases composite(a(MESH:Microtubules), p(MESH:Dyneins), p(MESH:Kinesin)) |
| pubmed:22372633 | p(HGNC:HDAC6) positiveCorrelation bp(GO:"microtubule depolymerization") |
| pubmed:22372633 | p(HGNC:HDAC6) decreases complex(p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")), p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation"))) |
| pubmed:22372633 | p(HGNC:HDAC6) increases p(MESH:Microtubules, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:22372633 | p(HGNC:HDAC6) decreases p(HGNC:MAPRE1) |
| pubmed:22372633 | p(HGNC:HDAC6) decreases p(HGNC:ACTR1A) |
| pubmed:22372633 | act(p(HGNC:HDAC6), ma(GO:"deacetylase activity")) decreases p(HGNC:PRX, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:22372633 | p(HGNC:HDAC6) decreases p(HGNC:HSF1) |
| pubmed:22372633 | p(HGNC:HDAC6) increases act(p(HGNC:HSF1)) |
| pubmed:22372633 | p(HGNC:HDAC6) decreases complex(p(HGNC:HDAC6), p(HGNC:HSF1), p(HGNCGENEFAMILY:"Heat shock 90kDa proteins")) |
| pubmed:22372633 | p(HGNC:HDAC6) decreases act(p(HGNCGENEFAMILY:"Heat shock 90kDa proteins"), ma(GO:"vascular endothelial growth factor receptor 1 binding")) |
| pubmed:29844403 | p(HGNC:HDAC6) association p(HGNCGENEFAMILY:"Heat shock 90kDa proteins") |
| pubmed:22372633 | p(HGNC:HDAC6) decreases p(HGNC:FLT1) |
| pubmed:22372633 | p(HGNC:HDAC6) decreases p(HGNC:KDR) |
| pubmed:22372633 | p(HGNC:HDAC6) decreases p(HGNCGENEFAMILY:"Heat shock 90kDa proteins", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:29844403 | p(HGNC:HDAC6) decreases p(HGNCGENEFAMILY:"Heat shock 90kDa proteins", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30935091 | p(HGNC:HDAC6) decreases p(HGNCGENEFAMILY:"Heat shock 90kDa proteins", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:22372633 | p(HGNC:HDAC6) causesNoChange bp(MESH:"Cell Survival") |
| pubmed:22372633 | p(HGNC:HDAC6) decreases bp(MESH:"Cell Survival") |
| pubmed:30935091 | p(HGNC:HDAC6) decreases bp(MESH:"Cell Survival") |
| pubmed:22372633 | p(HGNC:HDAC6) causesNoChange bp(MESH:Growth) |
| pubmed:22372633 | p(HGNC:HDAC6) decreases p(CONSO:"protein aggregates", pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:22372633 | p(HGNC:HDAC6) decreases bp(GO:"programmed cell death") |
| pubmed:22372633 | p(HGNC:HDAC6) decreases path(DOID:"neurodegenerative disease") |
| pubmed:22372633 | p(HGNC:HDAC6) decreases path(DOID:"neurodegenerative disease") |
| pubmed:22372633 | p(HGNC:HDAC6) negativeCorrelation path(DOID:"neurodegenerative disease") |
| pubmed:22372633 | p(HGNC:HDAC6) increases bp(GO:"protein ubiquitination") |
| pubmed:22372633 | p(HGNC:HDAC6) increases p(HGNC:MAP1LC3A, loc(GO:aggresome)) |
| pubmed:22372633 | p(HGNC:HDAC6) increases act(p(HGNC:CTTN), ma(GO:"actin filament binding")) |
| pubmed:22372633 | p(HGNC:HDAC6) increases bp(GO:"autophagosome-lysosome fusion") |
| pubmed:27181519 | p(HGNC:HDAC6) increases bp(GO:"autophagosome-lysosome fusion") |
| pubmed:22372633 | p(HGNC:HDAC6) positiveCorrelation bp(GO:"autophagosome maturation") |
| pubmed:22372633 | p(HGNC:HDAC6) decreases p(CONSO:"protein aggregates") |
| pubmed:22372633 | p(HGNC:HDAC6) increases bp(GO:"stress granule assembly") |
| pubmed:27181519 | p(HGNC:HDAC6) increases bp(GO:"stress granule assembly") |
| pubmed:22372633 | p(HGNC:HDAC6) decreases path(MESH:"Bulbo-Spinal Atrophy, X-Linked") |
| pubmed:22372633 | p(HGNC:HDAC6) decreases path(DOID:ciliopathy) |
| pubmed:22372633 | p(HGNC:HDAC6) increases p(CONSO:"alpha-synuclein aggregates") |
| pubmed:22372633 | p(HGNC:HDAC6) association bp(GO:autophagy) |
| pubmed:18930136 | p(HGNC:HDAC6) regulates bp(GO:autophagy) |
| pubmed:18930136 | p(HGNC:HDAC6) increases bp(GO:autophagy) |
| pubmed:22372633 | p(HGNC:HDAC6) positiveCorrelation bp(GO:"synaptic transmission, dopaminergic") |
| pubmed:22372633 | p(HGNC:HDAC6) negativeCorrelation path(DOID:"retinal degeneration") |
| pubmed:22372633 | p(HGNC:HDAC6) positiveCorrelation bp(MESH:Locomotion) |
| pubmed:22372633 | p(HGNC:HDAC6) increases p(HGNC:SNCA, loc(GO:"inclusion body")) |
| pubmed:22372633 | p(HGNC:HDAC6) negativeCorrelation bp(GO:"axonal transport") |
| pubmed:22372633 | p(HGNC:HDAC6) negativeCorrelation bp(GO:"axonal transport") |
| pubmed:22372633 | p(HGNC:HDAC6) causesNoChange path(DOID:"Huntington's disease") |
| pubmed:22372633 | p(HGNC:HDAC6) positiveCorrelation path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:30935091 | p(HGNC:HDAC6) decreases path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:27181519 | act(p(HGNC:HDAC6)) negativeCorrelation path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:22372633 | p(HGNC:HDAC6) positiveCorrelation path(MESH:"Muscle Denervation") |
| pubmed:22372633 | p(HGNC:HDAC6) decreases a(MESH:Axons) |
| pubmed:22372633 | p(HGNC:HDAC6) increases p(HGNC:HSPB1, var("?")) |
| pubmed:25546293 | p(HGNC:HDAC6) decreases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) |
| pubmed:25546293 | act(p(HGNC:HDAC6)) decreases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) |
| pubmed:25546293 | act(p(HGNC:HDAC6)) decreases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) |
| pubmed:25546293 | p(HGNC:HDAC6) decreases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) |
| pubmed:25546293 | p(HGNC:HDAC6) causesNoChange p(HGNC:CTNNB1) |
| pubmed:25546293 | p(HGNC:HDAC6) decreases p(HGNC:CTNNB1, loc(GO:"plasma membrane")) |
| pubmed:25546293 | act(p(HGNC:HDAC6)) decreases p(HGNC:CTNNB1, loc(GO:nucleus)) |
| pubmed:25546293 | act(p(HGNC:HDAC6)) decreases p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 45)) |
| pubmed:25546293 | act(p(HGNC:HDAC6)) causesNoChange p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 33)) |
| pubmed:25546293 | act(p(HGNC:HDAC6)) causesNoChange p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 37)) |
| pubmed:25546293 | act(p(HGNC:HDAC6)) causesNoChange p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 41)) |
| pubmed:25546293 | p(HGNC:HDAC6) decreases p(HGNC:HDAC6, pmod(go:0006473 ! "protein acetylation", Lys, 49)) |
| pubmed:25546293 | p(HGNC:HDAC6) decreases p(HGNC:HDAC6, pmod(go:0006473 ! "protein acetylation", Ser, 45)) |
| pubmed:30935091 | p(HGNC:HDAC6) increases path(MESH:"Nerve Degeneration") |
| pubmed:30935091 | p(HGNC:HDAC6) increases act(a(CHEBI:"kainic acid")) |
| pubmed:30935091 | p(HGNC:HDAC6) increases path(DOID:"axonal neuropathy") |
| pubmed:30935091 | p(HGNC:HDAC6) decreases p(HGNC:SOD1, pmod(CONSO:"protein aggregates"), var("p.Gly93Ala")) |
| pubmed:30935091 | p(HGNC:HDAC6) increases deg(p(HGNC:SOD1, pmod(CONSO:"protein aggregates"), var("p.Gly93Ala"), loc(GO:cytoplasm))) |
| pubmed:30935091 | act(p(HGNC:HDAC6)) increases p(CONSO:"Tau fibrils") |
| pubmed:30935091 | p(HGNC:HDAC6) decreases bp(GO:"learning or memory") |
| pubmed:30935091 | p(HGNC:HDAC6) decreases bp(GO:"learning or memory") |
| pubmed:30935091 | p(HGNC:HDAC6) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 369)) |
| pubmed:30935091 | p(HGNC:HDAC6) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:30935091 | p(HGNC:HDAC6) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30935091 | p(HGNC:HDAC6) decreases act(p(HGNC:AKT2)) |
| pubmed:30935091 | p(HGNC:HDAC6) decreases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:30935091 | p(HGNC:HDAC6) increases p(HGNC:HDAC6, pmod(CONSO:"protein aggregates")) |
| pubmed:30935091 | p(HGNC:HDAC6) association bp(GO:"response to oxidative stress") |
| pubmed:30935091 | p(HGNC:HDAC6) decreases p(HGNC:HSPB1) |
| pubmed:30935091 | p(HGNC:HDAC6) decreases p(HGNCGENEFAMILY:"Heat shock 70kDa proteins") |
| pubmed:30935091 | p(HGNC:HDAC6) positiveCorrelation path(MESH:Depression) |
| pubmed:30935091 | p(HGNC:HDAC6) decreases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006473 ! "protein acetylation", Lys, 49)) |
| pubmed:30935091 | p(HGNC:HDAC6) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation", Ser, 45)) |
| pubmed:30935091 | p(HGNC:HDAC6) causesNoChange p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation", Ser, 33)) |
| pubmed:30935091 | p(HGNC:HDAC6) causesNoChange p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation", Ser, 37)) |
| pubmed:30935091 | p(HGNC:HDAC6) causesNoChange p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation", Thr, 41)) |
| pubmed:30935091 | p(HGNC:HDAC6) decreases p(HGNCGENEFAMILY:"Beta catenins", loc(GO:"plasma membrane")) |
| pubmed:30935091 | p(HGNC:HDAC6) association bp(GO:"synapse assembly") |
| pubmed:30935091 | p(HGNC:HDAC6) decreases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30935091 | p(HGNC:HDAC6) decreases p(HGNC:AKT1, pmod(go:0006473 ! "protein acetylation", Lys, 163)) |
| pubmed:30935091 | p(HGNC:HDAC6) decreases p(HGNC:AKT1, pmod(go:0006473 ! "protein acetylation", Lys, 377)) |
| pubmed:30935091 | p(HGNC:HDAC6) decreases act(p(HGNC:AKT1), ma(GO:"phosphatidylinositol-3,4,5-trisphosphate binding")) |
| pubmed:29661268 | act(p(HGNC:HDAC6)) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser), loc(CONSO:"KXGS motif")) |
| pubmed:18930136 | p(HGNC:HDAC6) regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:18930136 | p(HGNC:HDAC6) regulates a(GO:aggresome) |
| pubmed:18930136 | p(HGNC:HDAC6) increases tloc(p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination")), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) |
| pubmed:18930136 | p(HGNC:HDAC6) increases bp(GO:"Hsp90 deacetylation") |
| pubmed:18930136 | p(HGNC:HDAC6) regulates complex(GO:"chaperone complex") |
| pubmed:18930136 | p(HGNC:HDAC6) increases bp(GO:"ubiquitin-dependent protein catabolic process") |
| pubmed:28803412 | p(HGNC:HDAC6) decreases a(CONSO:CONSO00093) |
| pubmed:30640040 | p(HGNC:HDAC6) association a(PUBCHEM:53340666) |
| pubmed:29311797 | p(HGNC:HDAC6) increases act(p(HGNC:AIP)) |
| pubmed:29311797 | p(HGNC:HDAC6) association a(CONSO:"Tau aggregates") |
| pubmed:26751493 | p(HGNC:HDAC6) association p(CONSO:"microtubule-binding region") |
| pubmed:26751493 | p(HGNC:HDAC6) association p(CONSO:"microtubule-binding region") |
| pubmed:26631930 | p(HGNC:HDAC6) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys)) |
| pubmed:23487739 | p(HGNC:HDAC6) decreases a(GO:microtubule) |
| pubmed:28760828 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) association p(CONSO:"Tau aggregates") |
| pubmed:25031639 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) decreases p(CONSO:"Tau aggregates") |
| pubmed:28760828 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) regulates act(p(HGNC:MARK2)) |
| pubmed:25031639 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) positiveCorrelation p(HGNC:EP300) |
| pubmed:25031639 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) decreases p(HGNC:MAPT, pmod(CONSO:"protein aggregates")) |
| pubmed:25031639 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) decreases p(HGNC:MAPT, pmod(CONSO:"Tau aggregates")) |
| pubmed:25031639 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) decreases path(EFO:"microtubule-associated protein tau") |
| pubmed:25031639 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) increases deg(complex(a(MESH:Microtubules), p(HGNC:MAPT))) |
| pubmed:25031639 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) increases a(MESH:Microtubules) |
| pubmed:25031639 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) increases bp(GO:"axonal transport") |
| pubmed:25031639 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) association p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30935091 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) decreases p(HGNC:MAPT) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) association p(HGNC:MAPT, var("p.Lys?Gln")) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) association p(HGNC:MAPT, var("p.Lys280Gln")) |
| pubmed:20869593 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:20869593 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24027553 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) association path(MESH:"Neurofibrillary Tangles") |
| pubmed:27041503 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) negativeCorrelation p(HGNC:WWC1) |
| pubmed:20869593 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) positiveCorrelation p(CONSO:"Tau epitope, AT8") |
| pubmed:28760828 | a(PUBCHEM:57381425) decreases act(p(HGNC:HDAC6)) |
| pubmed:30935091 | a(PUBCHEM:57381425) decreases p(HGNC:HDAC6) |
| pubmed:28760828 | a(PUBCHEM:57381425) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30935091 | a(PUBCHEM:57381425) increases bp(GO:"axonal transport") |
| pubmed:30935091 | a(PUBCHEM:57381425) positiveCorrelation bp(GO:"axonal transport") |
| pubmed:30935091 | a(PUBCHEM:57381425) positiveCorrelation bp(GO:"axonal transport") |
| pubmed:30935091 | a(PUBCHEM:57381425) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30935091 | a(PUBCHEM:57381425) increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30935091 | a(PUBCHEM:57381425) decreases path(MESH:"Amyloid Neuropathies") |
| pubmed:30935091 | a(PUBCHEM:57381425) increases bp(GO:"learning or memory") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 290), loc(CONSO:"KXGS motif")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser), pmod(go:0006468 ! "protein phosphorylation", Thr), loc(CONSO:"microtubule-binding region")) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 290), loc(CONSO:"KXGS motif")) decreases p(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 290)) increases deg(p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 290))) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 290)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 290)) decreases a(CONSO:"Tau aggregates") |
| pubmed:28760828 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 259), pmod(go:0006473 ! "protein acetylation", Gln, 290), pmod(go:0006473 ! "protein acetylation", Gln, 321), pmod(go:0006473 ! "protein acetylation", Gln, 353), var("p.Lys259Gln"), var("p.Lys290Gln"), var("p.Lys321Gln"), var("p.Lys352Gln")) negativeCorrelation p(CONSO:"Tau aggregates") |
| pubmed:28760828 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 290), pmod(go:0006473 ! "protein acetylation", Gln, 321), var("p.Lys290Gln"), var("p.Lys321Gln")) decreases p(CONSO:"Tau aggregates") |
| pubmed:28760828 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 321), var("p.Lys321Gln")) decreases p(CONSO:"Tau fibrils") |
| pubmed:21427723 | p(CONSO:"Tau fibrils") decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:22372633 | p(CONSO:"Tau fibrils") increases p(HGNC:HDAC6) |
| pubmed:22372633 | p(CONSO:"Tau fibrils") increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30108137 | p(CONSO:"Tau fibrils", loc(MESH:Lysosomes)) increases deg(p(CONSO:"Tau fibrils")) |
| pubmed:30108137 | p(CONSO:"Tau fibrils", loc(MESH:Lysosomes)) increases deg(p(CONSO:"Tau fibrils")) |
| pubmed:29238289 | p(CONSO:"Tau fibrils") increases tloc(p(HGNC:MAPT)) |
| pubmed:28760828 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 163), var("p.Lys163Gln")) causesNoChange p(CONSO:"Tau aggregates") |
| pubmed:28760828 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 174), var("p.Lys174Gln")) causesNoChange p(CONSO:"Tau aggregates") |
| pubmed:28760828 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 180), var("p.Lys180Gln")) causesNoChange p(CONSO:"Tau aggregates") |
| pubmed:28760828 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 234), var("p.Lys234Gln")) causesNoChange p(CONSO:"Tau aggregates") |
| pubmed:28760828 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 240), var("p.Lys240Gln")) causesNoChange p(CONSO:"Tau aggregates") |
| pubmed:28760828 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 274), var("p.Lys274Gln")) decreases p(CONSO:"Tau aggregates") |
| pubmed:28760828 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 280), var("p.Lys280Gln")) causesNoChange p(CONSO:"Tau aggregates") |
| pubmed:28760828 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 311), var("p.Lys311Gln")) causesNoChange p(CONSO:"Tau aggregates") |
| pubmed:28760828 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 369), var("p.Lys369Gln")) causesNoChange p(CONSO:"Tau aggregates") |
| pubmed:28760828 | p(HGNC:MAPT, var("p.Lys321Arg")) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:28760828 | p(HGNC:MAPT, var("p.Lys321Arg")) causesNoChange p(CONSO:"Tau fibrils") |
| pubmed:28760828 | p(HGNC:MAPT, var("p.Lys321Gln")) decreases p(CONSO:"Tau aggregates") |
| pubmed:28760828 | p(HGNC:MAPT, var("p.Lys321Gln")) decreases p(CONSO:"Tau fibrils") |
| pubmed:28760828 | composite(p(HGNC:MAPT), p(HGNC:MARK2)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) |
| pubmed:28760828 | composite(p(HGNC:MAPT), p(HGNC:MARK2)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) |
| pubmed:25374103 | composite(p(HGNC:MAPT), p(HGNC:MARK2)) positiveCorrelation bp(GO:"anterograde axonal transport") |
| pubmed:25031639 | p(HGNC:MARK2) increases p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25031639 | act(p(HGNC:MARK2)) increases p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25031639 | p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:29215007 | act(p(HGNC:MARK2), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:29215007 | p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:21311567 | act(p(HGNC:MARK2)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:24251416 | act(p(HGNC:MARK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:25031639 | p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:23001711 | act(p(HGNC:MARK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:25031639 | p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 365)) |
| pubmed:29215007 | act(p(HGNC:MARK2), ma(go:0016301 ! "kinase activity")) increases p(CONSO:CONSO00098, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29215007 | p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 293)) |
| pubmed:24251416 | act(p(HGNC:MARK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 293)) |
| pubmed:29215007 | p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 305)) |
| pubmed:24251416 | act(p(HGNC:MARK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 305)) |
| pubmed:29215007 | p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) |
| pubmed:24251416 | act(p(HGNC:MARK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) |
| pubmed:29215007 | p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) |
| pubmed:24251416 | act(p(HGNC:MARK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) |
| pubmed:25031639 | p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) |
| pubmed:29215007 | p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 416)) |
| pubmed:24251416 | act(p(HGNC:MARK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 416)) |
| pubmed:21882945 | act(p(HGNC:MARK2)) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21882945 | act(p(HGNC:MARK2)) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21311567 | act(p(HGNC:MARK2)) decreases bp(GO:"microtubule polymerization") |
| pubmed:24251416 | act(p(HGNC:MARK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 352)) |
| pubmed:24251416 | act(p(HGNC:MARK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 413)) |
| pubmed:28760828 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) increases p(CONSO:"Tau aggregates") |
| pubmed:17493042 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) decreases p(CONSO:"Tau aggregates") |
| pubmed:29215007 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pubmed:29215007 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) decreases bp(GO:"actin filament bundle assembly") |
| pubmed:17493042 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) |
| pubmed:17493042 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) decreases bp(GO:"neurofibrillary tangle assembly") |
| pubmed:30145931 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) positiveCorrelation a(CONSO:"amyloid-beta oligomers") |
| pubmed:30145931 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) positiveCorrelation a(CHEBI:wortmannin) |
| pubmed:30145931 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) positiveCorrelation a(CHEBI:epoxomicin) |
| pubmed:28760828 | composite(p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation"), var("p.Lys321Gln")), p(HGNC:MARK2)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) |
| pubmed:28760828 | composite(p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation"), var("p.Lys321Gln")), p(HGNC:MARK2)) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) |
| pubmed:21427723 | bp(GO:"microtubule polymerization") negativeCorrelation p(MGI:Mapt, var("p.Lys280del")) |
| pubmed:30061532 | bp(GO:"microtubule polymerization") increases bp(GO:"cytoskeleton organization") |
| pubmed:29238289 | bp(GO:"microtubule polymerization") association p(HGNC:MAPT) |
| pubmed:20133804 | bp(GO:"microtubule polymerization") positiveCorrelation complex(GO:microtubule) |
| pubmed:2123288 | bp(GO:"microtubule polymerization") increases a(MESH:Microtubules) |
| pubmed:28760828 | p(HGNC:MAPT, var("p.Ser324Ala")) increases bp(GO:"microtubule polymerization") |
| pubmed:28760828 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"), var("p.Ser324Asp")) decreases bp(GO:"microtubule polymerization") |
| pubmed:28760828 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"), var("p.Ser324Glu")) decreases bp(GO:"microtubule polymerization") |
| pubmed:28760828 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases bp(GO:"microtubule polymerization") |
| pubmed:25031639 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)), p(HGNC:STUB1)) |
| pubmed:25031639 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)), p(HGNC:STUB1)) |
| pubmed:25031639 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases deg(p(HGNC:MAPT)) |
| pubmed:22299660 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) increases bp(GO:autophagy) |
| pubmed:29215007 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pubmed:29215007 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases bp(GO:"actin filament bundle assembly") |
| pubmed:29215007 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases bp(GO:"actin filament bundle assembly") |
| pubmed:29215007 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_284"))) |
| pubmed:25374103 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) negativeCorrelation composite(p(CONSO:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases complex(p(HGNC:MAPT), p(HGNC:STUB1)) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356))) |
| pubmed:17493042 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) |
| pubmed:17493042 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases p(CONSO:"Tau aggregates") |
| pubmed:17493042 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases bp(GO:"neurofibrillary tangle assembly") |
| pubmed:21367866 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) positiveCorrelation p(HGNC:CDC37) |
| pubmed:11943212 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) association p(HGNC:MARK4, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22692785 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) partOf a(GO:"neurofibrillary tangle") |
| pubmed:22156579 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) partOf p(CONSO:"Tau epitope, 12E8") |
| pubmed:23948915 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) negativeCorrelation bp(GO:"apoptotic process") |
| pubmed:22833681 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:22952452 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) |
| pubmed:22952452 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) positiveCorrelation path(CONSO:Neurodegeneration) |
| pubmed:28760828 | p(HGNC:MAPT, var("p.Pro301Leu")) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:28760828 | p(HGNC:MAPT, var("p.Pro301Leu")) decreases deg(p(HGNC:MAPT)) |
| pubmed:29844403 | p(HGNC:MAPT, var("p.Pro301Leu")) increases p(HGNC:MAPT, loc(GO:cytosol)) |
| pubmed:29844403 | p(HGNC:MAPT, var("p.Pro301Leu")) increases p(HGNC:MAPT, loc(CONSO:"Tau aggregates")) |
| pubmed:29844403 | p(HGNC:MAPT, var("p.Pro301Leu")) increases p(HGNC:MAPT) |
| pubmed:28760828 | p(HGNC:MAPT, var("p.Pro301Leu")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) |
| pubmed:29844403 | p(HGNC:MAPT, var("p.Pro301Leu")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:29844403 | p(HGNC:MAPT, var("p.Pro301Leu")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:29844403 | p(HGNC:MAPT, var("p.Pro301Leu")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:29844403 | p(HGNC:MAPT, var("p.Pro301Leu")) increases complex(p(HGNC:HDAC6), p(HGNCGENEFAMILY:"Heat shock 90kDa proteins")) |
| pubmed:29844403 | p(HGNC:MAPT, var("p.Pro301Leu")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:29844403 | p(HGNC:MAPT, var("p.Pro301Leu")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:29844403 | p(HGNC:MAPT, var("p.Pro301Leu")) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:29844403 | p(HGNC:MAPT, var("p.Pro301Leu")) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) |
| pubmed:18583940 | p(HGNC:MAPT, var("p.Pro301Leu")) increases path(MESH:"Chromosome Aberrations") |
| pubmed:24027553 | p(HGNC:MAPT, var("p.Pro301Leu")) association path(MESH:"Frontotemporal Dementia") |
| pubmed:26751493 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pubmed:23294633 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Pro301Leu")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Pro301Leu")) increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Pro301Leu")) increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Pro301Leu")) decreases bp(GO:memory) |
| pubmed:29121589 | p(HGNC:MAPT, var("p.Pro301Leu")) increases r(MGI:Il1b) |
| pubmed:29121589 | p(HGNC:MAPT, var("p.Pro301Leu")) increases r(MGI:Nos2) |
| pubmed:23294633 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(MGI:Gsk3b, pmod(go:0006468 ! "protein phosphorylation", Tyr, 279)) |
| pubmed:23294633 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(MGI:Gsk3b, pmod(go:0006468 ! "protein phosphorylation", Tyr, 216)) |
| pubmed:23294633 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:23294633 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:23294633 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 212)) |
| pubmed:23294633 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 214)) |
| pubmed:23294633 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:11606569 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(CONSO:"VQIINK motif") |
| pubmed:11606569 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(CONSO:"VQIVYK motif") |
| pubmed:27716675 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation path(CONSO:neuroinflammation) |
| pubmed:28760828 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321)) decreases p(CONSO:"Tau aggregates") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321), loc(CONSO:"KXGS motif")) decreases p(CONSO:"Tau aggregates") |
| pubmed:28760828 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321), loc(CONSO:"KXGS motif")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324), loc(CONSO:"microtubule-binding region")) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321), loc(CONSO:"KXGS motif")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser), pmod(go:0006468 ! "protein phosphorylation", Thr), loc(CONSO:"microtubule-binding region")) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321)) increases deg(p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321))) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321)) decreases a(CONSO:"Tau aggregates") |
| pubmed:26192747 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321)) isA p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:26192747 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321)) partOf p(CONSO:"microtubule-binding region") |
| pubmed:21427723 | p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) increases p(CONSO:"Tau fibrils") |
| pubmed:21427723 | p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) association composite(p(MGI:Crebbp), p(MGI:Hdac6)) |
| pubmed:21427723 | p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) association p(MGI:Mapt, var("p.Lys280del")) |
| pubmed:21427723 | p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) decreases complex(a(MESH:Microtubules), p(MGI:Mapt)) |
| pubmed:21427723 | p(MGI:Mapt, frag("?")) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys)) |
| pubmed:21427723 | p(MGI:Mapt, frag("?")) positiveCorrelation bp(GO:"tubulin complex assembly") |
| pubmed:21427723 | p(MGI:Mapt, frag("?")) decreases p(CONSO:"Tau fibrils") |
| pubmed:21427723 | p(MGI:Crebbp) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:21427723 | p(MGI:Crebbp) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:21427723 | p(MGI:Crebbp) increases p(MGI:Mapt, frag("?"), pmod(go:0006473 ! "protein acetylation", Lys)) |
| pubmed:21427723 | p(MGI:Crebbp) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280), pmod(go:0006473 ! "protein acetylation", Lys, 281)) |
| pubmed:21427723 | p(MGI:Crebbp) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 163)) |
| pubmed:21427723 | p(MGI:Crebbp) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 396)) |
| pubmed:21427723 | bp(GO:"tubulin complex assembly") positiveCorrelation p(MGI:Mapt, frag("?")) |
| pubmed:21427723 | bp(GO:"tubulin complex assembly") negativeCorrelation p(MGI:Mapt, frag("?"), pmod(go:0006473 ! "protein acetylation")) |
| pubmed:21427723 | bp(GO:"tubulin complex assembly") negativeCorrelation p(MGI:Mapt, frag("?"), var("p.Lys311Asp")) |
| pubmed:21427723 | p(MGI:Mapt, frag("?"), pmod(go:0006473 ! "protein acetylation")) negativeCorrelation bp(GO:"tubulin complex assembly") |
| pubmed:21427723 | p(MGI:Mapt, frag("?"), pmod(go:0006473 ! "protein acetylation")) increases p(CONSO:"Tau fibrils") |
| pubmed:21427723 | p(MGI:Mapt, frag("?"), var("p.Lys311Asp")) negativeCorrelation bp(GO:"tubulin complex assembly") |
| pubmed:21427723 | p(MGI:Mapt, frag("?"), var("p.Lys311Asp")) decreases act(p(MGI:Mapt), ma(GO:"microtubule binding")) |
| pubmed:21427723 | p(MGI:Mapt, frag("?"), var("p.Lys311Asp")) decreases p(CONSO:"Tau fibrils") |
| pubmed:21427723 | a(CHEBI:"trichostatin A") decreases p(MESH:"Histone Deacetylases") |
| pubmed:21427723 | a(CHEBI:"trichostatin A") increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:27209302 | a(CHEBI:"trichostatin A") increases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:27209302 | a(CHEBI:"trichostatin A") decreases p(HGNC:HDAC1) |
| pubmed:27209302 | a(CHEBI:"trichostatin A") decreases p(HGNC:HDAC2) |
| pubmed:27209302 | a(CHEBI:"trichostatin A") decreases p(HGNC:HDAC4) |
| pubmed:27209302 | a(CHEBI:"trichostatin A") increases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation", Lys, 116)) |
| pubmed:27209302 | a(CHEBI:"trichostatin A") causesNoChange p(HGNC:TFEB, var("p.Lys116Arg")) |
| pubmed:27209302 | a(CHEBI:"trichostatin A") causesNoChange bp(GO:"microglial cell activation") |
| pubmed:21427723 | a(CHEBI:"trichostatin A") directlyDecreases act(p(FPLX:HDAC)) |
| pubmed:21427723 | a(CHEBI:"trichostatin A") increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:27209302 | p(MESH:"Histone Deacetylases") causesNoChange deg(p(HGNC:SIRT1)) |
| pubmed:21427723 | a(CHEBI:nicotinamide) decreases p(MGI:Sirt1) |
| pubmed:21427723 | a(CHEBI:nicotinamide) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:27209302 | a(CHEBI:nicotinamide) increases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:27209302 | a(CHEBI:nicotinamide) increases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:27209302 | a(CHEBI:nicotinamide) decreases p(HGNCGENEFAMILY:Sirtuins) |
| pubmed:27209302 | a(CHEBI:nicotinamide) increases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation", Lys, 116)) |
| pubmed:27209302 | a(CHEBI:nicotinamide) causesNoChange p(HGNC:TFEB, var("p.Lys116Arg")) |
| pubmed:27209302 | a(CHEBI:nicotinamide) decreases act(p(HGNC:SIRT1)) |
| pubmed:29540553 | p(MGI:Sirt1) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:29540553 | p(MGI:Sirt1) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 163)) |
| pubmed:29540553 | p(MGI:Sirt1) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 174)) |
| pubmed:29540553 | p(MGI:Sirt1) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 174)) |
| pubmed:29540553 | p(MGI:Sirt1) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 274)) |
| pubmed:29540553 | p(MGI:Sirt1) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:29540553 | p(MGI:Sirt1) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 369)) |
| pubmed:29540553 | p(MGI:Sirt1) causesNoChange p(MGI:Mapt, var("p.Pro301Ser")) |
| pubmed:29540553 | p(MGI:Sirt1) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 174), var("p.Pro301Ser")) |
| pubmed:29540553 | p(MGI:Sirt1) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 174), var("p.Pro301Ser")) |
| pubmed:29540553 | p(MGI:Sirt1) causesNoChange p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 274), var("p.Pro301Ser")) |
| pubmed:29540553 | p(MGI:Sirt1) decreases path(MESH:"Mortality, Premature") |
| pubmed:29540553 | p(MGI:Sirt1) causesNoChange p(MGI:Syp) |
| pubmed:29540553 | p(MGI:Sirt1) increases path(MESH:"Neuronal Plasticity") |
| pubmed:29540553 | p(MGI:Sirt1) causesNoChange p(MESH:"Neurofibrillary Tangles") |
| pubmed:29540553 | p(MGI:Sirt1) decreases path(EFO:"behavioural disinhibition measurement") |
| pubmed:29540553 | p(MGI:Sirt1) decreases path(EFO:tauopathy) |
| pubmed:29540553 | p(MGI:Sirt1) decreases a(MESH:Synapses) |
| pubmed:29540553 | p(MGI:Sirt1) increases bp(GO:behavior) |
| pubmed:29540553 | p(MGI:Sirt1) negativeCorrelation path(MESH:Tauopathies) |
| pubmed:21427723 | composite(a(CHEBI:"trichostatin A"), p(MGI:Crebbp)) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:21427723 | composite(p(MGI:Crebbp), p(MGI:Hdac6)) association p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:21427723 | p(MGI:Hdac6) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:21427723 | composite(p(MGI:Crebbp), p(MGI:Hdac6, var("?"))) causesNoChange p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:21427723 | p(MGI:Mapt, var("p.Lys163Arg"), var("p.Lys280Arg"), var("p.Lys281Arg"), var("p.Lys369Arg")) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:21427723 | p(MGI:Mapt, var("p.Lys163Arg"), var("p.Lys280Arg"), var("p.Lys281Arg"), var("p.Lys369Arg")) decreases act(p(MGI:Mapt)) |
| pubmed:21427723 | p(MGI:Mapt, var("p.Lys163Arg"), var("p.Lys280Arg"), var("p.Lys281Arg"), var("p.Lys369Arg")) negativeCorrelation bp(GO:"microtubule bundle formation") |
| pubmed:25031639 | a(MESH:Microtubules) positiveCorrelation p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:25031639 | a(MESH:Microtubules) negativeCorrelation act(p(HGNC:HDAC6)) |
| pubmed:25031639 | a(MESH:Microtubules) negativeCorrelation path(DOID:"Alzheimer's disease") |
| pubmed:25031639 | a(MESH:Microtubules) positiveCorrelation a(CHEBI:"epothilone D") |
| pubmed:22372633 | act(a(MESH:Microtubules)) association p(HGNC:TPPP) |
| pubmed:29238289 | a(MESH:Microtubules) association p(HGNC:MAPT) |
| pubmed:21427723 | bp(GO:"microtubule bundle formation") positiveCorrelation act(p(MGI:Mapt)) |
| pubmed:21427723 | bp(GO:"microtubule bundle formation") negativeCorrelation p(MGI:Mapt, var("p.Lys163Arg"), var("p.Lys280Arg"), var("p.Lys281Arg"), var("p.Lys369Arg")) |
| pubmed:21427723 | bp(GO:"microtubule bundle formation") negativeCorrelation p(MGI:Mapt, var("p.Lys280Arg")) |
| pubmed:21427723 | p(MGI:Mapt, var("p.Lys280Arg")) decreases act(p(MGI:Mapt)) |
| pubmed:21427723 | p(MGI:Mapt, var("p.Lys280Arg")) negativeCorrelation bp(GO:"microtubule bundle formation") |
| pubmed:21427723 | p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) regulates act(p(MGI:Mapt)) |
| pubmed:21427723 | p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation bp(GO:aging) |
| pubmed:21427723 | p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(CONSO:"4R tauopathy") |
| pubmed:21427723 | p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation complex(p(CONSO:"3R tau"), p(CONSO:"4R tau")) |
| pubmed:21427723 | p(MGI:Mapt, var("p.Lys280del")) association path(DOID:"frontotemporal dementia") |
| pubmed:21427723 | p(MGI:Mapt, var("p.Lys280del")) association path(DOID:tauopathy) |
| pubmed:21427723 | p(MGI:Mapt, var("p.Lys280del")) negativeCorrelation bp(GO:"microtubule polymerization") |
| pubmed:21427723 | p(MGI:Mapt, var("p.Lys280del")) increases p(CONSO:"paired helical filaments") |
| pubmed:21427723 | p(MGI:Mapt, var("p.Lys280del")) association p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:21427723 | path(DOID:"frontotemporal dementia") association p(MGI:Mapt, var("p.Lys280del")) |
| pubmed:29661268 | path(DOID:"frontotemporal dementia") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) |
| pubmed:29661268 | path(DOID:"frontotemporal dementia") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) |
| pubmed:29661268 | path(DOID:"frontotemporal dementia") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:30108137 | path(DOID:"frontotemporal dementia") increases r(HGNC:TFEB) |
| pubmed:30108137 | path(DOID:"frontotemporal dementia") increases r(HGNC:LAMP1) |
| pubmed:30108137 | path(DOID:"frontotemporal dementia") increases p(HGNC:LAMP1) |
| pubmed:30108137 | path(DOID:"frontotemporal dementia") increases p(HGNC:CTSD) |
| pubmed:18305152 | path(DOID:"frontotemporal dementia") association p(CONSO:"TDP-43 aggregates", loc(GO:cytoplasm)) |
| pubmed:21427723 | path(DOID:tauopathy) association p(MGI:Mapt, var("p.Lys280del")) |
| pubmed:25031639 | path(DOID:tauopathy) association bp(GO:"axonal transport") |
| pubmed:25031639 | path(DOID:tauopathy) positiveCorrelation p(HGNC:HDAC6) |
| pubmed:25031639 | path(DOID:tauopathy) increases p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25031639 | path(DOID:tauopathy) decreases p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:29661268 | path(DOID:tauopathy) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:29661268 | path(DOID:tauopathy) negativeCorrelation p(HGNC:STUB1) |
| pubmed:29661268 | path(DOID:tauopathy) negativeCorrelation p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:23516100 | path(DOID:tauopathy) positiveCorrelation p(HGNC:MAPT, frag("?")) |
| pubmed:23516100 | path(DOID:tauopathy) increases p(HGNC:MAPT, frag("?_*")) |
| pubmed:28148553 | path(DOID:tauopathy) association a(PUBCHEM:354398) |
| pubmed:28148553 | path(DOID:tauopathy) association p(MESH:"Neurofilament Proteins", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30108137 | path(DOID:tauopathy) increases p(HGNC:TFEB) |
| pubmed:30108137 | path(DOID:tauopathy) increases act(p(HGNC:TFEB)) |
| pubmed:30108137 | path(DOID:tauopathy) increases p(HGNC:TFEB, loc(GO:nucleus)) |
| pubmed:30108137 | path(DOID:tauopathy) increases p(HGNC:LAMP1) |
| pubmed:30108137 | path(DOID:tauopathy) increases p(HGNC:CTSD) |
| pubmed:26751493 | p(CONSO:"paired helical filaments") association p(HGNC:MAPT, var("p.Glu391*")) |
| pubmed:26751493 | p(CONSO:"paired helical filaments") partOf a(GO:"neurofibrillary tangle") |
| pubmed:17493042 | p(CONSO:"paired helical filaments") increases bp(GO:"neurofibrillary tangle assembly") |
| pubmed:21427723 | p(MGI:Mapt, var("p.Pro301Ser")) increases p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) |
| pubmed:28877763 | p(MGI:Mapt, var("p.Pro301Ser")) increases p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) |
| pubmed:28877763 | p(MGI:Mapt, var("p.Pro301Ser")) increases p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) |
| pubmed:29540553 | p(MGI:Mapt, var("p.Pro301Ser")) causesNoChange p(MGI:Syp) |
| pubmed:29540553 | p(MGI:Mapt, var("p.Pro301Ser")) decreases path(MESH:"Neuronal Plasticity") |
| pubmed:28877763 | p(MGI:Mapt, var("p.Pro301Ser")) increases a(CONSO:"Tau aggregates") |
| pubmed:30985105 | p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) negativeCorrelation p(MGI:Mapt, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:28877763 | p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) increases act(p(MGI:Syk)) |
| pubmed:28877763 | p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) increases a(CONSO:"Tau aggregates") |
| pubmed:26458742 | p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:19491104 | p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) association p(MGI:Mapk8ip1) |
| pubmed:19491104 | p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) negativeCorrelation act(p(MGI:Mapk8ip1)) |
| pubmed:19491104 | p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) negativeCorrelation act(p(MGI:Klc1)) |
| pubmed:19491104 | p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) negativeCorrelation complex(p(MGI:Klc1), p(MGI:Mapk8ip1)) |
| pubmed:26400044 | p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) increases complex(p(MGI:Dpysl2, pmod(go:0006468 ! "protein phosphorylation")), p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)), p(MGI:Wasf1, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:25143394 | p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) negativeCorrelation p(MGI:Ppp1ca) |
| pubmed:25143394 | p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) negativeCorrelation p(MGI:Ppp2ca) |
| pubmed:25143394 | p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) negativeCorrelation p(MGI:Ppp1cb) |
| pubmed:21427723 | p(MGI:App, var("p.Val717Phe")) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:29221819 | p(MGI:App) positiveCorrelation p(MGI:Dyrk1a) |
| pubmed:21427723 | p(GO:"neurofibrillary tangle") increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:23516100 | p(GO:"neurofibrillary tangle") negativeCorrelation bp(GO:behavior) |
| pubmed:21427723 | path(CONSO:"Corticobasal Degeneration") increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:30108137 | path(CONSO:"Corticobasal Degeneration") increases p(HGNC:TFEB) |
| pubmed:27574109 | path(CONSO:"Corticobasal Degeneration") association a(CONSO:"Tau oligomers") |
| pubmed:27574109 | path(CONSO:"Corticobasal Degeneration") positiveCorrelation a(CONSO:"Tau oligomers") |
| pubmed:27574109 | path(CONSO:"Corticobasal Degeneration") positiveCorrelation a(CONSO:"Tau oligomers") |
| pubmed:27574109 | path(CONSO:"Corticobasal Degeneration") association p(CONSO:"phosphatase-activating domain") |
| pubmed:27574109 | path(CONSO:"Corticobasal Degeneration") positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:27574109 | path(CONSO:"Corticobasal Degeneration") association p(HGNC:MAPT) |
| pubmed:27574109 | path(CONSO:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT) |
| pubmed:27574109 | path(CONSO:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT) |
| pubmed:27574109 | path(CONSO:"Corticobasal Degeneration") positiveCorrelation p(CONSO:"4R tau") |
| pubmed:26751493 | path(CONSO:"Corticobasal Degeneration") positiveCorrelation p(CONSO:"4R tau") |
| pubmed:26631930 | path(CONSO:"Corticobasal Degeneration") positiveCorrelation p(CONSO:"4R tau") |
| pubmed:27574109 | path(CONSO:"Corticobasal Degeneration") positiveCorrelation composite(p(CONSO:"phosphatase-activating domain"), p(HGNC:MAPT)) |
| pubmed:26631930 | path(CONSO:"Corticobasal Degeneration") isA path(MESH:Tauopathies) |
| pubmed:22057784 | path(CONSO:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) |
| pubmed:17050703 | path(CONSO:"Corticobasal Degeneration") association p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) |
| pubmed:21427723 | path(CONSO:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:21427723 | path(CONSO:"Corticobasal Degeneration") isA path(CONSO:"4R tauopathy") |
| pubmed:21427723 | path(DOID:"progressive supranuclear palsy") increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:28148553 | path(DOID:"progressive supranuclear palsy") increases p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | path(DOID:"progressive supranuclear palsy") increases p(HGNC:EIF2AK3) |
| pubmed:28148553 | path(DOID:"progressive supranuclear palsy") decreases p(HGNC:EIF2A) |
| pubmed:28148553 | path(DOID:"progressive supranuclear palsy") decreases p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | path(DOID:"progressive supranuclear palsy") increases p(HGNC:NFE2L2) |
| pubmed:28148553 | path(DOID:"progressive supranuclear palsy") increases p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21427723 | path(DOID:"amyotrophic lateral sclerosis") increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:22372633 | path(DOID:"amyotrophic lateral sclerosis") positiveCorrelation p(HGNC:HDAC6) |
| pubmed:27181519 | path(DOID:"amyotrophic lateral sclerosis") negativeCorrelation act(p(HGNC:HDAC6)) |
| pubmed:30935091 | path(DOID:"amyotrophic lateral sclerosis") association p(HGNC:FUS) |
| pubmed:30935091 | path(DOID:"amyotrophic lateral sclerosis") association p(HGNC:TARDBP) |
| pubmed:23384725 | path(DOID:"amyotrophic lateral sclerosis") association p(HGNC:TARDBP) |
| pubmed:30515821 | path(DOID:"amyotrophic lateral sclerosis") negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | path(DOID:"amyotrophic lateral sclerosis") increases bp(GO:"mitochondrial fission") |
| pubmed:30515821 | path(DOID:"amyotrophic lateral sclerosis") increases a(CHEBI:"reactive oxygen species") |
| pubmed:30515821 | path(DOID:"amyotrophic lateral sclerosis") increases act(p(HGNC:DNM1L)) |
| pubmed:21861815 | path(DOID:"amyotrophic lateral sclerosis") negativeCorrelation act(p(HGNC:VEGFA)) |
| pubmed:21861815 | path(DOID:"amyotrophic lateral sclerosis") negativeCorrelation act(p(NCIT:C13718)) |
| pubmed:21861815 | path(DOID:"amyotrophic lateral sclerosis") decreases p(HGNC:EPO) |
| pubmed:27181519 | path(DOID:"amyotrophic lateral sclerosis") isA path(MESH:"Motor Neuron Disease") |
| pubmed:27181519 | path(DOID:"amyotrophic lateral sclerosis") positiveCorrelation bp(GO:"motor neuron apoptotic process") |
| pubmed:27181519 | path(DOID:"amyotrophic lateral sclerosis") positiveCorrelation bp(GO:"muscle atrophy") |
| pubmed:27181519 | path(DOID:"amyotrophic lateral sclerosis") negativeCorrelation bp(CONSO:Proteostasis) |
| pubmed:27181519 | path(DOID:"amyotrophic lateral sclerosis") association g(HGNC:SOD1) |
| pubmed:27181519 | path(DOID:"amyotrophic lateral sclerosis") negativeCorrelation a(CHEBI:"all-trans-retinoic acid") |
| pubmed:27181519 | path(DOID:"amyotrophic lateral sclerosis") negativeCorrelation bp(GO:autophagy) |
| pubmed:27181519 | path(DOID:"amyotrophic lateral sclerosis") negativeCorrelation bp(GO:autophagy) |
| pubmed:27181519 | path(DOID:"amyotrophic lateral sclerosis") positiveCorrelation complex(GO:"cytoplasmic stress granule", loc(MESH:"Motor Neurons")) |
| pubmed:27181519 | path(DOID:"amyotrophic lateral sclerosis") positiveCorrelation p(HGNC:TARDBP, var("?")) |
| pubmed:27181519 | path(DOID:"amyotrophic lateral sclerosis") positiveCorrelation p(HGNC:FUS, var("?")) |
| pubmed:27181519 | path(DOID:"amyotrophic lateral sclerosis") association p(HGNC:MATR3) |
| pubmed:27181519 | path(DOID:"amyotrophic lateral sclerosis") association p(HGNC:HNRNPA2B1) |
| pubmed:27181519 | path(DOID:"amyotrophic lateral sclerosis") association p(HGNC:HNRNPA1) |
| pubmed:27181519 | path(DOID:"amyotrophic lateral sclerosis") association g(HGNC:C9orf72, var("?")) |
| pubmed:27181519 | path(DOID:"amyotrophic lateral sclerosis") association p(HGNC:OPTN) |
| pubmed:27181519 | path(DOID:"amyotrophic lateral sclerosis") association p(HGNC:OPTN, var("p.Glu478Gly")) |
| pubmed:27181519 | path(DOID:"amyotrophic lateral sclerosis") association p(HGNC:TBK1) |
| pubmed:27181519 | path(DOID:"amyotrophic lateral sclerosis") association p(HGNC:UBQLN2, var("?")) |
| pubmed:27181519 | path(DOID:"amyotrophic lateral sclerosis") association p(HGNC:OPTN, var("?")) |
| pubmed:27181519 | path(DOID:"amyotrophic lateral sclerosis") association p(HGNC:SQSTM1, var("?")) |
| pubmed:28669544 | path(DOID:"amyotrophic lateral sclerosis") increases p(HGNC:TARDBP, pmod(CONSO:"protein aggregation"), pmod(go:0016567 ! "protein ubiquitination"), loc(MESH:"Inclusion Bodies")) |
| pubmed:28669544 | path(DOID:"amyotrophic lateral sclerosis") negativeCorrelation a(MESH:"Motor Cortex") |
| pubmed:28669544 | path(DOID:"amyotrophic lateral sclerosis") increases p(HGNC:CD68) |
| pubmed:21427723 | path(CONSO:"4R tauopathy") association path(DOID:"Alzheimer's disease") |
| pubmed:21427723 | path(CONSO:"4R tauopathy") positiveCorrelation p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:21427723 | path(CONSO:"4R tauopathy") association p(CONSO:"4R tau") |
| pubmed:21427723 | complex(p(CONSO:"3R tau"), p(CONSO:"4R tau")) association path(DOID:"Alzheimer's disease") |
| pubmed:21427723 | complex(p(CONSO:"3R tau"), p(CONSO:"4R tau")) positiveCorrelation p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:21427723 | p(CONSO:"3R tau") association path(DOID:"Niemann-Pick disease") |
| pubmed:21427723 | p(CONSO:"3R tau") causesNoChange p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:12428809 | p(CONSO:"3R tau") increases a(CONSO:"straight filaments") |
| pubmed:28148553 | p(CONSO:"3R tau") decreases p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | p(CONSO:"3R tau") causesNoChange a(CONSO:"Tau antibody, MC1") |
| pubmed:27574109 | p(CONSO:"3R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pubmed:27574109 | p(CONSO:"3R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pubmed:27574109 | p(CONSO:"3R tau") positiveCorrelation bp(GO:"positive regulation of protein oligomerization") |
| pubmed:27574109 | p(CONSO:"3R tau") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26631930 | p(CONSO:"3R tau") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27574109 | p(CONSO:"3R tau") positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pubmed:26655600 | p(CONSO:"3R tau", loc(GO:"Pick body")) positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pubmed:26751493 | p(CONSO:"3R tau") positiveCorrelation path(MESH:"Niemann-Pick Diseases") |
| pubmed:26631930 | p(CONSO:"3R tau") positiveCorrelation path(MESH:"Niemann-Pick Diseases") |
| pubmed:23407988 | p(CONSO:"3R tau") isA p(HGNC:MAPT) |
| pubmed:23407988 | p(CONSO:"3R tau") partOf complex(GO:"neurofibrillary tangle") |
| pubmed:23407988 | p(CONSO:"3R tau") partOf a(CONSO:"ghost tangles") |
| pubmed:23407988 | p(CONSO:"3R tau") partOf a(CONSO:"Brodmann (1909) area 36") |
| pubmed:23407988 | p(CONSO:"3R tau") partOf a(CONSO:"CA1 field of hippocampus") |
| pubmed:23407988 | p(CONSO:"3R tau") partOf a(CONSO:"CA2 field of hippocampus") |
| pubmed:23407988 | p(CONSO:"3R tau") partOf a(CONSO:"CA3 field of hippocampus") |
| pubmed:23407988 | p(CONSO:"3R tau") partOf a(CONSO:"CA4 field of hippocampus") |
| pubmed:23407988 | p(CONSO:"3R tau") partOf complex(GO:dendrite) |
| pubmed:23407988 | p(CONSO:"3R tau") partOf a(MESH:Neuropil) |
| pubmed:23407988 | p(CONSO:"3R tau") partOf complex(GO:"neuronal cell body") |
| pubmed:26655600 | p(CONSO:"3R tau") causesNoChange a(CONSO:"Tau aggregates") |
| pubmed:28775333 | p(CONSO:"3R tau") positiveCorrelation p(MGI:Dyrk1a) |
| pubmed:12428809 | p(CONSO:"4R tau") increases path(MESH:"Wallerian Degeneration") |
| pubmed:12428809 | p(CONSO:"4R tau") increases path(MESH:"Muscular Atrophy") |
| pubmed:12428809 | p(CONSO:"4R tau") increases path(HP:Neurodegeneration) |
| pubmed:12428809 | p(CONSO:"4R tau") positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pubmed:26751493 | p(CONSO:"4R tau") positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pubmed:12428809 | p(CONSO:"4R tau") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27574109 | p(CONSO:"4R tau") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26631930 | p(CONSO:"4R tau") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:28148553 | p(CONSO:"4R tau") decreases p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | p(CONSO:"4R tau") causesNoChange a(CONSO:"Tau antibody, MC1") |
| pubmed:27574109 | p(CONSO:"4R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pubmed:27574109 | p(CONSO:"4R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pubmed:27574109 | p(CONSO:"4R tau") positiveCorrelation bp(GO:"positive regulation of protein oligomerization") |
| pubmed:27574109 | p(CONSO:"4R tau") positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pubmed:27574109 | p(CONSO:"4R tau") positiveCorrelation path(CONSO:"Corticobasal Degeneration") |
| pubmed:26751493 | p(CONSO:"4R tau") positiveCorrelation path(CONSO:"Corticobasal Degeneration") |
| pubmed:26631930 | p(CONSO:"4R tau") positiveCorrelation path(CONSO:"Corticobasal Degeneration") |
| pubmed:26751493 | p(CONSO:"4R tau") positiveCorrelation path(CONSO:"Argyrophilic Grain Disease") |
| pubmed:26751493 | p(CONSO:"4R tau") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pubmed:26631930 | p(CONSO:"4R tau") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pubmed:23407988 | p(CONSO:"4R tau") isA p(HGNC:MAPT) |
| pubmed:23407988 | p(CONSO:"4R tau") partOf a(CONSO:pretangles) |
| pubmed:23407988 | p(CONSO:"4R tau") partOf complex(GO:"neurofibrillary tangle") |
| pubmed:23407988 | p(CONSO:"4R tau") positiveCorrelation a(CONSO:"CA4 field of hippocampus") |
| pubmed:23407988 | p(CONSO:"4R tau") positiveCorrelation a(CONSO:"CA3 field of hippocampus") |
| pubmed:23407988 | p(CONSO:"4R tau") positiveCorrelation a(CONSO:"CA2 field of hippocampus") |
| pubmed:23407988 | p(CONSO:"4R tau") positiveCorrelation a(CONSO:"CA1 field of hippocampus") |
| pubmed:23407988 | p(CONSO:"4R tau") positiveCorrelation a(CONSO:"Brodmann (1909) area 36") |
| pubmed:23407988 | p(CONSO:"4R tau") partOf complex(GO:"neuronal cell body") |
| pubmed:23407988 | p(CONSO:"4R tau") partOf complex(GO:dendrite) |
| pubmed:23407988 | p(CONSO:"4R tau") partOf a(MESH:Neuropil) |
| pubmed:28775333 | p(CONSO:"4R tau") negativeCorrelation p(MGI:Dyrk1a) |
| pubmed:21427723 | p(CONSO:"4R tau") association path(CONSO:"4R tauopathy") |
| pubmed:27574109 | p(CONSO:"4R tau") positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:21427723 | path(DOID:"Niemann-Pick disease") association p(CONSO:"3R tau") |
| pubmed:29661268 | path(DOID:"Niemann-Pick disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) |
| pubmed:29661268 | path(DOID:"Niemann-Pick disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) |
| pubmed:29661268 | path(DOID:"Niemann-Pick disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:23516100 | path(DOID:"Niemann-Pick disease") increases p(HGNC:MAPT, frag("1_421")) |
| pubmed:23516100 | path(DOID:"Niemann-Pick disease") increases p(HGNC:TARDBP, frag("?")) |
| pubmed:25031639 | p(HGNC:MAPT, frag("?"), pmod(go:0006473 ! "protein acetylation", Lys, 18)) increases p(HGNC:MAPT, frag("?"), pmod(CONSO:"protein aggregates"), pmod(go:0006473 ! "protein acetylation", Lys, 18)) |
| pubmed:29844403 | p(MESH:"Neurofibrillary Tangles") increases path(HP:"Abnormal synaptic transmission") |
| pubmed:31248781 | p(MESH:"Neurofibrillary Tangles") association path(CONSO:Neurodegeneration) |
| pubmed:25031639 | bp(GO:"axonal transport") negativeCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:29844403 | bp(GO:"axonal transport") negativeCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:25031639 | bp(GO:"axonal transport") negativeCorrelation p(CONSO:"Tau aggregates") |
| pubmed:25031639 | bp(GO:"axonal transport") negativeCorrelation path(DOID:"Alzheimer's disease") |
| pubmed:25031639 | bp(GO:"axonal transport") association path(DOID:tauopathy) |
| pubmed:22372633 | bp(GO:"axonal transport") negativeCorrelation p(HGNC:HDAC6) |
| pubmed:22372633 | bp(GO:"axonal transport") negativeCorrelation p(HGNC:HDAC6) |
| pubmed:30935091 | bp(GO:"axonal transport") positiveCorrelation a(PUBCHEM:57381425) |
| pubmed:30935091 | bp(GO:"axonal transport") positiveCorrelation a(PUBCHEM:57381425) |
| pubmed:30935091 | bp(GO:"axonal transport") positiveCorrelation a(PUBCHEM:57382288) |
| pubmed:30935091 | bp(GO:"axonal transport") negativeCorrelation path(DOID:"Charcot-Marie-Tooth disease") |
| pubmed:30935091 | bp(GO:"axonal transport") negativeCorrelation p(HGNC:GARS, var("?")) |
| pubmed:30935091 | bp(GO:"axonal transport") positiveCorrelation a(PUBCHEM:49850262) |
| pubmed:30935091 | bp(GO:"axonal transport") positiveCorrelation a(PUBCHEM:49850262) |
| pubmed:30935091 | bp(GO:"axonal transport") negativeCorrelation p(HGNC:FUS, var("?")) |
| pubmed:30515821 | bp(GO:"axonal transport") positiveCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | bp(GO:"axonal transport") negativeCorrelation composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) |
| pubmed:30515821 | bp(GO:"axonal transport") negativeCorrelation composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:30515821 | bp(GO:"axonal transport") negativeCorrelation complex(p(HGNC:DNM1L), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) |
| pubmed:30515821 | bp(GO:"axonal transport") positiveCorrelation complex(p(HGNC:DNM1L, var("p.Lys38Ala")), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) |
| pubmed:30515821 | bp(GO:"axonal transport") negativeCorrelation act(p(HGNC:DNM1L), ma(GO:"GTPase activity")) |
| pubmed:12428809 | bp(GO:"axonal transport") association p(HGNC:MAPT) |
| pubmed:12428809 | bp(GO:"axonal transport") association p(HGNC:APP) |
| pubmed:12428809 | bp(GO:"axonal transport") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | bp(GO:"axonal transport") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:12428809 | bp(GO:"axonal transport") association a(CHEBI:amyloid-beta) |
| pubmed:12428809 | bp(GO:"axonal transport") association p(HGNC:GSK3B) |
| pubmed:21722302 | bp(GO:"axonal transport") association bp(GO:"motor neuron apoptotic process") |
| pubmed:26631930 | bp(GO:"axonal transport") decreases path(CONSO:Neurodegeneration) |
| pubmed:21734277 | bp(GO:"axonal transport") negativeCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:25031639 | bp(GO:"synaptic signaling") negativeCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:25031639 | bp(GO:"synaptic signaling") negativeCorrelation p(CONSO:"Tau aggregates") |
| pubmed:29428175 | bp(GO:"synaptic signaling") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:23384725 | bp(GO:"synaptic signaling") association p(HGNC:TARDBP) |
| pubmed:30988501 | bp(GO:"synaptic signaling") association a(MESH:Microglia) |
| pubmed:25031639 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(DOID:"Alzheimer's disease") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(DOID:"Alzheimer's disease") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(DOID:"frontotemporal dementia") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(DOID:"Niemann-Pick disease") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) decreases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination", Lys, 280)) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation bp(GO:"microtubule severing") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280), loc(CONSO:"microtubule-binding region")) increases bp(GO:"microtubule severing") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) increases p(CONSO:"paired helical filaments") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280), loc(CONSO:"microtubule-binding region")) increases p(CONSO:"Tau fibrils") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) decreases deg(p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280))) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29276758 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21427723 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(MESH:"Niemann-Pick Diseases") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pubmed:29276758 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) decreases a(MESH:Neurons) |
| pubmed:29276758 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(MESH:"Chronic Traumatic Encephalopathy") |
| pubmed:26940749 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:26940749 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) increases path(CONSO:Neurodegeneration) |
| pubmed:26192747 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) isA p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:26192747 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) partOf p(CONSO:"microtubule-binding region") |
| pubmed:21427723 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(CONSO:"Corticobasal Degeneration") |
| pubmed:25031639 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) decreases complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)), p(HGNC:STUB1)) |
| pubmed:29215007 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pubmed:29215007 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) decreases bp(GO:"actin filament bundle assembly") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) decreases complex(p(HGNC:MAPT), p(HGNC:STUB1)) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) decreases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262))) |
| pubmed:17493042 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) |
| pubmed:17493042 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) decreases p(CONSO:"Tau aggregates") |
| pubmed:17493042 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) decreases bp(GO:"neurofibrillary tangle assembly") |
| pubmed:21367866 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) positiveCorrelation p(HGNC:CDC37) |
| pubmed:22156579 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) partOf p(CONSO:"Tau epitope, 12E8") |
| pubmed:22833681 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:25031639 | p(CONSO:"Tau epitope, 12E8") partOf p(CONSO:"KXGS motif") |
| pubmed:25031639 | p(CONSO:"Tau epitope, 12E8") partOf p(CONSO:"KXGS motif") |
| pubmed:22156579 | p(CONSO:"Tau epitope, 12E8") positiveCorrelation p(CONSO:"Tau epitope, PHF1") |
| pubmed:25031639 | p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) increases path(MESH:Tauopathies) |
| pubmed:25031639 | p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) increases p(MESH:"Neurofibrillary Tangles") |
| pubmed:25031639 | p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) decreases complex(p(HGNC:MAPT), p(HGNC:STUB1)) |
| pubmed:25031639 | p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:"Heat shock 70kDa proteins")) |
| pubmed:25031639 | p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:"Heat shock 90kDa proteins")) |
| pubmed:25031639 | p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) increases p(CONSO:"Tau aggregates") |
| pubmed:25031639 | p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) increases p(CONSO:"Tau aggregates", loc(MESH:"Neurofibrillary Tangles")) |
| pubmed:25031639 | p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) |
| pubmed:25031639 | p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) decreases p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:25031639 | p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) increases deg(complex(a(MESH:Microtubules), p(HGNC:MAPT))) |
| pubmed:25031639 | p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) association p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:25031639 | p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) association p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:25031639 | p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) increases path(DOID:tauopathy) |
| pubmed:25031639 | p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) increases a(GO:"neurofibrillary tangle") |
| pubmed:18986241 | path(MESH:Tauopathies) association p(HGNC:CHRM1) |
| pubmed:24653673 | path(MESH:Tauopathies) negativeCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pubmed:24653673 | path(MESH:Tauopathies) negativeCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pubmed:29758300 | path(MESH:Tauopathies) association p(HGNC:MAPT) |
| pubmed:29758300 | path(MESH:Tauopathies) association path(MESH:Dementia) |
| pubmed:29758300 | path(MESH:Tauopathies) positiveCorrelation p(HGNC:BIN1) |
| pubmed:30145931 | path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:29024336 | path(MESH:Tauopathies) increases path(MESH:"Proteostasis Deficiencies") |
| pubmed:24027553 | path(MESH:Tauopathies) positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pubmed:24027553 | path(MESH:Tauopathies) association p(HGNC:NPEPPS) |
| pubmed:27574109 | path(MESH:Tauopathies) positiveCorrelation a(CONSO:"Tau oligomers") |
| pubmed:29686391 | path(MESH:Tauopathies) positiveCorrelation a(CONSO:"Tau oligomers") |
| pubmed:27574109 | path(MESH:Tauopathies) positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:21734277 | path(MESH:Tauopathies) association p(CONSO:"Tau epitope, AT8", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30108137 | path(MESH:Tauopathies) association act(p(MGI:Tfeb)) |
| pubmed:30108137 | path(MESH:Tauopathies) increases p(MGI:Tfeb) |
| pubmed:30108137 | path(MESH:Tauopathies) increases p(MGI:Tfeb) |
| pubmed:30108137 | path(MESH:Tauopathies) increases p(MGI:Lamp1) |
| pubmed:30108137 | path(MESH:Tauopathies) increases p(MGI:Ctsd) |
| pubmed:21882945 | path(MESH:Tauopathies) positiveCorrelation bp(GO:"neuron death") |
| pubmed:28420982 | path(MESH:Tauopathies) association bp(GO:"neuron death") |
| pubmed:21882945 | path(MESH:Tauopathies) negativeCorrelation bp(GO:cognition) |
| pubmed:30126037 | path(MESH:Tauopathies) association bp(GO:"cellular senescence") |
| pubmed:30126037 | path(MESH:Tauopathies) association path(MESH:"Supranuclear Palsy, Progressive") |
| pubmed:22419736 | path(MESH:Tauopathies) association a(CONSO:"amyloid-beta 42 oligomers") |
| pubmed:29191965 | path(MESH:Tauopathies) association p(HGNC:WNT2) |
| pubmed:29191965 | path(MESH:Tauopathies) association p(HGNC:TTBK2) |
| pubmed:29191965 | path(MESH:Tauopathies) association p(HGNC:GSK3B) |
| pubmed:29191965 | path(MESH:Tauopathies) association p(HGNC:TAOK1) |
| pubmed:29191965 | path(MESH:Tauopathies) association p(HGNC:CTSE) |
| pubmed:29191965 | path(MESH:Tauopathies) association p(HGNC:CHRNA7) |
| pubmed:28420982 | path(MESH:Tauopathies) association a(CONSO:"Tau annular protofibrils") |
| pubmed:26631930 | path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) |
| pubmed:26631930 | path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) |
| pubmed:26631930 | path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) |
| pubmed:26631930 | path(MESH:Tauopathies) increases p(HGNC:MAPT, frag("?")) |
| pubmed:29980653 | path(MESH:Tauopathies) isA path(MESH:"Neurodegenerative Diseases") |
| pubmed:29980653 | path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, var("?")) |
| pubmed:29540553 | path(MESH:Tauopathies) negativeCorrelation p(MGI:Sirt1) |
| pubmed:25031639 | complex(p(HGNC:MAPT), p(HGNC:STUB1)) increases deg(p(HGNC:MAPT)) |
| pubmed:25031639 | complex(p(HGNC:MAPT), p(HGNC:STUB1)) increases deg(p(HGNC:MAPT)) |
| pubmed:25031639 | complex(p(HGNC:MAPT), p(HGNC:STUB1)) increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:25031639 | p(HGNC:STUB1) increases complex(p(HGNC:MAPT), p(HGNC:STUB1)) |
| pubmed:25031639 | p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:29661268 | p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:29661268 | p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:29661268 | p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:29661268 | p(HGNC:STUB1) regulates p(HGNC:MAPT) |
| pubmed:29661268 | p(HGNC:STUB1) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:25374103 | p(HGNC:STUB1) increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) |
| pubmed:29661268 | p(HGNC:STUB1) negativeCorrelation bp(GO:"neuron death") |
| pubmed:29661268 | p(HGNC:STUB1) negativeCorrelation p(CONSO:"Tau aggregates") |
| pubmed:29661268 | act(p(HGNC:STUB1)) increases p(CONSO:"Tau aggregates") |
| pubmed:29661268 | p(HGNC:STUB1) negativeCorrelation path(DOID:tauopathy) |
| pubmed:29661268 | act(p(HGNC:STUB1)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27491084 | p(HGNC:STUB1) decreases path(HP:Neurodegeneration) |
| pubmed:27491084 | p(HGNC:STUB1) decreases p(HGNC:ATXN3, var("?")) |
| pubmed:27491084 | p(HGNC:STUB1) decreases p(HGNC:HTT, var("?")) |
| pubmed:22908190 | p(HGNC:STUB1) increases complex(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)), p(HGNC:STUB1)) |
| pubmed:25036637 | p(HGNC:STUB1) increases complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pubmed:25036637 | p(HGNC:STUB1) directlyIncreases complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) |
| pubmed:25036637 | p(HGNC:STUB1) directlyIncreases complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pubmed:25036637 | p(HGNC:STUB1) regulates bp(GO:"cellular protein catabolic process") |
| pubmed:24027553 | p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(go:0070936 ! "protein K48-linked ubiquitination")) |
| pubmed:26631930 | p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(go:0070936 ! "protein K48-linked ubiquitination")) |
| pubmed:24027553 | p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(go:0070534 ! "protein K63-linked ubiquitination")) |
| pubmed:23528736 | p(HGNC:STUB1) association path(MESH:"Neurodegenerative Diseases") |
| pubmed:23528736 | p(HGNC:STUB1) association path(MESH:"Alzheimer Disease") |
| pubmed:29311797 | p(HGNC:STUB1) association path(MESH:"Alzheimer Disease") |
| pubmed:21882945 | act(p(HGNC:STUB1)) increases bp(GO:"protein catabolic process") |
| pubmed:21882945 | act(p(HGNC:STUB1)) increases bp(GO:"protein ubiquitination") |
| pubmed:25374103 | p(HGNC:STUB1) regulates act(p(HGNC:CASP3)) |
| pubmed:25374103 | p(HGNC:STUB1) increases deg(p(CONSO:"Tau C3")) |
| pubmed:25374103 | p(HGNC:STUB1) decreases p(CONSO:"Tau C3") |
| pubmed:25374103 | p(HGNC:STUB1) increases deg(p(CONSO:"Tau C3")) |
| pubmed:25374103 | p(HGNC:STUB1) causesNoChange bp(GO:"cell death") |
| pubmed:25374103 | p(HGNC:STUB1) increases complex(p(HGNC:HSPA8), p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")), p(HGNC:STUB1)) |
| pubmed:25374103 | p(HGNC:STUB1) increases deg(p(CONSO:"4R tau", var("p.Lys280del"))) |
| pubmed:25374103 | p(HGNC:STUB1) decreases act(p(FPLX:Caspase)) |
| pubmed:25374103 | p(HGNC:STUB1) increases deg(p(FPLX:Caspase)) |
| pubmed:29311797 | p(HGNC:STUB1) association path(MESH:"Huntington Disease") |
| pubmed:29311797 | p(HGNC:STUB1) association path(MESH:"Parkinson Disease") |
| pubmed:29311797 | p(HGNC:STUB1) association path(MESH:"Cystic Fibrosis") |
| pubmed:29311797 | p(HGNC:STUB1) association path(MESH:Neoplasms) |
| pubmed:14612456 | p(HGNC:STUB1) isA complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:STUB1), p(HGNC:UBE2D2)) |
| pubmed:27325702 | p(HGNC:STUB1) association p(CONSO:"APP, ACR") |
| pubmed:27325702 | p(HGNC:STUB1) isA complex(GO:"ubiquitin ligase complex") |
| pubmed:25031639 | complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:"Heat shock 70kDa proteins")) increases deg(p(HGNC:MAPT)) |
| pubmed:30935091 | p(HGNCGENEFAMILY:"Heat shock 70kDa proteins") decreases bp(MESH:"Oxidative Stress") |
| pubmed:30935091 | p(HGNCGENEFAMILY:"Heat shock 70kDa proteins") increases bp(MESH:"Cell Survival") |
| pubmed:29661268 | p(HGNCGENEFAMILY:"Heat shock 70kDa proteins") negativeCorrelation p(CONSO:"Tau aggregates") |
| pubmed:25031639 | complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:"Heat shock 90kDa proteins")) increases deg(p(HGNC:MAPT)) |
| pubmed:22372633 | act(p(HGNCGENEFAMILY:"Heat shock 90kDa proteins"), ma(GO:"vascular endothelial growth factor receptor 1 binding")) increases act(p(HGNCGENEFAMILY:"Heat shock 70kDa proteins"), ma(GO:"vascular endothelial growth factor receptor 1 binding")) |
| pubmed:22372633 | act(p(HGNCGENEFAMILY:"Heat shock 90kDa proteins"), ma(GO:"vascular endothelial growth factor receptor 2 binding")) increases act(p(HGNCGENEFAMILY:"Heat shock 70kDa proteins"), ma(GO:"vascular endothelial growth factor receptor 2 binding")) |
| pubmed:29844403 | p(HGNCGENEFAMILY:"Heat shock 90kDa proteins") association p(HGNC:HDAC6) |
| pubmed:25031639 | a(MESH:"Histone Deacetylase Inhibitors") increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:25031639 | a(MESH:"Histone Deacetylase Inhibitors") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25031639 | p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) decreases p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25031639 | p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) decreases p(CONSO:"Tau aggregates") |
| pubmed:25031639 | p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) decreases p(CONSO:"Tau aggregates") |
| pubmed:25031639 | p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25031639 | p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) increases deg(p(HGNC:MAPT)) |
| pubmed:25031639 | p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) decreases path(DOID:tauopathy) |
| pubmed:25031639 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 365)) decreases complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)), p(HGNC:STUB1)) |
| pubmed:25031639 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) increases deg(p(HGNC:MAPT)) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) increases p(HGNC:MAPT) |
| pubmed:8391280 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination"), loc(CONSO:"paired helical filaments")) increases deg(p(HGNC:MAPT)) |
| pubmed:25378699 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) increases deg(p(HGNC:MAPT)) |
| pubmed:25031639 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) negativeCorrelation bp(GO:"proteasomal protein catabolic process") |
| pubmed:25031639 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) negativeCorrelation bp(GO:"lysosomal protein catabolic process") |
| pubmed:25031639 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) increases p(MESH:"Neurofibrillary Tangles") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"), loc(CONSO:"KXGS motif")) |
| pubmed:14612456 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) positiveCorrelation path(DOID:"Alzheimer's disease") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) negativeCorrelation path(DOID:tauopathy) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) increases act(p(MESH:"Proteasome Endopeptidase Complex")) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) decreases act(p(MESH:"Proteasome Endopeptidase Complex")) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) increases p(CONSO:"Tau aggregates") |
| pubmed:22908190 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24027553 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) association path(MESH:"Neurofibrillary Tangles") |
| pubmed:14612456 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) positiveCorrelation p(HGNC:UBE2D2) |
| pubmed:24905733 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) |
| pubmed:25031639 | complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)), p(HGNCGENEFAMILY:"Heat shock 90kDa proteins")) increases deg(p(HGNC:MAPT)) |
| pubmed:25031639 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) increases complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)), p(HGNCGENEFAMILY:"Heat shock 90kDa proteins")) |
| pubmed:22299660 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22419736 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:28420982 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26458742 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22611162 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) association p(HGNC:MAPT, var("p.Val277Met")) |
| pubmed:28420982 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pubmed:14612456 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) isA p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:20071522 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) isA p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:20071522 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) association complex(p(HGNC:FKBP5), p(HGNC:MAPT)) |
| pubmed:20071522 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) positiveCorrelation p(HGNC:FKBP5) |
| pubmed:21367866 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) positiveCorrelation p(HGNC:CDC37) |
| pubmed:22764226 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) negativeCorrelation p(MGI:Ppp2ca, pmod(go:0006479 ! "protein methylation")) |
| pubmed:17078951 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) positiveCorrelation p(FPLX:PKA) |
| pubmed:22156579 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) positiveCorrelation p(CONSO:"Tau epitope, PHF1") |
| pubmed:25331948 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) partOf p(CONSO:"Tau epitope, PHF1") |
| pubmed:22833681 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) partOf p(CONSO:"Tau epitope, PHF1") |
| pubmed:23948915 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) negativeCorrelation bp(GO:"apoptotic process") |
| pubmed:19459590 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) |
| pubmed:22833681 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:25031639 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) increases complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)), p(HGNC:STUB1)) |
| pubmed:25031639 | complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)), p(HGNCGENEFAMILY:"Heat shock 90kDa proteins")) increases deg(p(HGNC:MAPT)) |
| pubmed:25031639 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) increases complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)), p(HGNCGENEFAMILY:"Heat shock 90kDa proteins")) |
| pubmed:22299660 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22419736 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26458742 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22611162 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) association p(HGNC:MAPT, var("p.Val277Met")) |
| pubmed:24760868 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) increases p(HGNC:MAPT, loc(MESH:"Dendritic Spines")) |
| pubmed:14612456 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) isA p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21367866 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) positiveCorrelation p(HGNC:CDC37) |
| pubmed:22764226 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) negativeCorrelation p(MGI:Ppp2ca, pmod(go:0006479 ! "protein methylation")) |
| pubmed:17078951 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) negativeCorrelation p(FPLX:PKA) |
| pubmed:11943212 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) partOf p(CONSO:"Tau epitope, AD2") |
| pubmed:22156579 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) positiveCorrelation p(CONSO:"Tau epitope, PHF1") |
| pubmed:25331948 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) partOf p(CONSO:"Tau epitope, PHF1") |
| pubmed:22833681 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) partOf p(CONSO:"Tau epitope, PHF1") |
| pubmed:19459590 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) |
| pubmed:25031639 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) increases complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)), p(HGNC:STUB1)) |
| pubmed:25031639 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation), pmod(go:0016567 ! "protein ubiquitination")) increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation), pmod(go:0016567 ! "protein ubiquitination")) increases p(CONSO:"Tau aggregates") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation), pmod(go:0016567 ! "protein ubiquitination")) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:25031639 | bp(GO:"lysosomal protein catabolic process") negativeCorrelation p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:21722302 | bp(GO:"lysosomal protein catabolic process") increases deg(p(MESH:Proteins, pmod(CONSO:misfolded))) |
| pubmed:27209302 | bp(GO:"lysosomal protein catabolic process") increases deg(p(CONSO:"amyloid-beta oligomers")) |
| pubmed:29758300 | bp(GO:"lysosomal protein catabolic process") decreases a(GO:autolysosome) |
| pubmed:29758300 | bp(GO:"lysosomal protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | bp(GO:"lysosomal protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | bp(GO:"lysosomal protein catabolic process") positiveCorrelation bp(GO:autophagy) |
| pubmed:22908190 | bp(GO:"lysosomal protein catabolic process") positiveCorrelation bp(GO:autophagy) |
| pubmed:22908190 | bp(GO:"lysosomal protein catabolic process") negativeCorrelation act(p(HGNC:RAB5A)) |
| pubmed:22908190 | bp(GO:"lysosomal protein catabolic process") increases bp(GO:"axonal transport") |
| pubmed:22908190 | bp(GO:"lysosomal protein catabolic process") negativeCorrelation bp(GO:endocytosis) |
| pubmed:22908190 | bp(GO:"lysosomal protein catabolic process") decreases path(CONSO:Neurodegeneration) |
| pubmed:22908190 | bp(GO:"lysosomal protein catabolic process") decreases path(CONSO:Neurodegeneration) |
| pubmed:22908190 | bp(GO:"lysosomal protein catabolic process") decreases p(HGNC:MAP1LC3B) |
| pubmed:22908190 | bp(GO:"lysosomal protein catabolic process") decreases p(HGNC:SQSTM1) |
| pubmed:22908190 | bp(GO:"lysosomal protein catabolic process") decreases p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:22908190 | bp(GO:"lysosomal protein catabolic process") increases deg(a(MESH:"Amyloid beta-Peptides")) |
| pubmed:22908190 | bp(GO:"lysosomal protein catabolic process") increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:22908190 | bp(GO:"lysosomal protein catabolic process") increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:22908190 | bp(GO:"lysosomal protein catabolic process") decreases a(CHEBI:amyloid-beta) |
| pubmed:22908190 | bp(GO:"lysosomal protein catabolic process") increases bp(GO:learning) |
| pubmed:22908190 | bp(GO:"lysosomal protein catabolic process") increases bp(GO:memory) |
| pubmed:25031639 | p(HGNC:MAPT, pmod(CONSO:"Tau aggregates"), pmod(go:0016567 ! "protein ubiquitination")) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:25031639 | act(complex(GO:microtubule), ma(GO:"microtubule motor activity")) negativeCorrelation act(p(HGNC:HDAC6)) |
| pubmed:25031639 | act(complex(GO:microtubule), ma(GO:"microtubule motor activity")) negativeCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:6543144 | complex(GO:microtubule) association complex(complex(GO:neurofilament), p(HGNC:MAPT)) |
| pubmed:10464280 | act(complex(GO:microtubule)) positiveCorrelation p(CONSO:"microtubule-binding region") |
| pubmed:10464280 | complex(GO:microtubule) association p(HGNC:PPP2CA) |
| pubmed:10464280 | complex(GO:microtubule) association p(HGNC:MAPT) |
| pubmed:10464280 | act(complex(GO:microtubule)) directlyDecreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:18500754 | act(complex(GO:microtubule)) negativeCorrelation act(p(HGNC:HSPA8)) |
| pubmed:18500754 | complex(GO:microtubule) association p(INTERPRO:"Heat shock protein 70 family") |
| pubmed:20133804 | complex(GO:microtubule) positiveCorrelation bp(GO:"microtubule polymerization") |
| pubmed:25031639 | g(HGNC:HDAC6) positiveCorrelation bp(GO:cognition) |
| pubmed:25031639 | g(HGNC:HDAC6) causesNoChange path(MESH:"Plaque, Amyloid") |
| pubmed:25031639 | composite(p(HGNC:HDAC6), p(HGNC:SOD1, var("?"))) decreases path(MESH:Neuroprotection) |
| pubmed:25031639 | composite(p(HGNC:HDAC6), p(HGNC:SOD1, var("?"))) decreases bp(MESH:"Cell Survival") |
| pubmed:25031639 | composite(p(HGNC:HDAC6), p(HGNC:SOD1, var("?"))) decreases bp(GO:"motor neuron axon guidance") |
| pubmed:30688256 | p(HGNC:SOD1, var("?")) association bp(GO:mitophagy) |
| pubmed:30688256 | p(HGNC:SOD1, var("?")) increases bp(GO:mitophagy) |
| pubmed:30688256 | p(HGNC:SOD1, var("?")) increases act(p(HGNC:PRKN)) |
| pubmed:30688256 | p(HGNC:SOD1, var("?")) increases deg(p(HGNC:RHOT1)) |
| pubmed:30688256 | p(HGNC:SOD1, var("?")) decreases bp(GO:"retrograde axonal transport of mitochondrion") |
| pubmed:21722302 | p(HGNC:SOD1, var("?")) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:21722302 | p(HGNC:SOD1, var("?")) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:14556719 | p(HGNC:SOD1, var("?")) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30985105 | p(HGNC:SOD1, var("?")) increases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:21722302 | p(HGNC:SOD1, var("?")) increases bp(MESH:"Unfolded Protein Response") |
| pubmed:21722302 | p(HGNC:SOD1, var("?")) increases p(MESH:"Molecular Chaperones") |
| pubmed:21722302 | p(HGNC:SOD1, var("?")) increases bp(MESH:"Endoplasmic Reticulum Stress") |
| pubmed:14556719 | p(HGNC:SOD1, var("?")) increases bp(GO:"response to oxidative stress") |
| pubmed:14556719 | p(HGNC:SOD1, var("?")) increases bp(GO:"response to oxidative stress") |
| pubmed:14556719 | p(HGNC:SOD1, var("?")) increases bp(GO:"cell death") |
| pubmed:14556719 | p(HGNC:SOD1, var("?")) negativeCorrelation act(complex(GO:"proteasome complex")) |
| pubmed:14556719 | p(HGNC:SOD1, var("?")) increases act(complex(GO:"proteasome complex")) |
| pubmed:18930136 | p(HGNC:SOD1, var("?")) association p(HGNC:SQSTM1) |
| pubmed:27181519 | p(HGNC:SOD1, var("?")) association bp(GO:autophagy) |
| pubmed:30837838 | p(HGNC:SOD1, var("?")) increases p(HGNC:TARDBP, frag("274_414")) |
| pubmed:25031639 | p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) positiveCorrelation a(MESH:Microtubules) |
| pubmed:22372633 | p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) increases a(MESH:Microtubules) |
| pubmed:25031639 | p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) positiveCorrelation bp(GO:"microtubule cytoskeleton organization") |
| pubmed:25031639 | p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) association p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22372633 | p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) positiveCorrelation bp(GO:"axonal transport of mitochondrion") |
| pubmed:22372633 | p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) decreases bp(GO:"microtubule depolymerization") |
| pubmed:25031639 | a(CHEBI:"epothilone D") positiveCorrelation a(MESH:Microtubules) |
| pubmed:25031639 | a(CHEBI:"epothilone D") increases a(MESH:Microtubules, loc(MESH:Axons)) |
| pubmed:25031639 | a(CHEBI:"epothilone D") positiveCorrelation bp(GO:cognition) |
| pubmed:30116051 | a(CHEBI:"epothilone D") increases bp(GO:cognition) |
| pubmed:25031639 | a(CHEBI:"epothilone D") decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:30116051 | a(CHEBI:"epothilone D") increases a(GO:microtubule) |
| pubmed:25031639 | bp(GO:"microtubule cytoskeleton organization") positiveCorrelation p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:18583940 | bp(GO:"microtubule cytoskeleton organization") decreases path(MESH:"Neurodegenerative Diseases") |
| pubmed:24173717 | bp(GO:"microtubule cytoskeleton organization") negativeCorrelation p(HGNC:TUBB6) |
| pubmed:30606258 | bp(GO:"microtubule cytoskeleton organization") increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation", Lys, 40)) |
| pubmed:25031639 | deg(complex(a(MESH:Microtubules), p(HGNC:MAPT))) regulates p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:25031639 | deg(complex(a(MESH:Microtubules), p(HGNC:MAPT))) regulates p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:2446784 | complex(a(MESH:Microtubules), p(HGNC:MAPT)) association p(HGNC:MAPT) |
| pubmed:25031639 | p(HGNC:MAPT, pmod(CONSO:misfolded), loc(GO:"dendrite terminus")) increases bp(GO:"anterograde dendritic transport") |
| pubmed:25031639 | p(HGNC:MAPT, pmod(CONSO:misfolded), loc(GO:"dendrite terminus")) increases bp(GO:"retrograde dendritic transport") |
| pubmed:25031639 | p(HGNC:MAPT, pmod(CONSO:misfolded), loc(GO:"axon terminus")) increases bp(GO:"anterograde axonal transport") |
| pubmed:25031639 | p(HGNC:MAPT, pmod(CONSO:misfolded), loc(GO:"axon terminus")) increases bp(GO:"retrograde axonal transport") |
| pubmed:25031639 | tloc(p(HGNC:MAPT, pmod(CONSO:misfolded)), fromLoc(GO:cytoplasm), toLoc(MESH:Neurons)) increases path(DOID:tauopathy) |
| pubmed:25031639 | p(HGNC:MAPT, pmod(CONSO:misfolded), loc(MESH:Neurons)) increases path(DOID:tauopathy) |
| pubmed:28877763 | p(HGNC:MAPT, pmod(CONSO:misfolded)) positiveCorrelation act(p(HGNC:SYK)) |
| pubmed:29311797 | p(HGNC:MAPT, pmod(CONSO:misfolded)) increases bp(GO:"cell death in response to oxidative stress") |
| pubmed:16566606 | p(HGNC:MAPT, pmod(CONSO:misfolded)) association p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) |
| pubmed:16566606 | p(HGNC:MAPT, pmod(CONSO:misfolded)) association p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) |
| pubmed:16566606 | p(HGNC:MAPT, pmod(CONSO:misfolded)) association p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) |
| pubmed:16566606 | p(HGNC:MAPT, pmod(CONSO:misfolded)) association p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) |
| pubmed:25031639 | bp(GO:"anterograde dendritic transport") increases tloc(p(HGNC:MAPT, pmod(CONSO:misfolded)), fromLoc(GO:cytoplasm), toLoc(MESH:Neurons)) |
| pubmed:25031639 | bp(GO:"retrograde dendritic transport") increases tloc(p(HGNC:MAPT, pmod(CONSO:misfolded)), fromLoc(GO:cytoplasm), toLoc(MESH:Neurons)) |
| pubmed:25031639 | bp(GO:"anterograde axonal transport") increases tloc(p(HGNC:MAPT, pmod(CONSO:misfolded)), fromLoc(GO:cytoplasm), toLoc(MESH:Neurons)) |
| pubmed:23516100 | bp(GO:"anterograde axonal transport") negativeCorrelation p(HGNC:MAPT, frag("?"), pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25374103 | bp(GO:"anterograde axonal transport") decreases a(MESH:Mitochondria) |
| pubmed:25374103 | bp(GO:"anterograde axonal transport") positiveCorrelation composite(p(HGNC:MAPT), p(HGNC:MARK2)) |
| pubmed:25031639 | bp(GO:"retrograde axonal transport") increases tloc(p(HGNC:MAPT, pmod(CONSO:misfolded)), fromLoc(GO:cytoplasm), toLoc(MESH:Neurons)) |
| pubmed:30027901 | bp(GO:"retrograde axonal transport") increases tloc(a(MESH:Autophagosomes), fromLoc(GO:"distal axon"), toLoc(GO:"cell body")) |
| pubmed:25031639 | p(HGNC:MAPT, var("p.Pro301Ser")) increases path(DOID:tauopathy) |
| pubmed:28148553 | p(HGNC:MAPT, var("p.Pro301Ser")) decreases p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | p(HGNC:MAPT, var("p.Pro301Ser")) increases p(HGNC:EIF2AK3) |
| pubmed:28148553 | p(HGNC:MAPT, var("p.Pro301Ser")) increases p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | p(HGNC:MAPT, var("p.Pro301Ser")) increases p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | p(HGNC:MAPT, var("p.Pro301Ser")) increases path(EFO:"memory impairment") |
| pubmed:28148553 | p(HGNC:MAPT, var("p.Pro301Ser")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"), var("p.Pro301Ser")) |
| pubmed:28148553 | p(HGNC:MAPT, var("p.Pro301Ser")) negativeCorrelation path(MESH:"Protein Conformation") |
| pubmed:28148553 | p(HGNC:MAPT, var("p.Pro301Ser")) negativeCorrelation bp(GO:"dendritic spine maintenance") |
| pubmed:28148553 | p(HGNC:MAPT, var("p.Pro301Ser")) negativeCorrelation path(MESH:Locomotion) |
| pubmed:28148553 | p(HGNC:MAPT, var("p.Pro301Ser")) increases a(CONSO:"paired helical filaments") |
| pubmed:28148553 | p(HGNC:MAPT, var("p.Pro301Ser")) negativeCorrelation a(FMA:83664) |
| pubmed:28148553 | p(HGNC:MAPT, var("p.Pro301Ser")) negativeCorrelation a(MESH:"Motor Neurons") |
| pubmed:28148553 | p(HGNC:MAPT, var("p.Pro301Ser")) negativeCorrelation a(MESH:"Spinal Cord Ventral Horn") |
| pubmed:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases path(MESH:"Frontotemporal Dementia") |
| pubmed:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) |
| pubmed:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) |
| pubmed:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) |
| pubmed:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) |
| pubmed:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:"early endosome") |
| pubmed:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:"late endosome") |
| pubmed:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:lysosome) |
| pubmed:24406748 | p(HGNC:MAPT, var("p.Pro301Ser")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:24406748 | p(HGNC:MAPT, var("p.Pro301Ser")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:24406748 | p(HGNC:MAPT, var("p.Pro301Ser")) decreases path(MESH:Cognition) |
| pubmed:24406748 | p(HGNC:MAPT, var("p.Pro301Ser")) increases path(CONSO:"mitochondrial dysfunction") |
| pubmed:24406748 | p(HGNC:MAPT, var("p.Pro301Ser")) decreases bp(GO:"axonal transport") |
| pubmed:22372633 | p(HGNC:TPPP) association act(a(MESH:Microtubules)) |
| pubmed:22372633 | p(HGNC:TPPP) association bp(GO:"cell motility") |
| pubmed:22372633 | bp(GO:"cell motility") association p(HGNC:TPPP) |
| pubmed:22372633 | complex(p(HGNC:HDAC6), p(HGNC:TPPP)) decreases act(p(HGNC:HDAC6), ma(GO:"deacetylase activity")) |
| pubmed:22372633 | complex(p(HGNC:HDAC6), p(HGNC:MAPT)) decreases act(p(HGNC:HDAC6), ma(GO:"deacetylase activity")) |
| pubmed:29661268 | complex(p(HGNC:HDAC6), p(HGNC:MAPT)) increases act(p(HGNC:HDAC6)) |
| pubmed:22372633 | p(HGNC:SIRT2) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:22372633 | bp(GO:"axonal transport of mitochondrion") negativeCorrelation p(HGNC:HDAC6) |
| pubmed:30935091 | bp(GO:"axonal transport of mitochondrion") negativeCorrelation p(HGNC:HDAC6) |
| pubmed:22372633 | bp(GO:"axonal transport of mitochondrion") positiveCorrelation p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:22372633 | bp(GO:"axonal transport of mitochondrion") positiveCorrelation composite(a(MESH:Microtubules), p(MESH:Dyneins), p(MESH:Kinesin)) |
| pubmed:30837838 | bp(GO:"axonal transport of mitochondrion") negativeCorrelation p(HGNC:TARDBP, var("?")) |
| pubmed:22372633 | composite(a(MESH:Microtubules), p(MESH:Dyneins), p(MESH:Kinesin)) positiveCorrelation bp(GO:"axonal transport of mitochondrion") |
| pubmed:22372633 | p(MESH:Dyneins) causesNoChange p(HGNC:HDAC6) |
| pubmed:22372633 | p(MESH:Dyneins) increases bp(GO:"stress granule assembly") |
| pubmed:22372633 | bp(GO:"microtubule depolymerization") positiveCorrelation p(HGNC:HDAC6) |
| pubmed:26323690 | bp(GO:"microtubule depolymerization") negativeCorrelation p(HGNC:KIF2A, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22372633 | p(HGNC:MAPRE1) increases bp(MESH:Growth) |
| pubmed:25297623 | p(HGNC:MAPRE1) partOf complex(p(HGNC:MAPRE1), p(HGNC:TTBK2)) |
| pubmed:25297623 | p(HGNC:MAPRE1) association p(HGNC:TTBK2) |
| pubmed:22372633 | p(HGNC:ACTR1A) increases bp(MESH:Growth) |
| pubmed:22372633 | a(CHEBI:"growth hormone") increases p(HGNC:HDAC6, loc(GO:membrane)) |
| pubmed:22372633 | complex(p(HGNC:CTTN), p(HGNC:HDAC6)) decreases p(HGNC:CTTN, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:22372633 | act(p(HGNC:CTTN), ma(GO:"actin filament binding")) association p(HGNC:CTTN, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:22372633 | p(HGNC:CTTN) increases bp(GO:"actin filament reorganization") |
| pubmed:22372633 | act(p(HGNC:CTTN), ma(GO:"actin filament binding")) increases bp(GO:"actin filament reorganization") |
| pubmed:22372633 | p(HGNC:CTTN) increases bp(GO:"actin filament organization") |
| pubmed:22372633 | act(p(HGNC:CTTN), ma(GO:"actin filament binding")) regulates bp(GO:"actin filament organization") |
| pubmed:22372633 | p(HGNC:CTTN, pmod(go:0006473 ! "protein acetylation")) association act(p(HGNC:CTTN), ma(GO:"actin filament binding")) |
| pubmed:22372633 | bp(GO:"actin filament reorganization") increases bp(GO:"autophagosome-lysosome fusion") |
| pubmed:22372633 | p(HGNC:PRX, pmod(go:0006473 ! "protein acetylation")) increases act(p(HGNC:PRX), ma(GO:"antioxidant activity")) |
| pubmed:22372633 | p(HGNC:HSF1) increases p(HGNCGENEFAMILY:"Heat shock 90kDa proteins") |
| pubmed:30837838 | p(HGNC:HSF1) increases p(HGNCGENEFAMILY:"Heat shock 90kDa proteins") |
| pubmed:27491084 | p(HGNC:HSF1) increases bp(CONSO:Proteostasis) |
| pubmed:21882945 | p(HGNC:HSF1) increases bp(CONSO:Proteostasis) |
| pubmed:23746257 | p(HGNC:HSF1) regulates bp(GO:"cellular response to stress") |
| pubmed:23746257 | p(HGNC:HSF1) increases a(MESH:"Molecular Chaperones") |
| pubmed:25784053 | act(p(HGNC:HSF1), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases a(MESH:"Molecular Chaperones") |
| pubmed:23746257 | p(HGNC:HSF1) decreases a(MESH:"Protein Aggregates") |
| pubmed:25784053 | act(p(HGNC:HSF1)) increases tloc(p(HGNC:HSF1), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pubmed:25784053 | act(p(HGNC:HSF1)) association path(MESH:Neoplasms) |
| pubmed:24563850 | p(HGNC:HSF1) increases a(MESH:"Heat-Shock Proteins") |
| pubmed:21882945 | p(HGNC:HSF1) increases a(MESH:"Heat-Shock Proteins") |
| pubmed:30116051 | act(p(HGNC:HSF1), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(FPLX:HSPA)) |
| pubmed:30837838 | p(HGNC:HSF1) increases p(HGNCGENEFAMILY:"Heat shock 70kDa proteins") |
| pubmed:30837838 | p(HGNC:HSF1) decreases p(CONSO:"TDP-43 aggregates") |
| pubmed:22372633 | complex(p(HGNC:HDAC6), p(HGNC:HSF1), p(HGNCGENEFAMILY:"Heat shock 90kDa proteins")) decreases act(p(HGNC:HSF1)) |
| pubmed:30640040 | act(p(HGNC:FLT1)) increases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | act(p(HGNC:KDR)) increases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | p(HGNC:KDR) association a(PUBCHEM:11154925) |
| pubmed:30640040 | p(HGNC:KDR) association a(PUBCHEM:11234052) |
| pubmed:29844403 | p(HGNCGENEFAMILY:"Heat shock 90kDa proteins", pmod(go:0006473 ! "protein acetylation")) increases deg(p(HGNC:MAPT)) |
| pubmed:29844403 | p(HGNCGENEFAMILY:"Heat shock 90kDa proteins", pmod(go:0006473 ! "protein acetylation")) decreases complex(p(HGNC:HDAC6), p(HGNCGENEFAMILY:"Heat shock 90kDa proteins")) |
| pubmed:23516100 | p(CONSO:"protein aggregates") increases act(p(HGNCGENEFAMILY:Caspases)) |
| pubmed:30108137 | p(CONSO:"protein aggregates") association act(p(HGNC:TFEB)) |
| pubmed:27181519 | p(CONSO:"protein aggregates") association bp(GO:"cell death") |
| pubmed:28669544 | deg(p(CONSO:"protein aggregates")) increases path(MESH:Phagocytosis) |
| pubmed:22372633 | complex(p(HGNC:HSF1), p(HGNCGENEFAMILY:"Heat shock 90kDa proteins")) increases p(MESH:Proteins, pmod(CONSO:misfolded), pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:22372633 | p(HGNC:VCP) decreases bp(GO:"protein ubiquitination") |
| pubmed:24457024 | p(HGNC:VCP) increases bp(GO:"protein ubiquitination") |
| pubmed:22908190 | act(p(HGNC:VCP)) regulates bp(GO:"ERAD pathway") |
| pubmed:22908190 | act(p(HGNC:VCP)) regulates a(GO:autophagosome) |
| pubmed:27181519 | p(HGNC:VCP) decreases a(GO:autophagosome) |
| pubmed:24457024 | p(HGNC:VCP) increases bp(GO:"proteasomal protein catabolic process") |
| pubmed:27181519 | p(HGNC:VCP) decreases complex(GO:"cytoplasmic stress granule") |
| pubmed:27181519 | p(HGNC:VCP) increases complex(GO:"cytoplasmic stress granule", loc(GO:autophagosome)) |
| pubmed:27181519 | p(HGNC:VCP) increases complex(GO:"cytoplasmic stress granule", loc(GO:autophagosome)) |
| pubmed:27181519 | p(HGNC:VCP) increases bp(GO:autophagy) |
| pubmed:27181519 | p(HGNC:VCP) decreases p(HGNC:TARDBP) |
| pubmed:27181519 | p(HGNC:VCP) increases bp(GO:"stress granule assembly") |
| pubmed:30837838 | p(HGNC:VCP) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:22372633 | bp(GO:"protein ubiquitination") increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:14556719 | bp(GO:"protein ubiquitination") regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:22372633 | bp(GO:"protein ubiquitination") increases p(CONSO:"protein aggregates") |
| pubmed:14556719 | bp(GO:"protein ubiquitination") increases bp(GO:"lysosomal protein catabolic process") |
| pubmed:14556719 | bp(GO:"protein ubiquitination") increases bp(GO:"protein catabolic process in the vacuole") |
| pubmed:18930136 | bp(GO:"protein ubiquitination") regulates bp(GO:autophagy) |
| pubmed:22372633 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(MESH:Proteins)) |
| pubmed:22372633 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation bp(GO:"stress granule assembly") |
| pubmed:22372633 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(DOID:"neurodegenerative disease") |
| pubmed:29661268 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(DOID:"Alzheimer's disease") |
| pubmed:29661268 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:29661268 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation), pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:29661268 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:MAPT)) |
| pubmed:30116051 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:MAPT)) |
| pubmed:23528736 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association deg(p(HGNC:MAPT)) |
| pubmed:23528736 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") regulates deg(p(HGNC:MAPT)) |
| pubmed:25374103 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:MAPT)) |
| pubmed:30515821 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:DNM1, pmod(go:0016567 ! "protein ubiquitination"))) |
| pubmed:30027901 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(MESH:Proteins, pmod(CONSO:misfolded))) |
| pubmed:29758300 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(CONSO:Neurodegeneration) |
| pubmed:18930136 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(CONSO:Neurodegeneration) |
| pubmed:29758300 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases path(MESH:Tauopathies) |
| pubmed:29758300 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association a(CONSO:"Tau aggregates") |
| pubmed:23528736 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association a(CONSO:"Tau aggregates") |
| pubmed:29758300 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") causesNoChange deg(a(CONSO:"protein aggregates")) |
| pubmed:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases a(CONSO:"protein aggregates") |
| pubmed:27181519 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") causesNoChange deg(a(CONSO:"protein aggregates")) |
| pubmed:29758300 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SNCA)) |
| pubmed:18930136 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SNCA)) |
| pubmed:18930136 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SNCA)) |
| pubmed:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Parkinson Disease") |
| pubmed:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:PARK7)) |
| pubmed:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23528736 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Prion Diseases") |
| pubmed:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Prion Diseases") |
| pubmed:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation bp(GO:aging) |
| pubmed:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases p(HGNC:PRNP, loc(MESH:Cytoplasm)) |
| pubmed:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:PRNP)) |
| pubmed:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SOD1, var("?"))) |
| pubmed:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SOD1, var("?"))) |
| pubmed:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SOD1, var("?"))) |
| pubmed:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:HTT, frag("?"))) |
| pubmed:22908190 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"))) |
| pubmed:22908190 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association bp(GO:"regulation of synaptic plasticity") |
| pubmed:30116051 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"regulation of synaptic plasticity") |
| pubmed:22908190 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association bp(GO:learning) |
| pubmed:22908190 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association bp(GO:memory) |
| pubmed:30116051 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:memory) |
| pubmed:22908190 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:ARC)) |
| pubmed:22908190 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"long-term memory") |
| pubmed:18930136 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") regulates bp(GO:"amino acid homeostasis") |
| pubmed:18930136 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"cellular protein catabolic process") |
| pubmed:29626319 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"cellular protein catabolic process") |
| pubmed:18930136 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases rxn(reactants(a(MESH:Proteins)), products(a(CHEBI:oligopeptide))) |
| pubmed:18930136 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"ubiquitin recycling") |
| pubmed:18930136 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation bp(GO:autophagy) |
| pubmed:18930136 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases tloc(p(HGNC:WDFY3), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) |
| pubmed:30116051 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"dendrite development") |
| pubmed:23528736 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association path(HP:Neurodegeneration) |
| pubmed:29626319 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") regulates deg(a(MESH:Proteins)) |
| pubmed:29626319 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases act(p(HGNC:UBA1)) |
| pubmed:29626319 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases act(p(FPLX:UBE2)) |
| pubmed:29626319 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases act(p(MESH:"Ubiquitin-Protein Ligases")) |
| pubmed:29626319 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases act(p(HGNC:PSMD7)) |
| pubmed:29626319 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases p(CONSO:"Tau oligomers", pmod(CONSO:hyperphosphorylation)) |
| pubmed:27708431 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:MARK4)) |
| pubmed:27181519 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") causesNoChange bp(GO:"ribonucleoprotein complex disassembly") |
| pubmed:22372633 | complex(p(HGNC:HDAC6), p(MESH:Dyneins)) increases complex(a(MESH:Dyneins), p(CONSO:"protein aggregates")) |
| pubmed:18930136 | a(MESH:Dyneins) increases bp(GO:"autophagosome-lysosome fusion") |
| pubmed:26631930 | act(a(MESH:Dyneins)) association p(HGNC:MAPT) |
| pubmed:30061532 | p(HGNC:MAP1LC3A) increases bp(GO:"autophagosome assembly") |
| pubmed:30061532 | p(HGNC:MAP1LC3A) increases bp(GO:"autophagosome maturation") |
| pubmed:30027901 | p(HGNC:MAP1LC3A) increases bp(GO:autophagy) |
| pubmed:30027901 | p(HGNC:MAP1LC3A) increases a(MESH:Autophagosomes) |
| pubmed:24027553 | p(HGNC:MAP1LC3A) association path(MESH:"Plaque, Amyloid") |
| pubmed:27181519 | p(HGNC:MAP1LC3A) increases a(GO:phagophore) |
| pubmed:27181519 | act(p(HGNC:MAP1LC3A)) positiveCorrelation g(HGNC:C9orf72) |
| pubmed:30837838 | p(HGNC:MAP1LC3A, loc(GO:"inclusion body")) association path(MESH:Autophagy) |
| pubmed:30837838 | p(HGNC:MAP1LC3A, loc(GO:"inclusion body")) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:MAP1LC3A, loc(GO:"inclusion body")) association path(MESH:"Frontotemporal Lobar Degeneration") |
| pubmed:26968346 | bp(GO:"autophagosome-lysosome fusion") positiveCorrelation p(HGNC:TFEB) |
| pubmed:26968346 | bp(GO:"autophagosome-lysosome fusion") positiveCorrelation p(HGNC:PSEN1) |
| pubmed:26968346 | bp(GO:"autophagosome-lysosome fusion") positiveCorrelation p(HGNC:PSEN2) |
| pubmed:18930136 | bp(GO:"autophagosome-lysosome fusion") increases bp(GO:"protein catabolic process") |
| pubmed:18930136 | bp(GO:"autophagosome-lysosome fusion") increases bp(GO:autophagy) |
| pubmed:27181519 | bp(GO:"autophagosome-lysosome fusion") increases a(GO:autolysosome) |
| pubmed:27181519 | bp(GO:"autophagosome-lysosome fusion") increases a(GO:autolysosome) |
| pubmed:22372633 | bp(GO:"autophagosome maturation") positiveCorrelation p(HGNC:HDAC6) |
| pubmed:22372633 | bp(GO:"stress granule assembly") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:22372633 | bp(GO:"stress granule assembly") negativeCorrelation bp(GO:autophagy) |
| pubmed:22372633 | bp(GO:"stress granule assembly") increases p(HGNC:G3BP1) |
| pubmed:27181519 | bp(GO:"stress granule assembly") negativeCorrelation p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:26631930 | p(HGNC:G3BP1) increases complex(GO:"ribonucleoprotein granule") |
| pubmed:27181519 | p(HGNC:G3BP1) association complex(GO:"cytoplasmic stress granule") |
| pubmed:22372633 | composite(p(HGNC:G3BP1), p(HGNC:HDAC6)) increases bp(GO:"stress granule assembly") |
| pubmed:22372633 | p(HGNC:TARDBP) increases r(HGNC:HDAC6) |
| pubmed:30935091 | p(HGNC:TARDBP) association path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:23384725 | p(HGNC:TARDBP) association path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:30935091 | p(HGNC:TARDBP) regulates act(p(HGNC:HDAC6)) |
| pubmed:30061532 | p(HGNC:TARDBP, loc(GO:"inclusion body")) association path(MESH:"Frontotemporal Lobar Degeneration") |
| pubmed:30061532 | p(HGNC:TARDBP, loc(CONSO:"dystrophic neurite")) association path(MESH:"Frontotemporal Lobar Degeneration") |
| pubmed:21722302 | p(HGNC:TARDBP) association path(MESH:"Frontotemporal Lobar Degeneration") |
| pubmed:30837838 | act(p(HGNC:TARDBP, loc(GO:nucleus))) negativeCorrelation path(MESH:"Frontotemporal Lobar Degeneration") |
| pubmed:23516100 | act(p(HGNC:TARDBP)) negativeCorrelation p(HGNC:TARDBP, pmod(CONSO:deamidation)) |
| pubmed:30688256 | p(HGNC:TARDBP) increases path(MESH:"Oxidative Stress") |
| pubmed:30837838 | p(HGNC:TARDBP) increases path(MESH:"Oxidative Stress") |
| pubmed:30688256 | p(HGNC:TARDBP) increases path(MESH:"Mitochondrial Diseases") |
| pubmed:30688256 | p(HGNC:TARDBP) increases bp(GO:mitophagy) |
| pubmed:21722302 | p(HGNC:TARDBP) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | act(p(HGNC:TARDBP, loc(GO:nucleus))) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:29334120 | act(p(HGNC:TARDBP)) increases p(CONSO:"4R tau") |
| pubmed:18305152 | act(p(HGNC:TARDBP), ma(GO:"GU repeat RNA binding")) increases composite(p(HGNC:CFTR), p(HGNC:TARDBP)) |
| pubmed:18305152 | act(p(HGNC:TARDBP), ma(GO:"GU repeat RNA binding")) increases composite(p(HGNC:APOA2), p(HGNC:TARDBP)) |
| pubmed:18305152 | act(p(HGNC:TARDBP), ma(GO:"GU repeat RNA binding")) decreases complex(GO:"exon-exon junction complex") |
| pubmed:18305152 | act(p(HGNC:TARDBP), ma(GO:"GU repeat RNA binding")) decreases bp(GO:"RNA splicing") |
| pubmed:27181519 | p(HGNC:TARDBP) association bp(GO:"RNA splicing") |
| pubmed:18305152 | act(p(HGNC:TARDBP), ma(GO:"core promoter binding")) regulates bp(GO:"viral transcription") |
| pubmed:18305152 | p(HGNC:TARDBP) increases p(MESH:"Inclusion Bodies", pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:18305152 | p(HGNC:TARDBP) regulates bp(MESH:"Cell Proliferation") |
| pubmed:18305152 | p(HGNC:TARDBP) regulates r(HGNC:CDK6) |
| pubmed:18305152 | p(HGNC:TARDBP) regulates r(HGNC:POLD4) |
| pubmed:18305152 | p(HGNC:TARDBP) regulates r(HGNC:CCNB1) |
| pubmed:18305152 | p(HGNC:TARDBP) regulates r(HGNC:CDK2) |
| pubmed:18305152 | p(HGNC:TARDBP) regulates r(HGNC:UBE2C) |
| pubmed:18305152 | p(HGNC:TARDBP) regulates r(HGNC:SKP2) |
| pubmed:18305152 | p(HGNC:TARDBP) directlyDecreases p(HGNC:CDK6) |
| pubmed:18305152 | p(HGNC:TARDBP) directlyDecreases p(HGNC:CDK6) |
| pubmed:18305152 | p(HGNC:TARDBP) directlyDecreases p(HGNC:CDK6) |
| pubmed:18305152 | p(HGNC:TARDBP) causesNoChange p(HGNC:CDK6) |
| pubmed:18305152 | p(HGNC:TARDBP) directlyDecreases g(HGNC:CDK6) |
| pubmed:18305152 | p(HGNC:TARDBP) directlyDecreases p(HGNC:RB1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:18305152 | p(HGNC:TARDBP) causesNoChange p(HGNC:RB1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:18305152 | p(HGNC:TARDBP) directlyDecreases p(HGNC:RBL2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:18305152 | p(HGNC:TARDBP) causesNoChange p(HGNC:RBL2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:18305152 | p(HGNC:TARDBP) directlyDecreases p(HGNC:RB1) |
| pubmed:18305152 | p(HGNC:TARDBP) regulates bp(GO:"cell cycle") |
| pubmed:18305152 | p(HGNC:TARDBP) positiveCorrelation bp(GO:"G0 to G1 transition") |
| pubmed:18305152 | p(HGNC:TARDBP) negativeCorrelation bp(GO:"cell cycle G1/S phase transition") |
| pubmed:18305152 | p(HGNC:TARDBP) negativeCorrelation bp(GO:"cell cycle G2/M phase transition") |
| pubmed:18305152 | p(HGNC:TARDBP) negativeCorrelation bp(GO:"cell death") |
| pubmed:28669544 | p(HGNC:TARDBP, loc(GO:nucleus)) decreases bp(GO:"cell death") |
| pubmed:28669544 | act(p(HGNC:TARDBP)) directlyIncreases bp(GO:"cell death") |
| pubmed:28669544 | act(p(HGNC:TARDBP)) decreases bp(GO:"cell death") |
| pubmed:18305152 | p(HGNC:TARDBP) negativeCorrelation path(MESH:"Cell Nucleus Shape") |
| pubmed:18305152 | p(HGNC:TARDBP) causesNoChange path(MESH:"Cell Nucleus Shape") |
| pubmed:18305152 | p(HGNC:TARDBP) regulates p(HGNC:EMD, loc(GO:"nuclear envelope")) |
| pubmed:18305152 | p(HGNC:TARDBP) decreases bp(GO:"meiotic DNA double-strand break formation") |
| pubmed:18305152 | p(HGNC:TARDBP) decreases p(NCBIGENE:3014, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:18305152 | p(HGNC:TARDBP) decreases path(MESH:"DNA Fragmentation") |
| pubmed:18305152 | p(HGNC:TARDBP) decreases bp(GO:"nucleolar fragmentation") |
| pubmed:18305152 | p(HGNC:TARDBP) decreases p(HGNC:PARP1, frag("?")) |
| pubmed:18305152 | p(HGNC:TARDBP) decreases bp(GO:"induction of programmed cell death") |
| pubmed:18305152 | p(HGNC:TARDBP) causesNoChange bp(GO:"programmed cell death") |
| pubmed:18305152 | p(HGNC:TARDBP) negativeCorrelation bp(GO:"programmed cell death") |
| pubmed:18305152 | p(HGNC:TARDBP) negativeCorrelation bp(GO:"programmed cell death") |
| pubmed:18305152 | p(HGNC:TARDBP) negativeCorrelation path(NCIT:C17768) |
| pubmed:18305152 | p(HGNC:TARDBP) negativeCorrelation path(NCIT:C91663) |
| pubmed:23384725 | act(p(HGNC:TARDBP), ma(MESH:"Repressor Proteins")) decreases a(MESH:"DNA, Viral") |
| pubmed:23384725 | p(HGNC:TARDBP) regulates bp(GO:"mRNA transcription") |
| pubmed:23384725 | p(HGNC:TARDBP) regulates bp(GO:"RNA processing") |
| pubmed:23384725 | p(HGNC:TARDBP) association bp(GO:"synaptic signaling") |
| pubmed:23384725 | p(HGNC:TARDBP) association bp(NCIT:C19375) |
| pubmed:23384725 | p(HGNC:TARDBP) association path(OMIT:0026893) |
| pubmed:27181519 | p(HGNC:TARDBP) regulates bp(GO:autophagy) |
| pubmed:27181519 | p(HGNC:TARDBP) regulates bp(GO:"lysosome organization") |
| pubmed:27181519 | p(HGNC:TARDBP) regulates bp(GO:"autophagosome assembly") |
| pubmed:26702100 | p(HGNC:TARDBP) decreases bp(GO:"autophagosome assembly") |
| pubmed:27181519 | act(p(HGNC:TARDBP)) negativeCorrelation path(MESH:"Motor Neuron Disease") |
| pubmed:30837838 | p(HGNC:TARDBP) association path(MESH:"Motor Neuron Disease") |
| pubmed:27181519 | p(HGNC:TARDBP) regulates bp(MESH:"Transcription, Genetic") |
| pubmed:27181519 | p(HGNC:TARDBP, loc(GO:cytosol)) association complex(GO:"cytoplasmic stress granule") |
| pubmed:30837838 | p(HGNC:TARDBP) association complex(GO:"cytoplasmic stress granule") |
| pubmed:30837838 | p(HGNC:TARDBP) regulates complex(GO:"cytoplasmic stress granule") |
| pubmed:27181519 | act(p(HGNC:TARDBP)) regulates a(CHEBI:"nucleic acid") |
| pubmed:27181519 | p(HGNC:TARDBP) decreases bp(GO:"motor behavior") |
| pubmed:27181519 | p(HGNC:TARDBP) decreases bp(GO:locomotion) |
| pubmed:28669544 | p(HGNC:TARDBP) directlyIncreases deg(p(MESH:"Amyloid beta-Peptides")) |
| pubmed:28669544 | p(HGNC:TARDBP) isA p(MESH:"RNA-Binding Proteins") |
| pubmed:28669544 | p(HGNC:TARDBP) isA p(MESH:"DNA-Binding Proteins") |
| pubmed:28669544 | p(HGNC:TARDBP) isA p(MESH:"Repressor Proteins") |
| pubmed:28669544 | p(HGNC:TARDBP) increases act(p(HGNC:TARDBP), ma(GO:"mRNA binding")) |
| pubmed:30837838 | p(HGNC:TARDBP, loc(GO:cytoplasm)) decreases act(p(HGNC:TARDBP)) |
| pubmed:30837838 | p(HGNC:TARDBP, loc(GO:"inclusion body")) decreases act(p(HGNC:TARDBP), ma(MESH:"RNA Transport")) |
| pubmed:30837838 | p(HGNC:TARDBP) increases p(HGNC:TARDBP, loc(GO:"inclusion body")) |
| pubmed:26091809 | p(HGNC:TARDBP) increases p(HGNC:TARDBP, loc(GO:"glial cytoplasmic inclusion")) |
| pubmed:26091809 | p(HGNC:TARDBP) increases p(HGNC:TARDBP, loc(GO:"inclusion body")) |
| pubmed:26091809 | p(HGNC:TARDBP) increases p(HGNC:TARDBP, loc(GO:"glial cytoplasmic inclusion")) |
| pubmed:26091809 | p(HGNC:TARDBP) increases p(HGNC:TARDBP, loc(GO:"inclusion body")) |
| pubmed:26091809 | p(HGNC:TARDBP) increases p(HGNC:TARDBP, loc(GO:"inclusion body")) |
| pubmed:26091809 | p(HGNC:TARDBP) increases p(HGNC:TARDBP, loc(GO:"inclusion body")) |
| pubmed:28669544 | p(HGNC:TARDBP) isA a(MESH:"RNA Splicing Factors") |
| pubmed:28669544 | p(HGNC:TARDBP) decreases path(MESH:Phagocytosis) |
| pubmed:28669544 | p(HGNC:TARDBP) decreases path(MESH:Phagocytosis) |
| pubmed:28669544 | p(HGNC:TARDBP) decreases deg(p(HGNC:APP, loc(GO:lysosome))) |
| pubmed:28669544 | p(HGNC:TARDBP) decreases deg(p(HGNC:APP)) |
| pubmed:28669544 | p(HGNC:TARDBP) causesNoChange p(HGNC:APP) |
| pubmed:28669544 | p(HGNC:TARDBP) decreases deg(p(HGNC:APP)) |
| pubmed:30837838 | p(HGNC:TARDBP) regulates p(HGNC:APP) |
| pubmed:28669544 | p(HGNC:TARDBP) decreases p(HGNC:LAMP1) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases p(HGNC:LAMP1) |
| pubmed:28669544 | p(HGNC:TARDBP) decreases p(HGNC:LAMP2) |
| pubmed:28669544 | p(HGNC:TARDBP) decreases bp(GO:"lysosomal lumen acidification") |
| pubmed:28669544 | p(HGNC:TARDBP) decreases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) |
| pubmed:30837838 | p(HGNC:TARDBP) association p(HGNC:TFEB) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases p(HGNC:TFEB, loc(GO:nucleus)) |
| pubmed:26702100 | p(HGNC:TARDBP) increases p(HGNC:TFEB, loc(GO:cytoplasm)) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases p(HGNC:TFEB, loc(GO:nucleus)) |
| pubmed:26702100 | p(HGNC:TARDBP) increases p(HGNC:TFEB, loc(GO:cytoplasm)) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases p(HGNC:TFEB, loc(GO:lysosome)) |
| pubmed:28669544 | p(HGNC:TARDBP) decreases r(HGNC:LAMP1) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases r(HGNC:LAMP1) |
| pubmed:28669544 | p(HGNC:TARDBP) decreases r(HGNC:CTSD) |
| pubmed:28669544 | p(HGNC:TARDBP) decreases r(HGNC:CTSB) |
| pubmed:28669544 | p(HGNC:TARDBP) decreases r(HGNC:CLCN7) |
| pubmed:28669544 | p(HGNC:TARDBP) decreases r(HGNC:ATP6V1H) |
| pubmed:28669544 | p(HGNC:TARDBP) decreases r(HGNC:PSAP) |
| pubmed:28669544 | p(HGNC:TARDBP) decreases r(HGNC:PSEN2) |
| pubmed:28669544 | p(HGNC:TARDBP) increases a(MESH:Synapses) |
| pubmed:28669544 | p(HGNC:TARDBP, loc(CONSO:"amyloid-beta oligomers")) increases path(MESH:"Neuronal Plasticity") |
| pubmed:28669544 | p(HGNC:TARDBP) increases path(MESH:"Neuronal Plasticity") |
| pubmed:28669544 | p(HGNC:TARDBP) regulates act(a(MESH:Microglia)) |
| pubmed:30837838 | p(HGNC:TARDBP) association p(MESH:HIV-1) |
| pubmed:30837838 | p(HGNC:TARDBP) regulates path(MESH:"Gene Expression Regulation, Viral") |
| pubmed:30837838 | act(p(HGNC:TARDBP), ma(MESH:"RNA Splicing")) association p(HGNC:CFTR) |
| pubmed:30837838 | p(HGNC:TARDBP) regulates p(HGNC:CFTR) |
| pubmed:30837838 | p(HGNC:TARDBP) association path(MESH:"Embryonic Development") |
| pubmed:30837838 | p(HGNC:TARDBP) association bp(GO:"neuron development") |
| pubmed:30837838 | p(HGNC:TARDBP) association path(MESH:"Muscular Atrophy, Spinal") |
| pubmed:30837838 | p(HGNC:TARDBP, loc(MESH:Cytoplasm)) increases a(MESH:"Inclusion Bodies") |
| pubmed:30837838 | p(HGNC:TARDBP) association path(MESH:"RNA Stability") |
| pubmed:30837838 | p(HGNC:TARDBP) association path(MESH:"Transcription, Genetic") |
| pubmed:30837838 | p(HGNC:TARDBP) association path(MESH:"Protein Biosynthesis") |
| pubmed:30837838 | p(HGNC:TARDBP) decreases path(MESH:"Protein Biosynthesis") |
| pubmed:30837838 | p(HGNC:TARDBP) association bp(GO:"primary miRNA processing") |
| pubmed:30837838 | p(HGNC:TARDBP) association p(MESH:"RNA, Long Noncoding") |
| pubmed:30837838 | p(HGNC:TARDBP) association path(MESH:"RNA Transport") |
| pubmed:30837838 | p(HGNC:TARDBP) association path(MESH:"Active Transport, Cell Nucleus") |
| pubmed:30837838 | p(HGNC:TARDBP) regulates p(HGNC:FUS) |
| pubmed:30837838 | p(HGNC:TARDBP) regulates p(HGNC:SNCA) |
| pubmed:30837838 | p(HGNC:TARDBP) regulates p(HGNC:HTT) |
| pubmed:30837838 | p(HGNC:TARDBP) regulates path(MESH:"RNA Splicing") |
| pubmed:30837838 | p(HGNC:TARDBP) negativeCorrelation p(MESH:Neurons) |
| pubmed:30837838 | p(HGNC:TARDBP) regulates p(NCBIGENE:5740544) |
| pubmed:30837838 | p(HGNC:TARDBP) regulates p(HGNC:G3BP1) |
| pubmed:30837838 | p(HGNC:TARDBP) regulates p(HGNC:TIA1) |
| pubmed:30837838 | p(HGNC:TARDBP) increases p(MESH:MicroRNAs) |
| pubmed:30837838 | p(HGNC:TARDBP) increases r(HGNC:NEAT1) |
| pubmed:30837838 | p(HGNC:TARDBP) increases r(HGNC:MALAT1) |
| pubmed:30837838 | p(HGNC:TARDBP, loc(GO:cytoplasm)) increases a(MESH:"Toxic Actions") |
| pubmed:30837838 | p(HGNC:TARDBP) regulates path(MESH:"Chromatin Assembly and Disassembly") |
| pubmed:30837838 | act(p(HGNC:TARDBP), ma(GO:"regulation of RNA binding")) negativeCorrelation p(HGNC:TARDBP, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30837838 | deg(p(HGNC:TARDBP)) association bp(GO:"vacuole fusion") |
| pubmed:30837838 | deg(p(HGNC:TARDBP)) association path(MESH:"Endoplasmic Reticulum-Associated Degradation") |
| pubmed:30837838 | deg(p(HGNC:TARDBP)) association path(MESH:Autophagy) |
| pubmed:30837838 | p(HGNC:TARDBP) increases a(MESH:Endosomes) |
| pubmed:30837838 | p(HGNC:TARDBP) increases path(MESH:Growth) |
| pubmed:30837838 | p(HGNC:TARDBP) increases path(MESH:Survival) |
| pubmed:30837838 | p(HGNC:TARDBP) decreases path(MESH:"Mitochondrial Size") |
| pubmed:30837838 | p(HGNC:TARDBP) decreases path(MESH:Movement) |
| pubmed:30837838 | p(HGNC:TARDBP) increases bp(GO:"mitochondrial fission") |
| pubmed:30837838 | p(HGNC:TARDBP) increases bp(GO:"mitochondrial fragmentation involved in apoptotic process") |
| pubmed:30837838 | p(HGNC:TARDBP) decreases path(MESH:"Mitochondrial Dynamics") |
| pubmed:30837838 | p(HGNC:TARDBP) increases path(MESH:"Protein Carbonylation") |
| pubmed:30837838 | p(HGNC:TARDBP) increases p(NCBIGENE:41503) |
| pubmed:30837838 | p(HGNC:TARDBP, loc(GO:cytoplasm)) negativeCorrelation p(HGNC:SOD1, pmod(MESH:"Protein Aggregates"), var("?")) |
| pubmed:30837838 | p(HGNC:TARDBP) increases p(HGNC:DNM1L) |
| pubmed:30837838 | p(HGNC:TARDBP) increases p(HGNC:FIS1) |
| pubmed:30837838 | p(HGNC:TARDBP) increases tloc(p(HGNC:CHCHD10), fromLoc(GO:mitochondrion), toLoc(GO:nucleus)) |
| pubmed:30837838 | p(HGNC:TARDBP) decreases p(MESH:"Heat-Shock Proteins") |
| pubmed:30837838 | p(HGNC:TARDBP) decreases p(MESH:Histones) |
| pubmed:30837838 | p(HGNC:TARDBP, loc(GO:nucleus)) regulates r(HGNC:SS18) |
| pubmed:30837838 | p(HGNC:TARDBP) increases p(CONSO:"Histone H3", pmod(mod:00430 ! "trimethylated residue", Lys, 9)) |
| pubmed:30837838 | act(p(HGNC:TARDBP), ma(GO:"nucleic acid binding")) negativeCorrelation a(PUBCHEM:68476) |
| pubmed:26091809 | p(HGNC:TARDBP) positiveCorrelation path(MESH:Aging) |
| pubmed:26091809 | p(HGNC:TARDBP) increases path(MESH:"Intranuclear Inclusion Bodies") |
| pubmed:26091809 | p(HGNC:TARDBP) increases path(MESH:Mortality) |
| pubmed:26702100 | p(HGNC:TARDBP) increases p(HGNC:MTOR) |
| pubmed:26702100 | p(HGNC:TARDBP) increases p(HGNC:MTOR) |
| pubmed:26702100 | p(HGNC:TARDBP) regulates p(HGNC:MTOR) |
| pubmed:26702100 | p(HGNC:TARDBP) increases act(p(HGNCGENEFAMILY:"MTOR complex 1")) |
| pubmed:26702100 | act(p(HGNC:TARDBP)) association p(HGNCGENEFAMILY:"MTOR complex 1") |
| pubmed:26702100 | p(HGNC:TARDBP) increases p(HGNC:RPTOR) |
| pubmed:26702100 | p(HGNC:TARDBP) causesNoChange p(HGNC:RPTOR) |
| pubmed:26702100 | p(HGNC:TARDBP) association p(HGNC:RPTOR) |
| pubmed:26702100 | p(HGNC:TARDBP) increases p(HGNC:RPTOR) |
| pubmed:26702100 | p(HGNC:TARDBP) regulates p(HGNC:RPTOR) |
| pubmed:26702100 | p(HGNC:TARDBP) causesNoChange p(HGNC:LAMTOR1) |
| pubmed:26702100 | p(HGNC:TARDBP) causesNoChange p(HGNC:RRAGB) |
| pubmed:26702100 | p(HGNC:TARDBP) increases r(HGNC:RPTOR) |
| pubmed:26702100 | p(HGNC:TARDBP) increases r(HGNC:RPTOR) |
| pubmed:26702100 | p(HGNC:TARDBP) increases act(r(HGNC:RPTOR)) |
| pubmed:26702100 | p(HGNC:TARDBP) causesNoChange r(HGNC:MTOR) |
| pubmed:26702100 | p(HGNC:TARDBP) causesNoChange r(HGNC:RRAGB) |
| pubmed:26702100 | p(HGNC:TARDBP) causesNoChange r(HGNC:LAMTOR1) |
| pubmed:26702100 | p(HGNC:TARDBP) causesNoChange r(HGNC:LAMTOR3) |
| pubmed:26702100 | p(HGNC:TARDBP) causesNoChange r(HGNC:LAMTOR2) |
| pubmed:26702100 | p(HGNC:TARDBP) causesNoChange r(HGNC:LAMTOR5) |
| pubmed:26702100 | p(HGNC:TARDBP) causesNoChange r(HGNC:LAMTOR4) |
| pubmed:26702100 | p(HGNC:TARDBP) causesNoChange r(HGNC:RRAGA) |
| pubmed:26702100 | p(HGNC:TARDBP) causesNoChange r(HGNC:RRAGC) |
| pubmed:26702100 | p(HGNC:TARDBP) causesNoChange r(HGNC:RRAGD) |
| pubmed:26702100 | p(HGNC:TARDBP) causesNoChange r(HGNC:FLCN) |
| pubmed:26702100 | p(HGNC:TARDBP) causesNoChange p(HGNC:RRAGA, loc(GO:lysosome)) |
| pubmed:26702100 | p(HGNC:TARDBP) causesNoChange p(HGNC:RRAGC, loc(GO:lysosome)) |
| pubmed:26702100 | p(HGNC:TARDBP) causesNoChange p(HGNC:TFEB, var("p.Met1_Val30del"), loc(GO:lysosome)) |
| pubmed:26702100 | p(HGNC:TARDBP) causesNoChange p(HGNC:TFEB, var("p.Gln10Ala"), var("p.Lys11Ala"), loc(GO:lysosome)) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases a(GO:lysosome) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases p(HGNCGENEFAMILY:Cathepsins) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases r(HGNCGENEFAMILY:Cathepsins) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases a(MESH:"Vacuolar Proton-Translocating ATPases") |
| pubmed:26702100 | p(HGNC:TARDBP) decreases p(HGNC:ATG5) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases r(HGNC:ATG5) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases p(HGNC:BECN1) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases r(HGNC:BECN1) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases p(HGNC:ATG9B) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases r(HGNC:ATG9B) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases a(GO:autophagosome) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases a(GO:autophagosome) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases p(HGNC:SQSTM1) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases p(HGNC:SQSTM1) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases p(HGNC:MAP1LC3A) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases p(HGNC:MAP1LC3B) |
| pubmed:26702100 | p(HGNC:TARDBP) regulates a(GO:autolysosome) |
| pubmed:26702100 | p(HGNC:TARDBP) increases bp(GO:"autophagosome-lysosome fusion") |
| pubmed:26702100 | p(HGNC:TARDBP) increases bp(GO:"autophagosome-lysosome fusion") |
| pubmed:26702100 | p(HGNC:TARDBP) decreases r(HGNC:SQSTM1) |
| pubmed:26702100 | p(HGNC:TARDBP) increases g(HGNC:DCTN1) |
| pubmed:26702100 | p(HGNC:TARDBP) increases p(HGNC:DCTN1) |
| pubmed:26702100 | p(HGNC:TARDBP) causesNoChange a(MESH:Dyneins) |
| pubmed:26702100 | p(HGNC:TARDBP) increases p(HGNC:EIF4EBP1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26702100 | p(HGNC:TARDBP) increases p(HGNC:RPS6KB1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26702100 | p(HGNC:TARDBP) causesNoChange r(HGNC:RPS6KB1) |
| pubmed:26702100 | p(HGNC:TARDBP) increases g(HGNC:RPTOR) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases g(HGNC:ATP6V1H) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases g(HGNC:CTSB) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases g(HGNC:CTSD) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases g(HGNC:LAMP1) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases g(HGNC:PSAP) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases g(HGNC:SGSH) |
| pubmed:26702100 | p(HGNC:TARDBP) decreases g(HGNC:BECN1) |
| pubmed:22372633 | p(HGNC:FUS) increases r(HGNC:HDAC6) |
| pubmed:30935091 | p(HGNC:FUS) association path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:30935091 | p(HGNC:FUS) regulates act(p(HGNC:HDAC6)) |
| pubmed:26631930 | p(HGNC:FUS) decreases p(CONSO:"4R tau") |
| pubmed:26631930 | p(HGNC:FUS) decreases p(CONSO:"Tau isoform F (441 aa)") |
| pubmed:26631930 | p(HGNC:FUS) decreases p(CONSO:"Tau isoform C (410 aa)") |
| pubmed:26631930 | p(HGNC:FUS) association path(MESH:"Frontotemporal Lobar Degeneration") |
| pubmed:27181519 | p(HGNC:FUS) regulates bp(MESH:"Transcription, Genetic") |
| pubmed:27181519 | p(HGNC:FUS) association bp(GO:"RNA splicing") |
| pubmed:27181519 | p(HGNC:FUS) association bp(GO:"DNA repair") |
| pubmed:27181519 | p(HGNC:FUS, loc(GO:cytosol)) association complex(GO:"cytoplasmic stress granule") |
| pubmed:27181519 | p(HGNC:FUS) association path(DOID:"motor neuron disease") |
| pubmed:27181519 | act(p(HGNC:FUS)) regulates a(CHEBI:"nucleic acid") |
| pubmed:30837838 | p(HGNC:FUS) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:29758300 | path(MESH:"Bulbo-Spinal Atrophy, X-Linked") negativeCorrelation bp(GO:macroautophagy) |
| pubmed:14556719 | path(MESH:"Bulbo-Spinal Atrophy, X-Linked") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) |
| pubmed:14556719 | path(MESH:"Bulbo-Spinal Atrophy, X-Linked") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) |
| pubmed:18930136 | path(MESH:"Bulbo-Spinal Atrophy, X-Linked") negativeCorrelation bp(GO:autophagy) |
| pubmed:22372633 | complex(GO:"proteasome complex") decreases composite(p(HGNC:HDAC6), p(HGNC:MAPT)) |
| pubmed:30935091 | complex(GO:"proteasome complex") decreases p(HGNC:MAPT, pmod(CONSO:"protein aggregates"), pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30935091 | complex(GO:"proteasome complex") decreases p(HGNC:HDAC6, pmod(CONSO:"protein aggregates")) |
| pubmed:22040696 | complex(GO:"proteasome complex") regulates p(FPLX:CHRN) |
| pubmed:22040696 | complex(GO:"proteasome complex") increases bp(GO:"modulation of chemical synaptic transmission") |
| pubmed:22040696 | complex(GO:"proteasome complex") regulates p(HGNC:RIC3) |
| pubmed:29758300 | complex(GO:"proteasome complex") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29758300 | complex(GO:"proteasome complex") association p(HGNC:MAPT, frag("?")) |
| pubmed:29758300 | complex(GO:"proteasome complex") increases deg(p(HGNC:SNCA)) |
| pubmed:14556719 | complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(GO:"protein K48-linked ubiquitination"))) |
| pubmed:14556719 | complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(GO:"protein K63-linked ubiquitination"))) |
| pubmed:14556719 | complex(GO:"proteasome complex") increases deg(complex(p(HGNC:OAZ1), p(HGNC:ODC1))) |
| pubmed:14556719 | complex(GO:"proteasome complex") increases a(CHEBI:peptide) |
| pubmed:14556719 | complex(GO:"proteasome complex") regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:14556719 | complex(GO:"proteasome complex") increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:22908190 | act(complex(GO:"proteasome complex")) negativeCorrelation a(CHEBI:amyloid-beta) |
| pubmed:14556719 | act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:aging) |
| pubmed:22908190 | act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:aging) |
| pubmed:22908190 | act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:aging) |
| pubmed:14556719 | act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:SOD1, var("?")) |
| pubmed:14556719 | act(complex(GO:"proteasome complex")) decreases bp(GO:autophagy) |
| pubmed:18930136 | act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:autophagy) |
| pubmed:14556719 | act(complex(GO:"proteasome complex")) decreases p(HGNC:HTT, frag("?")) |
| pubmed:22908190 | complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"))) |
| pubmed:22908190 | complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(go:0070936 ! "protein K48-linked ubiquitination"))) |
| pubmed:22908190 | act(complex(GO:"proteasome complex")) negativeCorrelation a(CONSO:"paired helical filaments") |
| pubmed:22908190 | act(complex(GO:"proteasome complex")) negativeCorrelation a(GO:"neurofibrillary tangle") |
| pubmed:22908190 | act(complex(GO:"proteasome complex")) negativeCorrelation complex(a(GO:"proteasome regulatory particle"), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) |
| pubmed:22908190 | complex(GO:"proteasome complex") increases deg(p(FPLX:PKA, pmod(go:0016567 ! "protein ubiquitination"))) |
| pubmed:22908190 | complex(GO:"proteasome complex") increases deg(p(HGNC:MAPT)) |
| pubmed:22908190 | complex(GO:"proteasome complex") increases deg(p(HGNC:MAPT)) |
| pubmed:22908190 | act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:MAPT) |
| pubmed:26751493 | act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:MAPT) |
| pubmed:17954934 | act(complex(GO:"proteasome complex")) increases deg(p(HGNC:MAPT)) |
| pubmed:24457024 | complex(GO:"proteasome complex") regulates complex(a(MESH:Proteins), a(MESH:Ubiquitin)) |
| pubmed:18930136 | act(complex(GO:"proteasome complex")) decreases path(CONSO:Neurodegeneration) |
| pubmed:18930136 | act(complex(GO:"proteasome complex")) decreases p(HGNC:SQSTM1) |
| pubmed:18930136 | act(complex(GO:"proteasome complex")) decreases r(HGNC:SQSTM1) |
| pubmed:30116051 | complex(GO:"proteasome complex") increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) |
| pubmed:30116051 | complex(GO:"proteasome complex") increases deg(a(CONSO:"Tau oligomers")) |
| pubmed:17954934 | act(complex(GO:"proteasome complex")) isA complex(GO:"proteasome complex") |
| pubmed:17954934 | act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:BAG1) |
| pubmed:26041011 | act(complex(GO:"proteasome complex")) decreases a(CONSO:"Tau aggregates") |
| pubmed:27181519 | act(complex(GO:"proteasome complex")) negativeCorrelation complex(GO:"cytoplasmic stress granule") |
| pubmed:27181519 | complex(GO:"proteasome complex") decreases complex(GO:"cytoplasmic stress granule") |
| pubmed:27181519 | complex(GO:"proteasome complex") increases deg(p(HGNC:TARDBP)) |
| pubmed:22372633 | composite(p(HGNC:HDAC6), p(HGNC:MAPT)) increases p(CONSO:"Tau aggregates") |
| pubmed:22372633 | p(HGNC:PRKN) positiveCorrelation bp(GO:mitophagy) |
| pubmed:30515821 | act(p(HGNC:PRKN)) increases bp(GO:mitophagy) |
| pubmed:30688256 | act(p(HGNC:PRKN)) increases bp(GO:mitophagy) |
| pubmed:30688256 | p(HGNC:PRKN) increases bp(GO:mitophagy) |
| pubmed:21722302 | p(HGNC:PRKN) association bp(GO:mitophagy) |
| pubmed:21722302 | p(HGNC:PRKN) increases bp(GO:mitophagy) |
| pubmed:26968346 | p(HGNC:PRKN) association bp(GO:mitophagy) |
| pubmed:22908190 | p(HGNC:PRKN) increases bp(GO:mitophagy) |
| pubmed:30515821 | p(HGNC:PRKN) negativeCorrelation path(DOID:"Parkinson's disease") |
| pubmed:30515821 | p(HGNC:PRKN) increases path(MESH:Neuroprotection) |
| pubmed:30515821 | p(HGNC:PRKN) decreases bp(GO:"programmed cell death") |
| pubmed:30515821 | p(HGNC:PRKN) positiveCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30688256 | p(HGNC:PRKN) association path(MESH:"Parkinson Disease") |
| pubmed:21722302 | p(HGNC:PRKN) association path(MESH:"Parkinson Disease") |
| pubmed:14556719 | p(HGNC:PRKN) positiveCorrelation path(MESH:"Parkinson Disease") |
| pubmed:22908190 | p(HGNC:PRKN) positiveCorrelation path(MESH:"Parkinson Disease") |
| pubmed:27181519 | p(HGNC:PRKN) association path(MESH:"Parkinson Disease") |
| pubmed:30688256 | act(p(HGNC:PRKN)) increases deg(a(MESH:Mitochondria)) |
| pubmed:30688256 | p(HGNC:PRKN) increases act(a(MESH:Mitochondria)) |
| pubmed:30688256 | p(HGNC:PRKN, loc(MESH:Mitochondria)) decreases act(p(HGNC:PINK1)) |
| pubmed:30688256 | p(HGNC:PRKN) increases p(HGNC:MFN1, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:30688256 | p(HGNC:PRKN) increases p(HGNC:MFN2, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:30688256 | p(HGNC:PRKN) decreases bp(GO:"mitochondrial fusion") |
| pubmed:30688256 | p(HGNC:PRKN) increases deg(p(HGNC:MFN1)) |
| pubmed:30688256 | p(HGNC:PRKN) increases deg(p(HGNC:MFN2)) |
| pubmed:30688256 | p(HGNC:PRKN) decreases bp(GO:"apoptotic process") |
| pubmed:30688256 | p(HGNC:PRKN) decreases path(MESH:"Oxidative Stress") |
| pubmed:30688256 | act(p(HGNC:PRKN)) increases deg(p(HGNC:RHOT1)) |
| pubmed:21722302 | p(HGNC:PRKN) increases bp(GO:"proteasomal protein catabolic process") |
| pubmed:22908190 | p(HGNC:PRKN) increases bp(GO:"proteasomal protein catabolic process") |
| pubmed:21722302 | p(HGNC:PRKN) increases bp(MESH:"Cell Survival") |
| pubmed:21722302 | p(HGNC:PRKN) negativeCorrelation bp(GO:"JNK cascade") |
| pubmed:21722302 | p(HGNC:PRKN) increases p(HGNCGENEFAMILY:"Voltage dependent anion channels", pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:21722302 | p(HGNC:PRKN) regulates bp(MESH:"Protein Stability") |
| pubmed:26968346 | p(HGNC:PRKN) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:26968346 | p(HGNC:PRKN) increases act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:27299292 | p(HGNC:PRKN) association composite(p(HGNC:MITF), p(HGNC:TFE3), p(HGNC:TFEB)) |
| pubmed:14556719 | p(HGNC:PRKN) association p(HGNC:PSMD4) |
| pubmed:14556719 | p(HGNC:PRKN) association bp(MESH:"Synaptic Transmission") |
| pubmed:14556719 | p(HGNC:PRKN) negativeCorrelation a(MESH:"Dopaminergic Neurons") |
| pubmed:14556719 | p(HGNC:PRKN) increases p(HGNC:SEPT5, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:14556719 | p(HGNC:PRKN) association p(HGNC:GPR37) |
| pubmed:14556719 | p(HGNC:PRKN) decreases bp(GO:"response to unfolded protein") |
| pubmed:14556719 | p(HGNC:PRKN) decreases act(p(HGNC:SNCA)) |
| pubmed:14556719 | p(HGNC:PRKN) regulates p(HGNC:SNCA) |
| pubmed:14556719 | p(HGNC:PRKN) association p(HGNC:SNCA, pmod(go:0006493 ! "protein O-linked glycosylation")) |
| pubmed:14556719 | p(HGNC:PRKN) increases p(HGNC:SNCAIP, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:14556719 | p(HGNC:PRKN) increases p(HGNC:SNCAIP, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:14556719 | p(HGNC:PRKN) increases tloc(p(HGNC:SNCAIP, pmod(go:0016567 ! "protein ubiquitination")), fromLoc(GO:cytosol), toLoc(MESH:"Inclusion Bodies")) |
| pubmed:14556719 | p(HGNC:PRKN) increases act(complex(GO:"proteasome complex")) |
| pubmed:14556719 | p(HGNC:PRKN) decreases act(p(HGNC:CASP12)) |
| pubmed:14556719 | p(HGNC:PRKN) association p(HGNC:CCNE1) |
| pubmed:14556719 | p(HGNC:PRKN) decreases p(HGNC:CCNE1) |
| pubmed:14556719 | p(HGNC:PRKN) decreases bp(GO:"neuron apoptotic process") |
| pubmed:14556719 | p(HGNC:PRKN) decreases bp(GO:"cell death") |
| pubmed:14556719 | p(HGNC:PRKN) increases p(HGNC:SYT11, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:14556719 | p(HGNC:PRKN) association a(GO:"actin filament") |
| pubmed:14556719 | p(HGNC:PRKN) regulates act(a(MESH:Actins)) |
| pubmed:14556719 | p(HGNC:PRKN) association p(HGNC:SNCA, pmod(go:0006486 ! "protein glycosylation")) |
| pubmed:23528736 | p(HGNC:PRKN) association path(MESH:"Neurodegenerative Diseases") |
| pubmed:23528736 | p(HGNC:PRKN) association path(MESH:"Alzheimer Disease") |
| pubmed:27181519 | p(HGNC:PRKN) increases complex(a(GO:mitochondrion), p(HGNC:OPTN)) |
| pubmed:30837838 | p(HGNC:PRKN) increases p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination", Lys, 48)) |
| pubmed:30837838 | p(HGNC:PRKN) increases p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination", Lys, 63)) |
| pubmed:22372633 | bp(GO:mitophagy) positiveCorrelation p(HGNC:PRKN) |
| pubmed:21722302 | bp(GO:mitophagy) association p(HGNC:PRKN) |
| pubmed:26968346 | bp(GO:mitophagy) association p(HGNC:PRKN) |
| pubmed:30515821 | bp(GO:mitophagy) regulates path(MESH:"Mitochondrial Dynamics") |
| pubmed:30688256 | bp(GO:mitophagy) isA bp(GO:autophagy) |
| pubmed:30688256 | bp(GO:mitophagy) increases deg(a(MESH:Mitochondria)) |
| pubmed:30688256 | bp(GO:mitophagy) decreases path(HBP:"mitochondrial dysfunction") |
| pubmed:30688256 | bp(GO:mitophagy) decreases p(HGNC:PRKN, var("?")) |
| pubmed:30688256 | bp(GO:mitophagy) association a(CHEBI:"reactive oxygen species") |
| pubmed:30688256 | bp(GO:mitophagy) association bp(GO:"lipid oxidation") |
| pubmed:30688256 | bp(GO:mitophagy) association p(HGNC:HTT) |
| pubmed:30688256 | bp(GO:mitophagy) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30688256 | bp(GO:mitophagy) decreases bp(GO:"cell death") |
| pubmed:30688256 | bp(GO:mitophagy) association p(HGNC:SOD1, var("?")) |
| pubmed:21722302 | bp(GO:mitophagy) increases path(MESH:"Parkinson Disease") |
| pubmed:26968346 | bp(GO:mitophagy) association p(HGNC:PINK1) |
| pubmed:26968346 | bp(GO:mitophagy) association p(HGNC:TFEB) |
| pubmed:27299292 | bp(GO:mitophagy) positiveCorrelation composite(p(HGNC:ATG5), p(HGNC:ATG9A), p(HGNC:MITF), p(HGNC:PINK1), p(HGNC:PRKN), p(HGNC:TFE3), p(HGNC:TFEB)) |
| pubmed:18930136 | bp(GO:mitophagy) isA bp(GO:macroautophagy) |
| pubmed:30116051 | bp(GO:mitophagy) negativeCorrelation g(HGNC:PSEN1, var("?")) |
| pubmed:22372633 | complex(a(MESH:Mitochondria), p(HGNC:HDAC6), p(HGNC:SQSTM1)) increases deg(a(MESH:Mitochondria)) |
| pubmed:22372633 | path(DOID:"retinal degeneration") negativeCorrelation p(HGNC:HDAC6) |
| pubmed:22372633 | path(DOID:"retinal degeneration") positiveCorrelation p(HGNC:SNCA, var("?")) |
| pubmed:22372633 | bp(MESH:Locomotion) positiveCorrelation p(HGNC:HDAC6) |
| pubmed:23516100 | path(DOID:"Huntington's disease") increases tloc(p(HGNC:HTT, frag("?")), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:23516100 | path(DOID:"Huntington's disease") positiveCorrelation p(HGNC:HTT, frag("?")) |
| pubmed:23516100 | path(DOID:"Huntington's disease") negativeCorrelation bp(GO:"calcium ion homeostasis") |
| pubmed:20556492 | path(DOID:"Huntington's disease") decreases bp(GO:"calcium ion homeostasis") |
| pubmed:23516100 | path(DOID:"Huntington's disease") decreases act(p(HGNCGENEFAMILY:Calpains)) |
| pubmed:23516100 | path(DOID:"Huntington's disease") increases p(HGNC:CAPN1) |
| pubmed:23516100 | path(DOID:"Huntington's disease") increases p(HGNC:CAPN5) |
| pubmed:23516100 | path(DOID:"Huntington's disease") increases p(HGNC:CAPN7) |
| pubmed:23516100 | path(DOID:"Huntington's disease") increases p(HGNC:CAPN10) |
| pubmed:23516100 | path(DOID:"Huntington's disease") increases act(p(HGNC:CASP6)) |
| pubmed:23516100 | path(DOID:"Huntington's disease") causesNoChange act(p(HGNC:CASP3)) |
| pubmed:20556492 | path(DOID:"Huntington's disease") decreases bp(GO:"glucose import") |
| pubmed:20556492 | path(DOID:"Huntington's disease") increases a(CHEBI:lactate) |
| pubmed:20556492 | path(DOID:"Huntington's disease") negativeCorrelation bp(GO:"regulation of succinate dehydrogenase activity") |
| pubmed:20556492 | path(DOID:"Huntington's disease") negativeCorrelation bp(GO:"tricarboxylic acid cycle") |
| pubmed:20556492 | path(DOID:"Huntington's disease") decreases p(HGNCGENEFAMILY:"Mitochondrial complex II: succinate dehydrogenase subunits") |
| pubmed:20556492 | path(DOID:"Huntington's disease") decreases act(p(HGNCGENEFAMILY:"Mitochondrial complex III: ubiquinol-cytochrome c reductase complex subunits")) |
| pubmed:20556492 | path(DOID:"Huntington's disease") decreases act(p(HGNCGENEFAMILY:"Mitochondrial complex IV: cytochrome c oxidase subunits")) |
| pubmed:20556492 | path(DOID:"Huntington's disease") decreases a(EFO:"mitochondrial DNA") |
| pubmed:20556492 | path(DOID:"Huntington's disease") decreases bp(GO:"ATP biosynthetic process") |
| pubmed:20556492 | path(DOID:"Huntington's disease") decreases bp(GO:"ATP biosynthetic process") |
| pubmed:20556492 | path(DOID:"Huntington's disease") increases bp(GO:"negative regulation of mitochondrial membrane potential") |
| pubmed:20556492 | path(DOID:"Huntington's disease") negativeCorrelation bp(MESH:"Energy Metabolism") |
| pubmed:20556492 | path(DOID:"Huntington's disease") increases path(DOID:"muscular atrophy") |
| pubmed:20556492 | path(DOID:"Huntington's disease") decreases bp(GO:"membrane depolarization") |
| pubmed:23393546 | path(DOID:"Huntington's disease") negativeCorrelation bp(GO:"MAPK cascade") |
| pubmed:23393546 | path(DOID:"Huntington's disease") negativeCorrelation bp(GO:"MAPK cascade") |
| pubmed:23393546 | path(DOID:"Huntington's disease") decreases bp(GO:"motor behavior") |
| pubmed:23393546 | path(DOID:"Huntington's disease") decreases p(HGNC:PPP1R1B) |
| pubmed:23393546 | path(DOID:"Huntington's disease") association p(HGNC:DRD2) |
| pubmed:23393546 | path(DOID:"Huntington's disease") association p(HGNC:DRD2) |
| pubmed:23393546 | path(DOID:"Huntington's disease") association p(HGNC:GAD2) |
| pubmed:23393546 | path(DOID:"Huntington's disease") association p(HGNC:GAD2) |
| pubmed:23393546 | path(DOID:"Huntington's disease") association p(HGNC:GAD1) |
| pubmed:23393546 | path(DOID:"Huntington's disease") association p(HGNC:GAD1) |
| pubmed:23393546 | path(DOID:"Huntington's disease") association p(HGNC:GRIA2) |
| pubmed:23393546 | path(DOID:"Huntington's disease") association p(HGNC:GRIA3) |
| pubmed:23393546 | path(DOID:"Huntington's disease") association p(HGNC:HTR1B) |
| pubmed:23393546 | path(DOID:"Huntington's disease") association p(HGNC:HTR1B) |
| pubmed:23393546 | path(DOID:"Huntington's disease") decreases p(HGNC:GRM2) |
| pubmed:23393546 | path(DOID:"Huntington's disease") decreases p(HGNC:GRM3) |
| pubmed:23393546 | path(DOID:"Huntington's disease") increases bp(GO:"negative regulation of cell volume") |
| pubmed:26968346 | path(DOID:"Huntington's disease") decreases r(HGNC:TFEB) |
| pubmed:26968346 | path(DOID:"Huntington's disease") decreases bp(GO:autophagy) |
| pubmed:26968346 | path(DOID:"Huntington's disease") decreases bp(GO:"lysosomal protein catabolic process") |
| pubmed:27299292 | path(DOID:"Huntington's disease") increases p(HGNC:TFEB) |
| pubmed:27299292 | path(DOID:"Huntington's disease") positiveCorrelation p(CONSO:"huntingtin aggregates") |
| pubmed:23384725 | path(DOID:"Huntington's disease") association composite(a(MESH:"Inclusion Bodies"), p(HGNC:TARDBP)) |
| pubmed:22372633 | p(HGNC:TARDBP, var("?")) increases complex(p(HGNC:TARDBP), r(HGNC:HDAC6), loc(GO:"cytoplasmic stress granule")) |
| pubmed:30688256 | p(HGNC:TARDBP, var("?")) increases a(CHEBI:"reactive oxygen species") |
| pubmed:30688256 | p(HGNC:TARDBP, var("?")) increases path(MESH:"Mitochondrial Diseases") |
| pubmed:30688256 | p(HGNC:TARDBP, var("?")) increases p(HGNC:NFE2L2) |
| pubmed:30837838 | p(HGNC:TARDBP, var("?")) increases p(HGNC:NFE2L2, loc(GO:nucleus)) |
| pubmed:21722302 | p(HGNC:TARDBP, var("?")) biomarkerFor path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:29980653 | p(HGNC:TARDBP, var("?")) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:TARDBP, var("?")) increases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:21722302 | p(HGNC:TARDBP, var("?")) biomarkerFor path(MESH:"Frontotemporal Lobar Degeneration") |
| pubmed:30837838 | p(HGNC:TARDBP, var("?")) increases path(MESH:"Frontotemporal Lobar Degeneration") |
| pubmed:29980653 | p(HGNC:TARDBP, var("?")) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pubmed:27181519 | p(HGNC:TARDBP, var("?")) increases path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:27181519 | p(HGNC:TARDBP, var("?")) positiveCorrelation path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:27181519 | p(HGNC:TARDBP, var("?")) negativeCorrelation bp(GO:autophagy) |
| pubmed:30837838 | p(HGNC:TARDBP, var("?")) decreases path(MESH:"RNA Transport") |
| pubmed:30837838 | p(HGNC:TARDBP, var("?")) increases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30837838 | p(HGNC:TARDBP, var("?")) negativeCorrelation bp(GO:"regulation of cytoplasmic transport") |
| pubmed:30837838 | p(HGNC:TARDBP, var("?")) decreases path(MESH:"Protein Stability") |
| pubmed:30837838 | p(HGNC:TARDBP, var("?")) decreases path(MESH:Proteolysis) |
| pubmed:30837838 | p(HGNC:TARDBP, var("?")) decreases path(MESH:"Protein Binding") |
| pubmed:30837838 | p(HGNC:TARDBP, var("?")) decreases complex(p(HGNC:ATG7), p(HGNC:TARDBP)) |
| pubmed:30837838 | p(HGNC:TARDBP, var("?")) decreases path(MESH:"Mitochondrial Size") |
| pubmed:30837838 | p(HGNC:TARDBP, var("?")) decreases path(MESH:Movement) |
| pubmed:30837838 | p(HGNC:TARDBP, var("?")) decreases bp(GO:"mitochondrial transport") |
| pubmed:30837838 | p(HGNC:TARDBP, var("?")) decreases bp(GO:"mitochondrion distribution") |
| pubmed:30837838 | p(HGNC:TARDBP, var("?")) increases path(MESH:"Oxidative Stress") |
| pubmed:30837838 | p(HGNC:TARDBP, var("?")) decreases complex(p(HGNC:RMDN3), p(HGNC:VAPB)) |
| pubmed:30837838 | p(HGNC:TARDBP, var("?")) decreases bp(GO:"positive regulation of mitochondrial calcium ion concentration") |
| pubmed:30837838 | p(HGNC:TARDBP, var("?")) negativeCorrelation bp(GO:"axonal transport of mitochondrion") |
| pubmed:30837838 | p(HGNC:TARDBP, var("?")) decreases p(HGNC:SS18) |
| pubmed:22372633 | p(HGNC:FUS, var("?")) increases complex(p(HGNC:FUS), r(HGNC:HDAC6), loc(GO:"cytoplasmic stress granule")) |
| pubmed:30935091 | p(HGNC:FUS, var("?")) increases p(HGNC:FUS, loc(GO:cytoplasm)) |
| pubmed:30935091 | p(HGNC:FUS, var("?")) negativeCorrelation bp(GO:"axonal transport") |
| pubmed:27181519 | p(HGNC:FUS, var("?")) increases path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:27181519 | p(HGNC:FUS, var("?")) positiveCorrelation path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:27181519 | p(HGNC:FUS, var("?")) negativeCorrelation bp(GO:autophagy) |
| pubmed:27181519 | p(HGNC:FUS, var("?")) decreases bp(GO:autophagy) |
| pubmed:27181519 | p(HGNC:FUS, var("?")) decreases bp(GO:"motor neuron apoptotic process") |
| pubmed:27181519 | p(HGNC:FUS, var("?")) increases bp(GO:"cell death") |
| pubmed:27181519 | p(HGNC:FUS, var("?")) decreases a(MESH:Neurites) |
| pubmed:22372633 | path(MESH:"Muscle Denervation") positiveCorrelation p(HGNC:HDAC6) |
| pubmed:22372633 | path(MESH:"Muscle Denervation") negativeCorrelation a(MESH:Axons) |
| pubmed:30935091 | p(HGNC:HSPB1) decreases bp(MESH:"Oxidative Stress") |
| pubmed:30935091 | p(HGNC:HSPB1) increases bp(MESH:"Cell Survival") |
| pubmed:27491084 | p(HGNC:HSPB1) association a(CONSO:"amyloid-beta aggregates") |
| pubmed:21882945 | p(HGNC:HSPB1) increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") |
| pubmed:21882945 | p(HGNC:HSPB1) increases bp(GO:"proteasomal protein catabolic process") |
| pubmed:21882945 | p(HGNC:HSPB1) increases bp(GO:autophagy) |
| pubmed:21882945 | p(HGNC:HSPB1) directlyIncreases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) |
| pubmed:14963027 | p(HGNC:HSPB1) increases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) |
| pubmed:21882945 | p(HGNC:HSPB1) directlyIncreases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:21882945 | p(HGNC:HSPB1) increases p(HGNC:MAPT) |
| pubmed:21882945 | p(HGNC:HSPB1) decreases p(HGNC:MAPT) |
| pubmed:21882945 | p(HGNC:HSPB1) directlyIncreases complex(a(MESH:"Neurofibrillary Tangles"), p(HGNC:HSPB1)) |
| pubmed:21882945 | p(HGNC:HSPB1) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pubmed:14963027 | p(HGNC:HSPB1) association p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:14963027 | p(HGNC:HSPB1) decreases act(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) |
| pubmed:14963027 | p(HGNC:HSPB1) decreases complex(p(HGNC:HSPB1), p(HGNC:MAPT)) |
| pubmed:14963027 | p(HGNC:HSPB1) increases complex(p(CONSO:"paired helical filaments"), p(HGNC:HSPB1)) |
| pubmed:14963027 | p(HGNC:HSPB1) negativeCorrelation bp(GO:"neuron apoptotic process") |
| pubmed:29844403 | a(PUBCHEM:132157820) decreases p(HGNC:HDAC6) |
| pubmed:29844403 | a(PUBCHEM:132157820) directlyDecreases act(p(HGNC:HDAC6)) |
| pubmed:29844403 | a(PUBCHEM:132157820) increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:29844403 | a(PUBCHEM:132157820) increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:29844403 | a(PUBCHEM:132157820) causesNoChange p(MESH:Histones, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:29844403 | a(PUBCHEM:132157820) decreases path(MESH:"Cytotoxicity, Immunologic") |
| pubmed:29844403 | a(PUBCHEM:132157820) decreases bp(GO:"cell death") |
| pubmed:29844403 | a(PUBCHEM:132157820) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:29844403 | a(PUBCHEM:132157820) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:29844403 | a(PUBCHEM:132157820) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:29844403 | a(PUBCHEM:132157820) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:29844403 | a(PUBCHEM:132157820) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:29844403 | a(PUBCHEM:132157820) decreases p(HGNC:MAPT, loc(CONSO:"Tau aggregates")) |
| pubmed:29844403 | a(PUBCHEM:132157820) increases deg(p(HGNC:MAPT)) |
| pubmed:29844403 | a(PUBCHEM:132157820) increases p(HGNCGENEFAMILY:"Heat shock 90kDa proteins", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:29844403 | a(PUBCHEM:132157820) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:29844403 | a(PUBCHEM:132157820) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:29844403 | a(PUBCHEM:132157820) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:29844403 | a(PUBCHEM:132157820) causesNoChange p(HGNC:CDK5) |
| pubmed:29844403 | a(PUBCHEM:132157820) causesNoChange p(HGNC:CDK5R1) |
| pubmed:29844403 | a(PUBCHEM:132157820) increases p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29844403 | a(PUBCHEM:132157820) decreases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 216)) |
| pubmed:29844403 | a(PUBCHEM:132157820) decreases act(p(HGNC:GSK3B)) |
| pubmed:29844403 | a(PUBCHEM:132157820) increases bp(GO:memory) |
| pubmed:29844403 | a(PUBCHEM:132157820) increases bp(GO:memory) |
| pubmed:29844403 | a(PUBCHEM:132157820) decreases path(DOID:"Alzheimer's disease") |
| pubmed:29844403 | a(PUBCHEM:132157820) increases tloc(a(PUBCHEM:132157820), fromLoc(MESH:Blood), toLoc(MESH:Brain)) |
| pubmed:29844403 | a(PUBCHEM:132157820) increases bp(GO:learning) |
| pubmed:29844403 | a(PUBCHEM:132157820) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29844403 | a(PUBCHEM:132157820) decreases a(CONSO:"Tau aggregates") |
| pubmed:29844403 | a(PUBCHEM:132157820) increases p(INTERPRO:"Heat shock protein Hsp90 family", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:29844403 | a(PUBCHEM:132157820) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:30837838 | p(MESH:Histones) association path(MESH:"Chromatin Assembly and Disassembly") |
| pubmed:29844403 | path(HP:"Abnormal synaptic transmission") increases bp(GO:"neuron death") |
| pubmed:29844403 | p(CONSO:APP695, var("?")) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:29844403 | p(CONSO:APP695, var("?")) increases p(HGNC:MAPT, loc(GO:cytosol)) |
| pubmed:29844403 | p(CONSO:APP695, var("?")) increases p(HGNC:MAPT, loc(CONSO:"Tau aggregates")) |
| pubmed:29844403 | p(CONSO:APP695, var("?")) increases complex(p(HGNC:HDAC6), p(HGNCGENEFAMILY:"Heat shock 90kDa proteins")) |
| pubmed:29844403 | p(CONSO:APP695, var("?")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:29844403 | p(CONSO:APP695, var("?")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:29844403 | p(CONSO:APP695, var("?")) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:29844403 | p(CONSO:APP695, var("?")) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) |
| pubmed:29844403 | p(CONSO:"Tau oligomers") increases p(CONSO:"Tau fibrils") |
| pubmed:25478017 | p(CONSO:"Tau oligomers") increases path(MESH:Tauopathies) |
| pubmed:26751493 | p(CONSO:"Tau oligomers") association bp(GO:"clathrin-dependent endocytosis") |
| pubmed:27299292 | path(DOID:neuropathy) negativeCorrelation p(HGNC:TFEB) |
| pubmed:29844403 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0016567 ! "protein ubiquitination")) increases deg(p(HGNC:MAPT)) |
| pubmed:29844403 | a(PUBCHEM:462382) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:25546293 | a(PUBCHEM:462382) decreases p(FPLX:Proteasome) |
| pubmed:25546293 | a(PUBCHEM:462382) increases p(HGNC:CTNNB1, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:25546293 | a(PUBCHEM:462382) increases p(HGNC:CTNNB1) |
| pubmed:30935091 | a(PUBCHEM:462382) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0016567 ! "protein ubiquitination", Lys, 49)) |
| pubmed:30935091 | a(PUBCHEM:462382) increases p(HGNCGENEFAMILY:"Beta catenins") |
| pubmed:29844403 | p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) association act(p(HGNC:GSK3B)) |
| doi:"10.4172/2168-975X.1000126" | p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) decreases act(p(HGNC:GSK3B)) |
| pubmed:25331948 | p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) decreases act(p(HGNC:GSK3B)) |
| pubmed:22419736 | p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) decreases act(p(HGNC:GSK3B)) |
| pubmed:24183963 | p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:29121589 | p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:29844403 | p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) directlyDecreases act(p(HGNC:GSK3B)) |
| pubmed:29844403 | p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:26979166 | p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) decreases act(p(HGNC:PRKACA), ma(go:0016301 ! "kinase activity")) |
| pubmed:29844403 | p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Tyr, 216)) association act(p(HGNC:GSK3B)) |
| pubmed:29844403 | p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:25514383 | p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) decreases bp(GO:"apoptotic process") |
| pubmed:30697142 | p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) increases bp(MESH:Neuroprotection) |
| pubmed:30697142 | p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) decreases p(HGNC:GSK3B) |
| pubmed:30697142 | p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(HGNC:CREBBP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:30985105 | p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) decreases bp(GO:autophagy) |
| pubmed:25546293 | a(PUBCHEM:5311) decreases p(MESH:"Histone Deacetylases") |
| pubmed:25546293 | a(PUBCHEM:5311) increases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) |
| pubmed:30935091 | a(PUBCHEM:5311) decreases p(HGNC:HDAC6) |
| pubmed:30935091 | a(PUBCHEM:5311) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006473 ! "protein acetylation", Lys, 49)) |
| pubmed:30935091 | a(PUBCHEM:5311) causesNoChange p(HGNCGENEFAMILY:"Beta catenins") |
| pubmed:25546293 | p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) increases complex(p(HGNC:CSNK1A1), p(HGNC:CTNNB1)) |
| pubmed:25546293 | p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) increases complex(p(HGNC:CSNK1A1), p(HGNC:CTNNB1)) |
| pubmed:25546293 | p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) increases complex(p(HGNC:CTNNB1), p(HGNC:GSK3B)) |
| pubmed:25546293 | p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) increases act(p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)), ma(GO:"cadherin binding")) |
| pubmed:25546293 | p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) positiveCorrelation p(HGNC:CTNNB1, loc(GO:"plasma membrane")) |
| pubmed:25546293 | p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) increases p(HGNC:CTNNB1, loc(GO:nucleus)) |
| pubmed:25546293 | p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) increases p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 45)) |
| pubmed:25546293 | p(HGNC:CTNNB1, loc(GO:"plasma membrane")) positiveCorrelation p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) |
| pubmed:18494933 | deg(p(HGNC:CTNNB1)) positiveCorrelation p(HGNC:DKK1) |
| pubmed:25546293 | a(CONSO:crebinostat) decreases p(HGNC:HDAC1) |
| pubmed:25546293 | a(CONSO:crebinostat) decreases p(HGNC:HDAC2) |
| pubmed:25546293 | a(CONSO:crebinostat) decreases p(HGNC:HDAC3) |
| pubmed:25546293 | a(CONSO:crebinostat) decreases p(HGNC:HDAC6) |
| pubmed:30935091 | a(CONSO:crebinostat) decreases p(HGNC:HDAC6) |
| pubmed:25546293 | a(CONSO:crebinostat) increases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) |
| pubmed:30935091 | a(CONSO:crebinostat) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006473 ! "protein acetylation", Lys, 49)) |
| pubmed:30935091 | a(CONSO:crebinostat) causesNoChange p(HGNCGENEFAMILY:"Beta catenins") |
| pubmed:27209302 | p(HGNC:HDAC1) decreases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30640040 | p(HGNC:HDAC1) association a(PUBCHEM:4261) |
| pubmed:18305152 | p(HGNC:HDAC1) association act(p(HGNC:RB1)) |
| pubmed:27209302 | p(HGNC:HDAC2) decreases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30640040 | p(HGNC:HDAC3) association a(PUBCHEM:4261) |
| pubmed:28771976 | p(HGNC:HDAC3) increases a(CHEBI:amyloid-beta) |
| pubmed:28771976 | p(HGNC:HDAC3) increases bp(GO:"microglial cell activation") |
| pubmed:28771976 | p(HGNC:HDAC3) decreases a(GO:"dendritic spine") |
| pubmed:25546293 | a(PUBCHEM:10487) decreases p(HGNC:HDAC1) |
| pubmed:25546293 | a(PUBCHEM:10487) decreases p(HGNC:HDAC2) |
| pubmed:25546293 | a(PUBCHEM:10487) decreases p(HGNC:HDAC3) |
| pubmed:25546293 | a(PUBCHEM:10487) causesNoChange p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) |
| pubmed:25546293 | a(PUBCHEM:16773791) decreases p(HGNC:HDAC3) |
| pubmed:25546293 | a(PUBCHEM:16773791) causesNoChange p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) |
| pubmed:30935091 | a(PUBCHEM:16773791) decreases p(HGNCGENEFAMILY:"Histone deacetylases, class I") |
| pubmed:30935091 | a(PUBCHEM:16773791) causesNoChange p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006473 ! "protein acetylation", Lys, 49)) |
| pubmed:25546293 | a(PUBCHEM:6675804) decreases p(HGNC:HDAC6) |
| pubmed:25546293 | a(PUBCHEM:6675804) increases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) |
| pubmed:25546293 | a(PUBCHEM:49850262) decreases p(HGNC:HDAC6) |
| pubmed:30935091 | a(PUBCHEM:49850262) decreases p(HGNC:HDAC6) |
| pubmed:30935091 | a(PUBCHEM:49850262) decreases p(HGNC:HDAC6) |
| pubmed:24844691 | a(PUBCHEM:49850262) directlyDecreases act(p(HGNC:HDAC6)) |
| pubmed:25546293 | a(PUBCHEM:49850262) increases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) |
| pubmed:30935091 | a(PUBCHEM:49850262) increases bp(GO:"learning or memory") |
| pubmed:30935091 | a(PUBCHEM:49850262) decreases p(HGNC:MAPT) |
| pubmed:30935091 | a(PUBCHEM:49850262) decreases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) |
| pubmed:30935091 | a(PUBCHEM:49850262) association p(MESH:"Amyloidogenic Proteins") |
| pubmed:30935091 | a(PUBCHEM:49850262) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30935091 | a(PUBCHEM:49850262) increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30935091 | a(PUBCHEM:49850262) increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30935091 | a(PUBCHEM:49850262) positiveCorrelation bp(GO:"axonal transport") |
| pubmed:30935091 | a(PUBCHEM:49850262) positiveCorrelation bp(GO:"axonal transport") |
| pubmed:30935091 | a(PUBCHEM:49850262) increases bp(GO:"motor behavior") |
| pubmed:30935091 | a(PUBCHEM:49850262) decreases p(HGNC:MAPT, pmod(CONSO:"protein aggregates"), pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30935091 | a(PUBCHEM:49850262) decreases p(HGNC:HDAC6, pmod(CONSO:"protein aggregates")) |
| pubmed:30935091 | a(PUBCHEM:49850262) increases p(HGNC:HSPB1) |
| pubmed:30935091 | a(PUBCHEM:49850262) increases p(HGNCGENEFAMILY:"Heat shock 70kDa proteins") |
| pubmed:24844691 | a(PUBCHEM:49850262) increases bp(GO:behavior) |
| pubmed:24844691 | a(PUBCHEM:49850262) decreases a(CHEBI:amyloid-beta) |
| pubmed:24844691 | a(PUBCHEM:49850262) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:24844691 | a(PUBCHEM:49850262) increases p(FPLX:Tubulin, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:24844691 | a(PUBCHEM:49850262) increases bp(GO:autophagy) |
| pubmed:25546293 | a(PUBCHEM:53340666) decreases p(HGNC:HDAC6) |
| pubmed:30935091 | a(PUBCHEM:53340666) decreases p(HGNC:HDAC6) |
| pubmed:30935091 | a(PUBCHEM:53340666) decreases p(HGNC:HDAC6) |
| pubmed:30935091 | a(PUBCHEM:53340666) decreases p(HGNC:HDAC6) |
| pubmed:30640040 | a(PUBCHEM:53340666) association p(HGNC:HDAC6) |
| pubmed:24844691 | a(PUBCHEM:53340666) directlyDecreases act(p(HGNC:HDAC6)) |
| pubmed:25546293 | a(PUBCHEM:53340666) increases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) |
| pubmed:25546293 | a(PUBCHEM:53340666) increases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49), loc(GO:"plasma membrane")) |
| pubmed:25546293 | a(PUBCHEM:53340666) increases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49), loc(GO:cytoplasm)) |
| pubmed:25546293 | a(PUBCHEM:53340666) decreases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49), loc(GO:nucleus)) |
| pubmed:25546293 | a(PUBCHEM:53340666) increases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) |
| pubmed:25546293 | a(PUBCHEM:53340666) causesNoChange p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 33)) |
| pubmed:25546293 | a(PUBCHEM:53340666) causesNoChange p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 37)) |
| pubmed:25546293 | a(PUBCHEM:53340666) causesNoChange p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 41)) |
| pubmed:25546293 | a(PUBCHEM:53340666) causesNoChange p(HGNC:CTNNB1, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:25546293 | a(PUBCHEM:53340666) increases p(HGNC:CTNNB1, loc(GO:"plasma membrane")) |
| pubmed:25546293 | a(PUBCHEM:53340666) causesNoChange act(p(HGNC:CTNNB1), ma(GO:"cadherin binding")) |
| pubmed:30935091 | a(PUBCHEM:53340666) association p(MESH:"Amyloidogenic Proteins") |
| pubmed:30935091 | a(PUBCHEM:53340666) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30935091 | a(PUBCHEM:53340666) increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30935091 | a(PUBCHEM:53340666) increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30935091 | a(PUBCHEM:53340666) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006473 ! "protein acetylation", Lys, 49)) |
| pubmed:30935091 | a(PUBCHEM:53340666) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006473 ! "protein acetylation", Lys, 49), loc(GO:"plasma membrane")) |
| pubmed:30935091 | a(PUBCHEM:53340666) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006473 ! "protein acetylation", Lys, 49), loc(GO:cytoplasm)) |
| pubmed:30935091 | a(PUBCHEM:53340666) increases complex(p(HGNC:CDH2), p(HGNCGENEFAMILY:"Beta catenins"), loc(GO:"plasma membrane")) |
| pubmed:30935091 | a(PUBCHEM:53340666) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30270813 | a(PUBCHEM:53340666) decreases path(EFO:"peripheral neuropathy") |
| pubmed:30270813 | a(PUBCHEM:53340666) causesNoChange bp(GO:cognition) |
| pubmed:30640040 | a(PUBCHEM:53340666) increases a(CONSO:"Tau aggregates") |
| pubmed:24844691 | a(PUBCHEM:53340666) increases bp(GO:behavior) |
| pubmed:24844691 | a(PUBCHEM:53340666) decreases a(CHEBI:amyloid-beta) |
| pubmed:24844691 | a(PUBCHEM:53340666) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:24844691 | a(PUBCHEM:53340666) increases p(FPLX:Tubulin, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:24844691 | a(PUBCHEM:53340666) increases bp(GO:autophagy) |
| pubmed:25546293 | p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 45)) decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:25546293 | p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 45)) causesNoChange p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 33)) |
| pubmed:25546293 | p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 45)) causesNoChange p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 37)) |
| pubmed:25546293 | p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 45)) causesNoChange p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 41)) |
| pubmed:25546293 | p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 33)) increases complex(p(HGNC:BTRC), p(HGNC:CTNNB1)) |
| pubmed:25546293 | p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 33)) increases deg(p(HGNC:CTNNB1)) |
| pubmed:25546293 | p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 37)) increases complex(p(HGNC:BTRC), p(HGNC:CTNNB1)) |
| pubmed:25546293 | p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 37)) increases deg(p(HGNC:CTNNB1)) |
| pubmed:25546293 | p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 41)) increases complex(p(HGNC:BTRC), p(HGNC:CTNNB1)) |
| pubmed:25546293 | p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 41)) increases deg(p(HGNC:CTNNB1)) |
| pubmed:25546293 | complex(p(HGNC:CSNK1A1), p(HGNC:CTNNB1)) increases act(p(HGNC:CSNK1A1), ma(go:0016301 ! "kinase activity")) |
| pubmed:25546293 | act(p(HGNC:CSNK1A1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 45)) |
| pubmed:30935091 | p(HGNC:CSNK1A1) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation", Ser, 45)) |
| pubmed:30444369 | p(HGNC:CSNK1A1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30444369 | p(HGNC:CSNK1A1) regulates act(p(FPLX:"Gamma_secretase")) |
| pubmed:30444369 | p(HGNC:CSNK1A1) increases bp(GO:"amyloid-beta formation") |
| pubmed:25974414 | act(p(HGNC:CSNK1A1), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:25673844 | p(HGNC:CSNK1A1) isA p(FPLX:CSNK1) |
| pubmed:30837838 | p(HGNC:CSNK1A1) increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 379)) |
| pubmed:30837838 | p(HGNC:CSNK1A1) increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 403)) |
| pubmed:30837838 | p(HGNC:CSNK1A1) increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:30837838 | p(HGNC:CSNK1A1) increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 409)) |
| pubmed:30837838 | p(HGNC:CSNK1A1) increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 410)) |
| pubmed:25546293 | p(HGNC:CTNNB1, pmod(go:0016567 ! "protein ubiquitination", Lys, 49)) increases act(p(FPLX:Proteasome)) |
| pubmed:25546293 | act(p(FPLX:Proteasome)) increases deg(p(HGNC:CTNNB1)) |
| pubmed:23746257 | p(FPLX:Proteasome) increases bp(GO:"protein catabolic process") |
| pubmed:26195256 | act(p(FPLX:Proteasome)) increases bp(GO:"protein catabolic process") |
| pubmed:23746257 | p(FPLX:Proteasome) increases bp(GO:"protein unfolding") |
| pubmed:25784053 | p(FPLX:Proteasome) increases bp(MESH:Proteolysis) |
| pubmed:25784053 | p(FPLX:Proteasome) decreases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:25784053 | act(p(FPLX:Proteasome)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:30145931 | act(p(FPLX:Proteasome)) decreases path(CONSO:neurotoxicity) |
| pubmed:30145931 | act(p(FPLX:Proteasome)) decreases p(HGNC:MAPT) |
| pubmed:30145931 | act(p(FPLX:Proteasome)) increases deg(p(HGNC:MAPT, loc(MESH:Dendrites))) |
| pubmed:26195256 | act(p(FPLX:Proteasome)) increases deg(p(HGNC:MAPT)) |
| pubmed:30145931 | act(p(FPLX:Proteasome)) increases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356))) |
| pubmed:29311797 | act(p(FPLX:Proteasome)) negativeCorrelation path(MESH:"Neurodegenerative Diseases") |
| pubmed:26195256 | act(p(FPLX:Proteasome)) increases deg(a(CHEBI:amyloid-beta, loc(GO:intracellular))) |
| pubmed:22941973 | act(p(FPLX:Proteasome)) increases deg(p(RGD:Syp)) |
| pubmed:24964035 | act(p(FPLX:Proteasome)) increases deg(p(HGNC:SMAD2)) |
| pubmed:25546293 | p(HGNC:CTNNB1, pmod(go:0016567 ! "protein ubiquitination")) increases deg(p(HGNC:CTNNB1)) |
| pubmed:25546293 | bp(GO:"epidermal growth factor receptor signaling pathway") decreases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) |
| pubmed:25546293 | bp(GO:"epidermal growth factor receptor signaling pathway") increases p(HGNC:CTNNB1, loc(GO:nucleus)) |
| pubmed:25546293 | act(p(HGNC:KAT2B)) increases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) |
| pubmed:25546293 | act(p(HGNC:KAT2B)) increases p(HGNC:CTNNB1, loc(GO:nucleus)) |
| pubmed:25672970 | act(p(HGNC:KAT2B)) increases p(FPLX:NFkappaB, pmod(go:0006473 ! "protein acetylation", Lys, 122)) |
| pubmed:24686445 | act(p(HGNC:KAT2B)) increases p(CONSO:"Histone H3", pmod(go:0006473 ! "protein acetylation", Lys, 9)) |
| pubmed:25546293 | complex(p(HGNC:BTRC), p(HGNC:CTNNB1)) increases act(p(HGNC:BTRC), ma(GO:"ubiquitin protein ligase activity")) |
| pubmed:25546293 | p(HGNC:HDAC6, pmod(go:0006473 ! "protein acetylation", Lys, 49)) decreases p(HGNC:CTNNB1, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:25546293 | p(HGNC:HDAC6, pmod(go:0006473 ! "protein acetylation", Ser, 45)) decreases p(HGNC:CTNNB1, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:30935091 | p(HGNC:SOD1, var("p.Gly93Ala")) decreases p(HGNC:HDAC6) |
| pubmed:30515821 | p(HGNC:SOD1, var("p.Gly93Ala")) increases path(DOID:"muscular atrophy") |
| pubmed:26996954 | path(MESH:"Amyloid Neuropathies") association g(DBSNP:rs3824968) |
| pubmed:30935091 | p(MESH:"Amyloidogenic Proteins") association a(PUBCHEM:53340666) |
| pubmed:30935091 | p(MESH:"Amyloidogenic Proteins") association a(PUBCHEM:49850262) |
| pubmed:30935091 | p(HGNC:AKT2) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:30935091 | a(PUBCHEM:57382288) positiveCorrelation bp(GO:"axonal transport") |
| pubmed:30935091 | path(DOID:"Charcot-Marie-Tooth disease") negativeCorrelation bp(GO:"axonal transport") |
| pubmed:30935091 | path(DOID:"Charcot-Marie-Tooth disease") increases p(HGNC:GARS, var("?")) |
| pubmed:30935091 | p(HGNC:GARS, var("?")) negativeCorrelation bp(GO:"axonal transport") |
| pubmed:30935091 | p(HGNC:GARS, var("?")) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30935091 | path(DOID:"Rett syndrome") increases p(HGNC:HDAC6) |
| pubmed:30935091 | path(DOID:"Rett syndrome") decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:26979166 | path(DOID:"Rett syndrome") isA path(HP:Autism) |
| pubmed:30935091 | p(HGNC:MECP2, var("?")) negativeCorrelation bp(GO:"synaptic transmission, GABAergic") |
| pubmed:30935091 | p(HGNC:MECP2, var("?")) increases p(HGNC:HDAC6) |
| pubmed:30935091 | p(HGNC:MECP2, var("?")) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30935091 | bp(GO:"synaptic transmission, GABAergic") negativeCorrelation p(HGNC:MECP2, var("?")) |
| pubmed:29428175 | bp(GO:"synaptic transmission, GABAergic") association p(MESH:"Receptors, Glutamate", loc(GO:"postsynaptic membrane")) |
| pubmed:30935091 | a(CHEBI:"valproic acid") decreases p(MESH:"Histone Deacetylases") |
| pubmed:30935091 | a(CHEBI:"sodium butyrate") decreases p(HGNC:HDAC6) |
| pubmed:30935091 | a(PUBCHEM:4261) decreases p(HGNC:HDAC6) |
| pubmed:30935091 | a(PUBCHEM:4261) decreases p(HGNCGENEFAMILY:"Histone deacetylases, class I") |
| pubmed:30935091 | a(PUBCHEM:4261) decreases p(HGNCGENEFAMILY:"Histone deacetylases, class I") |
| pubmed:30935091 | a(PUBCHEM:4261) decreases path(DOID:"antisocial personality disorder") |
| pubmed:30935091 | a(PUBCHEM:4261) causesNoChange p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006473 ! "protein acetylation", Lys, 49)) |
| pubmed:30640040 | a(PUBCHEM:4261) increases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:4261) association p(HGNC:HDAC1) |
| pubmed:30640040 | a(PUBCHEM:4261) association p(HGNC:HDAC3) |
| pubmed:30935091 | a(PUBCHEM:134164107) decreases p(HGNC:HDAC6) |
| pubmed:30935091 | a(PUBCHEM:134164107) regulates path(MESH:Affect) |
| pubmed:30935091 | a(PUBCHEM:134164107) regulates bp(GO:"gene expression") |
| pubmed:30935091 | a(CHEBI:fluoxetine) decreases path(DOID:"antisocial personality disorder") |
| pubmed:30935091 | a(CHEBI:fluoxetine) increases p(HGNCGENEFAMILY:"Beta catenins", loc(GO:"plasma membrane")) |
| pubmed:30935091 | a(CHEBI:fluoxetine) causesNoChange p(HGNCGENEFAMILY:"Beta catenins", loc(GO:nucleus)) |
| pubmed:30935091 | a(CHEBI:fluoxetine) increases p(HGNC:CDH2) |
| pubmed:19721446 | a(CHEBI:fluoxetine) decreases a(CHEBI:monoamine) |
| pubmed:19721446 | a(CHEBI:fluoxetine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:30027901 | a(CHEBI:fluoxetine) isA a(MESH:"Antidepressive Agents") |
| pubmed:30027901 | a(CHEBI:fluoxetine) decreases path(MESH:"Huntington Disease") |
| pubmed:30027901 | a(CHEBI:fluoxetine) causesNoChange bp(GO:cognition) |
| pubmed:26979166 | path(MESH:Affect) positiveCorrelation a(CHEBI:monoamine) |
| pubmed:21787755 | path(MESH:Affect) association p(CONSO:"alpha-6-containing nAChR") |
| pubmed:30935091 | p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation")) increases complex(complex(GO:"proteasome complex"), p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:30935091 | p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation")) increases complex(complex(GO:"SCF ubiquitin ligase complex"), p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:30935091 | p(HGNCGENEFAMILY:"Beta catenins") increases tloc(p(HGNCGENEFAMILY:"Beta catenins"), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:30935091 | p(HGNCGENEFAMILY:"Beta catenins", loc(GO:nucleus)) increases complex(p(HGNCGENEFAMILY:"Beta catenins"), p(HGNCGENEFAMILY:"TCF/LEF transcription factor family")) |
| pubmed:30935091 | p(HGNCGENEFAMILY:"Beta catenins") increases bp(GO:"dendrite development") |
| pubmed:30935091 | p(HGNCGENEFAMILY:"Beta catenins") increases bp(GO:"neuronal signal transduction") |
| pubmed:30935091 | p(HGNCGENEFAMILY:"Beta catenins") increases complex(complex(GO:"actin cytoskeleton"), p(HGNC:CDH2)) |
| pubmed:30935091 | p(HGNCGENEFAMILY:"Beta catenins") increases bp(GO:"synaptic vesicle membrane organization") |
| pubmed:30935091 | p(HGNCGENEFAMILY:"Beta catenins") regulates bp(GO:"synaptic vesicle localization") |
| pubmed:30935091 | complex(complex(GO:"proteasome complex"), p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation"))) increases deg(p(HGNCGENEFAMILY:"Beta catenins")) |
| pubmed:30935091 | complex(complex(GO:"SCF ubiquitin ligase complex"), p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation"))) increases deg(p(HGNCGENEFAMILY:"Beta catenins")) |
| pubmed:14556719 | complex(GO:"SCF ubiquitin ligase complex") increases p(HGNC:CCNE1, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:30935091 | complex(p(HGNC:LRP1), p(HGNCGENEFAMILY:"Wnt family")) increases p(HGNC:AXIN1) |
| pubmed:26195256 | p(HGNC:LRP1) increases tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:Brain), toLoc(MESH:Blood)) |
| pubmed:26195256 | p(HGNC:LRP1) increases tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Brain)) |
| pubmed:26195256 | p(HGNC:LRP1) increases tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Cardiovascular System")) |
| pubmed:29626319 | p(HGNC:LRP1) increases tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:Brain), toLoc(MESH:Blood)) |
| pubmed:29626319 | p(HGNC:LRP1) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | p(HGNC:LRP1) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:26195256 | p(HGNC:LRP1) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26195256 | p(HGNC:LRP1) increases tloc(p(HGNC:APOE), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Cardiovascular System")) |
| pubmed:30935091 | p(HGNC:AXIN1) increases deg(complex(p(HGNC:APC), p(HGNC:AXIN1), p(HGNC:GSK3B), p(HGNCGENEFAMILY:"Beta catenins"))) |
| pubmed:30935091 | p(HGNC:AXIN1) increases p(HGNCGENEFAMILY:"Beta catenins") |
| pubmed:30935091 | complex(p(HGNCGENEFAMILY:"Beta catenins"), p(HGNCGENEFAMILY:"TCF/LEF transcription factor family")) increases bp(GO:"mRNA transcription") |
| pubmed:30935091 | path(EFO:"Thyroid Gland Undifferentiated (Anaplastic) Carcinoma") increases p(HGNCGENEFAMILY:"Beta catenins", var("p.Lys49Arg")) |
| pubmed:30935091 | p(HGNCGENEFAMILY:"Beta catenins", var("p.Lys49Arg")) increases p(HGNCGENEFAMILY:"Beta catenins", loc(GO:nucleus)) |
| pubmed:30935091 | p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006473 ! "protein acetylation", Lys, 49)) decreases act(p(HGNC:EGF)) |
| pubmed:30935091 | p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006473 ! "protein acetylation", Lys, 49)) decreases p(HGNCGENEFAMILY:"Beta catenins", loc(GO:nucleus)) |
| pubmed:30935091 | p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0016567 ! "protein ubiquitination", Lys, 49)) increases deg(p(HGNCGENEFAMILY:"Beta catenins")) |
| pubmed:30935091 | complex(p(HGNC:CDH2), p(HGNCGENEFAMILY:"Beta catenins")) increases bp(GO:"cell-cell adhesion") |
| pubmed:30935091 | complex(p(HGNC:CDH2), p(HGNCGENEFAMILY:"Beta catenins")) increases p(HGNCGENEFAMILY:"PDZ domain containing") |
| pubmed:30935091 | a(CHEBI:ketamine) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser)) |
| pubmed:30935091 | p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser)) isA a(MESH:"Antidepressive Agents") |
| pubmed:30935091 | p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser)) decreases act(p(HGNC:GSK3B)) |
| pubmed:30935091 | a(CHEBI:ketanserin) decreases p(HGNC:HTR2A) |
| pubmed:30935091 | a(CHEBI:ketanserin) increases p(HGNCGENEFAMILY:"Beta catenins", loc(GO:"plasma membrane")) |
| pubmed:30935091 | a(CHEBI:ketanserin) causesNoChange p(HGNCGENEFAMILY:"Beta catenins", loc(GO:nucleus)) |
| pubmed:30935091 | a(CHEBI:ketanserin) increases p(HGNC:CDH2) |
| pubmed:30935091 | bp(GO:"synapse assembly") association p(HGNC:HDAC6) |
| pubmed:30935091 | bp(GO:"synapse assembly") positiveCorrelation p(HGNC:AKT1) |
| pubmed:21214928 | bp(GO:"synapse assembly") association p(HGNC:APP) |
| pubmed:30106381 | bp(GO:"synapse assembly") association p(HGNC:ADNP) |
| pubmed:27807169 | bp(GO:"synapse assembly") positiveCorrelation p(RGD:Cdk5r2) |
| pubmed:30935091 | p(HGNC:AKT1) positiveCorrelation bp(GO:"synapse assembly") |
| pubmed:30935091 | p(HGNC:AKT1) increases bp(GO:"dendritic spine morphogenesis") |
| pubmed:30935091 | act(p(HGNC:AKT1), ma(GO:"phosphatidylinositol-3,4,5-trisphosphate binding")) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation", Ser, 552)) |
| pubmed:29661268 | act(p(HGNC:AKT1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22530628 | act(p(HGNC:AKT1)) causesNoChange a(CONSO:"amyloid-beta aggregates") |
| pubmed:22530628 | act(p(HGNC:AKT1)) decreases bp(GO:"neuron death") |
| pubmed:22530628 | act(p(HGNC:AKT1)) increases bp(MESH:"Neuronal Plasticity") |
| pubmed:22530628 | p(HGNC:AKT1) increases bp(MESH:"Neuronal Plasticity") |
| pubmed:22530628 | act(p(HGNC:AKT1)) increases bp(MESH:"Long-Term Potentiation") |
| pubmed:22530628 | act(p(HGNC:AKT1)) increases p(HGNC:BCL2) |
| pubmed:22530628 | act(p(HGNC:AKT1)) increases p(HGNC:CREBBP) |
| pubmed:22530628 | act(p(HGNC:AKT1)) increases p(HGNC:DBF4) |
| pubmed:22530628 | p(HGNC:AKT1) increases bp(GO:cognition) |
| pubmed:22530628 | p(HGNC:AKT1) increases bp(GO:"learning or memory") |
| pubmed:29428175 | act(p(HGNC:AKT1), ma(GO:"GTPase activity")) regulates bp(MESH:"Cell Movement") |
| pubmed:26979166 | act(p(HGNC:AKT1)) directlyIncreases act(p(HGNC:CREB1)) |
| pubmed:30606258 | act(p(HGNC:AKT1)) decreases p(HGNC:GSK3B) |
| pubmed:30606258 | act(p(HGNC:AKT1)) association bp(GO:"regulation of insulin receptor signaling pathway") |
| pubmed:26968346 | p(HGNC:AKT1) decreases p(HGNC:TFEB) |
| pubmed:21882945 | p(HGNC:AKT1) association complex(p(FPLX:HSP90), p(HGNC:STUB1)) |
| pubmed:21882945 | p(HGNC:AKT1) negativeCorrelation deg(p(HGNC:MAPT)) |
| pubmed:21367866 | act(p(HGNC:AKT1), ma(go:0016301 ! "kinase activity")) positiveCorrelation complex(p(FPLX:HSP90), p(HGNC:CDC37)) |
| pubmed:21367866 | act(p(HGNC:AKT1), ma(go:0016301 ! "kinase activity")) negativeCorrelation p(HGNC:CDC37) |
| pubmed:30935091 | p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation", Ser, 552)) increases p(HGNCGENEFAMILY:"Beta catenins", loc(GO:"plasma membrane")) |
| pubmed:30270813 | a(CHEBI:cisplatin) negativeCorrelation path(EFO:neoplasm) |
| pubmed:30270813 | a(CHEBI:cisplatin) decreases path(MESH:"Spatial Memory") |
| pubmed:30270813 | a(CHEBI:cisplatin) decreases path(MESH:"Spatial Memory") |
| pubmed:30270813 | a(CHEBI:cisplatin) increases path(EFO:"peripheral neuropathy") |
| pubmed:30270813 | a(CHEBI:cisplatin) negativeCorrelation bp(GO:cognition) |
| pubmed:30270813 | a(CHEBI:cisplatin) causesNoChange bp(GO:"locomotory behavior") |
| pubmed:30270813 | a(CHEBI:cisplatin) decreases path(MESH:"Executive Function") |
| pubmed:30270813 | a(CHEBI:cisplatin) decreases path(MESH:"Problem Solving") |
| pubmed:30270813 | a(CHEBI:cisplatin) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30270813 | a(CHEBI:cisplatin) causesNoChange p(HGNC:HDAC6) |
| pubmed:30270813 | a(CHEBI:cisplatin) increases bp(MESH:"Mitochondrial Size") |
| pubmed:30270813 | a(CHEBI:cisplatin) negativeCorrelation bp(GO:"cristae formation") |
| pubmed:30270813 | a(CHEBI:cisplatin) decreases path(MESH:"Energy Metabolism") |
| pubmed:30270813 | a(CHEBI:cisplatin) decreases path(EFO:"maximal oxygen uptake measurement") |
| pubmed:30270813 | a(CHEBI:cisplatin) causesNoChange bp(GO:"respiratory gaseous exchange by respiratory system") |
| pubmed:30270813 | a(CHEBI:cisplatin) causesNoChange bp(GO:"cellular respiration") |
| pubmed:30270813 | a(CHEBI:cisplatin) decreases p(HGNC:SYP) |
| pubmed:30270813 | a(CHEBI:cisplatin) decreases p(HGNC:DLG4) |
| pubmed:30270813 | a(CHEBI:cisplatin) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30270813 | path(EFO:neoplasm) negativeCorrelation a(CHEBI:cisplatin) |
| pubmed:18305152 | path(EFO:neoplasm) association p(HGNC:CDK6) |
| pubmed:30270813 | a(PUBCHEM:91844718) increases path(MESH:"Spatial Memory") |
| pubmed:30270813 | a(PUBCHEM:91844718) increases path(MESH:"Spatial Memory") |
| pubmed:30270813 | a(PUBCHEM:91844718) decreases path(EFO:"peripheral neuropathy") |
| pubmed:30270813 | a(PUBCHEM:91844718) causesNoChange bp(GO:"locomotory behavior") |
| pubmed:30270813 | a(PUBCHEM:91844718) decreases p(HGNC:HDAC6) |
| pubmed:30270813 | a(PUBCHEM:91844718) increases path(MESH:"Executive Function") |
| pubmed:30270813 | a(PUBCHEM:91844718) increases path(MESH:"Problem Solving") |
| pubmed:30270813 | a(PUBCHEM:91844718) increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30270813 | a(PUBCHEM:91844718) regulates bp(MESH:"Mitochondrial Size") |
| pubmed:30270813 | a(PUBCHEM:91844718) positiveCorrelation bp(GO:"cristae formation") |
| pubmed:30270813 | a(PUBCHEM:91844718) increases path(MESH:"Energy Metabolism") |
| pubmed:30270813 | a(PUBCHEM:91844718) increases path(EFO:"maximal oxygen uptake measurement") |
| pubmed:30270813 | a(PUBCHEM:91844718) causesNoChange bp(GO:"respiratory gaseous exchange by respiratory system") |
| pubmed:30270813 | a(PUBCHEM:91844718) causesNoChange bp(GO:"cellular respiration") |
| pubmed:30270813 | a(PUBCHEM:91844718) increases p(HGNC:SYP) |
| pubmed:30270813 | a(PUBCHEM:91844718) increases p(HGNC:DLG4) |
| pubmed:30270813 | a(PUBCHEM:91844718) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24511233 | path(MESH:"Executive Function") association path(MESH:Schizophrenia) |
| pubmed:30270813 | bp(GO:"cristae formation") negativeCorrelation a(CHEBI:cisplatin) |
| pubmed:30270813 | bp(GO:"cristae formation") positiveCorrelation a(PUBCHEM:91844718) |
| pubmed:30697142 | p(HGNC:DLG4) increases bp(MESH:"Neuronal Plasticity") |
| pubmed:30106381 | p(HGNC:DLG4) regulates act(p(HGNC:ADNP)) |
| pubmed:30664622 | p(HGNC:DLG4) association act(p(HGNC:ADNP)) |
| pubmed:30106381 | p(HGNC:DLG4) regulates act(a(PUBCHEM:9832404)) |
| pubmed:30664622 | p(HGNC:DLG4) association act(a(PUBCHEM:9832404)) |
| pubmed:30106381 | p(HGNC:DLG4) association bp(GO:"regulation of synaptic plasticity") |
| pubmed:24760868 | p(HGNC:DLG4) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pubmed:26751493 | p(HGNC:DLG4) association p(CONSO:"projection domain") |
| pubmed:29540553 | p(MGI:Ep300) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:29540553 | p(MGI:Ep300) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 163)) |
| pubmed:29540553 | p(MGI:Ep300) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 174)) |
| pubmed:29540553 | p(MGI:Ep300) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 274)) |
| pubmed:29540553 | p(MGI:Ep300) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:29540553 | p(MGI:Ep300) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 369)) |
| pubmed:27041503 | p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 274)) decreases bp(MESH:"Long-Term Potentiation") |
| pubmed:27041503 | p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 274)) decreases p(MGI:Wwc1) |
| pubmed:27041503 | p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 274)) decreases bp(GO:"actin cytoskeleton reorganization") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) positiveCorrelation path(DOID:"Alzheimer's disease") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) positiveCorrelation path(DOID:"frontotemporal dementia") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) positiveCorrelation path(DOID:"Niemann-Pick disease") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26390242 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) decreases deg(p(HGNC:MAPT)) |
| pubmed:26390242 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) decreases bp(GO:cognition) |
| pubmed:26390242 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) increases path(CONSO:Neurodegeneration) |
| pubmed:28173111 | p(MGI:Syp) negativeCorrelation p(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Syp) association act(complex(GO:"neuron to neuron synapse")) |
| pubmed:29540553 | composite(p(MGI:Mapt, var("p.Pro301Ser")), p(MGI:Sirt1)) increases p(MGI:Syp) |
| pubmed:28669544 | path(MESH:"Neuronal Plasticity") positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pubmed:28669544 | path(MESH:"Neuronal Plasticity") association path(DOID:"neurodegenerative disease") |
| pubmed:28669544 | path(MESH:"Neuronal Plasticity") directlyDecreases p(HGNC:MBP) |
| pubmed:28669544 | path(MESH:"Neuronal Plasticity") directlyDecreases p(HGNC:DLG4) |
| pubmed:29540553 | composite(p(CONSO:"Tau antibody, MC1"), p(CONSO:"Tau fibrils"), p(MGI:Mapt, var("p.Pro301Ser"))) increases path(EFO:tauopathy) |
| pubmed:29661268 | bp(GO:"microtubule severing") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:29661268 | p(MESH:Phosphotransferases) association p(CONSO:"Tau aggregates", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29661268 | p(CONSO:"Tau aggregates", pmod(go:0006468 ! "protein phosphorylation")) association p(MESH:Phosphotransferases) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys)) decreases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination", Lys)) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys)) decreases deg(p(HGNC:MAPT)) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination", Lys)) increases deg(p(HGNC:MAPT)) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser), loc(CONSO:"KXGS motif")) positiveCorrelation act(p(HGNC:HDAC6)) |
| pubmed:29661268 | p(HGNC:MAPT, var("p.Lys?Gln")) association p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:29661268 | p(HGNC:MAPT, var("p.Lys?Gln")) decreases deg(p(HGNC:MAPT)) |
| pubmed:29661268 | p(HGNC:MAPT, var("p.Lys?Gln")) negativeCorrelation bp(GO:memory) |
| pubmed:29661268 | p(HGNC:MAPT, var("p.Lys?Gln")) negativeCorrelation bp(GO:learning) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) positiveCorrelation path(DOID:"Alzheimer's disease") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) positiveCorrelation path(DOID:"Alzheimer's disease") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) negativeCorrelation bp(GO:memory) |
| pubmed:27041503 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) decreases bp(GO:memory) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) negativeCorrelation bp(GO:"long-term synaptic potentiation") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) positiveCorrelation path(DOID:"frontotemporal dementia") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) positiveCorrelation path(DOID:"Niemann-Pick disease") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) increases p(CONSO:"Tau aggregates") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) positiveCorrelation p(CONSO:"Tau aggregates") |
| pubmed:27041503 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) decreases bp(GO:"regulation of synaptic plasticity") |
| pubmed:27041503 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) decreases p(HGNC:WWC1) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281)) positiveCorrelation path(DOID:"Alzheimer's disease") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281)) negativeCorrelation bp(GO:memory) |
| pubmed:27041503 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281)) decreases bp(GO:memory) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281)) negativeCorrelation bp(GO:"long-term synaptic potentiation") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281), loc(CONSO:"microtubule-binding region")) increases bp(GO:"microtubule severing") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281), loc(CONSO:"microtubule-binding region")) increases p(CONSO:"Tau fibrils") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281)) decreases deg(p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281))) |
| pubmed:27041503 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281)) decreases bp(GO:"regulation of synaptic plasticity") |
| pubmed:27041503 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281)) decreases p(HGNC:WWC1) |
| pubmed:29661268 | p(HGNC:MAPT, var("p.Lys280Gln")) association p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:29661268 | p(HGNC:MAPT, var("p.Lys280Gln")) decreases bp(GO:"microtubule bundle formation") |
| pubmed:29661268 | p(HGNC:MAPT, var("p.Lys280Gln")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:29661268 | p(HGNC:MAPT, var("p.Lys280Gln")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212), pmod(go:0006468 ! "protein phosphorylation", Thr, 214)) |
| pubmed:29661268 | p(HGNC:MAPT, var("p.Lys280Gln")) increases p(HGNC:MAPT) |
| pubmed:28287136 | p(HGNC:MAPT, var("p.Lys280Gln")) increases a(CONSO:"Tau aggregates") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 259), loc(CONSO:"KXGS motif")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser), pmod(go:0006468 ! "protein phosphorylation", Thr), loc(CONSO:"microtubule-binding region")) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 259), loc(CONSO:"KXGS motif")) decreases p(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 259)) increases deg(p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 259))) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 259)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 259)) decreases a(CONSO:"Tau aggregates") |
| pubmed:26192747 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 259)) isA p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:26192747 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 259)) partOf p(CONSO:"microtubule-binding region") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 353), loc(CONSO:"KXGS motif")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser), pmod(go:0006468 ! "protein phosphorylation", Thr), loc(CONSO:"microtubule-binding region")) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 353), loc(CONSO:"KXGS motif")) decreases p(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 353)) increases deg(p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 353))) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 353)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 353)) decreases a(CONSO:"Tau aggregates") |
| pubmed:29661268 | act(p(HGNC:CDK2), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:12428809 | p(HGNC:CDK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 235)) |
| pubmed:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 235)) |
| pubmed:22072628 | act(p(HGNC:CDK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 235)) |
| pubmed:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:22072628 | p(HGNC:CDK2) increases p(CONSO:"Tau epitope, AT180") |
| pubmed:22072628 | act(p(HGNC:CDK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) |
| pubmed:22072628 | act(p(HGNC:CDK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 217)) |
| pubmed:18305152 | p(HGNC:CDK2) association act(p(HGNC:RB1)) |
| pubmed:18305152 | p(HGNC:CDK2) regulates bp(GO:"cell cycle") |
| pubmed:29661268 | act(p(HGNC:MARK1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:12428809 | p(HGNC:MARK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26631930 | p(HGNC:MARK1) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26631930 | p(HGNC:MARK1) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:21311567 | act(p(HGNC:MARK1)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:22952452 | act(p(HGNC:MARK1), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:23001711 | p(HGNC:MARK1) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:17493042 | p(HGNC:MARK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser)) |
| pubmed:21311567 | act(p(HGNC:MARK1)) decreases bp(GO:"microtubule polymerization") |
| pubmed:29661268 | act(p(MESH:"Cyclic AMP-Dependent Protein Kinases"), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29661268 | act(p(MESH:"Protein Kinase C"), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29661268 | act(p(HGNC:FYN), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19293145 | p(HGNC:FYN) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:18680553 | p(HGNC:FYN) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19293145 | p(HGNC:FYN) increases bp(GO:cognition) |
| pubmed:19293145 | p(HGNC:FYN) increases act(p(FPLX:PI3K)) |
| pubmed:19293145 | p(HGNC:FYN) increases p(HGNC:AGAP2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19293145 | p(HGNC:FYN) decreases bp(GO:"apoptotic process") |
| pubmed:19293145 | p(HGNC:FYN) association bp(MESH:Neuroprotection) |
| pubmed:19293145 | p(HGNC:FYN) increases bp(MESH:Neuroprotection) |
| pubmed:19293145 | p(HGNC:FYN) association act(a(CHEBI:amyloid-beta)) |
| pubmed:18680553 | p(HGNC:FYN) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) |
| pubmed:19293145 | p(HGNC:FYN) increases complex(p(HGNC:FYN), p(HGNC:PTK2)) |
| pubmed:19293145 | p(HGNC:FYN) increases p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19293145 | p(HGNC:FYN) increases p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24760868 | p(HGNC:FYN) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pubmed:30640040 | p(HGNC:FYN) association a(PUBCHEM:4878) |
| pubmed:29191965 | p(HGNC:FYN) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr)) |
| pubmed:26751493 | p(HGNC:FYN) association p(CONSO:"projection domain") |
| pubmed:26631930 | p(HGNC:FYN) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) |
| pubmed:17493042 | p(HGNC:FYN) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) |
| pubmed:26631930 | p(HGNC:FYN) increases p(HGNC:GRIN2B, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:18680553 | p(HGNC:FYN) association p(RGD:Mapt, frag("223_226")) |
| pubmed:26751493 | p(HGNC:FYN) association bp(GO:myelination) |
| pubmed:29661268 | act(p(HGNC:ABL1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30116051 | p(HGNC:ABL1) decreases bp(GO:macroautophagy) |
| pubmed:29191965 | p(HGNC:ABL1) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr)) |
| pubmed:26631930 | p(HGNC:ABL1) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 394)) |
| pubmed:17493042 | p(HGNC:ABL1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 394)) |
| pubmed:23687953 | act(p(HGNC:ABL1), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 363)) |
| pubmed:29661268 | p(CONSO:"Tau epitope, AT8") increases complex(a(CONSO:pretangles), p(CONSO:"Tau epitope, AT8")) |
| pubmed:25478017 | p(CONSO:"Tau epitope, AT8") decreases a(CONSO:"Tau fibrils") |
| pubmed:28784767 | p(CONSO:"Tau epitope, AT8") equivalentTo p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205), pmod(go:0006468 ! "protein phosphorylation", Thr, 208)) |
| pubmed:28784767 | p(CONSO:"Tau epitope, AT8") increases a(CONSO:"Tau aggregates") |
| pubmed:21734277 | p(CONSO:"Tau epitope, AT8") decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:21734277 | p(CONSO:"Tau epitope, AT8") causesNoChange bp(GO:"retrograde axonal protein transport") |
| pubmed:21734277 | p(CONSO:"Tau epitope, AT8") causesNoChange p(CONSO:"phosphatase-activating domain") |
| pubmed:23088643 | p(CONSO:"Tau epitope, AT8") association a(GO:"neurofibrillary tangle") |
| pubmed:23088643 | p(CONSO:"Tau epitope, AT8") association a(MESH:"Neuropil Threads") |
| pubmed:23088643 | p(CONSO:"Tau epitope, AT8") association path(MESH:"Plaque, Amyloid") |
| pubmed:28784767 | p(CONSO:"Tau epitope, AT8") increases p(CONSO:"Tau aggregates") |
| pubmed:27087442 | p(CONSO:"Tau epitope, AT8") positiveCorrelation p(CONSO:"CDK5R1 p25") |
| pubmed:22253473 | p(CONSO:"Tau epitope, AT8") positiveCorrelation a(MESH:Neuropil) |
| pubmed:20869593 | p(CONSO:"Tau epitope, AT8") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:20869593 | p(CONSO:"Tau epitope, AT8") negativeCorrelation act(p(HGNC:SIRT1)) |
| pubmed:27574109 | a(CONSO:pretangles) association a(CONSO:"Tau oligomers") |
| pubmed:27574109 | a(CONSO:pretangles) association p(CONSO:"phosphatase-activating domain") |
| pubmed:27574109 | a(CONSO:pretangles) association p(HGNC:MAPT) |
| pubmed:23407988 | a(CONSO:pretangles) increases complex(GO:"dendritic tree") |
| pubmed:23088643 | a(CONSO:pretangles) association p(HGNC:TTBK1) |
| pubmed:23088643 | a(CONSO:pretangles) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:23088643 | a(CONSO:pretangles) isA a(GO:"neurofibrillary tangle") |
| pubmed:29661268 | p(CONSO:"Tau epitope, AT100") increases complex(a(CONSO:"Tau fibrils"), p(CONSO:"Tau epitope, AT100")) |
| pubmed:4255369 | a(CONSO:"Tau fibrils") positiveCorrelation bp(GO:aging) |
| pubmed:28528849 | a(CONSO:"Tau fibrils") causesNoChange a(MESH:"Dendritic Spines") |
| pubmed:30108137 | a(CONSO:"Tau fibrils", loc(GO:lysosome)) increases deg(p(MGI:Tfeb)) |
| pubmed:29988016 | a(CONSO:"Tau fibrils") increases a(CONSO:"Tau aggregates") |
| pubmed:29686391 | a(CONSO:"Tau fibrils") causesNoChange tloc(a(CONSO:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:28420982 | a(CONSO:"Tau fibrils") increases a(GO:"neurofibrillary tangle") |
| pubmed:24869773 | a(CONSO:"Tau fibrils") association p(HGNC:MAPT) |
| pubmed:23088643 | a(CONSO:"Tau fibrils") association p(HGNC:TTBK1) |
| pubmed:23088643 | a(CONSO:"Tau fibrils") increases a(CONSO:pretangles) |
| pubmed:29661268 | a(CHEBI:"lithium atom") decreases p(HGNC:GSK3B) |
| pubmed:29661268 | a(CHEBI:"lithium atom") decreases path(DOID:"bipolar disorder") |
| pubmed:29661268 | a(CHEBI:"lithium atom") positiveCorrelation bp(GO:cognition) |
| pubmed:16340157 | a(CHEBI:"lithium atom") increases p(HGNC:HSPA5) |
| pubmed:23528736 | a(CHEBI:"lithium atom") increases bp(GO:autophagy) |
| pubmed:23528736 | a(CHEBI:"lithium atom") decreases p(HGNC:MAPT) |
| pubmed:23528736 | a(CHEBI:"lithium atom") decreases path(HP:"Neurofibrillary tangles") |
| pubmed:27190210 | path(DOID:"bipolar disorder") association g(HGNC:CHRNA7) |
| pubmed:26979166 | path(DOID:"bipolar disorder") increases path(MESH:Depression) |
| pubmed:26979166 | path(DOID:"bipolar disorder") increases path(NCIT:C78349) |
| pubmed:26979166 | path(DOID:"bipolar disorder") positiveCorrelation path(DOID:"diabetes mellitus") |
| pubmed:26979166 | path(DOID:"bipolar disorder") positiveCorrelation path(DOID:obesity) |
| pubmed:26979166 | path(DOID:"bipolar disorder") positiveCorrelation path(DOID:"cardiovascular system disease") |
| pubmed:26979166 | path(DOID:"bipolar disorder") positiveCorrelation path(MESH:Smoking) |
| pubmed:26979166 | path(DOID:"bipolar disorder") positiveCorrelation path(MESH:Alcoholism) |
| pubmed:26979166 | path(DOID:"bipolar disorder") increases bp(GO:"microglial cell activation") |
| pubmed:26979166 | path(DOID:"bipolar disorder") association p(HGNC:CHRFAM7A, var("?")) |
| pubmed:29661268 | act(p(HGNCGENEFAMILY:"Protein phosphatases")) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:29661268 | p(HGNC:PPA1) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29661268 | p(HGNC:PPP2CA) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | p(HGNC:PPP2CA) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29191965 | p(HGNC:PPP2CA) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26631930 | p(HGNC:PPP2CA) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26631930 | p(HGNC:PPP2CA) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29661268 | act(p(HGNC:PPP2CA)) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:29661268 | act(p(HGNC:PPP2CA)) negativeCorrelation a(CHEBI:sirolimus) |
| pubmed:23454242 | p(HGNC:PPP2CA) association a(MESH:"Cell Membrane") |
| pubmed:24653673 | p(HGNC:PPP2CA) association act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:10464280 | p(HGNC:PPP2CA) isA complex(GO:"protein phosphatase type 2A complex") |
| pubmed:19277525 | p(HGNC:PPP2CA) association complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) |
| pubmed:19277525 | p(HGNC:PPP2CA) association p(HGNC:PPP2R1A) |
| pubmed:19277525 | p(HGNC:PPP2CA) causesNoChange complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pubmed:24653673 | p(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26631930 | act(p(HGNC:PPP2CA)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | deg(p(HGNC:PPP2CA)) positiveCorrelation p(HGNC:IGBP1, frag("?")) |
| pubmed:29626319 | p(HGNC:PPP2CA) increases bp(GO:autophagy) |
| pubmed:10464280 | p(HGNC:PPP2CA) association complex(GO:microtubule) |
| pubmed:10464280 | p(HGNC:PPP2CA) increases complex(complex(GO:microtubule), p(HGNC:PPP2CA)) |
| pubmed:29228318 | act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:19401603 | act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:19401603 | act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) |
| pubmed:29661268 | p(HGNC:PPP3CA) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27299292 | act(p(HGNC:PPP3CA), ma(go:0016791 ! "phosphatase activity")) decreases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27299292 | act(p(HGNC:PPP3CA), ma(go:0016791 ! "phosphatase activity")) increases act(p(HGNC:TFEB)) |
| pubmed:27299292 | act(p(HGNC:PPP3CA), ma(go:0016791 ! "phosphatase activity")) association bp(GO:"response to endoplasmic reticulum stress") |
| pubmed:27299292 | p(HGNC:PPP3CA) association p(HGNC:EIF2AK3) |
| pubmed:29661268 | p(HGNCGENEFAMILY:"Protein phosphatases, Mg2+/Mn2+ dependent") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29661268 | p(MESH:Calcineurin) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29661268 | p(HGNC:PPP5C) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21882945 | p(HGNC:PPP5C) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29311797 | act(p(HGNC:PPP5C)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26631930 | p(HGNC:PPP5C) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21882945 | p(HGNC:PPP5C) increases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:29661268 | a(CHEBI:"okadaic acid") decreases act(p(HGNC:PPA1)) |
| pubmed:29661268 | a(CHEBI:"okadaic acid") decreases act(p(HGNC:PPP2CA)) |
| pubmed:19277525 | a(CHEBI:"okadaic acid") decreases act(p(HGNC:PPP2CA)) |
| pubmed:29661268 | a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:22299660 | a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:23454242 | a(CHEBI:"okadaic acid") increases path(MESH:Neoplasms) |
| pubmed:19277525 | a(CHEBI:"okadaic acid") increases path(MESH:Neoplasms) |
| pubmed:23454242 | a(CHEBI:"okadaic acid") decreases act(p(FPLX:PPP2C)) |
| pubmed:19277525 | a(CHEBI:"okadaic acid") decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | a(CHEBI:"okadaic acid") decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | a(CHEBI:"okadaic acid") decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:19277525 | a(CHEBI:"okadaic acid") decreases act(p(HGNC:PPME1)) |
| pubmed:24653673 | a(CHEBI:"okadaic acid") increases complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CA)) |
| pubmed:24653673 | a(CHEBI:"okadaic acid") increases complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CB)) |
| pubmed:24653673 | a(CHEBI:"okadaic acid") decreases bp(GO:cognition) |
| pubmed:24653673 | a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | a(CHEBI:"okadaic acid") increases bp(CONSO:amyloidogenesis) |
| pubmed:24653673 | a(CHEBI:"okadaic acid") decreases a(GO:synapse) |
| pubmed:24653673 | a(CHEBI:"okadaic acid") increases path(CONSO:Neurodegeneration) |
| pubmed:22299660 | a(CHEBI:"okadaic acid") decreases act(p(FPLX:PPP2)) |
| pubmed:22299660 | a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 198)) |
| pubmed:22299660 | a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:22299660 | a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:22299660 | a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:22299660 | a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:22299660 | a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:22299660 | a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:22299660 | a(CHEBI:"okadaic acid") decreases bp(GO:learning) |
| pubmed:22299660 | a(CHEBI:"okadaic acid") decreases bp(GO:memory) |
| pubmed:16464864 | a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(go:0016925 ! "protein sumoylation", Lys, 340)) |
| pubmed:29661268 | p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation bp(GO:autophagy) |
| pubmed:30061532 | p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation")) increases bp(GO:autophagy) |
| pubmed:29661268 | p(HGNC:ULK1) positiveCorrelation bp(GO:autophagy) |
| pubmed:23528736 | p(HGNC:ULK1) increases bp(GO:autophagy) |
| pubmed:30116051 | p(HGNC:ULK1) increases bp(GO:macroautophagy) |
| pubmed:30116051 | act(p(HGNC:ULK1)) increases bp(GO:"autophagosome assembly") |
| pubmed:30116051 | act(p(HGNC:ULK1)) increases p(HGNC:AMBRA1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30116051 | act(p(HGNC:ULK1)) increases p(HGNC:BECN1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29661268 | a(CHEBI:nutrient) increases act(p(HGNC:MTOR)) |
| pubmed:29661268 | act(p(HGNC:MTOR)) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:30061532 | act(p(HGNC:MTOR)) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:29661268 | act(p(HGNC:MTOR)) decreases p(CONSO:"Tau aggregates") |
| pubmed:30061532 | act(p(HGNC:MTOR)) regulates deg(p(MESH:Proteins, pmod(CONSO:misfolded))) |
| pubmed:30061532 | act(p(HGNC:MTOR)) negativeCorrelation bp(GO:autophagy) |
| pubmed:30061532 | act(p(HGNC:MTOR)) decreases bp(GO:autophagy) |
| pubmed:30061532 | p(HGNC:MTOR) decreases bp(GO:autophagy) |
| pubmed:30106381 | p(HGNC:MTOR) association bp(GO:autophagy) |
| pubmed:30027901 | p(HGNC:MTOR) decreases bp(GO:autophagy) |
| pubmed:21722302 | p(HGNC:MTOR) regulates bp(GO:autophagy) |
| pubmed:21722302 | act(p(HGNC:MTOR)) decreases bp(GO:autophagy) |
| pubmed:21722302 | p(HGNC:MTOR) decreases bp(GO:autophagy) |
| pubmed:26968346 | act(p(HGNC:MTOR)) positiveCorrelation bp(GO:autophagy) |
| pubmed:29758300 | p(HGNC:MTOR) negativeCorrelation bp(GO:autophagy) |
| pubmed:22908190 | p(HGNC:MTOR) regulates bp(GO:autophagy) |
| pubmed:18930136 | p(HGNC:MTOR) negativeCorrelation bp(GO:autophagy) |
| pubmed:30061532 | act(p(HGNC:MTOR)) positiveCorrelation path(MESH:"Neurodegenerative Diseases") |
| pubmed:30061532 | act(p(HGNC:MTOR)) increases a(CHEBI:amyloid-beta) |
| pubmed:30061532 | act(p(HGNC:MTOR)) increases path(MESH:"Alzheimer Disease") |
| pubmed:30061532 | act(p(HGNC:MTOR)) increases a(CONSO:"Tau aggregates") |
| pubmed:30061532 | act(p(HGNC:MTOR)) decreases bp(GO:cognition) |
| pubmed:30061532 | act(p(HGNC:MTOR)) association act(g(HGNC:DISC1)) |
| pubmed:30061532 | act(p(HGNC:MTOR)) association act(g(HGNC:NRG1)) |
| pubmed:30061532 | act(p(HGNC:MTOR)) association act(g(HGNC:DPYSL2)) |
| pubmed:30061532 | act(p(HGNC:MTOR)) increases act(a(CHEBI:methamphetamine)) |
| pubmed:30061532 | act(p(HGNC:MTOR)) association r(HGNC:MAP6) |
| pubmed:30061532 | act(p(HGNC:MTOR)) association p(HGNC:MAP6) |
| pubmed:30061532 | act(p(HGNC:MTOR)) association p(HGNC:NRG1) |
| pubmed:30061532 | act(p(HGNC:MTOR)) association path(MESH:Schizophrenia) |
| pubmed:30061532 | act(p(HGNC:MTOR)) negativeCorrelation path(MESH:Schizophrenia) |
| pubmed:30106381 | p(HGNC:MTOR) association bp(GO:translation) |
| pubmed:30106381 | p(HGNC:MTOR) association a(GO:"actin cytoskeleton") |
| pubmed:21722302 | p(HGNC:MTOR) negativeCorrelation p(HGNC:PRKAA1) |
| pubmed:26968346 | p(HGNC:MTOR) decreases p(HGNC:TFEB) |
| pubmed:29758300 | p(HGNC:MTOR) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30985105 | act(p(HGNC:MTOR)) increases p(HGNC:SNCA) |
| pubmed:29661268 | a(CHEBI:"carbon atom") increases act(p(HGNC:MTOR)) |
| pubmed:29661268 | complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser)), p(HGNC:STUB1)) increases p(HGNC:MAPT) |
| pubmed:29661268 | complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser)), p(HGNC:STUB1)) increases p(CONSO:"Tau aggregates") |
| pubmed:29661268 | complex(p(CONSO:"paired helical filaments"), p(HGNC:MAPT)) increases complex(p(CONSO:"paired helical filaments"), p(HGNC:MAPT), p(MESH:"Proteasome Endopeptidase Complex")) |
| pubmed:29661268 | complex(p(CONSO:"paired helical filaments"), p(HGNC:MAPT), p(MESH:"Proteasome Endopeptidase Complex")) decreases act(p(MESH:"Proteasome Endopeptidase Complex")) |
| pubmed:29661268 | complex(p(CONSO:"paired helical filaments"), p(HGNC:MAPT), p(MESH:"Proteasome Endopeptidase Complex")) decreases deg(p(HGNC:MAPT)) |
| pubmed:29661268 | act(p(MESH:"Proteasome Endopeptidase Complex")) increases deg(p(MESH:Proteins)) |
| pubmed:29661268 | act(p(MESH:"Proteasome Endopeptidase Complex")) increases deg(p(HGNC:MAPT)) |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination", Lys, 254), loc(CONSO:"microtubule-binding region")) decreases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) |
| pubmed:8391280 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination", Lys, 254)) positiveCorrelation a(CONSO:"paired helical filaments") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination", Lys, 311), loc(CONSO:"microtubule-binding region")) decreases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) |
| pubmed:8391280 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination", Lys, 311)) positiveCorrelation a(CONSO:"paired helical filaments") |
| pubmed:29661268 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination", Lys, 353), loc(CONSO:"microtubule-binding region")) decreases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) |
| pubmed:29661268 | p(HGNC:MARCH7) increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:24905733 | p(HGNC:MARCH7) increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:29661268 | composite(p(CONSO:"paired helical filaments"), p(MESH:"Proteasome Endopeptidase Complex")) decreases act(p(MESH:"Proteasome Endopeptidase Complex")) |
| pubmed:30232325 | act(p(HGNC:WNT3A)) increases bp(GO:"canonical Wnt signaling pathway") |
| pubmed:30232325 | act(p(HGNC:WNT3A)) increases bp(GO:"canonical Wnt signaling pathway") |
| pubmed:30232325 | act(p(HGNC:WNT3A)) decreases a(CHEBI:amyloid-beta) |
| pubmed:30232325 | act(p(HGNC:WNT3A)) increases a(CHEBI:amyloid-beta) |
| pubmed:30232325 | bp(GO:"canonical Wnt signaling pathway") association p(HGNC:LRP6) |
| pubmed:30232325 | bp(GO:"canonical Wnt signaling pathway") decreases a(CHEBI:amyloid-beta) |
| pubmed:30232325 | bp(GO:"canonical Wnt signaling pathway") negativeCorrelation bp(GO:"amyloid-beta formation") |
| pubmed:30232325 | act(p(HGNC:WNT5A)) increases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") |
| pubmed:30232325 | bp(GO:"Wnt signaling pathway, planar cell polarity pathway") association p(HGNC:VANGL2) |
| pubmed:30232325 | bp(GO:"Wnt signaling pathway, planar cell polarity pathway") increases a(CHEBI:amyloid-beta) |
| pubmed:30232325 | bp(GO:"Wnt signaling pathway, planar cell polarity pathway") positiveCorrelation bp(GO:"amyloid-beta formation") |
| pubmed:30232325 | p(HGNC:VANGL2) association bp(GO:"Wnt signaling pathway, planar cell polarity pathway") |
| pubmed:30232325 | p(HGNC:LRP6) association bp(GO:"canonical Wnt signaling pathway") |
| pubmed:30232325 | composite(p(HGNC:APP), p(HGNC:LRP6)) increases bp(GO:"canonical Wnt signaling pathway") |
| pubmed:30232325 | composite(p(HGNC:APP), p(HGNC:LRP6)) decreases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") |
| pubmed:30232325 | composite(p(HGNC:APP), p(HGNC:LRP6)) decreases a(CHEBI:amyloid-beta) |
| pubmed:30232325 | composite(p(HGNC:APP), p(HGNC:VANGL2)) decreases bp(GO:"canonical Wnt signaling pathway") |
| pubmed:30232325 | composite(p(HGNC:APP), p(HGNC:VANGL2)) increases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") |
| pubmed:30232325 | composite(p(HGNC:APP), p(HGNC:VANGL2)) increases a(CHEBI:amyloid-beta) |
| pubmed:30232325 | p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) decreases bp(GO:"canonical Wnt signaling pathway") |
| pubmed:30232325 | p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) increases bp(GO:"non-canonical Wnt signaling pathway") |
| pubmed:30232325 | p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) increases a(CHEBI:amyloid-beta) |
| pubmed:11230871 | p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) association act(p(HGNC:APP)) |
| pubmed:11230871 | p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) increases path(MESH:"Plaque, Amyloid") |
| pubmed:11230871 | p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) negativeCorrelation p(FPLX:CHRN) |
| pubmed:30232325 | bp(GO:"amyloid-beta formation") negativeCorrelation bp(GO:"canonical Wnt signaling pathway") |
| pubmed:30232325 | bp(GO:"amyloid-beta formation") positiveCorrelation bp(GO:"Wnt signaling pathway, planar cell polarity pathway") |
| pubmed:27209302 | bp(GO:"amyloid-beta formation") increases p(CONSO:"amyloid-beta fibrils", loc(MESH:Lysosomes)) |
| pubmed:27209302 | bp(GO:"amyloid-beta formation") increases p(CONSO:"amyloid-beta fibrils", loc(GO:cytoplasm)) |
| pubmed:30232325 | act(p(HGNC:DKK1)) decreases act(p(HGNC:WNT3A)) |
| pubmed:30232325 | act(p(HGNC:DKK1)) decreases bp(GO:"canonical Wnt signaling pathway") |
| pubmed:30232325 | act(p(HGNC:DKK1)) increases act(p(HGNC:WNT5A)) |
| pubmed:30232325 | act(p(HGNC:DKK1)) increases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") |
| pubmed:30232325 | p(HGNC:DKK1) increases path(CONSO:CONSO00061) |
| pubmed:30232325 | p(HGNC:DKK1) decreases a(MESH:"Dendritic Spines") |
| pubmed:30232325 | p(HGNC:DKK1) decreases a(MESH:"Dendritic Spines") |
| pubmed:30232325 | p(HGNC:DKK1) increases a(CHEBI:amyloid-beta) |
| pubmed:30232325 | p(HGNC:DKK1) increases bp(GO:"amyloid-beta formation") |
| pubmed:18494933 | p(HGNC:DKK1) increases act(p(HGNC:GSK3B)) |
| pubmed:18494933 | p(HGNC:DKK1) increases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:18494933 | p(HGNC:DKK1) decreases bp(GO:"Wnt signaling pathway") |
| pubmed:18494933 | p(HGNC:DKK1) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:18494933 | p(HGNC:DKK1) increases deg(p(MESH:"beta Catenin")) |
| pubmed:18494933 | p(HGNC:DKK1) positiveCorrelation deg(p(HGNC:CTNNB1)) |
| pubmed:30232325 | composite(p(HGNC:APP), p(HGNC:DKK1)) decreases a(MESH:"Dendritic Spines") |
| pubmed:24760868 | a(MESH:"Dendritic Spines") increases complex(a(MESH:"Dendritic Spines"), p(HGNC:MAPT)) |
| pubmed:27796283 | a(MESH:"Dendritic Spines") positiveCorrelation bp(GO:"dendritic spine development") |
| pubmed:27796283 | a(MESH:"Dendritic Spines") negativeCorrelation act(p(HGNC:RHOA)) |
| pubmed:27796283 | a(MESH:"Dendritic Spines") positiveCorrelation p(HGNC:CAMKV) |
| pubmed:30232325 | a(CHEBI:"fasudil hydrochloride") decreases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") |
| pubmed:30232325 | a(CHEBI:"fasudil hydrochloride") decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pubmed:30232325 | a(CHEBI:"fasudil hydrochloride") decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pubmed:30232325 | composite(a(CHEBI:"fasudil hydrochloride"), p(HGNC:DKK1)) causesNoChange a(MESH:"Dendritic Spines") |
| pubmed:30232325 | composite(a(CHEBI:"fasudil hydrochloride"), p(HGNC:DKK1)) causesNoChange a(CHEBI:amyloid-beta) |
| pubmed:10656250 | p(HGNC:BACE1, var("p.Asp25Asn")) causesNoChange tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:10656250 | p(HGNC:BACE1, var("p.Asp25Asn")) causesNoChange p(HGNC:APP, frag("672_770")) |
| pubmed:10656250 | p(HGNC:BACE1, var("p.Asp215Asn")) causesNoChange tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:10656250 | p(HGNC:BACE1, var("p.Asp215Asn")) causesNoChange p(HGNC:APP, frag("672_770")) |
| pubmed:10656250 | p(HGNC:CTSD) causesNoChange tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:19926167 | p(HGNC:CTSD) association deg(p(HGNC:APP)) |
| pubmed:19926167 | p(HGNC:CTSD) association p(HGNC:APP, frag("672_713")) |
| pubmed:23516100 | p(HGNC:CTSD) increases p(HGNC:APP, frag("35_*")) |
| pubmed:23516100 | p(HGNC:CTSD) increases p(HGNC:MAPT, frag("1_?")) |
| pubmed:23516100 | act(p(HGNC:CTSD)) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23516100 | act(p(HGNC:CTSD)) increases p(HGNC:APP, frag("?")) |
| pubmed:23516100 | p(HGNC:CTSD) increases p(HGNC:APP, frag("1_35")) |
| pubmed:23516100 | p(HGNC:CTSD) increases p(HGNC:SNCA, frag("1_?")) |
| pubmed:23516100 | p(HGNC:CTSD) decreases p(HGNC:SNCA, loc(GO:lysosome)) |
| pubmed:23516100 | p(HGNC:CTSD) decreases p(CONSO:"alpha-synuclein aggregates") |
| pubmed:26968346 | act(p(HGNC:CTSD)) increases p(HGNC:TFEB) |
| pubmed:18930136 | p(HGNC:CTSD) isA a(GO:autolysosome) |
| pubmed:18930136 | p(HGNC:CTSD) decreases path(CONSO:Neurodegeneration) |
| pubmed:18930136 | p(HGNC:CTSD) negativeCorrelation a(GO:lysosome) |
| pubmed:18930136 | p(HGNC:CTSD) negativeCorrelation a(GO:autophagosome) |
| pubmed:24027553 | act(p(HGNC:CTSD)) increases p(HGNC:MAPT, frag("?", "29kD")) |
| pubmed:24027553 | act(p(HGNC:CTSD)) increases deg(p(HGNC:MAPT)) |
| pubmed:24027553 | act(p(HGNC:CTSD)) increases deg(p(HGNC:MAPT)) |
| pubmed:23528736 | p(HGNC:CTSD) increases deg(p(HGNC:MAPT)) |
| pubmed:29626319 | p(HGNC:CTSD) increases deg(p(HGNC:MAPT)) |
| pubmed:24027553 | act(p(HGNC:CTSD)) increases p(HGNC:MAPT, frag("?", "29kD"), pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24027553 | act(p(HGNC:CTSD)) increases path(MESH:Neuroprotection) |
| pubmed:24027553 | act(p(HGNC:CTSD)) decreases path(CONSO:neurotoxicity) |
| pubmed:10656250 | p(CONSO:APP751) association p(HGNC:BACE1) |
| pubmed:22791904 | a(PUBCHEM:11249342) increases path(MESH:Nausea) |
| pubmed:22791904 | a(PUBCHEM:11249342) causesNoChange path(MESH:Nausea) |
| pubmed:22791904 | a(PUBCHEM:11249342) increases path(MESH:Vomiting) |
| pubmed:22791904 | a(PUBCHEM:11249342) causesNoChange path(MESH:Vomiting) |
| pubmed:22791904 | a(PUBCHEM:11249342) decreases p(CONSO:sAPP-alpha) |
| pubmed:22791904 | a(PUBCHEM:11249342) decreases p(CONSO:sAPP-beta) |
| pubmed:22791904 | a(PUBCHEM:11249342) decreases p(HGNC:MAPT) |
| pubmed:22791904 | a(PUBCHEM:11249342) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22791904 | a(PUBCHEM:11249342) decreases p(HGNC:C3) |
| pubmed:22791904 | a(PUBCHEM:11249342) decreases p(HGNC:CCL2) |
| pubmed:22791904 | a(PUBCHEM:11249342) decreases p(HGNC:CHI3L1) |
| pubmed:22791904 | a(PUBCHEM:11249342) causesNoChange p(HGNC:CFH) |
| pubmed:30444369 | a(CHEBI:tacrine) increases bp(GO:cognition) |
| pubmed:30444369 | a(CHEBI:tacrine) decreases act(p(FPLX:Cholinesterase)) |
| pubmed:19293145 | a(CHEBI:tacrine) increases p(HGNC:BCL2) |
| pubmed:19293145 | act(a(CHEBI:tacrine)) negativeCorrelation g(HGNC:APOE) |
| pubmed:24511233 | a(CHEBI:tacrine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") |
| pubmed:11230871 | a(CHEBI:tacrine) decreases act(p(HGNC:ACHE)) |
| pubmed:11230871 | a(CHEBI:tacrine) increases act(p(HGNC:ACHE)) |
| pubmed:11230871 | a(CHEBI:tacrine) increases act(p(FPLX:CHRN)) |
| pubmed:11230871 | a(CHEBI:tacrine) increases p(FPLX:CHRN) |
| pubmed:11230871 | a(CHEBI:tacrine) increases p(FPLX:CHRN) |
| pubmed:30444369 | a(CHEBI:donepezil) increases bp(GO:cognition) |
| pubmed:26813123 | a(CHEBI:donepezil) increases bp(GO:cognition) |
| pubmed:30444369 | a(CHEBI:donepezil) decreases act(p(FPLX:Cholinesterase)) |
| pubmed:19126755 | a(CHEBI:donepezil) decreases p(HGNC:ACHE) |
| pubmed:11230871 | a(CHEBI:donepezil) decreases act(p(HGNC:ACHE)) |
| pubmed:19293145 | a(CHEBI:donepezil) isA a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") |
| pubmed:19293145 | a(CHEBI:donepezil) decreases path(MESH:"Alzheimer Disease") |
| pubmed:19293145 | a(CHEBI:donepezil) decreases path(CONSO:neurotoxicity) |
| pubmed:19293145 | a(CHEBI:donepezil) decreases path(CONSO:neurotoxicity) |
| pubmed:19293145 | a(CHEBI:donepezil) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19293145 | a(CHEBI:donepezil) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19293145 | a(CHEBI:donepezil) increases p(HGNC:CHRNA4) |
| pubmed:19293145 | a(CHEBI:donepezil) increases p(HGNC:CHRNA7) |
| pubmed:19293145 | a(CHEBI:donepezil) increases bp(MESH:Neuroprotection) |
| pubmed:19293145 | a(CHEBI:donepezil) increases p(HGNC:BCL2) |
| pubmed:24511233 | a(CHEBI:donepezil) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") |
| pubmed:18986241 | a(CHEBI:donepezil) increases act(a(MESH:"Frontal Lobe")) |
| pubmed:11230871 | a(CHEBI:donepezil) increases act(p(FPLX:CHRN)) |
| pubmed:11230871 | a(CHEBI:donepezil) increases p(FPLX:CHRN) |
| pubmed:29626319 | a(CHEBI:donepezil) increases p(HGNC:ABCB1) |
| pubmed:29626319 | a(CHEBI:donepezil) increases p(HGNC:LRP1) |
| pubmed:29626319 | a(CHEBI:donepezil) decreases a(CHEBI:amyloid-beta) |
| pubmed:30444369 | a(CHEBI:rivastigmine) increases bp(GO:cognition) |
| pubmed:30444369 | a(CHEBI:rivastigmine) decreases act(p(FPLX:Cholinesterase)) |
| pubmed:19126755 | a(CHEBI:rivastigmine) decreases p(HGNC:ACHE) |
| pubmed:11230871 | a(CHEBI:rivastigmine) decreases act(p(HGNC:ACHE)) |
| pubmed:19293145 | a(CHEBI:rivastigmine) isA a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") |
| pubmed:19293145 | a(CHEBI:rivastigmine) decreases path(MESH:"Alzheimer Disease") |
| pubmed:26813123 | a(CHEBI:rivastigmine) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19293145 | a(CHEBI:rivastigmine) decreases path(CONSO:neurotoxicity) |
| pubmed:19293145 | a(CHEBI:rivastigmine) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:24511233 | a(CHEBI:rivastigmine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") |
| pubmed:11230871 | a(CHEBI:rivastigmine) increases act(p(FPLX:CHRN)) |
| pubmed:11230871 | a(CHEBI:rivastigmine) increases p(FPLX:CHRN) |
| pubmed:29687724 | a(CHEBI:rivastigmine) increases bp(GO:"motor behavior") |
| pubmed:29687724 | a(CHEBI:rivastigmine) increases path(MESH:Cognition) |
| pubmed:29626319 | a(CHEBI:rivastigmine) increases p(HGNC:ABCB1) |
| pubmed:29626319 | a(CHEBI:rivastigmine) increases p(HGNC:LRP1) |
| pubmed:29626319 | a(CHEBI:rivastigmine) decreases a(CHEBI:amyloid-beta) |
| pubmed:30444369 | a(CHEBI:memantine) increases bp(GO:cognition) |
| pubmed:30444369 | a(CHEBI:memantine) decreases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pubmed:19293145 | a(CHEBI:memantine) isA a(CHEBI:"NMDA receptor antagonist") |
| pubmed:22530628 | a(CHEBI:memantine) isA a(CHEBI:"NMDA receptor antagonist") |
| pubmed:19293145 | a(CHEBI:memantine) decreases path(MESH:"Alzheimer Disease") |
| pubmed:23722080 | a(CHEBI:memantine) decreases path(MESH:"Alzheimer Disease") |
| pubmed:22530628 | a(CHEBI:memantine) decreases path(DOID:"Alzheimer's disease") |
| pubmed:26813123 | a(CHEBI:memantine) decreases path(CONSO:Excitotoxicity) |
| pubmed:16273023 | a(CHEBI:memantine) decreases complex(a(CHEBI:"calcium(2+)"), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pubmed:16273023 | a(CHEBI:memantine) causesNoChange bp(MESH:D009435) |
| pubmed:23722080 | a(CHEBI:memantine) decreases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23722080 | a(CHEBI:memantine) increases bp(GO:"cellular metabolic process") |
| pubmed:30837838 | a(CHEBI:memantine) decreases a(CHEBI:"D-glutamate(1-)") |
| pubmed:30837838 | a(CHEBI:memantine) decreases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30444369 | g(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") |
| pubmed:29196815 | g(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") |
| pubmed:26195256 | g(HGNC:APP, var("?")) association path(MESH:"Alzheimer Disease") |
| pubmed:30444369 | g(HGNC:APP, var("?")) increases bp(GO:"amyloid-beta formation") |
| pubmed:30116051 | g(HGNC:APP, var("?")) decreases act(a(GO:endosome)) |
| pubmed:30116051 | g(HGNC:APP, var("?")) decreases act(a(GO:lysosome)) |
| pubmed:30116051 | g(HGNC:APP, var("?")) increases p(CONSO:C99) |
| pubmed:30444369 | g(CONSO:"APOE e4") increases path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | g(CONSO:"APOE e4") increases path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | g(CONSO:"APOE e4") association path(MESH:"Alzheimer Disease") |
| pubmed:30116051 | g(CONSO:"APOE e4") increases path(MESH:"Alzheimer Disease") |
| pubmed:26195256 | g(CONSO:"APOE e4") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:30444369 | g(CONSO:"APOE e4") increases bp(GO:"amyloid-beta clearance") |
| pubmed:19293145 | g(CONSO:"APOE e4") decreases act(a(CHEBI:carbachol)) |
| pubmed:29758300 | g(CONSO:"APOE e4") increases bp(GO:"cholesterol metabolic process") |
| pubmed:29758300 | g(CONSO:"APOE e4") regulates deg(a(CHEBI:amyloid-beta)) |
| pubmed:22908190 | g(CONSO:"APOE e4") increases act(a(CHEBI:amyloid-beta)) |
| pubmed:26195256 | g(CONSO:"APOE e4") positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:22908190 | g(CONSO:"APOE e4") regulates bp(GO:"cholesterol transport") |
| pubmed:22908190 | g(CONSO:"APOE e4") positiveCorrelation p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") |
| pubmed:22908190 | g(CONSO:"APOE e4") positiveCorrelation p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") |
| pubmed:22908190 | g(CONSO:"APOE e4") positiveCorrelation p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") |
| pubmed:22908190 | g(CONSO:"APOE e4") positiveCorrelation bp(GO:endocytosis) |
| pubmed:22908190 | g(CONSO:"APOE e4") increases a(GO:endosome) |
| pubmed:22908190 | g(CONSO:"APOE e4") positiveCorrelation tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) |
| pubmed:30116051 | g(CONSO:"APOE e4") increases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:22908190 | g(CONSO:"APOE e4") increases path(CONSO:Neurodegeneration) |
| pubmed:22908190 | g(CONSO:"APOE e4") increases bp(GO:"apoptotic process") |
| pubmed:30116051 | g(CONSO:"APOE e4") increases p(HGNC:LGMN) |
| pubmed:26195256 | g(CONSO:"APOE e4") regulates bp(GO:"establishment of blood-brain barrier") |
| pubmed:26195256 | g(CONSO:"APOE e4") increases act(p(HGNC:PPIA)) |
| pubmed:27087442 | g(CONSO:"APOE e4") increases p(MGI:Cdk5) |
| pubmed:27087442 | g(CONSO:"APOE e4") increases p(CONSO:"CDK5R1 p25") |
| pubmed:27087442 | g(CONSO:"APOE e4") increases p(MGI:Cdk5r1) |
| pubmed:27087442 | g(CONSO:"APOE e4") increases p(MGI:Capn1) |
| pubmed:27087442 | g(CONSO:"APOE e4") increases p(MGI:Capn2) |
| pubmed:27087442 | g(CONSO:"APOE e4") causesNoChange p(MGI:Gsk3b) |
| pubmed:28720530 | g(CONSO:"APOE e4") decreases p(HGNC:PPP2R5E) |
| pubmed:28720530 | g(CONSO:"APOE e4") decreases act(p(FPLX:PPP2)) |
| pubmed:30444369 | g(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer Disease") |
| pubmed:29196815 | g(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer Disease") |
| pubmed:30116051 | g(HGNC:PSEN1, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26195256 | g(HGNC:PSEN1, var("?")) association path(MESH:"Alzheimer Disease") |
| pubmed:30116051 | g(HGNC:PSEN1, var("?")) negativeCorrelation act(complex(GO:"lysosomal proton-transporting V-type ATPase complex")) |
| pubmed:30116051 | g(HGNC:PSEN1, var("?")) negativeCorrelation bp(GO:autophagy) |
| pubmed:30116051 | g(HGNC:PSEN1, var("?")) negativeCorrelation bp(GO:mitophagy) |
| pubmed:30444369 | g(HGNC:PSEN2, var("?")) increases path(MESH:"Alzheimer Disease") |
| pubmed:29196815 | g(HGNC:PSEN2, var("?")) increases path(MESH:"Alzheimer Disease") |
| pubmed:26195256 | g(HGNC:PSEN2, var("?")) association path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") increases act(p(HGNC:RAB5A)) |
| pubmed:22908190 | p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") increases act(p(HGNC:RAB5A)) |
| pubmed:22908190 | p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation g(CONSO:"APOE e4") |
| pubmed:22908190 | p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation g(CONSO:"APOE e4") |
| pubmed:22908190 | p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation g(CONSO:"APOE e4") |
| pubmed:22908190 | p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation a(CHEBI:"low-density lipoprotein cholesterol") |
| pubmed:22908190 | p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation a(CHEBI:"low-density lipoprotein cholesterol") |
| pubmed:22908190 | p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation p(HGNC:APP) |
| pubmed:22908190 | p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation a(CHEBI:cholesterol) |
| pubmed:22908190 | p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation bp(GO:endocytosis) |
| pubmed:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases path(MESH:"Alzheimer Disease") |
| pubmed:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"response to oxidative stress") |
| pubmed:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases a(CHEBI:"reactive oxygen species") |
| pubmed:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases a(CHEBI:"reactive oxygen species") |
| pubmed:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"apoptotic DNA fragmentation") |
| pubmed:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"neuron death") |
| pubmed:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases bp(GO:learning) |
| pubmed:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases act(p(FPLX:COX)) |
| pubmed:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases bp(GO:"regulation of mitochondrial membrane potential") |
| pubmed:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases a(CHEBI:ATP) |
| pubmed:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases tloc(a(PUBCHEM:16057918), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases act(p(HGNC:CASP3)) |
| pubmed:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"apoptotic process") |
| pubmed:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases complex(a(CHEBI:"NAD(+)"), p(HGNC:HSD17B10)) |
| pubmed:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases act(p(HGNC:HSD17B10)) |
| pubmed:30444369 | p(HGNC:HSD17B10) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:30444369 | act(p(HGNC:HSD17B10)) increases rxn(reactants(a(PUBCHEM:440326)), products(a(PUBCHEM:193425))) |
| pubmed:30444369 | act(p(HGNC:HSD17B10)) increases rxn(reactants(a(CHEBI:"NAD(+)"), a(PUBCHEM:9543037)), products(a(CHEBI:"3-oxo-fatty acyl-CoA(4-)"), a(CHEBI:NADH), a(PUBCHEM:1038))) |
| pubmed:30444369 | act(p(HGNC:HSD17B10)) increases rxn(reactants(a(PUBCHEM:15818)), products(a(PUBCHEM:10635))) |
| pubmed:30444369 | act(p(HGNC:HSD17B10)) increases rxn(reactants(a(PUBCHEM:5757)), products(a(PUBCHEM:5870))) |
| pubmed:30444369 | act(p(HGNC:HSD17B10)) association p(HGNCGENEFAMILY:"Gamma-aminobutyric acid type A receptor subunits") |
| pubmed:30116051 | a(CHEBI:"NAD(+)") increases act(p(HGNC:SIRT1)) |
| pubmed:30116051 | a(CHEBI:"NAD(+)") increases act(p(HGNC:SIRT1)) |
| pubmed:30444369 | a(PUBCHEM:5757) decreases a(CONSO:"amyloid-beta aggregates") |
| pubmed:30444369 | a(PUBCHEM:5757) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:30444369 | a(PUBCHEM:5757) decreases act(p(HGNC:GSK3B)) |
| pubmed:30444369 | a(PUBCHEM:5757) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30444369 | a(PUBCHEM:5757) increases p(HGNC:BCL2) |
| pubmed:30444369 | a(PUBCHEM:5757) increases p(HGNC:BCL2L1) |
| pubmed:30444369 | a(PUBCHEM:5757) decreases p(HGNC:BCL2L11) |
| pubmed:30444369 | a(PUBCHEM:5757) increases p(HGNC:SOD2) |
| pubmed:30444369 | a(PUBCHEM:5757) increases p(FPLX:GPX) |
| pubmed:30444369 | p(HGNCGENEFAMILY:"Gamma-aminobutyric acid type A receptor subunits") association act(p(HGNC:HSD17B10)) |
| pubmed:30444369 | act(p(HGNCGENEFAMILY:"Gamma-aminobutyric acid type A receptor subunits")) positiveCorrelation a(PUBCHEM:101790) |
| pubmed:30444369 | act(p(HGNCGENEFAMILY:"Gamma-aminobutyric acid type A receptor subunits")) positiveCorrelation a(PUBCHEM:92786) |
| pubmed:30444369 | a(PUBCHEM:101790) positiveCorrelation act(p(HGNCGENEFAMILY:"Gamma-aminobutyric acid type A receptor subunits")) |
| pubmed:30444369 | a(PUBCHEM:92786) positiveCorrelation act(p(HGNCGENEFAMILY:"Gamma-aminobutyric acid type A receptor subunits")) |
| pubmed:30606258 | p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(HGNC:GSK3B)) |
| pubmed:18494933 | p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(HGNC:GSK3B)) |
| pubmed:30444369 | a(CHEBI:"methylene blue") decreases complex(p(HGNC:APP), p(HGNC:HSD17B10)) |
| pubmed:30444369 | a(CHEBI:"methylene blue") decreases path(CONSO:"mitochondrial dysfunction") |
| pubmed:30444369 | a(CHEBI:"methylene blue") decreases p(HGNC:HSD17B10) |
| pubmed:30444369 | a(CHEBI:"methylene blue") decreases a(CONSO:"amyloid-beta aggregates") |
| pubmed:29758300 | a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(CONSO:misfolding)) |
| pubmed:29758300 | a(CHEBI:"methylene blue") increases bp(GO:macroautophagy) |
| pubmed:30116051 | a(CHEBI:"methylene blue") increases bp(GO:macroautophagy) |
| pubmed:29758300 | a(CHEBI:"methylene blue") increases p(HGNC:BECN1) |
| pubmed:30116051 | a(CHEBI:"methylene blue") increases p(HGNC:BECN1) |
| pubmed:29758300 | a(CHEBI:"methylene blue") increases p(HGNC:MAP1LC3B) |
| pubmed:29758300 | a(CHEBI:"methylene blue") decreases p(HGNC:MAPT) |
| pubmed:30116051 | a(CHEBI:"methylene blue") decreases act(p(HGNC:MAPT)) |
| pubmed:23528736 | a(CHEBI:"methylene blue") decreases p(HGNC:MAPT) |
| pubmed:29758300 | a(CHEBI:"methylene blue") decreases p(HGNC:SQSTM1) |
| pubmed:30116051 | a(CHEBI:"methylene blue") increases p(HGNC:SQSTM1) |
| pubmed:30116051 | a(CHEBI:"methylene blue") decreases a(CONSO:"Tau oligomers") |
| pubmed:30116051 | a(CHEBI:"methylene blue") increases bp(GO:autophagy) |
| pubmed:23528736 | a(CHEBI:"methylene blue") increases bp(GO:autophagy) |
| pubmed:29626319 | a(CHEBI:"methylene blue") increases bp(GO:autophagy) |
| pubmed:30116051 | a(CHEBI:"methylene blue") increases act(p(FPLX:AMPK)) |
| pubmed:30116051 | a(CHEBI:"methylene blue") increases p(HGNC:MAP1LC3A) |
| pubmed:24027553 | a(CHEBI:"methylene blue") increases bp(MESH:Autophagy) |
| pubmed:24027553 | a(CHEBI:"methylene blue") increases bp(MESH:Autophagy) |
| pubmed:22611162 | a(CHEBI:"methylene blue") increases bp(GO:locomotion) |
| pubmed:29191965 | a(CHEBI:"methylene blue") increases bp(GO:locomotion) |
| pubmed:22611162 | a(CHEBI:"methylene blue") decreases a(CONSO:"Tau aggregates") |
| pubmed:23528736 | a(CHEBI:"methylene blue") decreases a(CONSO:"Tau aggregates") |
| pubmed:29191965 | a(CHEBI:"methylene blue") decreases a(CONSO:"Tau aggregates") |
| pubmed:23528736 | a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23528736 | a(CHEBI:"methylene blue") increases bp(GO:cognition) |
| pubmed:21882945 | a(CHEBI:"methylene blue") decreases act(p(INTERPRO:"Heat shock protein 70 family")) |
| pubmed:26751493 | a(CHEBI:"methylene blue") decreases p(CONSO:"Tau aggregates") |
| pubmed:26751493 | a(CHEBI:"methylene blue") increases bp(GO:"protein catabolic process") |
| pubmed:26751493 | a(CHEBI:"methylene blue") association bp(GO:"response to oxidative stress") |
| pubmed:26751493 | a(CHEBI:"methylene blue") decreases act(p(HGNC:CASP1)) |
| pubmed:26751493 | a(CHEBI:"methylene blue") decreases act(p(HGNC:CASP3)) |
| pubmed:26751493 | a(CHEBI:"methylene blue") increases bp(GO:"energy reserve metabolic process") |
| pubmed:26751493 | a(CHEBI:"methylene blue") isA a(CHEBI:antioxidant) |
| pubmed:27708431 | a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:27708431 | a(CHEBI:"methylene blue") decreases act(p(HGNC:MARK4), ma(go:0016301 ! "kinase activity")) |
| pubmed:27708431 | a(CHEBI:"methylene blue") increases deg(p(HGNC:MARK4)) |
| pubmed:27708431 | a(CHEBI:"methylene blue") increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:28287136 | a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30515821 | a(CHEBI:ATP) increases a(CHEBI:"reactive oxygen species") |
| pubmed:25437566 | a(CHEBI:ATP) association act(p(FPLX:HSP90)) |
| pubmed:23746257 | a(CHEBI:ATP) regulates act(p(FPLX:HSP90)) |
| pubmed:25437566 | a(CHEBI:ATP) association act(p(FPLX:HSPA)) |
| pubmed:23746257 | a(CHEBI:ATP) regulates act(p(FPLX:HSPA)) |
| pubmed:25437566 | a(CHEBI:ATP) association act(p(HGNC:HSPD1)) |
| pubmed:25437566 | a(CHEBI:ATP) association act(p(HGNCGENEFAMILY:"AAA ATPases")) |
| pubmed:23746257 | a(CHEBI:ATP) regulates act(p(HGNCGENEFAMILY:Chaperonins)) |
| pubmed:23746257 | a(CHEBI:ATP) causesNoChange act(p(FPLX:HSPB)) |
| pubmed:23746257 | a(CHEBI:ATP) regulates complex(p(HGNC:HSPD1), p(HGNC:HSPE1)) |
| pubmed:24457024 | a(CHEBI:ATP) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) |
| pubmed:24457024 | a(CHEBI:ATP) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(CONSO:"20 S Proteasome")) |
| pubmed:19251756 | a(CHEBI:ATP) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24561250 | a(CHEBI:ATP) increases act(complex(GO:"inflammasome complex")) |
| pubmed:24561250 | a(CHEBI:ATP) increases act(complex(GO:"inflammasome complex")) |
| pubmed:24561250 | a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pubmed:24561250 | a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pubmed:24561250 | a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pubmed:24561250 | a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pubmed:28499950 | act(p(HGNC:CASP3)) directlyIncreases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, frag("152_*")))) |
| pubmed:23516100 | act(p(HGNC:CASP3)) increases complex(p(HGNC:CASP3), p(HGNC:MAPT, frag("1_421"))) |
| pubmed:23516100 | p(HGNC:CASP3) increases p(HGNC:MAPT, frag("1_421")) |
| pubmed:26631930 | p(HGNC:CASP3) increases p(HGNC:MAPT, frag("1_421")) |
| pubmed:23516100 | p(HGNC:CASP3) increases p(HGNC:APP, frag("219_*")) |
| pubmed:23516100 | p(HGNC:CASP3) increases p(HGNC:SNCA, frag("1_122")) |
| pubmed:23516100 | p(HGNC:CASP3) increases p(HGNC:SNCA, frag("1_119")) |
| pubmed:23516100 | p(HGNC:CASP3) increases p(HGNC:SNCA, frag("1_133")) |
| pubmed:23516100 | p(HGNC:CASP3) increases p(HGNC:MAPT, frag("?")) |
| pubmed:23516100 | p(HGNC:CASP3) increases p(HGNC:MAPT, frag("?")) |
| pubmed:23516100 | p(HGNC:CASP3) increases p(HGNC:APP, frag("?")) |
| pubmed:23516100 | p(HGNC:CASP3) increases p(HGNC:MAPT, frag("421_*"), var("?")) |
| pubmed:23516100 | p(HGNC:CASP3) increases p(HGNC:HTT, frag("1_513")) |
| pubmed:23516100 | p(HGNC:CASP3) increases p(HGNC:HTT, frag("1_548")) |
| pubmed:23516100 | p(HGNC:CASP3) increases p(HGNC:HTT, frag("1_552")) |
| pubmed:23516100 | act(p(HGNC:CASP3)) increases p(HGNC:TARDBP, frag("?")) |
| pubmed:21722302 | act(p(HGNC:CASP3)) increases bp(MESH:"Cell Death") |
| pubmed:29758300 | p(HGNC:CASP3) increases p(HGNC:BECN1, frag("?")) |
| pubmed:30116051 | act(p(HGNC:CASP3)) increases p(HGNC:BECN1, frag("?")) |
| pubmed:24027553 | act(p(HGNC:CASP3)) increases p(HGNC:MAPT, frag("?_*")) |
| pubmed:24027553 | act(p(HGNC:CASP3)) increases deg(p(HGNC:MAPT)) |
| pubmed:24027553 | act(p(HGNC:CASP3)) increases p(CONSO:"Tau C3") |
| pubmed:24027553 | act(p(HGNC:CASP3)) increases p(CONSO:"Tau C3") |
| pubmed:24027553 | act(p(HGNC:CASP3)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26631930 | p(HGNC:CASP3) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, frag("1_421")), p(HGNC:MAPT, frag("421_*")))) |
| pubmed:29238289 | act(p(HGNC:CASP3)) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, frag("1_421")), p(HGNC:MAPT, frag("421_*")))) |
| pubmed:27068745 | p(HGNC:CASP3) association act(p(FPLX:JNK)) |
| pubmed:27068745 | p(HGNC:CASP3) association act(p(HGNC:MAP3K5)) |
| pubmed:27068745 | p(HGNC:CASP3) increases bp(GO:"neuron apoptotic process") |
| pubmed:30837838 | p(HGNC:CASP3) increases p(HGNC:TARDBP, frag("?"), var("p.Asp169Gly")) |
| pubmed:30837838 | p(HGNC:CASP3) decreases p(HGNC:TARDBP, frag("?"), var("p.Ala90Val")) |
| pubmed:27314526 | act(p(HGNC:CASP3)) increases bp(GO:"neuron death") |
| pubmed:30444369 | p(HGNC:BCL2L11) increases bp(GO:"apoptotic process") |
| pubmed:23528736 | p(HGNC:BCL2L11) decreases bp(GO:autophagy) |
| pubmed:30444369 | act(p(HGNC:PRDX2)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:30444369 | p(HGNC:PRDX2) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:30444369 | p(HGNC:PRDX2, pmod(go:0006468 ! "protein phosphorylation", Thr, 89)) decreases act(p(HGNC:PRDX2)) |
| pubmed:30444369 | p(HGNC:SH3GL2) increases bp(GO:"synaptic vesicle endocytosis") |
| pubmed:30444369 | p(HGNC:SH3GL2) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:30444369 | p(HGNC:SH3GL2) increases act(p(HGNC:MAP3K1)) |
| pubmed:30444369 | p(HGNC:SH3GL2) association bp(GO:"neuron projection development") |
| pubmed:30444369 | p(HGNC:SH3GL2) association bp(GO:"regulation of synaptic plasticity") |
| pubmed:30444369 | p(HGNC:SH3GL2) association bp(GO:"neuron death") |
| pubmed:30444369 | act(p(HGNC:MAP3K1)) increases bp(GO:"JNK cascade") |
| pubmed:30444369 | bp(GO:"neuron projection development") association p(HGNC:SH3GL2) |
| pubmed:18986241 | bp(GO:"neuron projection development") association act(p(HGNCGENEFAMILY:"Mitogen-activated protein kinases")) |
| pubmed:20133804 | bp(GO:"neuron projection development") negativeCorrelation p(RGD:Fkbp4) |
| pubmed:30444369 | a(CONSO:AG18051) decreases act(p(HGNC:HSD17B10)) |
| pubmed:30444369 | a(CONSO:AG18051) decreases act(a(CONSO:"amyloid-beta aggregates")) |
| pubmed:30444369 | a(CONSO:RM-532-46) decreases act(p(HGNC:HSD17B10)) |
| pubmed:30444369 | a(PUBCHEM:33334) decreases complex(p(HGNC:APP), p(HGNC:HSD17B10)) |
| pubmed:30444369 | a(PUBCHEM:33334) decreases act(p(HGNC:CSNK1A1)) |
| pubmed:30444369 | composite(a(PUBCHEM:208907), a(PUBCHEM:33334)) decreases act(p(HGNC:MAOA)) |
| pubmed:29196815 | path(MESH:Obesity) increases path(MESH:"Alzheimer Disease") |
| pubmed:29196815 | path(MESH:"Diabetes Mellitus") increases path(MESH:"Alzheimer Disease") |
| pubmed:26195256 | path(MESH:"Diabetes Mellitus") increases path(MESH:"Alzheimer Disease") |
| pubmed:30740335 | path(MESH:"Diabetes Mellitus") association path(MESH:"Endoplasmic Reticulum Stress") |
| pubmed:29626319 | path(MESH:"Diabetes Mellitus") negativeCorrelation p(HGNC:IDE) |
| pubmed:29626319 | path(MESH:"Diabetes Mellitus") positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:29196815 | g(CONSO:CONSO00030) increases path(MESH:"Alzheimer Disease") |
| pubmed:21718217 | g(CONSO:CONSO00030) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21718217 | g(CONSO:CONSO00030) association path(MESH:"Alzheimer Disease") |
| pubmed:21718217 | g(CONSO:CONSO00030) increases a(CONSO:CONSO00018) |
| pubmed:26837465 | complex(GO:"neurofibrillary tangle") association p(HGNC:ESR1) |
| pubmed:26837465 | complex(GO:"neurofibrillary tangle") association p(HGNC:ESR1) |
| pubmed:24368848 | complex(GO:"neurofibrillary tangle") causesNoChange act(a(MESH:Neurons)) |
| pubmed:23407988 | complex(GO:"neurofibrillary tangle") decreases complex(GO:"dendritic tree") |
| pubmed:10391244 | complex(GO:"neurofibrillary tangle") association complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)), p(HGNC:PIN1, frag("5_39"))) |
| pubmed:10391244 | complex(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:CDK1) |
| pubmed:12714745 | complex(GO:"neurofibrillary tangle") positiveCorrelation g(DBSNP:rs104893877) |
| pubmed:29196815 | a(CONSO:CONSO00074) increases bp(GO:"neuron death") |
| pubmed:29196815 | a(CONSO:CONSO00074) increases bp(GO:"neuron death") |
| pubmed:29196815 | a(CONSO:CONSO00074) positiveCorrelation bp(GO:"neuron death") |
| pubmed:21718217 | a(CONSO:CONSO00074) increases bp(GO:"neuron death") |
| pubmed:29196815 | a(CONSO:CONSO00074) decreases a(MESH:Synapses) |
| pubmed:29196815 | a(CONSO:CONSO00074) decreases a(MESH:Synapses) |
| pubmed:29196815 | a(CONSO:CONSO00074) decreases a(MESH:Synapses) |
| pubmed:29196815 | a(CONSO:CONSO00074) decreases bp(GO:memory) |
| pubmed:29196815 | a(CONSO:CONSO00074) decreases bp(GO:memory) |
| pubmed:29196815 | a(CONSO:CONSO00074) decreases bp(GO:memory) |
| pubmed:29196815 | a(CONSO:CONSO00074) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29196815 | a(CONSO:CONSO00074) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29196815 | a(CONSO:CONSO00074) decreases bp(GO:"neuronal signal transduction") |
| pubmed:29196815 | a(CONSO:CONSO00074) increases path(MESH:Dementia) |
| pubmed:29196815 | a(CONSO:CONSO00074) decreases bp(GO:"long-term synaptic potentiation") |
| pubmed:29196815 | a(CONSO:CONSO00074) decreases bp(GO:"long-term synaptic potentiation") |
| pubmed:29196815 | a(CONSO:CONSO00074) decreases bp(GO:"signal release from synapse") |
| pubmed:29196815 | a(CONSO:CONSO00074) increases bp(GO:"long term synaptic depression") |
| pubmed:29196815 | a(CONSO:CONSO00074) increases p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29196815 | a(CONSO:CONSO00074) increases path(MESH:"Neuroaxonal Dystrophies") |
| pubmed:29196815 | a(CONSO:CONSO00074) increases bp(GO:"microglial cell activation") |
| pubmed:29196815 | a(CONSO:CONSO00074) increases bp(GO:"astrocyte activation") |
| pubmed:29196815 | a(CONSO:CONSO00074) positiveCorrelation bp(GO:"astrocyte activation") |
| pubmed:29196815 | a(CONSO:CONSO00074) positiveCorrelation a(CHEBI:"amyloid fibril") |
| pubmed:29196815 | a(CONSO:CONSO00074) increases act(p(HGNC:GRIN1)) |
| pubmed:29196815 | a(CONSO:CONSO00074) regulates tloc(p(HGNC:GRIA1), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29196815 | a(CONSO:CONSO00074) regulates tloc(p(HGNC:GRIA2), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29196815 | a(CONSO:CONSO00074) increases act(p(HGNC:NGFR)) |
| pubmed:29196815 | a(CONSO:CONSO00074) decreases p(HGNC:INSR) |
| pubmed:29196815 | a(CONSO:CONSO00074) negativeCorrelation a(CONSO:CONSO00352) |
| pubmed:29196815 | a(CONSO:CONSO00074) positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pubmed:29196815 | a(CONSO:CONSO00074) positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pubmed:21718217 | a(CONSO:CONSO00074) decreases bp(GO:"synaptic signaling") |
| pubmed:19293145 | a(MESH:Synapses) increases bp(GO:cognition) |
| pubmed:29196815 | a(CHEBI:"amyloid fibril") causesNoChange bp(GO:memory) |
| pubmed:29196815 | a(CHEBI:"amyloid fibril") positiveCorrelation a(CONSO:CONSO00074) |
| pubmed:22110360 | p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) increases a(CHEBI:amyloid-beta) |
| pubmed:24653673 | p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation act(p(HGNC:GSK3B)) |
| pubmed:24653673 | p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation act(p(HGNC:CDK5)) |
| pubmed:24653673 | p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation act(p(FPLX:ERK)) |
| pubmed:24653673 | p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation a(CHEBI:homocysteine) |
| pubmed:24653673 | p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) |
| pubmed:29196815 | act(p(HGNC:GRIN1)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular region"), toLoc(GO:"intracellular part")) |
| pubmed:29196815 | act(p(HGNC:GRIN1)) increases path(CONSO:CONSO00068) |
| pubmed:29196815 | act(p(HGNC:GRIN1)) increases path(CONSO:CONSO00037) |
| pubmed:29196815 | act(p(HGNC:GRIN1)) decreases a(MESH:Synapses) |
| pubmed:19419557 | act(p(HGNC:GRIN1)) increases a(CHEBI:"nitric oxide") |
| pubmed:19419557 | act(p(HGNC:GRIN1)) increases bp(GO:"negative regulation of calcium-mediated signaling") |
| pubmed:27041503 | p(HGNC:GRIA1) decreases bp(GO:"long-term synaptic potentiation") |
| pubmed:24760868 | p(HGNC:GRIA1) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pubmed:24760868 | p(HGNC:GRIA1) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pubmed:23393546 | p(HGNC:GRIA2) association path(DOID:"Huntington's disease") |
| pubmed:29196815 | a(CONSO:CONSO00075) decreases p(MGI:Adrb2) |
| pubmed:29196815 | a(CONSO:CONSO00075) increases bp(GO:"microglial cell activation") |
| pubmed:29196815 | a(CONSO:CONSO00075) decreases bp(GO:"long-term synaptic potentiation") |
| pubmed:29196815 | complex(a(CONSO:CONSO00074), p(HGNC:PRNP)) decreases bp(GO:"regulation of synaptic plasticity") |
| pubmed:29196815 | p(HGNC:PRNP) decreases a(CHEBI:"amyloid fibril") |
| pubmed:21722302 | p(HGNC:PRNP) association bp(GO:"neuron development") |
| pubmed:21722302 | p(HGNC:PRNP) association bp(GO:"neuron death") |
| pubmed:21722302 | p(HGNC:PRNP) decreases bp(MESH:"Oxidative Stress") |
| pubmed:21722302 | p(HGNC:PRNP) decreases p(HGNC:TNF) |
| pubmed:21722302 | p(HGNC:PRNP) decreases p(HGNC:BAX) |
| pubmed:14556719 | p(HGNC:PRNP) increases complex(a(CHEBI:"copper(2+)"), p(HGNC:PRNP)) |
| pubmed:14556719 | tloc(p(HGNC:PRNP), fromLoc(MESH:"Endoplasmic Reticulum"), toLoc(GO:cytosol)) increases deg(p(HGNC:PRNP)) |
| pubmed:28420982 | p(HGNC:PRNP) association a(CONSO:"Tau oligomers") |
| pubmed:29196815 | a(CONSO:CONSO00023) increases a(CHEBI:"calcium(2+)") |
| pubmed:29196815 | a(CONSO:CONSO00023) increases complex(p(HGNC:GRIK1), p(HGNC:PRNP)) |
| pubmed:29196815 | a(CONSO:CONSO00023) decreases bp(GO:"signal release from synapse") |
| pubmed:29196815 | p(HGNC:NGFR) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29196815 | p(HGNC:NGFR) positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pubmed:22236693 | p(HGNC:NGFR) regulates act(p(HGNC:NTRK1)) |
| pubmed:22236693 | p(HGNC:NGFR) positiveCorrelation bp(MESH:"Cell Survival") |
| pubmed:22236693 | p(HGNC:NGFR) increases complex(a(CHEBI:amyloid-beta), p(HGNC:NGFR)) |
| pubmed:22236693 | p(HGNC:NGFR) increases complex(p(HGNC:NGF), p(HGNC:NGFR)) |
| pubmed:22236693 | p(HGNC:NGFR) association bp(GO:"regulation of cell death") |
| pubmed:18986241 | p(HGNC:NGFR) association bp(GO:"regulation of neuron death") |
| pubmed:18986241 | p(HGNC:NGFR) increases act(p(HGNC:BACE1)) |
| pubmed:18986241 | p(HGNC:NGFR) increases a(CHEBI:amyloid-beta) |
| pubmed:18986241 | act(p(HGNC:NGFR)) association bp(GO:"sphingolipid metabolic process") |
| pubmed:18986241 | act(p(HGNC:NGFR)) increases bp(GO:"JNK cascade") |
| pubmed:18986241 | act(p(HGNC:NGFR)) increases bp(GO:"NIK/NF-kappaB signaling") |
| pubmed:18986241 | act(p(HGNC:NGFR)) increases bp(GO:"protein kinase B signaling") |
| pubmed:18986241 | act(p(HGNC:NGFR)) increases bp(GO:"MAPK cascade") |
| pubmed:22142809 | p(HGNC:NGFR) association p(CONSO:RAC1b) |
| pubmed:29196815 | a(CONSO:CONSO00352) negativeCorrelation a(CONSO:CONSO00074) |
| pubmed:29196815 | path(MESH:"Cognitive Dysfunction") positiveCorrelation a(CONSO:CONSO00074) |
| pubmed:29196815 | path(MESH:"Cognitive Dysfunction") positiveCorrelation a(CONSO:CONSO00074) |
| pubmed:29196815 | path(MESH:"Cognitive Dysfunction") positiveCorrelation p(HGNC:NGFR) |
| pubmed:19293145 | path(MESH:"Cognitive Dysfunction") positiveCorrelation a(CONSO:"amyloid-beta oligomers") |
| pubmed:19293145 | path(MESH:"Cognitive Dysfunction") association path(MESH:"Alzheimer Disease") |
| pubmed:24511233 | path(MESH:"Cognitive Dysfunction") association path(MESH:"Alzheimer Disease") |
| pubmed:24511233 | path(MESH:"Cognitive Dysfunction") association path(MESH:"Alzheimer Disease") |
| pubmed:26813123 | path(MESH:"Cognitive Dysfunction") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24511233 | path(MESH:"Cognitive Dysfunction") association path(MESH:Schizophrenia) |
| pubmed:26813123 | path(MESH:"Cognitive Dysfunction") negativeCorrelation a(GO:synapse) |
| pubmed:26813123 | path(MESH:"Cognitive Dysfunction") association act(p(HGNC:CHRM1)) |
| pubmed:18986241 | path(MESH:"Cognitive Dysfunction") association p(HGNC:CHRM1) |
| pubmed:27522251 | path(MESH:"Cognitive Dysfunction") increases path(MESH:"Plaque, Amyloid") |
| pubmed:21482353 | path(MESH:"Cognitive Dysfunction") association p(HGNC:LYNX1) |
| pubmed:18986241 | path(MESH:"Cognitive Dysfunction") association path(CONSO:mdMCI) |
| pubmed:18986241 | path(MESH:"Cognitive Dysfunction") association path(MESH:"Prodromal Symptoms") |
| pubmed:18986241 | path(MESH:"Cognitive Dysfunction") association path(CONSO:Neurodegeneration) |
| pubmed:18986241 | path(MESH:"Cognitive Dysfunction") causesNoChange act(p(HGNC:CHAT)) |
| pubmed:18986241 | path(MESH:"Cognitive Dysfunction") increases act(p(HGNC:CHAT)) |
| pubmed:18986241 | path(MESH:"Cognitive Dysfunction") increases act(p(HGNC:CHAT)) |
| pubmed:18986241 | path(MESH:"Cognitive Dysfunction") decreases a(MESH:Synapses) |
| pubmed:18986241 | path(MESH:"Cognitive Dysfunction") association p(HGNC:BCHE, var("p.Ala539Thr")) |
| pubmed:18986241 | path(MESH:"Cognitive Dysfunction") increases a(MESH:"pro-nerve growth factor, human") |
| pubmed:18986241 | path(MESH:"Cognitive Dysfunction") increases act(p(HGNC:MMP9)) |
| pubmed:18986241 | path(MESH:"Cognitive Dysfunction") causesNoChange r(HGNC:CHAT) |
| pubmed:18986241 | path(MESH:"Cognitive Dysfunction") decreases p(CONSO:"3R tau") |
| pubmed:11230871 | path(MESH:"Cognitive Dysfunction") negativeCorrelation p(FPLX:CHRN) |
| pubmed:29687724 | path(MESH:"Cognitive Dysfunction") association path(MESH:"Huntington Disease") |
| pubmed:29687724 | path(MESH:"Cognitive Dysfunction") isA path(MESH:"Neurocognitive Disorders") |
| pubmed:29687724 | path(MESH:"Cognitive Dysfunction") decreases path(MESH:Thinking) |
| pubmed:29687724 | path(MESH:"Cognitive Dysfunction") decreases path(MESH:"Executive Function") |
| pubmed:29687724 | path(MESH:"Cognitive Dysfunction") decreases path(MESH:Memory) |
| pubmed:24027553 | path(MESH:"Cognitive Dysfunction") positiveCorrelation path(MESH:Tauopathies) |
| pubmed:30108137 | path(MESH:"Cognitive Dysfunction") positiveCorrelation r(HGNC:TFEB) |
| pubmed:30126037 | path(MESH:"Cognitive Dysfunction") association p(HGNC:CDKN2A) |
| pubmed:30126037 | path(MESH:"Cognitive Dysfunction") association bp(MESH:"Cerebrovascular Circulation") |
| pubmed:19765634 | path(MESH:"Cognitive Dysfunction") positiveCorrelation g(DBSNP:rs8052688) |
| pubmed:19765634 | path(MESH:"Cognitive Dysfunction") positiveCorrelation g(DBSNP:rs8063) |
| pubmed:28669544 | path(MESH:"Cognitive Dysfunction") positiveCorrelation path(MESH:"Neuronal Plasticity") |
| pubmed:29196815 | a(CONSO:CONSO00076) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29196815 | a(CONSO:CONSO00076) biomarkerFor path(MESH:"Alzheimer Disease") |
| pubmed:18650430 | p(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") |
| pubmed:14556719 | p(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | p(HGNC:APP, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | p(HGNC:APP, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:18650430 | p(HGNC:APP, var("?")) increases path(MESH:"Cerebral Amyloid Angiopathy, Familial") |
| pubmed:29758300 | p(HGNC:APP, var("?")) increases bp(GO:mitophagy) |
| pubmed:14556719 | p(HGNC:APP, var("?")) increases a(CONSO:"amyloid-beta aggregates") |
| pubmed:22908190 | p(HGNC:APP, var("?")) negativeCorrelation act(a(MESH:Neurites)) |
| pubmed:28420982 | path(MESH:"Cerebral Amyloid Angiopathy, Familial") association a(MESH:"Heparan Sulfate Proteoglycans") |
| pubmed:18650430 | act(p(HGNC:ADAM17), ma(go:0008233 ! "peptidase activity")) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) |
| pubmed:21214928 | p(HGNC:ADAM17) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00067))) |
| pubmed:22122372 | p(HGNC:ADAM17) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00067))) |
| pubmed:22122372 | p(HGNC:ADAM17) increases p(CONSO:CONSO00067) |
| pubmed:18650430 | act(p(HGNC:ADAM9), ma(go:0008233 ! "peptidase activity")) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) |
| pubmed:22122372 | p(HGNC:ADAM9) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00067))) |
| pubmed:22122372 | p(HGNC:ADAM9) increases p(CONSO:CONSO00067) |
| pubmed:18650430 | act(p(HGNC:ADAM10), ma(go:0008233 ! "peptidase activity")) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) |
| pubmed:21214928 | p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) |
| pubmed:21214928 | p(HGNC:ADAM10) increases p(CONSO:CONSO00067) |
| pubmed:22122372 | p(HGNC:ADAM10) increases p(CONSO:CONSO00067) |
| pubmed:21214928 | p(HGNC:ADAM10) decreases a(CHEBI:amyloid-beta) |
| pubmed:21214928 | p(HGNC:ADAM10) decreases a(CHEBI:amyloid-beta) |
| pubmed:22122372 | p(HGNC:ADAM10) decreases a(CHEBI:amyloid-beta) |
| pubmed:21214928 | p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00067))) |
| pubmed:21214928 | p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00067))) |
| pubmed:22122372 | p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00067))) |
| pubmed:22122372 | p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00067))) |
| pubmed:21214928 | p(HGNC:ADAM10) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21214928 | act(p(HGNC:ADAM10)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22122372 | p(HGNC:ADAM10) increases tloc(p(HGNC:APP), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:24590577 | p(HGNC:ADAM10) increases deg(p(HGNC:APP)) |
| pubmed:22122372 | p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00067), p(CONSO:CONSO00072))) |
| pubmed:22122372 | p(HGNC:ADAM10) decreases path(MESH:"Plaque, Amyloid") |
| pubmed:28499950 | act(p(HGNC:ADAM10)) directlyIncreases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, frag("421_*")))) |
| pubmed:24590577 | p(HGNC:ADAM10) increases p(CONSO:sAPP-alpha) |
| pubmed:18650430 | act(p(HGNC:BACE2), ma(go:0008233 ! "peptidase activity")) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) |
| pubmed:21214928 | p(HGNC:BACE2) association rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) |
| pubmed:21214928 | p(HGNC:BACE2) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) |
| pubmed:18650430 | complex(FPLX:"Gamma_secretase") increases a(MESH:"Amyloid beta-Peptides") |
| pubmed:18650430 | complex(FPLX:"Gamma_secretase") increases p(CONSO:CONSO00071) |
| pubmed:22122372 | complex(FPLX:"Gamma_secretase") increases p(CONSO:CONSO00071) |
| pubmed:21214928 | complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) |
| pubmed:22122372 | complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) |
| pubmed:21722302 | complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) |
| pubmed:21214928 | complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(CONSO:CONSO00024)), products(a(CHEBI:amyloid-beta), p(CONSO:CONSO00072))) |
| pubmed:21214928 | complex(FPLX:"Gamma_secretase") increases p(CONSO:CONSO00024, frag("?")) |
| pubmed:21214928 | complex(FPLX:"Gamma_secretase") increases p(HGNC:NOTCH1, frag("?")) |
| pubmed:21214928 | complex(FPLX:"Gamma_secretase") increases p(FPLX:Cadherin, frag("?")) |
| pubmed:21214928 | complex(FPLX:"Gamma_secretase") increases p(HGNC:TYR, frag("?")) |
| pubmed:21214928 | complex(FPLX:"Gamma_secretase") increases p(HGNC:ERBB4, frag("?")) |
| pubmed:21214928 | complex(FPLX:"Gamma_secretase") increases p(HGNC:CD44, frag("?")) |
| pubmed:22122372 | complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(CONSO:CONSO00072)), products(p(CONSO:CONSO00071), p(CONSO:CONSO00080))) |
| pubmed:22122372 | complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(CONSO:CONSO00081)), products(a(MESH:"Amyloid beta-Peptides"), p(CONSO:CONSO00071))) |
| pubmed:22122372 | complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("1_38")) |
| pubmed:22122372 | complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("1_43")) |
| pubmed:22122372 | complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("672_711")) |
| pubmed:21722302 | complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("672_711")) |
| pubmed:24590577 | complex(FPLX:"Gamma_secretase") increases deg(p(CONSO:C99)) |
| pubmed:24590577 | complex(FPLX:"Gamma_secretase") increases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | complex(FPLX:"Gamma_secretase") increases a(CHEBI:amyloid-beta) |
| pubmed:24590577 | complex(FPLX:"Gamma_secretase") increases p(CONSO:AICD) |
| pubmed:21722302 | complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("672_713")) |
| pubmed:21722302 | complex(FPLX:"Gamma_secretase") negativeCorrelation p(HGNC:UBQLN1) |
| pubmed:26968346 | p(HGNC:PSEN2) positiveCorrelation bp(GO:"autophagosome-lysosome fusion") |
| pubmed:26968346 | p(HGNC:PSEN2) positiveCorrelation bp(GO:"endomembrane system organization") |
| pubmed:26968346 | p(HGNC:PSEN2) positiveCorrelation bp(GO:"sequestering of calcium ion") |
| pubmed:21718217 | p(HGNC:APH1A) decreases p(HGNC:APP) |
| pubmed:21718217 | p(HGNC:APH1A) increases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:18650430 | p(HGNC:APBA1) decreases a(CHEBI:amyloid-beta) |
| pubmed:18650430 | p(HGNC:APBA1) decreases a(CONSO:CONSO00018) |
| pubmed:18650430 | p(HGNC:APBA1) regulates bp(CONSO:CONSO00073) |
| pubmed:21214928 | bp(CONSO:CONSO00073) association p(HGNC:RAB6A) |
| pubmed:22122372 | bp(CONSO:CONSO00073) association p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 654)) |
| pubmed:22122372 | bp(CONSO:CONSO00073) association p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) |
| pubmed:22122372 | bp(CONSO:CONSO00073) association p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Ser, 665)) |
| pubmed:22122372 | bp(CONSO:CONSO00073) association complex(p(CONSO:CONSO00071), p(HGNC:MAPK8IP1)) |
| pubmed:18650430 | p(HGNC:APBA2) decreases a(CHEBI:amyloid-beta) |
| pubmed:18650430 | p(HGNC:APBA2) decreases a(CONSO:CONSO00018) |
| pubmed:18650430 | p(HGNC:APBA2) regulates bp(CONSO:CONSO00073) |
| pubmed:18650430 | p(HGNC:APBB1) decreases a(CHEBI:amyloid-beta) |
| pubmed:18650430 | p(HGNC:APBB1) decreases a(CONSO:CONSO00018) |
| pubmed:18650430 | p(HGNC:APBB1) regulates bp(CONSO:CONSO00073) |
| pubmed:18650430 | p(HGNC:APBB1) increases p(CONSO:CONSO00071) |
| pubmed:21034527 | p(HGNC:APBB1) association act(p(HGNC:SP1), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:21214928 | act(p(CONSO:CONSO00071), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates p(HGNC:APP) |
| pubmed:21214928 | act(p(CONSO:CONSO00071), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates p(HGNC:GSK3B) |
| pubmed:21214928 | act(p(CONSO:CONSO00071), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates p(HGNC:CD82) |
| pubmed:21214928 | act(p(CONSO:CONSO00071), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates p(HGNC:MME) |
| pubmed:21214928 | act(p(CONSO:CONSO00071), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates p(HGNC:BACE1) |
| pubmed:21214928 | act(p(CONSO:CONSO00071), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates p(HGNC:EGFR) |
| pubmed:21214928 | act(p(CONSO:CONSO00071), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates p(HGNC:LRP1) |
| pubmed:21214928 | p(CONSO:CONSO00071) increases bp(GO:"apoptotic process") |
| pubmed:22122372 | act(p(CONSO:CONSO00071)) association p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 654)) |
| pubmed:22122372 | act(p(CONSO:CONSO00071)) association p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) |
| pubmed:22122372 | act(p(CONSO:CONSO00071)) association p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Ser, 665)) |
| pubmed:22122372 | p(CONSO:CONSO00071) increases bp(GO:"cell death") |
| pubmed:22122372 | p(CONSO:CONSO00071) increases p(HGNC:TP53) |
| pubmed:22122372 | p(CONSO:CONSO00071) increases act(p(HGNC:TP53)) |
| pubmed:22122372 | p(CONSO:CONSO00071) regulates bp(GO:"calcium ion homeostasis") |
| pubmed:18650430 | p(HGNC:SORL1) decreases a(CHEBI:amyloid-beta) |
| pubmed:21214928 | p(HGNC:SORL1) decreases a(CHEBI:amyloid-beta) |
| pubmed:29758300 | p(HGNC:SORL1) negativeCorrelation a(CHEBI:amyloid-beta) |
| pubmed:26996954 | p(HGNC:SORL1) association p(HGNC:APP) |
| pubmed:26996954 | p(HGNC:SORL1) decreases p(HGNC:APP) |
| pubmed:26996954 | p(HGNC:SORL1) association g(DBSNP:rs3824968) |
| pubmed:26996954 | p(HGNC:SORL1) association a(NIFT:"Grey matter volume") |
| pubmed:26996954 | p(HGNC:SORL1) increases p(HGNC:APP, frag("672_713")) |
| pubmed:29758300 | p(HGNC:SORL1) association path(MESH:"Alzheimer Disease") |
| pubmed:18650430 | composite(p(HGNC:APP), p(HGNC:CNTN2)) decreases bp(GO:neurogenesis) |
| pubmed:26813123 | p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) |
| pubmed:26813123 | p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) |
| pubmed:26813123 | p(HGNC:SLC5A7) increases a(CHEBI:choline) |
| pubmed:26813123 | p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) |
| pubmed:26813123 | p(HGNC:SLC5A7) increases a(CHEBI:acetylcholine) |
| pubmed:17293005 | p(HGNC:BACE1, frag("67_78")) decreases tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17293005 | p(HGNC:BACE1, frag("67_78")) decreases p(CONSO:sAPP-beta) |
| pubmed:17293005 | p(HGNC:BACE1, frag("67_78")) decreases tloc(p(CONSO:sAPP-alpha), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17293005 | p(HGNC:BACE1, frag("67_78")) increases p(CONSO:sAPP-alpha, loc(GO:intracellular)) |
| pubmed:17293005 | p(HGNC:BACE1, frag("67_78")) increases p(CONSO:sAPP-alpha) |
| pubmed:17293005 | p(HGNC:BACE1, frag("67_78")) causesNoChange a(CHEBI:amyloid-beta) |
| pubmed:17293005 | p(HGNC:BACE1, frag("67_78")) causesNoChange p(HGNC:ACTB) |
| pubmed:17293005 | p(HGNC:BACE1, frag("67_78")) causesNoChange act(p(HGNC:BACE1)) |
| pubmed:17293005 | p(HGNC:BACE1, frag("67_78")) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pubmed:17293005 | p(HGNC:BACE1, frag("69_75")) causesNoChange tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17293005 | p(HGNC:BACE1, frag("69_75")) causesNoChange tloc(p(CONSO:sAPP-alpha), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17293005 | p(HGNC:BACE1, frag("69_75")) causesNoChange a(CHEBI:amyloid-beta) |
| pubmed:17293005 | p(HGNC:BACE1, frag("69_75")) causesNoChange p(HGNC:ACTB) |
| pubmed:17293005 | p(HGNC:BACE1, frag("228_236")) decreases tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17293005 | p(HGNC:BACE1, frag("228_236")) decreases p(CONSO:sAPP-beta) |
| pubmed:17293005 | p(HGNC:BACE1, frag("228_236")) decreases tloc(p(CONSO:sAPP-alpha), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17293005 | p(HGNC:BACE1, frag("228_236")) increases p(CONSO:sAPP-alpha, loc(GO:intracellular)) |
| pubmed:17293005 | p(HGNC:BACE1, frag("228_236")) increases p(CONSO:sAPP-alpha) |
| pubmed:17293005 | p(HGNC:BACE1, frag("228_236")) causesNoChange a(CHEBI:amyloid-beta) |
| pubmed:17293005 | p(HGNC:BACE1, frag("228_236")) causesNoChange p(HGNC:ACTB) |
| pubmed:17293005 | p(HGNC:BACE1, frag("228_236")) causesNoChange act(p(HGNC:BACE1)) |
| pubmed:17293005 | p(HGNC:BACE1, frag("228_236")) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pubmed:17293005 | p(HGNC:BACE1, frag("230_235")) causesNoChange tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17293005 | p(HGNC:BACE1, frag("230_235")) causesNoChange tloc(p(CONSO:sAPP-alpha), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17293005 | p(HGNC:BACE1, frag("230_235")) causesNoChange a(CHEBI:amyloid-beta) |
| pubmed:17293005 | p(HGNC:BACE1, frag("230_235")) causesNoChange p(HGNC:ACTB) |
| pubmed:21214928 | rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) association p(HGNC:BACE2) |
| pubmed:21214928 | a(MESH:"Amyloid Precursor Protein Secretases") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) |
| pubmed:26813123 | a(MESH:"Amyloid Precursor Protein Secretases") decreases a(MESH:"Amyloid beta-Peptides") |
| pubmed:14556719 | a(MESH:"Amyloid Precursor Protein Secretases") increases rxn(reactants(p(HGNC:APP)), products(a(MESH:"Amyloid beta-Peptides"))) |
| pubmed:21214928 | p(CONSO:CONSO00067) decreases path(CONSO:CONSO00061) |
| pubmed:22122372 | p(CONSO:CONSO00067) decreases path(CONSO:CONSO00061) |
| pubmed:22122372 | tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) decreases path(CONSO:CONSO00061) |
| pubmed:21214928 | p(CONSO:CONSO00067) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21214928 | p(CONSO:CONSO00067) association bp(GO:"regulation of neuronal synaptic plasticity") |
| pubmed:21214928 | p(CONSO:CONSO00067) regulates bp(GO:"central nervous system formation") |
| pubmed:21214928 | p(CONSO:CONSO00067) decreases path(CONSO:CONSO00068) |
| pubmed:21214928 | p(CONSO:CONSO00067) decreases path(CONSO:CONSO00068) |
| pubmed:21214928 | p(CONSO:CONSO00067) regulates bp(GO:"stem cell proliferation") |
| pubmed:21214928 | p(CONSO:CONSO00067) decreases act(p(HGNC:CDK5)) |
| pubmed:21214928 | p(CONSO:CONSO00067) association complex(p(HGNC:APBA1), p(HGNC:APP)) |
| pubmed:21214928 | tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association complex(p(HGNC:APBA1), p(HGNC:APP)) |
| pubmed:21214928 | p(CONSO:CONSO00067) association complex(p(HGNC:APBA2), p(HGNC:APP)) |
| pubmed:21214928 | tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association complex(p(HGNC:APBA2), p(HGNC:APP)) |
| pubmed:21214928 | p(CONSO:CONSO00067) association complex(p(HGNC:APBA3), p(HGNC:APP)) |
| pubmed:21214928 | tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association complex(p(HGNC:APBA3), p(HGNC:APP)) |
| pubmed:21214928 | tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association a(CHEBI:"phorbol ester") |
| pubmed:22122372 | p(CONSO:CONSO00067) increases bp(GO:"cell adhesion") |
| pubmed:22122372 | p(CONSO:CONSO00067) increases bp(MESH:"Neuronal Outgrowth") |
| pubmed:22122372 | p(CONSO:CONSO00067) increases bp(GO:"synapse assembly") |
| pubmed:22122372 | p(CONSO:CONSO00067) increases bp(GO:learning) |
| pubmed:22122372 | p(CONSO:CONSO00067) increases bp(GO:memory) |
| pubmed:21214928 | bp(CONSO:CONSO00077) increases p(CONSO:CONSO00063) |
| pubmed:22122372 | bp(CONSO:CONSO00077) increases p(CONSO:CONSO00063) |
| pubmed:21214928 | bp(CONSO:CONSO00077) increases p(CONSO:CONSO00064) |
| pubmed:22122372 | bp(CONSO:CONSO00077) increases p(CONSO:CONSO00064) |
| pubmed:21214928 | bp(CONSO:CONSO00077) increases p(CONSO:CONSO00065) |
| pubmed:21214928 | p(CONSO:CONSO00064) association p(UNIPROT:A0A293M1A7) |
| pubmed:21214928 | p(CONSO:CONSO00064) increases path(MESH:"Plaque, Amyloid") |
| pubmed:22122372 | p(CONSO:CONSO00064) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21214928 | p(CONSO:CONSO00065) association p(UNIPROT:A0A293M1A7) |
| pubmed:21214928 | p(CONSO:CONSO00065) increases path(MESH:"Plaque, Amyloid") |
| pubmed:21214928 | p(CONSO:CONSO00065) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22122372 | p(CONSO:CONSO00065) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21214928 | p(UNIPROT:A0A293M1A7) association p(CONSO:CONSO00064) |
| pubmed:21214928 | p(UNIPROT:A0A293M1A7) association p(CONSO:CONSO00065) |
| pubmed:21214928 | r(CONSO:CONSO00064) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21214928 | bp(GO:"signal transduction") association p(HGNC:APP) |
| pubmed:17403556 | bp(GO:"signal transduction") increases complex(a(CONSO:"amyloid-beta derived diffusible ligands"), p(HGNC:MAPT)) |
| pubmed:29311797 | bp(GO:"signal transduction") association p(HGNC:HSP90AB1) |
| pubmed:21214928 | bp(GO:"protein transport") association p(HGNC:APP) |
| pubmed:31413141 | bp(GO:"protein transport") association p(HGNC:MS4A4A, loc(GO:"plasma membrane")) |
| pubmed:31413141 | bp(GO:"protein transport") association p(HGNC:MS4A4A, loc(GO:cytoplasm)) |
| pubmed:30740335 | bp(GO:"protein transport") increases p(HGNC:ATF6) |
| pubmed:27299292 | bp(GO:"protein transport") negativeCorrelation p(HGNC:GBA, var("p.Leu444Pro")) |
| pubmed:27299292 | bp(GO:"protein transport") positiveCorrelation p(HGNC:TFEB) |
| pubmed:23746257 | bp(GO:"protein transport") association p(FPLX:HSP90) |
| pubmed:22122372 | complex(a(CHEBI:amyloid-beta), p(HGNC:APP)) regulates bp(CONSO:CONSO00073) |
| pubmed:22122372 | complex(p(HGNC:APP), p(HGNC:SPON1)) regulates bp(CONSO:CONSO00073) |
| pubmed:22122372 | complex(p(HGNC:APP), p(HGNC:NTN1)) regulates bp(CONSO:CONSO00073) |
| pubmed:27068745 | p(HGNC:NTN1) decreases bp(GO:"neuron apoptotic process") |
| pubmed:21214928 | bp(GO:"anterograde axonal protein transport") association p(HGNC:APP) |
| pubmed:21214928 | complex(p(HGNC:APP), p(HGNC:KIF5B)) regulates act(p(HGNC:BACE1)) |
| pubmed:21214928 | complex(p(HGNC:APP), p(HGNC:KIF5B)) regulates act(p(HGNC:PSEN1)) |
| pubmed:19491104 | p(HGNC:KIF5B) isA complex(GO:"kinesin complex") |
| pubmed:19491104 | p(HGNC:KIF5B) increases complex(a(MESH:Microtubules), p(HGNC:KIF5B)) |
| pubmed:26813123 | complex(p(HGNC:APP), p(HGNC:SLC5A7)) increases tloc(p(HGNC:APP), fromLoc(GO:"cell surface"), toLoc(GO:intracellular)) |
| pubmed:21214928 | composite(a(CHEBI:"phorbol ester"), p(HGNC:ADAM9), p(HGNC:APP)) increases p(CONSO:CONSO00067) |
| pubmed:21214928 | a(CHEBI:"phorbol ester") association tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21214928 | a(CHEBI:"phorbol ester") association a(CHEBI:amyloid-beta) |
| pubmed:21214928 | a(CHEBI:"phorbol ester") increases act(p(HGNC:PRKCA)) |
| pubmed:21214928 | bp(GO:"regulation of neuronal synaptic plasticity") association p(CONSO:CONSO00067) |
| pubmed:12428809 | bp(GO:"regulation of neuronal synaptic plasticity") association tloc(p(HGNC:APP), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21214928 | complex(p(HGNC:BACE1), p(HGNC:RTN4)) decreases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) |
| pubmed:21214928 | complex(p(HGNC:BACE1), p(HGNC:GGA1)) decreases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) |
| pubmed:19126755 | bp(GO:"synaptic transmission, cholinergic") increases bp(GO:cognition) |
| pubmed:24511233 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition) |
| pubmed:26813123 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition) |
| pubmed:21482353 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition) |
| pubmed:19126755 | bp(GO:"synaptic transmission, cholinergic") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26813123 | bp(GO:"synaptic transmission, cholinergic") association path(MESH:"Alzheimer Disease") |
| pubmed:19293145 | bp(GO:"synaptic transmission, cholinergic") association a(CHEBI:amyloid-beta) |
| pubmed:19293145 | bp(GO:"synaptic transmission, cholinergic") association a(CHEBI:amyloid-beta) |
| pubmed:24511233 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:behavior) |
| pubmed:24511233 | bp(GO:"synaptic transmission, cholinergic") association path(MESH:Schizophrenia) |
| pubmed:27190210 | bp(GO:"synaptic transmission, cholinergic") regulates p(HGNC:CHRNA7) |
| pubmed:27190210 | bp(GO:"synaptic transmission, cholinergic") association bp(MESH:Neuroprotection) |
| pubmed:27190210 | bp(GO:"synaptic transmission, cholinergic") association path(DOID:"Parkinson's disease") |
| pubmed:27190210 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:"oxygen homeostasis") |
| pubmed:27190210 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:"glucose homeostasis") |
| pubmed:27190210 | bp(GO:"synaptic transmission, cholinergic") association path(DOID:ischemia) |
| pubmed:17009926 | bp(GO:"synaptic transmission, cholinergic") increases act(a(CHEBI:acetylcholine)) |
| pubmed:26813123 | bp(GO:"synaptic transmission, cholinergic") regulates act(a(MESH:Neurons)) |
| pubmed:26813123 | bp(GO:"synaptic transmission, cholinergic") association path(MESH:Attention) |
| pubmed:26813123 | bp(GO:"synaptic transmission, cholinergic") increases path(MESH:Attention) |
| pubmed:26813123 | bp(GO:"synaptic transmission, cholinergic") increases path(MESH:Attention) |
| pubmed:26813123 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:learning) |
| pubmed:26813123 | bp(GO:"synaptic transmission, cholinergic") positiveCorrelation bp(GO:learning) |
| pubmed:21482353 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:learning) |
| pubmed:26813123 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:memory) |
| pubmed:21482353 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:memory) |
| pubmed:22040696 | bp(GO:"synaptic transmission, cholinergic") increases bp(GO:memory) |
| pubmed:26813123 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:"response to stress") |
| pubmed:26813123 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:"regulation of circadian sleep/wake cycle, wakefulness") |
| pubmed:26813123 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:"regulation of circadian sleep/wake cycle, sleep") |
| pubmed:26813123 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:"sensory processing") |
| pubmed:21482353 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:"sensory processing") |
| pubmed:26813123 | bp(GO:"synaptic transmission, cholinergic") regulates bp(GO:"circadian sleep/wake cycle") |
| pubmed:26813123 | bp(GO:"synaptic transmission, cholinergic") association path(CONSO:Neurodegeneration) |
| pubmed:26813123 | bp(GO:"synaptic transmission, cholinergic") association path(MESH:Dementia) |
| pubmed:24590577 | bp(GO:"synaptic transmission, cholinergic") association path(MESH:"Plaque, Amyloid") |
| pubmed:24590577 | bp(GO:"synaptic transmission, cholinergic") association path(MESH:"Neurofibrillary Tangles") |
| pubmed:21482353 | bp(GO:"synaptic transmission, cholinergic") association path(MESH:Anxiety) |
| pubmed:21482353 | bp(GO:"synaptic transmission, cholinergic") association path(MESH:Depression) |
| pubmed:21482353 | bp(GO:"synaptic transmission, cholinergic") association p(HGNC:LYNX1) |
| pubmed:11230871 | bp(GO:"synaptic transmission, cholinergic") association a(PUBCHEM:5662) |
| pubmed:21214928 | p(HGNC:APP, frag("672_713")) increases a(CONSO:CONSO00038) |
| pubmed:21214928 | p(HGNC:APP, frag("672_713")) increases a(CONSO:CONSO00038) |
| pubmed:22122372 | p(HGNC:APP, frag("672_713")) increases a(CONSO:CONSO00038) |
| pubmed:21214928 | p(HGNC:APP, frag("672_713")) increases path(MESH:"Alzheimer Disease") |
| pubmed:21214928 | p(HGNC:APP, frag("672_713")) increases a(CONSO:CONSO00022) |
| pubmed:22122372 | p(HGNC:APP, frag("672_713")) increases a(CONSO:CONSO00022) |
| pubmed:21214928 | p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid") |
| pubmed:22122372 | p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid") |
| pubmed:22122372 | p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid") |
| url:"https://www.ncbi.nlm.nih.gov/clinvar/RCV000019448/" | p(HGNC:APP, frag("672_713")) isA a(CHEBI:amyloid-beta) |
| pubmed:25468261 | p(HGNC:APP, frag("672_713")) positiveCorrelation a(CONSO:"CDR - Sum of Boxes") |
| pubmed:19926167 | p(HGNC:APP, frag("672_713")) association p(HGNC:CTSD) |
| pubmed:23022416 | p(HGNC:APP, frag("672_713")) negativeCorrelation g(DBSNP:rs3818361) |
| pubmed:22107728 | p(HGNC:APP, frag("672_713")) positiveCorrelation g(DBSNP:rs4646953) |
| pubmed:21673407 | p(HGNC:APP, frag("672_713")) positiveCorrelation complex(a(NIFT:"Pittsburgh Compound B"), p(HGNC:HTR4)) |
| pubmed:22550605 | p(HGNC:APP, frag("672_713")) increases a(CHEBI:"reactive oxygen species") |
| pubmed:21543606 | p(HGNC:APP, frag("672_713")) association p(HGNC:CLU) |
| pubmed:21543606 | p(HGNC:APP, frag("672_713")) decreases a(MESH:Oligodendroglia) |
| pubmed:14970312 | p(HGNC:APP, frag("672_713")) increases bp(MESH:"Oxidative Stress") |
| pubmed:14970312 | p(HGNC:APP, frag("672_713")) increases bp(MESH:"Oxidative Stress") |
| pubmed:14970312 | p(HGNC:APP, frag("672_713")) increases a(CHEBI:ceramide) |
| pubmed:14970312 | p(HGNC:APP, frag("672_713")) increases a(CHEBI:cholesterol) |
| pubmed:14970312 | p(HGNC:APP, frag("672_713")) association bp(GO:"regulation of lipid metabolic process") |
| pubmed:21722302 | p(HGNC:APP, frag("672_713")) isA a(MESH:"Amyloidogenic Proteins") |
| pubmed:21722302 | p(HGNC:APP, frag("672_713")) increases path(HP:"Senile plaques") |
| pubmed:27094130 | tloc(p(HGNC:APP, frag("672_713")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) positiveCorrelation act(p(HGNC:DAPK1), ma(go:0016301 ! "kinase activity")) |
| pubmed:29540553 | p(HGNC:APP, frag("672_713")) decreases p(MGI:Sirt3) |
| pubmed:29559585 | p(HGNC:APP, frag("672_713")) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:29559585 | p(HGNC:APP, frag("672_713")) increases a(CHEBI:"nitric oxide") |
| pubmed:22122372 | p(HGNC:APP, frag("672_711")) decreases path(CONSO:CONSO00061) |
| url:"https://www.ncbi.nlm.nih.gov/clinvar/RCV000019448/" | p(HGNC:APP, frag("672_711")) isA a(CHEBI:amyloid-beta) |
| pubmed:24401760 | p(HGNC:APP, frag("672_711")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21214928 | path(MESH:"Down Syndrome") increases a(CONSO:CONSO00018) |
| pubmed:17009926 | path(MESH:"Down Syndrome") negativeCorrelation act(p(FPLX:CHRN)) |
| pubmed:17009926 | path(MESH:"Down Syndrome") negativeCorrelation p(FPLX:CHRN) |
| pubmed:26813123 | path(MESH:"Down Syndrome") negativeCorrelation a(MESH:"Cholinergic Neurons") |
| pubmed:22299660 | path(MESH:"Down Syndrome") negativeCorrelation p(FPLX:PPP2) |
| pubmed:22908190 | path(MESH:"Down Syndrome") negativeCorrelation bp(GO:"regulation of endosome size") |
| pubmed:28137862 | path(MESH:"Down Syndrome") association p(HGNC:DYRK1A) |
| pubmed:28250274 | path(MESH:"Down Syndrome") negativeCorrelation p(HGNC:MME) |
| pubmed:21214928 | p(HGNC:CTSB) increases a(CHEBI:amyloid-beta) |
| pubmed:22122372 | p(HGNC:CTSB) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:23516100 | p(HGNC:CTSB) increases act(p(HGNC:BACE1)) |
| pubmed:23516100 | act(p(HGNC:CTSB)) increases a(CHEBI:"amyloid-beta polypeptide 40", loc(GO:"secretory vesicle")) |
| pubmed:23516100 | p(HGNC:CTSB) increases p(CONSO:"amyloid-beta aggregates") |
| pubmed:23516100 | p(HGNC:CTSB) negativeCorrelation bp(GO:memory) |
| pubmed:22908190 | p(HGNC:CTSB) positiveCorrelation act(a(GO:synapse)) |
| pubmed:21214928 | complex(p(CONSO:CONSO00042), p(HGNC:TNFRSF21)) association bp(GO:"synapse pruning") |
| pubmed:21214928 | complex(p(CONSO:CONSO00042), p(HGNC:TNFRSF21)) association bp(GO:"neuron death") |
| pubmed:21214928 | p(CONSO:CONSO00042) increases p(HGNC:TTR) |
| pubmed:21214928 | p(CONSO:CONSO00042) increases p(HGNC:KL) |
| pubmed:22122372 | p(CONSO:CONSO00042) increases path(CONSO:CONSO00061) |
| pubmed:21214928 | bp(GO:"synapse pruning") association complex(p(CONSO:CONSO00042), p(HGNC:TNFRSF21)) |
| pubmed:21214928 | p(CONSO:CONSO00024) increases path(CONSO:CONSO00027) |
| pubmed:22122372 | p(CONSO:CONSO00069) increases path(CONSO:CONSO00061) |
| pubmed:22122372 | p(CONSO:CONSO00069) increases act(p(HGNC:CASP3)) |
| pubmed:22122372 | p(CONSO:CONSO00069) increases p(HGNC:APP, frag("672_713")) |
| pubmed:22122372 | p(CONSO:CONSO00070) increases path(CONSO:CONSO00061) |
| pubmed:21214928 | complex(p(HGNC:APP), p(HGNC:NCSTN), p(HGNC:NOTCH1)) increases complex(complex(FPLX:"Gamma_secretase"), p(HGNC:APP)) |
| pubmed:21214928 | p(HGNC:BSG) decreases a(CHEBI:amyloid-beta) |
| pubmed:21214928 | p(HGNC:BSG) causesNoChange a(CHEBI:amyloid-beta) |
| pubmed:21214928 | p(HGNC:TMED10) regulates a(CHEBI:amyloid-beta) |
| pubmed:21214928 | complex(complex(FPLX:"Gamma_secretase"), p(CONSO:CONSO00024), p(HGNC:GSAP)) increases a(CHEBI:amyloid-beta) |
| pubmed:30061532 | p(HGNC:ERBB4) association path(MESH:Schizophrenia) |
| pubmed:21718217 | p(HGNC:MME) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:26195256 | p(HGNC:MME) increases deg(a(CHEBI:amyloid-beta, loc(GO:"extracellular region"))) |
| pubmed:29626319 | p(HGNC:MME) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | p(HGNC:MME) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | p(HGNC:MME) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | p(HGNC:MME) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | act(p(HGNC:MME)) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:28250274 | p(HGNC:MME) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:27209302 | p(HGNC:MME) increases deg(p(CONSO:sAPP-beta)) |
| pubmed:30116051 | p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pubmed:30116051 | act(p(HGNC:MME)) decreases path(MESH:"Plaque, Amyloid") |
| pubmed:29626319 | p(HGNC:MME) increases bp(GO:behavior) |
| pubmed:28250274 | p(HGNC:MME) negativeCorrelation path(MESH:"Down Syndrome") |
| pubmed:28250274 | p(HGNC:MME) negativeCorrelation p(HGNC:DYRK1A) |
| pubmed:24653673 | p(HGNC:EGFR) increases p(HGNC:PPP2CA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) |
| pubmed:24653673 | p(HGNC:EGFR) increases p(HGNC:PPP2CB, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) |
| pubmed:23393546 | p(HGNC:EGFR) increases bp(GO:"MAPK cascade") |
| pubmed:30640040 | p(HGNC:EGFR) association a(PUBCHEM:24756910) |
| pubmed:21214928 | complex(p(CONSO:CONSO00069), p(HGNC:APP)) increases p(CONSO:CONSO00069) |
| pubmed:22122372 | bp(GO:"neurofibrillary tangle assembly") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22122372 | bp(GO:"neurofibrillary tangle assembly") association path(MESH:"Alzheimer Disease") |
| pubmed:25687773 | bp(GO:"neurofibrillary tangle assembly") association g(DBSNP:rs393152) |
| pubmed:30108137 | bp(GO:"neurofibrillary tangle assembly") increases g(HGNC:TFEB) |
| pubmed:28420982 | bp(GO:"neurofibrillary tangle assembly") association a(MESH:"Heparan Sulfate Proteoglycans") |
| pubmed:19363271 | bp(GO:"neurofibrillary tangle assembly") positiveCorrelation p(FPLX:HSP90) |
| pubmed:17050703 | bp(GO:"neurofibrillary tangle assembly") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) |
| pubmed:22122372 | a(CONSO:CONSO00038) increases path(MESH:"Plaque, Amyloid") |
| pubmed:21718217 | a(CONSO:CONSO00038) increases p(HGNC:CCL2) |
| pubmed:21718217 | a(CONSO:CONSO00038) increases bp(GO:"microglial cell activation") |
| pubmed:21718217 | act(a(CONSO:CONSO00038)) increases bp(GO:phagocytosis) |
| pubmed:28019679 | a(CONSO:CONSO00038) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:24561250 | a(CONSO:CONSO00038) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:21718217 | a(CONSO:CONSO00022) decreases bp(GO:"synaptic signaling") |
| pubmed:21718217 | a(CONSO:CONSO00022) increases bp(GO:"neuron death") |
| pubmed:21214928 | complex(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) decreases p(CONSO:CONSO00069) |
| pubmed:22110360 | act(p(HGNC:DNM1)) increases bp(GO:endocytosis) |
| pubmed:22110360 | act(p(HGNC:DNM1)) increases bp(GO:"synaptic vesicle budding from endosome") |
| pubmed:30515821 | act(p(HGNC:DNM1)) increases path(DOID:"Parkinson's disease") |
| pubmed:30515821 | p(HGNC:DNM1) increases path(DOID:"Parkinson's disease") |
| pubmed:30515821 | p(HGNC:DNM1) decreases path(MESH:Neuroprotection) |
| pubmed:30515821 | p(HGNC:DNM1) increases bp(GO:"programmed cell death") |
| pubmed:30515821 | p(HGNC:DNM1) negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | p(HGNC:DNM1) negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | act(p(HGNC:DNM1), ma(GO:"GTPase activity")) increases a(MESH:Mitochondria) |
| pubmed:30515821 | p(HGNC:DNM1) causesNoChange a(MESH:Mitochondria, loc(GO:"synaptic vesicle")) |
| pubmed:30515821 | p(HGNC:DNM1) positiveCorrelation path(OMIT:0010462) |
| pubmed:30515821 | p(HGNC:DNM1) positiveCorrelation bp(GO:memory) |
| pubmed:30515821 | p(HGNC:DNM1) decreases bp(GO:"neuron death") |
| pubmed:30515821 | p(HGNC:DNM1) increases tloc(a(CHEBI:ATP), fromLoc(GO:mitochondrion), toLoc(GO:"axon cytoplasm")) |
| pubmed:30515821 | p(HGNC:DNM1) positiveCorrelation bp(GO:"synaptic vesicle cycle") |
| pubmed:30515821 | p(HGNC:DNM1) increases a(OMIT:0012627) |
| pubmed:30515821 | p(HGNC:DNM1) decreases path(OMIT:0002643) |
| pubmed:30515821 | p(HGNC:DNM1) positiveCorrelation bp(GO:"motor behavior") |
| pubmed:30515821 | p(HGNC:DNM1) decreases bp(GO:"mitochondrial fusion") |
| pubmed:30515821 | p(HGNC:DNM1) increases bp(GO:mitophagy) |
| pubmed:30515821 | p(HGNC:DNM1) positiveCorrelation bp(GO:"oxidative phosphorylation") |
| pubmed:30515821 | act(p(HGNC:DNM1)) increases path(DOID:"neurodegenerative disease") |
| pubmed:30515821 | p(HGNC:DNM1) decreases a(GO:synapse) |
| pubmed:30515821 | p(HGNC:DNM1) increases bp(GO:"inflammatory response") |
| pubmed:30515821 | p(HGNC:DNM1) increases a(OMIT:0016987) |
| pubmed:30515821 | p(HGNC:DNM1) positiveCorrelation bp(GO:"immunological synapse formation") |
| pubmed:30515821 | p(HGNC:DNM1) increases a(CHEBI:"hydrogen peroxide") |
| pubmed:30515821 | p(HGNC:DNM1) increases bp(OMIT:0016017) |
| pubmed:30515821 | p(HGNC:DNM1) increases a(CHEBI:amyloid-beta) |
| pubmed:30515821 | p(HGNC:DNM1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30515821 | act(p(HGNC:DNM1)) increases bp(GO:"mitochondrial fission") |
| pubmed:19721446 | p(HGNC:DNM1) association p(HGNC:CHRNB2) |
| pubmed:29590627 | act(p(HGNC:DNM1)) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:29590627 | act(p(HGNC:DNM1)) increases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:29590627 | act(p(HGNC:DNM1)) increases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:21214928 | a(MESH:"Potassium Channels") association a(CHEBI:amyloid-beta) |
| pubmed:21214928 | complex(p(HGNC:APBA1), p(HGNC:APP)) regulates bp(GO:"protein transport") |
| pubmed:21214928 | complex(p(HGNC:APBA1), p(HGNC:APP)) association p(CONSO:CONSO00067) |
| pubmed:21214928 | complex(p(HGNC:APBA1), p(HGNC:APP)) association tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21214928 | complex(p(HGNC:APBA1), p(HGNC:APP)) association a(CHEBI:amyloid-beta) |
| pubmed:21214928 | complex(p(HGNC:APBA1), p(HGNC:APP)) association tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21214928 | complex(p(HGNC:APBA2), p(HGNC:APP)) regulates bp(GO:"protein transport") |
| pubmed:21214928 | complex(p(HGNC:APBA2), p(HGNC:APP)) association p(CONSO:CONSO00067) |
| pubmed:21214928 | complex(p(HGNC:APBA2), p(HGNC:APP)) association tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21214928 | complex(p(HGNC:APBA2), p(HGNC:APP)) association a(CHEBI:amyloid-beta) |
| pubmed:21214928 | complex(p(HGNC:APBA2), p(HGNC:APP)) association tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21214928 | complex(p(HGNC:APBA3), p(HGNC:APP)) regulates bp(GO:"protein transport") |
| pubmed:21214928 | complex(p(HGNC:APBA3), p(HGNC:APP)) association p(CONSO:CONSO00067) |
| pubmed:21214928 | complex(p(HGNC:APBA3), p(HGNC:APP)) association tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21214928 | complex(p(HGNC:APBA3), p(HGNC:APP)) association a(CHEBI:amyloid-beta) |
| pubmed:21214928 | complex(p(HGNC:APBA3), p(HGNC:APP)) association tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21214928 | p(HGNC:RAB6A) association bp(CONSO:CONSO00073) |
| pubmed:21214928 | bp(GO:"clathrin-dependent endocytosis") increases deg(p(HGNC:APP)) |
| pubmed:30027901 | bp(GO:"clathrin-dependent endocytosis") association p(HGNC:HTT) |
| pubmed:26751493 | bp(GO:"clathrin-dependent endocytosis") positiveCorrelation p(HGNC:MAPT) |
| pubmed:26751493 | bp(GO:"clathrin-dependent endocytosis") isA tloc(a(CONSO:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) |
| pubmed:27260836 | bp(GO:"clathrin-dependent endocytosis") positiveCorrelation complex(p(CONSO:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) |
| pubmed:26751493 | bp(GO:"clathrin-dependent endocytosis") association p(CONSO:"Tau oligomers") |
| pubmed:21214928 | complex(p(HGNC:PLD1), p(HGNC:PSEN1)) increases p(HGNC:APP) |
| pubmed:21214928 | complex(p(HGNC:APP), p(HGNC:LRP1)) increases a(CHEBI:amyloid-beta) |
| pubmed:21214928 | complex(p(HGNC:APP), p(HGNC:LRP1)) decreases p(HGNC:APP) |
| pubmed:21214928 | complex(p(HGNC:APP), p(HGNC:LRP1B)) decreases a(CHEBI:amyloid-beta) |
| pubmed:21214928 | complex(p(HGNC:APP), p(HGNC:LRP1B)) increases tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21214928 | a(CHEBI:estrogen) decreases a(CHEBI:amyloid-beta) |
| pubmed:19293145 | a(CHEBI:estrogen) decreases act(a(CHEBI:amyloid-beta)) |
| pubmed:11230871 | a(CHEBI:estrogen) decreases act(a(CHEBI:amyloid-beta)) |
| pubmed:21214928 | a(CHEBI:estrogen) increases tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:19293145 | a(CHEBI:estrogen) decreases act(g(CONSO:"APOE e4")) |
| pubmed:11230871 | a(CHEBI:estrogen) decreases path(MESH:"Alzheimer Disease") |
| pubmed:21214928 | act(p(HGNC:PRKCA)) increases tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21214928 | p(HGNC:PRKCA) increases tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21214928 | p(HGNC:PRKCA) decreases a(CHEBI:amyloid-beta) |
| pubmed:21214928 | p(HGNC:PRKCA) directlyIncreases p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation", Ser, 655)) |
| pubmed:22122372 | p(HGNC:PRKCA) increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 654)) |
| pubmed:22122372 | p(HGNC:PRKCA) increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) |
| pubmed:22122372 | p(HGNC:PRKCA) increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Ser, 665)) |
| pubmed:21214928 | p(HGNC:RAB11A) decreases a(CHEBI:amyloid-beta) |
| pubmed:30027901 | p(HGNC:RAB11A) increases bp(GO:"synaptic vesicle recycling via endosome") |
| pubmed:27181519 | p(HGNC:RAB11A) association g(HGNC:C9orf72) |
| pubmed:22122372 | p(CONSO:CONSO00078) association p(HGNC:APP) |
| pubmed:22122372 | p(CONSO:CONSO00078) increases complex(p(HGNC:APP), p(HGNC:APP)) |
| pubmed:22122372 | p(CONSO:CONSO00078) increases complex(p(HGNC:APLP1), p(HGNC:APLP1)) |
| pubmed:22122372 | p(CONSO:CONSO00078) increases complex(p(HGNC:APLP2), p(HGNC:APLP2)) |
| pubmed:22122372 | p(CONSO:CONSO00079) association p(HGNC:APP) |
| pubmed:22908190 | complex(p(HGNC:APP), p(HGNC:APP)) increases bp(GO:endocytosis) |
| pubmed:22122372 | composite(p(MGI:Aplp1), p(MGI:Aplp2), p(MGI:App)) decreases path(MESH:"Perinatal Death") |
| pubmed:22122372 | p(HGNC:PSEN1, var("?")) increases p(HGNC:APP, frag("672_713")) |
| pubmed:21722302 | p(HGNC:PSEN1, var("?")) increases p(HGNC:APP, frag("672_713")) |
| pubmed:30688256 | p(HGNC:PSEN1, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | p(HGNC:PSEN1, var("?")) association path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | p(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer Disease") |
| pubmed:30688256 | p(HGNC:PSEN1, var("?")) decreases bp(GO:autophagy) |
| pubmed:30688256 | p(HGNC:PSEN1, var("?")) decreases act(a(MESH:Mitochondria)) |
| pubmed:30688256 | p(HGNC:PSEN1, var("?")) decreases path(GO:mitophagy) |
| pubmed:21722302 | p(HGNC:PSEN1, var("?")) increases bp(MESH:Apoptosis) |
| pubmed:21722302 | p(HGNC:PSEN1, var("?")) decreases p(HGNC:ERN1) |
| pubmed:21722302 | p(HGNC:PSEN1, var("?")) decreases r(HGNC:HSPA5) |
| pubmed:21722302 | p(HGNC:PSEN1, var("?")) decreases r(HGNC:XBP1) |
| pubmed:21722302 | p(HGNC:PSEN1, var("?")) decreases bp(GO:"calcium ion homeostasis") |
| pubmed:21722302 | p(HGNC:PSEN1, var("?")) increases tloc(a(CHEBI:"calcium cation"), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:cytoplasm)) |
| pubmed:26968346 | p(HGNC:PSEN1, var("?")) decreases p(HGNCGENEFAMILY:"V-type ATPases") |
| pubmed:26968346 | p(HGNC:PSEN1, var("?")) negativeCorrelation bp(GO:"proton-transporting V-type ATPase complex assembly") |
| pubmed:29758300 | p(HGNC:PSEN1, var("?")) decreases act(a(MESH:"Vacuolar Proton-Translocating ATPases")) |
| pubmed:14556719 | p(HGNC:PSEN1, var("?")) association act(complex(GO:"gamma-secretase complex")) |
| pubmed:14556719 | p(HGNC:PSEN1, var("?")) increases a(CHEBI:amyloid-beta) |
| pubmed:22908190 | p(HGNC:PSEN1, var("?")) decreases bp(GO:"lysosomal protein catabolic process") |
| pubmed:22908190 | p(HGNC:PSEN1, var("?")) decreases act(a(CONSO:Neurites)) |
| pubmed:22908190 | p(HGNC:PSEN1, var("?")) decreases bp(GO:"pH reduction") |
| pubmed:22908190 | p(HGNC:PSEN1, var("?")) decreases act(a(MESH:Neurites)) |
| pubmed:24027553 | p(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer disease, familial, type 3") |
| pubmed:22122372 | p(HGNC:PSEN2, var("?")) increases p(HGNC:APP, frag("672_713")) |
| pubmed:14556719 | p(HGNC:PSEN2, var("?")) association act(complex(GO:"gamma-secretase complex")) |
| pubmed:14556719 | p(HGNC:PSEN2, var("?")) increases a(CHEBI:amyloid-beta) |
| pubmed:22122372 | a(MESH:"Receptors, Cell Surface") association p(HGNC:APP) |
| pubmed:22122372 | complex(p(HGNC:APP), p(HGNC:RTN4R)) regulates bp(CONSO:CONSO00073) |
| pubmed:22122372 | complex(p(HGNC:APP), p(HGNC:ITM2B)) regulates bp(CONSO:CONSO00073) |
| pubmed:22122372 | complex(p(CONSO:CONSO00078), p(CONSO:CONSO00079)) increases complex(p(HGNC:APLP1), p(HGNC:APP)) |
| pubmed:22122372 | complex(p(CONSO:CONSO00078), p(CONSO:CONSO00079)) increases complex(p(HGNC:APLP2), p(HGNC:APP)) |
| pubmed:22122372 | complex(p(CONSO:CONSO00078), p(CONSO:CONSO00079)) increases complex(p(HGNC:APP), p(HGNC:APP)) |
| pubmed:22122372 | complex(p(CONSO:CONSO00042, frag("?")), p(HGNC:TNFRSF21)) increases bp(GO:"neuron death") |
| pubmed:22122372 | complex(p(CONSO:CONSO00042, frag("?")), p(HGNC:TNFRSF21)) increases bp(GO:"synapse pruning") |
| pubmed:12428809 | p(HGNC:KLC1) increases bp(GO:"anterograde axonal transport") |
| pubmed:19491104 | act(p(HGNC:KLC1)) positiveCorrelation act(complex(GO:"kinesin complex")) |
| pubmed:19491104 | p(HGNC:KLC1) isA complex(GO:"kinesin complex") |
| pubmed:19491104 | p(HGNC:KLC1) association p(HGNC:MAPK8IP1) |
| pubmed:22122372 | complex(p(CONSO:CONSO00071), p(HGNC:APBA1)) decreases a(CHEBI:amyloid-beta) |
| pubmed:22122372 | p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 654)) association bp(CONSO:CONSO00073) |
| pubmed:22122372 | p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 654)) association act(p(CONSO:CONSO00071)) |
| pubmed:22122372 | p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) association bp(CONSO:CONSO00073) |
| pubmed:22122372 | p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) association act(p(CONSO:CONSO00071)) |
| pubmed:22122372 | p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Ser, 665)) association bp(CONSO:CONSO00073) |
| pubmed:22122372 | p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Ser, 665)) association act(p(CONSO:CONSO00071)) |
| pubmed:22122372 | a(MESH:"JNK Mitogen-Activated Protein Kinases") increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 654)) |
| pubmed:22122372 | a(MESH:"JNK Mitogen-Activated Protein Kinases") increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) |
| pubmed:22122372 | a(MESH:"JNK Mitogen-Activated Protein Kinases") increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Ser, 665)) |
| pubmed:22122372 | complex(p(CONSO:CONSO00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:CD82) |
| pubmed:22122372 | complex(p(CONSO:CONSO00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:MME) |
| pubmed:22122372 | complex(p(CONSO:CONSO00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:TP53) |
| pubmed:22122372 | complex(p(CONSO:CONSO00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:GSK3B) |
| pubmed:22122372 | complex(p(CONSO:CONSO00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:EGFR) |
| pubmed:22122372 | complex(p(CONSO:CONSO00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:LRP1) |
| pubmed:21034527 | p(HGNC:KAT5) isA p(INTERPRO:"Histone acetyltransferase domain, MYST-type") |
| pubmed:22122372 | act(p(HGNC:TP53)) increases bp(GO:"apoptotic process") |
| pubmed:26293599 | p(HGNC:TP53) association p(HGNC:BTG2) |
| pubmed:22122372 | complex(p(CONSO:CONSO00071), p(HGNC:APBB1), p(HGNC:TFCP2)) increases p(HGNC:GSK3B) |
| pubmed:22122372 | complex(p(CONSO:CONSO00071), p(HGNC:MAPK8IP1)) regulates p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) |
| pubmed:22122372 | complex(p(CONSO:CONSO00071), p(HGNC:MAPK8IP1)) association bp(CONSO:CONSO00073) |
| pubmed:19491104 | act(p(HGNC:MAPK8IP1)) positiveCorrelation act(complex(GO:"kinesin complex")) |
| pubmed:19491104 | p(HGNC:MAPK8IP1) isA complex(GO:"kinesin complex") |
| pubmed:19491104 | p(HGNC:MAPK8IP1) association p(HGNC:KLC1) |
| pubmed:21034527 | p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) increases complex(p(HGNC:APBB1), p(INTERPRO:"Amyloidogenic glycoprotein, intracellular domain, conserved site")) |
| pubmed:27094130 | p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) association bp(CONSO:"APP processing") |
| pubmed:27094130 | p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) regulates tloc(p(HGNC:APP, frag("672_711")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27094130 | p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) regulates tloc(p(HGNC:APP, frag("672_713")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:22122372 | complex(p(CONSO:CONSO00071), p(HGNC:NAE1)) increases bp(GO:"protein neddylation") |
| pubmed:22122372 | complex(p(CONSO:CONSO00071), p(HGNC:NAE1)) decreases p(HGNC:CTNNB1) |
| pubmed:22122372 | complex(p(CONSO:CONSO00071), p(HGNC:NAE1)) increases bp(GO:"apoptotic process") |
| url:"https://www.ncbi.nlm.nih.gov/clinvar/RCV000019448/" | g(HGNC:APOE, var("c.388T>C")) equivalentTo g(DBSNP:rs429358) |
| url:"https://www.ncbi.nlm.nih.gov/clinvar/RCV000019448/" | g(HGNC:APOE, var("c.388T>C")) transcribedTo r(HGNC:APOE, var("r.388u>c")) |
| pubmed:19734902 | g(HGNC:APOE) association path(MESH:"Alzheimer Disease") |
| pubmed:19734903 | g(HGNC:APOE) association path(MESH:"Alzheimer Disease") |
| pubmed:20460622 | g(HGNC:APOE) association path(MESH:"Alzheimer Disease") |
| pubmed:20885792 | g(HGNC:APOE) association path(MESH:"Alzheimer Disease") |
| pubmed:17474819 | g(HGNC:APOE) association path(MESH:"Alzheimer Disease") |
| pubmed:21123754 | g(HGNC:APOE) association path(MESH:"Alzheimer Disease") |
| pubmed:10936883 | g(HGNC:APOE) association path(MESH:"Alzheimer Disease") |
| pubmed:19293145 | g(HGNC:APOE) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(HGNC:APOE) association g(DBSNP:rs2075650) |
| pubmed:20460622 | g(HGNC:APOE) association g(DBSNP:rs2075650) |
| pubmed:20885792 | g(HGNC:APOE) association g(DBSNP:rs2075650) |
| pubmed:19734903 | g(HGNC:APOE) association g(DBSNP:rs11136000) |
| pubmed:17474819 | g(HGNC:APOE) association g(DBSNP:rs4420638) |
| pubmed:21123754 | g(HGNC:APOE) association g(DBSNP:rs429358) |
| pubmed:21123754 | g(HGNC:APOE) association g(DBSNP:rs429358) |
| pubmed:23419831 | g(HGNC:APOE) association g(DBSNP:rs429358) |
| pubmed:21123754 | g(HGNC:APOE) association g(DBSNP:rs439401) |
| pubmed:23562540 | g(HGNC:APOE) association g(DBSNP:rs769449) |
| pubmed:19293145 | g(HGNC:APOE) increases p(HGNC:APOE) |
| pubmed:19293145 | g(HGNC:APOE) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19293145 | g(HGNC:APOE) negativeCorrelation p(HGNC:CHAT) |
| pubmed:19293145 | g(HGNC:APOE) negativeCorrelation act(a(CHEBI:tacrine)) |
| pubmed:19293145 | g(HGNC:APOE) causesNoChange complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| pubmed:31413141 | g(HGNC:APOE) negativeCorrelation a(CHEBI:"amyloid-beta polypeptide 42") |
| url:"https://www.ncbi.nlm.nih.gov/clinvar/RCV000019448/" | g(DBSNP:rs429358) equivalentTo g(HGNC:APOE, var("c.388T>C")) |
| pubmed:21123754 | g(DBSNP:rs429358) association path(MESH:"Alzheimer Disease") |
| pubmed:21123754 | g(DBSNP:rs429358) association g(HGNC:APOE) |
| pubmed:21123754 | g(DBSNP:rs429358) association g(HGNC:APOE) |
| pubmed:23419831 | g(DBSNP:rs429358) association g(HGNC:APOE) |
| url:"https://www.ncbi.nlm.nih.gov/clinvar/RCV000019448/" | r(HGNC:APOE, var("r.388u>c")) translatedTo p(HGNC:APOE, var("p.Cys130Arg")) |
| pubmed:19940480 | p(HGNC:APOE, var("p.Cys130Arg")) positiveCorrelation a(NIFT:"Brain volume") |
| pubmed:19940480 | p(HGNC:APOE, var("p.Cys130Arg")) negativeCorrelation a(NIFT:"Hippocampus volume") |
| pubmed:19940480 | p(HGNC:APOE, var("p.Cys130Arg")) negativeCorrelation a(NIFT:"Ventricular volume") |
| pubmed:21460840 | g(HGNC:CR1) association g(DBSNP:rs3818361) |
| pubmed:19734903 | g(HGNC:CR1) association g(DBSNP:rs3818361) |
| pubmed:21460841 | g(HGNC:CR1) association path(MESH:"Alzheimer Disease") |
| pubmed:21460841 | g(HGNC:CR1) association g(DBSNP:rs6701713) |
| pubmed:21460841 | g(HGNC:CR1) association g(DBSNP:rs6701713) |
| pubmed:24162737 | g(HGNC:CR1) association g(DBSNP:rs6656401) |
| pubmed:19734903 | g(HGNC:CR1) association g(DBSNP:rs6656401) |
| pubmed:" 26517285" | g(HGNC:CR1) association bp(GO:"immune response") |
| pubmed:22244847 | g(DBSNP:rs3818361) increases bp(GO:"long-term synaptic depression") |
| pubmed:23022416 | g(DBSNP:rs3818361) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23022416 | g(DBSNP:rs3818361) negativeCorrelation p(HGNC:APP, frag("672_713")) |
| pubmed:21460840 | g(DBSNP:rs3818361) association g(HGNC:CR1) |
| pubmed:19734903 | g(DBSNP:rs3818361) association g(HGNC:CR1) |
| pubmed:25468261 | a(CONSO:"CDR - Sum of Boxes") positiveCorrelation p(HGNC:APP, frag("672_713")) |
| pubmed:25468261 | a(CONSO:"CDR - Sum of Boxes") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23727081 | a(CONSO:"CDR - Sum of Boxes") positiveCorrelation composite(g(DBSNP:rs1868402), g(DBSNP:rs3785883)) |
| pubmed:23138174 | a(CONSO:"CDR - Sum of Boxes") positiveCorrelation a(NIFT:"Alzheimer questionnaire") |
| pubmed:16254429 | a(CONSO:"CDR - Sum of Boxes") positiveCorrelation a(NIFT:"Clinical dementia rating") |
| pubmed:25429309 | a(CONSO:"CDR - Sum of Boxes") positiveCorrelation a(NIFT:"Dopamine transporter scan") |
| pubmed:23175194 | a(CONSO:"CDR - Sum of Boxes") negativeCorrelation a(NIFT:"Hippocampus volume") |
| pubmed:26043140 | a(CONSO:"CDR - Sum of Boxes") association a(EFO:"cognitive decline measurement") |
| pubmed:25542982 | a(CONSO:"CDR - Sum of Boxes") negativeCorrelation a(NIFT:"3-HPMA/Cre ratio") |
| pubmed:24242746 | a(CONSO:"CDR - Sum of Boxes") positiveCorrelation p(HGNC:NEFL) |
| pubmed:25429309 | a(CONSO:"CDR - Sum of Boxes") negativeCorrelation p(HGNC:SLC6A3) |
| pubmed:23775979 | a(CONSO:"CDR - Sum of Boxes") negativeCorrelation complex(a(InChI:"InChI=1S/C22H21NO3/c1-17(24)23(16-18-10-6-8-14-21(18)25-2)20-13-7-9-15-22(20)26-19-11-4-3-5-12-19/h3-15H,16H2,1-2H3/i2-1"), p(HGNC:TSPO)) |
| pubmed:25566378 | a(CONSO:"CDR - Sum of Boxes") negativeCorrelation path(GO:"short-term memory") |
| pubmed:18346821 | a(CONSO:"CDR - Sum of Boxes") positiveCorrelation a(MESH:"2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole") |
| pubmed:25024322 | a(CONSO:"CDR - Sum of Boxes") positiveCorrelation p(HGNC:CHI3L1) |
| pubmed:23727081 | composite(g(DBSNP:rs1868402), g(DBSNP:rs3785883)) positiveCorrelation a(CONSO:"CDR - Sum of Boxes") |
| pubmed:23727081 | g(DBSNP:rs1868402) causesNoChange a(CONSO:"CDR - Sum of Boxes") |
| pubmed:23727081 | g(DBSNP:rs3785883) causesNoChange a(CONSO:"CDR - Sum of Boxes") |
| pubmed:27084223 | a(NIFT:"Fractional anisotropy") negativeCorrelation a(NIFT:"Clinical dementia rating") |
| pubmed:21543606 | a(NIFT:"Fractional anisotropy") decreases a(NIFT:"White matter") |
| pubmed:21543606 | a(NIFT:"Fractional anisotropy") association bp(GO:"regulation of lipid metabolic process") |
| pubmed:27084223 | a(NIFT:"Clinical dementia rating") negativeCorrelation a(NIFT:"Fractional anisotropy") |
| pubmed:25207744 | a(NIFT:"Clinical dementia rating") positiveCorrelation a(NIFT:"Heidelberg edge perimetry") |
| pubmed:26682680 | a(NIFT:"Clinical dementia rating") positiveCorrelation path(MESH:Hallucinations) |
| pubmed:25304332 | a(NIFT:"Clinical dementia rating") positiveCorrelation p(HGNC:SERPINE1) |
| pubmed:23567436 | a(NIFT:"Clinical dementia rating") positiveCorrelation g(DBSNP:rs3853248) |
| pubmed:23567436 | a(NIFT:"Clinical dementia rating") positiveCorrelation g(DBSNP:rs22334693) |
| pubmed:23567436 | a(NIFT:"Clinical dementia rating") positiveCorrelation g(DBSNP:rs9340799) |
| pubmed:23567436 | a(NIFT:"Clinical dementia rating") positiveCorrelation g(DBSNP:rs9397456) |
| pubmed:23567436 | a(NIFT:"Clinical dementia rating") positiveCorrelation g(DBSNP:rs1801132) |
| pubmed:23567436 | a(NIFT:"Clinical dementia rating") positiveCorrelation g(DBSNP:rs2179922) |
| pubmed:23567436 | a(NIFT:"Clinical dementia rating") positiveCorrelation g(DBSNP:rs932477) |
| pubmed:23567436 | a(NIFT:"Clinical dementia rating") positiveCorrelation g(DBSNP:rs9341016) |
| pubmed:16254429 | a(NIFT:"Clinical dementia rating") positiveCorrelation a(CONSO:"CDR - Sum of Boxes") |
| pubmed:25116835 | a(NIFT:"Clinical dementia rating") negativeCorrelation p(HGNC:DYRK1A) |
| pubmed:24961945 | a(NIFT:"Clinical dementia rating") positiveCorrelation a(CHEBI:"manganese(2+)") |
| pubmed:25678559 | a(NIFT:"Clinical dementia rating") positiveCorrelation p(HGNC:APP) |
| pubmed:27018940 | p(HGNC:NRGN) positiveCorrelation a(NIFT:"Brain atrophy") |
| pubmed:27018940 | a(NIFT:"Brain atrophy") positiveCorrelation p(HGNC:NRGN) |
| pubmed:23092889 | p(HGNC:MAPK1) association p(HGNC:EIF2AK2) |
| pubmed:30515821 | p(HGNC:MAPK1) increases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) |
| pubmed:30515821 | p(HGNC:MAPK1) association path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | p(HGNC:MAPK1) association path(DOID:"neurodegenerative disease") |
| pubmed:19126755 | act(p(HGNC:MAPK1)) association bp(MESH:"Neuronal Plasticity") |
| pubmed:22530628 | p(HGNC:MAPK1) increases bp(MESH:"Neuronal Plasticity") |
| pubmed:19126755 | act(p(HGNC:MAPK1)) association path(MESH:"Tobacco Use Disorder") |
| pubmed:19293145 | act(p(HGNC:MAPK1)) increases bp(GO:"apoptotic process") |
| pubmed:22530628 | p(HGNC:MAPK1) increases bp(GO:cognition) |
| pubmed:22530628 | p(HGNC:MAPK1) increases bp(GO:"learning or memory") |
| pubmed:22530628 | act(p(HGNC:MAPK1)) increases p(HGNC:ARC) |
| pubmed:22530628 | p(HGNC:MAPK1) increases p(HGNC:ARC) |
| pubmed:26968346 | act(p(HGNC:MAPK1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 142)) |
| pubmed:27299292 | act(p(HGNC:MAPK1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 142)) |
| pubmed:27299292 | act(p(HGNC:MAPK1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 142)) |
| pubmed:26968346 | act(p(HGNC:MAPK1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 211)) |
| pubmed:27299292 | act(p(HGNC:MAPK1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:TFEB, loc(GO:cytoplasm)) |
| pubmed:28784767 | act(p(HGNC:MAPK1)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:28784767 | act(p(HGNC:MAPK1)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:25207744 | a(NIFT:"Heidelberg edge perimetry") positiveCorrelation a(NIFT:"Clinical dementia rating") |
| pubmed:25171717 | p(HGNC:MAPT, frag("421_*")) causesNoChange a(CONSO:"CDR - Sum of Boxes") |
| pubmed:25171717 | p(HGNC:MAPT, frag("421_*")) causesNoChange a(NIFT:"Mini mental state exam") |
| pubmed:25171717 | p(HGNC:MAPT, frag("421_*")) causesNoChange a(NIFT:"Alzheimers disease assessment scale") |
| pubmed:25171717 | p(HGNC:MAPT, frag("152_*")) causesNoChange a(CONSO:"CDR - Sum of Boxes") |
| pubmed:25171717 | p(HGNC:MAPT, frag("152_*")) causesNoChange a(NIFT:"Mini mental state exam") |
| pubmed:25171717 | p(HGNC:MAPT, frag("152_*")) causesNoChange a(NIFT:"Alzheimers disease assessment scale") |
| pubmed:26682680 | a(NIFT:"Mini mental state exam") positiveCorrelation path(MESH:Hallucinations) |
| pubmed:25304332 | a(NIFT:"Mini mental state exam") positiveCorrelation p(HGNC:SERPINE1) |
| pubmed:24961945 | a(NIFT:"Mini mental state exam") positiveCorrelation a(CHEBI:"manganese(2+)") |
| pubmed:25542982 | a(NIFT:"Mini mental state exam") negativeCorrelation a(NIFT:"3-HPMA/Cre ratio") |
| pubmed:23775979 | a(NIFT:"Mini mental state exam") negativeCorrelation complex(a(InChI:"InChI=1S/C22H21NO3/c1-17(24)23(16-18-10-6-8-14-21(18)25-2)20-13-7-9-15-22(20)26-19-11-4-3-5-12-19/h3-15H,16H2,1-2H3/i2-1"), p(HGNC:TSPO)) |
| pubmed:25566378 | a(NIFT:"Mini mental state exam") positiveCorrelation path(GO:"short-term memory") |
| pubmed:21504134 | a(NIFT:"Mini mental state exam") positiveCorrelation a(NIFT:"Cortical Thinning") |
| pubmed:25678559 | a(NIFT:"Mini mental state exam") negativeCorrelation p(HGNC:APP) |
| pubmed:10449594 | a(NIFT:"Mini mental state exam") positiveCorrelation a(NIFT:Hypoperfusion) |
| pubmed:26682680 | path(MESH:Hallucinations) positiveCorrelation a(NIFT:"Clinical dementia rating") |
| pubmed:26682680 | path(MESH:Hallucinations) positiveCorrelation a(NIFT:"Mini mental state exam") |
| pubmed:30061532 | path(MESH:Hallucinations) negativeCorrelation bp(GO:autophagy) |
| pubmed:24511233 | path(MESH:Hallucinations) association path(MESH:Schizophrenia) |
| pubmed:24511233 | path(MESH:Hallucinations) biomarkerFor path(MESH:Schizophrenia) |
| pubmed:19721446 | path(MESH:Hallucinations) association path(MESH:Schizophrenia) |
| pubmed:25304332 | p(HGNC:SERPINE1) positiveCorrelation a(NIFT:"Clinical dementia rating") |
| pubmed:25304332 | p(HGNC:SERPINE1) positiveCorrelation a(NIFT:"Mini mental state exam") |
| pubmed:23138174 | a(NIFT:"Alzheimer questionnaire") positiveCorrelation a(CONSO:"CDR - Sum of Boxes") |
| pubmed:25570489 | p(HGNC:ESR1) association a(NIFT:"Ventricular expansion") |
| pubmed:25570489 | p(HGNC:ESR1) association a(NIFT:"Hippocampal atrophy") |
| pubmed:26837465 | p(HGNC:ESR1) association complex(GO:"neurofibrillary tangle") |
| pubmed:26837465 | p(HGNC:ESR1) association complex(GO:"neurofibrillary tangle") |
| pubmed:23567436 | g(DBSNP:rs3853248) positiveCorrelation a(NIFT:"Clinical dementia rating") |
| pubmed:23567436 | g(DBSNP:rs22334693) positiveCorrelation a(NIFT:"Clinical dementia rating") |
| pubmed:23567436 | g(DBSNP:rs9340799) positiveCorrelation a(NIFT:"Clinical dementia rating") |
| pubmed:23567436 | g(DBSNP:rs9397456) positiveCorrelation a(NIFT:"Clinical dementia rating") |
| pubmed:23567436 | g(DBSNP:rs1801132) positiveCorrelation a(NIFT:"Clinical dementia rating") |
| pubmed:23567436 | g(DBSNP:rs2179922) positiveCorrelation a(NIFT:"Clinical dementia rating") |
| pubmed:23567436 | g(DBSNP:rs932477) positiveCorrelation a(NIFT:"Clinical dementia rating") |
| pubmed:23567436 | g(DBSNP:rs9341016) positiveCorrelation a(NIFT:"Clinical dementia rating") |
| pubmed:22701578 | a(NIFT:"Rey auditory verbal learning test") negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22701578 | a(NIFT:"Rey auditory verbal learning test") negativeCorrelation a(NIFT:"Ratio phospho tau to abeta 42 test") |
| pubmed:22701578 | a(NIFT:"Ratio phospho tau to abeta 42 test") negativeCorrelation a(NIFT:"Rey auditory verbal learning test") |
| pubmed:25429309 | a(NIFT:"Dopamine transporter scan") positiveCorrelation a(CONSO:"CDR - Sum of Boxes") |
| pubmed:25116835 | p(HGNC:DYRK1A) negativeCorrelation a(NIFT:"Clinical dementia rating") |
| pubmed:25116835 | p(HGNC:DYRK1A) negativeCorrelation p(HGNC:MAPT) |
| pubmed:22110360 | p(HGNC:DYRK1A) association p(HGNC:MAPT) |
| pubmed:25116835 | p(HGNC:DYRK1A) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22110360 | p(HGNC:DYRK1A) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22110360 | p(HGNC:DYRK1A) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25116835 | p(HGNC:DYRK1A) causesNoChange p(HGNC:APP, frag("672_713")) |
| pubmed:21156028 | p(HGNC:DYRK1A) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) |
| pubmed:21156028 | p(HGNC:DYRK1A) increases p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation", Thr, 688)) |
| pubmed:22110360 | p(HGNC:DYRK1A) increases p(FPLX:NFAT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22110360 | p(HGNC:DYRK1A) increases p(FPLX:CREB, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22110360 | act(p(HGNC:DYRK1A)) increases p(FPLX:CREB, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22110360 | p(HGNC:DYRK1A) increases p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22110360 | p(HGNC:DYRK1A) increases p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22110360 | p(HGNC:DYRK1A) increases p(HGNC:SNCA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22110360 | p(HGNC:DYRK1A) increases p(HGNC:SNCA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22110360 | p(HGNC:DYRK1A) increases p(HGNC:SNCA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22110360 | p(HGNC:DYRK1A) increases act(p(FPLX:NFAT), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:22110360 | p(HGNC:DYRK1A) increases act(p(FPLX:FOXO), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:22110360 | p(HGNC:DYRK1A) increases act(p(HGNC:DNM1)) |
| pubmed:22110360 | p(HGNC:DYRK1A) increases act(p(HGNC:AMPH)) |
| pubmed:22110360 | p(HGNC:DYRK1A) association p(HGNC:APP) |
| pubmed:22110360 | p(HGNC:DYRK1A) association path(MESH:"Alzheimer Disease") |
| pubmed:28632203 | p(HGNC:DYRK1A) biomarkerFor path(MESH:"Alzheimer Disease") |
| pubmed:22110360 | p(HGNC:DYRK1A) increases act(p(FPLX:JNK)) |
| pubmed:22110360 | p(HGNC:DYRK1A) increases act(p(HGNC:MAP3K5)) |
| pubmed:22110360 | p(HGNC:DYRK1A) increases bp(GO:"apoptotic process") |
| pubmed:22110360 | act(p(HGNC:DYRK1A)) increases bp(GO:"apoptotic process") |
| pubmed:22110360 | act(p(HGNC:DYRK1A)) association bp(GO:"cell population proliferation") |
| pubmed:22110360 | act(p(HGNC:DYRK1A)) increases act(p(FPLX:ERK)) |
| pubmed:22110360 | act(p(HGNC:DYRK1A)) increases complex(p(FPLX:MEK), p(FPLX:RAF), p(FPLX:RAS)) |
| pubmed:28137862 | p(HGNC:DYRK1A) association path(MESH:"Down Syndrome") |
| pubmed:28884684 | act(p(HGNC:DYRK1A), ma(go:0016301 ! "kinase activity")) positiveCorrelation bp(GO:"neuron differentiation") |
| pubmed:28250274 | p(HGNC:DYRK1A) negativeCorrelation p(HGNC:MME) |
| pubmed:28167836 | act(p(HGNC:DYRK1A)) regulates a(CONSO:Neurites) |
| pubmed:28167836 | act(p(HGNC:DYRK1A)) regulates a(GO:axon) |
| pubmed:25116835 | p(HGNC:DYRK1B) causesNoChange a(NIFT:"Clinical dementia rating") |
| pubmed:24961945 | a(CHEBI:"manganese(2+)") positiveCorrelation a(NIFT:"Mini mental state exam") |
| pubmed:24961945 | a(CHEBI:"manganese(2+)") positiveCorrelation a(NIFT:"Clinical dementia rating") |
| pubmed:19734902 | g(HGNC:PICALM) association g(DBSNP:rs3851179) |
| pubmed:21379329 | g(HGNC:PICALM) association g(DBSNP:rs3851179) |
| pubmed:19734902 | g(HGNC:PICALM) association g(DBSNP:rs3851179) |
| pubmed:19734902 | g(HGNC:PICALM) association path(MESH:"Alzheimer Disease") |
| pubmed:21627779 | g(HGNC:PICALM) association path(MESH:"Alzheimer Disease") |
| pubmed:21460841 | g(HGNC:PICALM) association path(MESH:"Alzheimer Disease") |
| pubmed:21379329 | g(HGNC:PICALM) association path(MESH:"Alzheimer Disease") |
| pubmed:21627779 | g(HGNC:PICALM) association g(DBSNP:rs536841) |
| pubmed:21627779 | g(HGNC:PICALM) association g(DBSNP:rs536841) |
| pubmed:21460841 | g(HGNC:PICALM) association g(DBSNP:rs5616655) |
| pubmed:24162737 | g(HGNC:PICALM) association g(DBSNP:rs10792832) |
| pubmed:22832961 | g(HGNC:PICALM) association g(DBSNP:rs17817600) |
| pubmed:22005930 | g(HGNC:PICALM) association g(DBSNP:rs10792830) |
| pubmed:21460841 | g(HGNC:PICALM) association g(DBSNP:rs561655) |
| pubmed:" 26517285" | g(HGNC:PICALM) association bp(GO:endocytosis) |
| pubmed:" 26517285" | g(HGNC:PICALM) association bp(GO:"lipid metabolic process") |
| pubmed:25022885 | g(DBSNP:rs3851179) association path(EFO:"late-onset Alzheimers disease") |
| pubmed:19734902 | g(DBSNP:rs3851179) association path(MESH:"Alzheimer Disease") |
| pubmed:21379329 | g(DBSNP:rs3851179) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(DBSNP:rs3851179) association g(HGNC:PICALM) |
| pubmed:21379329 | g(DBSNP:rs3851179) association g(HGNC:PICALM) |
| pubmed:19734902 | g(DBSNP:rs3851179) association g(HGNC:PICALM) |
| pubmed:25022885 | g(DBSNP:rs541458) association path(EFO:"late-onset Alzheimers disease") |
| pubmed:21627779 | g(HGNC:BIN1) association g(DBSNP:rs744373) |
| pubmed:21390209 | g(HGNC:BIN1) association g(DBSNP:rs744373) |
| pubmed:21627779 | g(HGNC:BIN1) association g(DBSNP:rs744373) |
| pubmed:21460840 | g(HGNC:BIN1) association g(DBSNP:rs744373) |
| pubmed:21390209 | g(HGNC:BIN1) association g(DBSNP:rs744373) |
| pubmed:21627779 | g(HGNC:BIN1) association path(MESH:"Alzheimer Disease") |
| pubmed:21460841 | g(HGNC:BIN1) association path(MESH:"Alzheimer Disease") |
| pubmed:21390209 | g(HGNC:BIN1) association path(MESH:"Alzheimer Disease") |
| pubmed:21379329 | g(HGNC:BIN1) association path(MESH:"Alzheimer Disease") |
| pubmed:21460841 | g(HGNC:BIN1) association g(DBSNP:rs7561528) |
| pubmed:21379329 | g(HGNC:BIN1) association g(DBSNP:rs7561528) |
| pubmed:22832961 | g(HGNC:BIN1) association g(DBSNP:rs7561528) |
| pubmed:21460841 | g(HGNC:BIN1) association g(DBSNP:rs7561528) |
| pubmed:21390209 | g(HGNC:BIN1) association g(DBSNP:rs12989701) |
| pubmed:21390209 | g(HGNC:BIN1) association g(DBSNP:rs12989701) |
| pubmed:24162737 | g(HGNC:BIN1) association g(DBSNP:rs6733839) |
| pubmed:22005930 | g(HGNC:BIN1) association g(DBSNP:rs10207628) |
| pubmed:19734902 | g(HGNC:BIN1) association g(DBSNP:rs754107) |
| pubmed:" 26517285" | g(HGNC:BIN1) association bp(GO:endocytosis) |
| pubmed:25022885 | g(DBSNP:rs744373) association path(EFO:"late-onset Alzheimers disease") |
| pubmed:21627779 | g(DBSNP:rs744373) association path(MESH:"Alzheimer Disease") |
| pubmed:21390209 | g(DBSNP:rs744373) association path(MESH:"Alzheimer Disease") |
| pubmed:21627779 | g(DBSNP:rs744373) association g(HGNC:BIN1) |
| pubmed:21390209 | g(DBSNP:rs744373) association g(HGNC:BIN1) |
| pubmed:21627779 | g(DBSNP:rs744373) association g(HGNC:BIN1) |
| pubmed:21460840 | g(DBSNP:rs744373) association g(HGNC:BIN1) |
| pubmed:21390209 | g(DBSNP:rs744373) association g(HGNC:BIN1) |
| pubmed:25022885 | path(EFO:"late-onset Alzheimers disease") association g(DBSNP:rs3851179) |
| pubmed:25022885 | path(EFO:"late-onset Alzheimers disease") association g(DBSNP:rs541458) |
| pubmed:25022885 | path(EFO:"late-onset Alzheimers disease") association g(DBSNP:rs744373) |
| pubmed:17192785 | path(EFO:"late-onset Alzheimers disease") association g(DBSNP:rs4420638) |
| pubmed:17192785 | path(EFO:"late-onset Alzheimers disease") equivalentTo path(EFO:"late-onset Alzheimers disease") |
| pubmed:17192785 | g(DBSNP:rs4420638) association path(EFO:"late-onset Alzheimers disease") |
| pubmed:18976728 | g(DBSNP:rs4420638) association path(MESH:"Alzheimer Disease") |
| pubmed:17474819 | g(DBSNP:rs4420638) association path(MESH:"Alzheimer Disease") |
| pubmed:17474819 | g(DBSNP:rs4420638) association g(HGNC:APOE) |
| pubmed:23175194 | a(NIFT:"Hippocampus volume") negativeCorrelation a(CONSO:"CDR - Sum of Boxes") |
| pubmed:25778476 | a(NIFT:"Hippocampus volume") association g(DBSNP:rs2732703) |
| pubmed:24524964 | a(NIFT:"Hippocampus volume") association a(CHEBI:homocysteine) |
| pubmed:25678559 | a(NIFT:"Hippocampus volume") negativeCorrelation p(HGNC:APP) |
| pubmed:19940480 | a(NIFT:"Hippocampus volume") negativeCorrelation p(HGNC:APOE, var("p.Cys130Arg")) |
| pubmed:22550605 | a(NIFT:"Hippocampus volume") association p(HGNC:TOMM40, var("?")) |
| pubmed:26043140 | a(EFO:"cognitive decline measurement") association a(CONSO:"CDR - Sum of Boxes") |
| pubmed:25542982 | a(NIFT:"3-HPMA/Cre ratio") negativeCorrelation a(CONSO:"CDR - Sum of Boxes") |
| pubmed:25542982 | a(NIFT:"3-HPMA/Cre ratio") negativeCorrelation a(NIFT:"Mini mental state exam") |
| pubmed:25542982 | a(NIFT:"3-HPMA/Cre ratio") negativeCorrelation a(NIFT:"Abeta_40_42_ratio") |
| pubmed:25542982 | a(NIFT:"3-HPMA/Cre ratio") positiveCorrelation a(InChI:"InChI=1S/C8H15NO4S/c1-6(11)9-7(8(12)13)5-14-4-2-3-10/h7,10H,2-5H2,1H3,(H,9,11)(H,12,13)/t7-/m0/s1") |
| pubmed:25542982 | a(NIFT:"3-HPMA/Cre ratio") negativeCorrelation a(CHEBI:creatinine) |
| pubmed:25542982 | a(NIFT:"Abeta_40_42_ratio") negativeCorrelation a(NIFT:"3-HPMA/Cre ratio") |
| pubmed:25542982 | a(InChI:"InChI=1S/C8H15NO4S/c1-6(11)9-7(8(12)13)5-14-4-2-3-10/h7,10H,2-5H2,1H3,(H,9,11)(H,12,13)/t7-/m0/s1") positiveCorrelation a(NIFT:"3-HPMA/Cre ratio") |
| pubmed:25542982 | a(CHEBI:creatinine) negativeCorrelation a(NIFT:"3-HPMA/Cre ratio") |
| pubmed:24242746 | p(HGNC:NEFL) positiveCorrelation a(CONSO:"CDR - Sum of Boxes") |
| pubmed:26836182 | p(HGNC:NEFL) positiveCorrelation p(HGNC:CHI3L1) |
| pubmed:25429309 | p(HGNC:SLC6A3) negativeCorrelation a(CONSO:"CDR - Sum of Boxes") |
| pubmed:30061532 | p(HGNC:SLC6A3) increases a(CHEBI:dopamine, loc(MESH:"Nerve Endings")) |
| pubmed:23775979 | complex(a(InChI:"InChI=1S/C22H21NO3/c1-17(24)23(16-18-10-6-8-14-21(18)25-2)20-13-7-9-15-22(20)26-19-11-4-3-5-12-19/h3-15H,16H2,1-2H3/i2-1"), p(HGNC:TSPO)) negativeCorrelation a(CONSO:"CDR - Sum of Boxes") |
| pubmed:23775979 | complex(a(InChI:"InChI=1S/C22H21NO3/c1-17(24)23(16-18-10-6-8-14-21(18)25-2)20-13-7-9-15-22(20)26-19-11-4-3-5-12-19/h3-15H,16H2,1-2H3/i2-1"), p(HGNC:TSPO)) negativeCorrelation a(NIFT:"Mini mental state exam") |
| pubmed:23775979 | complex(a(InChI:"InChI=1S/C22H21NO3/c1-17(24)23(16-18-10-6-8-14-21(18)25-2)20-13-7-9-15-22(20)26-19-11-4-3-5-12-19/h3-15H,16H2,1-2H3/i2-1"), p(HGNC:TSPO)) negativeCorrelation a(NIFT:"Logical Memory Immediate") |
| pubmed:23775979 | a(NIFT:"Logical Memory Immediate") negativeCorrelation complex(a(InChI:"InChI=1S/C22H21NO3/c1-17(24)23(16-18-10-6-8-14-21(18)25-2)20-13-7-9-15-22(20)26-19-11-4-3-5-12-19/h3-15H,16H2,1-2H3/i2-1"), p(HGNC:TSPO)) |
| pubmed:25566378 | path(GO:"short-term memory") positiveCorrelation a(NIFT:"Mini mental state exam") |
| pubmed:25566378 | path(GO:"short-term memory") negativeCorrelation a(CONSO:"CDR - Sum of Boxes") |
| pubmed:18346821 | a(MESH:"2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole") positiveCorrelation a(CONSO:"CDR - Sum of Boxes") |
| pubmed:27768893 | p(HGNC:KAT8) association bp(GO:"regulation of oxidative phosphorylation") |
| pubmed:27768893 | p(HGNC:KAT8) regulates complex(GO:"respiratory chain complex") |
| pubmed:21034527 | p(HGNC:KAT8) isA p(INTERPRO:"Histone acetyltransferase domain, MYST-type") |
| pubmed:22544363 | p(HGNC:KAT8) association p(HGNC:KANSL1) |
| pubmed:22544363 | p(HGNC:KAT8) association p(FPLX:"Histone_H4", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:27768893 | p(HGNC:KAT8) regulates bp(GO:"oxidative phosphorylation") |
| pubmed:27768893 | bp(GO:"regulation of oxidative phosphorylation") association p(HGNC:KAT8) |
| pubmed:24189435 | bp(GO:"regulation of oxidative phosphorylation") increases bp(GO:"mitochondrial electron transport, cytochrome c to oxygen") |
| pubmed:25778476 | p(HGNC:KANSL1) association g(DBSNP:rs113986870) |
| pubmed:22544363 | p(HGNC:KANSL1) association p(HGNC:KAT8) |
| pubmed:26293599 | p(HGNC:KANSL1) association p(HGNC:TP53, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:25778476 | g(DBSNP:rs113986870) association p(HGNC:KANSL1) |
| pubmed:25778476 | g(DBSNP:rs113986870) association g(DBSNP:rs2732703) |
| pubmed:25778476 | g(DBSNP:rs2732703) association g(DBSNP:rs113986870) |
| pubmed:25778476 | g(DBSNP:rs2732703) association a(NIFT:"Hippocampus volume") |
| pubmed:25478017 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) increases complex(a(CONSO:"Tau fibrils"), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212))) |
| pubmed:25478017 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) decreases a(CONSO:"Tau fibrils") |
| pubmed:17078951 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) negativeCorrelation p(FPLX:PKA) |
| pubmed:22072628 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) partOf p(CONSO:"proline-rich region 2", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21156028 | p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation", Thr, 688)) increases deg(p(HGNC:APP)) |
| pubmed:22110360 | act(p(FPLX:NFAT), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases bp(GO:"transcription, DNA-templated") |
| pubmed:22110360 | p(FPLX:CREB, pmod(go:0006468 ! "protein phosphorylation")) association bp(GO:"neuron differentiation") |
| pubmed:21677163 | p(FPLX:CREB) positiveCorrelation bp(GO:"long-term memory") |
| pubmed:21677163 | p(FPLX:CREB) positiveCorrelation p(HGNC:BDNF) |
| pubmed:20869593 | p(FPLX:CREB) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:19126755 | act(p(FPLX:CREB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates bp(GO:"gene expression") |
| pubmed:19126755 | act(p(FPLX:CREB)) association bp(MESH:"Neuronal Plasticity") |
| pubmed:19126755 | act(p(FPLX:CREB)) association path(MESH:"Tobacco Use Disorder") |
| pubmed:27550730 | act(p(FPLX:CREB)) negativeCorrelation act(p(HGNC:PDE5A)) |
| pubmed:27550730 | act(p(FPLX:CREB)) negativeCorrelation act(p(FPLX:HDAC)) |
| pubmed:27550730 | act(p(FPLX:CREB)) increases p(FPLX:Histone, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:21722302 | p(HGNC:SNCA, pmod(go:0006468 ! "protein phosphorylation")) increases p(HGNC:SNCA, pmod(CONSO:misfolded)) |
| pubmed:30985105 | p(HGNC:SNCA, pmod(go:0006468 ! "protein phosphorylation")) increases path(MESH:"Parkinson Disease") |
| pubmed:22110360 | complex(p(HGNC:DYRK1A), p(HGNC:JKAMP)) increases act(p(HGNC:MAP3K5)) |
| pubmed:22110360 | complex(p(HGNC:DYRK1A), p(HGNC:JKAMP)) increases bp(GO:"positive regulation of neuron apoptotic process") |
| pubmed:22110360 | act(p(HGNC:MAP3K5)) increases bp(GO:"positive regulation of neuron apoptotic process") |
| pubmed:22110360 | act(p(HGNC:MAP3K5)) increases bp(GO:"apoptotic process") |
| pubmed:22110360 | act(p(HGNC:MAP3K5)) increases p(FPLX:p38, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22110360 | act(p(HGNC:MAP3K5)) increases p(FPLX:JNK, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22530628 | p(HGNC:MAP3K5) increases bp(MESH:Apoptosis) |
| pubmed:21722302 | p(HGNC:MAP3K5) increases bp(MESH:Apoptosis) |
| pubmed:22530628 | act(p(HGNC:MAP3K5)) decreases bp(MESH:"Cell Survival") |
| pubmed:30697142 | p(HGNC:MAP3K5) decreases act(p(HGNC:MAPK8)) |
| pubmed:21722302 | p(HGNC:MAP3K5) increases bp(GO:"JNK cascade") |
| pubmed:27068745 | act(p(HGNC:MAP3K5)) positiveCorrelation act(p(HGNC:PRKD1)) |
| pubmed:27068745 | act(p(HGNC:MAP3K5)) increases act(p(FPLX:JNK)) |
| pubmed:27068745 | act(p(HGNC:MAP3K5)) association p(HGNC:CASP3) |
| pubmed:22110360 | act(p(FPLX:FOXO), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases bp(GO:"transcription, DNA-templated") |
| pubmed:" 26517285" | bp(GO:endocytosis) association g(HGNC:BIN1) |
| pubmed:" 26517285" | bp(GO:endocytosis) association g(HGNC:PICALM) |
| pubmed:" 26517285" | bp(GO:endocytosis) association g(HGNC:CD2AP) |
| pubmed:" 26517285" | bp(GO:endocytosis) association g(HGNC:EPHA1) |
| pubmed:" 26517285" | bp(GO:endocytosis) association g(HGNC:SORL1) |
| pubmed:30027901 | bp(GO:endocytosis) association act(p(HGNC:HTT)) |
| pubmed:29758300 | bp(GO:endocytosis) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | bp(GO:endocytosis) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | bp(GO:endocytosis) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | bp(GO:endocytosis) association p(HGNC:BECN1) |
| pubmed:22908190 | bp(GO:endocytosis) increases tloc(a(GO:"intrinsic component of plasma membrane"), fromLoc(GO:"plasma membrane"), toLoc(GO:lysosome)) |
| pubmed:22908190 | bp(GO:endocytosis) increases act(a(MESH:Neurons)) |
| pubmed:22908190 | bp(GO:endocytosis) association bp(GO:"regulation of synaptic plasticity") |
| pubmed:22908190 | bp(GO:endocytosis) increases bp(GO:memory) |
| pubmed:22908190 | bp(GO:endocytosis) increases bp(GO:learning) |
| pubmed:22908190 | bp(GO:endocytosis) increases bp(MESH:"Synaptic Transmission") |
| pubmed:22908190 | bp(GO:endocytosis) positiveCorrelation p(HGNC:APP) |
| pubmed:22908190 | bp(GO:endocytosis) positiveCorrelation g(CONSO:"APOE e4") |
| pubmed:22908190 | bp(GO:endocytosis) positiveCorrelation a(CHEBI:cholesterol) |
| pubmed:22908190 | bp(GO:endocytosis) positiveCorrelation a(MESH:Proteins) |
| pubmed:22908190 | bp(GO:endocytosis) positiveCorrelation a(CHEBI:lipid) |
| pubmed:22908190 | bp(GO:endocytosis) negativeCorrelation bp(GO:"lysosomal protein catabolic process") |
| pubmed:22908190 | bp(GO:endocytosis) positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:22908190 | bp(GO:endocytosis) positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:22908190 | bp(GO:endocytosis) positiveCorrelation act(a(GO:synapse)) |
| pubmed:22908190 | bp(GO:endocytosis) positiveCorrelation p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") |
| pubmed:22908190 | bp(GO:endocytosis) positiveCorrelation tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) |
| pubmed:18930136 | bp(GO:endocytosis) increases a(GO:lysosome) |
| pubmed:29590627 | bp(GO:endocytosis) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:29590627 | bp(GO:endocytosis) increases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:29590627 | bp(GO:endocytosis) increases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:28420982 | bp(GO:endocytosis) increases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:endosome), toLoc(GO:lysosome)) |
| pubmed:29686391 | bp(GO:endocytosis) positiveCorrelation bp(GO:"mitotic G1 phase") |
| pubmed:22110360 | act(p(HGNC:AMPH)) increases bp(GO:endocytosis) |
| pubmed:22110360 | act(p(HGNC:AMPH)) increases bp(GO:"synaptic vesicle budding from endosome") |
| pubmed:22110360 | bp(GO:"response to endoplasmic reticulum stress") increases act(p(HGNC:MAP3K5)) |
| pubmed:27299292 | bp(GO:"response to endoplasmic reticulum stress") increases tloc(p(HGNC:TFE3), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:27299292 | bp(GO:"response to endoplasmic reticulum stress") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:27299292 | bp(GO:"response to endoplasmic reticulum stress") increases act(p(HGNC:TFEB)) |
| pubmed:27299292 | bp(GO:"response to endoplasmic reticulum stress") association p(HGNC:EIF2AK3) |
| pubmed:27299292 | bp(GO:"response to endoplasmic reticulum stress") association act(p(HGNC:PPP3CA), ma(go:0016791 ! "phosphatase activity")) |
| pubmed:24563850 | bp(GO:"response to endoplasmic reticulum stress") increases act(p(HGNC:HSPA5)) |
| pubmed:24563850 | bp(GO:"response to endoplasmic reticulum stress") decreases bp(CONSO:misfolding) |
| pubmed:24563850 | bp(GO:"response to endoplasmic reticulum stress") decreases bp(GO:"cell death") |
| pubmed:24563850 | bp(GO:"response to endoplasmic reticulum stress") increases bp(GO:"cell death") |
| pubmed:24563850 | bp(GO:"response to endoplasmic reticulum stress") increases bp(GO:"apoptotic process") |
| pubmed:26142647 | bp(GO:"response to endoplasmic reticulum stress") increases p(HGNC:PPP1R15A) |
| pubmed:23702978 | bp(GO:"response to endoplasmic reticulum stress") increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:22110360 | p(FPLX:p38, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(FPLX:p38)) |
| pubmed:29121589 | p(FPLX:p38, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(FPLX:p38)) |
| pubmed:11880483 | p(FPLX:p38, pmod(go:0006468 ! "protein phosphorylation")) association p(HGNC:BDNF) |
| pubmed:11880483 | p(FPLX:p38, pmod(go:0006468 ! "protein phosphorylation")) association bp(GO:"regulation of synaptic plasticity") |
| pubmed:22110360 | p(HGNC:DAXX) increases act(p(HGNC:MAP3K5)) |
| pubmed:22110360 | p(FPLX:TXN) directlyDecreases act(p(HGNC:MAP3K5)) |
| pubmed:22110360 | p(FPLX:"p14_3_3") directlyDecreases act(p(HGNC:MAP3K5)) |
| pubmed:22040696 | p(FPLX:"p14_3_3") increases p(FPLX:CHRN) |
| pubmed:31248781 | bp(GO:"stress-activated protein kinase signaling cascade") negativeCorrelation bp(MESH:Neuroprotection) |
| pubmed:22110360 | complex(p(FPLX:MEK), p(FPLX:RAF), p(FPLX:RAS)) increases act(p(FPLX:ERK)) |
| pubmed:19293145 | act(p(FPLX:RAS)) increases p(HGNC:STAT3) |
| pubmed:18986241 | p(FPLX:RAS) association bp(GO:"phosphatidylinositol 3-kinase signaling") |
| pubmed:18986241 | p(FPLX:RAS) association bp(GO:"protein kinase B signaling") |
| pubmed:21034527 | p(INTERPRO:"Amyloidogenic glycoprotein, intracellular domain, conserved site") association act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:21034527 | complex(p(HGNC:APBB1), p(HGNC:KAT8), p(INTERPRO:"Amyloidogenic glycoprotein, intracellular domain, conserved site")) increases act(p(HGNC:LGALS4)) |
| pubmed:21034527 | complex(p(HGNC:APBB1), p(HGNC:TFCP2), p(INTERPRO:"Amyloidogenic glycoprotein, intracellular domain, conserved site")) increases act(p(HGNC:GSK3B)) |
| pubmed:21034527 | act(p(HGNC:SP1), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) association p(HGNC:APBB1) |
| pubmed:23092889 | p(HGNC:EIF2AK2) increases bp(GO:"inflammatory response") |
| pubmed:23092889 | p(HGNC:EIF2AK2) association p(HGNC:MAPK1) |
| pubmed:23092889 | p(HGNC:EIF2AK2) increases p(HGNC:IRF3) |
| pubmed:23092889 | p(HGNC:EIF2AK2) increases p(HGNC:NFKB1) |
| pubmed:23092889 | p(HGNC:EIF2AK2) regulates bp(GO:"neuron apoptotic process") |
| pubmed:23092889 | p(HGNC:EIF2AK2) increases bp(GO:autophagy) |
| pubmed:23092889 | p(HGNC:EIF2AK2) increases act(complex(GO:"inflammasome complex")) |
| pubmed:23092889 | p(HGNC:EIF2AK2) increases act(complex(GO:"inflammasome complex")) |
| pubmed:23092889 | act(p(HGNC:EIF2AK2)) increases complex(p(HGNC:EIF2AK2), p(HGNC:NLRP1)) |
| pubmed:23092889 | act(p(HGNC:EIF2AK2)) increases complex(p(HGNC:EIF2AK2), p(HGNC:NLRP3)) |
| pubmed:23092889 | act(p(HGNC:EIF2AK2)) increases complex(p(HGNC:EIF2AK2), p(HGNC:NLRC4)) |
| pubmed:23092889 | act(p(HGNC:EIF2AK2)) increases complex(p(HGNC:AIM2), p(HGNC:EIF2AK2)) |
| pubmed:24173717 | bp(GO:pyroptosis) negativeCorrelation p(HGNC:TUBB6) |
| pubmed:23092889 | p(HGNC:YME1L1) increases p(HGNC:EIF2AK2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23092889 | p(HGNC:EIF2AK2, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(HGNC:EIF2AK2)) |
| pubmed:23092889 | complex(p(HGNC:EIF2AK2), p(HGNC:NLRP1)) increases act(complex(GO:"inflammasome complex")) |
| pubmed:23092889 | complex(p(HGNC:EIF2AK2), p(HGNC:NLRP3)) increases act(complex(GO:"inflammasome complex")) |
| pubmed:23092889 | complex(p(HGNC:EIF2AK2), p(HGNC:NLRC4)) increases act(complex(GO:"inflammasome complex")) |
| pubmed:23092889 | complex(p(HGNC:AIM2), p(HGNC:EIF2AK2)) increases act(complex(GO:"inflammasome complex")) |
| pubmed:22544363 | p(FPLX:"Histone_H4", pmod(go:0006473 ! "protein acetylation")) association p(HGNC:KAT8) |
| pubmed:22544363 | p(FPLX:"Histone_H4", pmod(go:0006473 ! "protein acetylation")) association bp(GO:"regulation of gene expression, epigenetic") |
| pubmed:22544363 | bp(GO:"regulation of gene expression, epigenetic") association p(FPLX:"Histone_H4", pmod(go:0006473 ! "protein acetylation")) |
| pubmed:30988501 | bp(GO:"regulation of gene expression, epigenetic") regulates bp(MESH:"Immunity, Innate") |
| pubmed:11880483 | p(HGNCGENEFAMILY:"Mitogen-activated protein kinases", pmod(go:0006468 ! "protein phosphorylation")) association p(HGNC:BDNF) |
| pubmed:11880483 | p(HGNCGENEFAMILY:"Mitogen-activated protein kinases", pmod(go:0006468 ! "protein phosphorylation")) association bp(GO:"regulation of synaptic plasticity") |
| pubmed:18986241 | p(HGNCGENEFAMILY:"Mitogen-activated protein kinases", pmod(go:0006468 ! "protein phosphorylation")) increases act(p(HGNCGENEFAMILY:"Mitogen-activated protein kinases")) |
| pubmed:18986241 | act(p(HGNCGENEFAMILY:"Mitogen-activated protein kinases")) association bp(GO:"neuron projection development") |
| pubmed:21861815 | p(HGNCGENEFAMILY:"Mitogen-activated protein kinases") increases p(HGNC:HIF1A, pmod(go:0006468 ! "protein phosphorylation", Thr, 796)) |
| pubmed:21861815 | p(HGNCGENEFAMILY:"Mitogen-activated protein kinases") increases act(p(MESH:"Hypoxia-Inducible Factor 1")) |
| pubmed:26136662 | p(FPLX:Histone, pmod(go:0006473 ! "protein acetylation", Lys, 280)) association path(MESH:"Alzheimer Disease") |
| pubmed:27041503 | p(HGNC:WWC1) decreases p(HGNC:GRIA1) |
| pubmed:27041503 | p(HGNC:WWC1) decreases bp(GO:"actin polymerization or depolymerization") |
| pubmed:25800888 | p(HGNC:WWC1) association bp(GO:"regulation of synaptic plasticity") |
| pubmed:25800888 | p(HGNC:WWC1) association g(DBSNP:rs17070145) |
| pubmed:27041503 | p(HGNC:WWC1) association bp(GO:memory) |
| pubmed:27041503 | p(HGNC:WWC1) negativeCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:27041503 | bp(GO:"actin polymerization or depolymerization") increases bp(GO:"long-term synaptic depression") |
| pubmed:25570489 | a(NIFT:"Hippocampal atrophy") association p(HGNC:ESR1) |
| pubmed:20100581 | a(NIFT:"Hippocampal atrophy") association bp(GO:"apoptotic process") |
| pubmed:20065247 | a(NIFT:"Hippocampal atrophy") positiveCorrelation p(HGNC:APP) |
| pubmed:24028866 | a(NIFT:"Hippocampal atrophy") positiveCorrelation a(CHEBI:homocysteine) |
| pubmed:21871088 | a(NIFT:"Hippocampal atrophy") association bp(GO:"microglial cell activation") |
| pubmed:20869593 | path(MESH:"Frontotemporal Dementia") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30061532 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:12428809 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(CONSO:"4R tau") |
| pubmed:26751493 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(CONSO:"4R tau") |
| pubmed:22299660 | path(MESH:"Frontotemporal Dementia") association p(FPLX:PPP2) |
| pubmed:22299660 | path(MESH:"Frontotemporal Dementia") association p(HGNC:MAPT, var("?")) |
| pubmed:29758300 | path(MESH:"Frontotemporal Dementia") association p(HGNC:MAPT) |
| pubmed:28420982 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT) |
| pubmed:29758300 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:TARDBP, pmod(CONSO:misfolding)) |
| pubmed:30116051 | path(MESH:"Frontotemporal Dementia") association p(HGNC:SQSTM1) |
| pubmed:30116051 | path(MESH:"Frontotemporal Dementia") association p(HGNC:C9orf72) |
| pubmed:30116051 | path(MESH:"Frontotemporal Dementia") association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30116051 | path(MESH:"Frontotemporal Dementia") increases act(p(HGNC:ABL1)) |
| pubmed:29024336 | path(MESH:"Frontotemporal Dementia") increases path(MESH:"Proteostasis Deficiencies") |
| pubmed:24027553 | path(MESH:"Frontotemporal Dementia") association p(HGNC:MAPT, var("p.Pro301Leu")) |
| pubmed:26751493 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pubmed:23294633 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pubmed:24027553 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:NPEPPS) |
| pubmed:30108137 | path(MESH:"Frontotemporal Dementia") increases r(HGNC:TFEB) |
| pubmed:30108137 | path(MESH:"Frontotemporal Dementia") increases r(HGNC:LAMP1) |
| pubmed:30108137 | path(MESH:"Frontotemporal Dementia") increases p(HGNC:TFEB) |
| pubmed:30108137 | path(MESH:"Frontotemporal Dementia") increases p(HGNC:LAMP1) |
| pubmed:30108137 | path(MESH:"Frontotemporal Dementia") increases p(HGNC:CTSD) |
| pubmed:28420982 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:28420982 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) |
| pubmed:26751493 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Val337Met")) |
| pubmed:26751493 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Gly272Val")) |
| pubmed:26751493 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Arg406Trp")) |
| pubmed:26751493 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:PSEN1, var("p.Gly183Val")) |
| pubmed:26631930 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:29980653 | path(MESH:"Frontotemporal Dementia") isA path(MESH:"Neurodegenerative Diseases") |
| pubmed:29980653 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:TARDBP, var("?")) |
| pubmed:8391280 | path(MESH:"Frontotemporal Dementia") positiveCorrelation g(DBSNP:rs63750424) |
| pubmed:26293599 | p(HGNC:TP53, pmod(go:0006473 ! "protein acetylation")) association p(HGNC:KANSL1) |
| pubmed:26293599 | p(HGNC:BTG2) association p(HGNC:TP53) |
| pubmed:26293599 | p(HGNC:BTG2) increases bp(GO:"activation of MAPKK activity") |
| pubmed:15601849 | bp(GO:"activation of MAPKK activity") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30515821 | bp(GO:"oxidative phosphorylation") increases a(CHEBI:ATP) |
| pubmed:30515821 | bp(GO:"oxidative phosphorylation") positiveCorrelation p(HGNC:DNM1) |
| pubmed:30027901 | bp(GO:"oxidative phosphorylation") association path(MESH:"Huntington Disease") |
| pubmed:30126037 | bp(GO:"oxidative phosphorylation") decreases bp(GO:"oxygen transport") |
| pubmed:24189435 | bp(GO:"mitochondrial electron transport, cytochrome c to oxygen") association bp(GO:"response to oxidative stress") |
| pubmed:22710270 | p(HGNC:PSEN1, var("p.Glu280Ala")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22710270 | g(HGNC:CD44) association path(MESH:"Alzheimer Disease") |
| pubmed:22710270 | g(HGNC:CD44) association g(DBSNP:rs187116) |
| pubmed:22710270 | g(DBSNP:rs187116) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22710270 | g(DBSNP:rs187116) association g(HGNC:CD44) |
| pubmed:22710270 | g(HGNC:NPHP1) association path(MESH:"Alzheimer Disease") |
| pubmed:22710270 | g(HGNC:NPHP1) association g(DBSNP:rs10173717) |
| pubmed:22710270 | g(DBSNP:rs10173717) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22710270 | g(DBSNP:rs10173717) association g(HGNC:NPHP1) |
| pubmed:22710270 | g(HGNC:CADPS2) association path(MESH:"Alzheimer Disease") |
| pubmed:22710270 | g(HGNC:CADPS2) association g(DBSNP:rs3757536) |
| pubmed:22710270 | g(DBSNP:rs3757536) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22710270 | g(DBSNP:rs3757536) association g(HGNC:CADPS2) |
| pubmed:22710270 | g(HGNC:GREM2) association path(MESH:"Alzheimer Disease") |
| pubmed:22710270 | g(HGNC:GREM2) association g(DBSNP:rs12129547) |
| pubmed:22710270 | g(DBSNP:rs12129547) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22710270 | g(DBSNP:rs12129547) association g(HGNC:GREM2) |
| pubmed:21769591 | g(DBSNP:rs11542041) transcribedTo r(DBSNP:rs11542041) |
| pubmed:21769591 | r(DBSNP:rs11542041) translatedTo p(HGNC:APOE, var("p.Arg132Ser")) |
| pubmed:21769591 | p(HGNC:APOE, var("p.Arg132Ser")) directlyDecreases act(p(HGNC:APOE)) |
| pubmed:18191876 | p(HGNC:A2M, var("p.Val1000Ile")) association path(MESH:"Alzheimer Disease") |
| pubmed:26195256 | p(HGNC:A2M) decreases a(CHEBI:amyloid-beta) |
| pubmed:18191876 | g(DBSNP:rs669) association path(MESH:"Alzheimer Disease") |
| pubmed:18191876 | g(DBSNP:rs669) association path(MESH:"Alzheimer Disease") |
| pubmed:18191876 | p(HGNC:OLR1) association path(MESH:"Alzheimer Disease") |
| pubmed:18191876 | p(HGNC:OLR1) association path(MESH:"Alzheimer Disease") |
| pubmed:20693622 | p(HGNC:CYP46A1) increases a(CHEBI:24-hydroxycholesterol) |
| pubmed:20693622 | p(HGNC:CYP46A1) association path(MESH:"Alzheimer Disease") |
| pubmed:20693622 | p(HGNC:CYP46A1) association g(DBSNP:rs3783320) |
| pubmed:20693622 | g(DBSNP:rs8003602) association g(HGNC:CYP46A1) |
| pubmed:20693622 | g(DBSNP:rs8003602) association path(MESH:"Alzheimer Disease") |
| pubmed:20693622 | g(HGNC:CYP46A1) association g(DBSNP:rs8003602) |
| pubmed:20693622 | g(DBSNP:rs3783320) association p(HGNC:CYP46A1) |
| pubmed:20693622 | g(DBSNP:rs3783320) association path(MESH:"Alzheimer Disease") |
| pubmed:20693622 | act(p(HGNC:MYT1), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases g(HGNC:CYP46A1) |
| pubmed:19926167 | g(DBSNP:rs17571) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21892414 | p(HGNC:CLU) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22159054 | p(HGNC:CLU) association path(MESH:"Alzheimer Disease") |
| pubmed:21543606 | p(HGNC:CLU) association g(DBSNP:rs11136000) |
| pubmed:21543606 | p(HGNC:CLU) decreases a(NIFT:"Fractional anisotropy") |
| pubmed:21543606 | p(HGNC:CLU) association p(HGNC:APP, frag("672_713")) |
| pubmed:21892414 | g(DBSNP:rs9331888) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19734903 | g(DBSNP:rs9331888) association g(HGNC:CLU) |
| pubmed:22244847 | p(HGNC:CR1) increases bp(GO:"long-term synaptic depression") |
| pubmed:22244847 | g(DBSNP:rs6656401) increases bp(GO:"long-term synaptic depression") |
| pubmed:22262751 | g(DBSNP:rs6656401) association a(CHEBI:amyloid-beta) |
| pubmed:19734903 | g(DBSNP:rs6656401) association path(MESH:"Alzheimer Disease") |
| pubmed:19734903 | g(DBSNP:rs6656401) association g(HGNC:CLU) |
| pubmed:24162737 | g(DBSNP:rs6656401) association g(HGNC:CR1) |
| pubmed:19734903 | g(DBSNP:rs6656401) association g(HGNC:CR1) |
| pubmed:22410445 | g(HGNC:SORL1) association bp(GO:"pre-B cell receptor expression") |
| pubmed:17975299 | g(HGNC:SORL1) association path(MESH:"Alzheimer Disease") |
| pubmed:24162737 | g(HGNC:SORL1) association g(DBSNP:rs11218343) |
| pubmed:23565137 | g(HGNC:SORL1) association g(DBSNP:rs11218343) |
| pubmed:" 26517285" | g(HGNC:SORL1) association bp(GO:endocytosis) |
| pubmed:" 26517285" | g(HGNC:SORL1) association bp(GO:"lipid metabolic process") |
| pubmed:26996954 | g(HGNC:SORL1) association g(DBSNP:rs3824968) |
| pubmed:26996954 | g(HGNC:SORL1) association g(DBSNP:rs3824968) |
| pubmed:26996954 | g(HGNC:SORL1) association path(MESH:"Cerebrovascular Disorders") |
| pubmed:22410445 | bp(GO:"pre-B cell receptor expression") association g(HGNC:SORL1) |
| pubmed:22410445 | g(DBSNP:rs1699102) decreases bp(GO:"pre-B cell receptor expression") |
| pubmed:22410445 | g(DBSNP:rs2070045) decreases bp(GO:"pre-B cell receptor expression") |
| pubmed:22382309 | g(HGNC:CD33) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22167654 | g(HGNC:CD33) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21460841 | g(HGNC:CD33) association path(MESH:"Alzheimer Disease") |
| pubmed:22382309 | g(HGNC:CD33) association g(DBSNP:rs3865444) |
| pubmed:21460841 | g(HGNC:CD33) association g(DBSNP:rs3865444) |
| pubmed:24162737 | g(HGNC:CD33) association g(DBSNP:rs3865444) |
| pubmed:21460841 | g(HGNC:CD33) association g(DBSNP:rs3865444) |
| pubmed:22167654 | g(HGNC:CD33) association g(DBSNP:rs3826656) |
| pubmed:18976728 | g(HGNC:CD33) association g(DBSNP:rs3826656) |
| pubmed:" 26517285" | g(HGNC:CD33) association bp(GO:"immune response") |
| pubmed:22382309 | g(DBSNP:rs3865444) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21460841 | g(DBSNP:rs3865444) association path(MESH:"Alzheimer Disease") |
| pubmed:22382309 | g(DBSNP:rs3865444) association g(HGNC:CD33) |
| pubmed:21460841 | g(DBSNP:rs3865444) association g(HGNC:CD33) |
| pubmed:24162737 | g(DBSNP:rs3865444) association g(HGNC:CD33) |
| pubmed:21460841 | g(DBSNP:rs3865444) association g(HGNC:CD33) |
| pubmed:22382309 | g(HGNC:MS4A6A) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22382309 | g(HGNC:MS4A6A) association g(DBSNP:rs610932) |
| pubmed:21460840 | g(HGNC:MS4A6A) association g(DBSNP:rs610932) |
| pubmed:21627779 | g(HGNC:MS4A6A) association g(DBSNP:rs1562990) |
| pubmed:21460841 | g(HGNC:MS4A6A) association g(DBSNP:rs4938933) |
| pubmed:22382309 | g(DBSNP:rs610932) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21460840 | g(DBSNP:rs610932) association path(MESH:"Alzheimer Disease") |
| pubmed:22382309 | g(DBSNP:rs610932) association g(HGNC:MS4A6A) |
| pubmed:21460840 | g(DBSNP:rs610932) association g(HGNC:MS4A6A) |
| pubmed:21460840 | g(DBSNP:rs610932) association g(HGNC:MS4A1) |
| pubmed:22167654 | g(DBSNP:rs3826656) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22167654 | g(DBSNP:rs3826656) association g(HGNC:CD33) |
| pubmed:18976728 | g(DBSNP:rs3826656) association g(HGNC:CD33) |
| pubmed:22167654 | g(HGNC:GOLM1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22167654 | g(HGNC:GOLM1) association g(DBSNP:rs10868366) |
| pubmed:22167654 | g(HGNC:GOLM1) association g(DBSNP:rs7019241) |
| pubmed:22167654 | g(DBSNP:rs10868366) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22167654 | g(DBSNP:rs10868366) association g(HGNC:GOLM1) |
| pubmed:22167654 | g(DBSNP:rs7019241) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22167654 | g(DBSNP:rs7019241) association g(HGNC:GOLM1) |
| pubmed:21285854 | g(HGNC:GAB2) association path(MESH:"Alzheimer Disease") |
| pubmed:17553421 | g(HGNC:GAB2) association path(MESH:"Alzheimer Disease") |
| pubmed:21285854 | g(HGNC:GAB2) association g(DBSNP:rs4945261) |
| pubmed:21285854 | g(HGNC:GAB2) association g(DBSNP:rs7101429) |
| pubmed:21285854 | g(HGNC:GAB2) association g(DBSNP:rs7115850) |
| pubmed:17553421 | g(HGNC:GAB2) association g(DBSNP:rs2373115) |
| pubmed:17553421 | g(HGNC:GAB2) association g(DBSNP:rs2373115) |
| pubmed:21285854 | g(DBSNP:rs4945261) association g(HGNC:GAB2) |
| pubmed:21285854 | g(DBSNP:rs4945261) association path(MESH:"Alzheimer Disease") |
| pubmed:21285854 | g(DBSNP:rs7101429) association g(HGNC:GAB2) |
| pubmed:21285854 | g(DBSNP:rs7101429) association path(MESH:"Alzheimer Disease") |
| pubmed:21285854 | g(DBSNP:rs7115850) association g(HGNC:GAB2) |
| pubmed:21285854 | g(DBSNP:rs7115850) association path(MESH:"Alzheimer Disease") |
| pubmed:22159054 | p(HGNC:NECTIN2) association path(MESH:"Alzheimer Disease") |
| pubmed:22159054 | g(DBSNP:rs6859) association path(MESH:"Alzheimer Disease") |
| pubmed:22159054 | g(DBSNP:rs6859) association g(HGNC:NECTIN2) |
| pubmed:18823527 | g(DBSNP:rs6859) association g(HGNC:NECTIN2) |
| pubmed:20885792 | g(DBSNP:rs6859) association g(HGNC:NECTIN2) |
| pubmed:22159054 | p(HGNC:PICALM) association path(MESH:"Alzheimer Disease") |
| pubmed:29626319 | p(HGNC:PICALM) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27260836 | p(HGNC:PICALM) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | p(HGNC:PICALM) positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:29758300 | p(HGNC:PICALM) increases a(CHEBI:amyloid-beta) |
| pubmed:29758300 | p(HGNC:PICALM) increases tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:"Endothelial Cells"), toLoc(MESH:Blood)) |
| pubmed:29626319 | p(HGNC:PICALM) increases tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:"Blood-Brain Barrier"), toLoc(MESH:Blood)) |
| pubmed:29626319 | p(HGNC:PICALM) decreases a(CHEBI:amyloid-beta) |
| pubmed:29758300 | p(HGNC:PICALM) increases path(MESH:"Plaque, Amyloid") |
| pubmed:29758300 | p(HGNC:PICALM) increases bp(GO:"clathrin-dependent endocytosis") |
| pubmed:29758300 | p(HGNC:PICALM) increases tloc(complex(GO:"gamma-secretase complex"), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) |
| pubmed:29758300 | p(HGNC:PICALM) regulates bp(GO:macroautophagy) |
| pubmed:29758300 | p(HGNC:PICALM) increases tloc(complex(GO:"SNARE complex"), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) |
| pubmed:27260836 | p(HGNC:PICALM) increases complex(p(CONSO:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) |
| pubmed:27260836 | p(HGNC:PICALM) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27260836 | p(HGNC:PICALM) partOf path(CONSO:"granulovacuolar degeneration") |
| pubmed:27260836 | p(HGNC:PICALM) negativeCorrelation p(HGNC:MAP1LC3B) |
| pubmed:27260836 | p(HGNC:PICALM) positiveCorrelation p(HGNC:BECN1) |
| pubmed:22159054 | p(HGNC:BIN1) association path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | p(HGNC:BIN1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | p(HGNC:BIN1) increases bp(GO:endocytosis) |
| pubmed:29758300 | p(HGNC:BIN1) increases bp(GO:"amyloid precursor protein metabolic process") |
| pubmed:29758300 | p(HGNC:BIN1) increases bp(GO:autophagy) |
| pubmed:29758300 | p(HGNC:BIN1) decreases a(CHEBI:amyloid-beta) |
| pubmed:29758300 | p(HGNC:BIN1) positiveCorrelation path(MESH:Tauopathies) |
| pubmed:22159054 | p(HGNC:EPHA1) association path(MESH:"Alzheimer Disease") |
| pubmed:22159054 | p(HGNC:MS4A7) association path(MESH:"Alzheimer Disease") |
| pubmed:22159054 | p(HGNC:ABCA7) association path(MESH:"Alzheimer Disease") |
| pubmed:23556446 | p(HGNC:ABCA7) association path(MESH:"Alzheimer Disease") |
| pubmed:29626319 | p(HGNC:ABCA7) association bp(GO:phagocytosis) |
| pubmed:29626319 | p(HGNC:ABCA7) regulates bp(GO:phagocytosis) |
| pubmed:29626319 | p(HGNC:ABCA7) decreases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | p(HGNC:ABCA7) decreases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | p(HGNC:ABCA7) decreases p(HGNC:BACE1) |
| pubmed:22159054 | p(HGNC:CD33) association path(MESH:"Alzheimer Disease") |
| pubmed:29626319 | p(HGNC:CD33) association bp(GO:phagocytosis) |
| pubmed:29626319 | p(HGNC:CD33) decreases deg(a(CHEBI:amyloid-beta)) |
| pubmed:10887109 | p(HGNC:CD33) regulates path(MESH:Myelopoiesis) |
| pubmed:10887109 | p(HGNC:CD33) causesNoChange a(CHEBI:"calcium(2+)") |
| pubmed:10887109 | p(HGNC:CD33) association act(p(HGNC:FCGR1A)) |
| pubmed:22005930 | g(HGNC:SLC29A2) association path(MESH:"Alzheimer Disease") |
| pubmed:22005930 | g(HGNC:SLC29A2) association g(DBSNP:rs6834555) |
| pubmed:22005930 | g(DBSNP:rs6834555) association path(MESH:"Alzheimer Disease") |
| pubmed:22005930 | g(DBSNP:rs6834555) association g(HGNC:SLC29A2) |
| pubmed:22005930 | g(HGNC:VSNL1) association path(MESH:"Alzheimer Disease") |
| pubmed:22005930 | g(HGNC:VSNL1) association g(DBSNP:rs4038131) |
| pubmed:22005930 | g(HGNC:VSNL1) association g(DBSNP:rs4038131) |
| pubmed:22005930 | g(DBSNP:rs4038131) association path(MESH:"Alzheimer Disease") |
| pubmed:22005930 | g(DBSNP:rs4038131) association g(HGNC:VSNL1) |
| pubmed:22005930 | g(DBSNP:rs4038131) association g(HGNC:VSNL1) |
| pubmed:21460840 | g(HGNC:ABCA7) association path(MESH:"Alzheimer Disease") |
| pubmed:21460840 | g(HGNC:ABCA7) association g(DBSNP:rs3764650) |
| pubmed:21460840 | g(HGNC:ABCA7) association g(DBSNP:rs3764650) |
| pubmed:24162737 | g(HGNC:ABCA7) association g(DBSNP:rs4147929) |
| pubmed:21460841 | g(HGNC:ABCA7) association g(DBSNP:rs3752246) |
| pubmed:23571587 | g(HGNC:ABCA7) association g(DBSNP:rs115550680) |
| pubmed:" 26517285" | g(HGNC:ABCA7) association bp(GO:"immune response") |
| pubmed:" 26517285" | g(HGNC:ABCA7) association bp(GO:"lipid transport") |
| pubmed:21460840 | g(DBSNP:rs3764650) association path(MESH:"Alzheimer Disease") |
| pubmed:21460840 | g(DBSNP:rs3764650) association g(HGNC:ABCA7) |
| pubmed:21460840 | g(DBSNP:rs3764650) association g(HGNC:ABCA7) |
| pubmed:21460840 | g(HGNC:MS4A1) association path(MESH:"Alzheimer Disease") |
| pubmed:21460840 | g(HGNC:MS4A1) association g(DBSNP:rs610932) |
| pubmed:" 26517285" | g(HGNC:MS4A1) association bp(GO:"immune response") |
| pubmed:18823527 | g(HGNC:LRAT) association path(MESH:"Alzheimer Disease") |
| pubmed:18823527 | g(HGNC:LRAT) association g(DBSNP:rs201825) |
| pubmed:18823527 | g(DBSNP:rs201825) association path(MESH:"Alzheimer Disease") |
| pubmed:18823527 | g(DBSNP:rs201825) association g(HGNC:LRAT) |
| pubmed:18823527 | g(DBSNP:rs727153) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(DBSNP:rs2075650) association path(MESH:"Alzheimer Disease") |
| pubmed:20460622 | g(DBSNP:rs2075650) association path(MESH:"Alzheimer Disease") |
| pubmed:20061627 | g(DBSNP:rs2075650) association path(MESH:"Alzheimer Disease") |
| pubmed:20885792 | g(DBSNP:rs2075650) association path(MESH:"Alzheimer Disease") |
| pubmed:21123754 | g(DBSNP:rs2075650) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(DBSNP:rs2075650) association g(HGNC:APOE) |
| pubmed:20460622 | g(DBSNP:rs2075650) association g(HGNC:APOE) |
| pubmed:20885792 | g(DBSNP:rs2075650) association g(HGNC:APOE) |
| pubmed:20061627 | g(DBSNP:rs2075650) association g(HGNC:TOMM40) |
| pubmed:21123754 | g(DBSNP:rs2075650) association g(HGNC:TOMM40) |
| pubmed:21123754 | g(DBSNP:rs2075650) association g(HGNC:TOMM40) |
| pubmed:19734902 | g(DBSNP:rs2075650) association g(HGNC:TOMM40) |
| pubmed:19734903 | g(DBSNP:rs2075650) association g(HGNC:TOMM40) |
| pubmed:20061627 | g(DBSNP:rs2075650) association g(HGNC:TOMM40) |
| pubmed:20885792 | g(DBSNP:rs2075650) association g(HGNC:TOMM40) |
| pubmed:20460622 | g(DBSNP:rs2075650) association g(HGNC:TOMM40) |
| pubmed:27004735 | g(DBSNP:rs2075650) association p(HGNC:TOMM40) |
| pubmed:19734902 | g(HGNC:CLU) association path(MESH:"Alzheimer Disease") |
| pubmed:19734903 | g(HGNC:CLU) association path(MESH:"Alzheimer Disease") |
| pubmed:21627779 | g(HGNC:CLU) association path(MESH:"Alzheimer Disease") |
| pubmed:21460841 | g(HGNC:CLU) association path(MESH:"Alzheimer Disease") |
| pubmed:21379329 | g(HGNC:CLU) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(HGNC:CLU) association g(DBSNP:rs11136000) |
| pubmed:21379329 | g(HGNC:CLU) association g(DBSNP:rs11136000) |
| pubmed:19734902 | g(HGNC:CLU) association g(DBSNP:rs11136000) |
| pubmed:19734903 | g(HGNC:CLU) association g(DBSNP:rs11136000) |
| pubmed:19734903 | g(HGNC:CLU) association g(DBSNP:rs6656401) |
| pubmed:21627779 | g(HGNC:CLU) association g(DBSNP:rs569214) |
| pubmed:21627779 | g(HGNC:CLU) association g(DBSNP:rs569214) |
| pubmed:21460841 | g(HGNC:CLU) association g(DBSNP:rs1532278) |
| pubmed:21460841 | g(HGNC:CLU) association g(DBSNP:rs1532278) |
| pubmed:24162737 | g(HGNC:CLU) association g(DBSNP:rs9331896) |
| pubmed:19734903 | g(HGNC:CLU) association g(DBSNP:rs2279590) |
| pubmed:19734903 | g(HGNC:CLU) association g(DBSNP:rs9331888) |
| pubmed:" 26517285" | g(HGNC:CLU) association bp(GO:"immune response") |
| pubmed:" 26517285" | g(HGNC:CLU) association bp(GO:"lipid transport") |
| pubmed:" 26517285" | g(HGNC:CLU) association g(DBSNP:rs3824968) |
| pubmed:19734902 | g(DBSNP:rs11136000) association path(MESH:"Alzheimer Disease") |
| pubmed:19734903 | g(DBSNP:rs11136000) association path(MESH:"Alzheimer Disease") |
| pubmed:21379329 | g(DBSNP:rs11136000) association path(MESH:"Alzheimer Disease") |
| pubmed:21543606 | g(DBSNP:rs11136000) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(DBSNP:rs11136000) association g(HGNC:CLU) |
| pubmed:21379329 | g(DBSNP:rs11136000) association g(HGNC:CLU) |
| pubmed:19734902 | g(DBSNP:rs11136000) association g(HGNC:CLU) |
| pubmed:19734903 | g(DBSNP:rs11136000) association g(HGNC:CLU) |
| pubmed:19734903 | g(DBSNP:rs11136000) association g(HGNC:APOE) |
| pubmed:21543606 | g(DBSNP:rs11136000) association p(HGNC:CLU) |
| pubmed:19136949 | g(HGNC:PCDH11X) association path(MESH:"Alzheimer Disease") |
| pubmed:19136949 | g(HGNC:PCDH11X) association g(DBSNP:rs5984894) |
| pubmed:19136949 | g(HGNC:PCDH11X) association g(DBSNP:rs2573905) |
| pubmed:19136949 | g(DBSNP:rs5984894) association path(MESH:"Alzheimer Disease") |
| pubmed:19136949 | g(DBSNP:rs5984894) association g(HGNC:PCDH11X) |
| pubmed:19118814 | g(HGNC:FAM13B) association path(MESH:"Alzheimer Disease") |
| pubmed:19118814 | g(HGNC:FAM13B) association g(DBSNP:rs11610206) |
| pubmed:19118814 | g(DBSNP:rs11610206) association path(MESH:"Alzheimer Disease") |
| pubmed:19118814 | g(DBSNP:rs11610206) association g(HGNC:FAM13B) |
| pubmed:18976728 | g(DBSNP:rs11159647) association path(MESH:"Alzheimer Disease") |
| pubmed:22005931 | g(HGNC:DCHS2) association path(MESH:"Alzheimer Disease") |
| pubmed:22005931 | g(HGNC:DCHS2) association g(DBSNP:rs1466662) |
| pubmed:22005931 | g(HGNC:DCHS2) association g(DBSNP:rs1466662) |
| pubmed:22005931 | g(DBSNP:rs1466662) association path(MESH:"Alzheimer Disease") |
| pubmed:22005931 | g(DBSNP:rs1466662) association g(HGNC:DCHS2) |
| pubmed:22005931 | g(DBSNP:rs1466662) association g(HGNC:DCHS2) |
| pubmed:21627779 | g(DBSNP:rs569214) association path(MESH:"Alzheimer Disease") |
| pubmed:21627779 | g(DBSNP:rs569214) association g(HGNC:CLU) |
| pubmed:21627779 | g(DBSNP:rs569214) association g(HGNC:CLU) |
| pubmed:21627779 | g(DBSNP:rs536841) association path(MESH:"Alzheimer Disease") |
| pubmed:21627779 | g(DBSNP:rs536841) association g(HGNC:PICALM) |
| pubmed:21627779 | g(DBSNP:rs536841) association g(HGNC:PICALM) |
| pubmed:21627779 | g(DBSNP:rs1562990) association path(MESH:"Alzheimer Disease") |
| pubmed:21627779 | g(DBSNP:rs1562990) association g(HGNC:MS4A6A) |
| pubmed:20061627 | g(HGNC:TOMM40) association path(MESH:"Alzheimer Disease") |
| pubmed:21123754 | g(HGNC:TOMM40) association path(MESH:"Alzheimer Disease") |
| pubmed:20061627 | g(HGNC:TOMM40) association g(DBSNP:rs2075650) |
| pubmed:21123754 | g(HGNC:TOMM40) association g(DBSNP:rs2075650) |
| pubmed:21123754 | g(HGNC:TOMM40) association g(DBSNP:rs2075650) |
| pubmed:19734902 | g(HGNC:TOMM40) association g(DBSNP:rs2075650) |
| pubmed:19734903 | g(HGNC:TOMM40) association g(DBSNP:rs2075650) |
| pubmed:20061627 | g(HGNC:TOMM40) association g(DBSNP:rs2075650) |
| pubmed:20885792 | g(HGNC:TOMM40) association g(DBSNP:rs2075650) |
| pubmed:20460622 | g(HGNC:TOMM40) association g(DBSNP:rs2075650) |
| pubmed:21627779 | g(HGNC:TOMM40) association g(DBSNP:rs157580) |
| pubmed:21123754 | g(HGNC:TOMM40) association g(DBSNP:rs157580) |
| pubmed:19125160 | g(HGNC:TOMM40) association g(DBSNP:rs157580) |
| pubmed:23419831 | g(HGNC:TOMM40) association g(DBSNP:rs59007384) |
| pubmed:21460841 | g(DBSNP:rs5616655) association path(MESH:"Alzheimer Disease") |
| pubmed:21460841 | g(DBSNP:rs5616655) association g(HGNC:PICALM) |
| pubmed:21460841 | g(HGNC:MS4A4A) association path(MESH:"Alzheimer Disease") |
| pubmed:21460841 | g(HGNC:MS4A4A) association g(DBSNP:rs4938933) |
| pubmed:21460841 | g(DBSNP:rs4938933) association path(MESH:"Alzheimer Disease") |
| pubmed:21460841 | g(DBSNP:rs4938933) association g(HGNC:MS4A4A) |
| pubmed:21460841 | g(DBSNP:rs4938933) association g(HGNC:MS4A6A) |
| pubmed:21460841 | g(DBSNP:rs7561528) association path(MESH:"Alzheimer Disease") |
| pubmed:21379329 | g(DBSNP:rs7561528) association path(MESH:"Alzheimer Disease") |
| pubmed:21460841 | g(DBSNP:rs7561528) association g(HGNC:BIN1) |
| pubmed:21379329 | g(DBSNP:rs7561528) association g(HGNC:BIN1) |
| pubmed:22832961 | g(DBSNP:rs7561528) association g(HGNC:BIN1) |
| pubmed:21460841 | g(DBSNP:rs7561528) association g(HGNC:BIN1) |
| pubmed:21460841 | g(DBSNP:rs6701713) association path(MESH:"Alzheimer Disease") |
| pubmed:21460841 | g(DBSNP:rs6701713) association g(HGNC:CR1) |
| pubmed:21460841 | g(DBSNP:rs6701713) association g(HGNC:CR1) |
| pubmed:21460841 | g(HGNC:CD2AP) association path(MESH:"Alzheimer Disease") |
| pubmed:21460841 | g(HGNC:CD2AP) association g(DBSNP:rs9349407) |
| pubmed:21460841 | g(HGNC:CD2AP) association g(DBSNP:rs9349407) |
| pubmed:24162737 | g(HGNC:CD2AP) association g(DBSNP:rs10948363) |
| pubmed:" 26517285" | g(HGNC:CD2AP) association bp(GO:endocytosis) |
| pubmed:21460841 | g(DBSNP:rs9349407) association path(MESH:"Alzheimer Disease") |
| pubmed:21460841 | g(DBSNP:rs9349407) association g(HGNC:CD2AP) |
| pubmed:21460841 | g(DBSNP:rs9349407) association g(HGNC:CD2AP) |
| pubmed:21460841 | g(HGNC:EPHA1) association path(MESH:"Alzheimer Disease") |
| pubmed:21460841 | g(HGNC:EPHA1) association g(DBSNP:rs11767557) |
| pubmed:" 26517285" | g(HGNC:EPHA1) association bp(GO:"immune response") |
| pubmed:" 26517285" | g(HGNC:EPHA1) association bp(GO:endocytosis) |
| pubmed:21460841 | g(DBSNP:rs11767557) association path(MESH:"Alzheimer Disease") |
| pubmed:21460841 | g(DBSNP:rs11767557) association g(HGNC:EPHA1) |
| pubmed:21460841 | g(DBSNP:rs1532278) association path(MESH:"Alzheimer Disease") |
| pubmed:21460841 | g(DBSNP:rs1532278) association g(HGNC:CLU) |
| pubmed:21460841 | g(DBSNP:rs1532278) association g(HGNC:CLU) |
| pubmed:21390209 | g(DBSNP:rs12989701) association path(MESH:"Alzheimer Disease") |
| pubmed:21390209 | g(DBSNP:rs12989701) association g(HGNC:BIN1) |
| pubmed:21390209 | g(DBSNP:rs12989701) association g(HGNC:BIN1) |
| pubmed:21379329 | g(HGNC:CELF2) association path(MESH:"Alzheimer Disease") |
| pubmed:21379329 | g(HGNC:CELF2) association g(DBSNP:rs201119) |
| pubmed:21379329 | g(DBSNP:rs201119) association path(MESH:"Alzheimer Disease") |
| pubmed:21379329 | g(DBSNP:rs201119) association g(HGNC:CELF2) |
| pubmed:20885792 | g(HGNC:MTHFD1L) association path(MESH:"Alzheimer Disease") |
| pubmed:20885792 | g(HGNC:MTHFD1L) association g(DBSNP:rs11754661) |
| pubmed:20885792 | g(HGNC:MTHFD1L) association g(DBSNP:rs11754661) |
| pubmed:20885792 | g(DBSNP:rs11754661) association path(MESH:"Alzheimer Disease") |
| pubmed:20885792 | g(DBSNP:rs11754661) association g(HGNC:MTHFD1L) |
| pubmed:20885792 | g(DBSNP:rs11754661) association g(HGNC:MTHFD1L) |
| pubmed:17553421 | g(DBSNP:rs2373115) association path(MESH:"Alzheimer Disease") |
| pubmed:17553421 | g(DBSNP:rs2373115) association g(HGNC:GAB2) |
| pubmed:17553421 | g(DBSNP:rs2373115) association g(HGNC:GAB2) |
| pubmed:21123754 | g(HGNC:EPC2) association path(MESH:"Alzheimer Disease") |
| pubmed:21123754 | g(HGNC:EPC2) association g(DBSNP:rs4499362) |
| pubmed:21123754 | g(HGNC:EPC2) association g(DBSNP:rs4499362) |
| pubmed:21123754 | g(HGNC:EPC2) association g(DBSNP:rs2121433) |
| pubmed:21123754 | g(DBSNP:rs4499362) association path(MESH:"Alzheimer Disease") |
| pubmed:21123754 | g(DBSNP:rs4499362) association g(HGNC:EPC2) |
| pubmed:21123754 | g(DBSNP:rs4499362) association g(HGNC:EPC2) |
| pubmed:21123754 | g(HGNC:CCDC134) association path(MESH:"Alzheimer Disease") |
| pubmed:21123754 | g(HGNC:CCDC134) association g(DBSNP:rs7364180) |
| pubmed:21123754 | g(HGNC:CCDC134) association g(DBSNP:rs7364180) |
| pubmed:21123754 | g(DBSNP:rs7364180) association path(MESH:"Alzheimer Disease") |
| pubmed:21123754 | g(DBSNP:rs7364180) association g(HGNC:CCDC134) |
| pubmed:21123754 | g(DBSNP:rs7364180) association g(HGNC:CCDC134) |
| pubmed:23022416 | composite(g(DBSNP:rs3818361), g(DBSNP:rs429358)) association path(MESH:"Alzheimer Disease") |
| pubmed:22236693 | p(HGNC:NTRK1) negativeCorrelation bp(GO:"apoptotic process") |
| pubmed:18986241 | p(HGNC:NTRK1) negativeCorrelation path(MESH:"Cognition Disorders") |
| pubmed:18986241 | p(HGNC:NTRK1) biomarkerFor path(MESH:"Alzheimer Disease") |
| pubmed:18986241 | p(HGNC:NTRK1) decreases act(p(HGNC:BACE1)) |
| pubmed:18986241 | complex(p(HGNC:NGF), p(HGNC:NGFR)) increases complex(p(HGNC:NGF), p(HGNC:NTRK1)) |
| pubmed:22236693 | bp(GO:"regulation of cell death") association p(HGNC:NGFR) |
| pubmed:22236693 | g(HGNC:NGFR) association g(DBSNP:rs2072446) |
| pubmed:22236693 | g(HGNC:NGFR) association g(DBSNP:rs741072) |
| pubmed:22236693 | g(HGNC:NGFR) association g(DBSNP:rs2072445) |
| pubmed:22236693 | g(HGNC:NGFR) association g(DBSNP:rs734194) |
| pubmed:22236693 | g(HGNC:NGFR) negativeCorrelation bp(GO:cognition) |
| pubmed:22236693 | g(HGNC:NGFR) association path(MESH:Dementia) |
| pubmed:22236693 | g(HGNC:NGFR) increases bp(GO:"apoptotic process") |
| pubmed:22236693 | g(DBSNP:rs2072446) association g(HGNC:NGFR) |
| pubmed:22236693 | g(DBSNP:rs2072446) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22236693 | g(DBSNP:rs2072446) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22236693 | g(DBSNP:rs741072) association g(HGNC:NGFR) |
| pubmed:22236693 | g(DBSNP:rs741072) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22236693 | g(DBSNP:rs2072445) association g(HGNC:NGFR) |
| pubmed:22236693 | g(DBSNP:rs734194) association g(HGNC:NGFR) |
| pubmed:22236693 | g(DBSNP:rs734194) decreases act(g(HGNC:NGFR)) |
| pubmed:22236693 | g(DBSNP:rs734194) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22236693 | g(DBSNP:rs734194) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22236693 | g(DBSNP:rs734194) association bp(GO:"regulation of mRNA stability") |
| pubmed:22236693 | g(DBSNP:rs734194) association bp(GO:"regulation of translation") |
| pubmed:22236693 | g(DBSNP:rs734194) decreases complex(p(HGNC:NGF), p(HGNC:NGFR)) |
| pubmed:22236693 | g(DBSNP:rs734194) decreases complex(p(HGNC:APP, frag("672_713")), p(HGNC:NGFR)) |
| pubmed:22236693 | g(DBSNP:rs734194) decreases p(HGNC:NGFR) |
| pubmed:22236693 | g(RGD:Ngfr) association path(MESH:"Diabetes Mellitus, Type 2") |
| pubmed:22236693 | complex(p(HGNC:APP, frag("672_713")), p(HGNC:NGFR)) increases bp(GO:"apoptotic process") |
| pubmed:22236693 | bp(GO:"regulation of mRNA stability") association g(DBSNP:rs734194) |
| pubmed:22236693 | bp(GO:"regulation of translation") association g(DBSNP:rs734194) |
| pubmed:" 21047645" | m(HGNC:MIR659) decreases r(HGNC:GRN) |
| pubmed:" 21047645" | r(HGNC:GRN) association g(DBSNP:rs5848) |
| pubmed:19625741 | r(HGNC:GRN) increases p(HGNC:GRN) |
| pubmed:" 21047645" | g(DBSNP:rs5848) association r(HGNC:GRN) |
| pubmed:19625741 | p(HGNC:GRN) positiveCorrelation bp(GO:"neuron death") |
| pubmed:30116051 | p(HGNC:GRN) increases act(p(HGNC:MME)) |
| pubmed:30116051 | p(HGNC:GRN) decreases path(MESH:"Plaque, Amyloid") |
| pubmed:29183403 | g(DBSNP:rs142787485) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29183403 | p(HGNC:RAB10) increases p(HGNC:APP, frag("672_713")) |
| pubmed:29183403 | p(HGNC:RAB10) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21709374 | g(DBSNP:rs1050283) association g(HGNC:OLR1) |
| pubmed:21709374 | g(DBSNP:rs1050283) association path(MESH:"Alzheimer Disease") |
| pubmed:18191876 | g(DBSNP:rs1050283) association path(MESH:"Alzheimer Disease") |
| pubmed:21709374 | g(HGNC:OLR1) association g(DBSNP:rs1050283) |
| pubmed:21709374 | g(HGNC:OLR1) increases r(HGNC:OLR1) |
| pubmed:21709374 | m(HGNC:MIR369) association r(HGNC:OLR1) |
| pubmed:21709374 | r(HGNC:OLR1) association m(HGNC:MIR369) |
| pubmed:21709374 | r(HGNC:OLR1) increases p(HGNC:OLR1) |
| pubmed:18191876 | g(HGNC:A2M) causesNoChange path(MESH:"Alzheimer Disease") |
| pubmed:18191876 | g(DBSNP:rs12316150) association path(MESH:"Alzheimer Disease") |
| pubmed:19660836 | g(DBSNP:rs4135263) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19660836 | g(DBSNP:rs4135263) association g(HGNC:PPARG) |
| pubmed:19660836 | g(DBSNP:rs1151999) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19660836 | g(DBSNP:rs1151999) association g(HGNC:PPARG) |
| pubmed:19660836 | g(DBSNP:rs709149) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19660836 | g(DBSNP:rs709149) association g(HGNC:PPARG) |
| pubmed:19660836 | g(DBSNP:rs709154) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19660836 | g(DBSNP:rs709154) association g(HGNC:PPARG) |
| pubmed:19660836 | g(HGNC:PPARG) association path(MESH:"Alzheimer Disease") |
| pubmed:19660836 | g(HGNC:PPARG) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19660836 | g(HGNC:PPARG) increases r(HGNC:PPARG) |
| pubmed:19660836 | g(HGNC:PPARG) association g(DBSNP:rs4135263) |
| pubmed:19660836 | g(HGNC:PPARG) association g(DBSNP:rs1151999) |
| pubmed:19660836 | g(HGNC:PPARG) association g(DBSNP:rs709149) |
| pubmed:19660836 | g(HGNC:PPARG) association g(DBSNP:rs709154) |
| pubmed:21548758 | m(HGNC:MIR590) association g(HGNC:HNRNPA1) |
| pubmed:21548758 | g(HGNC:HNRNPA1) association m(HGNC:MIR590) |
| pubmed:21548758 | g(HGNC:HNRNPA1) association g(DBSNP:rs7967622) |
| pubmed:21548758 | g(HGNC:HNRNPA1) association path(MESH:"Alzheimer Disease") |
| pubmed:21548758 | g(DBSNP:rs7967622) association g(HGNC:HNRNPA1) |
| pubmed:24162737 | g(DBSNP:rs10792832) association g(HGNC:PICALM) |
| pubmed:24162737 | g(DBSNP:rs6733839) association g(HGNC:BIN1) |
| pubmed:24162737 | g(DBSNP:rs10948363) association g(HGNC:CD2AP) |
| pubmed:24162737 | g(DBSNP:rs11218343) association g(HGNC:SORL1) |
| pubmed:23565137 | g(DBSNP:rs11218343) association g(HGNC:SORL1) |
| pubmed:24162737 | g(DBSNP:rs4147929) association g(HGNC:ABCA7) |
| pubmed:24162737 | g(DBSNP:rs72807343) association g(HGNC:SQSTM1) |
| pubmed:24162737 | g(HGNC:SQSTM1) association g(DBSNP:rs72807343) |
| pubmed:24162737 | g(HGNC:SQSTM1) association path(MESH:"Alzheimer Disease") |
| pubmed:24162737 | g(DBSNP:rs9331896) association g(HGNC:CLU) |
| pubmed:22832961 | g(DBSNP:rs17817600) association g(HGNC:PICALM) |
| pubmed:22005930 | g(DBSNP:rs10792830) association g(HGNC:PICALM) |
| pubmed:22005930 | g(DBSNP:rs10207628) association g(HGNC:BIN1) |
| pubmed:21627779 | g(DBSNP:rs157580) association g(HGNC:TOMM40) |
| pubmed:21123754 | g(DBSNP:rs157580) association g(HGNC:TOMM40) |
| pubmed:19125160 | g(DBSNP:rs157580) association g(HGNC:TOMM40) |
| pubmed:21460841 | g(DBSNP:rs561655) association g(HGNC:PICALM) |
| pubmed:21460841 | g(DBSNP:rs3752246) association g(HGNC:ABCA7) |
| pubmed:23556446 | g(DBSNP:rs3752246) association path(MESH:"Alzheimer Disease") |
| pubmed:21390209 | g(DBSNP:rs3934834) association g(HGNC:AGRN) |
| pubmed:21390209 | g(HGNC:AGRN) association g(DBSNP:rs3934834) |
| pubmed:21390209 | g(HGNC:AGRN) association path(MESH:"Alzheimer Disease") |
| pubmed:21123754 | g(DBSNP:rs2121433) association g(HGNC:EPC2) |
| pubmed:21123754 | g(DBSNP:rs439401) association g(HGNC:APOE) |
| pubmed:19734902 | g(DBSNP:rs10052694) association g(HGNC:MIR146A) |
| pubmed:19734902 | g(HGNC:MIR146A) association g(DBSNP:rs10052694) |
| pubmed:19734902 | g(HGNC:MIR146A) association path(MESH:"Alzheimer Disease") |
| pubmed:24586483 | g(HGNC:MIR146A) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(HGNC:MIR146A) association g(DBSNP:rs4921144) |
| pubmed:19734902 | g(HGNC:MIR146A) association g(DBSNP:rs9313850) |
| pubmed:24586483 | g(HGNC:MIR146A) decreases bp(GO:cognition) |
| pubmed:19734902 | g(DBSNP:rs12090333) association g(HGNC:CSF3R) |
| pubmed:19734902 | g(HGNC:CSF3R) association g(DBSNP:rs12090333) |
| pubmed:19734902 | g(HGNC:CSF3R) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(DBSNP:rs12099529) association g(HGNC:NAV3) |
| pubmed:19734902 | g(HGNC:NAV3) association g(DBSNP:rs12099529) |
| pubmed:19734902 | g(HGNC:NAV3) association g(DBSNP:rs1795977) |
| pubmed:19734902 | g(HGNC:NAV3) association g(DBSNP:rs2710922) |
| pubmed:19734902 | g(HGNC:NAV3) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(DBSNP:rs17234657) association g(HGNC:DAB2) |
| pubmed:19734902 | g(HGNC:DAB2) association g(DBSNP:rs17234657) |
| pubmed:19734902 | g(HGNC:DAB2) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(HGNC:DAB1) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(HGNC:DAB1) association g(DBSNP:rs11206955) |
| pubmed:19734902 | g(HGNC:DAB1) association g(DBSNP:rs11810899) |
| pubmed:19734902 | g(HGNC:DAB1) association g(DBSNP:rs12035887) |
| pubmed:19734902 | g(HGNC:DAB1) association g(DBSNP:rs3754268) |
| pubmed:19734902 | g(DBSNP:rs1795977) association g(HGNC:NAV3) |
| pubmed:19734902 | g(DBSNP:rs197196) association g(HGNC:BTBD3) |
| pubmed:19734902 | g(HGNC:BTBD3) association g(DBSNP:rs197196) |
| pubmed:19734902 | g(HGNC:BTBD3) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(DBSNP:rs2264802) association g(HGNC:SKAP2) |
| pubmed:19734902 | g(HGNC:SKAP2) association g(DBSNP:rs2264802) |
| pubmed:19734902 | g(HGNC:SKAP2) association g(DBSNP:rs2462910) |
| pubmed:19734902 | g(HGNC:SKAP2) association g(DBSNP:rs2465271) |
| pubmed:19734902 | g(HGNC:SKAP2) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(DBSNP:rs2462910) association g(HGNC:SKAP2) |
| pubmed:19734902 | g(DBSNP:rs2465271) association g(HGNC:SKAP2) |
| pubmed:19734902 | g(DBSNP:rs2710922) association g(HGNC:NAV3) |
| pubmed:19734902 | g(DBSNP:rs4921144) association g(HGNC:MIR146A) |
| pubmed:19734902 | g(DBSNP:rs527384) association g(HGNC:MKI67) |
| pubmed:19734902 | g(HGNC:MKI67) association g(DBSNP:rs527384) |
| pubmed:19734902 | g(HGNC:MKI67) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(HGNC:MKI67) association g(DBSNP:rs540879) |
| pubmed:19734902 | g(HGNC:MKI67) association g(DBSNP:rs541392) |
| pubmed:19734902 | g(DBSNP:rs540879) association g(HGNC:MKI67) |
| pubmed:19734902 | g(DBSNP:rs541392) association g(HGNC:MKI67) |
| pubmed:19734902 | g(DBSNP:rs639446) association g(HGNC:ANXA1) |
| pubmed:19734902 | g(HGNC:ANXA1) association g(DBSNP:rs639446) |
| pubmed:19734902 | g(HGNC:ANXA1) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(DBSNP:rs7023075) association g(HGNC:SPTLC1) |
| pubmed:19734902 | g(HGNC:SPTLC1) association g(DBSNP:rs7023075) |
| pubmed:19734902 | g(HGNC:SPTLC1) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(DBSNP:rs7467550) association g(HGNC:GRIN3A) |
| pubmed:19734902 | g(HGNC:GRIN3A) association g(DBSNP:rs7467550) |
| pubmed:19734902 | g(HGNC:GRIN3A) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(HGNC:GRIN3A) association g(DBSNP:rs843287) |
| pubmed:19734902 | g(HGNC:GRIN3A) association g(DBSNP:rs860935) |
| pubmed:19734902 | g(DBSNP:rs7668921) association g(HGNC:STIM2) |
| pubmed:19734902 | g(HGNC:STIM2) association g(DBSNP:rs7668921) |
| pubmed:19734902 | g(HGNC:STIM2) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(DBSNP:rs843287) association g(HGNC:GRIN3A) |
| pubmed:19734902 | g(DBSNP:rs860935) association g(HGNC:GRIN3A) |
| pubmed:19734902 | g(DBSNP:rs9313850) association g(HGNC:MIR146A) |
| pubmed:19734902 | g(DBSNP:rs9404493) association g(HGNC:GRIK2) |
| pubmed:19734902 | g(HGNC:GRIK2) association g(DBSNP:rs9404493) |
| pubmed:19734902 | g(HGNC:GRIK2) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(DBSNP:rs10084692) association g(HGNC:ROBO2) |
| pubmed:19734902 | g(HGNC:ROBO2) association g(DBSNP:rs10084692) |
| pubmed:19734902 | g(HGNC:ROBO2) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(HGNC:ROBO2) association g(DBSNP:rs9309766) |
| pubmed:19734902 | g(HGNC:ROBO2) association g(DBSNP:rs9818075) |
| pubmed:19734902 | g(DBSNP:rs10925500) association g(HGNC:RYR2) |
| pubmed:19734902 | g(HGNC:RYR2) association g(DBSNP:rs10925500) |
| pubmed:19734902 | g(HGNC:RYR2) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(DBSNP:rs11206955) association g(HGNC:DAB1) |
| pubmed:19734902 | g(DBSNP:rs11810899) association g(HGNC:DAB1) |
| pubmed:19734902 | g(DBSNP:rs12035887) association g(HGNC:DAB1) |
| pubmed:19734902 | g(DBSNP:rs1217338) association g(HGNC:APBA1) |
| pubmed:19734902 | g(HGNC:APBA1) association g(DBSNP:rs1217338) |
| pubmed:19734902 | g(HGNC:APBA1) association g(DBSNP:rs7866199) |
| pubmed:19734902 | g(HGNC:APBA1) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(DBSNP:rs12212067) association g(HGNC:FOXO3) |
| pubmed:19734902 | g(HGNC:FOXO3) association g(DBSNP:rs12212067) |
| pubmed:19734902 | g(HGNC:FOXO3) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(DBSNP:rs17105095) association g(HGNC:SLC25A21) |
| pubmed:19734902 | g(HGNC:SLC25A21) association g(DBSNP:rs17105095) |
| pubmed:19734902 | g(HGNC:SLC25A21) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(HGNC:SLC25A21) association g(DBSNP:rs17105125) |
| pubmed:19734902 | g(HGNC:SLC25A21) association g(DBSNP:rs17105164) |
| pubmed:19734902 | g(DBSNP:rs17105125) association g(HGNC:SLC25A21) |
| pubmed:19734902 | g(DBSNP:rs17105164) association g(HGNC:SLC25A21) |
| pubmed:19734902 | g(DBSNP:rs2596163) association g(HGNC:RYR3) |
| pubmed:19734902 | g(HGNC:RYR3) association g(DBSNP:rs2596163) |
| pubmed:19734902 | g(HGNC:RYR3) association g(DBSNP:rs2676087) |
| pubmed:19734902 | g(HGNC:RYR3) association g(DBSNP:rs8026464) |
| pubmed:19734902 | g(HGNC:RYR3) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(DBSNP:rs2676087) association g(HGNC:RYR3) |
| pubmed:19734902 | g(DBSNP:rs362769) association g(HGNC:RELN) |
| pubmed:19734902 | g(HGNC:RELN) association g(DBSNP:rs362769) |
| pubmed:19734902 | g(HGNC:RELN) association path(MESH:"Alzheimer Disease") |
| pubmed:20452100 | g(HGNC:RELN) association g(DBSNP:rs4298437) |
| pubmed:19734902 | g(DBSNP:rs3754268) association g(HGNC:DAB1) |
| pubmed:19734902 | g(DBSNP:rs540787) association g(HGNC:GRIK4) |
| pubmed:19734902 | g(HGNC:GRIK4) association g(DBSNP:rs540787) |
| pubmed:19734902 | g(HGNC:GRIK4) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(DBSNP:rs754107) association g(HGNC:BIN1) |
| pubmed:19734902 | g(DBSNP:rs7866199) association g(HGNC:APBA1) |
| pubmed:19734902 | g(DBSNP:rs8026464) association g(HGNC:RYR3) |
| pubmed:19734902 | g(DBSNP:rs8064630) association g(HGNC:ATP2A3) |
| pubmed:19734902 | g(HGNC:ATP2A3) association g(DBSNP:rs8064630) |
| pubmed:19734902 | g(HGNC:ATP2A3) association path(MESH:"Alzheimer Disease") |
| pubmed:19734902 | g(DBSNP:rs9309766) association g(HGNC:ROBO2) |
| pubmed:19734902 | g(DBSNP:rs9818075) association g(HGNC:ROBO2) |
| pubmed:23571587 | g(DBSNP:rs115550680) association g(HGNC:ABCA7) |
| pubmed:23565137 | g(DBSNP:rs519113) association g(HGNC:NECTIN2) |
| pubmed:23565137 | g(HGNC:NECTIN2) association g(DBSNP:rs519113) |
| pubmed:23419831 | g(HGNC:NECTIN2) association g(DBSNP:rs6857) |
| pubmed:22005931 | g(HGNC:NECTIN2) association g(DBSNP:rs6857) |
| pubmed:22159054 | g(HGNC:NECTIN2) association g(DBSNP:rs6859) |
| pubmed:18823527 | g(HGNC:NECTIN2) association g(DBSNP:rs6859) |
| pubmed:20885792 | g(HGNC:NECTIN2) association g(DBSNP:rs6859) |
| pubmed:23562540 | g(DBSNP:rs769449) association g(HGNC:APOE) |
| pubmed:23535033 | g(DBSNP:rs77636885) association g(HGNC:CAMK4) |
| pubmed:23535033 | g(HGNC:CAMK4) association g(DBSNP:rs77636885) |
| pubmed:23535033 | g(HGNC:CAMK4) association path(MESH:"Alzheimer Disease") |
| pubmed:23535033 | g(DBSNP:rs1861525) association g(HGNC:CYCS) |
| pubmed:23535033 | g(HGNC:CYCS) association g(DBSNP:rs1861525) |
| pubmed:23535033 | g(HGNC:CYCS) association path(MESH:"Alzheimer Disease") |
| pubmed:23419831 | g(DBSNP:rs59007384) association g(HGNC:TOMM40) |
| pubmed:23419831 | g(DBSNP:rs6857) association g(HGNC:NECTIN2) |
| pubmed:22005931 | g(DBSNP:rs6857) association g(HGNC:NECTIN2) |
| pubmed:22430674 | g(DBSNP:rs17314229) association g(HGNC:FRMD4A) |
| pubmed:22430674 | g(HGNC:FRMD4A) association g(DBSNP:rs17314229) |
| pubmed:22430674 | g(HGNC:FRMD4A) association g(DBSNP:rs2446581) |
| pubmed:22430674 | g(HGNC:FRMD4A) association g(DBSNP:rs7081208) |
| pubmed:22430674 | g(DBSNP:rs2446581) association g(HGNC:FRMD4A) |
| pubmed:22430674 | g(DBSNP:rs7081208) association g(HGNC:FRMD4A) |
| pubmed:19136949 | g(DBSNP:rs2573905) association g(HGNC:PCDH11X) |
| pubmed:19734903 | g(DBSNP:rs2279590) association g(HGNC:CLU) |
| pubmed:20452100 | g(DBSNP:rs4298437) association g(HGNC:RELN) |
| pubmed:22107728 | g(DBSNP:rs4646953) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22107728 | g(DBSNP:rs4646953) positiveCorrelation p(HGNC:APP, frag("672_713")) |
| pubmed:22107728 | g(DBSNP:rs2251101) association path(MESH:"Diabetes Mellitus, Type 2") |
| pubmed:22107728 | g(DBSNP:rs1887922) causesNoChange path(MESH:"Alzheimer Disease") |
| pubmed:22107728 | g(DBSNP:rs1887922) causesNoChange path(MESH:"Diabetes Mellitus, Type 2") |
| pubmed:23279143 | p(HGNC:SORCS1) association path(MESH:"Alzheimer Disease") |
| pubmed:23279143 | p(HGNC:SORCS1) association path(MESH:"Diabetes Mellitus, Type 2") |
| pubmed:25570489 | p(HGNC:SORCS1) association a(NIFT:"Ventricular expansion") |
| pubmed:23279143 | r(HGNC:SORCS1) decreases p(HGNC:APP, frag("672_713")) |
| pubmed:23279143 | g(HGNC:SORCS1) association g(DBSNP:rs7907690) |
| pubmed:23279143 | g(DBSNP:rs7907690) association g(HGNC:SORCS1) |
| pubmed:23279143 | g(DBSNP:rs7907690) association path(MESH:"Alzheimer Disease") |
| pubmed:23279143 | g(DBSNP:rs7907690) association path(MESH:"Alzheimer Disease") |
| pubmed:23279143 | g(DBSNP:rs7907690) association path(MESH:"Diabetes Mellitus, Type 2") |
| pubmed:23279143 | g(DBSNP:rs601883) association path(MESH:"Alzheimer Disease") |
| pubmed:23279143 | g(DBSNP:rs17277986) association path(MESH:"Alzheimer Disease") |
| pubmed:23279143 | g(DBSNP:rs2900717) association path(MESH:"Alzheimer Disease") |
| pubmed:23279143 | g(DBSNP:rs10884399) association path(MESH:"Alzheimer Disease") |
| pubmed:23279143 | g(DBSNP:rs11193170) association path(MESH:"Alzheimer Disease") |
| pubmed:23279143 | g(DBSNP:rs4918280) association path(MESH:"Alzheimer Disease") |
| pubmed:23279143 | g(DBSNP:rs600879) association path(MESH:"Alzheimer Disease") |
| pubmed:23403532 | complex(p(HGNC:NRXN2), p(INTERPRO:Neuroligin)) increases bp(GO:"synapse assembly") |
| pubmed:23403532 | complex(p(HGNC:NRXN2), p(INTERPRO:Neuroligin)) association path(MESH:"Alzheimer Disease") |
| pubmed:23403532 | complex(p(HGNC:NRXN3), p(INTERPRO:Neuroligin)) increases bp(GO:"synapse assembly") |
| pubmed:23403532 | complex(p(HGNC:NRXN3), p(INTERPRO:Neuroligin)) association path(MESH:"Alzheimer Disease") |
| pubmed:23403532 | complex(p(HGNC:NRXN1), p(INTERPRO:Neuroligin)) increases bp(GO:"synapse assembly") |
| pubmed:23403532 | complex(p(HGNC:NRXN1), p(INTERPRO:Neuroligin)) association path(MESH:"Alzheimer Disease") |
| pubmed:23403532 | g(HGNC:NRXN3) association g(DBSNP:rs17757879) |
| pubmed:23403532 | g(DBSNP:rs17757879) association g(HGNC:NRXN3) |
| pubmed:23403532 | g(DBSNP:rs17757879) decreases path(MESH:"Alzheimer Disease") |
| pubmed:21036197 | g(DBSNP:rs411280) association g(HGNC:NTM) |
| pubmed:21036197 | g(DBSNP:rs411280) association path(MESH:"Alzheimer Disease") |
| pubmed:21036197 | g(HGNC:NTM) association g(DBSNP:rs411280) |
| pubmed:21036197 | g(DBSNP:rs3846329) association g(HGNC:NR3C2) |
| pubmed:21036197 | g(HGNC:NR3C2) association g(DBSNP:rs3846329) |
| pubmed:21036197 | g(HGNC:NR3C2) association bp(GO:cognition) |
| pubmed:24586483 | bp(GO:"amyloid precursor protein metabolic process") association m(HGNC:MIR146A) |
| pubmed:25038421 | g(DBSNP:rs998382) association g(HGNC:DNMT3B) |
| pubmed:25038421 | g(DBSNP:rs998382) association path(MESH:"Alzheimer Disease") |
| pubmed:25038421 | g(HGNC:DNMT3B) association g(DBSNP:rs998382) |
| pubmed:25038421 | g(HGNC:DNMT3B) association g(DBSNP:rs2424913) |
| pubmed:25038421 | g(DBSNP:rs2424913) association g(HGNC:DNMT3B) |
| pubmed:25038421 | g(DBSNP:rs2424913) association path(MESH:"Alzheimer Disease") |
| pubmed:22272627 | g(DBSNP:rs2424913) increases path(EFO:"late-onset Alzheimers disease") |
| pubmed:22272627 | g(HGNC:DNMT3B, var("c.149C>T")) increases path(EFO:"late-onset Alzheimers disease") |
| pubmed:22272627 | g(HGNC:DNMT3B, var("c.79G>T")) increases path(EFO:"late-onset Alzheimers disease") |
| pubmed:22272627 | g(DBSNP:rs1569686) increases path(EFO:"late-onset Alzheimers disease") |
| pubmed:22691691 | g(DBSNP:rs1569686) increases g(HGNC:DRD4, gmod(go:0006306 ! "DNA methylation")) |
| pubmed:22691691 | g(HGNC:DRD4) increases p(HGNC:DRD4) |
| pubmed:22691691 | g(DBSNP:rs752306) increases g(HGNC:DRD4, gmod(go:0006306 ! "DNA methylation")) |
| pubmed:22691691 | g(DBSNP:rs11246228) increases g(HGNC:DRD4, gmod(go:0006306 ! "DNA methylation")) |
| pubmed:22691691 | g(DBSNP:rs936465) increases g(HGNC:DRD4, gmod(go:0006306 ! "DNA methylation")) |
| pubmed:22691691 | p(HGNC:DRD4) association g(DBSNP:rs3758653) |
| pubmed:22691691 | p(HGNC:DRD4) association path(MESH:"Alzheimer Disease") |
| pubmed:22691691 | g(DBSNP:rs3758653) association p(HGNC:DRD4) |
| pubmed:25800888 | g(DBSNP:rs17070145) association p(HGNC:WWC1) |
| pubmed:27004735 | p(HGNC:TOMM40) association g(DBSNP:rs2075650) |
| pubmed:25862420 | p(HGNC:TOMM40) decreases a(NIFT:"Cortical Thickness") |
| pubmed:22550605 | p(HGNC:TOMM40) increases tloc(p(HGNC:APP, frag("672_713")), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:" 26517285" | bp(GO:"lipid transport") association g(HGNC:CLU) |
| pubmed:" 26517285" | bp(GO:"lipid transport") association g(HGNC:ABCA7) |
| pubmed:" 26517285" | bp(GO:"lipid metabolic process") association g(HGNC:SORL1) |
| pubmed:" 26517285" | bp(GO:"lipid metabolic process") association g(HGNC:PICALM) |
| pubmed:19293145 | bp(GO:"lipid metabolic process") association p(HGNC:APOE) |
| pubmed:19293145 | bp(GO:"lipid metabolic process") association p(HGNC:CHRNA4) |
| pubmed:22142809 | bp(GO:"lipid metabolic process") association p(HGNC:CAV2) |
| pubmed:" 26517285" | g(HGNC:TREM2) increases path(MESH:"Alzheimer Disease") |
| pubmed:" 26517285" | g(DBSNP:rs3824968) association g(HGNC:CLU) |
| pubmed:" 26517285" | g(DBSNP:rs3824968) increases g(HGNC:CLU) |
| pubmed:" 26517285" | g(DBSNP:rs3824968) association bp(GO:"microglial cell activation") |
| pubmed:" 26517285" | g(DBSNP:rs3824968) association bp(GO:"complement activation") |
| pubmed:26996954 | g(DBSNP:rs3824968) association p(HGNC:SORL1) |
| pubmed:26996954 | g(DBSNP:rs3824968) association g(HGNC:SORL1) |
| pubmed:26996954 | g(DBSNP:rs3824968) association g(HGNC:SORL1) |
| pubmed:26996954 | g(DBSNP:rs3824968) negativeCorrelation a(NIFT:"Grey matter volume") |
| pubmed:26996954 | g(DBSNP:rs3824968) association path(MESH:"Amyloid Neuropathies") |
| pubmed:26996954 | g(DBSNP:rs3824968) association a(NIFT:"Brain volume") |
| pubmed:26996954 | g(DBSNP:rs3824968) association a(NIFT:"White Matter Hyperintensity") |
| pubmed:26996954 | g(DBSNP:rs3824968) increases act(a(CHEBI:amyloid-beta)) |
| pubmed:26996954 | g(DBSNP:rs3824968) association path(MESH:"Cerebrovascular Disorders") |
| pubmed:22950410 | g(DBSNP:rs1800547) increases g(HGNC:LRRC37A4P) |
| pubmed:22950410 | g(DBSNP:rs1800547) increases p(HGNC:MAPT) |
| pubmed:22950410 | g(DBSNP:rs1800547) decreases g(HGNC:ARF2P) |
| pubmed:22950410 | g(DBSNP:rs1800547) decreases p(HGNC:LRRC37A) |
| pubmed:22950410 | g(DBSNP:rs1800547) decreases p(HGNC:CRHR1) |
| pubmed:22950410 | g(DBSNP:rs1800547) increases p(HGNC:CRHR1) |
| pubmed:22950410 | p(HGNC:CRHR1) association path(MESH:Depression) |
| pubmed:22950410 | p(HGNC:CRHR1) increases path(MESH:Depression) |
| pubmed:22950410 | p(HGNC:CRHR1) association path(MESH:Anxiety) |
| pubmed:22950410 | p(HGNC:CRHR1) increases path(MESH:Anxiety) |
| pubmed:22950410 | p(HGNC:CRHR1) association path(MESH:Alcoholism) |
| pubmed:22950410 | p(HGNC:CRHR1) increases path(MESH:Alcoholism) |
| pubmed:22950410 | p(HGNC:CRHR1) association path(MESH:"Multiple Sclerosis") |
| pubmed:25687773 | p(HGNC:CRHR1) association g(DBSNP:rs393152) |
| pubmed:25687773 | p(HGNC:CRHR1) association g(DBSNP:rs393152) |
| pubmed:22950410 | path(MESH:Alcoholism) association p(HGNC:CRHR1) |
| pubmed:26979166 | path(MESH:Alcoholism) positiveCorrelation path(MESH:Depression) |
| pubmed:26979166 | path(MESH:Alcoholism) positiveCorrelation path(DOID:"bipolar disorder") |
| pubmed:21482353 | path(MESH:Alcoholism) positiveCorrelation p(HGNC:CHRNA5, var("?")) |
| pubmed:21482353 | path(MESH:Alcoholism) positiveCorrelation p(HGNC:CHRNA3, var("?")) |
| pubmed:21482353 | path(MESH:Alcoholism) positiveCorrelation p(HGNC:CHRNB4, var("?")) |
| pubmed:25687773 | g(DBSNP:rs393152) association p(HGNC:CRHR1) |
| pubmed:25687773 | g(DBSNP:rs393152) association p(HGNC:CRHR1) |
| pubmed:25687773 | g(DBSNP:rs393152) association path(MESH:Atrophy) |
| pubmed:25687773 | g(DBSNP:rs393152) positiveCorrelation path(MESH:Atrophy) |
| pubmed:25687773 | g(DBSNP:rs393152) association path(MESH:"Alzheimer Disease") |
| pubmed:25687773 | g(DBSNP:rs393152) association path(MESH:"Alzheimer Disease") |
| pubmed:25687773 | g(DBSNP:rs393152) increases p(HGNC:MAPT) |
| pubmed:25687773 | g(DBSNP:rs393152) association bp(GO:"neurofibrillary tangle assembly") |
| pubmed:19419557 | p(HGNC:CALB1) increases bp(GO:"calcium ion transport") |
| pubmed:25514383 | bp(GO:"calcium ion transport") negativeCorrelation p(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:25514383 | bp(GO:"calcium ion transport") positiveCorrelation a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pubmed:21482353 | bp(GO:"calcium ion transport") association act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:19419557 | p(FPLX:"CAMK2_family") increases bp(GO:"calcium ion transport") |
| pubmed:2833519 | act(p(FPLX:"CAMK2_family")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19419557 | p(HGNC:PVALB) increases bp(GO:"calcium ion transport") |
| pubmed:19419557 | a(CHEBI:"glutamate(2-)") association bp(GO:"synaptic transmission, glutamatergic") |
| pubmed:19419557 | a(CHEBI:"glutamate(2-)") association p(MESH:"Receptors, Ionotropic Glutamate") |
| pubmed:19419557 | a(CHEBI:"glutamate(2-)") association p(HGNCGENEFAMILY:"Glutamate metabotropic receptors") |
| pubmed:19126755 | a(CHEBI:"glutamate(2-)", loc(MESH:"Dopaminergic Neurons")) increases bp(GO:"synaptic transmission, dopaminergic") |
| pubmed:19293145 | act(a(CHEBI:"glutamate(2-)")) increases path(CONSO:Excitotoxicity) |
| pubmed:22530628 | act(a(CHEBI:"glutamate(2-)")) increases path(CONSO:Excitotoxicity) |
| pubmed:17009926 | tloc(a(CHEBI:"glutamate(2-)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases bp(GO:"long-term synaptic potentiation") |
| pubmed:16273023 | a(CHEBI:"glutamate(2-)") directlyIncreases bp(GO:"GO:0014047") |
| pubmed:16273023 | a(CHEBI:"glutamate(2-)") directlyIncreases act(p(MESH:D017470)) |
| pubmed:30697142 | a(CHEBI:"glutamate(2-)") regulates bp(GO:"learning or memory") |
| pubmed:30697142 | a(CHEBI:"glutamate(2-)") increases bp(MESH:"Neuronal Plasticity") |
| pubmed:19419557 | p(MESH:"Receptors, Ionotropic Glutamate") association a(CHEBI:"glutamate(2-)") |
| pubmed:19419557 | p(MESH:"Receptors, Ionotropic Glutamate") increases path(CONSO:Excitotoxicity) |
| pubmed:19419557 | p(MESH:"Receptors, Ionotropic Glutamate") increases tloc(a(MESH:Calcium), fromLoc(MESH:"Cell Membrane"), toLoc(GO:intracellular)) |
| pubmed:19419557 | p(MESH:"Receptors, Ionotropic Glutamate") decreases act(p(MESH:"Calcium Channels")) |
| pubmed:19419557 | p(MESH:"Receptors, Ionotropic Glutamate") increases bp(GO:"calcium ion import") |
| pubmed:19419557 | p(MESH:"Receptors, Ionotropic Glutamate") increases a(CHEBI:"nitric oxide") |
| pubmed:19419557 | p(MESH:"Receptors, Ionotropic Glutamate") increases bp(GO:"regulation of calcium-mediated signaling") |
| pubmed:19419557 | p(HGNCGENEFAMILY:"Glutamate metabotropic receptors") association a(CHEBI:"glutamate(2-)") |
| pubmed:30837838 | p(HGNCGENEFAMILY:"Glutamate metabotropic receptors") increases act(p(MESH:"Sodium Channels")) |
| pubmed:30837838 | p(HGNCGENEFAMILY:"Glutamate metabotropic receptors") increases act(p(MESH:"Calcium Channels")) |
| pubmed:19126755 | p(HGNCGENEFAMILY:"Glutamate ionotropic receptor kainate type subunits") association a(CHEBI:anandamide) |
| pubmed:19419557 | act(p(FPLX:GRIA)) increases a(CHEBI:"nitric oxide") |
| pubmed:19419557 | act(p(FPLX:GRIA)) increases bp(GO:"negative regulation of calcium-mediated signaling") |
| pubmed:19419557 | a(CONSO:"amyloid-beta oligomers") increases act(p(HGNC:GRIN1)) |
| pubmed:21871088 | a(CONSO:"amyloid-beta oligomers") decreases bp(GO:"long-term synaptic potentiation") |
| pubmed:21871088 | a(CONSO:"amyloid-beta oligomers") increases bp(GO:"long-term synaptic depression") |
| pubmed:21871088 | a(CONSO:"amyloid-beta oligomers") decreases bp(GO:"synaptic signaling") |
| pubmed:21871088 | a(CONSO:"amyloid-beta oligomers") increases path(MESH:"Cognitive Dysfunction") |
| pubmed:19293145 | a(CONSO:"amyloid-beta oligomers") positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pubmed:19126755 | a(CONSO:"amyloid-beta oligomers") regulates act(p(HGNC:CHRNA7)) |
| pubmed:19293145 | a(CONSO:"amyloid-beta oligomers") isA a(CHEBI:amyloid-beta) |
| pubmed:19293145 | a(CONSO:"amyloid-beta oligomers") association path(CONSO:neurotoxicity) |
| pubmed:19293145 | a(CONSO:"amyloid-beta oligomers") directlyIncreases path(CONSO:neurotoxicity) |
| pubmed:19293145 | a(CONSO:"amyloid-beta oligomers") increases act(p(FPLX:JNK)) |
| pubmed:19293145 | a(CONSO:"amyloid-beta oligomers") decreases act(p(FPLX:ERK)) |
| pubmed:26813123 | a(CONSO:"amyloid-beta oligomers") association act(a(GO:"cholinergic synapse")) |
| pubmed:30145931 | a(CONSO:"amyloid-beta oligomers") increases p(HGNC:MAPT, loc(MESH:Dendrites)) |
| pubmed:24760868 | a(CONSO:"amyloid-beta oligomers") increases p(HGNC:MAPT, loc(MESH:"Post-Synaptic Density")) |
| pubmed:24760868 | a(CONSO:"amyloid-beta oligomers") decreases p(HGNC:MAPT, loc(GO:synapse)) |
| pubmed:24760868 | a(CONSO:"amyloid-beta oligomers") decreases p(HGNC:MAPT, loc(GO:synapse)) |
| pubmed:24760868 | a(CONSO:"amyloid-beta oligomers") increases p(HGNC:MAPT, loc(GO:synapse)) |
| pubmed:23528736 | a(CONSO:"amyloid-beta oligomers") increases p(HGNC:MAPT) |
| pubmed:30145931 | a(CONSO:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) |
| pubmed:30145931 | a(CONSO:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:17403556 | a(CONSO:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:17403556 | a(CONSO:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:24760868 | a(CONSO:"amyloid-beta oligomers") increases p(HGNC:DLG4) |
| pubmed:24760868 | a(CONSO:"amyloid-beta oligomers") decreases p(HGNC:DLG4, loc(GO:synapse)) |
| pubmed:24760868 | a(CONSO:"amyloid-beta oligomers") increases p(HGNC:GRIA1) |
| pubmed:24760868 | a(CONSO:"amyloid-beta oligomers") increases p(HGNC:FYN) |
| pubmed:24760868 | a(CONSO:"amyloid-beta oligomers") decreases bp(GO:"actin filament polymerization") |
| pubmed:24760868 | a(CONSO:"amyloid-beta oligomers") decreases a(MESH:Actins, loc(GO:synapse)) |
| pubmed:24760868 | a(CONSO:"amyloid-beta oligomers") increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pubmed:24760868 | a(CONSO:"amyloid-beta oligomers") increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pubmed:24760868 | a(CONSO:"amyloid-beta oligomers") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:24760868 | a(CONSO:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:24760868 | a(CONSO:"amyloid-beta oligomers") regulates p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24760868 | a(CONSO:"amyloid-beta oligomers") causesNoChange p(HGNC:MAPT, var("p.Ser404Ala"), loc(MESH:"Dendritic Spines")) |
| pubmed:23528736 | a(CONSO:"amyloid-beta oligomers") decreases act(p(FPLX:Proteasome)) |
| pubmed:22156579 | act(a(CONSO:"amyloid-beta oligomers")) positiveCorrelation a(MESH:"Microtubule-Associated Proteins") |
| pubmed:19419557 | complex(a(CONSO:"amyloid-beta oligomers"), p(HGNC:GRIN1)) association act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pubmed:20556492 | p(HGNC:GRIN2B) increases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pubmed:20556492 | p(HGNC:GRIN2B) increases path(MP:0008235) |
| pubmed:19419557 | bp(GO:"calcium-mediated signaling") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19419557 | bp(GO:"calcium-mediated signaling") association a(CHEBI:amyloid-beta) |
| pubmed:19293145 | bp(GO:"calcium-mediated signaling") association act(a(CHEBI:amyloid-beta)) |
| pubmed:19293145 | bp(GO:"calcium-mediated signaling") association bp(MESH:Neuroprotection) |
| pubmed:19293145 | bp(GO:"calcium-mediated signaling") association act(p(HGNC:CHRNA7)) |
| pubmed:19293145 | bp(GO:"calcium-mediated signaling") association a(CHEBI:nicotine) |
| pubmed:19293145 | bp(GO:"calcium-mediated signaling") association composite(p(HGNC:JAK2), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:23746257 | bp(GO:"calcium-mediated signaling") association p(FPLX:HSP90) |
| pubmed:19419557 | composite(p(HGNC:CAMK2A), p(HGNC:CAMK2B)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29428175 | p(HGNC:CAMK2B) positiveCorrelation bp(MESH:"Calcium Signaling") |
| pubmed:29428175 | p(HGNC:CAMK2B) association bp(MESH:"Calcium Signaling") |
| pubmed:29428175 | p(HGNC:CAMK2B) regulates p(MESH:"Ion Channels") |
| pubmed:29428175 | p(HGNC:CAMK2B) regulates p(MESH:"Cytoskeletal Proteins") |
| pubmed:29428175 | p(HGNC:CAMK2B) regulates p(HGNC:CHRNA7) |
| pubmed:29428175 | act(p(HGNC:CAMK2B)) increases bp(GO:"actin rod assembly") |
| pubmed:29428175 | act(p(HGNC:CAMK2B)) increases a(MESH:Axons) |
| pubmed:12428809 | p(HGNC:CAMK2B) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21722302 | p(HGNC:CAMK2B) increases act(p(HGNC:PRKAA1)) |
| pubmed:21722302 | p(HGNC:CAMK2B) increases act(complex(GO:"Atg1/ULK1 kinase complex")) |
| pubmed:27796283 | p(HGNC:CAMK2B) increases p(CONSO:"Kalirin 7", pmod(go:0006468 ! "protein phosphorylation", Thr, 95)) |
| pubmed:19419557 | p(FPLX:CAPN) increases act(p(HGNC:CDK5), ma(go:0016301 ! "kinase activity")) |
| pubmed:19419557 | act(p(FPLX:CAPN), ma(go:0008233 ! "peptidase activity")) increases rxn(reactants(p(HGNC:CDK5R1)), products(p(CONSO:"CDK5R1 p25"))) |
| pubmed:24653673 | p(FPLX:CAPN) increases p(HGNC:IGBP1, frag("?")) |
| pubmed:22908190 | p(FPLX:CAPN) increases deg(p(HGNC:MAPT)) |
| pubmed:29626319 | p(FPLX:CAPN) increases deg(p(HGNC:MAPT)) |
| pubmed:29626319 | p(FPLX:CAPN) increases p(HGNC:MAPT, frag("?")) |
| pubmed:26118667 | act(p(FPLX:CAPN)) positiveCorrelation rxn(reactants(p(RGD:Cdk5r1)), products(p(CONSO:"CDK5R1 p25"))) |
| pubmed:26118667 | act(p(FPLX:CAPN)) increases deg(p(HGNC:NFKBIA)) |
| pubmed:26118667 | act(p(FPLX:CAPN)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19419557 | p(CONSO:"CDK5R1 p25") regulates act(p(HGNC:CDK5), ma(go:0016301 ! "kinase activity")) |
| pubmed:26118667 | p(CONSO:"CDK5R1 p25") negativeCorrelation p(HGNC:CDK5R1) |
| pubmed:26118667 | p(CONSO:"CDK5R1 p25") equivalentTo p(HGNC:CDK5R1, frag("99_307")) |
| pubmed:26118667 | p(CONSO:"CDK5R1 p25") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26118667 | p(CONSO:"CDK5R1 p25") positiveCorrelation a(GO:"neurofibrillary tangle") |
| pubmed:26118667 | p(CONSO:"CDK5R1 p25") regulates p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27087442 | p(CONSO:"CDK5R1 p25") positiveCorrelation p(CONSO:"Tau epitope, AT8") |
| pubmed:14642273 | p(CONSO:"CDK5R1 p25") directlyIncreases act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) |
| pubmed:19419557 | complex(p(HGNC:ITPR1), p(HGNC:PSEN1)) increases bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") |
| pubmed:20556492 | act(p(HGNC:ITPR1)) increases a(CHEBI:"1D-myo-inositol 1,4,5-trisphosphate") |
| pubmed:19419557 | bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") association complex(p(HGNC:ATP2A3), p(HGNC:PSEN1)) |
| pubmed:19419557 | bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") increases p(HGNC:APP, frag("672_713")) |
| pubmed:29428175 | bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") increases bp(MESH:"Calcium Signaling") |
| pubmed:29428175 | bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") association a(MESH:Phospholipids) |
| pubmed:29428175 | bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") increases act(p(HGNC:CAMK2B, loc(MESH:Synapses))) |
| pubmed:29428175 | bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") regulates bp(GO:"calcium ion homeostasis") |
| pubmed:19419557 | complex(p(HGNC:PSEN1), p(HGNC:RYR1), p(HGNC:RYR2), p(HGNC:RYR3)) increases bp(GO:"regulation of ryanodine-sensitive calcium-release channel activity") |
| pubmed:19419557 | bp(GO:"regulation of ryanodine-sensitive calcium-release channel activity") increases p(HGNC:APP, frag("672_713")) |
| pubmed:19419557 | complex(p(HGNC:ATP2A3), p(HGNC:PSEN1)) association bp(GO:"sequestering of calcium ion") |
| pubmed:19419557 | complex(p(HGNC:ATP2A3), p(HGNC:PSEN1)) association bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") |
| pubmed:19419557 | bp(GO:"sequestering of calcium ion") association complex(p(HGNC:ATP2A3), p(HGNC:PSEN1)) |
| pubmed:26968346 | bp(GO:"sequestering of calcium ion") positiveCorrelation p(HGNC:PSEN1) |
| pubmed:26968346 | bp(GO:"sequestering of calcium ion") positiveCorrelation p(HGNC:PSEN2) |
| pubmed:19419557 | p(HGNC:CALHM1) association bp(GO:"calcium ion import") |
| pubmed:19419557 | p(HGNC:CALHM1) increases act(p(FPLX:ERK)) |
| pubmed:25999473 | p(HGNC:CALHM1) increases tloc(p(HGNC:IDE), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:18585350 | p(HGNC:CALHM1) increases path(MESH:"Alzheimer Disease") |
| pubmed:19419557 | p(HGNC:CALHM1, var("p.Pro86Leu")) association path(MESH:"Alzheimer Disease") |
| pubmed:19419557 | p(HGNC:CALHM1, var("p.Pro86Leu")) increases a(CHEBI:amyloid-beta) |
| pubmed:19419557 | g(DBSNP:rs2986017) increases p(HGNC:CALHM1, var("p.Pro86Leu")) |
| pubmed:19419557 | g(DBSNP:rs2986017) increases a(CHEBI:amyloid-beta) |
| pubmed:18585350 | g(DBSNP:rs2986017) increases bp(GO:"neuron death") |
| pubmed:18585350 | g(DBSNP:rs2986017) increases a(NIFT:"Hippocampal atrophy") |
| pubmed:18585350 | g(DBSNP:rs2986017) increases p(HGNC:APP) |
| pubmed:18585350 | g(DBSNP:rs2986017) increases bp(GO:"calcium ion homeostasis") |
| pubmed:21657833 | a(CHEBI:decursinol) association p(HGNC:ABCB4) |
| pubmed:21657833 | a(CHEBI:decursinol) association p(HGNC:ABCC2) |
| pubmed:21657833 | p(HGNC:ABCB4) association a(CHEBI:decursinol) |
| pubmed:21657833 | p(HGNC:ABCC2) association a(CHEBI:decursinol) |
| pubmed:23556446 | p(HGNC:ABCC2) association p(HGNC:ABCC2, var("p.Cys3972Thr")) |
| pubmed:23556446 | p(HGNC:ABCC2) association path(MESH:"Alzheimer Disease") |
| pubmed:23556446 | p(HGNCGENEFAMILY:"ATP binding cassette subfamily A") association path(MESH:"Alzheimer Disease") |
| pubmed:23556446 | g(DBSNP:rs3740066) association path(MESH:"Alzheimer Disease") |
| pubmed:23556446 | p(HGNC:ABCC2, var("p.Cys3972Thr")) association p(HGNC:ABCC2) |
| pubmed:23556446 | p(HGNC:ABCC2, var("p.Cys3972Thr")) association path(MESH:"Alzheimer Disease") |
| pubmed:23556446 | p(HGNC:ABCB1) increases a(CHEBI:amyloid-beta) |
| pubmed:26195256 | p(HGNC:ABCB1) increases tloc(a(CHEBI:amyloid-beta)) |
| pubmed:26195256 | p(HGNC:ABCB1) increases tloc(a(CHEBI:amyloid-beta)) |
| pubmed:26195256 | p(HGNC:ABCB1) increases tloc(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | p(HGNC:ABCB1) increases tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:Brain), toLoc(GO:"extracellular region")) |
| pubmed:29626319 | p(HGNC:ABCB1) decreases a(CHEBI:amyloid-beta) |
| pubmed:26195256 | p(HGNC:ABCB1) increases act(p(HGNC:APOE)) |
| pubmed:26195256 | p(HGNC:ABCB1) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24173717 | g(DBSNP:rs9807444) increases p(HGNC:TUBB6) |
| pubmed:24173717 | p(HGNC:TUBB6) negativeCorrelation bp(GO:"microtubule cytoskeleton organization") |
| pubmed:24173717 | p(HGNC:TUBB6) negativeCorrelation bp(GO:pyroptosis) |
| pubmed:24393168 | p(HGNC:TUBB6) association a(CHEBI:crocin-1) |
| pubmed:26973255 | p(HGNC:TUBB6) biomarkerFor path(MESH:"Alzheimer Disease") |
| pubmed:24275654 | p(HGNC:TUBB6) association p(HGNC:LRRK2) |
| pubmed:24173717 | a(CHEBI:paclitaxel) decreases p(HGNC:TUBB6) |
| pubmed:29758300 | a(CHEBI:paclitaxel) increases a(GO:microtubule) |
| pubmed:30116051 | a(CHEBI:paclitaxel) increases a(GO:microtubule) |
| pubmed:29758300 | a(CHEBI:paclitaxel) increases tloc(a(GO:autophagosome), fromLoc(GO:"extracellular space"), toLoc(MESH:Neurons)) |
| pubmed:22941973 | a(CHEBI:paclitaxel) decreases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:22941973 | a(CHEBI:paclitaxel) increases p(RGD:Syp) |
| pubmed:24393168 | a(CHEBI:crocin-1) association p(HGNC:TUBB6) |
| pubmed:26330360 | g(HGNC:TUBB6) association path(MESH:"Colonic Neoplasms") |
| pubmed:26330360 | path(MESH:"Colonic Neoplasms") association g(HGNC:TUBB6) |
| pubmed:24275654 | p(HGNC:TUBB4A) association p(HGNC:LRRK2) |
| pubmed:25024322 | a(NIFT:"Free and Cued Selective Reminding Test") positiveCorrelation p(HGNC:CHI3L1) |
| pubmed:25024322 | a(CONSO:"Mini-Mental Status Exam") positiveCorrelation p(HGNC:CHI3L1) |
| pubmed:25865441 | a(NIFT:"Cortical Thickness") negativeCorrelation p(HGNC:CHI3L1) |
| pubmed:25865441 | a(NIFT:"Cortical Thickness") negativeCorrelation p(HGNC:CHI3L1) |
| pubmed:26836182 | a(NIFT:"Cortical Thickness") negativeCorrelation p(HGNC:CHI3L1) |
| pubmed:26027813 | a(NIFT:"Cortical Thickness") association a(CHEBI:amyloid-beta) |
| pubmed:21504134 | a(NIFT:"Cortical Thickness") negativeCorrelation p(HGNC:APOE) |
| pubmed:22711244 | a(NIFT:"Cortical Thickness") positiveCorrelation p(HGNC:ARHGEF40) |
| pubmed:25862420 | g(DBSNP:rs10524523) association a(NIFT:"Cortical Thinning") |
| pubmed:23183136 | g(DBSNP:rs10524523) association p(HGNC:PSEN1, pmod(go:0006479 ! "protein methylation", Leu, 146)) |
| pubmed:25862420 | a(NIFT:"Cortical Thinning") association g(DBSNP:rs10524523) |
| pubmed:24080518 | a(NIFT:"Cortical Thinning") association p(HGNC:APOE) |
| pubmed:26027813 | a(NIFT:"Cortical Thinning") increases path(MESH:"Alzheimer Disease") |
| pubmed:21504134 | a(NIFT:"Cortical Thinning") positiveCorrelation a(NIFT:"Mini mental state exam") |
| pubmed:24479631 | p(HGNC:BCHE) increases a(NIFT:"Cortical Thinning") |
| pubmed:24479631 | p(HGNC:BCHE) increases a(NIFT:"Cortical Thinning") |
| pubmed:19940480 | p(HGNC:BCHE) increases a(NIFT:"Cortical Thinning") |
| pubmed:19293145 | p(HGNC:BCHE) decreases a(CHEBI:acetylcholine) |
| pubmed:18986241 | act(p(HGNC:BCHE), ma(go:0003824 ! "catalytic activity")) directlyIncreases deg(a(CHEBI:acetylcholine)) |
| pubmed:18986241 | p(HGNC:BCHE) association a(MESH:"Neurofibrillary Tangles") |
| pubmed:18986241 | p(HGNC:BCHE) association path(MESH:"Plaque, Amyloid") |
| pubmed:18986241 | p(HGNC:BCHE) association path(MESH:Cognition) |
| pubmed:25570489 | p(HGNC:TF) increases a(NIFT:"Cerebral atrophy") |
| pubmed:25570489 | p(HGNC:TF) association a(NIFT:"Cerebral atrophy") |
| pubmed:25570489 | a(NIFT:"Cerebral atrophy") association p(HGNC:TF) |
| pubmed:25570489 | a(NIFT:"Cerebral atrophy") association p(HGNC:APP) |
| pubmed:3484831 | a(NIFT:"Cerebral atrophy") positiveCorrelation p(HGNC:ACHE) |
| pubmed:3484831 | a(NIFT:"Cerebral atrophy") positiveCorrelation p(HGNC:ACHE) |
| pubmed:25570489 | a(NIFT:"Ventricular expansion") association p(HGNC:ESR1) |
| pubmed:25570489 | a(NIFT:"Ventricular expansion") association p(HGNC:SORCS1) |
| pubmed:25027412 | p(HGNC:TREM2, var("p.Arg47His")) increases a(NIFT:"Temporal lobe atrophy") |
| pubmed:25027412 | p(HGNC:TREM2, var("p.Arg47His")) increases a(NIFT:"Temporal lobe atrophy") |
| pubmed:25027412 | p(HGNC:TREM2, var("p.Arg47His")) increases a(NIFT:"Grey matter volume") |
| pubmed:31413141 | p(HGNC:TREM2, var("p.Arg47His")) causesNoChange p(HGNC:TREM2, frag("?")) |
| pubmed:29626319 | p(HGNC:TREM2, var("p.Arg47His")) decreases act(a(MESH:Microglia)) |
| pubmed:29626319 | p(HGNC:TREM2, var("p.Arg47His")) increases a(CHEBI:amyloid-beta) |
| pubmed:25027412 | g(DBSNP:rs75932628) increases a(NIFT:"Temporal lobe atrophy") |
| pubmed:23533697 | a(NIFT:"Cerebral blood flow") increases a(NIFT:"Glucose hypometabolism") |
| pubmed:16151770 | a(NIFT:"Cerebral blood flow") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23300102 | a(NIFT:"Cerebral blood flow") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23533697 | a(NIFT:"Glucose hypometabolism") increases a(NIFT:"Temporal lobe atrophy") |
| pubmed:20100581 | a(NIFT:"Grey matter volume") association path(MESH:"Alzheimer Disease") |
| pubmed:21547229 | a(NIFT:"Grey matter volume") positiveCorrelation g(DBSNP:rs10932886) |
| pubmed:26996954 | a(NIFT:"Grey matter volume") association p(HGNC:SORL1) |
| pubmed:26996954 | a(NIFT:"Grey matter volume") negativeCorrelation g(DBSNP:rs3824968) |
| pubmed:25999473 | p(HGNC:IDE) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:21718217 | p(HGNC:IDE) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:30116051 | p(HGNC:IDE) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:26195256 | p(HGNC:IDE) increases deg(a(CHEBI:amyloid-beta, loc(GO:intracellular))) |
| pubmed:26195256 | p(HGNC:IDE) increases deg(a(CHEBI:amyloid-beta, loc(GO:"extracellular region"))) |
| pubmed:26195256 | p(HGNC:IDE) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:26195256 | p(HGNC:IDE) decreases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | p(HGNC:IDE) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | p(HGNC:IDE) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | p(HGNC:IDE) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:28019679 | p(HGNC:IDE) decreases a(CHEBI:amyloid-beta) |
| pubmed:30116051 | p(HGNC:IDE) increases deg(p(HGNC:IAPP)) |
| pubmed:30116051 | p(HGNC:IDE) decreases a(CONSO:"alpha-synuclein aggregates") |
| pubmed:30116051 | p(HGNC:IDE) decreases a(CONSO:"amyloid-beta aggregates") |
| pubmed:30116051 | p(HGNC:IDE) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:30116051 | p(HGNC:IDE) increases bp(GO:macroautophagy) |
| pubmed:30116051 | p(HGNC:IDE) decreases a(CONSO:"alpha-synuclein fibrils") |
| pubmed:30116051 | p(HGNC:IDE) increases deg(a(CONSO:"alpha-synuclein fibrils")) |
| pubmed:26195256 | p(HGNC:IDE) increases deg(p(HGNC:INS)) |
| pubmed:29626319 | p(HGNC:IDE) negativeCorrelation bp(GO:aging) |
| pubmed:29626319 | p(HGNC:IDE) negativeCorrelation path(MESH:"Diabetes Mellitus") |
| pubmed:28019679 | p(HGNC:IDE) regulates complex(GO:"NLRP3 inflammasome complex") |
| pubmed:20100581 | g(DBSNP:rs6463843) association p(HGNC:NXPH1) |
| pubmed:20100581 | g(DBSNP:rs6463843) decreases a(NIFT:"Grey matter volume") |
| pubmed:20100581 | g(DBSNP:rs6463843) increases a(NIFT:"Grey matter atrophy") |
| pubmed:20100581 | p(HGNC:NXPH1) association g(DBSNP:rs6463843) |
| pubmed:20100581 | p(HGNC:NXPH1) association path(MESH:"Alzheimer Disease") |
| pubmed:20100581 | p(HGNC:NXPH1) increases a(NIFT:"Grey matter atrophy") |
| pubmed:20100581 | p(HGNC:NOS1) association p(HGNC:IFNG) |
| pubmed:19293145 | act(p(HGNC:NOS1)) increases a(CHEBI:"nitric oxide") |
| pubmed:20100581 | bp(HP:Neurodegeneration) association p(HGNC:APP) |
| pubmed:24563850 | bp(HP:Neurodegeneration) association bp(GO:"protein oxidation") |
| pubmed:30126037 | bp(HP:Neurodegeneration) association p(HGNC:CDKN2A) |
| pubmed:28420982 | bp(HP:Neurodegeneration) decreases tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:10936883 | p(HGNC:LPL) increases bp(GO:"lipid transport") |
| pubmed:10936883 | p(HGNC:LPL) increases complex(p(HGNC:APOE), p(HGNC:LRP1B)) |
| pubmed:10936883 | p(HGNC:LPL) increases path(MESH:"Alzheimer Disease") |
| pubmed:10936883 | p(HGNC:LPL) increases a(MESH:Hippocampus) |
| pubmed:10936883 | p(HGNC:LPL, var("p.447Ter")) decreases complex(GO:"neurofibrillary tangle") |
| pubmed:10936883 | p(HGNC:LPL, var("p.447Ter")) increases a(NIFT:"Cortical Thickness") |
| pubmed:10936883 | a(MESH:Hippocampus) increases path(MESH:Dementia) |
| pubmed:19126755 | a(MESH:Hippocampus) increases p(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:19126755 | a(MESH:Hippocampus) increases p(HGNC:CHRNA7) |
| pubmed:19721446 | a(MESH:Hippocampus) association p(HGNC:CHRNA7) |
| pubmed:24511233 | a(MESH:Hippocampus) association bp(GO:cognition) |
| pubmed:24511233 | a(MESH:Hippocampus) association bp(GO:learning) |
| pubmed:24511233 | a(MESH:Hippocampus) association bp(GO:learning) |
| pubmed:24511233 | a(MESH:Hippocampus) association bp(GO:memory) |
| pubmed:24511233 | a(MESH:Hippocampus) association bp(GO:memory) |
| pubmed:19721446 | a(MESH:Hippocampus) association bp(GO:memory) |
| pubmed:24511233 | a(MESH:Hippocampus) association p(HGNC:CHRM4) |
| pubmed:24590577 | a(MESH:Hippocampus) association p(HGNC:CHRM1) |
| pubmed:24590577 | a(MESH:Hippocampus) association p(HGNC:CHRM2) |
| pubmed:24590577 | a(MESH:Hippocampus) association p(HGNC:CHRM3) |
| pubmed:10936883 | complex(p(HGNC:APOE), p(HGNC:LPL), p(HGNCGENEFAMILY:"Low density lipoprotein receptors")) increases path(MESH:"Plaque, Amyloid") |
| pubmed:16340157 | a(NIFT:"Grey matter atrophy") positiveCorrelation path(MESH:Depression) |
| pubmed:16340157 | a(NIFT:"Grey matter atrophy") negativeCorrelation a(MESH:Neurons) |
| pubmed:16340157 | a(NIFT:"Grey matter atrophy") decreases bp(GO:neurogenesis) |
| pubmed:26996954 | a(NIFT:"Grey matter atrophy") positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:19592509 | p(HGNC:EPHA4) increases a(NIFT:"Grey matter volume") |
| pubmed:21547229 | p(HGNC:EPHA4) increases g(DBSNP:rs10932886) |
| pubmed:21547229 | g(DBSNP:rs10932886) positiveCorrelation a(NIFT:"Grey matter volume") |
| pubmed:21547229 | g(DBSNP:rs10932886) increases a(NIFT:"Grey matter atrophy") |
| pubmed:3122646 | a(NIFT:"White matter") association p(HGNC:MAPT) |
| pubmed:19940480 | a(NIFT:"Brain volume") positiveCorrelation p(HGNC:APOE, var("p.Cys130Arg")) |
| pubmed:26996954 | a(NIFT:"Brain volume") association g(DBSNP:rs3824968) |
| pubmed:19940480 | a(NIFT:"Ventricular volume") negativeCorrelation p(HGNC:APOE, var("p.Cys130Arg")) |
| pubmed:22711244 | p(HGNC:ARHGEF40) positiveCorrelation a(NIFT:"Cortical Thickness") |
| pubmed:22711244 | p(HGNC:ARHGEF40) association g(DBSNP:rs3748348) |
| pubmed:22711244 | g(DBSNP:rs3748348) association p(HGNC:ARHGEF40) |
| pubmed:10449594 | a(NIFT:Hypoperfusion) positiveCorrelation a(NIFT:"Mini mental state exam") |
| pubmed:16340157 | p(HGNC:HSPA5) increases bp(GO:neurogenesis) |
| pubmed:22040696 | p(HGNC:HSPA5) increases p(FPLX:CHRN) |
| pubmed:21722302 | p(HGNC:HSPA5) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21722302 | p(HGNC:HSPA5) biomarkerFor bp(MESH:"Endoplasmic Reticulum Stress") |
| pubmed:30740335 | p(HGNC:HSPA5) association path(MESH:"Unfolded Protein Response") |
| pubmed:30740335 | p(HGNC:HSPA5) increases path(MESH:"Unfolded Protein Response") |
| pubmed:21673407 | p(HGNC:HTR4) association bp(GO:memory) |
| pubmed:21673407 | p(HGNC:HTR4) association bp(GO:learning) |
| pubmed:21673407 | p(HGNC:HTR4) association tloc(a(CHEBI:acetylcholine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21673407 | p(HGNC:HTR4) decreases p(HGNC:APP, frag("672_713")) |
| pubmed:21673407 | complex(a(NIFT:"Pittsburgh Compound B"), p(HGNC:HTR4)) positiveCorrelation p(HGNC:APP, frag("672_713")) |
| pubmed:23183136 | p(HGNC:PSEN1, pmod(go:0006479 ! "protein methylation", Leu, 146)) association g(DBSNP:rs10524523) |
| pubmed:23183136 | p(HGNC:PSEN1, pmod(go:0006479 ! "protein methylation", Leu, 146)) decreases a(NIFT:"Cortical Thickness") |
| pubmed:22550605 | p(HGNC:TOMM40, var("?")) association path(MESH:"Alzheimer Disease") |
| pubmed:22550605 | p(HGNC:TOMM40, var("?")) association a(NIFT:"Hippocampus volume") |
| pubmed:22550605 | p(HGNC:TOMM40, var("?")) association a(NIFT:Precuneus) |
| pubmed:22550605 | a(NIFT:Precuneus) association p(HGNC:TOMM40, var("?")) |
| pubmed:26996954 | path(MESH:"Cerebrovascular Disorders") association g(HGNC:SORL1) |
| pubmed:26996954 | path(MESH:"Cerebrovascular Disorders") increases path(MESH:Dementia) |
| pubmed:26996954 | path(MESH:"Cerebrovascular Disorders") association g(DBSNP:rs3824968) |
| pubmed:26996954 | a(NIFT:"White Matter Hyperintensity") association g(DBSNP:rs3824968) |
| pubmed:21871088 | a(NIFT:"White matter lesion") association bp(GO:"microglial cell activation") |
| pubmed:21543606 | bp(GO:"regulation of lipid metabolic process") association a(NIFT:"Fractional anisotropy") |
| pubmed:21543606 | bp(GO:"regulation of lipid metabolic process") association bp(GO:myelination) |
| pubmed:14970312 | bp(GO:"regulation of lipid metabolic process") association bp(MESH:"Oxidative Stress") |
| pubmed:14970312 | bp(GO:"regulation of lipid metabolic process") association p(HGNC:APP, frag("672_713")) |
| pubmed:21543606 | bp(GO:"axonal defasciculation") association bp(GO:"regulation of synaptic plasticity") |
| pubmed:14970312 | bp(GO:"sphingolipid metabolic process") association path(MESH:"Alzheimer Disease") |
| pubmed:14970312 | bp(GO:"sphingolipid metabolic process") increases a(CHEBI:ceramide) |
| pubmed:18986241 | bp(GO:"sphingolipid metabolic process") association act(p(HGNC:NGFR)) |
| pubmed:14970312 | bp(GO:"cholesterol metabolic process") association path(MESH:"Alzheimer Disease") |
| pubmed:14970312 | bp(GO:"cholesterol metabolic process") increases a(CHEBI:cholesterol) |
| pubmed:14970312 | a(CHEBI:ceramide) increases bp(GO:"neuron death") |
| pubmed:24653673 | a(CHEBI:ceramide) increases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:29758300 | a(CHEBI:ceramide) regulates bp(GO:"sphingolipid metabolic process") |
| pubmed:29758300 | a(CHEBI:ceramide) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:14970312 | a(CHEBI:cholesterol) decreases a(CHEBI:acyl-CoA) |
| pubmed:21718217 | a(CHEBI:cholesterol) increases act(p(HGNC:NR1H3)) |
| pubmed:19721446 | a(CHEBI:cholesterol) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:29758300 | a(CHEBI:cholesterol) increases a(MESH:"Amyloid beta-Peptides") |
| pubmed:29758300 | a(CHEBI:cholesterol) regulates act(complex(GO:"gamma-secretase complex")) |
| pubmed:22908190 | a(CHEBI:cholesterol) positiveCorrelation p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") |
| pubmed:22908190 | a(CHEBI:cholesterol) positiveCorrelation bp(GO:endocytosis) |
| pubmed:22908190 | a(CHEBI:cholesterol) increases a(GO:endosome) |
| pubmed:14970312 | bp(GO:"regulation of sphingomyelin catabolic process") decreases a(CHEBI:ceramide) |
| pubmed:14970312 | bp(GO:"regulation of sphingomyelin catabolic process") decreases a(CHEBI:cholesterol) |
| pubmed:14970312 | a(CHEBI:acyl-CoA) decreases bp(GO:"neuron apoptotic process") |
| pubmed:24189376 | p(HGNC:CNR1) causesNoChange p(HGNC:APP, frag("672_713")) |
| pubmed:19126755 | p(HGNC:CNR1) association a(CHEBI:anandamide) |
| pubmed:30061532 | path(MESH:"Lewy Body Disease") association p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:30061532 | path(MESH:"Lewy Body Disease") association a(CHEBI:amyloid-beta) |
| pubmed:17009926 | path(MESH:"Lewy Body Disease") negativeCorrelation act(p(FPLX:CHRN)) |
| pubmed:17009926 | path(MESH:"Lewy Body Disease") negativeCorrelation p(FPLX:CHRN) |
| pubmed:27075649 | path(MESH:"Lewy Body Disease") positiveCorrelation a(CONSO:CONSO00016) |
| pubmed:29980653 | path(MESH:"Lewy Body Disease") isA path(MESH:"Neurodegenerative Diseases") |
| pubmed:30837838 | path(MESH:"Lewy Body Disease") association p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) |
| pubmed:30837838 | path(MESH:"Lewy Body Disease") association p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) |
| pubmed:26091809 | path(MESH:"Lewy Body Disease") increases path(MESH:Mortality) |
| pubmed:24590577 | a(CONSO:"Tau aggregates") increases path(MESH:"Neurofibrillary Tangles") |
| pubmed:24027553 | a(CONSO:"Tau aggregates") increases path(MESH:"Neurofibrillary Tangles") |
| pubmed:28083634 | a(CONSO:"Tau aggregates") negativeCorrelation p(HGNC:OTUB1) |
| pubmed:29758300 | a(CONSO:"Tau aggregates") association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:23528736 | a(CONSO:"Tau aggregates") association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:29758300 | a(CONSO:"Tau aggregates") association bp(GO:autophagy) |
| pubmed:29758300 | a(CONSO:"Tau aggregates") association complex(a(MESH:"Lipid Bilayers"), p(HGNC:MAPT)) |
| pubmed:22908190 | a(CONSO:"Tau aggregates") increases p(CONSO:"Tau aggregates", pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:22908190 | a(CONSO:"Tau aggregates") decreases act(complex(GO:"proteasome complex")) |
| pubmed:30116051 | a(CONSO:"Tau aggregates") decreases act(complex(GO:"proteasome complex")) |
| pubmed:30116051 | a(CONSO:"Tau aggregates") decreases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) |
| pubmed:30116051 | a(CONSO:"Tau aggregates") decreases deg(a(CONSO:"Tau oligomers")) |
| pubmed:30116051 | a(CONSO:"Tau aggregates") decreases bp(GO:"chaperone-mediated autophagy") |
| pubmed:24027553 | a(CONSO:"Tau aggregates") positiveCorrelation path(CONSO:neurotoxicity) |
| pubmed:24027553 | a(CONSO:"Tau aggregates") decreases act(p(HGNCGENEFAMILY:Proteasome)) |
| pubmed:24027553 | a(CONSO:"Tau aggregates") positiveCorrelation a(MESH:Autophagosomes) |
| pubmed:24027553 | a(CONSO:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, frag("561_685")) |
| pubmed:27574109 | a(CONSO:"Tau aggregates") decreases bp(GO:"anterograde axonal transport") |
| pubmed:29590627 | a(CONSO:"Tau aggregates") increases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:29590627 | a(CONSO:"Tau aggregates") increases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) |
| pubmed:29590627 | a(CONSO:"Tau aggregates") increases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:29590627 | a(CONSO:"Tau aggregates") increases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) |
| pubmed:29590627 | a(CONSO:"Tau aggregates") increases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) |
| pubmed:26751493 | tloc(a(CONSO:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) positiveCorrelation a(CONSO:"Tau aggregates") |
| pubmed:26751493 | a(CONSO:"Tau aggregates") positiveCorrelation tloc(a(CONSO:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) |
| pubmed:29590627 | a(CONSO:"Tau aggregates") association a(GO:"early endosome") |
| pubmed:29590627 | a(CONSO:"Tau aggregates") association a(GO:"late endosome") |
| pubmed:29590627 | a(CONSO:"Tau aggregates") association a(GO:lysosome) |
| pubmed:22611162 | a(CONSO:"Tau aggregates") increases path(CONSO:proteotoxicity) |
| pubmed:22611162 | a(CONSO:"Tau aggregates") decreases bp(GO:"axonal transport") |
| pubmed:26631930 | a(CONSO:"Tau aggregates") decreases bp(GO:"axonal transport") |
| pubmed:22611162 | a(CONSO:"Tau aggregates") decreases bp(GO:"synaptic signaling") |
| pubmed:22611162 | a(CONSO:"Tau aggregates") decreases bp(GO:"synaptic signaling") |
| pubmed:22611162 | a(CONSO:"Tau aggregates") decreases bp(GO:"maintenance of synapse structure") |
| pubmed:22611162 | a(CONSO:"Tau aggregates") decreases p(UNIPROT:O02495) |
| pubmed:22611162 | a(CONSO:"Tau aggregates") decreases bp(GO:"intracellular distribution of mitochondria") |
| pubmed:22611162 | a(CONSO:"Tau aggregates") decreases bp(GO:"axonal transport of mitochondrion") |
| pubmed:28528849 | a(CONSO:"Tau aggregates") causesNoChange bp(GO:"cell death") |
| pubmed:26458742 | a(CONSO:"Tau aggregates") causesNoChange bp(GO:"cell death") |
| pubmed:28528849 | a(CONSO:"Tau aggregates") causesNoChange a(GO:membrane) |
| pubmed:29988016 | a(CONSO:"Tau aggregates") negativeCorrelation a(CHEBI:heparin) |
| pubmed:29988016 | a(CONSO:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27373205 | a(CONSO:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26631930 | a(CONSO:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22817713 | a(CONSO:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21882945 | a(CONSO:"Tau aggregates") increases path(MESH:Tauopathies) |
| pubmed:29311797 | a(CONSO:"Tau aggregates") increases path(MESH:Tauopathies) |
| pubmed:30640040 | a(CONSO:"Tau aggregates") increases bp(GO:"cell killing") |
| pubmed:29191965 | a(CONSO:"Tau aggregates") decreases act(a(GO:synapse)) |
| pubmed:29191965 | a(CONSO:"Tau aggregates") decreases a(GO:presynapse) |
| pubmed:29191965 | a(CONSO:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25374103 | a(CONSO:"Tau aggregates") increases a(GO:"neurofibrillary tangle") |
| pubmed:28420982 | a(CONSO:"Tau aggregates") increases a(GO:"neurofibrillary tangle") |
| pubmed:29844403 | a(CONSO:"Tau aggregates") positiveCorrelation a(GO:"neurofibrillary tangle") |
| pubmed:28877763 | a(CONSO:"Tau aggregates") association p(MGI:Syk, pmod(go:0006468 ! "protein phosphorylation", Tyr, 525)) |
| pubmed:28877763 | a(CONSO:"Tau aggregates") association p(MGI:Syk, pmod(go:0006468 ! "protein phosphorylation", Tyr, 526)) |
| pubmed:28877763 | a(CONSO:"Tau aggregates") association p(HGNC:SYK, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28877763 | a(CONSO:"Tau aggregates") positiveCorrelation p(HGNC:SYK, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28420982 | a(CONSO:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:27373205 | a(CONSO:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:22817713 | a(CONSO:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:22817713 | a(CONSO:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:22817713 | a(CONSO:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:28420982 | a(CONSO:"Tau aggregates") association bp(MESH:"Neuronal Plasticity") |
| pubmed:28420982 | a(CONSO:"Tau aggregates") association tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28420982 | a(CONSO:"Tau aggregates") association a(CHEBI:dextran) |
| pubmed:29311797 | a(CONSO:"Tau aggregates") association p(HGNC:HDAC6) |
| pubmed:29311797 | a(CONSO:"Tau aggregates") association bp(GO:"glucocorticoid receptor signaling pathway") |
| pubmed:26458742 | a(CONSO:"Tau aggregates") increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Neurons)) |
| pubmed:27373205 | a(CONSO:"Tau aggregates") causesNoChange bp(GO:"retrograde axonal protein transport") |
| pubmed:26631930 | a(CONSO:"Tau aggregates") negativeCorrelation complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:26631930 | a(CONSO:"Tau aggregates") positiveCorrelation bp(GO:aging) |
| pubmed:26631930 | a(CONSO:"Tau aggregates") decreases bp(GO:"microtubule polymerization") |
| pubmed:26631930 | a(CONSO:"Tau aggregates") decreases act(a(MESH:Neurons)) |
| pubmed:26631930 | a(CONSO:"Tau aggregates") increases path(CONSO:Neurodegeneration) |
| pubmed:22817713 | a(CONSO:"Tau aggregates") increases act(p(HGNC:PPP1CA)) |
| pubmed:22817713 | a(CONSO:"Tau aggregates") increases act(p(HGNC:GSK3A)) |
| pubmed:22817713 | a(CONSO:"Tau aggregates") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:22817713 | a(CONSO:"Tau aggregates") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:23531502 | a(CONSO:"Tau aggregates") association act(p(HGNC:GSK3B)) |
| pubmed:23531502 | a(CONSO:"Tau aggregates") association act(p(HGNC:MAPK14)) |
| pubmed:26400044 | a(CONSO:"Tau aggregates") increases complex(p(CONSO:"Tau aggregates"), p(MGI:Dpysl2, pmod(go:0006468 ! "protein phosphorylation")), p(MGI:Wasf1, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:28877763 | a(CONSO:"Tau aggregates") increases act(p(HGNC:SYK)) |
| pubmed:30061532 | a(CHEBI:"mTOR inhibitor") decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:30061532 | a(CHEBI:"mTOR inhibitor") decreases p(HGNC:SNCA, pmod(CONSO:misfolded)) |
| pubmed:30061532 | a(CHEBI:"mTOR inhibitor") decreases p(HGNC:TARDBP, pmod(CONSO:misfolded)) |
| pubmed:26010758 | path(MESH:"Interpersonal Relations") association a(CHEBI:amyloid-beta) |
| pubmed:30061532 | a(CHEBI:methamphetamine) decreases bp(GO:"dopamine secretion, neurotransmission") |
| pubmed:30061532 | a(CHEBI:methamphetamine) association bp(GO:"dopamine secretion, neurotransmission") |
| pubmed:30061532 | a(CHEBI:methamphetamine) decreases act(p(HGNCGENEFAMILY:"Dopamine receptors")) |
| pubmed:30061532 | a(CHEBI:methamphetamine) decreases act(p(HGNC:DRD1)) |
| pubmed:30061532 | a(CHEBI:methamphetamine) increases p(HGNC:DRD1) |
| pubmed:30061532 | a(CHEBI:methamphetamine) increases bp(GO:"non-canonical Wnt signaling pathway") |
| pubmed:30061532 | a(CHEBI:methamphetamine) increases path(MESH:Hallucinations) |
| pubmed:30061532 | a(CHEBI:methamphetamine) increases path(MESH:Delusions) |
| pubmed:30061532 | a(CHEBI:methamphetamine) decreases act(g(HGNC:DISC1)) |
| pubmed:30061532 | a(CHEBI:methamphetamine) decreases act(g(HGNC:NRG1)) |
| pubmed:30061532 | a(CHEBI:methamphetamine) decreases act(g(HGNC:DPYSL2)) |
| pubmed:30061532 | a(CHEBI:methamphetamine) increases path(MESH:"Psychoses, Substance-Induced") |
| pubmed:30061532 | a(CHEBI:methamphetamine) decreases act(p(HGNC:SLC6A3)) |
| pubmed:30061532 | a(CHEBI:methamphetamine) decreases p(HGNC:SLC6A3) |
| pubmed:30061532 | a(CHEBI:methamphetamine) decreases a(CHEBI:dopamine, loc(MESH:"Nerve Endings")) |
| pubmed:30061532 | a(CHEBI:methamphetamine) decreases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30061532 | a(CHEBI:methamphetamine) increases a(CHEBI:dopamine, loc(GO:cytosol)) |
| pubmed:30061532 | a(CHEBI:methamphetamine) increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30061532 | a(CHEBI:methamphetamine) decreases bp(GO:autophagy) |
| pubmed:30061532 | a(CHEBI:methamphetamine) decreases act(p(HGNC:SLC18A2)) |
| pubmed:30061532 | a(CHEBI:methamphetamine) negativeCorrelation p(HGNC:SLC18A2) |
| pubmed:30061532 | a(CHEBI:methamphetamine) increases bp(GO:"response to oxidative stress") |
| pubmed:30061532 | a(CHEBI:methamphetamine) increases act(p(FPLX:AKT)) |
| pubmed:30061532 | a(CHEBI:methamphetamine) increases act(p(HGNC:MTOR)) |
| pubmed:19293145 | act(a(CHEBI:methamphetamine)) increases path(CONSO:Neurodegeneration) |
| pubmed:30061532 | bp(GO:"dopamine secretion, neurotransmission") association a(CHEBI:methamphetamine) |
| pubmed:30061532 | bp(GO:"dopamine secretion, neurotransmission") association bp(GO:autophagy) |
| pubmed:30061532 | bp(GO:"dopamine secretion, neurotransmission") association p(HGNC:DISC1) |
| pubmed:30061532 | act(p(HGNC:DRD1)) positiveCorrelation path(MESH:Schizophrenia) |
| pubmed:30061532 | act(p(HGNC:DRD1)) increases act(p(HGNC:MTOR)) |
| pubmed:30061532 | act(p(HGNC:DRD1)) increases act(p(HGNC:MTOR)) |
| pubmed:30061532 | act(p(HGNC:DRD1)) decreases bp(GO:autophagy) |
| pubmed:30061532 | act(p(HGNC:DRD1)) increases act(p(FPLX:AKT)) |
| pubmed:30061532 | act(p(HGNC:DRD1)) increases r(HGNC:CDK5) |
| pubmed:30061532 | act(p(HGNC:DRD1)) increases p(HGNC:CDK5) |
| pubmed:30061532 | p(HGNC:DRD1) increases act(p(HGNC:CDK5)) |
| pubmed:26979166 | act(p(HGNC:DRD1)) decreases act(p(HGNC:CHRNA7)) |
| pubmed:26979166 | act(p(HGNC:DRD1)) increases act(p(HGNC:PRKACA)) |
| pubmed:24511233 | path(MESH:Delusions) association path(MESH:Schizophrenia) |
| pubmed:24511233 | path(MESH:Delusions) biomarkerFor path(MESH:Schizophrenia) |
| pubmed:19721446 | path(MESH:Delusions) association path(MESH:Schizophrenia) |
| pubmed:30061532 | g(HGNC:DISC1) association path(MESH:Schizophrenia) |
| pubmed:30061532 | g(HGNC:DISC1) association path(MESH:Schizophrenia) |
| pubmed:30061532 | act(g(HGNC:DISC1)) association act(p(HGNC:MTOR)) |
| pubmed:30061532 | g(HGNC:NRG1) association path(MESH:Schizophrenia) |
| pubmed:30061532 | act(g(HGNC:NRG1)) association act(p(HGNC:MTOR)) |
| pubmed:21482353 | g(HGNC:NRG1) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pubmed:30061532 | g(HGNC:DPYSL2) association path(MESH:Schizophrenia) |
| pubmed:30061532 | g(HGNC:DPYSL2) association path(MESH:Schizophrenia) |
| pubmed:30061532 | act(g(HGNC:DPYSL2)) association act(p(HGNC:MTOR)) |
| pubmed:30061532 | g(HGNC:DPYSL2) increases p(HGNC:DPYSL2) |
| pubmed:30061532 | a(CHEBI:dopamine) positiveCorrelation path(MESH:Schizophrenia) |
| pubmed:30061532 | tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association path(MESH:Schizophrenia) |
| pubmed:30061532 | a(CHEBI:dopamine) regulates bp(GO:autophagy) |
| pubmed:30061532 | a(CHEBI:dopamine) association p(HGNC:SLC18A2) |
| pubmed:30061532 | a(CHEBI:dopamine) increases bp(GO:"response to oxidative stress") |
| pubmed:19126755 | a(CHEBI:dopamine) decreases path(MESH:"Parkinson Disease") |
| pubmed:21787755 | tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association r(HGNC:CHRNA6) |
| pubmed:21787755 | tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association p(HGNC:CHRNA6) |
| pubmed:28391535 | a(CHEBI:dopamine) regulates path(MESH:Pleasure) |
| pubmed:28391535 | a(CHEBI:dopamine) regulates path(MESH:Motivation) |
| pubmed:29687724 | a(CHEBI:dopamine) association path(MESH:Chorea) |
| pubmed:29687724 | a(CHEBI:dopamine) association path(MESH:Dystonia) |
| pubmed:29687724 | a(CHEBI:dopamine) association path(MESH:"Huntington Disease") |
| pubmed:29687724 | a(CHEBI:dopamine) increases bp(GO:cognition) |
| pubmed:29687724 | a(CHEBI:dopamine) increases bp(GO:"motor behavior") |
| pubmed:30027901 | a(CHEBI:dopamine) increases path(CONSO:Neurodegeneration) |
| pubmed:30027901 | a(CHEBI:dopamine) decreases act(p(HGNCGENEFAMILY:"Mitochondrial complex II: succinate dehydrogenase subunits")) |
| pubmed:23393546 | a(CHEBI:dopamine) regulates p(HGNC:PPP1R1B) |
| pubmed:27075649 | a(CHEBI:dopamine) increases a(CONSO:CONSO00093) |
| pubmed:27075649 | a(CHEBI:dopamine) increases a(CONSO:CONSO00093) |
| pubmed:30061532 | a(CHEBI:"lithium(1+)") decreases act(p(HGNC:MTOR)) |
| pubmed:30061532 | a(CHEBI:"lithium(1+)") decreases path(MESH:Schizophrenia) |
| pubmed:30061532 | a(CHEBI:"lithium(1+)") decreases path(MESH:Schizophrenia) |
| pubmed:30061532 | a(CHEBI:"lithium(1+)") decreases path(MESH:"Psychotic Disorders") |
| pubmed:18930136 | a(CHEBI:"lithium(1+)") increases bp(GO:autophagy) |
| pubmed:30116051 | a(CHEBI:"lithium(1+)") increases bp(GO:autophagy) |
| pubmed:29626319 | a(CHEBI:"lithium(1+)") increases bp(GO:autophagy) |
| pubmed:27181519 | a(CHEBI:"lithium(1+)") association bp(GO:autophagy) |
| pubmed:18930136 | a(CHEBI:"lithium(1+)") decreases path(CONSO:Neurodegeneration) |
| pubmed:30116051 | a(CHEBI:"lithium(1+)") decreases act(p(HGNC:IMPA1)) |
| pubmed:30116051 | a(CHEBI:"lithium(1+)") decreases a(PUBCHEM:55310) |
| pubmed:30116051 | a(CHEBI:"lithium(1+)") decreases p(HGNC:SNCA) |
| pubmed:30116051 | a(CHEBI:"lithium(1+)") decreases p(HGNC:SOD1) |
| pubmed:30116051 | a(CHEBI:"lithium(1+)") decreases p(HGNC:HTT) |
| pubmed:30116051 | a(CHEBI:"lithium(1+)") decreases p(HGNC:MAPT) |
| pubmed:30116051 | a(CHEBI:"lithium(1+)") increases bp(GO:"motor behavior") |
| pubmed:30061532 | p(HGNC:SLC18A2) association a(CHEBI:dopamine) |
| pubmed:30061532 | p(HGNC:SLC18A2) negativeCorrelation path(MESH:Schizophrenia) |
| pubmed:30061532 | p(HGNC:SLC18A2) negativeCorrelation a(CHEBI:methamphetamine) |
| pubmed:30061532 | bp(GO:"cytoskeleton organization") negativeCorrelation path(MESH:Schizophrenia) |
| pubmed:30061532 | bp(GO:"cytoskeleton organization") increases bp(GO:"neuron-neuron synaptic transmission") |
| pubmed:30061532 | bp(GO:"cytoskeleton organization") association complex(p(HGNC:CDK5), p(HGNC:DPYSL2)) |
| pubmed:23516100 | bp(GO:"cytoskeleton organization") negativeCorrelation act(p(HGNCGENEFAMILY:Calpains)) |
| pubmed:23516100 | bp(GO:"cytoskeleton organization") negativeCorrelation path(DOID:"Alzheimer's disease") |
| pubmed:23454242 | bp(GO:"cytoskeleton organization") association p(HGNC:PPP2R2A) |
| pubmed:23454242 | bp(GO:"cytoskeleton organization") association p(HGNC:PPP2R2B) |
| pubmed:23454242 | bp(GO:"cytoskeleton organization") association p(HGNC:PPP2R2C) |
| pubmed:29311797 | bp(GO:"cytoskeleton organization") association p(HGNC:HSP90AB1) |
| pubmed:30061532 | complex(a(GO:microtubule), a(MESH:"Microtubule-Associated Proteins")) increases bp(GO:"microtubule polymerization") |
| pubmed:30061532 | act(a(GO:microtubule)) negativeCorrelation path(MESH:Schizophrenia) |
| pubmed:14556719 | a(GO:microtubule) association p(HGNC:MAPT) |
| pubmed:26631930 | a(GO:microtubule) negativeCorrelation tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) |
| pubmed:18930136 | a(GO:microtubule) increases bp(GO:"autophagosome-lysosome fusion") |
| pubmed:8282104 | a(GO:microtubule) association p(HGNC:CDK5) |
| pubmed:8282104 | a(GO:microtubule) association p(HGNC:PRKACA) |
| pubmed:8282104 | a(GO:microtubule) association p(FPLX:ERK) |
| pubmed:8282104 | a(GO:microtubule) association p(FPLX:GSK3) |
| pubmed:16566606 | a(GO:microtubule) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) |
| pubmed:16566606 | a(GO:microtubule) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 29)) |
| pubmed:16566606 | a(GO:microtubule) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 197)) |
| pubmed:16566606 | a(GO:microtubule) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 394)) |
| pubmed:22692785 | a(MESH:"Microtubule-Associated Proteins") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:22156579 | a(MESH:"Microtubule-Associated Proteins") positiveCorrelation act(a(CONSO:"amyloid-beta oligomers")) |
| pubmed:30061532 | bp(GO:"neuron-neuron synaptic transmission") negativeCorrelation path(MESH:Schizophrenia) |
| pubmed:30108137 | bp(GO:"neuron-neuron synaptic transmission") association bp(GO:"ATP export") |
| pubmed:27299292 | bp(GO:"neuron-neuron synaptic transmission") positiveCorrelation p(HGNC:TFEB) |
| pubmed:30061532 | a(GO:dendrite) association p(HGNC:DISC1) |
| pubmed:30061532 | path(MESH:"Frontotemporal Lobar Degeneration") association path(MESH:"Psychotic Disorders") |
| pubmed:30061532 | path(MESH:"Frontotemporal Lobar Degeneration") association path(MESH:Catatonia) |
| pubmed:30061532 | path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:TARDBP, loc(GO:"inclusion body")) |
| pubmed:30061532 | path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:TARDBP, loc(CONSO:"dystrophic neurite")) |
| pubmed:21722302 | path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:TARDBP) |
| pubmed:30837838 | path(MESH:"Frontotemporal Lobar Degeneration") negativeCorrelation act(p(HGNC:TARDBP, loc(GO:nucleus))) |
| pubmed:30837838 | path(MESH:"Frontotemporal Lobar Degeneration") increases p(HGNC:TARDBP, loc(GO:"inclusion body")) |
| pubmed:22908190 | path(MESH:"Frontotemporal Lobar Degeneration") positiveCorrelation p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:30837838 | path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:30837838 | path(MESH:"Frontotemporal Lobar Degeneration") increases p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:26631930 | path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:FUS) |
| pubmed:30837838 | path(MESH:"Frontotemporal Lobar Degeneration") increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30837838 | path(MESH:"Frontotemporal Lobar Degeneration") increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30837838 | path(MESH:"Frontotemporal Lobar Degeneration") increases p(HGNC:TARDBP, frag("1_102")) |
| pubmed:30837838 | path(MESH:"Frontotemporal Lobar Degeneration") increases p(HGNC:TARDBP, var("p.Ala90Val")) |
| pubmed:30837838 | path(MESH:"Frontotemporal Lobar Degeneration") increases p(HGNC:TARDBP, var("p.Asn267Ser")) |
| pubmed:30837838 | path(MESH:"Frontotemporal Lobar Degeneration") increases p(HGNC:TARDBP, var("p.Arg361Thr")) |
| pubmed:30837838 | path(MESH:"Frontotemporal Lobar Degeneration") increases p(HGNC:TARDBP, var("p.Gly295Ser")) |
| pubmed:30837838 | path(MESH:"Frontotemporal Lobar Degeneration") increases p(HGNC:TARDBP, frag("274_414"), pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30837838 | path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:MAP1LC3A, loc(GO:"inclusion body")) |
| pubmed:30837838 | path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:SQSTM1, loc(GO:"inclusion body")) |
| pubmed:30061532 | path(MESH:Catatonia) association path(MESH:"Frontotemporal Lobar Degeneration") |
| pubmed:30061532 | path(MESH:Catatonia) association path(MESH:Schizophrenia) |
| pubmed:30061532 | p(HGNC:DISC1) association path(MESH:Schizophrenia) |
| pubmed:30061532 | p(HGNC:DISC1) association path(MESH:Schizophrenia) |
| pubmed:30061532 | p(HGNC:DISC1) increases a(CONSO:"protein aggregates") |
| pubmed:30061532 | p(HGNC:DISC1) association bp(MESH:Neurogenesis) |
| pubmed:30061532 | p(HGNC:DISC1) association bp(GO:"neuron migration") |
| pubmed:30061532 | p(HGNC:DISC1) association bp(GO:"axon development") |
| pubmed:30061532 | p(HGNC:DISC1) association a(GO:dendrite) |
| pubmed:30061532 | p(HGNC:DISC1) association a(GO:synapse) |
| pubmed:30061532 | p(HGNC:DISC1) association bp(GO:"dopamine secretion, neurotransmission") |
| pubmed:30061532 | p(HGNC:DISC1) decreases act(p(HGNC:CCDC88A)) |
| pubmed:30061532 | a(CONSO:"protein aggregates") increases path(MESH:"Neurodegenerative Diseases") |
| pubmed:29758300 | a(CONSO:"protein aggregates") positiveCorrelation path(MESH:"Neurodegenerative Diseases") |
| pubmed:22020111 | a(CONSO:"protein aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22020111 | a(CONSO:"protein aggregates") positiveCorrelation path(MESH:"Parkinson Disease") |
| pubmed:22020111 | a(CONSO:"protein aggregates") positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:14556719 | a(CONSO:"protein aggregates") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:29980653 | a(CONSO:"protein aggregates", loc(MESH:"Central Nervous System")) increases path(CONSO:Neurodegeneration) |
| pubmed:29980653 | a(CONSO:"protein aggregates") increases path(CONSO:Neurodegeneration) |
| pubmed:27181519 | a(CONSO:"protein aggregates") association complex(p(HGNC:OPTN), p(HGNC:TBK1)) |
| pubmed:30061532 | p(HGNC:DTNBP1) association path(MESH:Schizophrenia) |
| pubmed:30061532 | p(HGNC:DTNBP1) association path(MESH:Schizophrenia) |
| pubmed:30061532 | p(HGNC:DTNBP1) increases a(CONSO:"protein aggregates") |
| pubmed:30061532 | p(HGNC:DTNBP1) association a(GO:"microtubule cytoskeleton") |
| pubmed:30061532 | p(HGNC:DTNBP1) association act(a(GO:cytoskeleton)) |
| pubmed:30061532 | p(HGNC:DTNBP1) association bp(GO:"synaptic vesicle transport") |
| pubmed:30106381 | a(GO:"actin cytoskeleton") association p(HGNC:MTOR) |
| pubmed:30061532 | p(HGNC:DPYSL2) association path(MESH:Schizophrenia) |
| pubmed:30562574 | p(HGNC:DPYSL2) association path(MESH:Schizophrenia) |
| pubmed:30061532 | p(HGNC:DPYSL2) association bp(GO:"axon development") |
| pubmed:30061532 | p(HGNC:DPYSL2) regulates a(GO:"dendritic spine") |
| pubmed:30562574 | p(HGNC:DPYSL2) isA a(MESH:Neuregulins) |
| pubmed:30562574 | p(HGNC:DPYSL2) increases path(MESH:"Neuronal Outgrowth") |
| pubmed:30562574 | p(HGNC:DPYSL2) increases bp(GO:"neuron projection development") |
| pubmed:30562574 | p(HGNC:DPYSL2) association path(DOID:schizophrenia) |
| pubmed:30562574 | p(HGNC:DPYSL2) association path(MESH:"Neurodegenerative Diseases") |
| pubmed:30061532 | a(GO:"microtubule cytoskeleton") association p(HGNC:DTNBP1) |
| pubmed:24653673 | a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(HGNC:GSK3B)) |
| pubmed:24653673 | a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(HGNC:CDK5)) |
| pubmed:24653673 | a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(FPLX:ERK)) |
| pubmed:30061532 | bp(GO:"synaptic vesicle transport") association p(HGNC:DTNBP1) |
| pubmed:14556719 | bp(GO:"synaptic vesicle transport") association p(HGNC:SYT11, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:30061532 | r(HGNC:MAP6) association act(p(HGNC:MTOR)) |
| pubmed:30061532 | p(HGNC:MAP6) association act(p(HGNC:MTOR)) |
| pubmed:30061532 | bp(MESH:Neurogenesis) association p(HGNC:DISC1) |
| pubmed:30061532 | bp(GO:"neuron migration") association p(HGNC:DISC1) |
| pubmed:30061532 | p(HGNC:DISC1, var("?")) increases path(MESH:Schizophrenia) |
| pubmed:30061532 | p(HGNC:DISC1, var("?")) increases path(MESH:Schizophrenia) |
| pubmed:30061532 | p(HGNC:DISC1, var("?")) decreases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30061532 | p(HGNC:DISC1, var("?")) increases act(p(FPLX:AKT)) |
| pubmed:30061532 | p(HGNC:DISC1, var("?")) increases act(p(HGNC:MTOR)) |
| pubmed:30061532 | p(HGNC:DISC1, var("?")) decreases bp(GO:autophagy) |
| pubmed:30061532 | p(HGNC:CCDC88A) increases act(p(FPLX:AKT)) |
| pubmed:30061532 | complex(p(FPLX:AKT), p(HGNC:CCDC88A)) increases act(p(FPLX:AKT)) |
| pubmed:30061532 | complex(p(HGNC:CCDC88A), p(HGNC:DISC1)) decreases act(p(FPLX:AKT)) |
| pubmed:30061532 | complex(p(HGNC:CCDC88A), p(HGNC:DISC1)) decreases act(p(FPLX:AKT)) |
| pubmed:30061532 | complex(p(HGNC:CCDC88A), p(HGNC:DISC1)) decreases act(p(HGNC:MTOR)) |
| pubmed:30061532 | p(MGI:Rictor) decreases bp(GO:"protein kinase B signaling") |
| pubmed:30061532 | p(HGNC:NRG1) association path(MESH:Schizophrenia) |
| pubmed:30061532 | p(HGNC:NRG1) association path(MESH:Schizophrenia) |
| pubmed:30061532 | p(HGNC:NRG1) regulates p(HGNC:DISC1) |
| pubmed:30061532 | p(HGNC:NRG1) association bp(GO:"protein kinase B signaling") |
| pubmed:30061532 | p(HGNC:NRG1) association act(p(HGNC:MTOR)) |
| pubmed:30061532 | complex(p(HGNC:ERBB4), p(HGNC:NRG1)) regulates bp(GO:"generation of neurons") |
| pubmed:30061532 | complex(p(HGNC:ERBB4), p(HGNC:NRG1)) regulates bp(GO:"neuron-neuron synaptic transmission") |
| pubmed:30061532 | act(complex(p(HGNC:ERBB4), p(HGNC:NRG1))) increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30061532 | complex(p(FPLX:PI3K), p(HGNC:ERBB4)) increases act(p(FPLX:PI3K)) |
| pubmed:30061532 | act(p(FPLX:PI3K), ma(go:0016301 ! "kinase activity")) increases p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30061532 | act(p(FPLX:PI3K)) increases act(p(FPLX:AKT)) |
| pubmed:19293145 | p(FPLX:PI3K) increases act(a(CHEBI:nicotine)) |
| pubmed:19293145 | act(p(FPLX:PI3K)) increases act(a(MESH:"Cholinesterase Inhibitors")) |
| pubmed:19293145 | act(p(FPLX:PI3K)) increases p(HGNC:BAX, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19293145 | act(p(FPLX:PI3K)) increases act(p(HGNC:BAD)) |
| pubmed:19293145 | p(FPLX:PI3K) increases act(a(MESH:Synapses)) |
| pubmed:19293145 | act(p(FPLX:PI3K)) decreases bp(GO:"apoptotic process") |
| pubmed:19293145 | p(FPLX:PI3K) regulates act(a(CHEBI:estrogen)) |
| pubmed:22040696 | act(p(FPLX:PI3K)) decreases bp(GO:"neuron death") |
| pubmed:30116051 | act(p(FPLX:PI3K)) increases a(GO:"autophagosome membrane") |
| pubmed:30061532 | a(GO:"dendritic spine") positiveCorrelation p(HGNC:CDK5) |
| pubmed:27807169 | a(GO:"dendritic spine") positiveCorrelation p(RGD:Cdk5r2) |
| pubmed:22156579 | a(GO:"dendritic spine") negativeCorrelation p(HGNC:MARK4) |
| pubmed:30061532 | a(CHEBI:amphetamine) increases r(HGNC:CDK5) |
| pubmed:30061532 | a(CHEBI:amphetamine) increases p(HGNC:CDK5) |
| pubmed:24511233 | act(a(CHEBI:amphetamine)) increases bp(GO:locomotion) |
| pubmed:30061532 | p(HGNC:CDK5R1, frag("?")) increases act(p(HGNC:CDK5)) |
| pubmed:30061532 | complex(p(HGNC:CDK5), p(HGNC:DPYSL2)) association bp(GO:"cytoskeleton organization") |
| pubmed:30061532 | complex(p(HGNC:CDK5), p(HGNC:DPYSL2)) association path(MESH:"Mental Disorders") |
| pubmed:30061532 | path(MESH:"Mental Disorders") association complex(p(HGNC:CDK5), p(HGNC:DPYSL2)) |
| pubmed:30988501 | path(MESH:"Mental Disorders") increases path(MESH:Inflammation) |
| pubmed:30988501 | path(MESH:"Mental Disorders") positiveCorrelation path(MESH:"Psychosocial Deprivation") |
| pubmed:30061532 | p(HGNC:ULK1, var("?")) association path(MESH:Schizophrenia) |
| pubmed:30061532 | p(HGNC:BECN1) association bp(GO:autophagy) |
| pubmed:26968346 | p(HGNC:BECN1) positiveCorrelation bp(GO:autophagy) |
| pubmed:26968346 | act(p(HGNC:BECN1)) positiveCorrelation bp(GO:autophagy) |
| pubmed:18930136 | p(HGNC:BECN1) increases bp(GO:autophagy) |
| pubmed:26702100 | p(HGNC:BECN1) association bp(GO:autophagy) |
| pubmed:26968346 | p(HGNC:BECN1) increases deg(p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) |
| pubmed:29758300 | p(HGNC:BECN1) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | p(HGNC:BECN1) decreases a(MESH:"Amyloid beta-Peptides") |
| pubmed:29758300 | p(HGNC:BECN1) association bp(GO:macroautophagy) |
| pubmed:29758300 | p(HGNC:BECN1) association bp(GO:endocytosis) |
| pubmed:29758300 | p(HGNC:BECN1) increases bp(GO:phagocytosis) |
| pubmed:29758300 | p(HGNC:BECN1) increases tloc(p(HGNC:TREM2), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:30116051 | act(p(HGNC:BECN1)) increases bp(GO:"autophagosome assembly") |
| pubmed:27260836 | p(HGNC:BECN1) positiveCorrelation p(HGNC:PICALM) |
| pubmed:30061532 | p(HGNC:ULK2) association bp(GO:autophagy) |
| pubmed:30027901 | p(HGNC:ULK2) increases bp(GO:autophagy) |
| pubmed:30027901 | p(HGNC:ULK2) increases a(MESH:Autophagosomes) |
| pubmed:30061532 | p(HGNC:ATG3) association bp(GO:autophagy) |
| pubmed:30061532 | p(HGNC:ADNP) increases bp(GO:"brain development") |
| pubmed:30106381 | p(HGNC:ADNP) association bp(GO:autophagy) |
| pubmed:30106381 | p(HGNC:ADNP) association bp(GO:autophagy) |
| pubmed:30106381 | p(HGNC:ADNP) association bp(GO:"cell adhesion") |
| pubmed:30106381 | p(HGNC:ADNP) association bp(GO:"immune response") |
| pubmed:30106381 | p(HGNC:ADNP) association path(MESH:"Autistic Disorder") |
| pubmed:30106381 | p(HGNC:ADNP) association act(a(GO:synapse)) |
| pubmed:30106381 | p(HGNC:ADNP) association bp(GO:"nervous system development") |
| pubmed:30106381 | p(HGNC:ADNP) association bp(GO:"synapse assembly") |
| pubmed:30106381 | p(HGNC:ADNP) positiveCorrelation bp(GO:"synaptic transmission, glutamatergic") |
| pubmed:30106381 | p(HGNC:ADNP) regulates bp(GO:"synapse organization") |
| pubmed:30106381 | p(HGNC:ADNP) regulates bp(GO:"cell communication") |
| pubmed:30106381 | p(HGNC:ADNP) association bp(GO:"AMPA glutamate receptor clustering") |
| pubmed:30106381 | p(HGNC:ADNP) association bp(GO:learning) |
| pubmed:30106381 | p(HGNC:ADNP) association bp(GO:memory) |
| pubmed:30664622 | p(HGNC:ADNP) increases bp(GO:memory) |
| pubmed:30106381 | p(HGNC:ADNP) association bp(GO:"social behavior") |
| pubmed:30106381 | p(HGNC:ADNP) regulates bp(GO:"ion transport") |
| pubmed:30106381 | p(HGNC:ADNP) association bp(GO:"vocalization behavior") |
| pubmed:30106381 | p(HGNC:ADNP) regulates g(HGNC:APOE) |
| pubmed:30106381 | p(HGNC:ADNP) association g(HGNC:IQCJ-SCHIP1) |
| pubmed:30106381 | p(HGNC:ADNP) association p(HGNC:NLGN2) |
| pubmed:30106381 | p(HGNC:ADNP) regulates p(HGNC:PAX6) |
| pubmed:30106381 | p(HGNC:ADNP) association p(HGNC:WFS1) |
| pubmed:30106381 | p(HGNC:ADNP) association path(MESH:Inflammation) |
| pubmed:30106381 | p(HGNC:ADNP) association path(MESH:Intelligence) |
| pubmed:30106381 | p(HGNC:ADNP) regulates p(HGNC:MTOR) |
| pubmed:30664622 | p(HGNC:ADNP) decreases path(MESH:"Motor Skills Disorders") |
| pubmed:30664622 | p(HGNC:ADNP) increases a(MESH:"Nerve Fibers, Myelinated") |
| pubmed:30664622 | act(p(HGNC:ADNP)) association a(GO:"glutamatergic synapse") |
| pubmed:30664622 | p(HGNC:ADNP) increases a(GO:"dendritic spine") |
| pubmed:30664622 | act(p(HGNC:ADNP)) association p(HGNC:DLG4) |
| pubmed:29724491 | p(HGNC:ADNP) decreases path(MESH:"Intellectual Disability") |
| pubmed:29724491 | p(HGNC:ADNP) decreases path(MESH:"Developmental Disabilities") |
| pubmed:29724491 | p(HGNC:ADNP) decreases bp(GO:"motor behavior") |
| pubmed:30688256 | bp(GO:"autophagosome assembly") increases bp(GO:mitophagy) |
| pubmed:27299292 | bp(GO:"autophagosome assembly") negativeCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30061532 | a(PUBCHEM:9832404) increases r(HGNC:BECN1) |
| pubmed:30061532 | a(PUBCHEM:9832404) increases r(HGNC:ADNP) |
| pubmed:30061532 | a(PUBCHEM:9832404) increases complex(p(HGNC:ADNP), p(HGNC:MAP1LC3A)) |
| pubmed:30061532 | a(PUBCHEM:9832404) decreases bp(GO:"neuron death") |
| pubmed:30061532 | a(PUBCHEM:9832404) increases bp(GO:cognition) |
| pubmed:30061532 | a(PUBCHEM:9832404) decreases path(MESH:"Mental Disorders") |
| pubmed:30106381 | a(PUBCHEM:9832404) increases a(GO:"dendritic spine") |
| pubmed:30106381 | a(PUBCHEM:9832404) increases a(GO:"dendritic spine") |
| pubmed:30106381 | a(PUBCHEM:9832404) increases a(GO:"dendritic spine") |
| pubmed:30664622 | a(PUBCHEM:9832404) increases a(GO:"dendritic spine") |
| pubmed:30106381 | a(PUBCHEM:9832404) decreases p(HGNC:DLG4) |
| pubmed:30106381 | a(PUBCHEM:9832404) decreases p(HGNC:DLG4) |
| pubmed:30106381 | a(PUBCHEM:9832404) causesNoChange p(HGNC:DLG4) |
| pubmed:30106381 | a(PUBCHEM:9832404) increases p(HGNC:DLG4) |
| pubmed:30664622 | act(a(PUBCHEM:9832404)) association p(HGNC:DLG4) |
| pubmed:30106381 | a(PUBCHEM:9832404) decreases a(GO:"dendritic shaft") |
| pubmed:30106381 | a(PUBCHEM:9832404) decreases a(GO:"dendritic shaft") |
| pubmed:30106381 | a(PUBCHEM:9832404) increases a(GO:"excitatory synapse") |
| pubmed:30106381 | a(PUBCHEM:9832404) association bp(GO:autophagy) |
| pubmed:30106381 | a(PUBCHEM:9832404) association bp(GO:"cell adhesion") |
| pubmed:30106381 | a(PUBCHEM:9832404) association bp(GO:"immune response") |
| pubmed:30106381 | a(PUBCHEM:9832404) association path(MESH:"Autistic Disorder") |
| pubmed:30106381 | a(PUBCHEM:9832404) decreases path(MESH:"Autistic Disorder") |
| pubmed:30106381 | a(PUBCHEM:9832404) association act(a(GO:synapse)) |
| pubmed:30106381 | a(PUBCHEM:9832404) regulates complex(p(HGNC:ADNP), p(HGNC:AKT1)) |
| pubmed:30106381 | a(PUBCHEM:9832404) regulates complex(p(HGNC:ADNP), p(HGNC:DLG4)) |
| pubmed:30106381 | a(PUBCHEM:9832404) increases p(HGNC:FPR3) |
| pubmed:30106381 | a(PUBCHEM:9832404) decreases p(HGNC:TUBB1) |
| pubmed:30106381 | a(PUBCHEM:9832404) association p(HGNC:APOE) |
| pubmed:30106381 | a(PUBCHEM:9832404) association g(HGNC:IQCJ-SCHIP1) |
| pubmed:30106381 | a(PUBCHEM:9832404) association g(HGNC:LIPA) |
| pubmed:30106381 | a(PUBCHEM:9832404) association p(HGNC:NLGN2) |
| pubmed:30106381 | a(PUBCHEM:9832404) association p(HGNC:PAX6) |
| pubmed:30106381 | a(PUBCHEM:9832404) regulates p(HGNC:WFS1) |
| pubmed:30106381 | a(PUBCHEM:9832404) increases p(HGNC:HIST1H3B) |
| pubmed:30106381 | a(PUBCHEM:9832404) decreases p(HGNC:ABCF3) |
| pubmed:30106381 | a(PUBCHEM:9832404) decreases p(HGNC:BMP4) |
| pubmed:30106381 | a(PUBCHEM:9832404) decreases p(HGNC:CDH17) |
| pubmed:30106381 | a(PUBCHEM:9832404) decreases p(HGNC:KDM5D) |
| pubmed:30106381 | a(PUBCHEM:9832404) decreases p(HGNC:KLF1) |
| pubmed:30106381 | a(PUBCHEM:9832404) decreases p(HGNC:PER1) |
| pubmed:30106381 | a(PUBCHEM:9832404) decreases p(HGNC:AKT1) |
| pubmed:30106381 | a(PUBCHEM:9832404) decreases p(HGNC:AIF1) |
| pubmed:30106381 | a(PUBCHEM:9832404) regulates p(HGNC:MTOR) |
| pubmed:30106381 | a(PUBCHEM:9832404) increases path(MESH:"Psychomotor Performance") |
| pubmed:30106381 | a(PUBCHEM:9832404) increases path(MESH:"Psychomotor Performance") |
| pubmed:30106381 | a(PUBCHEM:9832404) decreases path(MESH:"Vestibular Diseases") |
| pubmed:30106381 | a(PUBCHEM:9832404) increases path(MESH:"Motor Activity") |
| pubmed:30106381 | a(PUBCHEM:9832404) increases bp(MESH:"Hand Strength") |
| pubmed:30106381 | a(PUBCHEM:9832404) increases path(MESH:"Recognition (Psychology)") |
| pubmed:30106381 | a(PUBCHEM:9832404) increases path(MESH:Smell) |
| pubmed:30106381 | a(PUBCHEM:9832404) increases bp(GO:"social behavior") |
| pubmed:30664622 | a(PUBCHEM:9832404) increases bp(GO:"social behavior") |
| pubmed:30664622 | a(PUBCHEM:9832404) increases bp(GO:"social behavior") |
| pubmed:30664622 | a(PUBCHEM:9832404) causesNoChange bp(GO:behavior) |
| pubmed:30664622 | a(PUBCHEM:9832404) decreases path(MESH:"Motor Skills Disorders") |
| pubmed:30664622 | a(PUBCHEM:9832404) decreases path(CONSO:Excitotoxicity) |
| pubmed:30664622 | act(a(PUBCHEM:9832404)) association a(GO:"glutamatergic synapse") |
| pubmed:30664622 | a(PUBCHEM:9832404) causesNoChange p(HGNC:SLC17A7) |
| pubmed:30664622 | a(PUBCHEM:9832404) causesNoChange p(HGNC:SLC17A7) |
| pubmed:30664622 | a(PUBCHEM:9832404) increases p(HGNC:SLC17A7) |
| pubmed:30664622 | a(PUBCHEM:9832404) increases r(HGNC:SLC17A7) |
| pubmed:30664622 | a(PUBCHEM:9832404) decreases r(HGNC:SLC17A7) |
| pubmed:30008470 | a(PUBCHEM:9832404) decreases p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) |
| pubmed:30008470 | a(PUBCHEM:9832404) increases complex(a(GO:microtubule), p(HGNC:ADNP)) |
| pubmed:30008470 | a(PUBCHEM:9832404) increases act(p(HGNC:ADNP)) |
| pubmed:30061532 | a(MESH:"Antipsychotic Agents") decreases path(MESH:Schizophrenia) |
| pubmed:30061532 | a(MESH:"Antipsychotic Agents") decreases path(MESH:"Psychotic Disorders") |
| pubmed:24590577 | a(MESH:"Antipsychotic Agents") association a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") |
| pubmed:30061532 | a(PUBCHEM:3396) increases bp(GO:autophagy) |
| pubmed:30061532 | a(CHEBI:trifluoperazine) increases bp(GO:autophagy) |
| pubmed:30061532 | a(CHEBI:pimozide) increases bp(GO:autophagy) |
| pubmed:30061532 | a(CHEBI:pimozide) increases bp(GO:autophagy) |
| pubmed:30061532 | a(CHEBI:pimozide) increases act(p(HGNC:PRKAA1)) |
| pubmed:30061532 | a(CHEBI:pimozide) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30027901 | a(CHEBI:pimozide) decreases path(HP:Hyperkinesis) |
| pubmed:30027901 | a(CHEBI:pimozide) causesNoChange path(MESH:"Motor Disorders") |
| pubmed:30061532 | act(p(HGNC:PRKAA1)) increases p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21722302 | p(HGNC:PRKAA1) negativeCorrelation p(HGNC:MTOR) |
| pubmed:21722302 | p(HGNC:PRKAA1) decreases p(HGNC:MTOR) |
| pubmed:21722302 | p(HGNC:PRKAA1) regulates p(HGNCGENEFAMILY:"TSC complex") |
| pubmed:29758300 | p(HGNC:PRKAA1) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:30061532 | a(CHEBI:chlorpromazine) increases bp(GO:autophagy) |
| pubmed:30061532 | a(CHEBI:chlorpromazine) decreases bp(GO:"protein kinase B signaling") |
| pubmed:30061532 | a(CHEBI:chlorpromazine) decreases act(p(HGNC:MTOR)) |
| pubmed:23038257 | a(CHEBI:chlorpromazine) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) |
| pubmed:23038257 | a(CHEBI:chlorpromazine) association p(HGNC:SCNN1D) |
| pubmed:30027901 | a(CHEBI:chlorpromazine) decreases path(MESH:"Huntington Disease") |
| pubmed:30061532 | a(CHEBI:sertindole) increases bp(GO:autophagy) |
| pubmed:30061532 | a(CHEBI:clozapine) increases bp(GO:autophagy) |
| pubmed:30061532 | a(CHEBI:clozapine) increases bp(GO:autophagy) |
| pubmed:30061532 | a(CHEBI:clozapine) increases p(HGNC:PRKAA1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30061532 | a(CHEBI:clozapine) increases p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30061532 | a(CHEBI:clozapine) increases p(HGNC:BECN1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30061532 | a(CHEBI:clozapine) increases a(GO:autophagosome) |
| pubmed:30061532 | a(CHEBI:clozapine) decreases a(CHEBI:amyloid-beta) |
| pubmed:19721446 | a(CHEBI:clozapine) increases bp(MESH:"Sensory Gating") |
| pubmed:19721446 | a(CHEBI:clozapine) association p(HGNC:CHRNA7) |
| pubmed:30116051 | p(HGNC:BECN1, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(HGNC:BECN1)) |
| pubmed:30027901 | a(GO:autophagosome) decreases deg(a(MESH:"Protein Aggregates")) |
| pubmed:21722302 | a(GO:autophagosome) association path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | a(GO:autophagosome) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:18930136 | a(GO:autophagosome) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:18930136 | a(GO:autophagosome) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | a(GO:autophagosome) association a(CONSO:"dystrophic neurite") |
| pubmed:22908190 | a(GO:autophagosome) increases a(GO:organelle) |
| pubmed:22908190 | a(GO:autophagosome) association p(HGNC:APP) |
| pubmed:18930136 | a(GO:autophagosome) increases bp(GO:autophagy) |
| pubmed:18930136 | a(GO:autophagosome) increases bp(GO:"autophagosome-lysosome fusion") |
| pubmed:18930136 | a(GO:autophagosome) increases complex(a(GO:"multivesicular body"), a(GO:autophagosome), a(GO:endosome)) |
| pubmed:18930136 | a(GO:autophagosome) association complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) |
| pubmed:18930136 | a(GO:autophagosome) positiveCorrelation path(MESH:"Parkinson Disease") |
| pubmed:18930136 | a(GO:autophagosome) positiveCorrelation path(MESH:"Creutzfeldt-Jakob Syndrome") |
| pubmed:18930136 | a(GO:autophagosome) negativeCorrelation p(HGNC:CTSD) |
| pubmed:18930136 | a(GO:autophagosome) positiveCorrelation p(HGNC:DCTN1, var("?")) |
| pubmed:24027553 | p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")) increases path(CONSO:Neurodegeneration) |
| pubmed:30126037 | p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")) causesNoChange p(MGI:Cdkn2a) |
| pubmed:28173111 | p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation r(MGI:Dnm1l) |
| pubmed:30061532 | a(CHEBI:haloperidol) decreases a(CONSO:"huntingtin aggregates") |
| pubmed:30027901 | a(CHEBI:haloperidol) decreases path(MESH:"Huntington Disease") |
| pubmed:30027901 | a(CHEBI:haloperidol) causesNoChange path(MESH:Chorea) |
| pubmed:30027901 | a(CHEBI:haloperidol) decreases path(MESH:Chorea) |
| pubmed:30027901 | a(CHEBI:haloperidol) increases path(MESH:Depression) |
| pubmed:30027901 | a(CHEBI:haloperidol) decreases path(HP:Hyperkinesis) |
| pubmed:30027901 | a(CHEBI:haloperidol) causesNoChange path(MESH:"Motor Disorders") |
| pubmed:30027901 | a(CHEBI:haloperidol) causesNoChange bp(GO:"walking behavior") |
| pubmed:30027901 | a(CHEBI:haloperidol) increases path(HP:Parkinsonism) |
| pubmed:30027901 | a(CHEBI:haloperidol) increases path(HP:"Tardive dyskinesia") |
| pubmed:30027901 | a(CHEBI:haloperidol) increases path(HP:Dysphasia) |
| pubmed:30027901 | a(CONSO:"huntingtin aggregates") regulates bp(MESH:"Cell Survival") |
| pubmed:30027901 | a(CONSO:"huntingtin aggregates") regulates bp(GO:"cell death") |
| pubmed:30027901 | a(CONSO:"huntingtin aggregates") decreases bp(GO:"necrotic cell death") |
| pubmed:30027901 | a(CONSO:"huntingtin aggregates") increases bp(GO:autophagy) |
| pubmed:30027901 | a(CONSO:"huntingtin aggregates") increases path(CONSO:neurotoxicity) |
| pubmed:30027901 | a(CONSO:"huntingtin aggregates") increases path(CONSO:neurotoxicity) |
| pubmed:30027901 | a(CONSO:"huntingtin aggregates") increases p(HGNC:HTT, pmod(CONSO:"CAG repeats")) |
| pubmed:30027901 | a(CONSO:"huntingtin aggregates") decreases composite(a(MESH:Autophagosomes), a(MESH:Lysosomes)) |
| pubmed:24706768 | a(CONSO:"huntingtin aggregates") decreases bp(GO:"clathrin-dependent endocytosis") |
| pubmed:24706768 | a(CONSO:"huntingtin aggregates") decreases bp(GO:"clathrin-dependent endocytosis") |
| pubmed:30515821 | p(HGNC:DNM1L) regulates bp(GO:"mitochondrial fission") |
| pubmed:30515821 | act(p(HGNC:DNM1L), ma(GO:"GTPase activity")) increases bp(GO:"mitochondrial fission") |
| pubmed:30515821 | act(p(HGNC:DNM1L)) increases bp(GO:"energy homeostasis") |
| pubmed:30515821 | act(p(HGNC:DNM1L)) decreases a(CHEBI:"reactive oxygen species") |
| pubmed:30515821 | act(p(HGNC:DNM1L)) increases a(CHEBI:"reactive oxygen species") |
| pubmed:30515821 | act(p(HGNC:DNM1L)) decreases path(DOID:"neurodegenerative disease") |
| pubmed:30515821 | act(p(HGNC:DNM1L)) negativeCorrelation bp(GO:"ATP biosynthetic process") |
| pubmed:30515821 | act(p(HGNC:DNM1L), ma(GO:"GTPase activity")) negativeCorrelation bp(GO:"axonal transport") |
| pubmed:30515821 | act(p(HGNC:DNM1L), ma(GO:"GTPase activity")) decreases a(NCIT:C13281) |
| pubmed:30515821 | act(p(HGNC:DNM1L), ma(GO:"GTPase activity")) increases bp(GO:"neuron death") |
| pubmed:30515821 | act(p(HGNC:DNM1L)) negativeCorrelation bp(MESH:"Energy Metabolism") |
| pubmed:30515821 | act(p(HGNC:DNM1L)) increases bp(NCIT:C17741) |
| pubmed:30688256 | p(HGNC:DNM1L) increases bp(GO:"brain development") |
| pubmed:30688256 | p(HGNC:DNM1L) increases bp(GO:"synapse assembly") |
| pubmed:30515821 | bp(GO:"mitochondrial fission") increases bp(GO:"programmed cell death") |
| pubmed:30515821 | bp(GO:"mitochondrial fission") increases bp(GO:"programmed cell death") |
| pubmed:30515821 | bp(GO:"mitochondrial fission") increases bp(GO:"programmed cell death") |
| pubmed:30515821 | bp(GO:"mitochondrial fission") increases p(HGNC:CASP3, frag("?")) |
| pubmed:30515821 | bp(GO:"mitochondrial fission") increases bp(GO:"neuron differentiation") |
| pubmed:30515821 | bp(GO:"mitochondrial fission") regulates bp(GO:neurogenesis) |
| pubmed:30515821 | bp(GO:"mitochondrial fission") increases path(MESH:"Neuronal Plasticity") |
| pubmed:30515821 | bp(GO:"mitochondrial fission") negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | bp(GO:"mitochondrial fission") increases path(MESH:Inflammation) |
| pubmed:30688256 | bp(GO:"mitochondrial fission") increases act(a(MESH:Neurons)) |
| pubmed:30688256 | bp(GO:"mitochondrial fission") decreases a(MESH:Neurons) |
| pubmed:30688256 | bp(GO:"mitochondrial fission") decreases bp(GO:mitophagy) |
| pubmed:28173111 | bp(GO:"mitochondrial fission") association p(MGI:Fis1) |
| pubmed:28173111 | bp(GO:"mitochondrial fission") association p(MGI:Dnm1l) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") regulates bp(GO:"ATP biosynthetic process") |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") regulates bp(GO:"calcium ion homeostasis") |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") regulates bp(GO:"iron ion homeostasis") |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") regulates bp(GO:"lipid metabolic process") |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") regulates bp(GO:"cellular amino acid metabolic process") |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") regulates bp(MESH:"Body Temperature Regulation") |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") regulates bp(GO:"reactive oxygen species biosynthetic process") |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") regulates bp(GO:aging) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") regulates bp(GO:"programmed cell death") |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") regulates bp(GO:"cell population proliferation") |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") regulates bp(GO:"cell differentiation") |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation path(DOID:"neurodegenerative disease") |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation path(DOID:"breast cancer") |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation path(DOID:"nasopharynx carcinoma") |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") positiveCorrelation bp(GO:"axonal transport") |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") positiveCorrelation bp(GO:"neurotransmitter secretion") |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") positiveCorrelation bp(GO:"neurotransmitter reuptake") |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation path(DOID:"Alzheimer's disease") |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation path(DOID:"Parkinson's disease") |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation composite(p(HGNC:MFN1, var("?")), p(HGNC:MFN2, var("?"))) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation complex(a(CHEBI:amyloid-beta), p(HGNC:DNM1L)) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation complex(p(HGNC:DNM1L), p(HGNC:PRKN, var("?"))) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation complex(p(HGNC:DNM1L), p(HGNC:HTT, var("?"))) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation complex(p(HGNC:DNM1L), p(HGNC:SOD1, var("?"))) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation bp(GO:"mitochondrial fission") |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") positiveCorrelation p(HGNC:PRKN) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation p(HGNC:DNM1) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation p(HGNC:DNM1) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation p(HGNC:DNM1, pmod(go:0017014 ! "protein nitrosylation", Cys, 644)) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation a(CHEBI:"reactive oxygen species") |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation bp(GO:"negative regulation of mitophagy") |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") positiveCorrelation act(a(GO:synapse)) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation path(MESH:"Wounds and Injuries") |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") increases bp(GO:memory) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") increases bp(GO:cognition) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") positiveCorrelation p(HGNC:PINK1) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation p(HGNC:PINK1, var("p.Try437?")) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation p(HGNC:PINK1, var("p.Lys219Met")) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation complex(p(HGNC:DNM1L), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") positiveCorrelation complex(p(HGNC:DNM1L, var("p.Lys38Ala")), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") positiveCorrelation p(HGNC:DNM1L, var("p.Cys644Ala")) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") association p(HGNC:MAPK1) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") positiveCorrelation a(CHEBI:U0126) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") positiveCorrelation p(HGNC:DNM1L, var("p.Ser616Ala")) |
| pubmed:30515821 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:21861815 | path(MESH:"Mitochondrial Dynamics") negativeCorrelation p(HGNC:HTT, pmod(CONSO:"CAG repeats")) |
| pubmed:27190210 | bp(GO:"cell differentiation") association p(HGNC:CHRNA7) |
| pubmed:28901280 | bp(GO:"cell differentiation") association p(MESH:"Receptors, Nicotinic") |
| pubmed:30515821 | path(DOID:"breast cancer") negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | path(DOID:"nasopharynx carcinoma") negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | bp(GO:"neurotransmitter secretion") positiveCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:28445721 | bp(GO:"neurotransmitter secretion") regulates p(FPLX:CHRN) |
| pubmed:18986241 | bp(GO:"neurotransmitter secretion") association p(HGNCGENEFAMILY:Synaptotagmins) |
| pubmed:18986241 | bp(GO:"neurotransmitter secretion") association p(HGNC:NGF) |
| pubmed:21787755 | bp(GO:"neurotransmitter secretion") association p(CONSO:"alpha-7-containing nAChR") |
| pubmed:30515821 | bp(GO:"neurotransmitter reuptake") positiveCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | p(HGNC:MFN1, loc(GO:"mitochondrial outer membrane")) regulates bp(GO:"mitochondrial fusion") |
| pubmed:30688256 | p(HGNC:MFN1) increases bp(GO:"mitochondrial fusion") |
| pubmed:30688256 | bp(GO:"mitochondrial fusion") decreases bp(GO:mitophagy) |
| pubmed:28173111 | bp(GO:"mitochondrial fusion") association p(MGI:Mfn1) |
| pubmed:28173111 | bp(GO:"mitochondrial fusion") association p(MGI:Mfn2) |
| pubmed:28173111 | bp(GO:"mitochondrial fusion") association p(MGI:Opa1) |
| pubmed:30515821 | p(HGNC:MFN2, loc(GO:"mitochondrial outer membrane")) regulates bp(GO:"mitochondrial fusion") |
| pubmed:30688256 | p(HGNC:MFN2) increases bp(GO:"mitochondrial fusion") |
| pubmed:30837838 | p(HGNC:MFN2) increases path(MESH:"Mitochondrial Size") |
| pubmed:30837838 | p(HGNC:MFN2) increases path(MESH:Movement) |
| pubmed:30515821 | p(HGNC:OPA1, loc(GO:"mitochondrial inner membrane")) regulates bp(GO:"mitochondrial fusion") |
| pubmed:30515821 | p(HGNC:OPA1) regulates bp(GO:"mitochondrial inner membrane fusion") |
| pubmed:30515821 | p(HGNC:OPA1) regulates bp(GO:"mitochondrial genome maintenance") |
| pubmed:30515821 | p(HGNC:OPA1) regulates bp(GO:"cristae formation") |
| pubmed:30515821 | composite(p(HGNC:MFN1), p(HGNC:MFN2)) regulates bp(GO:"mitochondrial outer membrane fusion") |
| pubmed:30515821 | composite(p(HGNC:MFN1, var("?")), p(HGNC:MFN2, var("?"))) negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | composite(p(HGNC:MFN1, var("?")), p(HGNC:MFN2, var("?"))) negativeCorrelation bp(GO:"embryo development") |
| pubmed:30515821 | bp(GO:"embryo development") negativeCorrelation composite(p(HGNC:MFN1, var("?")), p(HGNC:MFN2, var("?"))) |
| pubmed:29311797 | bp(GO:"embryo development") association p(HGNC:HSP90AB1) |
| pubmed:30515821 | p(HGNC:OPA1, var("?")) increases path(DOID:"optic atrophy") |
| pubmed:30515821 | p(HGNC:MIEF2, loc(GO:"mitochondrial outer membrane")) increases tloc(p(HGNC:DNM1L), fromLoc(GO:cytosol), toLoc(GO:"mitochondrial outer membrane")) |
| pubmed:30515821 | act(p(HGNC:MIEF2)) increases bp(GO:"energy homeostasis") |
| pubmed:30515821 | act(p(HGNC:MIEF2)) decreases a(CHEBI:"reactive oxygen species") |
| pubmed:30515821 | act(p(HGNC:MIEF2)) decreases path(DOID:"neurodegenerative disease") |
| pubmed:30515821 | p(HGNC:MIEF1, loc(GO:"mitochondrial outer membrane")) increases tloc(p(HGNC:DNM1L), fromLoc(GO:cytosol), toLoc(GO:"mitochondrial outer membrane")) |
| pubmed:30515821 | act(p(HGNC:MIEF1)) increases bp(GO:"energy homeostasis") |
| pubmed:30515821 | act(p(HGNC:MIEF1)) decreases a(CHEBI:"reactive oxygen species") |
| pubmed:30515821 | act(p(HGNC:MIEF1)) decreases path(DOID:"neurodegenerative disease") |
| pubmed:30515821 | p(HGNC:MFF, loc(GO:"mitochondrial outer membrane")) increases tloc(p(HGNC:DNM1L), fromLoc(GO:cytosol), toLoc(GO:"mitochondrial outer membrane")) |
| pubmed:30515821 | act(p(HGNC:MFF)) increases bp(GO:"energy homeostasis") |
| pubmed:30515821 | act(p(HGNC:MFF)) decreases a(CHEBI:"reactive oxygen species") |
| pubmed:30515821 | act(p(HGNC:MFF)) decreases path(DOID:"neurodegenerative disease") |
| pubmed:30515821 | p(HGNC:FIS1, loc(GO:"mitochondrial outer membrane")) increases tloc(p(HGNC:DNM1L), fromLoc(GO:cytosol), toLoc(GO:"mitochondrial outer membrane")) |
| pubmed:30515821 | act(p(HGNC:FIS1)) increases bp(GO:"energy homeostasis") |
| pubmed:30515821 | act(p(HGNC:FIS1)) decreases a(CHEBI:"reactive oxygen species") |
| pubmed:30515821 | act(p(HGNC:FIS1)) decreases path(DOID:"neurodegenerative disease") |
| pubmed:30515821 | complex(p(HGNC:DNM1L), p(HGNC:MIEF2), loc(GO:"mitochondrial outer membrane")) increases bp(GO:"mitochondrial fission") |
| pubmed:30515821 | complex(p(HGNC:DNM1L), p(HGNC:MIEF1), loc(GO:"mitochondrial outer membrane")) increases bp(GO:"mitochondrial fission") |
| pubmed:30515821 | complex(p(HGNC:DNM1L), p(HGNC:FIS1), loc(GO:"mitochondrial outer membrane")) increases bp(GO:"mitochondrial fission") |
| pubmed:30515821 | complex(p(HGNC:DNM1L), p(HGNC:FIS1)) increases bp(GO:"mitochondrial fission") |
| pubmed:30515821 | complex(p(HGNC:DNM1L), p(HGNC:FIS1)) increases r(HGNC:AKAP1) |
| pubmed:30515821 | complex(a(CHEBI:amyloid-beta), p(HGNC:DNM1L)) negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | complex(p(HGNC:DNM1L), p(HGNC:PRKN, var("?"))) negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | p(HGNC:PRKN, var("?")) directlyIncreases bp(GO:"mitochondrial fission") |
| pubmed:30688256 | p(HGNC:PRKN, var("?")) increases path(MESH:"Parkinson Disease") |
| pubmed:30116051 | p(HGNC:PRKN, var("?")) association path(MESH:"Parkinson Disease") |
| pubmed:30688256 | p(HGNC:PRKN, var("?")) decreases bp(GO:mitophagy) |
| pubmed:30116051 | p(HGNC:PRKN, var("?")) decreases bp(GO:mitophagy) |
| pubmed:30688256 | p(HGNC:PRKN, var("?")) increases path(HBP:"mitochondrial dysfunction") |
| pubmed:30688256 | p(HGNC:PRKN, var("?")) increases path(MESH:"Neurodegenerative Diseases") |
| pubmed:28803412 | p(HGNC:PRKN, var("?")) increases path(MESH:"Neurodegenerative Diseases") |
| pubmed:21722302 | p(HGNC:PRKN, var("?")) increases bp(GO:"negative regulation of ubiquitin protein ligase activity") |
| pubmed:21722302 | p(HGNC:PRKN, var("?")) increases bp(MESH:"Cell Death") |
| pubmed:21722302 | p(HGNC:PRKN, var("?")) decreases bp(GO:"parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization") |
| pubmed:14556719 | p(HGNC:PRKN, var("?")) increases path(MESH:"Parkinsonian Disorders") |
| pubmed:14556719 | p(HGNC:PRKN, var("?")) decreases act(p(HGNC:PRKN)) |
| pubmed:14556719 | p(HGNC:PRKN, var("?")) increases p(HGNC:PRKN) |
| pubmed:14556719 | p(HGNC:PRKN, var("?")) decreases act(p(HGNC:SEPT5)) |
| pubmed:14556719 | p(HGNC:PRKN, var("?")) causesNoChange deg(p(HGNC:SNCA)) |
| pubmed:30116051 | p(HGNC:PRKN, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:30515821 | complex(p(HGNC:DNM1L), p(HGNC:HTT, var("?"))) negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | complex(p(HGNC:DNM1L), p(HGNC:SOD1, var("?"))) negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 40), pmod(go:0006468 ! "protein phosphorylation", Ser, 44)) increases act(p(HGNC:DNM1L), ma(GO:"GTPase activity")) |
| pubmed:30515821 | bp(GO:"response to amyloid-beta") increases path(MESH:"Neurotoxicity Syndromes") |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 579)) increases bp(GO:"mitochondrial fission") |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 579)) increases p(HGNC:CASP3, frag("?")) |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 579)) increases bp(GO:"programmed cell death") |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 579)) regulates path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | p(HGNC:CASP3, frag("?")) increases bp(GO:"programmed cell death") |
| pubmed:30515821 | a(CHEBI:seliciclib) decreases p(HGNC:CDK5) |
| pubmed:30515821 | a(CHEBI:seliciclib) decreases p(HGNC:CASP3, frag("?")) |
| pubmed:30515821 | a(CHEBI:seliciclib) decreases bp(GO:"programmed cell death") |
| pubmed:30515821 | a(CHEBI:seliciclib) decreases path(MESH:"Wounds and Injuries") |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 585)) increases act(p(HGNC:DNM1L)) |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 585)) regulates path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | bp(GO:"regulation of NMDA receptor activity") positiveCorrelation a(CHEBI:"reactive oxygen species") |
| pubmed:30515821 | bp(GO:"regulation of NMDA receptor activity") increases path(MESH:"Wounds and Injuries") |
| pubmed:30515821 | p(HGNC:NES) increases bp(GO:"central nervous system development") |
| pubmed:30515821 | p(HGNC:NES) regulates bp(GO:neurogenesis) |
| pubmed:30515821 | p(HGNC:NES) decreases act(p(HGNC:CDK5, loc(GO:cytosol))) |
| pubmed:30515821 | p(HGNC:NES) increases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 592)) |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 592)) increases bp(GO:"mitochondrial fission") |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 592)) increases bp(MESH:Glycolysis) |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 592)) increases bp(GO:"neuron differentiation") |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 592)) regulates bp(GO:neurogenesis) |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 592)) regulates path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) association path(MESH:"Wounds and Injuries") |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) increases path(MESH:"Neuronal Plasticity") |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) regulates path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) increases path(DOID:"Huntington's disease") |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) directlyIncreases act(p(HGNC:DNM1L)) |
| pubmed:30515821 | a(PUBCHEM:4124851) decreases p(HGNC:GSK3B) |
| pubmed:30515821 | a(PUBCHEM:4124851) decreases path(MESH:"Neuronal Plasticity") |
| pubmed:30515821 | a(PUBCHEM:4124851) regulates path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | a(CHEBI:U0126) decreases p(HGNC:MAP2K1) |
| pubmed:23393546 | a(CHEBI:U0126) decreases p(HGNC:MAP2K1) |
| pubmed:30515821 | a(CHEBI:U0126) decreases p(HGNC:MAP2K2) |
| pubmed:23393546 | a(CHEBI:U0126) decreases p(HGNC:MAP2K2) |
| pubmed:30515821 | a(CHEBI:U0126) decreases path(DOID:"Huntington's disease") |
| pubmed:30515821 | a(CHEBI:U0126) regulates path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | a(CHEBI:U0126) positiveCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | a(CHEBI:U0126) decreases a(CHEBI:"reactive oxygen species") |
| pubmed:30515821 | a(CHEBI:U0126) regulates bp(GO:"mitochondrial depolarization") |
| pubmed:23393546 | a(CHEBI:U0126) decreases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23393546 | a(CHEBI:U0126) decreases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30515821 | p(HGNC:DNM1L, var("p.Ser616Ala")) decreases path(DOID:"Huntington's disease") |
| pubmed:30515821 | p(HGNC:DNM1L, var("p.Ser616Ala")) regulates path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | p(HGNC:DNM1L, var("p.Ser616Ala")) positiveCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | p(HGNC:DNM1L, var("p.Ser616Ala")) increases a(CHEBI:"reactive oxygen species") |
| pubmed:30515821 | path(DOID:"brain ischemia") increases p(HGNC:AKAP1, loc(GO:mitochondrion)) |
| pubmed:30515821 | p(HGNC:AKAP1, loc(GO:mitochondrion)) decreases bp(GO:"mitochondrial fission") |
| pubmed:30515821 | p(HGNC:AKAP1, loc(GO:mitochondrion)) decreases a(CHEBI:"reactive oxygen species") |
| pubmed:30515821 | p(HGNC:AKAP1, loc(GO:mitochondrion)) regulates bp(GO:"calcium ion homeostasis") |
| pubmed:30515821 | p(HGNC:AKAP1) decreases p(HGNC:DNM1L, loc(GO:mitochondrion)) |
| pubmed:30515821 | p(HGNC:AKAP1) increases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 637)) |
| pubmed:30515821 | p(HGNC:AKAP1) increases path(MESH:Neuroprotection) |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 637)) increases path(MESH:Neuroprotection) |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 637)) decreases complex(GO:"calcium- and calmodulin-dependent protein kinase complex") |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 637)) decreases bp(GO:"necroptotic process") |
| pubmed:30515821 | p(HGNC:SIAH2) decreases r(FPLX:PKA) |
| pubmed:30515821 | p(HGNC:SIAH2) decreases complex(p(HGNC:DNM1L), p(HGNC:FIS1)) |
| pubmed:30515821 | p(HGNC:SIAH2) decreases r(HGNC:AKAP1) |
| pubmed:30515821 | r(FPLX:PKA) increases r(HGNC:AKAP1) |
| pubmed:30515821 | a(CHEBI:"L-glutamate(1-)") decreases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 637)) |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 40)) regulates path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 44)) regulates path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | p(FPLX:PKA) increases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 656)) |
| pubmed:26813123 | p(FPLX:PKA) increases p(FPLX:CHRN, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | p(FPLX:PKA) increases p(HGNC:PPP2R5A, pmod(go:0006468 ! "protein phosphorylation", Ser)) |
| pubmed:24653673 | p(FPLX:PKA) increases p(HGNC:PPP2R5D, pmod(go:0006468 ! "protein phosphorylation", Ser)) |
| pubmed:12428809 | p(FPLX:PKA) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29191965 | p(FPLX:PKA) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26195256 | p(FPLX:PKA) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26631930 | p(FPLX:PKA) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22908190 | act(p(FPLX:PKA)) increases p(HGNC:UCHL1) |
| pubmed:30116051 | act(p(FPLX:PKA), ma(go:0016301 ! "kinase activity")) increases p(HGNC:PSMC5, pmod(go:0006468 ! "protein phosphorylation", Ser, 120)) |
| pubmed:25331948 | p(FPLX:PKA) regulates p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:25331948 | p(FPLX:PKA) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:25331948 | act(p(FPLX:PKA)) increases p(HGNC:CREB1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26631930 | p(FPLX:PKA) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:23001711 | act(p(FPLX:PKA), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:17493042 | p(FPLX:PKA) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) |
| pubmed:26692334 | act(p(FPLX:PKA)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) |
| pubmed:17078951 | p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) |
| pubmed:17078951 | p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:17078951 | p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:17078951 | p(FPLX:PKA) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:17078951 | p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:17078951 | p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 217)) |
| pubmed:17078951 | p(FPLX:PKA) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 217)) |
| pubmed:17078951 | p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:17078951 | p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:17078951 | p(FPLX:PKA) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:17078951 | p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:17078951 | p(FPLX:PKA) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:17078951 | p(FPLX:PKA) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:17078951 | p(FPLX:PKA) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) |
| pubmed:17078951 | p(FPLX:PKA) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) |
| pubmed:17078951 | p(FPLX:PKA) regulates act(p(HGNC:GSK3B)) |
| pubmed:17078951 | p(FPLX:PKA) regulates act(p(HGNC:CDK5)) |
| pubmed:26692334 | act(p(FPLX:PKA)) increases act(complex(GO:"proteasome complex")) |
| pubmed:26692334 | act(p(FPLX:PKA)) decreases a(CONSO:"Tau aggregates") |
| pubmed:26692334 | act(p(FPLX:PKA)) increases bp(GO:cognition) |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 656)) decreases act(p(HGNC:DNM1L)) |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 656)) decreases bp(GO:"mitochondrial fission") |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 656)) increases path(MESH:Neuroprotection) |
| pubmed:30515821 | complex(complex(GO:"calcineurin complex"), p(HGNC:PPP2CA)) decreases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 656)) |
| pubmed:30515821 | complex(complex(GO:"calcineurin complex"), p(HGNC:PPP2CA)) increases act(p(HGNC:DNM1L)) |
| pubmed:26968346 | complex(GO:"calcineurin complex") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:26968346 | act(complex(GO:"calcineurin complex")) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:26968346 | act(complex(GO:"calcineurin complex")) decreases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30515821 | bp(GO:"response to oxygen-glucose deprivation") increases bp(GO:"cell death") |
| pubmed:30515821 | bp(GO:"response to oxygen-glucose deprivation") increases deg(p(HGNC:SENP3)) |
| pubmed:30515821 | bp(GO:"response to oxygen-glucose deprivation") increases p(HGNC:DNM1) |
| pubmed:30515821 | bp(GO:"response to oxygen-glucose deprivation") increases act(p(HGNC:DNM1)) |
| pubmed:30515821 | bp(GO:"response to oxygen-glucose deprivation") increases p(HGNC:PRKN) |
| pubmed:30515821 | bp(GO:"response to oxygen-glucose deprivation") increases act(p(HGNC:PRKN)) |
| pubmed:30515821 | bp(GO:"response to oxygen-glucose deprivation") decreases p(HGNC:PINK1) |
| pubmed:30515821 | complex(p(FPLX:PKA), p(HGNC:AKAP1)) increases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 656)) |
| pubmed:30515821 | complex(p(FPLX:PKA), p(HGNC:AKAP1)) regulates path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | complex(p(FPLX:PKA), p(HGNC:AKAP1)) increases bp(GO:"dendritic cell dendrite assembly") |
| pubmed:30515821 | complex(p(FPLX:PKA), p(HGNC:AKAP1)) decreases a(GO:synapse) |
| pubmed:30515821 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R2B)) decreases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 656)) |
| pubmed:23454242 | p(HGNC:PPP2R2B) association a(MESH:Cytosol) |
| pubmed:23454242 | p(HGNC:PPP2R2B) increases bp(GO:cytokinesis) |
| pubmed:23454242 | p(HGNC:PPP2R2B) association bp(GO:"cytoskeleton organization") |
| pubmed:30515821 | p(HGNC:SENP3) increases deg(p(HGNC:SUMO2)) |
| pubmed:30515821 | p(HGNC:SENP3) increases deg(p(HGNC:SUMO3)) |
| pubmed:18675254 | p(HGNC:SUMO2) increases p(HGNC:APP, pmod(go:0016925 ! "protein sumoylation", Lys, 587)) |
| pubmed:18675254 | p(HGNC:SUMO2) increases p(HGNC:APP, pmod(go:0016925 ! "protein sumoylation", Lys, 595)) |
| pubmed:17346237 | p(HGNC:SUMO3) increases p(HGNC:BACE1) |
| pubmed:17346237 | p(HGNC:SUMO3) increases p(HGNC:APP) |
| pubmed:17346237 | p(HGNC:SUMO3) increases tloc(p(HGNC:APP, frag("672_711")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17346237 | p(HGNC:SUMO3) increases tloc(p(HGNC:APP, frag("672_713")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:12506199 | p(HGNC:SUMO3) decreases a(CHEBI:amyloid-beta) |
| pubmed:12506199 | p(HGNC:SUMO3) increases p(HGNC:APP, pmod(CONSO:polysumoylation)) |
| pubmed:30515821 | p(HGNC:DNM1, pmod(go:0016925 ! "protein sumoylation")) decreases bp(GO:"release of cytochrome c from mitochondria") |
| pubmed:30515821 | p(HGNC:DNM1, pmod(go:0016925 ! "protein sumoylation")) decreases bp(GO:"programmed cell death") |
| pubmed:30515821 | p(HGNC:DNM1, pmod(go:0016925 ! "protein sumoylation")) decreases tloc(p(HGNC:DNM1L), fromLoc(GO:cytosol), toLoc(GO:"mitochondrial outer membrane")) |
| pubmed:30515821 | p(HGNC:DNM1, pmod(go:0016925 ! "protein sumoylation")) decreases bp(GO:"mitochondrial fission") |
| pubmed:30515821 | p(HGNC:DNM1, pmod(go:0016925 ! "protein sumoylation")) increases path(MESH:Neuroprotection) |
| pubmed:30515821 | p(HGNCGENEFAMILY:Caspases) increases bp(GO:"programmed cell death") |
| pubmed:23516100 | act(p(HGNCGENEFAMILY:Caspases)) increases p(HGNC:HTT, frag("?")) |
| pubmed:23516100 | act(p(HGNCGENEFAMILY:Caspases)) increases p(HGNC:HTT, frag("?")) |
| pubmed:23516100 | act(p(HGNCGENEFAMILY:Caspases)) increases p(HGNC:ATXN3, frag("?")) |
| pubmed:23516100 | act(p(HGNCGENEFAMILY:Caspases)) increases p(HGNC:ATXN3, frag("?"), var("?")) |
| pubmed:24027553 | act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT)) |
| pubmed:24027553 | act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT)) |
| pubmed:24027553 | act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT)) |
| pubmed:24027553 | act(p(HGNCGENEFAMILY:Caspases)) positiveCorrelation path(MESH:"Neurofibrillary Tangles") |
| pubmed:24027553 | act(p(HGNCGENEFAMILY:Caspases)) association path(MESH:"Neurofibrillary Tangles") |
| pubmed:24027553 | act(p(HGNCGENEFAMILY:Caspases)) increases a(CONSO:"Tau aggregates") |
| pubmed:24027553 | act(p(HGNCGENEFAMILY:Caspases)) increases p(HGNC:MAPT, frag("?")) |
| pubmed:30515821 | complex(p(HGNC:DNM1), p(HGNC:PRKN)) increases p(HGNC:DNM1, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:30515821 | complex(p(HGNC:DNM1), p(HGNC:PRKN)) decreases act(p(HGNC:DNM1)) |
| pubmed:30515821 | path(OMIT:0016183) increases p(HGNC:DNM1) |
| pubmed:30515821 | path(OMIT:0016183) increases act(p(HGNC:DNM1)) |
| pubmed:30515821 | path(OMIT:0016183) increases p(HGNC:PRKN) |
| pubmed:30515821 | path(OMIT:0016183) increases act(p(HGNC:PRKN)) |
| pubmed:30515821 | composite(p(HGNC:DNM1), p(HGNC:PRKN)) regulates path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | composite(p(HGNC:DNM1), p(HGNC:PRKN)) increases act(p(HGNC:PRKN)) |
| pubmed:30515821 | p(HGNC:DNM1, pmod(go:0017014 ! "protein nitrosylation", Cys, 644)) increases act(p(HGNC:DNM1), ma(GO:"GTPase activity")) |
| pubmed:30515821 | p(HGNC:DNM1, pmod(go:0017014 ! "protein nitrosylation", Cys, 644)) decreases a(MESH:"Dendritic Spines") |
| pubmed:30515821 | p(HGNC:DNM1, pmod(go:0017014 ! "protein nitrosylation", Cys, 644)) decreases path(MESH:"Wounds and Injuries") |
| pubmed:30515821 | p(HGNC:DNM1, pmod(go:0017014 ! "protein nitrosylation", Cys, 644)) negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | p(HGNC:DNM1, pmod(go:0017014 ! "protein nitrosylation", Cys, 644)) increases path(DOID:"Huntington's disease") |
| pubmed:30515821 | p(NCBIGENE:15194, var("?")) increases a(CHEBI:"nitric oxide") |
| pubmed:30515821 | p(NCBIGENE:74006, pmod(go:0017014 ! "protein nitrosylation", Cys, 644)) decreases a(MESH:"Dendritic Spines") |
| pubmed:30515821 | p(NCBIGENE:74006, pmod(go:0017014 ! "protein nitrosylation", Cys, 644)) decreases path(MESH:"Wounds and Injuries") |
| pubmed:30515821 | p(HGNC:DNM1, var("p.Cys644Ala")) decreases p(HGNC:DNM1, pmod(go:0017014 ! "protein nitrosylation", Cys, 644)) |
| pubmed:30515821 | path(OMIT:0010462) positiveCorrelation p(HGNC:DNM1) |
| pubmed:30515821 | bp(GO:"synaptic vesicle cycle") positiveCorrelation p(HGNC:DNM1) |
| pubmed:30515821 | bp(GO:"negative regulation of mitophagy") negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | bp(GO:"negative regulation of mitophagy") increases path(OMIT:0002643) |
| pubmed:30515821 | composite(p(HGNC:DNM1), p(HGNC:SQSTM1)) decreases a(OMIT:0012627) |
| pubmed:30515821 | composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) increases bp(GO:"mitochondrial fission") |
| pubmed:30515821 | composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) increases deg(a(GO:synapse)) |
| pubmed:30515821 | composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) negativeCorrelation bp(GO:"axonal transport") |
| pubmed:30515821 | composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) increases path(DOID:"Alzheimer's disease") |
| pubmed:30515821 | composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) decreases p(HGNC:DNM1) |
| pubmed:30515821 | composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) decreases p(HGNC:FIS1) |
| pubmed:30515821 | composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) increases p(HGNC:MFN1) |
| pubmed:30515821 | composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) increases p(HGNC:MFN2) |
| pubmed:30515821 | composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) increases p(HGNC:OPA1) |
| pubmed:30515821 | composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) increases p(HGNC:NRF1) |
| pubmed:30515821 | composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) increases p(HGNC:NFE2L2) |
| pubmed:30515821 | composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) increases p(HGNC:PPARGC1A) |
| pubmed:30515821 | composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) increases p(HGNC:TFAM) |
| pubmed:30515821 | composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) increases g(HGNC:SYP) |
| pubmed:30515821 | composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) increases g(HGNC:DLG4) |
| pubmed:30515821 | composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases bp(GO:"mitochondrial fission") |
| pubmed:30515821 | composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases deg(a(GO:synapse)) |
| pubmed:30515821 | composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) negativeCorrelation bp(GO:"axonal transport") |
| pubmed:30515821 | composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases path(DOID:"Alzheimer's disease") |
| pubmed:30515821 | composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) decreases p(HGNC:DNM1) |
| pubmed:30515821 | composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) decreases p(HGNC:FIS1) |
| pubmed:30515821 | composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases p(HGNC:MFN1) |
| pubmed:30515821 | composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases p(HGNC:MFN2) |
| pubmed:30515821 | composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases p(HGNC:OPA1) |
| pubmed:30515821 | composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases p(HGNC:NRF1) |
| pubmed:30515821 | composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases p(HGNC:NFE2L2) |
| pubmed:30515821 | composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases p(HGNC:PPARGC1A) |
| pubmed:30515821 | composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases p(HGNC:TFAM) |
| pubmed:30515821 | composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases g(HGNC:SYP) |
| pubmed:30515821 | composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases g(HGNC:DLG4) |
| pubmed:30515821 | bp(GO:"immunological synapse formation") positiveCorrelation p(HGNC:DNM1) |
| pubmed:30515821 | bp(GO:"immunological synapse formation") negativeCorrelation path(MESH:"Cell Aggregation") |
| pubmed:30515821 | path(MESH:"Cell Aggregation") negativeCorrelation bp(GO:"immunological synapse formation") |
| pubmed:30515821 | path(MESH:"Cell Aggregation") increases path(HP:"Abnormality of forebrain morphology") |
| pubmed:30515821 | p(HGNC:NRF1) increases a(MESH:Mitochondria) |
| pubmed:30515821 | p(HGNC:PPARGC1A) increases a(MESH:Mitochondria) |
| pubmed:27299292 | p(HGNC:PPARGC1A) increases a(MESH:Mitochondria) |
| pubmed:21718217 | p(HGNC:PPARGC1A) association bp(MESH:"Energy Metabolism") |
| pubmed:20556492 | p(HGNC:PPARGC1A) regulates bp(MESH:"Energy Metabolism") |
| pubmed:21718217 | p(HGNC:PPARGC1A) association path(MESH:"Insulin Resistance") |
| pubmed:21718217 | p(HGNC:PPARGC1A) increases bp(GO:"fat cell differentiation") |
| pubmed:20556492 | p(HGNC:PPARGC1A) regulates bp(MESH:"Mitochondrial Dynamics") |
| pubmed:20556492 | p(HGNC:PPARGC1A) regulates bp(GO:"mitochondrion organization") |
| pubmed:20556492 | p(HGNC:PPARGC1A) regulates bp(GO:"cellular respiration") |
| pubmed:20556492 | p(HGNC:PPARGC1A) increases a(CHEBI:"reactive oxygen species") |
| pubmed:20556492 | p(HGNC:PPARGC1A) regulates bp(GO:detoxification) |
| pubmed:20556492 | p(HGNC:PPARGC1A) regulates bp(MESH:Thermogenesis) |
| pubmed:26968346 | p(HGNC:PPARGC1A) positiveCorrelation bp(GO:"nervous system process") |
| pubmed:26968346 | p(HGNC:PPARGC1A) increases p(HGNC:TFEB) |
| pubmed:27299292 | p(HGNC:PPARGC1A) regulates p(HGNC:TFEB) |
| pubmed:27299292 | act(p(HGNC:PPARGC1A)) regulates act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:27299292 | p(HGNC:PPARGC1A) increases act(p(HGNC:TFEB)) |
| pubmed:27299292 | p(HGNC:PPARGC1A) association bp(GO:"insulin receptor signaling pathway") |
| pubmed:27299292 | p(HGNC:PPARGC1A) association p(MESH:"AMP-Activated Protein Kinases") |
| pubmed:27299292 | p(HGNC:PPARGC1A) association complex(MESH:"Mechanistic Target of Rapamycin Complex 1") |
| pubmed:27299292 | p(HGNC:PPARGC1A) association complex(MESH:"Mechanistic Target of Rapamycin Complex 2") |
| pubmed:27299292 | p(HGNC:PPARGC1A) regulates r(HGNC:TFEB) |
| pubmed:27299292 | p(HGNC:PPARGC1A) increases r(HGNC:TFEB) |
| pubmed:27299292 | p(HGNC:PPARGC1A) increases r(HGNC:TFEB) |
| pubmed:27299292 | act(p(HGNC:PPARGC1A), ma(GO:"core promoter binding")) increases complex(p(HGNC:PPARGC1A), r(HGNC:TFEB)) |
| pubmed:27299292 | act(p(HGNC:PPARGC1A)) increases complex(p(HGNC:PPARGC1A), p(HGNC:RXRA), r(HGNC:TFEB)) |
| pubmed:30515821 | p(HGNC:TFAM) increases a(MESH:Mitochondria) |
| pubmed:29238289 | a(MESH:"Transport Vesicles") association tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30515821 | complex(p(HGNC:DNM1), p(HGNC:LRRK2, var("p.Gly2019Ser"))) increases p(HGNC:DNM1, pmod(go:0006468 ! "protein phosphorylation", Thr, 595)) |
| pubmed:30515821 | complex(p(HGNC:DNM1), p(HGNC:LRRK2, var("p.Gly2019Ser"))) increases p(HGNC:DNM1, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) |
| pubmed:30515821 | p(HGNC:DNM1, pmod(go:0006468 ! "protein phosphorylation", Thr, 595)) increases act(p(HGNC:DNM1)) |
| pubmed:30515821 | p(HGNC:DNM1, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) increases act(p(HGNC:DNM1)) |
| pubmed:30515821 | act(a(NCIT:C12616)) increases p(HGNC:LRRK2) |
| pubmed:30515821 | p(HGNC:LRRK2, var("p.Glu192Lys")) causesNoChange act(p(HGNC:LRRK2), ma(GO:"kinase activity")) |
| pubmed:30515821 | p(HGNC:LRRK2, var("p.Glu192Lys")) causesNoChange act(p(HGNC:DNM1)) |
| pubmed:30515821 | p(HGNC:LRRK2, var("p.Glu192Lys")) association p(HGNC:LRRK2, pmod(go:0006468 ! "protein phosphorylation", Ser, 935)) |
| pubmed:30515821 | p(HGNC:LRRK2, var("p.Glu192Lys")) increases a(CHEBI:N-methyl-4-phenylpyridinium) |
| pubmed:30515821 | p(HGNC:LRRK2, var("p.Glu192Lys")) decreases complex(p(HGNC:DNM1), p(HGNC:LRRK2)) |
| pubmed:30515821 | p(HGNC:LRRK2, var("p.Glu192Lys")) decreases bp(GO:"mitochondrial fission") |
| pubmed:30515821 | p(HGNC:LRRK2, pmod(go:0006468 ! "protein phosphorylation", Ser, 935)) association p(HGNC:LRRK2, var("p.Glu192Lys")) |
| pubmed:30515821 | a(CHEBI:N-methyl-4-phenylpyridinium) association a(MESH:Mitochondria) |
| pubmed:19293145 | act(a(CHEBI:N-methyl-4-phenylpyridinium)) increases path(CONSO:neurotoxicity) |
| pubmed:26968346 | a(CHEBI:N-methyl-4-phenylpyridinium) increases bp(GO:"cell death") |
| pubmed:30515821 | p(HGNC:PINK1) decreases bp(GO:"mitochondrial fission") |
| pubmed:30515821 | p(HGNC:PINK1) decreases bp(GO:"mitochondrial fission") |
| pubmed:30515821 | p(HGNC:PINK1) positiveCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | p(HGNC:PINK1) decreases bp(GO:"neuron death") |
| pubmed:30515821 | p(HGNC:PINK1) increases a(CHEBI:ATP) |
| pubmed:30515821 | p(HGNC:PINK1) positiveCorrelation bp(OMIT:0025241) |
| pubmed:30515821 | p(HGNC:PINK1) decreases tloc(p(HGNC:DNM1L), fromLoc(GO:cytosol), toLoc(GO:"mitochondrial outer membrane")) |
| pubmed:30515821 | p(HGNC:PINK1) decreases path(DOID:ischemia) |
| pubmed:30688256 | p(HGNC:PINK1) decreases path(HBP:"mitochondrial dysfunction") |
| pubmed:30688256 | p(HGNC:PINK1) decreases bp(GO:"apoptotic process") |
| pubmed:30688256 | p(HGNC:PINK1) decreases bp(GO:"apoptotic process") |
| pubmed:30688256 | p(HGNC:PINK1) increases act(p(HGNC:PRKN)) |
| pubmed:30688256 | p(HGNC:PINK1, loc(GO:"mitochondrial outer membrane")) increases act(p(HGNC:PRKN)) |
| pubmed:21722302 | p(HGNC:PINK1) increases p(HGNC:PRKN) |
| pubmed:30688256 | p(HGNC:PINK1) association path(MESH:"Neurodegenerative Diseases") |
| pubmed:30688256 | p(HGNC:PINK1) association path(MESH:"Parkinson Disease") |
| pubmed:30688256 | p(HGNC:PINK1, loc(GO:"mitochondrial inner membrane")) increases deg(p(HGNC:PINK1)) |
| pubmed:30688256 | p(HGNC:PINK1) increases act(a(MESH:Mitochondria)) |
| pubmed:30688256 | p(HGNC:PINK1) decreases path(MESH:"Oxidative Stress") |
| pubmed:30688256 | p(HGNC:PINK1) increases bp(GO:mitophagy) |
| pubmed:30027901 | p(HGNC:PINK1) decreases bp(GO:mitophagy) |
| pubmed:26968346 | p(HGNC:PINK1) association bp(GO:mitophagy) |
| pubmed:30027901 | p(HGNC:PINK1) decreases bp(GO:"mitochondrial fragmentation involved in apoptotic process") |
| pubmed:21722302 | p(HGNC:PINK1) decreases bp(MESH:"Oxidative Stress") |
| pubmed:21722302 | p(HGNC:PINK1) decreases path(CONSO:"mitochondrial dysfunction") |
| pubmed:21722302 | p(HGNC:PINK1) decreases bp(MESH:Apoptosis) |
| pubmed:21722302 | p(HGNC:PINK1) regulates bp(MESH:"Protein Stability") |
| pubmed:26968346 | p(HGNC:PINK1) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:26968346 | p(HGNC:PINK1) increases act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:27299292 | p(HGNC:PINK1) association composite(p(HGNC:MITF), p(HGNC:TFE3), p(HGNC:TFEB)) |
| pubmed:30515821 | composite(a(CHEBI:"nitric oxide"), a(CHEBI:N-methyl-4-phenylpyridinium)) increases p(HGNC:DNM1) |
| pubmed:30515821 | composite(a(CHEBI:"nitric oxide"), a(CHEBI:N-methyl-4-phenylpyridinium)) increases p(HGNC:PRKN, pmod(go:0017014 ! "protein nitrosylation")) |
| pubmed:30515821 | p(HGNC:PRKN, pmod(go:0017014 ! "protein nitrosylation")) decreases deg(p(HGNC:DNM1)) |
| pubmed:30515821 | bp(OMIT:0025241) positiveCorrelation p(HGNC:PINK1) |
| pubmed:30515821 | bp(OMIT:0025241) negativeCorrelation p(HGNC:PINK1, var("p.Try437?")) |
| pubmed:30515821 | bp(OMIT:0025241) negativeCorrelation p(HGNC:PINK1, var("p.Lys219Met")) |
| pubmed:30515821 | p(HGNC:PINK1, var("p.Try437?")) negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | p(HGNC:PINK1, var("p.Try437?")) increases bp(GO:"neuron death") |
| pubmed:30515821 | p(HGNC:PINK1, var("p.Try437?")) decreases a(CHEBI:ATP) |
| pubmed:30515821 | p(HGNC:PINK1, var("p.Try437?")) negativeCorrelation bp(OMIT:0025241) |
| pubmed:30515821 | p(HGNC:PINK1, var("p.Lys219Met")) negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | p(HGNC:PINK1, var("p.Lys219Met")) increases bp(GO:"neuron death") |
| pubmed:30515821 | p(HGNC:PINK1, var("p.Lys219Met")) decreases a(CHEBI:ATP) |
| pubmed:30515821 | p(HGNC:PINK1, var("p.Lys219Met")) negativeCorrelation bp(OMIT:0025241) |
| pubmed:27190210 | path(DOID:ischemia) association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:21861815 | path(DOID:ischemia) increases path(DOID:"Alzheimer's disease") |
| pubmed:30515821 | complex(p(HGNC:DNM1L), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | complex(p(HGNC:DNM1L), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) negativeCorrelation bp(GO:"axonal transport") |
| pubmed:30515821 | complex(p(HGNC:DNM1L), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) increases path(DOID:"Huntington's disease") |
| pubmed:30515821 | complex(p(HGNC:DNM1L), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) increases act(p(HGNC:DNM1L)) |
| pubmed:30515821 | complex(p(HGNC:DNM1L), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) increases act(p(HGNC:DNM1L), ma(GO:"GTPase activity")) |
| pubmed:30515821 | complex(p(HGNC:DNM1L), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) increases bp(GO:"mitochondrial fission") |
| pubmed:30515821 | complex(p(HGNC:DNM1L), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) increases bp(GO:"neuron death") |
| pubmed:30515821 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases a(CHEBI:"nitric oxide") |
| pubmed:30515821 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases bp(GO:"mitochondrial fission") |
| pubmed:30515821 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases path(MESH:"Wounds and Injuries") |
| pubmed:30362565 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases a(CONSO:"huntingtin aggregates") |
| pubmed:30027901 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases a(CONSO:"huntingtin aggregates") |
| pubmed:30027901 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases a(CONSO:"huntingtin aggregates") |
| pubmed:30027901 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases a(CONSO:"huntingtin aggregates") |
| pubmed:30362565 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases bp(GO:"mRNA transcription") |
| pubmed:30362565 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases bp(GO:"mRNA transcription") |
| pubmed:30027901 | act(p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) decreases bp(GO:"mRNA transcription") |
| pubmed:30362565 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases path(MESH:"Energy Metabolism") |
| pubmed:30362565 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases path(MESH:"Oxidative Stress") |
| pubmed:30362565 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases path(MESH:"Oxidative Stress") |
| pubmed:30362565 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases path(MESH:"Organelle Biogenesis") |
| pubmed:30362565 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases path(MESH:"Mitochondrial Dynamics") |
| pubmed:21861815 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) negativeCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30362565 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases bp(GO:"metabolic process") |
| pubmed:30362565 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases act(p(HGNCGENEFAMILY:"Pyruvate dehydrogenase complex")) |
| pubmed:30362565 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases path(MESH:"Lipid Metabolism") |
| pubmed:22179319 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases path(CONSO:neurotoxicity) |
| pubmed:22179319 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) association path(MESH:Eating) |
| pubmed:22179319 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases path(MESH:Neuroprotection) |
| pubmed:22179319 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases p(HGNC:NTRK2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22179319 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases p(HGNC:NTRK2) |
| pubmed:22179319 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases p(HGNC:FOXO3) |
| pubmed:22179319 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases p(HGNC:FOXO3, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:22179319 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases p(HGNC:TP53, pmod(go:0006473 ! "protein acetylation", Lys, 382)) |
| pubmed:22179319 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) association p(HGNC:SIRT1, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:20556492 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pubmed:20556492 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases tloc(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits"), fromLoc(GO:cytoplasm), toLoc(GO:"plasma membrane")) |
| pubmed:20556492 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases path(MESH:"Cytotoxicity, Immunologic") |
| pubmed:20556492 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases r(HGNC:PPARGC1A) |
| pubmed:30027901 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases path(MESH:"Huntington Disease") |
| pubmed:30027901 | act(p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) increases bp(MESH:"Oxidative Stress") |
| pubmed:30027901 | act(p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) increases bp(GO:autophagy) |
| pubmed:30027901 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases bp(GO:autophagy) |
| pubmed:30027901 | act(p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) increases bp(CONSO:"protein aggregation") |
| pubmed:30027901 | act(p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) decreases bp(GO:"cellular homeostasis") |
| pubmed:30027901 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases bp(GO:"cell death") |
| pubmed:30027901 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) regulates bp(GO:"cell death") |
| pubmed:30027901 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases p(INTERPRO:"Pathogenicity locus") |
| pubmed:30027901 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases a(GO:"inclusion body", loc(MESH:Neurons)) |
| pubmed:30027901 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases complex(p(HGNC:HTT, pmod(CONSO:"CAG repeats")), p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"))) |
| pubmed:30027901 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) regulates bp(MESH:"Cell Survival") |
| pubmed:23393546 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases bp(MESH:"Cell Survival") |
| pubmed:30027901 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases bp(MESH:Apoptosis) |
| pubmed:30027901 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases bp(GO:"nuclear pore complex assembly") |
| pubmed:30027901 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases tloc(a(MESH:Autophagosomes), fromLoc(GO:"distal axon"), toLoc(GO:"cell body")) |
| pubmed:30027901 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases p(HGNC:MTOR) |
| pubmed:26968346 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases p(HGNC:MTOR) |
| pubmed:30027901 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases bp(CONSO:Proteostasis) |
| pubmed:30027901 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases p(MESH:"HSP70 Heat-Shock Proteins") |
| pubmed:30027901 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) causesNoChange p(MESH:"HSP70 Heat-Shock Proteins") |
| pubmed:23393546 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases bp(GO:"ERK1 and ERK2 cascade") |
| pubmed:23393546 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases p(HGNC:NF2) |
| pubmed:23393546 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases bp(GO:"MAPK cascade") |
| pubmed:23393546 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases bp(GO:"MAPK cascade") |
| pubmed:23393546 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases bp(GO:"motor behavior") |
| pubmed:23393546 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases path(CONSO:Neurodegeneration) |
| pubmed:23393546 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases path(MESH:"Striatal Degeneration, Autosomal Dominant") |
| pubmed:23393546 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases p(HGNC:PPP1R1B) |
| pubmed:26968346 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases p(HGNC:BECN1) |
| pubmed:27299292 | p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases r(HGNC:TFEB) |
| pubmed:30515821 | complex(p(HGNC:DNM1L, var("p.Lys38Ala")), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) positiveCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | complex(p(HGNC:DNM1L, var("p.Lys38Ala")), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) positiveCorrelation bp(GO:"axonal transport") |
| pubmed:30515821 | complex(p(HGNC:DNM1L, var("p.Lys38Ala")), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) decreases bp(GO:"neuron death") |
| pubmed:30515821 | p(NCBIGENE:15194, pmod(CONSO:"CAG repeats")) increases a(CHEBI:"nitric oxide") |
| pubmed:30515821 | p(NCBIGENE:15194, pmod(CONSO:"CAG repeats")) increases p(NCBIGENE:74006, pmod(go:0017014 ! "protein nitrosylation")) |
| pubmed:30515821 | p(NCBIGENE:74006, pmod(go:0017014 ! "protein nitrosylation")) increases bp(GO:"mitochondrial fission") |
| pubmed:30515821 | p(NCBIGENE:74006, pmod(go:0017014 ! "protein nitrosylation")) increases bp(GO:"neuron death") |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0017014 ! "protein nitrosylation")) increases bp(GO:"mitochondrial fission") |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0017014 ! "protein nitrosylation")) increases bp(GO:"neuron death") |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0017014 ! "protein nitrosylation")) increases complex(p(HGNC:DNM1L), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) |
| pubmed:30515821 | p(HGNC:DNM1L, pmod(go:0017014 ! "protein nitrosylation")) increases path(MESH:"Wounds and Injuries") |
| pubmed:30515821 | p(HGNC:DNM1L, var("p.Cys644Ala")) decreases bp(GO:"mitochondrial fission") |
| pubmed:30515821 | p(HGNC:DNM1L, var("p.Cys644Ala")) decreases path(MESH:"Wounds and Injuries") |
| pubmed:30515821 | p(HGNC:DNM1L, var("p.Cys644Ala")) positiveCorrelation path(MESH:"Mitochondrial Dynamics") |
| pubmed:30515821 | complex(p(HGNC:DNM1L), p(HGNC:MAPK1)) increases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) |
| pubmed:30688256 | bp(GO:"mitochondrial depolarization") increases p(HGNC:PINK1, loc(GO:"mitochondrial inner membrane")) |
| pubmed:21722302 | bp(GO:"mitochondrial depolarization") increases p(HGNC:PINK1) |
| pubmed:30562574 | bp(GO:"mitochondrial depolarization") association p(HGNC:PARK7) |
| pubmed:30515821 | bp(NCIT:C17741) increases path(DOID:"motor neuron disease") |
| pubmed:30515821 | path(DOID:"motor neuron disease") negativeCorrelation bp(MESH:"Energy Metabolism") |
| pubmed:27181519 | path(DOID:"motor neuron disease") association p(HGNC:FUS) |
| pubmed:28669544 | path(DOID:"motor neuron disease") increases composite(a(MESH:Microglia), p(HGNC:TARDBP)) |
| pubmed:30515821 | p(HGNC:TAT, frag("47_57")) decreases complex(p(HGNC:DNM1L), p(HGNC:FIS1)) |
| pubmed:30515821 | p(HGNC:TAT, frag("47_57")) causesNoChange bp(GO:"mitochondrial fission") |
| pubmed:30515821 | p(HGNC:TAT, frag("47_57")) decreases a(CHEBI:"reactive oxygen species") |
| pubmed:30515821 | p(HGNC:TAT, frag("47_57")) decreases bp(GO:"neuron death") |
| pubmed:30515821 | p(HGNC:TAT, frag("47_57")) decreases path(DOID:"muscular atrophy") |
| pubmed:30515821 | p(HGNC:TAT, frag("47_57")) decreases path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates p(FPLX:PLC) |
| pubmed:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"3',5'-cyclic AMP") |
| pubmed:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"myo-inositol trisphosphate") |
| pubmed:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"calcium ion") |
| pubmed:24511233 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") regulates act(a(CHEBI:acetylcholine)) |
| pubmed:19721446 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") increases act(a(CHEBI:acetylcholine)) |
| pubmed:24511233 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") isA p(MESH:"Receptors, G-Protein-Coupled") |
| pubmed:24511233 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") regulates bp(GO:cognition) |
| pubmed:24590577 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:"Alzheimer Disease") |
| pubmed:24590577 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association bp(GO:memory) |
| pubmed:24590577 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:Attention) |
| pubmed:24590577 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:Nociception) |
| pubmed:24590577 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association bp(GO:"circadian sleep/wake cycle") |
| pubmed:24590577 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association a(MESH:"Cardiovascular System") |
| pubmed:24590577 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association a(MESH:Kidney) |
| pubmed:24590577 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association a(MESH:"Gastrointestinal Tract") |
| pubmed:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Electric Fish") |
| pubmed:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:19721446 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"synaptic transmission, dopaminergic") |
| pubmed:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19293145 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association path(MESH:"Alzheimer Disease") |
| pubmed:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation path(MESH:Schizophrenia) |
| pubmed:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation a(CHEBI:"kynurenic acid") |
| pubmed:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:anandamide) |
| pubmed:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:anandamide) |
| pubmed:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"cation transport") |
| pubmed:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases a(MESH:Sodium, loc(GO:intracellular)) |
| pubmed:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"membrane depolarization") |
| pubmed:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"positive regulation of voltage-gated calcium channel activity") |
| pubmed:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) |
| pubmed:29428175 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"endoplasmic reticulum"), toLoc(MESH:Cytoplasm)) |
| pubmed:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates bp(GO:"inflammatory response") |
| pubmed:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases bp(GO:"keratinocyte migration") |
| pubmed:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"phosphatidylinositol 3-kinase signaling") |
| pubmed:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"ERK1 and ERK2 cascade") |
| pubmed:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"receptor signaling pathway via JAK-STAT") |
| pubmed:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Mice, Inbred Strains") |
| pubmed:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Mice, Inbred Strains") |
| pubmed:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Rats, Inbred Strains") |
| pubmed:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") negativeCorrelation path(MESH:Aging) |
| pubmed:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:amyloid-beta) |
| pubmed:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") decreases act(a(CHEBI:amyloid-beta)) |
| pubmed:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:amyloid-beta) |
| pubmed:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates act(a(CHEBI:amyloid-beta)) |
| pubmed:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases act(a(CHEBI:amyloid-beta)) |
| pubmed:19293145 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:amyloid-beta) |
| pubmed:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") decreases path(CONSO:neurotoxicity) |
| pubmed:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association path(CONSO:neurotoxicity) |
| pubmed:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:nicotine) |
| pubmed:19293145 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases act(a(CHEBI:N-methyl-4-phenylpyridinium)) |
| pubmed:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases bp(MESH:Neuroprotection) |
| pubmed:19293145 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(FPLX:PI3K)) |
| pubmed:19293145 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association p(HGNC:JAK2) |
| pubmed:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association bp(GO:"calcium ion homeostasis") |
| pubmed:19293145 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association g(HGNC:APOE) |
| pubmed:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association p(HGNC:APOE) |
| pubmed:19293145 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association bp(GO:"apoptotic process") |
| pubmed:19293145 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24511233 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates act(a(CHEBI:acetylcholine)) |
| pubmed:19721446 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases act(a(CHEBI:acetylcholine)) |
| pubmed:22530628 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation path(MESH:"Memory Disorders") |
| pubmed:22530628 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association path(MESH:Attention) |
| pubmed:22530628 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association bp(GO:memory) |
| pubmed:29428175 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association bp(GO:"synaptic signaling") |
| pubmed:29428175 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association bp(GO:"learning or memory") |
| pubmed:30697142 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates bp(GO:"learning or memory") |
| pubmed:29428175 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association path(MESH:"Substance-Related Disorders") |
| pubmed:29428175 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association path(DOID:schizophrenia) |
| pubmed:29428175 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association path(DOID:"Alzheimer's disease") |
| pubmed:29428175 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates tloc(a(MESH:Cytokines), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:29428175 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association bp(MESH:"Immunity, Cellular") |
| pubmed:29428175 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association path(MESH:"Immune System Diseases") |
| pubmed:29428175 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association path(MESH:Inflammation) |
| pubmed:30697142 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases bp(MESH:Metabolism) |
| pubmed:19721446 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Peripheral Nervous System") |
| pubmed:19721446 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Central Nervous System") |
| pubmed:19721446 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:19721446 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases tloc(a(CHEBI:serotonin), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:19721446 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:19721446 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:cholesterol) |
| pubmed:19721446 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates bp(MESH:"Sensory Gating") |
| pubmed:19126755 | a(CHEBI:Muscarine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) |
| pubmed:19126755 | a(CHEBI:atropine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) |
| pubmed:19126755 | a(CHEBI:atropine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) |
| pubmed:19126755 | a(CHEBI:atropine) decreases bp(GO:"cell adhesion") |
| pubmed:26813123 | a(CHEBI:atropine) decreases act(p(FPLX:CHRM)) |
| pubmed:26751493 | p(FPLX:PLC) association p(CONSO:"projection domain") |
| pubmed:30697142 | a(CHEBI:"3',5'-cyclic AMP") increases a(CHEBI:"glutamate(2-)") |
| pubmed:20556492 | a(CHEBI:"3',5'-cyclic AMP") increases act(p(HGNC:CREBBP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:23393546 | a(CHEBI:"3',5'-cyclic AMP") regulates p(HGNC:PPP1R1B) |
| pubmed:29626319 | a(CHEBI:"3',5'-cyclic AMP") increases deg(p(HGNC:MAPT)) |
| pubmed:27190210 | a(CHEBI:"calcium ion") regulates p(HGNC:CHRNA7) |
| pubmed:29428175 | a(CHEBI:"calcium ion", loc(MESH:Cytoplasm)) regulates bp(GO:"cell differentiation") |
| pubmed:29428175 | a(CHEBI:"calcium ion", loc(MESH:Cytoplasm)) regulates bp(GO:"cell migration") |
| pubmed:29428175 | a(CHEBI:"calcium ion", loc(MESH:Cytoplasm)) regulates bp(GO:"synapse assembly") |
| pubmed:29428175 | a(CHEBI:"calcium ion", loc(MESH:Cytoplasm)) regulates a(GO:cytoskeleton) |
| pubmed:29428175 | a(CHEBI:"calcium ion", loc(MESH:Cytoplasm)) regulates a(GO:cytoskeleton) |
| pubmed:29428175 | a(CHEBI:"calcium ion", loc(MESH:Cytoplasm)) regulates act(p(HGNC:CAMK2B)) |
| pubmed:29428175 | a(CHEBI:"calcium ion", loc(MESH:Cytoplasm)) decreases p(HGNCGENEFAMILY:Calpains) |
| pubmed:29428175 | a(CHEBI:"calcium ion", loc(MESH:Cytoplasm)) decreases p(GO:spectrin) |
| pubmed:29428175 | a(CHEBI:"calcium ion", loc(MESH:Cytoplasm)) decreases bp(GO:"cytoskeleton organization") |
| pubmed:26979166 | tloc(a(CHEBI:"calcium ion"), fromLoc(GO:"pore complex"), toLoc(MESH:"Intracellular Space")) increases act(p(HGNCGENEFAMILY:"Ryanodine receptors")) |
| pubmed:26979166 | tloc(a(CHEBI:"calcium ion"), fromLoc(GO:"pore complex"), toLoc(MESH:"Intracellular Space")) increases act(p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors")) |
| pubmed:30697142 | a(CHEBI:"calcium ion") increases a(CHEBI:"glutamate(2-)") |
| pubmed:30697142 | a(CHEBI:"calcium ion") increases a(CHEBI:"3',5'-cyclic AMP") |
| pubmed:29758300 | a(CHEBI:"calcium ion") increases act(a(MESH:"Vacuolar Proton-Translocating ATPases")) |
| pubmed:19126755 | a(MESH:"Electric Fish") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19126755 | p(CONSO:alpha-Bungarotoxin) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19126755 | p(CONSO:alpha-Bungarotoxin) increases complex(p(CONSO:alpha-Bungarotoxin), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19126755 | p(CONSO:alpha-Bungarotoxin) decreases a(CHEBI:dopamine, loc(GO:"extracellular region")) |
| pubmed:27190210 | p(CONSO:alpha-Bungarotoxin) decreases p(HGNC:CHRNA7) |
| pubmed:29428175 | p(CONSO:alpha-Bungarotoxin) decreases p(HGNC:CHRNA7) |
| pubmed:29428175 | p(CONSO:alpha-Bungarotoxin) negativeCorrelation bp(GO:"regulation of presynaptic membrane potential") |
| pubmed:21482353 | p(CONSO:alpha-Bungarotoxin) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:21958873 | p(CONSO:alpha-Bungarotoxin) causesNoChange a(CHEBI:amyloid-beta) |
| pubmed:21958873 | p(CONSO:alpha-Bungarotoxin) decreases act(a(MESH:"Receptors, Nicotinic")) |
| pubmed:19126755 | bp(GO:signaling) association a(CHEBI:acetylcholine) |
| pubmed:19126755 | act(p(HGNC:CHAT)) directlyIncreases rxn(reactants(a(CHEBI:acetyl-CoA), a(CHEBI:choline)), products(a(CHEBI:acetylcholine))) |
| pubmed:26813123 | p(HGNC:CHAT) increases rxn(reactants(a(CHEBI:acetyl-CoA), a(CHEBI:choline)), products(a(CHEBI:acetylcholine))) |
| pubmed:16273023 | act(p(HGNC:CHAT), ma(go:0003824 ! "catalytic activity")) increases rxn(reactants(a(CHEBI:acetyl-CoA), a(CHEBI:choline)), products(a(CHEBI:acetylcholine))) |
| pubmed:19293145 | p(HGNC:CHAT) negativeCorrelation g(HGNC:APOE) |
| pubmed:26813123 | act(p(HGNC:CHAT)) negativeCorrelation path(MESH:"Huntington Disease") |
| pubmed:26813123 | act(p(HGNC:CHAT)) decreases path(MESH:Dementia) |
| pubmed:24590577 | p(HGNC:CHAT) decreases a(CHEBI:acetylcholine) |
| pubmed:25514383 | act(p(HGNC:CHAT)) increases a(CHEBI:acetylcholine) |
| pubmed:18986241 | act(p(HGNC:CHAT)) directlyIncreases a(CHEBI:acetylcholine) |
| pubmed:19721446 | p(HGNC:CHAT) increases a(CHEBI:acetylcholine) |
| pubmed:18986241 | act(p(HGNC:CHAT)) decreases path(CONSO:Neurodegeneration) |
| pubmed:9089387 | a(CHEBI:acetyl-CoA) increases a(CHEBI:acetylcholine) |
| pubmed:28002468 | a(CHEBI:acetyl-CoA) increases bp(CONSO:"cystein-dependent auto-acetylation") |
| pubmed:17009926 | a(CHEBI:choline) increases act(p(FPLX:CHRN)) |
| pubmed:26813123 | a(CHEBI:choline) increases a(CHEBI:acetylcholine) |
| pubmed:29428175 | a(CHEBI:choline) increases act(p(HGNC:CHRNA7)) |
| pubmed:26088141 | act(a(CHEBI:choline)) increases a(CHEBI:"calcium(2+)") |
| pubmed:26088141 | a(CHEBI:choline) increases a(CHEBI:"calcium(2+)") |
| pubmed:26088141 | act(a(CHEBI:choline)) association act(a(MESH:"Calcium Channels")) |
| pubmed:26088141 | a(CHEBI:choline) association bp(MESH:"Pleckstrin Homology Domains") |
| pubmed:26088141 | a(CHEBI:choline) increases bp(MESH:"Pleckstrin Homology Domains") |
| pubmed:26088141 | a(CHEBI:choline) decreases complex(p(FPLX:"G_protein"), p(HGNC:CHRNA7)) |
| pubmed:26088141 | a(CHEBI:choline) decreases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ)) |
| pubmed:26088141 | a(CHEBI:choline) decreases complex(p(HGNC:CHRNA7), p(HGNCGENEFAMILY:"G protein subunits beta")) |
| pubmed:21482353 | a(CHEBI:choline) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:21482353 | a(CHEBI:choline) increases act(p(CONSO:"alpha-7-containing nAChR")) |
| pubmed:19721446 | a(CHEBI:choline) increases bp(MESH:Neuroprotection) |
| pubmed:19721446 | a(CHEBI:choline) decreases act(a(MESH:"alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid")) |
| pubmed:26813123 | p(HGNC:CHRNA1) increases a(MESH:"Receptors, Nicotinic") |
| pubmed:19126755 | p(HGNC:CHRNA4) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:11230871 | p(HGNC:CHRNA4) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19126755 | p(HGNC:CHRNA4) association p(HGNC:PTGS2) |
| pubmed:19293145 | p(HGNC:CHRNA4) positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:17009926 | p(HGNC:CHRNA4) positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:19293145 | act(p(HGNC:CHRNA4)) decreases act(a(CHEBI:"L-glutamate(2-)")) |
| pubmed:19293145 | act(p(HGNC:CHRNA4)) increases act(a(CHEBI:nicotine)) |
| pubmed:19721446 | p(HGNC:CHRNA4) increases act(a(CHEBI:nicotine)) |
| pubmed:19293145 | p(HGNC:CHRNA4) association bp(GO:"lipid metabolic process") |
| pubmed:23038257 | p(HGNC:CHRNA4) association p(MESH:"Cytoskeletal Proteins") |
| pubmed:23038257 | p(HGNC:CHRNA4) association bp(GO:"intracellular receptor signaling pathway") |
| pubmed:17009926 | p(HGNC:CHRNA4) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:26813123 | p(HGNC:CHRNA4) increases a(MESH:"Receptors, Nicotinic") |
| pubmed:11230871 | p(HGNC:CHRNA4) decreases complex(a(CHEBI:cytisine), p(FPLX:CHRN)) |
| pubmed:26813123 | p(HGNC:CHRNB1) increases a(MESH:"Receptors, Nicotinic") |
| pubmed:26813123 | p(HGNC:CHRND) increases a(MESH:"Receptors, Nicotinic") |
| pubmed:19126755 | act(p(HGNC:CHRNG)) increases bp(GO:"long-term synaptic potentiation") |
| pubmed:26813123 | p(HGNC:CHRNG) increases a(MESH:"Receptors, Nicotinic") |
| pubmed:26813123 | p(HGNC:CHRNE) increases a(MESH:"Receptors, Nicotinic") |
| pubmed:26813123 | p(HGNC:CHRNA2) increases a(MESH:"Receptors, Nicotinic") |
| pubmed:19721446 | p(HGNC:CHRNA2) decreases act(a(CHEBI:nicotine)) |
| pubmed:26813123 | p(HGNC:CHRNA3) increases a(MESH:"Receptors, Nicotinic") |
| pubmed:11230871 | p(HGNC:CHRNA3) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:11230871 | p(HGNC:CHRNA3) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19721446 | p(HGNC:CHRNA3) association path(MESH:Craving) |
| pubmed:19721446 | p(HGNC:CHRNA3) association path(MESH:Recurrence) |
| pubmed:28901280 | p(HGNC:CHRNA3) positiveCorrelation bp(UBERON:0002138) |
| pubmed:19126755 | p(HGNC:CHRNA5) decreases path(MESH:"Inflammatory Bowel Diseases") |
| pubmed:26813123 | p(HGNC:CHRNA5) increases a(MESH:"Receptors, Nicotinic") |
| pubmed:19721446 | p(HGNC:CHRNA5) decreases act(a(CHEBI:nicotine)) |
| pubmed:28901280 | p(HGNC:CHRNA5) positiveCorrelation bp(UBERON:0002138) |
| pubmed:26813123 | p(HGNC:CHRNA6) increases a(MESH:"Receptors, Nicotinic") |
| pubmed:21787755 | p(HGNC:CHRNA6) association path(MESH:Reward) |
| pubmed:21787755 | p(HGNC:CHRNA6) association bp(MESH:"Drug Interactions") |
| pubmed:21787755 | p(HGNC:CHRNA6) association tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:19126755 | p(HGNC:CHRNA7) association a(MESH:Neurons) |
| pubmed:19126755 | p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA5), p(HGNC:CHRNA7)) |
| pubmed:19126755 | p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) |
| pubmed:19126755 | p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA7), p(HGNC:CHRNB3)) |
| pubmed:19126755 | act(p(HGNC:CHRNA7)) increases bp(GO:"action potential initiation") |
| pubmed:19126755 | act(p(HGNC:CHRNA7, loc(GO:"axon terminus"))) regulates bp(GO:"synaptic transmission, glycinergic") |
| pubmed:19126755 | act(p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) |
| pubmed:19126755 | act(p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) |
| pubmed:19293145 | act(p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") |
| pubmed:29428175 | p(HGNC:CHRNA7) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"endoplasmic reticulum"), toLoc(MESH:Cytoplasm)) |
| pubmed:29428175 | act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) increases a(CHEBI:"calcium(2+)", loc(MESH:Cytoplasm)) |
| pubmed:29428175 | act(p(HGNC:CHRNA7)) increases tloc(a(CHEBI:"calcium(2+)", loc(MESH:"Endoplasmic Reticulum")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:22040696 | p(HGNC:CHRNA7) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Cytoplasm)) |
| pubmed:19126755 | act(p(HGNC:CHRNA7)) increases bp(GO:"neuronal action potential") |
| pubmed:19126755 | act(p(HGNC:CHRNA7, loc(GO:"glutamatergic synapse"))) regulates bp(GO:"synaptic transmission, dopaminergic") |
| pubmed:19126755 | act(p(HGNC:CHRNA7, loc(GO:"glutamatergic synapse"))) increases a(CHEBI:"glutamate(2-)", loc(MESH:"Dopaminergic Neurons")) |
| pubmed:19126755 | p(HGNC:CHRNA7, loc(MESH:"Mossy Fibers, Hippocampal")) regulates a(CHEBI:"glutamate(2-)", loc(MESH:"Pyramidal Cells")) |
| pubmed:19293145 | act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:"glutamate(2-)")) |
| pubmed:17009926 | act(p(HGNC:CHRNA7)) increases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30697142 | p(HGNC:CHRNA7) increases a(CHEBI:"glutamate(2-)") |
| pubmed:19126755 | p(HGNC:CHRNA7) positiveCorrelation bp(GO:cognition) |
| pubmed:19126755 | act(p(HGNC:CHRNA7)) association bp(GO:cognition) |
| pubmed:27190210 | p(HGNC:CHRNA7) association bp(GO:cognition) |
| pubmed:27190210 | p(HGNC:CHRNA7) increases bp(GO:cognition) |
| pubmed:22530628 | p(HGNC:CHRNA7) increases bp(GO:cognition) |
| pubmed:30697142 | p(HGNC:CHRNA7) regulates bp(GO:cognition) |
| pubmed:19721446 | p(HGNC:CHRNA7) positiveCorrelation bp(GO:cognition) |
| pubmed:19721446 | act(p(HGNC:CHRNA7)) increases bp(GO:cognition) |
| pubmed:19126755 | p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19293145 | p(HGNC:CHRNA7) association path(MESH:"Alzheimer Disease") |
| pubmed:11230871 | p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22040696 | p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29191965 | p(HGNC:CHRNA7) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19126755 | act(p(HGNC:CHRNA7)) increases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:19126755 | act(p(HGNC:CHRNA7)) regulates a(CHEBI:dopamine, loc(GO:"extracellular region")) |
| pubmed:19126755 | act(p(HGNC:CHRNA7)) increases a(CHEBI:dopamine, loc(GO:"extracellular region")) |
| pubmed:19126755 | act(p(HGNC:CHRNA7)) association path(MESH:"Sensory Gating") |
| pubmed:19126755 | act(p(HGNC:CHRNA7)) increases a(CHEBI:amyloid-beta, loc(GO:intracellular)) |
| pubmed:19293145 | p(HGNC:CHRNA7) positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:19293145 | p(HGNC:CHRNA7) decreases act(a(CHEBI:amyloid-beta)) |
| pubmed:19293145 | p(HGNC:CHRNA7) increases a(CHEBI:amyloid-beta) |
| pubmed:19293145 | p(HGNC:CHRNA7) association a(CHEBI:amyloid-beta) |
| pubmed:17009926 | p(HGNC:CHRNA7) positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:26979166 | act(p(HGNC:CHRNA7, loc(MESH:Microglia))) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29191965 | p(HGNC:CHRNA7) regulates act(a(CHEBI:amyloid-beta)) |
| pubmed:19126755 | act(p(HGNC:CHRNA7)) increases a(CHEBI:anandamide) |
| pubmed:19126755 | p(HGNC:CHRNA7) regulates bp(GO:"cell cycle") |
| pubmed:19126755 | p(HGNC:CHRNA7) regulates bp(MESH:Apoptosis) |
| pubmed:27190210 | p(HGNC:CHRNA7) association bp(MESH:Apoptosis) |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) decreases bp(MESH:Apoptosis) |
| pubmed:19126755 | p(HGNC:CHRNA7) regulates bp(MESH:"Cell Differentiation") |
| pubmed:19126755 | act(p(HGNC:CHRNA7)) association a(CHEBI:nicotine) |
| pubmed:19126755 | p(HGNC:CHRNA7) regulates a(CHEBI:nicotine) |
| pubmed:19293145 | p(HGNC:CHRNA7) regulates act(a(CHEBI:nicotine)) |
| pubmed:19126755 | p(HGNC:CHRNA7) regulates path(MESH:"Substance Withdrawal Syndrome") |
| pubmed:19293145 | p(HGNC:CHRNA7) association path(MESH:"Plaque, Amyloid") |
| pubmed:19293145 | p(HGNC:CHRNA7) increases act(a(CHEBI:galanthamine)) |
| pubmed:19293145 | act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:ethanol)) |
| pubmed:19293145 | act(p(HGNC:CHRNA7)) decreases bp(GO:"cell death") |
| pubmed:19293145 | act(p(HGNC:CHRNA7)) increases a(CHEBI:glucose) |
| pubmed:19293145 | act(p(HGNC:CHRNA7)) increases a(MESH:Oxygen) |
| pubmed:19293145 | act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:"L-glutamate(2-)")) |
| pubmed:19293145 | act(p(HGNC:CHRNA7)) causesNoChange act(a(CHEBI:N-methyl-4-phenylpyridinium)) |
| pubmed:19293145 | act(p(HGNC:CHRNA7)) decreases act(p(HGNC:FAS)) |
| pubmed:19293145 | p(HGNC:CHRNA7) decreases path(CONSO:neurotoxicity) |
| pubmed:19293145 | act(p(HGNC:CHRNA7)) increases act(p(HGNC:JAK2)) |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) directlyIncreases act(p(HGNC:JAK2)) |
| pubmed:19293145 | p(HGNC:CHRNA7) increases bp(GO:"MAPK cascade") |
| pubmed:19293145 | p(HGNC:CHRNA7) increases bp(GO:"MAPK cascade") |
| pubmed:19293145 | act(p(HGNC:CHRNA7)) increases bp(GO:"calcium ion transport") |
| pubmed:27190210 | p(HGNC:CHRNA7) increases bp(GO:"calcium ion transport") |
| pubmed:27190210 | p(HGNC:CHRNA7) increases bp(GO:"calcium ion transport") |
| pubmed:30697142 | act(p(HGNC:CHRNA7)) increases bp(GO:"calcium ion transport") |
| pubmed:19293145 | act(p(HGNC:CHRNA7)) association bp(GO:"calcium-mediated signaling") |
| pubmed:29428175 | act(p(HGNC:CHRNA7)) increases bp(GO:"calcium-mediated signaling") |
| pubmed:19293145 | p(HGNC:CHRNA7) increases act(p(HGNCGENEFAMILY:"Ryanodine receptors")) |
| pubmed:19293145 | act(p(HGNC:CHRNA7)) increases tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:18986241 | p(HGNC:CHRNA7) increases complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) |
| pubmed:27190210 | p(HGNC:CHRNA7) association bp(GO:"learning or memory") |
| pubmed:27190210 | act(p(HGNC:CHRNA7)) increases bp(GO:"learning or memory") |
| pubmed:22530628 | p(HGNC:CHRNA7) increases bp(GO:"learning or memory") |
| pubmed:22530628 | p(HGNC:CHRNA7) increases bp(GO:"learning or memory") |
| pubmed:27190210 | p(HGNC:CHRNA7) association bp(MESH:Immunity) |
| pubmed:27190210 | p(HGNC:CHRNA7) association path(MESH:Inflammation) |
| pubmed:27190210 | p(HGNC:CHRNA7) increases path(MESH:Inflammation) |
| pubmed:27190210 | p(HGNC:CHRNA7) regulates path(MESH:Inflammation) |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) decreases path(MESH:Inflammation) |
| pubmed:26979166 | p(HGNC:CHRNA7) decreases path(MESH:Inflammation) |
| pubmed:26979166 | p(HGNC:CHRNA7) decreases path(MESH:Inflammation) |
| pubmed:26979166 | act(p(HGNC:CHRNA7, loc(MESH:Microglia))) decreases path(MESH:Inflammation) |
| pubmed:26979166 | act(p(HGNC:CHRNA7, loc(MESH:Macrophages))) decreases path(MESH:Inflammation) |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) decreases path(MESH:Inflammation) |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) decreases path(MESH:Inflammation) |
| pubmed:30697142 | p(HGNC:CHRNA7) decreases path(MESH:Inflammation) |
| pubmed:28901280 | p(HGNC:CHRNA7) regulates path(MESH:Inflammation) |
| pubmed:27190210 | p(HGNC:CHRNA7) association bp(MESH:Neuroprotection) |
| pubmed:27190210 | act(p(HGNC:CHRNA7)) increases bp(MESH:Neuroprotection) |
| pubmed:26979166 | p(HGNC:CHRNA7) increases bp(MESH:Neuroprotection) |
| pubmed:19721446 | p(HGNC:CHRNA7) association bp(MESH:Neuroprotection) |
| pubmed:19721446 | act(p(HGNC:CHRNA7)) decreases bp(MESH:Neuroprotection) |
| pubmed:27190210 | p(HGNC:CHRNA7) increases tloc(a(CHEBI:neurotransmitter), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27190210 | p(HGNC:CHRNA7) increases path(MESH:"Mental Processes") |
| pubmed:27190210 | act(p(HGNC:CHRNA7)) increases path(MESH:Attention) |
| pubmed:22530628 | p(HGNC:CHRNA7) increases path(MESH:Attention) |
| pubmed:22530628 | p(HGNC:CHRNA7) increases path(MESH:Attention) |
| pubmed:27190210 | p(HGNC:CHRNA7) increases path(MESH:Reward) |
| pubmed:27190210 | p(HGNC:CHRNA7) association bp(GO:"cell differentiation") |
| pubmed:27190210 | p(HGNC:CHRNA7) association bp(GO:"cell migration") |
| pubmed:27190210 | p(HGNC:CHRNA7) association bp(GO:"cell adhesion") |
| pubmed:27190210 | p(HGNC:CHRNA7) association bp(GO:angiogenesis) |
| pubmed:27190210 | p(HGNC:CHRNA7) regulates bp(GO:"receptor signaling pathway via JAK-STAT") |
| pubmed:27190210 | p(HGNC:CHRNA7) regulates bp(GO:"regulation of phosphatidylinositol 3-kinase signaling") |
| pubmed:27190210 | p(HGNC:CHRNA7) regulates bp(GO:"microglial cell activation") |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) decreases bp(GO:"microglial cell activation") |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) decreases bp(GO:"microglial cell activation") |
| pubmed:26979166 | p(HGNC:CHRNA7) decreases bp(GO:"microglial cell activation") |
| pubmed:26979166 | act(p(HGNC:CHRNA7, loc(MESH:Microglia))) increases bp(GO:"microglial cell activation") |
| pubmed:17009926 | p(HGNC:CHRNA7) increases bp(GO:"neurotransmitter secretion") |
| pubmed:29428175 | p(HGNC:CHRNA7) regulates bp(GO:"neurotransmitter secretion") |
| pubmed:22040696 | p(HGNC:CHRNA7) increases bp(GO:"neurotransmitter secretion") |
| pubmed:17009926 | p(HGNC:CHRNA7) increases act(complex(GO:"voltage-gated calcium channel complex")) |
| pubmed:17009926 | act(p(HGNC:CHRNA7)) increases bp(GO:"synaptic transmission, glutamatergic") |
| pubmed:17009926 | p(HGNC:CHRNA7) association a(CONSO:"amyloid-beta aggregates") |
| pubmed:17009926 | p(HGNC:CHRNA7) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:22530628 | p(HGNC:CHRNA7) association path(DOID:"Alzheimer's disease") |
| pubmed:22530628 | p(HGNC:CHRNA7) association path(DOID:schizophrenia) |
| pubmed:22530628 | p(HGNC:CHRNA7) association path(DOID:"Parkinson's disease") |
| pubmed:22530628 | p(HGNC:CHRNA7) association path(MESH:"Tobacco Use Disorder") |
| pubmed:22530628 | p(HGNC:CHRNA7) increases act(p(HGNC:AKT1)) |
| pubmed:22530628 | act(p(HGNC:CHRNA7)) increases act(p(HGNC:AKT1)) |
| pubmed:22530628 | p(HGNC:CHRNA7) increases p(HGNC:AKT1) |
| pubmed:29428175 | p(HGNC:CHRNA7) increases act(p(HGNC:AKT1), ma(GO:"GTPase activity")) |
| pubmed:22530628 | p(HGNC:CHRNA7) increases act(p(HGNC:GSK3B)) |
| pubmed:22530628 | p(HGNC:CHRNA7) increases bp(MESH:"Sensory Gating") |
| pubmed:19721446 | p(HGNC:CHRNA7) association bp(MESH:"Sensory Gating") |
| pubmed:22530628 | p(HGNC:CHRNA7) increases bp(MESH:"Cell Survival") |
| pubmed:28901280 | p(HGNC:CHRNA7) regulates bp(MESH:"Cell Survival") |
| pubmed:22530628 | p(HGNC:CHRNA7) increases p(HGNC:PIK3CA) |
| pubmed:22530628 | p(HGNC:CHRNA7) increases p(HGNC:MAPK3) |
| pubmed:22530628 | p(HGNC:CHRNA7) increases p(HGNC:MAPK1) |
| pubmed:22530628 | p(HGNC:CHRNA7) increases p(HGNC:CREBBP) |
| pubmed:22530628 | p(HGNC:CHRNA7) increases act(p(HGNC:PIK3R1)) |
| pubmed:22530628 | p(HGNC:CHRNA7) positiveCorrelation r(HGNC:ARC) |
| pubmed:22530628 | p(HGNC:CHRNA7) increases p(HGNC:ARC) |
| pubmed:26813123 | p(HGNC:CHRNA7) increases a(MESH:"Receptors, Nicotinic") |
| pubmed:29428175 | act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) increases tloc(a(CHEBI:"calcium ion"), fromLoc(GO:"endoplasmic reticulum"), toLoc(MESH:Cytoplasm)) |
| pubmed:29428175 | act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) increases tloc(a(CHEBI:"calcium ion"), fromLoc(GO:"endoplasmic reticulum"), toLoc(MESH:Cytoplasm)) |
| pubmed:29428175 | act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) regulates a(CHEBI:"calcium ion", loc(MESH:"Intracellular Space")) |
| pubmed:26979166 | p(HGNC:CHRNA7) regulates a(CHEBI:"calcium ion", loc(MESH:"Intracellular Space")) |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) increases tloc(a(CHEBI:"calcium ion"), fromLoc(GO:"pore complex"), toLoc(MESH:"Intracellular Space")) |
| pubmed:29428175 | act(p(HGNC:CHRNA7)) positiveCorrelation bp(GO:"glutamate secretion") |
| pubmed:29428175 | p(HGNC:CHRNA7) increases bp(MESH:"Calcium Signaling") |
| pubmed:29428175 | p(HGNC:CHRNA7) increases bp(MESH:"Calcium Signaling") |
| pubmed:29428175 | p(HGNC:CHRNA7) regulates bp(MESH:"Calcium Signaling") |
| pubmed:29428175 | act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) increases bp(MESH:"Calcium Signaling") |
| pubmed:29428175 | p(HGNC:CHRNA7) increases bp(MESH:"Calcium Signaling") |
| pubmed:29428175 | act(p(HGNC:CHRNA7)) regulates p(MESH:"Receptors, Glutamate", loc(GO:"postsynaptic membrane")) |
| pubmed:29428175 | act(p(HGNC:CHRNA7)) increases bp(GO:"sodium ion import across plasma membrane") |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) increases bp(GO:"sodium ion import across plasma membrane") |
| pubmed:29428175 | act(p(HGNC:CHRNA7)) increases bp(GO:"calcium ion import across plasma membrane") |
| pubmed:29428175 | act(p(HGNC:CHRNA7)) increases bp(GO:"calcium ion import across plasma membrane") |
| pubmed:29428175 | act(p(HGNC:CHRNA7)) increases bp(GO:"calcium ion import across plasma membrane") |
| pubmed:29428175 | act(p(HGNC:CHRNA7)) increases bp(GO:"membrane depolarization") |
| pubmed:30697142 | p(HGNC:CHRNA7) increases bp(GO:"membrane depolarization") |
| pubmed:29428175 | p(HGNC:CHRNA7) regulates bp(GO:"neuron projection development") |
| pubmed:29428175 | act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) regulates bp(GO:"hippocampus development") |
| pubmed:29428175 | act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) regulates bp(GO:"neuron maturation") |
| pubmed:29428175 | act(p(HGNC:CHRNA7)) increases bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") |
| pubmed:29428175 | p(HGNC:CHRNA7) increases bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") |
| pubmed:29428175 | p(HGNC:CHRNA7, loc(MESH:Synapses)) increases bp(GO:"positive regulation of cAMP-dependent protein kinase activity") |
| pubmed:29428175 | p(HGNC:CHRNA7, loc(MESH:Synapses)) increases p(HGNC:CAMK2B) |
| pubmed:29428175 | act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) increases act(p(HGNC:CAMK2B, loc(MESH:Synapses))) |
| pubmed:29428175 | p(HGNC:CHRNA7) increases act(p(HGNC:ADCY1)) |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) directlyIncreases act(p(HGNC:ADCY1)) |
| pubmed:29428175 | p(HGNC:CHRNA7) regulates bp(GO:"regulation of voltage-gated calcium channel activity") |
| pubmed:29428175 | p(HGNC:CHRNA7, loc(MESH:"Growth Cones")) increases bp(MESH:Growth) |
| pubmed:29428175 | p(HGNC:CHRNA7, loc(MESH:"Growth Cones")) increases a(GO:cytoskeleton) |
| pubmed:29428175 | p(HGNC:CHRNA7) increases act(p(HGNC:CDC42), ma(GO:"GTPase activity")) |
| pubmed:29428175 | p(HGNC:CHRNA7) regulates bp(MESH:"Cell Movement") |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) increases bp(GO:"calcium ion import") |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) decreases act(p(HGNC:TLR3)) |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) decreases act(p(HGNC:TLR4)) |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) decreases act(p(HGNC:TLR9)) |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) decreases act(p(HGNC:MAPK14)) |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) increases tloc(p(HGNC:HMGB1), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) decreases a(MESH:"Immune System") |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) regulates act(a(MESH:Microglia)) |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) decreases act(a(MESH:Macrophages)) |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) decreases tloc(a(MESH:Cytokines), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) increases composite(a(CHEBI:"calcium(2+)"), p(HGNC:ADCY1)) |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) decreases deg(a(MESH:"Gray Matter")) |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) decreases deg(a(MESH:"White Matter")) |
| pubmed:26979166 | p(HGNC:CHRNA7) decreases path(MESH:Depression) |
| pubmed:26979166 | p(HGNC:CHRNA7) decreases path(NCIT:C78349) |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) decreases bp(GO:"lymphocyte proliferation") |
| pubmed:26979166 | act(p(HGNC:CHRNA7)) decreases bp(GO:"macrophage activation") |
| pubmed:26979166 | p(HGNC:CHRNA7) decreases path(CONSO:neuroinflammation) |
| pubmed:26979166 | p(HGNC:CHRNA7) decreases deg(a(MESH:"Dopaminergic Neurons")) |
| pubmed:26979166 | act(p(HGNC:CHRNA7, loc(MESH:Microglia))) increases bp(GO:phagocytosis) |
| pubmed:26088141 | p(HGNC:CHRNA7) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ)) |
| pubmed:26088141 | p(HGNC:CHRNA7) increases bp(CONSO:"nAChR assembly") |
| pubmed:26088141 | p(HGNC:CHRNA7) increases p(HGNC:CHRNA7) |
| pubmed:26088141 | p(HGNC:CHRNA7) increases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7)) |
| pubmed:18986241 | p(HGNC:CHRNA7) increases complex(p(HGNC:APP), p(HGNC:CHRNA7)) |
| pubmed:19721446 | p(HGNC:CHRNA7) association a(MESH:Hippocampus) |
| pubmed:19721446 | p(HGNC:CHRNA7) association bp(GO:memory) |
| pubmed:19721446 | act(p(HGNC:CHRNA7)) decreases bp(GO:memory) |
| pubmed:19721446 | p(HGNC:CHRNA7) association bp(GO:learning) |
| pubmed:19721446 | p(HGNC:CHRNA7) association a(CHEBI:clozapine) |
| pubmed:22040696 | p(HGNC:CHRNA7) regulates bp(GO:"chemical synaptic transmission") |
| pubmed:22040696 | p(HGNC:CHRNA7) regulates bp(GO:"neuron-neuron synaptic transmission") |
| pubmed:22040696 | p(HGNC:CHRNA7) association path(MESH:"Neurodegenerative Diseases") |
| pubmed:22040696 | p(HGNC:CHRNA7) association p(HGNC:BDNF) |
| pubmed:22040696 | tloc(p(HGNC:CHRNA7), fromLoc(GO:"cell surface"), toLoc(GO:endosome)) increases act(p(HGNC:CREB1), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:22040696 | p(HGNC:CHRNA7) negativeCorrelation path(MESH:Schizophrenia) |
| pubmed:22040696 | p(HGNC:CHRNA7) decreases path(MESH:"Renal Insufficiency") |
| pubmed:22040696 | p(HGNC:CHRNA7) decreases bp(GO:"cytokine production") |
| pubmed:22040696 | p(HGNC:CHRNA7) decreases bp(GO:"apoptotic process") |
| pubmed:28901280 | p(HGNC:CHRNA7) association path(MESH:Neoplasms) |
| pubmed:28901280 | p(HGNC:CHRNA7) increases bp(GO:"intracellular receptor signaling pathway") |
| pubmed:28901280 | p(HGNC:CHRNA7) increases bp(GO:"JAK-STAT cascade") |
| pubmed:29191965 | p(HGNC:CHRNA7) regulates bp(GO:"musculoskeletal movement") |
| pubmed:29191965 | p(HGNC:CHRNA7) regulates act(a(GO:synapse)) |
| pubmed:29191965 | p(HGNC:CHRNA7) association path(MESH:Tauopathies) |
| pubmed:26813123 | p(HGNC:CHRNA9) increases a(MESH:"Receptors, Nicotinic") |
| pubmed:28901280 | p(HGNC:CHRNA9) increases path(MESH:Neoplasms) |
| pubmed:26813123 | p(HGNC:CHRNA10) increases a(MESH:"Receptors, Nicotinic") |
| pubmed:17009926 | act(p(HGNC:CHRNB2)) increases bp(GO:"depolarization of postsynaptic membrane") |
| pubmed:17009926 | p(HGNC:CHRNB2) increases bp(GO:"circadian sleep/wake cycle, wakefulness") |
| pubmed:26813123 | p(HGNC:CHRNB2) increases a(MESH:"Receptors, Nicotinic") |
| pubmed:19721446 | p(HGNC:CHRNB2) association p(HGNCGENEFAMILY:Tubulins) |
| pubmed:19721446 | p(HGNC:CHRNB2) association p(HGNC:DNM1) |
| pubmed:19721446 | p(HGNC:CHRNB2) association p(HGNCGENEFAMILY:"Clathrin subunits") |
| pubmed:19721446 | p(HGNC:CHRNB2) increases act(a(CHEBI:nicotine)) |
| pubmed:26813123 | p(HGNC:CHRNB3) increases a(MESH:"Receptors, Nicotinic") |
| pubmed:19126755 | p(HGNC:CHRNB4) association path(MESH:"Drug Tolerance") |
| pubmed:26813123 | p(HGNC:CHRNB4) increases a(MESH:"Receptors, Nicotinic") |
| pubmed:19721446 | p(HGNC:CHRNB4) decreases act(a(CHEBI:nicotine)) |
| pubmed:19721446 | p(HGNC:CHRNB4) association path(MESH:Craving) |
| pubmed:19721446 | p(HGNC:CHRNB4) association path(MESH:Recurrence) |
| pubmed:28901280 | p(HGNC:CHRNB4) positiveCorrelation bp(UBERON:0002138) |
| pubmed:19126755 | p(CONSO:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:Aging) |
| pubmed:19126755 | p(CONSO:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19126755 | p(CONSO:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19293145 | p(CONSO:"alpha-4 beta-2 nAChR") association path(MESH:"Alzheimer Disease") |
| pubmed:19126755 | act(p(CONSO:"alpha-4 beta-2 nAChR")) decreases act(a(MESH:Interneurons)) |
| pubmed:19126755 | act(p(CONSO:"alpha-4 beta-2 nAChR")) decreases bp(GO:"synaptic transmission, GABAergic") |
| pubmed:19126755 | act(p(CONSO:"alpha-4 beta-2 nAChR")) decreases act(complex(GO:"voltage-gated calcium channel complex")) |
| pubmed:19126755 | act(p(CONSO:"alpha-4 beta-2 nAChR", loc(MESH:"GABAergic Neurons"))) increases act(a(MESH:"Dopaminergic Neurons")) |
| pubmed:21482353 | p(CONSO:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"Dopaminergic Neurons") |
| pubmed:19126755 | p(CONSO:"alpha-4 beta-2 nAChR") positiveCorrelation bp(GO:cognition) |
| pubmed:21482353 | p(CONSO:"alpha-4 beta-2 nAChR") positiveCorrelation bp(GO:cognition) |
| pubmed:26472524 | act(p(CONSO:"alpha-4 beta-2 nAChR")) increases bp(GO:"depolarization of postsynaptic membrane") |
| pubmed:25514383 | p(CONSO:"alpha-4 beta-2 nAChR") negativeCorrelation bp(GO:"calcium ion transport") |
| pubmed:25514383 | act(p(CONSO:"alpha-4 beta-2 nAChR")) decreases bp(GO:"cellular calcium ion homeostasis") |
| pubmed:25514383 | act(p(CONSO:"alpha-4 beta-2 nAChR")) increases path(CONSO:"mitochondrial dysfunction") |
| pubmed:25514383 | act(p(CONSO:"alpha-4 beta-2 nAChR")) increases bp(GO:"response to oxidative stress") |
| pubmed:21482353 | p(CONSO:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"GABAergic Neurons") |
| pubmed:19126755 | p(CONSO:"alpha-6 alpha-4 beta-2 beta-3 nAChR", loc(MESH:"Basal Ganglia")) association path(MESH:"Parkinson Disease") |
| pubmed:19126755 | p(CONSO:"alpha-7-containing nAChR") increases bp(GO:"calcium ion transport into cytosol") |
| pubmed:26472524 | p(CONSO:"alpha-7-containing nAChR") increases act(p(HGNC:CHRNA7)) |
| pubmed:21482353 | p(CONSO:"alpha-7-containing nAChR") increases p(HGNC:SLC12A5) |
| pubmed:21482353 | p(CONSO:"alpha-7-containing nAChR") increases p(HGNC:SLC12A5) |
| pubmed:21482353 | p(CONSO:"alpha-7-containing nAChR") association bp(GO:"macrophage activation") |
| pubmed:21482353 | p(CONSO:"alpha-7-containing nAChR") association bp(GO:"response to cytokine") |
| pubmed:21787755 | p(CONSO:"alpha-7-containing nAChR") decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:21787755 | p(CONSO:"alpha-7-containing nAChR") regulates bp(GO:"excitatory chemical synaptic transmission") |
| pubmed:21787755 | p(CONSO:"alpha-7-containing nAChR") association bp(GO:"neurotransmitter secretion") |
| pubmed:21787755 | p(CONSO:"alpha-7-containing nAChR") association bp(GO:"maintenance of synapse structure") |
| pubmed:21787755 | p(CONSO:"alpha-7-containing nAChR") association bp(GO:"neuron projection maintenance") |
| pubmed:21787755 | p(CONSO:"alpha-7-containing nAChR") association bp(GO:"long-term synaptic potentiation") |
| pubmed:21787755 | p(CONSO:"alpha-7-containing nAChR") association path(MESH:Seizures) |
| pubmed:21787755 | p(CONSO:"alpha-7-containing nAChR") association bp(GO:"neuron death") |
| pubmed:19126755 | a(MESH:Manduca) association bp(GO:"establishment of blood-brain barrier") |
| pubmed:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", var("?")) decreases bp(GO:"response to nicotine") |
| pubmed:19126755 | a(TAXONOMY:8616) increases p(CONSO:alpha-Bungarotoxin) |
| pubmed:19126755 | complex(a(MESH:alpha-cobratoxin), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19126755 | complex(a(CONSO:kappa-Bungarotoxin), p(CONSO:"alpha-3 beta-4 nAChR")) decreases act(p(CONSO:"alpha-3 beta-4 nAChR")) |
| pubmed:19126755 | act(p(CONSO:"alpha-3 beta-4 nAChR")) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) |
| pubmed:19126755 | complex(a(CONSO:kappa-Bungarotoxin), p(HGNC:CHRNB4)) decreases act(p(HGNC:CHRNB4)) |
| pubmed:19126755 | a(MESH:Conotoxins) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19126755 | a(MESH:Conotoxins) decreases act(p(HGNCGENEFAMILY:"Potassium voltage-gated channels")) |
| pubmed:19126755 | a(MESH:Conotoxins) decreases act(p(MESH:"Voltage-Gated Sodium Channels")) |
| pubmed:19721446 | a(MESH:Conotoxins) association complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) |
| pubmed:19721446 | a(MESH:Conotoxins) decreases act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) |
| pubmed:19721446 | a(MESH:Conotoxins) decreases path(MESH:Pain) |
| pubmed:19126755 | p(HGNCGENEFAMILY:"Potassium voltage-gated channels") association a(CHEBI:anandamide) |
| pubmed:19126755 | a(TAXONOMY:1163) increases a(CHEBI:"Anatoxin a") |
| pubmed:19126755 | complex(a(CHEBI:"Anatoxin a"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19126755 | a(TAXONOMY:92736) increases a(CHEBI:epibatidine) |
| pubmed:19293145 | a(CHEBI:epibatidine) causesNoChange bp(GO:memory) |
| pubmed:19293145 | a(CHEBI:epibatidine) causesNoChange bp(GO:cognition) |
| pubmed:19293145 | a(CHEBI:epibatidine) causesNoChange path(MESH:"Plaque, Amyloid") |
| pubmed:19293145 | a(CHEBI:epibatidine) causesNoChange bp(MESH:"Neurofibrillary Tangles") |
| pubmed:28132910 | a(CHEBI:epibatidine) decreases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384)) |
| pubmed:19126755 | complex(a(CHEBI:epibatidine), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19126755 | complex(a(CHEBI:epibatidine), p(CONSO:"alpha-4 beta-2 nAChR")) increases act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:19126755 | complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7, loc(MESH:Muscles))) |
| pubmed:19293145 | a(MESH:methyllycaconitine) decreases act(p(HGNC:CHRNA7)) |
| pubmed:19293145 | a(MESH:methyllycaconitine) decreases act(p(HGNC:CHRNA7)) |
| pubmed:19293145 | a(MESH:methyllycaconitine) increases bp(MESH:Neuroprotection) |
| pubmed:25881725 | a(MESH:methyllycaconitine) decreases act(a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")) |
| pubmed:25881725 | a(MESH:methyllycaconitine) decreases act(a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")) |
| pubmed:25881725 | a(MESH:methyllycaconitine) decreases act(a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")) |
| pubmed:25881725 | a(MESH:methyllycaconitine) decreases act(a(CHEBI:galanthamine)) |
| pubmed:25881725 | a(MESH:methyllycaconitine) decreases act(a(CHEBI:galanthamine)) |
| pubmed:25881725 | a(MESH:methyllycaconitine) decreases act(a(CHEBI:galanthamine)) |
| pubmed:25881725 | a(MESH:methyllycaconitine) decreases act(p(MGI:Chrna7)) |
| pubmed:25881725 | a(MESH:methyllycaconitine) decreases act(p(MGI:Chrna7)) |
| pubmed:25881725 | a(MESH:methyllycaconitine) decreases p(MGI:Chrna7) |
| pubmed:25881725 | a(MESH:methyllycaconitine) decreases path(MESH:"Spatial Memory") |
| pubmed:25881725 | a(MESH:methyllycaconitine) causesNoChange r(MGI:Chrna7) |
| pubmed:19721446 | a(MESH:methyllycaconitine) decreases act(a(DRUGBANK:Facinicline)) |
| pubmed:19126755 | complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA6)) decreases act(p(HGNC:CHRNA6, loc(MESH:Muscles))) |
| pubmed:19126755 | complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA3)) decreases act(p(HGNC:CHRNA3, loc(MESH:Muscles))) |
| pubmed:19126755 | r(HGNC:CHRNA3) association p(HGNCGENEFAMILY:"ETS transcription factor family") |
| pubmed:27758088 | r(HGNC:CHRNA3) association a(MESH:Brain) |
| pubmed:27758088 | r(HGNC:CHRNA3) association r(HGNC:CHRNA5) |
| pubmed:27758088 | r(HGNC:CHRNA3) association r(MESH:"long non-coding RNA RP11-650L12.2, human") |
| pubmed:19126755 | r(HGNC:CHRNB4) association p(HGNCGENEFAMILY:"ETS transcription factor family") |
| pubmed:27758088 | r(HGNC:CHRNB4) association a(UBERON:0000010) |
| pubmed:21787755 | r(HGNC:CHRNB4) association r(HGNC:CHRNA4) |
| pubmed:21787755 | r(HGNC:CHRNA4) association r(HGNC:CHRNB4) |
| pubmed:27758088 | r(HGNC:CHRNA5) association a(MESH:Brain) |
| pubmed:27758088 | r(HGNC:CHRNA5) association r(HGNC:CHRNA3) |
| pubmed:27758088 | r(HGNC:CHRNA5) association r(MESH:"long non-coding RNA RP11-650L12.2, human") |
| pubmed:21787755 | r(HGNC:CHRNA6) association path(MESH:Reward) |
| pubmed:21787755 | r(HGNC:CHRNA6) association bp(MESH:"Drug Interactions") |
| pubmed:21787755 | r(HGNC:CHRNA6) association tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:19126755 | a(MESH:Fetus) increases r(HGNC:CHRNA3, loc(MESH:Brain)) |
| pubmed:19126755 | path(MESH:"Trauma, Nervous System") increases r(HGNC:CHRNA3, loc(MESH:Brain)) |
| pubmed:24561250 | path(MESH:"Trauma, Nervous System") increases path(MESH:"Alzheimer Disease") |
| pubmed:24561250 | path(MESH:"Trauma, Nervous System") increases complex(GO:"inflammasome complex") |
| pubmed:19126755 | a(MESH:Adult) decreases r(HGNC:CHRNA3, loc(MESH:Neurons)) |
| pubmed:19126755 | a(MESH:Adult) increases r(HGNC:CHRNA4, loc(MESH:Neurons)) |
| pubmed:19126755 | r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases bp(CONSO:"nAChR assembly") |
| pubmed:19126755 | act(complex(p(HGNC:JUN), p(HGNC:SP1)), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases r(HGNC:CHRNB4) |
| pubmed:18494933 | p(HGNC:JUN) partOf p(FPLX:AP1) |
| pubmed:19126755 | act(p(HGNC:SOX10)) increases r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19126755 | composite(p(HGNC:CHRNA7), p(HGNC:NGF)) increases r(HGNC:CHRNB4) |
| pubmed:19126755 | p(HGNCGENEFAMILY:"ETS transcription factor family") association r(HGNC:CHRNA3) |
| pubmed:19126755 | p(HGNCGENEFAMILY:"ETS transcription factor family") association r(HGNC:CHRNB4) |
| pubmed:19126755 | complex(p(HGNC:CHRNA5), p(HGNC:CHRNA7)) association p(HGNC:CHRNA7) |
| pubmed:19126755 | complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) association p(HGNC:CHRNA7) |
| pubmed:26979166 | complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) increases bp(GO:"pore complex assembly") |
| pubmed:26979166 | complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) increases tloc(p(MESH:"Cytochromes c"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:25514383 | complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) increases p(CONSO:"alpha-7 beta-2 nAChR") |
| pubmed:25514383 | complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) increases tloc(p(CONSO:"alpha-7 beta-2 nAChR"), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) |
| pubmed:19126755 | complex(p(HGNC:CHRNA7), p(HGNC:CHRNB3)) association p(HGNC:CHRNA7) |
| pubmed:19126755 | a(MESH:Muscles) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) |
| pubmed:19126755 | a(MESH:Muscles) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE), loc(MESH:"Neuromuscular Junction")) |
| pubmed:19126755 | a(MESH:Muscles) increases r(HGNC:CHRNA1) |
| pubmed:19126755 | a(MESH:Muscles) increases r(HGNC:CHRNB1) |
| pubmed:19126755 | a(MESH:Muscles) increases r(HGNC:CHRND) |
| pubmed:19126755 | a(MESH:Muscles) increases r(HGNC:CHRNG) |
| pubmed:19126755 | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) association a(MESH:Muscles) |
| pubmed:19126755 | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"cell surface")) |
| pubmed:23038257 | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) association a(CHEBI:chlorpromazine) |
| pubmed:26813123 | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) increases p(FPLX:CHRN) |
| pubmed:19126755 | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE), loc(MESH:"Neuromuscular Junction")) association a(MESH:Muscles) |
| pubmed:19126755 | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) decreases deg(complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))) |
| pubmed:19126755 | bp(GO:"depolarization of postsynaptic membrane") increases r(HGNC:CHRNE) |
| pubmed:19126755 | bp(GO:"depolarization of postsynaptic membrane") increases act(complex(GO:"voltage-gated calcium channel complex")) |
| pubmed:17009926 | bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"regulation of action potential firing rate") |
| pubmed:26472524 | bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"regulation of action potential firing rate") |
| pubmed:17009926 | bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"long-term synaptic potentiation") |
| pubmed:26472524 | bp(GO:"depolarization of postsynaptic membrane") decreases a(MESH:"Cations, Divalent") |
| pubmed:28901280 | bp(GO:"depolarization of postsynaptic membrane") association p(MESH:"Receptors, Nicotinic") |
| pubmed:19126755 | r(HGNC:CHRNE) decreases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) |
| pubmed:19126755 | r(HGNC:CHRNE) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) |
| pubmed:19126755 | composite(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG)) |
| pubmed:19126755 | complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) |
| pubmed:19126755 | complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) |
| pubmed:19126755 | composite(complex(p(HGNC:CHRNA1), p(HGNC:CHRND)), complex(p(HGNC:CHRNA1), p(HGNC:CHRNG))) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) |
| pubmed:19126755 | a(MESH:Oocytes) association complex(p(HGNC:CHRNA4), p(HGNC:CHRNA7), p(HGNC:CHRNB2)) |
| pubmed:19126755 | complex(p(HGNC:CHRNA4), p(HGNC:CHRNA7), p(HGNC:CHRNB2)) association a(MESH:Oocytes) |
| pubmed:19126755 | a(MESH:Ganglia) increases p(CONSO:"alpha-3 beta-4 nAChR") |
| pubmed:19126755 | a(MESH:Ganglia) increases p(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:19126755 | composite(a(MESH:"HEK293 Cells"), g(HGNC:CHRNA7)) increases r(HGNC:CHRNA7) |
| pubmed:19126755 | composite(a(MESH:"HEK293 Cells"), g(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7)) |
| pubmed:19126755 | g(HGNC:CHRNA7) increases p(HGNC:CHRNA7) |
| pubmed:19126755 | g(HGNC:CHRNA7) association path(MESH:"Sensory Gating") |
| pubmed:27190210 | g(HGNC:CHRNA7) association bp(GO:cognition) |
| pubmed:27190210 | g(HGNC:CHRNA7) association path(DOID:schizophrenia) |
| pubmed:27190210 | g(HGNC:CHRNA7) association path(MESH:"Intellectual Disability") |
| pubmed:27190210 | g(HGNC:CHRNA7) association path(DOID:"bipolar disorder") |
| pubmed:27190210 | g(HGNC:CHRNA7) association path(DOID:"autism spectrum disorder") |
| pubmed:27190210 | g(HGNC:CHRNA7) association path(DOID:"attention deficit hyperactivity disorder") |
| pubmed:27190210 | g(HGNC:CHRNA7) association path(DOID:epilepsy) |
| pubmed:27190210 | g(HGNC:CHRNA7) association path(DOID:"Alzheimer's disease") |
| pubmed:27190210 | g(HGNC:CHRNA7) negativeCorrelation bp(GO:"sensory processing") |
| pubmed:18986241 | r(HGNC:CHRNA7) negativeCorrelation path(MESH:Cognition) |
| pubmed:18986241 | r(HGNC:CHRNA7) regulates act(a(MESH:"Cholinergic Neurons")) |
| pubmed:18986241 | r(HGNC:CHRNA7) increases path(MESH:"Nerve Degeneration") |
| pubmed:11230871 | r(HGNC:CHRNA7) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19126755 | a(MESH:"Cell Line") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19126755 | a(MESH:"Cell Line") regulates complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| pubmed:19126755 | composite(g(HGNC:CHRNA4), g(HGNC:CHRNB2)) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| pubmed:25514383 | complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) increases p(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:19721446 | complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) association a(MESH:"Dopaminergic Neurons") |
| pubmed:21787755 | complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) association path(MESH:"Tobacco Use Disorder") |
| pubmed:21787755 | complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) association path(MESH:Reward) |
| pubmed:21787755 | complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) association path(MESH:"Alzheimer Disease") |
| pubmed:21787755 | complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) association path(MESH:Epilepsy) |
| pubmed:19126755 | p(HGNC:CHRNA7, frag("23_46")) increases complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7)) |
| pubmed:19126755 | p(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors") isA p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19126755 | a(MESH:"Endoplasmic Reticulum") regulates bp(CONSO:"nAChR assembly") |
| pubmed:19126755 | a(MESH:"Endoplasmic Reticulum") regulates p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19126755 | a(MESH:"Endoplasmic Reticulum") increases deg(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(GO:"endoplasmic reticulum"))) |
| pubmed:19126755 | bp(CONSO:"nAChR assembly") increases p(CONSO:"alpha-3 beta-4 nAChR", loc(GO:"cell surface")) |
| pubmed:19126755 | bp(CONSO:"nAChR assembly") increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"cell surface")) |
| pubmed:19126755 | a(CHEBI:"proteasome inhibitor") decreases deg(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(GO:"endoplasmic reticulum"))) |
| pubmed:19126755 | a(CHEBI:"proteasome inhibitor") increases bp(CONSO:"nAChR assembly") |
| pubmed:29626319 | a(CHEBI:"proteasome inhibitor") increases bp(GO:autophagy) |
| pubmed:29626319 | a(CHEBI:"proteasome inhibitor") decreases p(HGNC:MAPT) |
| pubmed:29626319 | a(CHEBI:"proteasome inhibitor") increases p(HGNC:BAG3) |
| pubmed:21787755 | p(CONSO:"alpha-3 beta-2 nAChR") regulates tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:19126755 | composite(a(CHEBI:nicotine), g(HGNC:CHRNA4)) increases p(HGNC:CHRNA4) |
| pubmed:19126755 | composite(a(CHEBI:nicotine), g(HGNC:CHRNA6)) increases p(HGNC:CHRNA6) |
| pubmed:19126755 | composite(a(CHEBI:nicotine), g(HGNC:CHRNB2)) increases p(HGNC:CHRNB2) |
| pubmed:19126755 | composite(a(CHEBI:nicotine), g(HGNC:CHRNB3)) increases p(HGNC:CHRNB3) |
| pubmed:30027901 | a(MESH:Interneurons) increases p(HGNC:SST) |
| pubmed:30027901 | a(MESH:Interneurons) increases p(HGNC:NPY) |
| pubmed:30027901 | a(MESH:Interneurons) increases p(HGNC:NQO1) |
| pubmed:19126755 | tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases bp(GO:"hyperpolarization of postsynaptic membrane") |
| pubmed:21482353 | a(CHEBI:"gamma-aminobutyric acid") increases act(p(HGNC:GABBR1)) |
| pubmed:21482353 | a(CHEBI:"gamma-aminobutyric acid") increases act(p(HGNC:GABBR2)) |
| pubmed:21482353 | a(CHEBI:"gamma-aminobutyric acid") decreases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pubmed:19126755 | bp(GO:"action potential initiation") decreases a(MESH:"Electric Stimulation", loc(GO:"Schaffer axon collateral")) |
| pubmed:19126755 | bp(GO:"action potential initiation") increases act(a(MESH:"Perforant Pathway")) |
| pubmed:26813123 | bp(GO:"action potential initiation") increases tloc(a(CHEBI:choline), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:26813123 | bp(GO:"action potential initiation") increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) |
| pubmed:26813123 | bp(GO:"action potential initiation") increases a(CHEBI:acetylcholine) |
| pubmed:26813123 | bp(GO:"action potential initiation") increases a(CHEBI:acetylcholine) |
| pubmed:26813123 | bp(GO:"action potential initiation") association complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) |
| pubmed:28901280 | bp(GO:"action potential initiation") association p(MESH:"Receptors, Nicotinic") |
| pubmed:19126755 | act(complex(GO:"voltage-gated calcium channel complex")) increases bp(GO:"calcineurin-mediated signaling") |
| pubmed:19126755 | act(complex(GO:"voltage-gated calcium channel complex")) decreases act(p(FPLX:CREB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:19126755 | complex(GO:"voltage-gated calcium channel complex") association a(CHEBI:anandamide) |
| pubmed:29428175 | complex(GO:"voltage-gated calcium channel complex") increases a(CHEBI:"calcium(2+)", loc(MESH:Cytoplasm)) |
| pubmed:19126755 | p(CONSO:"alpha-4-containing nAChR") increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:19126755 | p(CONSO:"alpha-4-containing nAChR") association path(MESH:"Drug Tolerance") |
| pubmed:19126755 | p(CONSO:"alpha-6-containing nAChR") increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21787755 | p(CONSO:"alpha-6-containing nAChR") association path(MESH:Pleasure) |
| pubmed:21787755 | p(CONSO:"alpha-6-containing nAChR") association path(MESH:Reward) |
| pubmed:21787755 | p(CONSO:"alpha-6-containing nAChR") association path(MESH:Affect) |
| pubmed:21787755 | p(CONSO:"alpha-6-containing nAChR") regulates tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21787755 | p(CONSO:"alpha-6-containing nAChR") association path(MESH:"Tobacco Use Disorder") |
| pubmed:21787755 | p(CONSO:"alpha-6-containing nAChR") regulates bp(GO:"neurotransmitter secretion") |
| pubmed:19126755 | bp(GO:"neuronal action potential") increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28445721 | bp(GO:"neuronal action potential") regulates p(FPLX:CHRN) |
| pubmed:19126755 | a(MESH:Neuroglia) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19126755 | a(MESH:Keratinocytes) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:28901280 | a(MESH:Keratinocytes) increases complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) |
| pubmed:28901280 | a(MESH:Keratinocytes) increases p(HGNC:CHRNA9) |
| pubmed:19126755 | a(MESH:"Cholinesterase Inhibitors") causesNoChange act(p(HGNC:CHRNA7)) |
| pubmed:19293145 | act(a(MESH:"Cholinesterase Inhibitors")) decreases act(a(CHEBI:amyloid-beta)) |
| pubmed:18986241 | a(MESH:"Cholinesterase Inhibitors") decreases a(CHEBI:amyloid-beta) |
| pubmed:19293145 | act(a(MESH:"Cholinesterase Inhibitors")) decreases act(a(CHEBI:"L-glutamate(2-)")) |
| pubmed:26813123 | a(MESH:"Cholinesterase Inhibitors") increases a(CHEBI:acetylcholine) |
| pubmed:26813123 | a(MESH:"Cholinesterase Inhibitors") increases bp(GO:cognition) |
| pubmed:18986241 | a(MESH:"Cholinesterase Inhibitors") decreases path(MESH:"Alzheimer Disease") |
| pubmed:18986241 | a(MESH:"Cholinesterase Inhibitors") increases bp(MESH:Neuroprotection) |
| pubmed:18986241 | a(MESH:"Cholinesterase Inhibitors") association bp(GO:"amyloid-beta metabolic process") |
| pubmed:18986241 | a(MESH:"Cholinesterase Inhibitors") association path(MESH:"Sleep Initiation and Maintenance Disorders") |
| pubmed:18986241 | a(MESH:"Cholinesterase Inhibitors") association path(MESH:Diarrhea) |
| pubmed:18986241 | a(MESH:"Cholinesterase Inhibitors") association path(MESH:Nausea) |
| pubmed:18986241 | a(MESH:"Cholinesterase Inhibitors") association path(MESH:Fatigue) |
| pubmed:18986241 | a(MESH:"Cholinesterase Inhibitors") association path(MESH:Anorexia) |
| pubmed:19126755 | a(CHEBI:physostigmine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19126755 | a(CHEBI:physostigmine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(MESH:"Neuromuscular Junction"))) |
| pubmed:19126755 | a(CHEBI:physostigmine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:18986241 | a(CHEBI:physostigmine) decreases path(MESH:"Alzheimer Disease") |
| pubmed:19126755 | a(CHEBI:"nicotinic antagonist") causesNoChange act(a(CHEBI:galanthamine)) |
| pubmed:19126755 | a(CHEBI:"nicotinic antagonist") causesNoChange act(a(CHEBI:physostigmine)) |
| pubmed:19126755 | a(CHEBI:"nicotinic antagonist") causesNoChange a(CHEBI:codeine) |
| pubmed:17009926 | a(CHEBI:"nicotinic antagonist") decreases tloc(a(CHEBI:acetylcholine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17009926 | a(CHEBI:"nicotinic antagonist") decreases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17009926 | a(CHEBI:"nicotinic antagonist") decreases tloc(a(CHEBI:noradrenaline), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17009926 | a(CHEBI:"nicotinic antagonist") decreases tloc(a(CHEBI:serotonin), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17009926 | a(CHEBI:"nicotinic antagonist") decreases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17009926 | a(CHEBI:"nicotinic antagonist") decreases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17009926 | a(CHEBI:"nicotinic antagonist") decreases bp(GO:memory) |
| pubmed:19126755 | a(CONSO:"FK1 antibody") decreases act(a(CHEBI:galanthamine)) |
| pubmed:19126755 | a(CONSO:"FK1 antibody") decreases act(a(CHEBI:physostigmine)) |
| pubmed:19126755 | a(CONSO:"FK1 antibody") decreases a(CHEBI:codeine) |
| pubmed:19126755 | a(CHEBI:codeine) causesNoChange a(MESH:Cholinesterases) |
| pubmed:19126755 | a(CHEBI:codeine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19126755 | path(MESH:"Sensory Gating") association g(HGNC:CHRNA7) |
| pubmed:19126755 | path(MESH:"Sensory Gating") association path(MESH:Schizophrenia) |
| pubmed:19126755 | path(MESH:"Sensory Gating") association path(MESH:Schizophrenia) |
| pubmed:19126755 | path(MESH:"Sensory Gating") association act(p(HGNC:CHRNA7)) |
| pubmed:19126755 | a(CHEBI:"kynurenic acid") negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19126755 | a(CHEBI:"kynurenic acid") decreases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pubmed:19126755 | a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7)) |
| pubmed:19126755 | a(CHEBI:"kynurenic acid") regulates act(p(HGNC:CHRNA7)) |
| pubmed:19126755 | a(CHEBI:"kynurenic acid") regulates act(p(HGNC:CHRNA7)) |
| pubmed:19126755 | a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7)) |
| pubmed:19126755 | a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7)) |
| pubmed:19126755 | a(CHEBI:"kynurenic acid") decreases act(p(MGI:Chrna7, loc(MESH:Interneurons))) |
| pubmed:19126755 | a(CHEBI:"kynurenic acid") regulates bp(MESH:"Neuronal Plasticity") |
| pubmed:19126755 | a(CHEBI:"kynurenic acid") regulates bp(GO:"synaptic transmission, cholinergic") |
| pubmed:19126755 | a(CHEBI:"kynurenic acid") regulates path(MESH:"Cell Survival") |
| pubmed:19126755 | a(CHEBI:"kynurenic acid") decreases a(CHEBI:dopamine, loc(GO:"extracellular region")) |
| pubmed:19126755 | a(CHEBI:L-kynurenine) increases a(CHEBI:"kynurenic acid") |
| pubmed:19126755 | a(MESH:Probenecid) decreases a(CHEBI:"kynurenic acid") |
| pubmed:19126755 | act(p(HGNC:AADAT), ma(go:0003824 ! "catalytic activity")) increases a(CHEBI:"kynurenic acid") |
| pubmed:19126755 | a(CHEBI:kynurenine) increases a(CHEBI:"kynurenic acid") |
| pubmed:19126755 | a(CHEBI:kynurenine) increases a(CHEBI:3-hydroxykynurenine) |
| pubmed:19126755 | a(CHEBI:kynurenine) increases a(CHEBI:"quinolinic acid") |
| pubmed:19165623 | a(CHEBI:"quinolinic acid") increases a(CHEBI:"nicotinic acid") |
| pubmed:19623258 | a(CHEBI:"quinolinic acid") association p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:19623258 | a(CHEBI:"quinolinic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:19623258 | a(CHEBI:"quinolinic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:19623258 | a(CHEBI:"quinolinic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:19623258 | a(CHEBI:"quinolinic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:19623258 | a(CHEBI:"quinolinic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:19623258 | a(CHEBI:"quinolinic acid") decreases act(p(FPLX:PPP2)) |
| pubmed:19623258 | a(CHEBI:"quinolinic acid") decreases act(p(FPLX:PPP1)) |
| pubmed:19623258 | a(CHEBI:"quinolinic acid") increases act(complex(GO:"NMDA selective glutamate receptor complex")) |
| pubmed:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:BRCA1) |
| pubmed:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:MYC) |
| pubmed:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:WNT1) |
| pubmed:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:CCN4) |
| pubmed:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:CDK5) |
| pubmed:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:IL1A) |
| pubmed:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:NOS2) |
| pubmed:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:CEBPB) |
| pubmed:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:CSF2) |
| pubmed:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:LEP) |
| pubmed:19126755 | act(p(MGI:Chrna7, loc(MESH:Interneurons))) increases act(a(MESH:"GABAergic Neurons")) |
| pubmed:19126755 | p(MGI:Chrna7) negativeCorrelation path(MESH:Aging) |
| pubmed:19293145 | p(MGI:Chrna7) increases bp(MESH:"Neuronal Outgrowth") |
| pubmed:25514383 | p(MGI:Chrna7) decreases path(MESH:"Spatial Memory") |
| pubmed:25881725 | act(p(MGI:Chrna7)) increases path(MESH:"Spatial Memory") |
| pubmed:25514383 | p(MGI:Chrna7) decreases p(MGI:Syp) |
| pubmed:25514383 | p(MGI:Chrna7) decreases p(MGI:Map2) |
| pubmed:25514383 | p(MGI:Chrna7) increases p(MGI:Map2) |
| pubmed:25514383 | p(MGI:Chrna7) increases a(CHEBI:amyloid-beta) |
| pubmed:25514383 | p(MGI:Chrna7) decreases a(CHEBI:amyloid-beta) |
| pubmed:25514383 | p(MGI:Chrna7) increases bp(GO:cognition) |
| pubmed:25514383 | p(MGI:Chrna7) decreases path(MESH:"Cognition Disorders") |
| pubmed:25514383 | p(MGI:Chrna7) increases path(MESH:"Plaque, Amyloid") |
| pubmed:27522251 | p(MGI:Chrna7) decreases path(MESH:"Memory Disorders") |
| pubmed:27522251 | p(MGI:Chrna7) decreases path(MESH:"Memory Disorders") |
| pubmed:27522251 | p(MGI:Chrna7) decreases path(MESH:"Cognitive Dysfunction") |
| pubmed:27522251 | p(MGI:Chrna7) association bp(GO:aging) |
| pubmed:27522251 | p(MGI:Chrna7) increases a(CONSO:CONSO00022) |
| pubmed:25881725 | act(p(MGI:Chrna7)) increases bp(GO:learning) |
| pubmed:25881725 | p(MGI:Chrna7) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:28901280 | p(MGI:Chrna7) association act(a(MESH:Epithelium)) |
| pubmed:21482353 | a(MESH:"GABAergic Neurons") positiveCorrelation p(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:18986241 | a(MESH:"GABAergic Neurons") association path(MESH:"Cholinergic Neurons") |
| pubmed:30027901 | a(MESH:"GABAergic Neurons") increases p(HGNC:GAD1) |
| pubmed:30027901 | a(MESH:"GABAergic Neurons") increases p(HGNC:TAC1) |
| pubmed:30027901 | a(MESH:"GABAergic Neurons") increases p(MESH:Enkephalins) |
| pubmed:30027901 | a(MESH:"GABAergic Neurons") increases a(CHEBI:calcineurin) |
| pubmed:30027901 | a(MESH:"GABAergic Neurons") increases p(HGNC:CALB1) |
| pubmed:30027901 | a(MESH:"GABAergic Neurons") increases a(CHEBI:"Adenosine 5'-phosphate disodium") |
| pubmed:30027901 | a(MESH:"GABAergic Neurons") increases p(HGNCGENEFAMILY:"Dopamine receptors") |
| pubmed:30027901 | deg(a(MESH:"GABAergic Neurons")) prognosticBiomarkerFor path(MESH:"Huntington Disease") |
| pubmed:19126755 | a(MESH:"Mossy Fibers, Hippocampal") increases a(CHEBI:"glutamate(2-)", loc(MESH:"Pyramidal Cells")) |
| pubmed:19126755 | a(MESH:"7-chlorothiokynurenic acid") causesNoChange a(CHEBI:dopamine, loc(GO:"extracellular region")) |
| pubmed:28901280 | a(MESH:Acetylcholine) association bp(GO:"cell-cell signaling") |
| pubmed:28901280 | a(MESH:Acetylcholine) association bp(GO:"cell proliferation") |
| pubmed:28901280 | a(MESH:Acetylcholine) association bp(GO:"cell adhesion") |
| pubmed:28901280 | a(MESH:Acetylcholine) association bp(MESH:"Cell Movement") |
| pubmed:28901280 | a(MESH:Acetylcholine) association bp(GO:"secretion by cell") |
| pubmed:28901280 | a(MESH:Acetylcholine) association bp(MESH:"Cell Survival") |
| pubmed:28901280 | a(MESH:Acetylcholine) association bp(MESH:Apoptosis) |
| pubmed:28901280 | a(MESH:Acetylcholine) association bp(MESH:"Autocrine Communication") |
| pubmed:28901280 | a(MESH:Acetylcholine) association bp(MESH:"Paracrine Communication") |
| pubmed:28901280 | a(MESH:Acetylcholine) decreases path(MESH:Inflammation) |
| pubmed:28901280 | a(MESH:Acetylcholine) increases path(MESH:Neoplasms) |
| pubmed:28901280 | a(MESH:Acetylcholine) increases act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) |
| pubmed:28901280 | a(MESH:Acetylcholine) increases act(p(HGNC:CHRNA9)) |
| pubmed:19126755 | a(CHEBI:anandamide) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19126755 | a(CHEBI:anandamide) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19126755 | a(CHEBI:anandamide) association p(HGNC:CNR1) |
| pubmed:19126755 | a(CHEBI:anandamide) association p(HGNC:CNR2) |
| pubmed:19126755 | a(CHEBI:anandamide) association complex(GO:"voltage-gated calcium channel complex") |
| pubmed:19126755 | a(CHEBI:anandamide) association p(HGNCGENEFAMILY:"Potassium voltage-gated channels") |
| pubmed:19126755 | a(CHEBI:anandamide) association a(MESH:"Receptors, Serotonin") |
| pubmed:19126755 | a(CHEBI:anandamide) association p(HGNCGENEFAMILY:"Glutamate ionotropic receptor kainate type subunits") |
| pubmed:19126755 | a(CHEBI:anandamide) decreases act(p(HGNC:CHRNA7)) |
| pubmed:19126755 | a(CHEBI:anandamide) decreases act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:19126755 | a(CHEBI:anandamide) regulates bp(GO:"chemical synaptic transmission, postsynaptic") |
| pubmed:19126755 | p(CONSO:gamma-secretase) increases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:19293145 | complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) decreases act(a(MESH:Bungarotoxins)) |
| pubmed:17009926 | complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) association path(MESH:"Alzheimer Disease") |
| pubmed:25514383 | complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) association path(MESH:"Plaque, Amyloid") |
| pubmed:19126755 | p(HGNC:CNR2) association a(CHEBI:anandamide) |
| pubmed:19126755 | a(MESH:"Receptors, Serotonin") association a(CHEBI:anandamide) |
| pubmed:19126755 | a(CHEBI:bupropion) decreases act(p(HGNC:CHRNA7)) |
| pubmed:19126755 | a(CHEBI:bupropion) decreases act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:19126755 | a(CHEBI:bupropion) decreases act(p(CONSO:"alpha-3 beta-4 nAChR")) |
| pubmed:19126755 | a(CHEBI:bupropion) association path(MESH:"Smoking Cessation") |
| pubmed:28391535 | a(CHEBI:bupropion) association path(MESH:"Smoking Cessation") |
| pubmed:28391535 | a(CHEBI:bupropion) increases act(a(MESH:"Central Nervous System")) |
| pubmed:28391535 | a(CHEBI:bupropion) decreases path(MESH:Depression) |
| pubmed:28391535 | a(CHEBI:bupropion) decreases act(a(CHEBI:nicotine)) |
| pubmed:19126755 | a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(HGNC:CHRNA7)) |
| pubmed:19126755 | a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:19126755 | a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(CONSO:"alpha-3 beta-4 nAChR")) |
| pubmed:19126755 | path(MESH:"Smoking Cessation") association a(CHEBI:bupropion) |
| pubmed:28391535 | path(MESH:"Smoking Cessation") association a(CHEBI:bupropion) |
| pubmed:28391535 | path(MESH:"Smoking Cessation") increases path(MESH:"Irritable Mood") |
| pubmed:28391535 | path(MESH:"Smoking Cessation") increases path(MESH:Anger) |
| pubmed:28391535 | path(MESH:"Smoking Cessation") increases path(MESH:"Stress, Psychological") |
| pubmed:28391535 | path(MESH:"Smoking Cessation") increases path(MESH:Anxiety) |
| pubmed:28391535 | path(MESH:"Smoking Cessation") increases path(MESH:"Sleep Wake Disorders") |
| pubmed:28391535 | path(MESH:"Smoking Cessation") increases path(MESH:Depression) |
| pubmed:28391535 | path(MESH:"Smoking Cessation") increases path(MESH:Craving) |
| pubmed:28391535 | path(MESH:"Smoking Cessation") decreases bp(GO:cognition) |
| pubmed:28391535 | path(MESH:"Smoking Cessation") decreases path(MESH:Attention) |
| pubmed:28391535 | path(MESH:"Smoking Cessation") increases path(MESH:Appetite) |
| pubmed:28391535 | path(MESH:"Smoking Cessation") association a(CHEBI:varenicline) |
| pubmed:19721446 | act(p(FPLX:"CAMK2_complex")) increases act(a(CHEBI:nicotine)) |
| pubmed:23001711 | p(FPLX:"CAMK2_complex") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:19126755 | path(MESH:"Tobacco Use Disorder") association act(p(HGNC:MAPK1)) |
| pubmed:19126755 | path(MESH:"Tobacco Use Disorder") association act(p(FPLX:CREB)) |
| pubmed:19126755 | path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Wound Healing") |
| pubmed:19126755 | path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Wound Healing") |
| pubmed:19126755 | path(MESH:"Tobacco Use Disorder") association path(MESH:Infection) |
| pubmed:19126755 | path(MESH:"Tobacco Use Disorder") association path(MESH:"Skin Aging") |
| pubmed:19126755 | path(MESH:"Tobacco Use Disorder") increases path(MESH:"Skin Aging") |
| pubmed:19126755 | path(MESH:"Tobacco Use Disorder") association path(MESH:Neoplasms) |
| pubmed:19126755 | path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Colitis, Ulcerative") |
| pubmed:19126755 | path(MESH:"Tobacco Use Disorder") increases path(MESH:"Crohn Disease") |
| pubmed:19126755 | path(MESH:"Tobacco Use Disorder") association path(MESH:"Insulin Resistance") |
| pubmed:19126755 | path(MESH:"Tobacco Use Disorder") negativeCorrelation path(MESH:"Parkinson Disease") |
| pubmed:22530628 | path(MESH:"Tobacco Use Disorder") association p(HGNC:CHRNA7) |
| pubmed:29428175 | path(MESH:"Tobacco Use Disorder") positiveCorrelation g(HGNC:RHOA, var("?")) |
| pubmed:28445721 | path(MESH:"Tobacco Use Disorder") association p(FPLX:CHRN) |
| pubmed:21482353 | path(MESH:"Tobacco Use Disorder") association act(p(FPLX:CHRN)) |
| pubmed:21482353 | path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA5, var("?")) |
| pubmed:21482353 | path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA5, var("?")) |
| pubmed:21482353 | path(MESH:"Tobacco Use Disorder") positiveCorrelation path(MESH:Schizophrenia) |
| pubmed:21482353 | path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA3, var("?")) |
| pubmed:21482353 | path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNB4, var("?")) |
| pubmed:21482353 | path(MESH:"Tobacco Use Disorder") increases act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:21787755 | path(MESH:"Tobacco Use Disorder") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| pubmed:21787755 | path(MESH:"Tobacco Use Disorder") association composite(r(HGNC:CHRNA4), r(HGNC:CHRNB4)) |
| pubmed:21787755 | path(MESH:"Tobacco Use Disorder") association p(CONSO:"alpha-6-containing nAChR") |
| pubmed:28901280 | path(MESH:"Tobacco Use Disorder") association g(DBSNP:rs1051730) |
| pubmed:19126755 | a(MESH:Skin) association act(a(CHEBI:nicotine)) |
| pubmed:29626319 | a(MESH:Skin) decreases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | a(MESH:Skin) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pubmed:29626319 | a(MESH:Skin) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:19126755 | path(MESH:"Skin Aging") association path(MESH:"Tobacco Use Disorder") |
| pubmed:22807490 | path(MESH:"Colitis, Ulcerative") association path(MESH:Smoking) |
| pubmed:23746257 | bp(GO:"cell cycle") association p(FPLX:HSP90) |
| pubmed:30126037 | bp(GO:"cell cycle") association bp(GO:"cellular senescence") |
| pubmed:27190210 | bp(MESH:Apoptosis) association p(HGNC:CHRNA7) |
| pubmed:28901280 | bp(MESH:Apoptosis) association a(MESH:Acetylcholine) |
| pubmed:21722302 | bp(MESH:Apoptosis) association p(HGNC:BAX) |
| pubmed:21722302 | bp(MESH:Apoptosis) association p(HGNC:BAK1) |
| pubmed:19126755 | path(MESH:"Insulin Resistance") association path(MESH:"Tobacco Use Disorder") |
| pubmed:19126755 | path(MESH:"Insulin Resistance") increases path(MESH:"Diabetes Mellitus, Type 1") |
| pubmed:21718217 | path(MESH:"Insulin Resistance") association p(HGNC:PPARGC1A) |
| pubmed:19126755 | path(MESH:"Genetic Variation") association act(a(CHEBI:nicotine)) |
| pubmed:19126755 | a(MESH:"Mice, Inbred Strains") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19126755 | a(MESH:"Mice, Inbred Strains") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19126755 | a(MESH:"Rats, Inbred Strains") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19126755 | path(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24511233 | path(MESH:"Neurofibrillary Tangles") biomarkerFor path(MESH:"Alzheimer Disease") |
| pubmed:24590577 | path(MESH:"Neurofibrillary Tangles") association path(MESH:"Alzheimer Disease") |
| pubmed:24027553 | path(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24590577 | path(MESH:"Neurofibrillary Tangles") association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:24027553 | path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24027553 | path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:24027553 | path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(CONSO:nitration)) |
| pubmed:24027553 | path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, frag("1_?")) |
| pubmed:24027553 | path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, frag("?_*")) |
| pubmed:24027553 | path(MESH:"Neurofibrillary Tangles") association a(CHEBI:Thrombin) |
| pubmed:24027553 | path(MESH:"Neurofibrillary Tangles") association p(HGNC:CAPN2) |
| pubmed:24027553 | path(MESH:"Neurofibrillary Tangles") positiveCorrelation act(p(HGNCGENEFAMILY:Caspases)) |
| pubmed:24027553 | path(MESH:"Neurofibrillary Tangles") association act(p(HGNCGENEFAMILY:Caspases)) |
| pubmed:24027553 | path(MESH:"Neurofibrillary Tangles") association p(CONSO:"Tau C3") |
| pubmed:24027553 | path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:19126755 | path(MESH:"Neurogenic Inflammation") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:30837838 | path(MESH:"Neurogenic Inflammation") increases bp(GO:"mast cell degranulation") |
| pubmed:19126755 | p(MGI:Chrnb2) negativeCorrelation path(CONSO:Neurodegeneration) |
| pubmed:25514383 | p(MGI:Chrnb2) regulates bp(MESH:Homeostasis) |
| pubmed:25514383 | p(MGI:Chrnb2) increases a(MESH:"Cerebral Cortex") |
| pubmed:25514383 | p(MGI:Chrnb2) increases path(MESH:Attention) |
| pubmed:25514383 | p(MGI:Chrnb2) increases bp(GO:cognition) |
| pubmed:27522251 | p(MGI:Chrnb2) decreases path(MESH:"Memory Disorders") |
| pubmed:27522251 | p(MGI:Chrnb2) increases a(CHEBI:amyloid-beta) |
| pubmed:19126755 | p(MGI:Chrna4) negativeCorrelation path(MESH:Aging) |
| pubmed:19126755 | act(p(HGNC:PTGS1)) increases a(CHEBI:"prostaglandin H2") |
| pubmed:19126755 | a(CHEBI:NS-398) increases p(HGNC:CHRNA4) |
| pubmed:19126755 | path(MESH:Tremor) positiveCorrelation path(MESH:"Parkinson Disease") |
| pubmed:19126755 | path(MESH:Hypokinesia) positiveCorrelation path(MESH:"Parkinson Disease") |
| pubmed:19126755 | path(MESH:"Muscle Rigidity") positiveCorrelation path(MESH:"Parkinson Disease") |
| pubmed:21722302 | path(MESH:"Muscle Rigidity") prognosticBiomarkerFor path(MESH:"Parkinson Disease") |
| pubmed:17009926 | path(MESH:"Behavior, Addictive") association p(FPLX:CHRN) |
| pubmed:29428175 | path(MESH:"Behavior, Addictive") association complex(complex(GO:"heterotrimeric G-protein complex"), p(HGNC:CHRNA7)) |
| pubmed:19721446 | path(MESH:Craving) association p(HGNC:CHRNA3) |
| pubmed:19721446 | path(MESH:Craving) association p(HGNC:CHRNB4) |
| pubmed:19126755 | p(CONSO:"beta-2-containing nAChR") association a(CHEBI:nicotine) |
| pubmed:19126755 | p(CONSO:"beta-2-containing nAChR") causesNoChange act(a(CHEBI:nicotine)) |
| pubmed:19126755 | path(MESH:"Drug Tolerance") association p(HGNC:CHRNB4) |
| pubmed:19126755 | path(MESH:"Drug Tolerance") association p(CONSO:"alpha-4-containing nAChR") |
| pubmed:27758088 | a(UBERON:0000010) association r(HGNC:CHRNB4) |
| pubmed:27758088 | r(MESH:"long non-coding RNA RP11-650L12.2, human") association r(HGNC:CHRNA3) |
| pubmed:27758088 | r(MESH:"long non-coding RNA RP11-650L12.2, human") association r(HGNC:CHRNA5) |
| pubmed:27758088 | g(DBSNP:rs880395) increases r(HGNC:CHRNA5) |
| pubmed:27758088 | g(DBSNP:rs880395) increases r(HGNC:CHRNA5) |
| pubmed:27758088 | g(DBSNP:rs880395) increases r(HGNC:CHRNA5) |
| pubmed:27758088 | g(DBSNP:rs880395) increases r(MESH:"long non-coding RNA RP11-650L12.2, human") |
| pubmed:27758088 | g(DBSNP:rs880395) increases r(MESH:"long non-coding RNA RP11-650L12.2, human") |
| pubmed:27758088 | g(DBSNP:rs880395) increases r(HGNC:CHRNA3) |
| pubmed:27758088 | g(DBSNP:rs880395) causesNoChange r(HGNC:CHRNA3) |
| pubmed:27758088 | g(DBSNP:rs880395) increases r(HGNC:CHRNA3) |
| pubmed:27758088 | g(DBSNP:rs880395) decreases p(HGNC:PSMA4) |
| pubmed:27758088 | g(DBSNP:rs880395) decreases path(MESH:"Tobacco Use Disorder") |
| pubmed:27758088 | g(DBSNP:rs1948) increases r(HGNC:CHRNA3) |
| pubmed:27758088 | g(DBSNP:rs1948) increases r(HGNC:CHRNA3) |
| pubmed:27758088 | g(DBSNP:rs1948) increases r(HGNC:CHRNA3) |
| pubmed:27758088 | g(DBSNP:rs1948) increases r(MESH:"long non-coding RNA RP11-650L12.2, human") |
| pubmed:27758088 | g(DBSNP:rs1948) increases path(MESH:"Tobacco Use Disorder") |
| pubmed:27758088 | g(DBSNP:rs16969968) increases path(MESH:"Tobacco Use Disorder") |
| pubmed:27758088 | g(DBSNP:rs16969968) increases path(MESH:"Tobacco Use Disorder") |
| pubmed:28901280 | g(DBSNP:rs16969968) association act(a(MESH:Nicotine)) |
| pubmed:27758088 | composite(g(DBSNP:rs880395), r(HGNC:CHRNA5)) decreases path(MESH:"Tobacco Use Disorder") |
| pubmed:27758088 | composite(g(DBSNP:rs1948), r(HGNC:CHRNA3)) increases path(MESH:"Tobacco Use Disorder") |
| pubmed:18986241 | path(MESH:"Psychomotor Performance") positiveCorrelation a(MESH:"Frontal Lobe") |
| pubmed:19293145 | path(MESH:Death) association path(MESH:"Alzheimer Disease") |
| pubmed:19293145 | a(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:18986241 | a(MESH:"Neurofibrillary Tangles") association path(MESH:"Alzheimer Disease") |
| pubmed:19293145 | a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT) |
| pubmed:14556719 | a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT) |
| pubmed:14556719 | a(MESH:"Neurofibrillary Tangles") increases p(HGNC:MAPT) |
| pubmed:27574109 | a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT) |
| pubmed:18986241 | a(MESH:"Neurofibrillary Tangles") association path(MESH:"Cholinergic Neurons") |
| pubmed:18986241 | a(MESH:"Neurofibrillary Tangles") association p(HGNC:BCHE) |
| pubmed:18986241 | a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:21722302 | a(MESH:"Neurofibrillary Tangles") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:21722302 | a(MESH:"Neurofibrillary Tangles") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:14556719 | a(MESH:"Neurofibrillary Tangles") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:26195256 | a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:22299660 | a(MESH:"Neurofibrillary Tangles") association p(FPLX:PPP2C, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:14556719 | a(MESH:"Neurofibrillary Tangles") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) |
| pubmed:14556719 | a(MESH:"Neurofibrillary Tangles") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) |
| pubmed:27574109 | a(MESH:"Neurofibrillary Tangles") association a(CONSO:"Tau oligomers") |
| pubmed:27574109 | a(MESH:"Neurofibrillary Tangles") association p(CONSO:"phosphatase-activating domain") |
| pubmed:23528736 | a(MESH:"Neurofibrillary Tangles") association p(CONSO:"UBB+1") |
| pubmed:19293145 | p(CHEBI:amyloid-beta, var("?")) increases a(CONSO:"amyloid-beta aggregates") |
| pubmed:19293145 | a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") decreases path(MESH:"Alzheimer Disease") |
| pubmed:16273023 | a(CHEBI:"NMDA receptor antagonist") association bp(GO:"GO:0035249") |
| pubmed:16273023 | a(CHEBI:"NMDA receptor antagonist") decreases act(a(MESH:D009474)) |
| pubmed:21882945 | a(CHEBI:"NMDA receptor antagonist") positiveCorrelation bp(GO:cognition) |
| pubmed:19293145 | composite(p(CONSO:gamma-secretase), p(HGNC:APP), p(HGNC:BACE1)) directlyIncreases composite(a(CHEBI:"amyloid-beta polypeptide 40"), a(CHEBI:"amyloid-beta polypeptide 42")) |
| pubmed:19293145 | a(CONSO:"Abeta*56") decreases path(MESH:"Maze Learning") |
| pubmed:19293145 | g(HGNC:CHAT) association path(MESH:"Alzheimer Disease") |
| pubmed:19293145 | g(HGNC:ACHE) association path(MESH:"Alzheimer Disease") |
| pubmed:18986241 | path(MESH:Cognition) association p(HGNC:BCHE) |
| pubmed:18986241 | path(MESH:Cognition) association g(HGNC:NTRK1) |
| pubmed:18986241 | path(MESH:Cognition) association g(HGNC:NTRK2) |
| pubmed:18986241 | path(MESH:Cognition) association g(HGNC:NTRK3) |
| pubmed:18986241 | path(MESH:Cognition) negativeCorrelation r(HGNC:CHRNA7) |
| pubmed:18986241 | path(MESH:Cognition) association act(p(HGNC:GAL)) |
| pubmed:29687724 | path(MESH:Cognition) association path(MESH:"Huntington Disease") |
| pubmed:19293145 | a(CHEBI:dihydro-beta-erythroidine) decreases act(a(CHEBI:nicotine)) |
| pubmed:19293145 | a(CHEBI:dihydro-beta-erythroidine) decreases act(a(CHEBI:nicotine)) |
| pubmed:19293145 | a(CHEBI:dihydro-beta-erythroidine) decreases act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:19293145 | a(CHEBI:dihydro-beta-erythroidine) decreases bp(MESH:Neuroprotection) |
| pubmed:17009926 | a(CHEBI:dihydro-beta-erythroidine) decreases act(p(HGNC:CHRNB2)) |
| pubmed:17009926 | a(CHEBI:dihydro-beta-erythroidine) decreases bp(GO:memory) |
| pubmed:19293145 | a(CHEBI:Mecamylamine) decreases act(a(CHEBI:nicotine)) |
| pubmed:28391535 | a(CHEBI:Mecamylamine) decreases act(a(CHEBI:nicotine)) |
| pubmed:17009926 | a(CHEBI:Mecamylamine) isA a(CHEBI:"nicotinic antagonist") |
| pubmed:17009926 | a(CHEBI:Mecamylamine) decreases path(MESH:Attention) |
| pubmed:26813123 | a(CHEBI:Mecamylamine) decreases act(a(MESH:"Hypothalamo-Hypophyseal System")) |
| pubmed:11230871 | a(CHEBI:Mecamylamine) decreases bp(GO:cognition) |
| pubmed:19721446 | a(CHEBI:Mecamylamine) decreases bp(GO:cognition) |
| pubmed:28391535 | a(CHEBI:Mecamylamine) decreases act(a(MESH:"Receptors, Nicotinic")) |
| pubmed:28391535 | a(CHEBI:Mecamylamine) decreases act(a(MESH:"Receptors, Nicotinic")) |
| pubmed:28391535 | a(CHEBI:Mecamylamine) decreases path(MESH:Hypertension) |
| pubmed:28391535 | a(CHEBI:Mecamylamine) increases path(MESH:Tremor) |
| pubmed:28391535 | a(CHEBI:Mecamylamine) increases path(MESH:Confusion) |
| pubmed:28391535 | a(CHEBI:Mecamylamine) increases path(MESH:Seizures) |
| pubmed:28391535 | a(CHEBI:Mecamylamine) increases path(MESH:"Bipolar Disorder") |
| pubmed:28391535 | a(CHEBI:Mecamylamine) increases path(MESH:Depression) |
| pubmed:28391535 | a(CHEBI:Mecamylamine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:23038257 | bp(GO:"intracellular receptor signaling pathway") association p(HGNC:CHRNA4) |
| pubmed:19293145 | a(MESH:Bungarotoxins) decreases act(a(CHEBI:amyloid-beta)) |
| pubmed:19293145 | a(MESH:Bungarotoxins) decreases complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) |
| pubmed:19293145 | act(a(MESH:Bungarotoxins)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23038257 | a(MESH:Bungarotoxins) decreases bp(GO:"neuromuscular synaptic transmission") |
| pubmed:23038257 | a(MESH:Bungarotoxins) decreases act(a(MESH:"Electric Organ")) |
| pubmed:23038257 | a(MESH:Bungarotoxins) decreases act(a(CHEBI:decamethonium)) |
| pubmed:25514383 | a(MESH:Bungarotoxins) decreases complex(a(CHEBI:amyloid-beta), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:19293145 | composite(a(CHEBI:"3',5'-cyclic AMP"), p(FPLX:PKC)) increases p(HGNC:CHRNA7) |
| pubmed:19293145 | act(a(CHEBI:ethanol)) increases path(CONSO:neurotoxicity) |
| pubmed:19293145 | a(MESH:Serum) decreases bp(GO:"cell death") |
| pubmed:19293145 | a(CHEBI:thapsigargin) increases bp(GO:"cell death") |
| pubmed:19293145 | a(CHEBI:thapsigargin) decreases bp(GO:"sarcoplasmic reticulum calcium ion transport") |
| pubmed:20556492 | a(CHEBI:thapsigargin) decreases bp(GO:"regulation of membrane potential") |
| pubmed:20556492 | a(CHEBI:thapsigargin) increases path(HP:"Increased reactive oxygen species production") |
| pubmed:28148553 | a(CHEBI:thapsigargin) increases bp(MESH:"Unfolded Protein Response") |
| pubmed:28148553 | a(CHEBI:thapsigargin) positiveCorrelation p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | a(CHEBI:thapsigargin) positiveCorrelation p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21722302 | a(CHEBI:thapsigargin) increases bp(GO:autophagy) |
| pubmed:30740335 | a(CHEBI:thapsigargin) increases path(MESH:"Endoplasmic Reticulum Stress") |
| pubmed:29024336 | a(CHEBI:thapsigargin) increases bp(GO:"response to endoplasmic reticulum stress") |
| pubmed:19293145 | act(a(CHEBI:"L-glutamate(2-)")) increases path(CONSO:neurotoxicity) |
| pubmed:19293145 | act(a(CHEBI:"L-glutamate(2-)")) increases path(CONSO:neurotoxicity) |
| pubmed:19293145 | act(a(MESH:"Vagus Nerve")) increases act(p(HGNC:CHRNA7)) |
| pubmed:19293145 | bp(GO:"negative regulation of apoptotic process") association a(CHEBI:nicotine) |
| pubmed:19293145 | p(FPLX:SRC) increases act(a(CHEBI:nicotine)) |
| pubmed:17009926 | act(p(FPLX:SRC), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CHRNA7, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22040696 | act(p(FPLX:SRC), ma(go:0016301 ! "kinase activity")) increases p(FPLX:CHRN, pmod(go:0006468 ! "protein phosphorylation", Tyr)) |
| pubmed:22040696 | act(p(FPLX:SRC), ma(go:0016301 ! "kinase activity")) increases p(FPLX:CHRN, pmod(go:0006468 ! "protein phosphorylation", Tyr)) |
| pubmed:19293145 | a(MESH:"Nicotinic Antagonists") decreases bp(MESH:Neuroprotection) |
| pubmed:19293145 | tloc(p(HGNC:BAX), fromLoc(GO:cytosol), toLoc(GO:mitochondrion)) increases bp(GO:"apoptotic process") |
| pubmed:21722302 | p(HGNC:BAX) increases act(p(HGNC:ERN1), ma(go:0016301 ! "kinase activity")) |
| pubmed:21722302 | p(HGNC:BAX) increases act(p(HGNC:ERN1), ma(MESH:Endoribonucleases)) |
| pubmed:21722302 | p(HGNC:BAX) association bp(MESH:Apoptosis) |
| pubmed:21722302 | p(HGNC:BAX) increases bp(GO:"mitochondrial outer membrane permeabilization") |
| pubmed:21722302 | p(HGNC:BAX) increases complex(GO:"mitochondrial permeability transition pore complex") |
| pubmed:19293145 | complex(p(FPLX:AKT), p(HGNC:AGAP2)) increases act(p(FPLX:AKT)) |
| pubmed:19293145 | p(MGI:Fyn) decreases bp(MESH:Neuroprotection) |
| pubmed:18096814 | p(MGI:Fyn, loc(GO:"membrane raft")) negativeCorrelation a(CHEBI:"2-bromohexadecanoic acid") |
| pubmed:18096814 | p(MGI:Fyn) regulates tloc(p(MGI:Mapt), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) |
| pubmed:25125464 | p(MGI:Fyn) positiveCorrelation a(GO:"neuron spine") |
| pubmed:25125464 | p(MGI:Fyn) increases p(MGI:Grin2b, pmod(go:0006468 ! "protein phosphorylation", Tyr, 1472)) |
| pubmed:25125464 | act(p(MGI:Fyn)) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:25125464 | act(p(MGI:Fyn)) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:19293145 | p(HGNC:JAK2) increases bp(MESH:Neuroprotection) |
| pubmed:19293145 | p(HGNC:JAK2) association bp(MESH:Neuroprotection) |
| pubmed:19293145 | p(HGNC:JAK2) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19293145 | p(HGNC:JAK2) association act(p(HGNC:STAT3)) |
| pubmed:26979166 | act(p(HGNC:JAK2)) directlyIncreases act(p(HGNC:STAT3)) |
| pubmed:19293145 | act(p(HGNC:JAK2)) regulates act(a(CHEBI:nicotine)) |
| pubmed:19293145 | p(HGNC:JAK2) increases act(p(HGNC:FYN)) |
| pubmed:26979166 | act(p(HGNC:JAK2)) directlyIncreases p(FPLX:"PI3K_p85", pmod(go:0006468 ! "protein phosphorylation", Tyr)) |
| pubmed:26979166 | act(p(HGNC:JAK2)) decreases act(p(MESH:"NF-kappa B")) |
| pubmed:26979166 | act(p(HGNC:JAK2)) increases act(p(HGNC:GABPA), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:19293145 | complex(p(HGNC:FYN), p(HGNC:MAPT)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | complex(p(HGNC:FYN), p(HGNC:MAPT)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26631930 | complex(p(HGNC:FYN), p(HGNC:MAPT)) regulates path(CONSO:Excitotoxicity) |
| pubmed:18680553 | complex(p(HGNC:FYN), p(HGNC:MAPT)) positiveCorrelation bp(GO:myelination) |
| pubmed:19293145 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr)) association p(HGNC:PTK2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases a(CONSO:"Tau aggregates") |
| pubmed:19293145 | p(HGNC:PTK2, pmod(go:0006468 ! "protein phosphorylation")) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr)) |
| pubmed:19293145 | p(HGNC:PTK2, pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(HGNC:PTK2)) |
| pubmed:19293145 | p(HGNC:CHRNA7, pmod(go:0006468 ! "protein phosphorylation")) decreases act(a(CHEBI:acetylcholine)) |
| pubmed:23038257 | p(HGNC:CHRNA7, pmod(go:0006468 ! "protein phosphorylation")) increases act(a(MESH:"Motor Endplate"), ma(GO:localization)) |
| pubmed:17009926 | p(HGNC:CHRNA7, pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(HGNC:CHRNA7)) |
| pubmed:19293145 | a(CHEBI:estradiol) decreases act(a(CHEBI:amyloid-beta)) |
| pubmed:19293145 | act(p(RGD:Chrna7)) regulates act(a(CHEBI:nicotine)) |
| pubmed:19293145 | act(p(RGD:Chrna7)) decreases act(a(CHEBI:"glutamate(2-)")) |
| pubmed:19293145 | composite(p(HGNC:JAK2), p(HGNC:STAT3)) regulates act(p(HGNC:INS)) |
| pubmed:19293145 | act(p(HGNC:INS)) association path(MESH:"Alzheimer Disease") |
| pubmed:30606258 | p(HGNC:INS) increases p(HGNC:AKT1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30606258 | p(HGNC:INS) decreases p(HGNC:GSK3A, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30606258 | p(HGNC:INS) decreases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30606258 | act(p(HGNC:INS)) negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) |
| pubmed:30606258 | act(p(HGNC:INS)) negativeCorrelation p(HGNCGENEFAMILY:"MTOR complex 1") |
| pubmed:30606258 | act(p(HGNC:INS)) negativeCorrelation act(p(HGNC:RPS6KB1)) |
| pubmed:26195256 | p(HGNC:INS) increases a(CHEBI:amyloid-beta) |
| pubmed:19293145 | g(HGNC:NIN) association g(HGNC:GSK3B) |
| pubmed:19293145 | g(HGNC:GSK3B) association g(HGNC:NIN) |
| pubmed:19293145 | act(p(HGNC:MYC)) increases bp(GO:"apoptotic process") |
| pubmed:23454242 | p(HGNC:MYC) decreases act(p(FPLX:PPP2C)) |
| pubmed:19293145 | complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases bp(GO:"ERK1 and ERK2 cascade") |
| pubmed:19293145 | complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases act(p(FPLX:JNK)) |
| pubmed:19293145 | complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases bp(GO:"MAPK cascade") |
| pubmed:29428175 | complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases bp(GO:"activation of phospholipase C activity") |
| pubmed:29428175 | complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases act(p(HGNC:CHRNA7)) |
| pubmed:19293145 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19293145 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19293145 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") causesNoChange p(HGNC:MAPK14, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19293145 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") causesNoChange p(HGNC:MAPK8, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(GO:cognition) |
| pubmed:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases path(MESH:"Memory, Episodic") |
| pubmed:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:Neuroprotection) |
| pubmed:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") decreases act(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pubmed:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") decreases bp(MESH:"Cell Survival") |
| pubmed:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:"Sensory Gating") |
| pubmed:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:"Sensory Gating") |
| pubmed:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases act(p(HGNC:CHRNA7)) |
| pubmed:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(GO:memory) |
| pubmed:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases path(MESH:Attention) |
| pubmed:22530628 | p(HGNC:MAPK3) increases bp(MESH:"Neuronal Plasticity") |
| pubmed:22530628 | p(HGNC:MAPK3) increases bp(GO:cognition) |
| pubmed:22530628 | p(HGNC:MAPK3) increases bp(GO:"learning or memory") |
| pubmed:22530628 | act(p(HGNC:MAPK3)) increases p(HGNC:ARC) |
| pubmed:22530628 | p(HGNC:MAPK3) increases p(HGNC:ARC) |
| pubmed:23528736 | p(HGNC:MAPK8) increases bp(GO:autophagy) |
| pubmed:23528736 | p(HGNC:MAPK8) increases p(HGNC:BCL2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23528736 | p(HGNC:MAPK8) increases p(HGNC:BCL2L11, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:11943212 | p(HGNC:MAPK8) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) |
| pubmed:19293145 | a(MESH:A-582941) increases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19293145 | a(MESH:A-582941) increases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19293145 | a(CHEBI:SL-327) decreases act(a(MESH:A-582941)) |
| pubmed:19293145 | composite(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) increases bp(GO:"MAPK cascade") |
| pubmed:19293145 | composite(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") |
| pubmed:19293145 | composite(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) increases act(p(HGNC:MAPK1)) |
| pubmed:19293145 | composite(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) increases p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19293145 | composite(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:19293145 | composite(p(FPLX:ERK), p(FPLX:RAF), p(FPLX:RAS), p(HGNC:MAP2K1)) increases act(a(CHEBI:nicotine)) |
| pubmed:19293145 | composite(p(FPLX:JAK), p(HGNC:STAT3)) increases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19293145 | act(a(CHEBI:"N-methyl-D-aspartic acid")) increases path(CONSO:neurotoxicity) |
| pubmed:19293145 | a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole") increases act(p(RGD:Chrna7)) |
| pubmed:19721446 | a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole") association path(MESH:"Attention Deficit Disorder with Hyperactivity") |
| pubmed:19293145 | a(CHEBI:"calcium(1+)") decreases act(a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole")) |
| pubmed:19293145 | p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors") association a(CHEBI:nicotine) |
| pubmed:19293145 | act(p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors")) association a(CHEBI:"calcium(2+)") |
| pubmed:26979166 | p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors") increases tloc(a(CHEBI:"calcium ion"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:19293145 | p(HGNCGENEFAMILY:"Ryanodine receptors") association a(CHEBI:nicotine) |
| pubmed:19293145 | act(p(HGNCGENEFAMILY:"Ryanodine receptors")) increases bp(GO:"cellular calcium ion homeostasis") |
| pubmed:29428175 | p(HGNCGENEFAMILY:"Ryanodine receptors") increases a(CHEBI:"calcium ion", loc(MESH:"Intracellular Space")) |
| pubmed:26979166 | p(HGNCGENEFAMILY:"Ryanodine receptors") increases tloc(a(CHEBI:"calcium ion"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:19293145 | composite(a(CHEBI:"calcium(2+)"), a(MESH:Calcineurin), p(HGNC:PTPN5)) increases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27013968 | p(HGNC:PTPN5) negativeCorrelation p(HGNC:HTT, pmod(HBP:"CAG repeats")) |
| pubmed:19293145 | bp(GO:"regulation of cytosolic calcium ion concentration") association path(MESH:"Alzheimer Disease") |
| pubmed:19293145 | composite(a(CHEBI:amyloid-beta), complex(p(HGNC:CHRNA3), p(HGNC:CHRNB2)), p(HGNC:CHRNA7)) increases bp(GO:"cellular calcium ion homeostasis") |
| pubmed:19293145 | composite(p(HGNC:JAK2), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association bp(GO:"calcium-mediated signaling") |
| pubmed:19293145 | composite(p(HGNC:MAPK14), p(HGNC:MAPK8)) decreases bp(GO:"long-term synaptic potentiation") |
| pubmed:19293145 | p(HGNC:CHRNA7, var("p.Trp55Ala")) decreases complex(p(HGNC:APOE), p(HGNC:CHRNA7)) |
| pubmed:19293145 | act(a(CHEBI:carbachol)) increases act(a(CHEBI:phosphatidylinositol), ma(MESH:Hydrolysis)) |
| pubmed:24590577 | a(CHEBI:carbachol) increases act(p(HGNC:CHRM1)) |
| pubmed:26751493 | a(CHEBI:phosphatidylinositol) association p(CONSO:"projection domain") |
| pubmed:19293145 | complex(a(CHEBI:amyloid-beta), g(CONSO:"APOE e4")) decreases act(a(CHEBI:carbachol)) |
| pubmed:19293145 | a(CHEBI:wortmannin) decreases act(a(CHEBI:estrogen)) |
| pubmed:30145931 | a(CHEBI:wortmannin) decreases bp(GO:autophagy) |
| pubmed:30145931 | a(CHEBI:wortmannin) increases p(HGNC:MAPT) |
| pubmed:30145931 | a(CHEBI:wortmannin) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) |
| pubmed:30145931 | a(CHEBI:wortmannin) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:19293145 | composite(a(CHEBI:nicotine), complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) decreases tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:19293145 | composite(a(CHEBI:nicotine), complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) causesNoChange r(HGNC:APP) |
| pubmed:19293145 | complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) increases path(CONSO:neurotoxicity) |
| pubmed:19293145 | complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) decreases complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) |
| pubmed:22530628 | complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) increases p(HGNC:CHRNA7) |
| pubmed:22530628 | complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) decreases p(HGNC:CHRNA7) |
| pubmed:26979166 | complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7)) |
| pubmed:22040696 | complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7)) |
| pubmed:18986241 | complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) increases r(HGNC:CHRNA7) |
| pubmed:18986241 | complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) decreases bp(GO:"synaptic transmission, cholinergic") |
| pubmed:22040696 | complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) increases bp(GO:"neuron death") |
| pubmed:19293145 | composite(p(HGNC:MAPK1), p(HGNC:MAPK3)) association bp(GO:memory) |
| pubmed:19293145 | composite(p(FPLX:ERK), p(HGNC:CHRNA7)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19293145 | composite(p(FPLX:JNK), p(HGNC:CHRNA7)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19293145 | complex(p(FPLX:AKT), p(HGNC:BAD)) regulates bp(GO:"apoptotic process") |
| pubmed:19293145 | bp(GO:"insulin receptor signaling pathway") association p(FPLX:AKT) |
| pubmed:24653673 | bp(GO:"insulin receptor signaling pathway") increases p(HGNC:PPP2CA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) |
| pubmed:24653673 | bp(GO:"insulin receptor signaling pathway") increases p(HGNC:PPP2CB, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) |
| pubmed:27299292 | bp(GO:"insulin receptor signaling pathway") association p(HGNC:PPARGC1A) |
| pubmed:29191965 | bp(GO:"insulin receptor signaling pathway") association a(CHEBI:ethosuximide) |
| pubmed:19293145 | bp(GO:"choline transport") association a(CHEBI:amyloid-beta) |
| pubmed:19293145 | complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) |
| pubmed:19293145 | complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) |
| pubmed:19293145 | complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:methyllycaconitine), p(HGNC:CHRNA7)) |
| pubmed:27190210 | a(CHEBI:methyllycaconitine) decreases p(HGNC:CHRNA7) |
| pubmed:25514383 | a(CHEBI:methyllycaconitine) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:25514383 | a(CHEBI:methyllycaconitine) decreases bp(HP:Neurodegeneration) |
| pubmed:19293145 | p(HGNC:APP, frag("25_35")) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19293145 | p(HGNC:APP, frag("25_35")) increases act(p(HGNC:CHRNA7)) |
| pubmed:19721446 | complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2)) association a(MESH:"Dopaminergic Neurons") |
| pubmed:26979166 | p(HGNC:CHRNA7, var("?")) positiveCorrelation path(DOID:schizophrenia) |
| pubmed:21482353 | p(HGNC:CHRNA7, var("?")) positiveCorrelation path(MESH:Schizophrenia) |
| pubmed:19293145 | p(HGNC:MAPT, var("p.Lys595Asp")) increases path(HP:Neurodegeneration) |
| pubmed:19293145 | p(HGNC:MAPT, var("p.Met596Leu")) increases path(HP:Neurodegeneration) |
| pubmed:19293145 | composite(a(CHEBI:amyloid-beta), p(MGI:Ache)) increases r(MGI:Chrna7) |
| pubmed:19293145 | composite(a(CHEBI:amyloid-beta), p(MGI:Ache)) causesNoChange r(MGI:Chrna4) |
| pubmed:23038257 | a(CHEBI:"4-(trimethylammonium)benzenediazonium") decreases act(a(MESH:"Electric Organ")) |
| pubmed:23038257 | a(MESH:Curare) decreases act(a(CHEBI:"4-(trimethylammonium)benzenediazonium")) |
| pubmed:23038257 | a(MESH:Curare) increases act(a(MESH:"Receptors, Nicotinic")) |
| pubmed:23038257 | a(CHEBI:"4-(N-Maleimido)phenyltrimethylammonium iodide") increases act(a(MESH:"Affinity Labels")) |
| pubmed:23038257 | a(CHEBI:decamethonium) decreases act(a(MESH:"Receptors, Nicotinic")) |
| pubmed:26813123 | a(MESH:"Receptors, Nicotinic") increases act(a(MESH:"Hypothalamo-Hypophyseal System")) |
| pubmed:26813123 | act(a(MESH:"Receptors, Nicotinic")) increases bp(MESH:"Synaptic Transmission") |
| pubmed:26813123 | a(MESH:"Receptors, Nicotinic") regulates tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pubmed:26813123 | act(a(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular region"), toLoc(GO:synapse)) |
| pubmed:26813123 | act(a(MESH:"Receptors, Nicotinic")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19721446 | a(MESH:"Receptors, Nicotinic") regulates tloc(a(CHEBI:serotonin), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:23038257 | a(MESH:"Gallamine Triethiodide") decreases act(a(MESH:"Receptors, Nicotinic")) |
| pubmed:28901280 | p(MESH:"Receptors, Nicotinic") isA p(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors") |
| pubmed:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:Learning) |
| pubmed:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:Memory) |
| pubmed:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:Arousal) |
| pubmed:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:Reward) |
| pubmed:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:"Motor Activity") |
| pubmed:28901280 | p(MESH:"Receptors, Nicotinic") association bp(MESH:Analgesia) |
| pubmed:28901280 | p(MESH:"Receptors, Nicotinic") association bp(GO:"depolarization of postsynaptic membrane") |
| pubmed:28901280 | p(MESH:"Receptors, Nicotinic") association bp(GO:"action potential initiation") |
| pubmed:28901280 | p(MESH:"Receptors, Nicotinic") association bp(GO:"cell proliferation") |
| pubmed:28901280 | p(MESH:"Receptors, Nicotinic") association bp(GO:"cell differentiation") |
| pubmed:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:"Cognition Disorders") |
| pubmed:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:Anxiety) |
| pubmed:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:Depression) |
| pubmed:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:"Alzheimer Disease") |
| pubmed:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:"Parkinson Disease") |
| pubmed:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:Pain) |
| pubmed:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:Epilepsy) |
| pubmed:28901280 | p(MESH:"Receptors, Nicotinic") association a(MESH:Neurons) |
| pubmed:28901280 | p(MESH:"Receptors, Nicotinic") positiveCorrelation bp(UBERON:0002138) |
| pubmed:23038257 | p(HGNC:SCNN1D) association a(CHEBI:chlorpromazine) |
| pubmed:23038257 | a(CHEBI:"zinc(2+)") increases act(p(MESH:"Receptors, Nicotinic")) |
| pubmed:19721446 | a(CHEBI:"zinc(2+)") decreases act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:2833519 | a(CHEBI:"zinc(2+)") increases act(p(HGNC:S100B)) |
| pubmed:23038257 | a(MESH:Galantamine) regulates act(p(MESH:"Receptors, Nicotinic")) |
| pubmed:23038257 | a(MESH:Ivermectin) increases act(p(HGNC:CHRNA7)) |
| pubmed:23038257 | p(HGNC:SCNN1D, var("?")) regulates act(a(MESH:Ivermectin)) |
| pubmed:23038257 | a(MESH:Anesthetics) decreases p(MESH:"Receptors, Nicotinic") |
| pubmed:23038257 | a(MESH:Anesthetics) increases p(MESH:"Receptors, GABA") |
| pubmed:19721446 | a(MESH:Anesthetics) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:23038257 | p(MESH:Agrin) increases p(HGNC:RAPSN, pmod(go:0006468 ! "protein phosphorylation", Tyr)) |
| pubmed:23038257 | p(HGNC:RAPSN, pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases act(a(MESH:"Motor Endplate"), ma(GO:localization)) |
| pubmed:22040696 | p(HGNC:RAPSN) increases bp(GO:"skeletal muscle acetylcholine-gated channel clustering") |
| pubmed:23038257 | p(MESH:"Receptors, Nicotinic", pmod(go:0006468 ! "protein phosphorylation")) increases act(p(MESH:Agrin)) |
| pubmed:24511233 | p(HGNC:CHRM1) association bp(GO:cognition) |
| pubmed:24511233 | act(p(HGNC:CHRM1)) increases bp(GO:cognition) |
| pubmed:24590577 | act(p(HGNC:CHRM1)) increases bp(GO:cognition) |
| pubmed:24511233 | p(HGNC:CHRM1) decreases act(a(CHEBI:amphetamine)) |
| pubmed:24511233 | p(HGNC:CHRM1) decreases bp(GO:"dopamine secretion, neurotransmission") |
| pubmed:24511233 | p(HGNC:CHRM1) increases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pubmed:24511233 | act(p(HGNC:CHRM1)) increases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pubmed:24511233 | p(HGNC:CHRM1) increases bp(GO:"long-term synaptic potentiation") |
| pubmed:24511233 | act(p(HGNC:CHRM1)) increases a(CHEBI:acetylcholine) |
| pubmed:24511233 | act(p(HGNC:CHRM1)) increases deg(p(CONSO:sAPP-alpha)) |
| pubmed:24590577 | act(p(HGNC:CHRM1)) increases p(CONSO:sAPP-alpha) |
| pubmed:26813123 | act(p(HGNC:CHRM1)) association a(MESH:"Cholinergic Neurons") |
| pubmed:26813123 | act(p(HGNC:CHRM1)) association path(MESH:"Cognitive Dysfunction") |
| pubmed:18986241 | p(HGNC:CHRM1) association path(MESH:"Cognitive Dysfunction") |
| pubmed:26813123 | act(p(HGNC:CHRM1)) association act(p(HGNC:MAPT)) |
| pubmed:26813123 | act(p(HGNC:CHRM1)) association act(a(CHEBI:amyloid-beta)) |
| pubmed:24590577 | act(p(HGNC:CHRM1)) decreases a(CHEBI:amyloid-beta) |
| pubmed:26813123 | act(p(HGNC:CHRM1)) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:26813123 | act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) |
| pubmed:24590577 | act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) |
| pubmed:24590577 | act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) |
| pubmed:24590577 | act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) |
| pubmed:26813123 | act(p(HGNC:CHRM1)) decreases act(p(HGNC:GSK3B)) |
| pubmed:24590577 | act(p(HGNC:CHRM1)) decreases act(p(HGNC:GSK3B)) |
| pubmed:24590577 | p(HGNC:CHRM1) association a(MESH:Hippocampus) |
| pubmed:24590577 | p(HGNC:CHRM1) association a(MESH:"Cerebral Cortex") |
| pubmed:24590577 | p(HGNC:CHRM1) association a(MESH:"Corpus Striatum") |
| pubmed:24590577 | p(HGNC:CHRM1) association a(MESH:Thalamus) |
| pubmed:24590577 | p(HGNC:CHRM1) association bp(GO:"regulation of synaptic plasticity") |
| pubmed:24590577 | p(HGNC:CHRM1) association bp(GO:learning) |
| pubmed:24590577 | p(HGNC:CHRM1) association bp(GO:memory) |
| pubmed:24590577 | p(HGNC:CHRM1) association bp(GO:"neuronal signal transduction") |
| pubmed:24590577 | p(HGNC:CHRM1) association bp(GO:"neuron differentiation") |
| pubmed:24590577 | p(HGNC:CHRM1) regulates bp(GO:"synaptic transmission, glutamatergic") |
| pubmed:24590577 | act(p(HGNC:CHRM1)) increases bp(GO:"ERK1 and ERK2 cascade") |
| pubmed:24590577 | act(p(HGNC:CHRM1)) causesNoChange bp(GO:"ERK1 and ERK2 cascade") |
| pubmed:24590577 | act(p(HGNC:CHRM1)) increases p(HGNC:BACE1) |
| pubmed:24590577 | p(HGNC:CHRM1) regulates p(HGNC:BACE1) |
| pubmed:24590577 | act(p(HGNC:CHRM1)) increases bp(GO:"MAPK cascade") |
| pubmed:24590577 | act(p(HGNC:CHRM1)) decreases path(CONSO:neurotoxicity) |
| pubmed:24590577 | act(p(HGNC:CHRM1)) increases bp(GO:"Wnt signaling pathway") |
| pubmed:24590577 | act(p(HGNC:CHRM1)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24590577 | act(p(HGNC:CHRM1)) decreases path(MESH:"DNA Damage") |
| pubmed:24590577 | act(p(HGNC:CHRM1)) decreases path(MESH:"Oxidative Stress") |
| pubmed:24590577 | act(p(HGNC:CHRM1)) decreases act(p(HGNCGENEFAMILY:Caspases)) |
| pubmed:24590577 | act(p(HGNC:CHRM1)) decreases bp(GO:"cell death") |
| pubmed:18986241 | p(HGNC:CHRM1) association path(MESH:Tauopathies) |
| pubmed:18986241 | p(HGNC:CHRM1) association path(MESH:Amyloidosis) |
| pubmed:26813123 | p(HGNC:CHRM2) decreases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pubmed:26813123 | act(p(HGNC:CHRM2)) increases a(CHEBI:amyloid-beta) |
| pubmed:24590577 | p(HGNC:CHRM2) association a(MESH:Hippocampus) |
| pubmed:24590577 | p(HGNC:CHRM2) association a(MESH:Neocortex) |
| pubmed:24590577 | p(HGNC:CHRM2) decreases act(a(CHEBI:dopamine)) |
| pubmed:24590577 | p(HGNC:CHRM3) association a(MESH:Hypothalamus) |
| pubmed:24590577 | p(HGNC:CHRM3) association a(MESH:Hippocampus) |
| pubmed:24511233 | p(HGNC:CHRM4) association path(MESH:"Avoidance Learning") |
| pubmed:24511233 | p(HGNC:CHRM4) association a(MESH:Hippocampus) |
| pubmed:24511233 | p(HGNC:CHRM4) association a(MESH:"Corpus Striatum") |
| pubmed:24590577 | p(HGNC:CHRM4) association a(MESH:"Corpus Striatum") |
| pubmed:24511233 | p(HGNC:CHRM4) association a(MESH:Neocortex) |
| pubmed:24511233 | p(HGNC:CHRM4) regulates bp(GO:"synaptic transmission, dopaminergic") |
| pubmed:24511233 | act(p(HGNC:CHRM4)) decreases bp(GO:"synaptic transmission, glutamatergic") |
| pubmed:24511233 | p(HGNC:CHRM4) regulates bp(GO:cognition) |
| pubmed:24590577 | p(HGNC:CHRM4) association path(MESH:"Psychotic Disorders") |
| pubmed:24590577 | p(HGNC:CHRM4) association path(MESH:"Parkinson Disease") |
| pubmed:24590577 | p(HGNC:CHRM4) decreases act(p(HGNC:DRD1)) |
| pubmed:24590577 | p(HGNC:CHRM5) increases bp(GO:"response to drug") |
| pubmed:24590577 | p(HGNC:CHRM5) increases act(a(CHEBI:morphine)) |
| pubmed:24590577 | p(HGNC:CHRM5) increases act(a(CHEBI:cocaine)) |
| pubmed:24511233 | complex(p(HGNC:CHRM1), p(HGNC:GNAQ)) increases bp(GO:"calcium ion transport") |
| pubmed:24511233 | complex(p(HGNC:CHRM1), p(HGNC:GNAQ)) increases a(MESH:"Inositol 1,4,5-Trisphosphate") |
| pubmed:26088141 | p(HGNC:GNAQ) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ)) |
| pubmed:24511233 | complex(p(HGNC:CHRM3), p(HGNC:GNAQ)) increases bp(GO:"calcium ion transport") |
| pubmed:24511233 | complex(p(HGNC:CHRM3), p(HGNC:GNAQ)) increases a(MESH:"Inositol 1,4,5-Trisphosphate") |
| pubmed:24511233 | complex(p(HGNC:CHRM5), p(HGNC:GNAQ)) increases bp(GO:"calcium ion transport") |
| pubmed:24511233 | complex(p(HGNC:CHRM5), p(HGNC:GNAQ)) increases a(MESH:"Inositol 1,4,5-Trisphosphate") |
| pubmed:24511233 | complex(p(HGNC:CHRM2), p(HGNC:GNAI1)) decreases a(CHEBI:"3',5'-cyclic AMP") |
| pubmed:26088141 | p(HGNC:GNAI1) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAI1)) |
| pubmed:24511233 | complex(p(HGNC:CHRM4), p(HGNC:GNAI1)) decreases a(CHEBI:"3',5'-cyclic AMP") |
| pubmed:24511233 | a(MESH:"Muscarinic Antagonists") decreases bp(GO:cognition) |
| pubmed:24511233 | a(MESH:"Muscarinic Antagonists") increases path(MESH:"Cognitive Dysfunction") |
| pubmed:24511233 | a(MESH:"Muscarinic Antagonists") association path(MESH:"Mental Processes") |
| pubmed:24511233 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases bp(GO:"synaptic transmission, cholinergic") |
| pubmed:26813123 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases bp(GO:"synaptic transmission, cholinergic") |
| pubmed:24511233 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases bp(GO:cognition) |
| pubmed:24511233 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases path(MESH:"Mental Processes") |
| pubmed:24511233 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") association a(MESH:"Cardiovascular System") |
| pubmed:24511233 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") association a(MESH:"Gastrointestinal Tract") |
| pubmed:17009926 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") decreases path(MESH:"Alzheimer Disease") |
| pubmed:17009926 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") decreases act(p(HGNC:ACHE)) |
| pubmed:17009926 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") decreases rxn(reactants(a(CHEBI:acetylcholine)), products(a(CHEBI:acetate), a(CHEBI:choline))) |
| pubmed:17009926 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases act(p(FPLX:CHRN)) |
| pubmed:24511233 | path(MESH:"Mental Processes") association a(MESH:"Muscarinic Antagonists") |
| pubmed:24511233 | a(MESH:"Cardiovascular System") association a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") |
| pubmed:24590577 | a(MESH:"Cardiovascular System") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pubmed:24511233 | a(MESH:"Gastrointestinal Tract") association a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") |
| pubmed:24511233 | a(MESH:"Gastrointestinal Tract") association a(CHEBI:xanomeline) |
| pubmed:24590577 | a(MESH:"Gastrointestinal Tract") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pubmed:29626319 | a(MESH:"Gastrointestinal Tract") decreases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | a(MESH:"Gastrointestinal Tract") decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pubmed:29626319 | a(MESH:"Gastrointestinal Tract") causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:24511233 | path(MESH:Anhedonia) biomarkerFor path(MESH:Schizophrenia) |
| pubmed:24511233 | path(MESH:"Social Isolation") biomarkerFor path(MESH:Schizophrenia) |
| pubmed:30988501 | path(MESH:"Social Isolation") increases deg(a(MESH:"Blood-Brain Barrier")) |
| pubmed:24511233 | path(MESH:"Memory, Short-Term") association path(MESH:Schizophrenia) |
| pubmed:18986241 | path(MESH:"Memory, Short-Term") association path(MESH:"Cholinergic Neurons") |
| pubmed:24511233 | path(MESH:Attention) association path(MESH:Schizophrenia) |
| pubmed:17009926 | path(MESH:Attention) association p(FPLX:CHRN) |
| pubmed:22530628 | path(MESH:Attention) positiveCorrelation a(CHEBI:nicotine) |
| pubmed:22530628 | path(MESH:Attention) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:26813123 | path(MESH:Attention) association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:24590577 | path(MESH:Attention) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pubmed:25514383 | path(MESH:Attention) association a(HP:"cholinergic neuron") |
| pubmed:18986241 | path(MESH:Attention) association path(MESH:"Cholinergic Neurons") |
| pubmed:24511233 | a(CHEBI:"antipsychotic agent") regulates p(HGNC:DRD2) |
| pubmed:24511233 | a(CHEBI:"antipsychotic agent") causesNoChange bp(GO:cognition) |
| pubmed:23393546 | p(HGNC:DRD2) association path(DOID:"Huntington's disease") |
| pubmed:23393546 | p(HGNC:DRD2) association path(DOID:"Huntington's disease") |
| pubmed:24511233 | bp(GO:"gamma-aminobutyric acid signaling pathway") association path(MESH:Schizophrenia) |
| pubmed:24511233 | a(CHEBI:xanomeline) increases bp(GO:cognition) |
| pubmed:26813123 | a(CHEBI:xanomeline) increases bp(GO:cognition) |
| pubmed:24590577 | a(CHEBI:xanomeline) increases bp(GO:cognition) |
| pubmed:24511233 | a(CHEBI:xanomeline) decreases path(MESH:Hallucinations) |
| pubmed:26813123 | a(CHEBI:xanomeline) decreases path(MESH:Hallucinations) |
| pubmed:24511233 | a(CHEBI:xanomeline) decreases path(MESH:Delusions) |
| pubmed:24511233 | a(CHEBI:xanomeline) decreases path(MESH:Schizophrenia) |
| pubmed:24511233 | a(CHEBI:xanomeline) increases bp(GO:learning) |
| pubmed:24511233 | a(CHEBI:xanomeline) increases path(MESH:"Memory, Short-Term") |
| pubmed:24511233 | a(CHEBI:xanomeline) association a(MESH:"Gastrointestinal Tract") |
| pubmed:26813123 | a(CHEBI:xanomeline) increases bp(GO:memory) |
| pubmed:24590577 | a(CHEBI:xanomeline) increases bp(GO:memory) |
| pubmed:26813123 | a(CHEBI:xanomeline) decreases path(MESH:"Mood Disorders") |
| pubmed:26813123 | a(CHEBI:xanomeline) decreases path(MESH:"Psychomotor Agitation") |
| pubmed:24590577 | a(CHEBI:xanomeline) decreases path(MESH:"Psychotic Disorders") |
| pubmed:24590577 | a(CHEBI:xanomeline) decreases path(MESH:"Psychotic Disorders") |
| pubmed:24590577 | a(CHEBI:xanomeline) increases act(p(HGNC:CHRM1)) |
| pubmed:24590577 | a(CHEBI:xanomeline) increases act(p(HGNC:CHRM4)) |
| pubmed:24511233 | p(MGI:Chrm1) decreases act(a(CHEBI:amyloid-beta)) |
| pubmed:24590577 | p(MGI:Chrm1) increases bp(GO:cognition) |
| pubmed:24590577 | p(MGI:Chrm1) increases bp(GO:"long-term synaptic potentiation") |
| pubmed:24590577 | act(p(MGI:Chrm1)) decreases bp(CONSO:"APP processing") |
| pubmed:24590577 | act(p(MGI:Chrm1)) decreases path(MESH:"Plaque, Amyloid") |
| pubmed:18986241 | act(p(MGI:Chrm1)) increases act(p(MGI:Adam17)) |
| pubmed:24511233 | a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") increases act(p(HGNC:CHRM1)) |
| pubmed:24590577 | a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") increases bp(GO:cognition) |
| pubmed:24590577 | a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") association a(MESH:"Antipsychotic Agents") |
| pubmed:24511233 | a(MESH:"1-(3-(4-butyl-1-piperidinyl)propyl)-3,4-dihydro-2(1H)-quinolinone") increases act(p(HGNC:CHRM1)) |
| pubmed:24590577 | a(MESH:"1-(3-(4-butyl-1-piperidinyl)propyl)-3,4-dihydro-2(1H)-quinolinone") increases act(p(HGNC:CHRM1)) |
| pubmed:24590577 | a(MESH:"1-(3-(4-butyl-1-piperidinyl)propyl)-3,4-dihydro-2(1H)-quinolinone") increases act(a(MESH:"Pyramidal Cells")) |
| pubmed:24511233 | a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") increases act(p(HGNC:CHRM1)) |
| pubmed:24590577 | a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") increases act(p(HGNC:CHRM1)) |
| pubmed:24511233 | a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") decreases act(a(CHEBI:scopolamine)) |
| pubmed:24511233 | a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") decreases a(CHEBI:amyloid-beta) |
| pubmed:24590577 | a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") decreases a(CHEBI:amyloid-beta) |
| pubmed:24590577 | a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") increases bp(GO:"NMDA selective glutamate receptor signaling pathway") |
| pubmed:24511233 | act(a(CHEBI:scopolamine)) decreases bp(GO:"behavioral fear response") |
| pubmed:24511233 | a(MESH:VU0357017) increases complex(a(MESH:VU0357017), p(HGNC:CHRM1)) |
| pubmed:24511233 | a(MESH:VU0357017) decreases act(a(CHEBI:scopolamine)) |
| pubmed:24511233 | a(MESH:VU0357017) increases bp(GO:"behavioral fear response") |
| pubmed:24590577 | a(MESH:VU0357017) increases act(p(HGNC:CHRM1)) |
| pubmed:24590577 | a(MESH:VU0357017) causesNoChange act(p(HGNC:CHRM2)) |
| pubmed:24590577 | a(MESH:VU0357017) causesNoChange act(p(HGNC:CHRM5)) |
| pubmed:24590577 | a(MESH:VU0357017) decreases path(MESH:"Cognitive Dysfunction") |
| pubmed:24590577 | a(MESH:VU0357017) increases bp(GO:learning) |
| pubmed:24511233 | complex(a(MESH:VU0357017), p(HGNC:CHRM1)) increases act(p(HGNC:CHRM1)) |
| pubmed:24511233 | complex(a(MESH:"GSK 1034702"), p(HGNC:CHRM1)) increases bp(GO:cognition) |
| pubmed:24511233 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases act(p(HGNC:CHRM1)) |
| pubmed:24511233 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:"excitatory postsynaptic potential") |
| pubmed:24511233 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") decreases act(a(CHEBI:scopolamine)) |
| pubmed:24511233 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:"behavioral fear response") |
| pubmed:24511233 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:learning) |
| pubmed:24590577 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:learning) |
| pubmed:24511233 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:memory) |
| pubmed:24590577 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1)) |
| pubmed:24590577 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") regulates bp(CONSO:"APP processing") |
| pubmed:24511233 | a(MESH:"Prefrontal Cortex") association bp(GO:cognition) |
| pubmed:24511233 | a(MESH:"Prefrontal Cortex") association bp(GO:learning) |
| pubmed:24511233 | a(MESH:"Prefrontal Cortex") association bp(GO:memory) |
| pubmed:24511233 | a(MESH:"VU 0405652") increases act(p(HGNC:CHRM1)) |
| pubmed:24511233 | a(CONSO:VU0456940) increases act(p(HGNC:CHRM1)) |
| pubmed:24511233 | a(MESH:"6-(4-butylthio-1,2,5-thiadiazol-3-yl)-1-azabicyclo(3.2.1)octane") decreases act(a(CHEBI:apomorphine)) |
| pubmed:24511233 | a(MESH:"6-(4-butylthio-1,2,5-thiadiazol-3-yl)-1-azabicyclo(3.2.1)octane") decreases path(MESH:"Avoidance Learning") |
| pubmed:24511233 | act(a(CHEBI:apomorphine)) decreases bp(GO:"prepulse inhibition") |
| pubmed:24511233 | act(a(CHEBI:apomorphine)) decreases bp(GO:"prepulse inhibition") |
| pubmed:24511233 | path(MESH:"Avoidance Learning") association p(HGNC:CHRM4) |
| pubmed:24511233 | a(MESH:"Corpus Striatum") association p(HGNC:CHRM4) |
| pubmed:24590577 | a(MESH:"Corpus Striatum") association p(HGNC:CHRM4) |
| pubmed:24590577 | a(MESH:"Corpus Striatum") association p(HGNC:CHRM1) |
| pubmed:24762290 | a(MESH:"Corpus Striatum") association complex(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:30027901 | a(MESH:"Corpus Striatum") increases a(MESH:"GABAergic Neurons") |
| pubmed:24511233 | a(MESH:Neocortex) association p(HGNC:CHRM4) |
| pubmed:24590577 | a(MESH:Neocortex) association p(HGNC:CHRM2) |
| pubmed:24511233 | a(CONSO:VU10010) increases act(a(CHEBI:acetylcholine)) |
| pubmed:24511233 | a(CONSO:VU10010) increases act(p(HGNC:CHRM4)) |
| pubmed:24511233 | a(MESH:"3-amino-N-(4-methoxybenzyl)-4,6-dimethylthieno(2,3-b)pyridine-2-carboxamide") decreases act(a(CHEBI:amphetamine)) |
| pubmed:24511233 | a(CONSO:VU0152099) decreases act(a(CHEBI:amphetamine)) |
| pubmed:24511233 | a(MESH:"3-amino-5-chloro-6-methoxy-4-methyl-thieno(2,3-b)pyridine-2-carboxylic acid cyclopropylamide") decreases act(a(CHEBI:amphetamine)) |
| pubmed:11230871 | a(CHEBI:neurotransmitter) association bp(GO:cognition) |
| pubmed:14556719 | tloc(a(CHEBI:neurotransmitter), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association p(HGNC:SYT11, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:21787755 | path(MESH:Reward) association complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| pubmed:21787755 | path(MESH:Reward) association p(CONSO:"alpha-6-containing nAChR") |
| pubmed:21787755 | path(MESH:Reward) association r(HGNC:CHRNA6) |
| pubmed:21787755 | path(MESH:Reward) association p(HGNC:CHRNA6) |
| pubmed:28901280 | path(MESH:Reward) association p(MESH:"Receptors, Nicotinic") |
| pubmed:27190210 | path(DOID:schizophrenia) decreases p(HGNC:CHRNA7) |
| pubmed:22530628 | path(DOID:schizophrenia) association p(HGNC:CHRNA7) |
| pubmed:26979166 | path(DOID:schizophrenia) decreases act(p(HGNC:CHRNA7)) |
| pubmed:27190210 | path(DOID:schizophrenia) association g(HGNC:CHRNA7) |
| pubmed:27190210 | path(DOID:schizophrenia) association g(HGNC:CHRFAM7A) |
| pubmed:29428175 | path(DOID:schizophrenia) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:26979166 | path(DOID:schizophrenia) increases path(HP:Delusions) |
| pubmed:26979166 | path(DOID:schizophrenia) increases path(HP:Hallucinations) |
| pubmed:26979166 | path(DOID:schizophrenia) increases path(HP:Anhedonia) |
| pubmed:26979166 | path(DOID:schizophrenia) decreases bp(GO:"learning or memory") |
| pubmed:26979166 | path(DOID:schizophrenia) decreases bp(GO:cognition) |
| pubmed:26979166 | path(DOID:schizophrenia) positiveCorrelation deg(a(MESH:"White Matter")) |
| pubmed:26979166 | path(DOID:schizophrenia) association path(MESH:Smoking) |
| pubmed:26979166 | path(DOID:schizophrenia) positiveCorrelation p(HGNC:CHRNA7, var("?")) |
| pubmed:26979166 | path(DOID:schizophrenia) positiveCorrelation p(HGNC:CHRFAM7A, var("?")) |
| pubmed:30562574 | path(DOID:schizophrenia) association p(HGNC:DPYSL2) |
| pubmed:30988501 | path(DOID:schizophrenia) increases path(MESH:Inflammation) |
| pubmed:30988501 | path(DOID:schizophrenia) positiveCorrelation p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") |
| pubmed:30988501 | path(DOID:schizophrenia) negativeCorrelation p(HGNC:IL6) |
| pubmed:30988501 | path(DOID:schizophrenia) negativeCorrelation p(HGNC:IL2) |
| pubmed:30988501 | path(DOID:schizophrenia) negativeCorrelation p(HGNC:IL1B) |
| pubmed:30988501 | path(DOID:schizophrenia) negativeCorrelation p(HGNC:IL17A) |
| pubmed:30988501 | path(DOID:schizophrenia) negativeCorrelation p(HGNC:CRP) |
| pubmed:30988501 | path(DOID:schizophrenia) positiveCorrelation p(HGNC:C4A) |
| pubmed:27190210 | path(DOID:"autism spectrum disorder") association g(HGNC:CHRNA7) |
| pubmed:30988501 | path(DOID:"autism spectrum disorder") isA path(MESH:"Neurodevelopmental Disorders") |
| pubmed:30988501 | path(DOID:"autism spectrum disorder") decreases bp(GO:"social behavior") |
| pubmed:30988501 | path(DOID:"autism spectrum disorder") positiveCorrelation bp(MESH:"Immunity, Maternally-Acquired") |
| pubmed:30988501 | path(DOID:"autism spectrum disorder") negativeCorrelation composite(a(CHEBI:minocycline), a(CHEBI:risperidone)) |
| pubmed:27190210 | path(DOID:"attention deficit hyperactivity disorder") association g(HGNC:CHRNA7) |
| pubmed:27190210 | path(DOID:epilepsy) association g(HGNC:CHRNA7) |
| pubmed:27190210 | bp(GO:"sensory processing") negativeCorrelation g(HGNC:CHRNA7) |
| pubmed:26813123 | bp(GO:"sensory processing") association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:21482353 | bp(GO:"sensory processing") association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:27190210 | g(HGNC:CHRFAM7A) association path(DOID:schizophrenia) |
| pubmed:26979166 | g(HGNC:CHRFAM7A) decreases act(p(HGNC:CHRNA7)) |
| pubmed:27190210 | p(HGNC:CHRFAM7A) decreases p(HGNC:CHRNA7) |
| pubmed:28901280 | p(HGNC:CHRFAM7A, loc(MESH:Oocytes)) decreases act(p(HGNC:CHRNA7, loc(MESH:Oocytes))) |
| pubmed:27190210 | complex(a(CONSO:"amyloid-beta 42 oligomers"), complex(CONSO:"alpha-7 beta-2 nAChR")) decreases act(complex(CONSO:"alpha-7 beta-2 nAChR")) |
| pubmed:25514383 | a(CONSO:"amyloid-beta 42 oligomers") increases bp(GO:"long-term synaptic potentiation") |
| pubmed:22419736 | a(CONSO:"amyloid-beta 42 oligomers") association path(MESH:Tauopathies) |
| pubmed:22419736 | a(CONSO:"amyloid-beta 42 oligomers") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:27190210 | complex(CONSO:"alpha-7 beta-2 nAChR") association path(DOID:"Alzheimer's disease") |
| pubmed:26979166 | complex(CONSO:"alpha-7 beta-2 nAChR") decreases deg(a(MESH:"Cholinergic Neurons")) |
| pubmed:27190210 | bp(GO:"cell migration") association p(HGNC:CHRNA7) |
| pubmed:27190210 | bp(GO:"regulation of phosphatidylinositol 3-kinase signaling") decreases tloc(a(MESH:Cytokines), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27190210 | bp(GO:"regulation of phosphatidylinositol 3-kinase signaling") decreases path(MESH:Inflammation) |
| pubmed:27190210 | bp(GO:"regulation of phosphatidylinositol 3-kinase signaling") increases p(HGNC:HMOX1) |
| pubmed:27190210 | bp(GO:"oxygen homeostasis") association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:27190210 | bp(GO:"glucose homeostasis") association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:27190210 | complex(a(PUBCHEM:305), p(HGNC:CHRNA7)) increases act(p(HGNC:CHRNA7)) |
| pubmed:26979166 | a(PUBCHEM:305) increases act(p(HGNC:CHRNA7)) |
| pubmed:27190210 | composite(p(CONSO:alpha-Bungarotoxin), p(HGNC:CHRNA7)) increases complex(p(CONSO:alpha-Bungarotoxin), p(HGNC:CHRNA7)) |
| pubmed:26472524 | composite(p(CONSO:alpha-Bungarotoxin), p(HGNC:CHRNA7)) increases complex(p(CONSO:alpha-Bungarotoxin), p(HGNC:CHRNA7)) |
| pubmed:27190210 | composite(a(PUBCHEM:187), p(HGNC:CHRNA7)) decreases complex(a(PUBCHEM:187), p(HGNC:CHRNA7)) |
| pubmed:27190210 | composite(a(CHEBI:nicotine), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) |
| pubmed:26979166 | composite(a(CHEBI:nicotine), p(HGNC:CHRNA7)) decreases path(MESH:Inflammation) |
| pubmed:27190210 | a(PUBCHEM:11243536) increases p(HGNC:CHRNA7) |
| pubmed:27190210 | a(PUBCHEM:5310971) increases p(HGNC:CHRNA7) |
| pubmed:27190210 | a(PUBCHEM:9797360) increases p(HGNC:CHRNA7) |
| pubmed:27190210 | a(PUBCHEM:5310985) increases p(HGNC:CHRNA7) |
| pubmed:26979166 | a(PUBCHEM:5310985) increases act(p(HGNC:CHRNA7)) |
| pubmed:26979166 | a(PUBCHEM:5310985) decreases path(DOID:aphasia) |
| pubmed:26979166 | a(PUBCHEM:5310985) increases path(HP:Anhedonia) |
| pubmed:27190210 | composite(p(HGNC:CHRNA7), p(HGNC:RIC3)) increases act(p(HGNC:CHRNA7, loc(GO:"cell surface"))) |
| pubmed:26979166 | p(HGNC:RIC3) increases act(complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7))) |
| pubmed:28445721 | p(HGNC:RIC3) increases act(p(FPLX:CHRN)) |
| pubmed:28445721 | p(HGNC:RIC3) increases act(p(FPLX:CHRN)) |
| pubmed:28445721 | p(HGNC:RIC3) increases act(p(FPLX:CHRN)) |
| pubmed:22040696 | act(p(HGNC:RIC3), ma(go:0044183 ! "protein binding involved in protein folding")) increases p(FPLX:CHRN) |
| pubmed:22040696 | p(HGNC:RIC3) increases act(p(FPLX:CHRN)) |
| pubmed:22040696 | act(p(HGNC:RIC3), ma(go:0044183 ! "protein binding involved in protein folding")) increases p(FPLX:CHRN) |
| pubmed:28445721 | p(HGNC:RIC3) causesNoChange complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta2")) |
| pubmed:28445721 | p(HGNC:RIC3) causesNoChange complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:28445721 | p(HGNC:RIC3) increases tloc(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) |
| pubmed:22040696 | p(HGNC:RIC3) regulates bp(GO:"modulation of chemical synaptic transmission") |
| pubmed:22040696 | p(HGNC:RIC3) increases bp(GO:"synaptic transmission, cholinergic") |
| pubmed:22040696 | p(HGNC:RIC3) decreases act(complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4))) |
| pubmed:22040696 | p(HGNC:RIC3) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) |
| pubmed:22040696 | p(HGNC:RIC3) increases p(HGNC:CHRNA9) |
| pubmed:22040696 | p(HGNC:RIC3) increases p(HGNC:CHRNA7) |
| pubmed:22040696 | act(p(HGNC:RIC3), ma(go:0044183 ! "protein binding involved in protein folding")) negativeCorrelation path(MESH:"Bipolar Disorder") |
| pubmed:22040696 | act(p(HGNC:RIC3), ma(go:0044183 ! "protein binding involved in protein folding")) negativeCorrelation path(MESH:"Psychotic Disorders") |
| pubmed:26472524 | tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases bp(GO:"membrane depolarization") |
| pubmed:26472524 | a(MESH:"Cations, Divalent") decreases act(p(MESH:"Receptors, N-Methyl-D-Aspartate"), ma(GO:"NMDA glutamate receptor activity")) |
| pubmed:17009926 | p(HGNC:CHRNA7, var("p.Leu254Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:17009926 | p(HGNC:CHRNA7, var("p.Leu254Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pubmed:17009926 | p(HGNC:CHRNA7, var("p.Leu255Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:17009926 | p(HGNC:CHRNA7, var("p.Leu255Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pubmed:17009926 | composite(a(CHEBI:acetylcholine), a(CHEBI:ivermectin)) increases act(p(FPLX:CHRN)) |
| pubmed:17009926 | a(CHEBI:ivermectin) regulates act(p(HGNC:CHRNA7)) |
| pubmed:17009926 | composite(a(CHEBI:"1,1-dimethyl-4-phenylpiperazinium iodide"), a(CHEBI:ivermectin)) increases act(p(HGNC:CHRNA7)) |
| pubmed:17009926 | composite(a(CHEBI:5-hydroxyindole), a(CHEBI:acetylcholine)) increases act(p(HGNC:CHRNA7)) |
| pubmed:17009926 | a(CHEBI:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea") regulates act(p(HGNC:CHRNA7)) |
| pubmed:28132910 | a(CHEBI:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea") increases complex(a(GO:membrane), a(PUBCHEM:16068384)) |
| pubmed:28132910 | a(CHEBI:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea") increases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384)) |
| pubmed:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases tloc(a(CHEBI:acetylcholine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases tloc(a(CHEBI:noradrenaline), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases tloc(a(CHEBI:serotonin), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:memory) |
| pubmed:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:memory) |
| pubmed:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:learning) |
| pubmed:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases path(MESH:Attention) |
| pubmed:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:cognition) |
| pubmed:19323834 | a(CHEBI:noradrenaline) increases p(HGNC:SUMO1) |
| pubmed:30027901 | a(CHEBI:serotonin) association a(MESH:"Hydroxyindoleacetic Acid") |
| pubmed:17009926 | a(CHEBI:tetrodotoxin) decreases act(complex(GO:"voltage-gated calcium channel complex")) |
| pubmed:17009926 | bp(GO:"regulation of action potential firing rate") association p(FPLX:CHRN) |
| pubmed:17009926 | act(complex(GO:"GABA-A receptor complex")) increases bp(GO:"membrane depolarization") |
| pubmed:17009926 | bp(GO:"regulation of action potential firing pattern") association p(FPLX:CHRN) |
| pubmed:17009926 | bp(GO:"action potential") increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:17009926 | bp(GO:"response to pain") association p(FPLX:CHRN) |
| pubmed:17009926 | a(PUBCHEM:5311278) decreases act(p(HGNC:CHRNA7)) |
| pubmed:17009926 | a(PUBCHEM:5311278) decreases bp(GO:memory) |
| pubmed:25514383 | a(PUBCHEM:5311278) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:26813123 | p(FPLX:CHRM) isA a(MESH:"Receptors, G-Protein-Coupled") |
| pubmed:26813123 | p(FPLX:CHRM) regulates a(MESH:"Ion Channels") |
| pubmed:26813123 | p(FPLX:CHRM) regulates act(a(MESH:"Calcium Channels")) |
| pubmed:26813123 | p(FPLX:CHRM) regulates act(a(MESH:"Potassium Channels")) |
| pubmed:26813123 | act(p(FPLX:CHRM)) decreases act(a(MESH:"Potassium Channels")) |
| pubmed:26813123 | p(FPLX:CHRM) regulates act(a(MESH:"Chloride Channels")) |
| pubmed:26813123 | act(p(FPLX:CHRM)) decreases bp(GO:"synaptic transmission, glutamatergic") |
| pubmed:25514383 | p(FPLX:CHRM) regulates bp(GO:cognition) |
| pubmed:17009926 | p(HGNC:CHRNA4, var("p.Ser248Thr")) increases path(MESH:Epilepsy) |
| pubmed:17009926 | g(HGNC:CHRNA4, var("?")) positiveCorrelation path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") |
| pubmed:17009926 | path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") positiveCorrelation g(HGNC:CHRNA4, var("?")) |
| pubmed:17009926 | path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") positiveCorrelation g(HGNC:CHRNB2, var("?")) |
| pubmed:17009926 | g(HGNC:CHRNB2, var("?")) positiveCorrelation path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") |
| pubmed:28445721 | path(MESH:Arousal) association p(FPLX:CHRN) |
| pubmed:28901280 | path(MESH:Arousal) association p(MESH:"Receptors, Nicotinic") |
| pubmed:26472524 | composite(a(CHEBI:nicotine), p(HGNC:CHRNB2)) increases complex(a(CHEBI:nicotine), p(HGNC:CHRNB2)) |
| pubmed:23702978 | a(CHEBI:"potassium(1+)") decreases bp(GO:"apoptosome assembly") |
| pubmed:23702978 | a(CHEBI:"potassium(1+)") increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pubmed:23702978 | a(CHEBI:"potassium(1+)") increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:23702978 | a(CHEBI:"potassium(1+)") increases act(p(HGNC:PYCARD)) |
| pubmed:23702978 | a(CHEBI:"potassium(1+)") decreases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:24561250 | a(CHEBI:"potassium(1+)") increases act(complex(GO:"inflammasome complex")) |
| pubmed:26472524 | act(p(MESH:"Receptors, N-Methyl-D-Aspartate")) increases bp(GO:"long-term synaptic potentiation") |
| pubmed:26751493 | p(MESH:"Receptors, N-Methyl-D-Aspartate") association p(CONSO:"projection domain") |
| pubmed:16820021 | a(CONSO:"SK and F 77434") decreases a(MESH:"8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol") |
| pubmed:16820021 | a(MESH:antalarmin) causesNoChange act(p(RGD:Drd1)) |
| pubmed:16820021 | a(MESH:antalarmin) increases p(RGD:Drd2) |
| pubmed:16820021 | a(MESH:antalarmin) decreases p(RGD:Drd2) |
| pubmed:16820021 | a(MESH:antalarmin) increases p(RGD:Drd3) |
| pubmed:16820021 | a(MESH:antalarmin) decreases p(RGD:Drd3) |
| pubmed:16820021 | a(MESH:antalarmin) decreases path(CONSO:"isolation rearing") |
| pubmed:16820021 | a(MESH:antalarmin) causesNoChange path(CONSO:"isolation rearing") |
| pubmed:16820021 | a(MESH:antalarmin) causesNoChange path(CONSO:"isolation rearing") |
| pubmed:16820021 | a(MESH:antalarmin) causesNoChange r(RGD:Bdnf) |
| pubmed:16820021 | a(MESH:antalarmin) causesNoChange p(RGD:Ntrk2) |
| pubmed:16820021 | a(MESH:antalarmin) decreases r(RGD:Ntrk2) |
| pubmed:16820021 | a(MESH:antalarmin) increases r(RGD:Ntrk2) |
| pubmed:29807032 | a(MESH:antalarmin) decreases bp(MESH:"Heat-Shock Response") |
| pubmed:29807032 | a(MESH:antalarmin) increases act(p(NCBIGENE:140621)) |
| pubmed:29807032 | a(MESH:antalarmin) causesNoChange a(MESH:"Embryonic Structures") |
| pubmed:29807032 | a(MESH:antalarmin) causesNoChange a(MESH:"Embryonic Structures") |
| pubmed:23211705 | a(MESH:antalarmin) increases a(MESH:"Embryonic Structures") |
| pubmed:23211705 | a(MESH:antalarmin) increases a(MESH:Morula) |
| pubmed:23211705 | a(MESH:antalarmin) increases a(MESH:Blastocyst) |
| pubmed:23211705 | a(MESH:antalarmin) decreases act(p(MGI:Crhr1)) |
| pubmed:23211705 | a(MESH:antalarmin) decreases act(p(MGI:Crhr1)) |
| pubmed:23211705 | a(MESH:antalarmin) decreases act(p(MGI:Crh)) |
| pubmed:16820021 | composite(complex(a(CONSO:"[125I]-NCQ 298"), p(RGD:Drd1)), p(MESH:Raclopride)) increases complex(p(MESH:Raclopride), p(RGD:Drd1)) |
| pubmed:16820021 | path(CONSO:"isolation rearing") increases p(RGD:Drd2) |
| pubmed:16820021 | path(CONSO:"isolation rearing") increases p(RGD:Drd2) |
| pubmed:16820021 | path(CONSO:"isolation rearing") increases p(RGD:Drd3) |
| pubmed:16820021 | path(CONSO:"isolation rearing") increases p(RGD:Drd3) |
| pubmed:16820021 | path(CONSO:"isolation rearing") decreases r(RGD:Bdnf) |
| pubmed:16820021 | path(CONSO:"isolation rearing") increases r(RGD:Bdnf) |
| pubmed:16820021 | path(CONSO:"isolation rearing") regulates p(RGD:Bdnf) |
| pubmed:16820021 | path(CONSO:"isolation rearing") decreases r(RGD:Ntrk2) |
| pubmed:16820021 | path(CONSO:"isolation rearing") increases r(RGD:Ntrk2) |
| pubmed:16820021 | path(CONSO:"isolation rearing") regulates p(RGD:Ntrk2) |
| pubmed:22530628 | path(MESH:"Memory Disorders") positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:22530628 | path(MESH:"Memory Disorders") negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:18986241 | path(MESH:"Memory Disorders") association path(CONSO:aMCI) |
| pubmed:22530628 | path(MESH:"Tobacco Use") negativeCorrelation path(DOID:"Alzheimer's disease") |
| pubmed:21482353 | path(MESH:"Tobacco Use") decreases path(MESH:"Parkinson Disease") |
| pubmed:22530628 | complex(a(CHEBI:amyloid-beta), a(CHEBI:nicotine)) decreases a(CONSO:"amyloid-beta aggregates") |
| pubmed:22530628 | complex(a(CHEBI:amyloid-beta), a(CHEBI:nicotine)) decreases a(CONSO:"amyloid-beta fibrils") |
| pubmed:22530628 | complex(a(CHEBI:amyloid-beta), a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection) |
| pubmed:22530628 | a(MESH:Cotinine) decreases path(MESH:"Memory Disorders") |
| pubmed:22530628 | a(MESH:Cotinine) decreases a(CONSO:"amyloid-beta aggregates") |
| pubmed:22530628 | a(MESH:Cotinine) decreases a(CONSO:"amyloid-beta aggregates") |
| pubmed:22530628 | a(MESH:Cotinine) decreases a(CONSO:"amyloid-beta aggregates") |
| pubmed:22530628 | a(MESH:Cotinine) decreases path(MESH:"Plaque, Amyloid") |
| pubmed:22530628 | a(MESH:Cotinine) decreases path(MESH:"Plaque, Amyloid") |
| pubmed:22530628 | a(MESH:Cotinine) increases a(PUBCHEM:10219774) |
| pubmed:22530628 | a(MESH:Cotinine) increases a(MESH:"cotinine N-glucuronide") |
| pubmed:22530628 | a(MESH:Cotinine) increases bp(GO:"learning or memory") |
| pubmed:22530628 | a(MESH:Cotinine) decreases path(HP:Anxiety) |
| pubmed:22530628 | a(MESH:Cotinine) decreases path(MESH:Fear) |
| pubmed:22530628 | a(MESH:Cotinine) increases bp(GO:cognition) |
| pubmed:22530628 | a(MESH:Cotinine) decreases a(CONSO:"amyloid-beta oligomers") |
| pubmed:22530628 | a(MESH:Cotinine) increases act(p(HGNC:AKT1)) |
| pubmed:22530628 | a(MESH:Cotinine) increases act(p(HGNC:AKT1)) |
| pubmed:22530628 | a(MESH:Cotinine) increases act(p(HGNC:GSK3B)) |
| pubmed:22530628 | a(MESH:Cotinine) increases act(p(HGNC:GSK3B)) |
| pubmed:22530628 | a(MESH:Cotinine) decreases p(HGNC:GSK3B) |
| pubmed:22530628 | a(MESH:Cotinine) increases p(HGNC:CHRNA7) |
| pubmed:22530628 | a(MESH:Cotinine) increases act(p(HGNC:CHRNA7)) |
| pubmed:22530628 | a(MESH:Cotinine) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22530628 | a(MESH:Cotinine) decreases p(MESH:"Neurofibrillary Tangles") |
| pubmed:22530628 | a(MESH:Cotinine) increases act(p(HGNC:CREBBP)) |
| pubmed:22530628 | a(MESH:Cotinine) increases act(p(HGNC:MAPK3)) |
| pubmed:22530628 | a(MESH:Cotinine) increases act(p(HGNC:MAPK1)) |
| pubmed:22530628 | composite(a(CHEBI:nicotine), p(HGNC:CYP2A6)) increases a(MESH:Cotinine) |
| pubmed:22530628 | composite(a(CHEBI:nicotine), p(NCIT:C18024)) increases a(MESH:Cotinine) |
| pubmed:21482353 | path(MESH:Fear) increases a(CHEBI:dopamine) |
| pubmed:29428175 | bp(MESH:"Long-Term Potentiation") positiveCorrelation bp(GO:"glutamate secretion") |
| pubmed:27796283 | bp(MESH:"Long-Term Potentiation") association p(HGNC:CAMKV) |
| pubmed:22530628 | complex(CONSO:"alpha-4 beta-2 nAChR") increases bp(GO:"learning or memory") |
| pubmed:22530628 | complex(CONSO:"alpha-4 beta-2 nAChR") increases path(MESH:Attention) |
| pubmed:22530628 | complex(CONSO:"alpha-4 beta-2 nAChR") increases bp(GO:cognition) |
| pubmed:24762290 | complex(CONSO:"alpha-4 beta-2 nAChR") association a(MESH:Thalamus) |
| pubmed:24762290 | complex(CONSO:"alpha-4 beta-2 nAChR") association a(MESH:Thalamus) |
| pubmed:24762290 | complex(CONSO:"alpha-4 beta-2 nAChR") association a(MESH:Pons) |
| pubmed:24762290 | complex(CONSO:"alpha-4 beta-2 nAChR") association a(MESH:Mesencephalon) |
| pubmed:24762290 | complex(CONSO:"alpha-4 beta-2 nAChR") association a(MESH:"Corpus Striatum") |
| pubmed:24762290 | complex(CONSO:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"White Matter") |
| pubmed:24762290 | complex(CONSO:"alpha-4 beta-2 nAChR") association path(MESH:"Parkinson Disease") |
| pubmed:24762290 | complex(CONSO:"alpha-4 beta-2 nAChR") association a(MESH:"Parietal Lobe") |
| pubmed:24762290 | complex(CONSO:"alpha-4 beta-2 nAChR") association path(MESH:Memory) |
| pubmed:19721446 | bp(MESH:"Sensory Gating") association path(MESH:Schizophrenia) |
| pubmed:19721446 | bp(MESH:"Sensory Gating") association p(HGNC:CHRNA7) |
| pubmed:22530628 | a(DRUGBANK:GTS-21) increases bp(GO:cognition) |
| pubmed:22530628 | a(MESH:"3-(4-dimethylaminobenzylidene)anabaseine") increases bp(GO:cognition) |
| pubmed:22530628 | p(HGNC:DBF4) decreases p(HGNC:MAP3K5) |
| pubmed:22530628 | p(HGNC:PIK3CA) increases bp(MESH:"Neuronal Plasticity") |
| pubmed:22530628 | p(HGNC:PIK3CA) increases bp(GO:cognition) |
| pubmed:22530628 | p(HGNC:PIK3CA) increases bp(GO:"learning or memory") |
| pubmed:22530628 | p(HGNC:PIK3CA) increases p(HGNC:AKT1, pmod(go:0006468 ! "protein phosphorylation", Thr, 308)) |
| pubmed:22530628 | p(HGNC:PIK3CA) increases p(HGNC:AKT1, pmod(go:0006468 ! "protein phosphorylation", Ser, 473)) |
| pubmed:30697142 | p(HGNC:PIK3CA) increases p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:18467332 | p(HGNC:PIK3R1) isA complex(p(HGNC:MAPT), p(HGNC:PIK3R1)) |
| pubmed:22530628 | complex(p(HGNC:FYN), p(HGNC:PIK3R1)) increases act(p(HGNC:PIK3CA)) |
| pubmed:22530628 | act(p(HGNC:AKT1, pmod(go:0006468 ! "protein phosphorylation", Thr, 308))) increases act(p(HGNC:BCL2)) |
| pubmed:22530628 | act(p(HGNC:AKT1, pmod(go:0006468 ! "protein phosphorylation", Thr, 308))) increases act(p(HGNC:CREBBP)) |
| pubmed:22530628 | act(p(HGNC:AKT1, pmod(go:0006468 ! "protein phosphorylation", Thr, 308))) increases p(HGNC:MAP3K5, pmod(go:0006468 ! "protein phosphorylation", Ser, 83)) |
| pubmed:22530628 | act(p(HGNC:AKT1, pmod(go:0006468 ! "protein phosphorylation", Thr, 308))) decreases act(p(HGNC:MAP3K5)) |
| pubmed:22530628 | act(p(HGNC:AKT1, pmod(go:0006468 ! "protein phosphorylation", Ser, 473))) increases act(p(HGNC:BCL2)) |
| pubmed:22530628 | act(p(HGNC:AKT1, pmod(go:0006468 ! "protein phosphorylation", Ser, 473))) increases act(p(HGNC:CREBBP)) |
| pubmed:22530628 | act(p(HGNC:AKT1, pmod(go:0006468 ! "protein phosphorylation", Ser, 473))) increases p(HGNC:MAP3K5, pmod(go:0006468 ! "protein phosphorylation", Ser, 83)) |
| pubmed:22530628 | act(p(HGNC:AKT1, pmod(go:0006468 ! "protein phosphorylation", Ser, 473))) decreases act(p(HGNC:MAP3K5)) |
| pubmed:22530628 | p(HGNC:MAP3K5, pmod(go:0006468 ! "protein phosphorylation", Ser, 83)) decreases act(p(HGNC:MAP3K5)) |
| pubmed:22530628 | p(HGNC:ARC) increases bp(GO:"learning or memory") |
| pubmed:22530628 | p(HGNC:ARC) increases bp(MESH:"Neuronal Plasticity") |
| pubmed:22908190 | p(HGNC:ARC) regulates bp(GO:"synapse maturation") |
| pubmed:22530628 | p(HGNC:ACR) increases bp(GO:"learning or memory") |
| pubmed:22530628 | bp(MESH:"Serum Response Element") increases p(HGNC:ARC) |
| pubmed:22530628 | p(HGNC:EEF2) increases p(HGNC:ARC) |
| pubmed:22530628 | r(HGNC:ARC) positiveCorrelation p(HGNC:CHRNA7) |
| pubmed:22530628 | a(DRUGBANK:"1-Anilino-8-Naphthalene Sulfonate") causesNoChange a(CONSO:"amyloid-beta oligomers") |
| pubmed:22530628 | a(DRUGBANK:"1-Anilino-8-Naphthalene Sulfonate") decreases a(CONSO:"amyloid-beta fibrils") |
| pubmed:26813123 | bp(GO:"response to stress") association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:26813123 | bp(GO:"response to stress") regulates tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(MESH:"Basal Forebrain")) |
| pubmed:24563850 | bp(GO:"response to stress") increases p(HGNCGENEFAMILY:"Small heat shock proteins") |
| pubmed:24563850 | bp(GO:"response to stress") increases p(HGNC:HSF1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24563850 | bp(GO:"response to stress") increases complex(p(HGNC:HSF1), p(HGNC:HSF1), p(HGNC:HSF1)) |
| pubmed:24563850 | bp(GO:"response to stress") increases p(HGNC:HSF1, loc(MESH:"Cell Nucleus")) |
| pubmed:24563850 | bp(GO:"response to stress") increases act(p(HGNC:HSF1), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:27181519 | bp(GO:"response to stress") increases p(HGNC:HDAC6, loc(GO:"cytoplasmic stress granule")) |
| pubmed:30988501 | bp(GO:"response to stress") increases act(complex(MESH:Inflammasomes)) |
| pubmed:30988501 | bp(GO:"response to stress") increases path(MESH:Recurrence) |
| pubmed:26813123 | bp(GO:"regulation of circadian sleep/wake cycle, wakefulness") association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:26813123 | bp(GO:"regulation of circadian sleep/wake cycle, sleep") association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:24590577 | bp(GO:"circadian sleep/wake cycle") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pubmed:26813123 | p(HGNC:SLC18A3) increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:cytosol), toLoc(MESH:"Synaptic Vesicles")) |
| pubmed:26813123 | p(HGNC:SLC18A3) increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:cytosol), toLoc(MESH:"Synaptic Vesicles")) |
| pubmed:26813123 | p(HGNC:SLC18A3) increases tloc(a(CHEBI:proton), fromLoc(MESH:"Synaptic Vesicles"), toLoc(GO:cytosol)) |
| pubmed:26813123 | p(HGNC:CHAT, pmod(go:0006468 ! "protein phosphorylation")) regulates act(p(HGNC:CHAT)) |
| pubmed:26813123 | a(CHEBI:"2-(4-phenyl-1-piperidinyl)-1-cyclohexanol") decreases act(p(HGNC:SLC18A3)) |
| pubmed:26813123 | a(CHEBI:"2-(4-phenyl-1-piperidinyl)-1-cyclohexanol") decreases tloc(a(CHEBI:acetylcholine), fromLoc(GO:cytosol), toLoc(MESH:"Synaptic Vesicles")) |
| pubmed:26813123 | p(MGI:Slc18a3) decreases path(MESH:"Neuromuscular Diseases") |
| pubmed:26813123 | p(MGI:Slc18a3) increases bp(GO:cognition) |
| pubmed:26813123 | a(CHEBI:"organophosphorus compound") decreases act(p(HGNC:ACHE)) |
| pubmed:26813123 | a(CHEBI:antidote) increases act(p(HGNC:ACHE)) |
| pubmed:26813123 | a(CHEBI:doxylamine) increases act(p(HGNC:ACHE)) |
| pubmed:26813123 | a(CHEBI:succinylcholine) decreases act(p(HGNC:ACHE)) |
| pubmed:26813123 | p(MGI:Slc5a7) decreases path(MESH:Death) |
| pubmed:26813123 | complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) association bp(GO:"action potential initiation") |
| pubmed:26813123 | a(MESH:"Basal Nucleus of Meynert") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26813123 | p(FPLX:CHRN, pmod(go:0006468 ! "protein phosphorylation")) regulates act(p(FPLX:CHRN)) |
| pubmed:26813123 | a(MESH:"Protein-Tyrosine Kinases") increases p(FPLX:CHRN, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26813123 | complex(a(CHEBI:"1,1-dimethyl-4-phenylpiperazinium iodide"), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) |
| pubmed:26813123 | complex(a(CHEBI:cystine), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) |
| pubmed:22020111 | a(CHEBI:cystine) increases a(CHEBI:glutathione) |
| pubmed:26813123 | complex(a(CHEBI:nicotine), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) |
| pubmed:11230871 | complex(a(CHEBI:nicotine), p(FPLX:CHRN)) association bp(GO:cognition) |
| pubmed:26813123 | a(CHEBI:tubocurarine) decreases act(p(FPLX:CHRN)) |
| pubmed:29626319 | a(MESH:"Receptors, G-Protein-Coupled") increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:26813123 | complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC)) |
| pubmed:26813123 | complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:myo-inositol) |
| pubmed:26813123 | complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) |
| pubmed:26813123 | complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") |
| pubmed:26813123 | complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26813123 | complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases bp(GO:cognition) |
| pubmed:26813123 | complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC)) |
| pubmed:26813123 | complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:myo-inositol) |
| pubmed:26813123 | complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) |
| pubmed:26813123 | complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") |
| pubmed:26813123 | complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC)) |
| pubmed:26813123 | complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:myo-inositol) |
| pubmed:26813123 | complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) |
| pubmed:26813123 | complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") |
| pubmed:26813123 | complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases p(FPLX:ADCY) |
| pubmed:26813123 | complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases a(CHEBI:"3',5'-cyclic AMP") |
| pubmed:26813123 | complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases act(a(MESH:"Calcium Channels")) |
| pubmed:26813123 | complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases p(FPLX:ADCY) |
| pubmed:26813123 | complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases a(CHEBI:"3',5'-cyclic AMP") |
| pubmed:26813123 | complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases act(a(MESH:"Calcium Channels")) |
| pubmed:26088141 | act(a(MESH:"Calcium Channels")) association act(a(CHEBI:choline)) |
| pubmed:26088141 | act(a(MESH:"Calcium Channels")) association a(CHEBI:"calcium(2+)") |
| pubmed:26813123 | complex(a(CHEBI:Muscarine), p(FPLX:CHRM)) increases act(p(FPLX:CHRM)) |
| pubmed:26813123 | a(MESH:"Quinuclidinyl Benzilate") decreases act(p(FPLX:CHRM)) |
| pubmed:26813123 | a(MESH:"Receptors, Cholinergic") increases bp(GO:memory) |
| pubmed:25514383 | a(MESH:"Receptors, Cholinergic") increases path(MESH:Attention) |
| pubmed:26813123 | path(MESH:Apathy) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26813123 | p(MGI:Chrm4) decreases tloc(a(CHEBI:dopamine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pubmed:24590577 | p(MGI:Chrm4) decreases act(a(CHEBI:phencyclidine)) |
| pubmed:24590577 | p(MGI:Chrm4) decreases bp(GO:"locomotor rhythm") |
| pubmed:24590577 | p(MGI:Chrm4) decreases act(p(MGI:Drd1)) |
| pubmed:26813123 | path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation a(MESH:"Cholinergic Neurons") |
| pubmed:22020111 | path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation a(CONSO:"protein aggregates") |
| pubmed:30688256 | path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation bp(GO:mitophagy) |
| pubmed:30688256 | path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation act(p(HGNCGENEFAMILY:"Miro like atypical Rho GTPases")) |
| pubmed:30688256 | path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation p(HGNC:RHOT1) |
| pubmed:30688256 | path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation a(PUBCHEM:124886) |
| pubmed:30688256 | path(MESH:"Amyotrophic Lateral Sclerosis") association a(CHEBI:"reactive oxygen species") |
| pubmed:12428809 | path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation a(MESH:"Intermediate Filaments") |
| pubmed:21722302 | path(MESH:"Amyotrophic Lateral Sclerosis") association path(CONSO:Neurodegeneration) |
| pubmed:21722302 | path(MESH:"Amyotrophic Lateral Sclerosis") association path(CONSO:Neurodegeneration) |
| pubmed:21722302 | path(MESH:"Amyotrophic Lateral Sclerosis") association a(CONSO:"Motor Neurons") |
| pubmed:21722302 | path(MESH:"Amyotrophic Lateral Sclerosis") increases bp(CONSO:"protein aggregation") |
| pubmed:21722302 | path(MESH:"Amyotrophic Lateral Sclerosis") association a(GO:"Bunina body") |
| pubmed:21722302 | path(MESH:"Amyotrophic Lateral Sclerosis") association a(GO:"neurofilament cytoskeleton") |
| pubmed:21722302 | path(MESH:"Amyotrophic Lateral Sclerosis") association a(CHEBI:ubiquitin) |
| pubmed:21722302 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SOD1, var("?")) |
| pubmed:21722302 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SOD1, var("?")) |
| pubmed:14556719 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SOD1, var("?")) |
| pubmed:21722302 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNCGENEFAMILY:"Protein disulfide isomerases") |
| pubmed:21722302 | path(MESH:"Amyotrophic Lateral Sclerosis") association bp(GO:"ERAD pathway") |
| pubmed:21722302 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:VAPB, var("?")) |
| pubmed:21722302 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:TARDBP) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation act(p(HGNC:TARDBP, loc(GO:nucleus))) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, loc(GO:"inclusion body")) |
| pubmed:21722302 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:ERN1) |
| pubmed:21722302 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:EIF2AK3) |
| pubmed:21722302 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:ATF6) |
| pubmed:25784053 | path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation p(HGNC:ATF6) |
| pubmed:30740335 | path(MESH:"Amyotrophic Lateral Sclerosis") increases deg(p(MESH:"Motor Neurons")) |
| pubmed:29758300 | path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP, pmod(CONSO:misfolding)) |
| pubmed:29758300 | path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation bp(GO:macroautophagy) |
| pubmed:14556719 | path(MESH:"Amyotrophic Lateral Sclerosis") decreases a(MESH:"Brain Stem") |
| pubmed:14556719 | path(MESH:"Amyotrophic Lateral Sclerosis") decreases bp(GO:"spinal cord development") |
| pubmed:14556719 | path(MESH:"Amyotrophic Lateral Sclerosis") decreases a(MESH:"Pyramidal Tracts") |
| pubmed:14556719 | path(MESH:"Amyotrophic Lateral Sclerosis") increases path(MESH:Paralysis) |
| pubmed:14556719 | path(MESH:"Amyotrophic Lateral Sclerosis") increases bp(GO:"neuron death") |
| pubmed:14556719 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:RNF19A) |
| pubmed:14556719 | path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:UBL5) |
| pubmed:22908190 | path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:22908190 | path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:25784053 | path(MESH:"Amyotrophic Lateral Sclerosis") increases bp(GO:autophagy) |
| pubmed:26702100 | path(MESH:"Amyotrophic Lateral Sclerosis") association bp(GO:autophagy) |
| pubmed:30116051 | path(MESH:"Amyotrophic Lateral Sclerosis") association path(MESH:"Frontotemporal Dementia") |
| pubmed:30116051 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SQSTM1) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SQSTM1, loc(GO:"inclusion body")) |
| pubmed:30116051 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:CHMP2B) |
| pubmed:30116051 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:TBK1) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:TBK1) |
| pubmed:30116051 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:OPTN) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:OPTN) |
| pubmed:29980653 | path(MESH:"Amyotrophic Lateral Sclerosis") isA path(MESH:"Neurodegenerative Diseases") |
| pubmed:29980653 | path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP, var("?")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("?")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SOD1) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:FUS) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:C9orf72) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:ATXN2) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:VCP) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:PFN1) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:UBQLN2) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:UBQLN4) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:NEK1) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:MATR3) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:CHCHD10) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SETX) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:KIF5A) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, frag("1_102")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, frag("336_414")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Ala382Thr")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Met337Val")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:TARDBP, var("p.Met337Val")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Ala315Thr")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Gln331Lys")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:TARDBP, var("p.Gln331Lys")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Asp169Gly")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Gly294Ala")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Gly294Val")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Gln343Arg")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Ala90Val")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Asn267Ser")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Gly348Cys")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Ala328Thr")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Ser393Leu")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Gly295Ser")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, frag("274_414"), pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association path(MESH:Oxidation-Reduction) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association path(MESH:"Oxidative Stress") |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association bp(GO:"peptidyl-cysteine oxidation") |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, pmod(GO:"protein complex oligomerization")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:TARDBP, var("p.Ala321Gly")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:MAP1LC3A, loc(GO:"inclusion body")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:UBQLN2, var("?")) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation path(MESH:Endocytosis) |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association a(CHEBI:"iron(3+)") |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association path(MESH:"Chromatin Assembly and Disassembly") |
| pubmed:30837838 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:TARDBP, var("Met337Val")) |
| pubmed:26813123 | path(MESH:"Supranuclear Palsy, Progressive") negativeCorrelation a(MESH:"Cholinergic Neurons") |
| pubmed:29758300 | path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT) |
| pubmed:30126037 | path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT) |
| pubmed:30126037 | path(MESH:"Supranuclear Palsy, Progressive") increases p(CONSO:CONSO00045) |
| pubmed:30126037 | path(MESH:"Supranuclear Palsy, Progressive") increases a(GO:"neurofibrillary tangle") |
| pubmed:11089576 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation a(GO:"neurofibrillary tangle") |
| pubmed:30126037 | path(MESH:"Supranuclear Palsy, Progressive") increases bp(HP:Neurodegeneration) |
| pubmed:30126037 | path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:Gliosis) |
| pubmed:30126037 | path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:"Motor Disorders") |
| pubmed:30126037 | path(MESH:"Supranuclear Palsy, Progressive") association path(MESH:"Parkinsonian Disorders") |
| pubmed:30126037 | path(MESH:"Supranuclear Palsy, Progressive") association path(MESH:Tauopathies) |
| pubmed:29311797 | path(MESH:"Supranuclear Palsy, Progressive") isA path(MESH:Tauopathies) |
| pubmed:26631930 | path(MESH:"Supranuclear Palsy, Progressive") isA path(MESH:Tauopathies) |
| pubmed:30126037 | path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:"Cognitive Dysfunction") |
| pubmed:30126037 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:CDKN2A) |
| pubmed:29191965 | path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT, var("p.Ala152Thr")) |
| pubmed:26631930 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:MAPT, var("p.Ala152Thr")) |
| pubmed:28420982 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation a(CONSO:"Tau oligomers") |
| pubmed:26631930 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation a(CONSO:"Tau oligomers") |
| pubmed:26751493 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(CONSO:"4R tau") |
| pubmed:26631930 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(CONSO:"4R tau") |
| pubmed:26631930 | path(MESH:"Supranuclear Palsy, Progressive") negativeCorrelation m(HGNC:MIR132) |
| pubmed:26631930 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:SRSF2) |
| pubmed:26631930 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:12578227 | path(MESH:"Supranuclear Palsy, Progressive") increases p(HGNC:TGM1) |
| pubmed:12578227 | path(MESH:"Supranuclear Palsy, Progressive") increases r(HGNC:TGM1) |
| pubmed:12578227 | path(MESH:"Supranuclear Palsy, Progressive") increases p(CONSO:"TGM2 Isoform 3 (349 aa)") |
| pubmed:12578227 | path(MESH:"Supranuclear Palsy, Progressive") increases r(HGNC:TGM2) |
| pubmed:11089576 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation act(p(ECCODE:2.3.2.13)) |
| pubmed:22057784 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) |
| pubmed:17050703 | path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) |
| pubmed:29281045 | path(MESH:"Supranuclear Palsy, Progressive") decreases p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) |
| pubmed:29281045 | path(MESH:"Supranuclear Palsy, Progressive") decreases p(HGNC:LCMT1) |
| pubmed:29281045 | path(MESH:"Supranuclear Palsy, Progressive") increases p(HGNC:PPME1) |
| pubmed:30837838 | path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) |
| pubmed:30837838 | path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) |
| pubmed:26813123 | path(MESH:"Olivopontocerebellar Atrophies") negativeCorrelation a(MESH:"Cholinergic Neurons") |
| pubmed:26813123 | act(a(GO:"cholinergic synapse")) association a(CONSO:"amyloid-beta oligomers") |
| pubmed:26813123 | complex(a(MESH:"Amyloid beta-Peptides"), p(HGNC:ACHE)) increases a(CONSO:"amyloid-beta fibrils") |
| pubmed:26813123 | p(MGI:App, var("?")) decreases tloc(a(CHEBI:choline), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:26813123 | p(MGI:App, var("?")) decreases p(FPLX:CHRM) |
| pubmed:26813123 | p(MGI:App, var("?")) decreases p(FPLX:CHRN) |
| pubmed:22419736 | p(MGI:App, var("?")) increases p(MGI:Ak1) |
| pubmed:26813123 | a(PUBCHEM:10013505) increases act(p(HGNC:CHRM1)) |
| pubmed:26813123 | a(PUBCHEM:10013505) increases bp(GO:cognition) |
| pubmed:26813123 | a(PUBCHEM:10013505) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:26813123 | a(PUBCHEM:10013505) decreases p(HGNC:MAPT, var("?")) |
| pubmed:26813123 | a(PUBCHEM:10013505) increases a(MESH:"Amyloid Precursor Protein Secretases") |
| pubmed:24653673 | p(HGNC:MAPT, var("?")) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:MAPT)) |
| pubmed:22299660 | p(HGNC:MAPT, var("?")) association path(MESH:"Frontotemporal Dementia") |
| pubmed:30116051 | p(HGNC:MAPT, var("?")) decreases act(complex(GO:"proteasome complex")) |
| pubmed:30116051 | p(HGNC:MAPT, var("?")) decreases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) |
| pubmed:30116051 | p(HGNC:MAPT, var("?")) decreases deg(a(CONSO:"Tau oligomers")) |
| pubmed:30116051 | p(HGNC:MAPT, var("?")) decreases bp(GO:"chaperone-mediated autophagy") |
| pubmed:29215007 | p(HGNC:MAPT, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29980653 | p(HGNC:MAPT, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21734277 | p(HGNC:MAPT, var("?")) increases p(CONSO:"phosphatase-activating domain") |
| pubmed:29988016 | act(p(HGNC:MAPT, var("?"))) increases a(CONSO:"Tau aggregates") |
| pubmed:29988016 | act(p(HGNC:MAPT, var("?"))) increases a(CONSO:"Tau aggregates") |
| pubmed:21882945 | p(HGNC:MAPT, var("?")) increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, var("?")) increases a(CONSO:"Tau aggregates") |
| pubmed:21882945 | p(HGNC:MAPT, var("?")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:21882945 | p(HGNC:MAPT, var("?")) association bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") |
| pubmed:26631930 | p(HGNC:MAPT, var("?")) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) |
| pubmed:26631930 | p(HGNC:MAPT, var("?")) decreases act(a(GO:synapse)) |
| pubmed:29980653 | p(HGNC:MAPT, var("?")) positiveCorrelation path(MESH:Tauopathies) |
| pubmed:26813123 | a(PUBCHEM:9867750) increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pubmed:26813123 | a(PUBCHEM:9867750) increases act(p(HGNC:CHRM1)) |
| pubmed:26813123 | a(PUBCHEM:9867750) increases act(a(MESH:"Receptors, Nicotinic")) |
| pubmed:26813123 | a(PUBCHEM:9867750) increases bp(GO:cognition) |
| pubmed:29724491 | path(MESH:"Mood Disorders") association p(HGNC:ADNP, var("?")) |
| pubmed:30988501 | path(MESH:"Mood Disorders") association bp(MESH:"Immunity, Cellular") |
| pubmed:26813123 | a(PUBCHEM:1476756) increases bp(GO:"excitatory postsynaptic potential") |
| pubmed:26813123 | a(PUBCHEM:1476756) increases bp(GO:memory) |
| pubmed:26813123 | a(MESH:"Nerve Growth Factor") increases a(MESH:"Cholinergic Neurons") |
| pubmed:26813123 | a(MESH:"Nerve Growth Factor") increases a(MESH:"Cholinergic Neurons") |
| pubmed:26813123 | a(MESH:"Nerve Growth Factor") increases bp(GO:memory) |
| pubmed:11230871 | a(MESH:"Nerve Growth Factor") increases complex(a(CHEBI:nicotine), p(FPLX:CHRN)) |
| pubmed:31248781 | composite(complex(CONSO:gamma-secretase), p(HGNC:APP), p(HGNC:BACE1)) increases p(HGNC:APP, frag("?")) |
| pubmed:31248781 | p(HGNC:APP, frag("?")) increases a(CHEBI:amyloid-beta) |
| pubmed:23516100 | p(HGNC:APP, frag("?")) increases complex(MESH:"Neurofibrillary Tangles") |
| pubmed:23516100 | p(HGNC:APP, frag("?")) increases path(MESH:"Plaque, Amyloid") |
| pubmed:31248781 | complex(GO:"neurotransmitter receptor complex") association bp(MESH:Neuroprotection) |
| pubmed:31248781 | act(p(MESH:Caspases)) negativeCorrelation bp(MESH:Neuroprotection) |
| pubmed:23516100 | act(p(MESH:Caspases)) increases p(HGNC:MAPT, frag("?")) |
| pubmed:23516100 | act(p(MESH:Caspases)) increases p(HGNC:MAPT, frag("?")) |
| pubmed:23516100 | act(p(MESH:Caspases)) increases p(HGNC:HTT, frag("?")) |
| pubmed:30837838 | p(MESH:Caspases) increases p(HGNC:TARDBP, frag("?")) |
| pubmed:31248781 | composite(a(CHEBI:amyloid-beta), p(HGNC:GRM5), p(HGNC:PRNP)) decreases bp(GO:"synaptic signaling") |
| pubmed:31248781 | composite(a(CHEBI:amyloid-beta), p(HGNC:GRM5), p(HGNC:PRNP)) decreases bp(GO:"neuronal signal transduction") |
| pubmed:31248781 | composite(a(CHEBI:amyloid-beta), p(HGNC:GRM5), p(HGNC:PRNP)) increases bp(GO:"neuron death") |
| pubmed:31248781 | composite(a(CHEBI:amyloid-beta), p(MESH:"Receptors, Islet Amyloid Polypeptide")) decreases bp(GO:"synaptic signaling") |
| pubmed:31248781 | composite(a(CHEBI:amyloid-beta), p(MESH:"Receptors, Islet Amyloid Polypeptide")) decreases bp(GO:"neuronal signal transduction") |
| pubmed:31248781 | composite(a(CHEBI:amyloid-beta), p(MESH:"Receptors, Islet Amyloid Polypeptide")) increases bp(GO:"neuron death") |
| pubmed:31248781 | p(MESH:"Receptors, Islet Amyloid Polypeptide") regulates a(MESH:"Autonomic Nervous System") |
| pubmed:31248781 | composite(a(CHEBI:amyloid-beta), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) decreases bp(GO:"synaptic signaling") |
| pubmed:31248781 | composite(a(CHEBI:amyloid-beta), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) decreases bp(GO:"neuronal signal transduction") |
| pubmed:31248781 | composite(a(CHEBI:amyloid-beta), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) increases bp(GO:"neuron death") |
| pubmed:31248781 | composite(a(CHEBI:amyloid-beta), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor AMPA type subunits")) decreases bp(GO:"synaptic signaling") |
| pubmed:31248781 | composite(a(CHEBI:amyloid-beta), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor AMPA type subunits")) decreases bp(GO:"neuronal signal transduction") |
| pubmed:31248781 | composite(a(CHEBI:amyloid-beta), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor AMPA type subunits")) increases bp(GO:"neuron death") |
| pubmed:31248781 | composite(a(CHEBI:amyloid-beta), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases bp(GO:"synaptic signaling") |
| pubmed:31248781 | composite(a(CHEBI:amyloid-beta), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases bp(GO:"neuronal signal transduction") |
| pubmed:31248781 | composite(a(CHEBI:amyloid-beta), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"neuron death") |
| pubmed:31248781 | p(HGNC:IAPP) regulates a(CHEBI:glucose) |
| pubmed:31248781 | p(HGNC:IAPP) association path(DOID:"diabetes mellitus") |
| pubmed:31248781 | p(HGNC:IAPP) regulates bp(GO:"negative regulation of type B pancreatic cell development") |
| pubmed:30837838 | p(HGNC:IAPP) association p(HGNC:TARDBP, frag("247_250")) |
| pubmed:30837838 | p(HGNC:IAPP) association p(HGNC:TARDBP, frag("312_316")) |
| pubmed:31248781 | path(DOID:"diabetes mellitus") association p(HGNC:IAPP) |
| pubmed:26979166 | path(DOID:"diabetes mellitus") positiveCorrelation path(MESH:Depression) |
| pubmed:26979166 | path(DOID:"diabetes mellitus") positiveCorrelation path(DOID:"bipolar disorder") |
| pubmed:31248781 | complex(p(HGNC:IAPP), p(MESH:"Receptors, Islet Amyloid Polypeptide")) increases bp(GO:"neuron apoptotic process") |
| pubmed:31248781 | complex(p(CHEBI:amyloid-beta), p(MESH:"Receptors, Islet Amyloid Polypeptide")) increases bp(GO:"neuron apoptotic process") |
| pubmed:31248781 | bp(GO:"neurotrophin signaling pathway") association p(HGNC:CREBBP) |
| pubmed:31248781 | bp(GO:"neurotrophin signaling pathway") association bp(MESH:"Cell Survival") |
| pubmed:31248781 | a(DRUGBANK:Edaravone) decreases path(HP:"Ischemic stroke") |
| pubmed:31248781 | a(DRUGBANK:Edaravone) decreases act(a(CHEBI:amyloid-beta)) |
| pubmed:31248781 | a(DRUGBANK:Edaravone) decreases path(MESH:"Oxidative Stress") |
| pubmed:31248781 | a(DRUGBANK:Edaravone) decreases path(CONSO:"APP processing") |
| pubmed:31248781 | a(DRUGBANK:Edaravone) decreases path(MESH:"Plaque, Amyloid") |
| pubmed:31248781 | a(DRUGBANK:Edaravone) decreases path(CONSO:neuroinflammation) |
| pubmed:31248781 | a(DRUGBANK:Edaravone) decreases deg(a(MESH:Neurites)) |
| pubmed:31248781 | a(DRUGBANK:Edaravone) decreases deg(a(MESH:Dendrites)) |
| pubmed:31248781 | a(DRUGBANK:Edaravone) increases bp(GO:"synaptic signaling") |
| pubmed:31248781 | a(DRUGBANK:Edaravone) increases bp(GO:behavior) |
| pubmed:31248781 | p(MESH:"Amyloid beta-Peptides", frag("1_?")) regulates act(p(MESH:"Amyloid beta-Peptides", loc(MESH:Neurons))) |
| pubmed:31248781 | p(MESH:"Amyloid beta-Peptides", frag("1_?")) decreases path(CONSO:"mitochondrial dysfunction") |
| pubmed:31248781 | p(MESH:"Amyloid beta-Peptides", frag("1_?")) decreases path(MESH:"Oxidative Stress") |
| pubmed:31248781 | p(MESH:"Amyloid beta-Peptides", frag("1_?")) decreases bp(GO:"neuron apoptotic process") |
| pubmed:31248781 | p(MESH:"Amyloid beta-Peptides", frag("1_?")) increases bp(MESH:Neuroprotection) |
| pubmed:31248781 | p(MESH:"Amyloid beta-Peptides", frag("1_?")) positiveCorrelation bp(GO:behavior) |
| pubmed:31248781 | p(MESH:"Amyloid beta-Peptides", frag("1_?")) decreases path(MESH:"Cell Death") |
| pubmed:31248781 | p(MESH:"Amyloid beta-Peptides", frag("1_?")) increases bp(GO:"synaptic signaling") |
| pubmed:31248781 | p(MESH:"Amyloid beta-Peptides") increases path(CONSO:"mitochondrial dysfunction") |
| pubmed:31248781 | p(MESH:"Amyloid beta-Peptides") increases path(MESH:"Oxidative Stress") |
| pubmed:31248781 | p(MESH:"Amyloid beta-Peptides") decreases bp(GO:"neuron apoptotic process") |
| pubmed:31248781 | composite(p(MESH:"Amyloid Precursor Protein Secretases"), p(MESH:"Amyloid beta-Peptides")) increases p(MESH:"Amyloid beta-Peptides", frag("1_15")) |
| pubmed:31248781 | composite(p(MESH:"Amyloid Precursor Protein Secretases"), p(MESH:"Amyloid beta-Peptides")) increases p(MESH:"Amyloid beta-Peptides", frag("1_16")) |
| pubmed:26195256 | act(p(MESH:"Amyloid Precursor Protein Secretases")) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta), p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments"))) |
| pubmed:31248781 | p(MESH:"Amyloid beta-Peptides", frag("1_15")) decreases a(CONSO:"amyloid-beta oligomers") |
| pubmed:31248781 | p(MESH:"Amyloid beta-Peptides", frag("1_15")) regulates act(p(MESH:"Amyloid beta-Peptides", loc(MESH:Neurons))) |
| pubmed:31248781 | p(MESH:"Amyloid beta-Peptides", frag("1_16")) decreases a(CONSO:"amyloid-beta oligomers") |
| pubmed:31248781 | p(MESH:"Amyloid beta-Peptides", frag("1_16")) regulates act(p(MESH:"Amyloid beta-Peptides", loc(MESH:Neurons))) |
| pubmed:16273023 | path(MESH:D000544) association path(MESH:D016874) |
| pubmed:16273023 | path(MESH:D000544) association path(MESH:D058225) |
| pubmed:16273023 | path(MESH:D000544) association bp(GO:"GO:0070997") |
| pubmed:16273023 | path(MESH:D000544) decreases bp(MESH:D009435) |
| pubmed:16273023 | path(MESH:D000544) decreases bp(GO:"GO:0007271") |
| pubmed:16273023 | path(MESH:D000544) decreases bp(GO:"GO:0035249") |
| pubmed:16273023 | path(MESH:D000544) decreases act(p(HGNC:CHAT), ma(go:0003824 ! "catalytic activity")) |
| pubmed:16273023 | path(MESH:D000544) decreases bp(GO:"GO:0015871") |
| pubmed:16273023 | path(MESH:D000544) decreases bp(GO:"GO:0008292") |
| pubmed:16273023 | path(MESH:D000544) causesNoChange p(MESH:D011950) |
| pubmed:16273023 | path(MESH:D000544) decreases bp(GO:"GO:0051935") |
| pubmed:16273023 | path(MESH:D000544) decreases bp(GO:"GO:0014047") |
| pubmed:16273023 | path(MESH:D000544) decreases bp(GO:"GO:0014047") |
| pubmed:16273023 | path(MESH:D000544) decreases bp(MESH:D017774) |
| pubmed:16273023 | path(MESH:D000544) decreases bp(MESH:D017774) |
| pubmed:16273023 | path(MESH:D000544) decreases complex(a(CHEBI:"magnesium(2+)"), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pubmed:16273023 | path(MESH:D016874) association path(MESH:D000544) |
| pubmed:16273023 | path(MESH:D058225) association path(MESH:D000544) |
| pubmed:16273023 | bp(GO:"GO:0070997") association path(MESH:D000544) |
| pubmed:16273023 | bp(GO:"GO:0070997") association act(p(MESH:D017470)) |
| pubmed:16273023 | bp(GO:"GO:0007271") association path(MESH:D003071) |
| pubmed:16273023 | bp(GO:"GO:0007271") association path(MESH:D003071) |
| pubmed:16273023 | bp(GO:"GO:0007271") association a(MESH:D002800) |
| pubmed:16273023 | bp(GO:"GO:0035249") association path(MESH:D003071) |
| pubmed:16273023 | bp(GO:"GO:0035249") association path(MESH:D003071) |
| pubmed:16273023 | bp(GO:"GO:0035249") increases bp(GO:"GO:0051935") |
| pubmed:16273023 | bp(GO:"GO:0035249") association a(CHEBI:"NMDA receptor antagonist") |
| pubmed:16273023 | path(MESH:D003071) association bp(GO:"GO:0035249") |
| pubmed:16273023 | path(MESH:D003071) association bp(GO:"GO:0035249") |
| pubmed:16273023 | path(MESH:D003071) association bp(GO:"GO:0007271") |
| pubmed:16273023 | path(MESH:D003071) association bp(GO:"GO:0007271") |
| pubmed:16273023 | bp(GO:"GO:0008292") negativeCorrelation path(MESH:D003704) |
| pubmed:16273023 | path(MESH:D003704) negativeCorrelation bp(GO:"GO:0008292") |
| pubmed:16273023 | path(MESH:D013850) association a(MESH:D006624) |
| pubmed:16273023 | path(MESH:D013850) association a(MESH:D019579) |
| pubmed:16273023 | path(MESH:D013850) association a(CHEBI:"glutamate(1-)") |
| pubmed:16273023 | a(MESH:D006624) association path(MESH:D013850) |
| pubmed:16273023 | a(MESH:D006624) association path(MESH:D008568) |
| pubmed:16273023 | a(MESH:D019579) association path(MESH:D013850) |
| pubmed:16273023 | a(MESH:D019579) association path(MESH:D008568) |
| pubmed:16273023 | path(MESH:D008568) association a(MESH:D006624) |
| pubmed:16273023 | path(MESH:D008568) association a(MESH:D019579) |
| pubmed:16273023 | path(MESH:D008568) association a(CHEBI:"glutamate(1-)") |
| pubmed:16273023 | path(MESH:D008568) association bp(MESH:D017774) |
| pubmed:16273023 | act(p(HGNC:GLS), ma(go:0003824 ! "catalytic activity")) directlyIncreases a(CHEBI:"glutamate(1-)") |
| pubmed:16273023 | bp(GO:"GO:0014047") increases bp(GO:"GO:0035249") |
| pubmed:16273023 | bp(GO:"GO:0014047") increases bp(MESH:D017774) |
| pubmed:16273023 | bp(GO:"GO:0051935") increases a(CHEBI:glutamine) |
| pubmed:16273023 | a(CHEBI:glutamine) increases bp(GO:"GO:0006868") |
| pubmed:16273023 | act(p(MESH:D017470)) association bp(GO:"GO:0070997") |
| pubmed:16273023 | bp(MESH:D017774) association path(MESH:D008568) |
| pubmed:16273023 | bp(MESH:D017774) association path(MESH:D007858) |
| pubmed:16273023 | path(MESH:D007858) association bp(MESH:D017774) |
| pubmed:16273023 | a(MESH:D017966) association composite(p(MESH:D011950), p(MESH:D017470)) |
| pubmed:16273023 | composite(p(MESH:D011950), p(MESH:D017470)) association a(MESH:D017966) |
| pubmed:16273023 | a(MESH:D002800) increases bp(GO:"GO:0014047") |
| pubmed:16273023 | a(MESH:D002800) increases bp(GO:"GO:0014047") |
| pubmed:16273023 | a(MESH:D002800) increases a(CHEBI:acetylcholine) |
| pubmed:16273023 | a(MESH:D002800) association bp(GO:"GO:0007271") |
| pubmed:16273023 | complex(a(CHEBI:acetylcholine), p(MESH:D011950)) increases a(CHEBI:acetylcholine) |
| pubmed:16273023 | a(CHEBI:"magnesium(2+)") decreases complex(a(CHEBI:"calcium(2+)"), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pubmed:24590577 | complex(a(CHEBI:acetylcholine), p(FPLX:"G_protein"), p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) increases bp(GO:"synaptic transmission, cholinergic") |
| pubmed:24590577 | complex(p(HGNC:CHRM1), p(HGNC:GNA11)) increases act(p(FPLX:PLC)) |
| pubmed:24590577 | complex(p(HGNC:CHRM1), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport") |
| pubmed:24590577 | complex(p(HGNC:CHRM3), p(HGNC:GNA11)) increases act(p(FPLX:PLC)) |
| pubmed:24590577 | complex(p(HGNC:CHRM3), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport") |
| pubmed:24590577 | complex(p(HGNC:CHRM5), p(HGNC:GNA11)) increases act(p(FPLX:PLC)) |
| pubmed:24590577 | complex(p(HGNC:CHRM5), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport") |
| pubmed:24590577 | complex(p(HGNC:CHRM2), p(HGNC:GNAO1)) decreases p(HGNCGENEFAMILY:"Adenylate cyclases") |
| pubmed:24590577 | complex(p(HGNC:CHRM2), p(HGNC:GNAO1)) decreases a(CHEBI:"3',5'-cyclic AMP") |
| pubmed:24590577 | complex(p(HGNC:CHRM4), p(HGNC:GNAO1)) decreases p(HGNCGENEFAMILY:"Adenylate cyclases") |
| pubmed:24590577 | complex(p(HGNC:CHRM4), p(HGNC:GNAO1)) decreases a(CHEBI:"3',5'-cyclic AMP") |
| pubmed:24590577 | path(MESH:Nociception) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pubmed:24590577 | a(MESH:Kidney) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pubmed:29626319 | a(MESH:Kidney) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | a(MESH:Kidney) decreases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | a(MESH:Kidney) decreases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | a(MESH:Kidney) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pubmed:29626319 | a(MESH:Kidney) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:24590577 | a(MESH:Thalamus) association p(HGNC:CHRM1) |
| pubmed:24762290 | a(MESH:Thalamus) association complex(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:24762290 | a(MESH:Thalamus) association complex(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:24590577 | p(MGI:Chrm2) decreases path(MESH:"Nociceptive Pain") |
| pubmed:24590577 | a(MESH:Hypothalamus) association p(HGNC:CHRM3) |
| pubmed:24590577 | p(MGI:Chrm3) regulates bp(GO:"response to food") |
| pubmed:24590577 | p(MGI:Chrm3) increases bp(GO:"pituitary gland development") |
| pubmed:24590577 | p(MGI:Chrm3) increases p(MGI:Prl) |
| pubmed:24590577 | p(MGI:Chrm3) increases p(MGI:Gh) |
| pubmed:24590577 | p(MGI:Chrm3) increases bp(GO:"multicellular organism growth") |
| pubmed:24590577 | a(CHEBI:benzoxazine) decreases act(p(HGNC:CHRM4)) |
| pubmed:24590577 | a(CHEBI:benzoxazine) decreases path(MESH:"Parkinson Disease") |
| pubmed:30027901 | bp(GO:"response to drug") decreases path(HP:Irritability) |
| pubmed:30027901 | bp(GO:"response to drug") decreases path(MESH:Anger) |
| pubmed:30027901 | bp(GO:"response to drug") decreases path(MESH:Depression) |
| pubmed:22020111 | a(CHEBI:cocaine) decreases act(p(HGNC:SLC7A11)) |
| pubmed:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(MGI:Bace1) |
| pubmed:18986241 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(MGI:Bace1) |
| pubmed:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases a(CHEBI:amyloid-beta) |
| pubmed:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases path(MESH:Tauopathies) |
| pubmed:18986241 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases path(MESH:Tauopathies) |
| pubmed:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") increases act(p(FPLX:PKC)) |
| pubmed:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases act(p(HGNC:GSK3B)) |
| pubmed:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases path(MESH:"Plaque, Amyloid") |
| pubmed:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") increases bp(GO:memory) |
| pubmed:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") increases bp(GO:learning) |
| pubmed:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:18986241 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases path(MESH:"Sjogren's Syndrome") |
| pubmed:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") causesNoChange p(HGNC:APP) |
| pubmed:18986241 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases path(MESH:"Cognitive Dysfunction") |
| pubmed:18986241 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") increases act(p(MGI:Chrm1)) |
| pubmed:18986241 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases act(p(MGI:Gsk3b)) |
| pubmed:24401760 | act(p(MGI:Bace1)) increases a(CHEBI:amyloid-beta) |
| pubmed:24590577 | complex(p(HGNC:BACE1), p(HGNC:CHRM1)) increases deg(p(HGNC:BACE1)) |
| pubmed:24590577 | bp(GO:"Wnt signaling pathway") decreases path(CONSO:neurotoxicity) |
| pubmed:23454242 | bp(GO:"Wnt signaling pathway") association p(FPLX:PPP2) |
| pubmed:18494933 | bp(GO:"Wnt signaling pathway") increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:18494933 | bp(GO:"Wnt signaling pathway") negativeCorrelation act(p(HGNC:GSK3B)) |
| pubmed:24590577 | a(MESH:cevimeline) increases act(p(HGNC:CHRM1)) |
| pubmed:24590577 | a(MESH:"1-((4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid") increases act(p(MGI:Chrm1)) |
| pubmed:24590577 | a(MESH:"1-((4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid") increases bp(GO:memory) |
| pubmed:24590577 | a(MESH:"1-((4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid") increases path(MESH:"Executive Function") |
| pubmed:24590577 | complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) increases p(CONSO:sAPP-alpha) |
| pubmed:24590577 | complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) decreases a(CHEBI:amyloid-beta) |
| pubmed:24590577 | complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) increases bp(GO:"signal transduction") |
| pubmed:24590577 | a(CHEBI:cevimeline) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:24590577 | a(CHEBI:cevimeline) decreases path(MESH:"Sjogren's Syndrome") |
| pubmed:24590577 | a(CHEBI:cevimeline) causesNoChange p(HGNC:APP) |
| pubmed:24590577 | a(CHEBI:cevimeline) decreases a(CHEBI:amyloid-beta) |
| pubmed:24590577 | a(CHEBI:cevimeline) causesNoChange p(CONSO:sAPP-alpha) |
| pubmed:24590577 | a(CHEBI:cevimeline) increases path(MESH:Confusion) |
| pubmed:24590577 | a(CHEBI:cevimeline) increases path(MESH:Diarrhea) |
| pubmed:24590577 | a(CHEBI:cevimeline) increases path(MESH:Asthenia) |
| pubmed:24590577 | a(CHEBI:cevimeline) increases path(MESH:"Gastrointestinal Diseases") |
| pubmed:24590577 | a(MESH:"talsaclidine fumarate") increases p(CONSO:sAPP-alpha) |
| pubmed:24590577 | a(MESH:"talsaclidine fumarate") decreases a(CHEBI:amyloid-beta) |
| pubmed:24590577 | a(MESH:"talsaclidine fumarate") increases path(MESH:Sweating) |
| pubmed:24590577 | a(MESH:"talsaclidine fumarate") increases path(MESH:Salivation) |
| pubmed:24590577 | a(MESH:"WAY 132983") increases bp(GO:cognition) |
| pubmed:24590577 | a(MESH:"WAY 132983") increases path(MESH:Salivation) |
| pubmed:24590577 | a(MESH:"WAY 132983") increases path(MESH:Hypothermia) |
| pubmed:24590577 | a(CONSO:VU0029767) increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1)) |
| pubmed:24590577 | a(CONSO:VU0090157) increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1)) |
| pubmed:24590577 | a(CONSO:VU0184670) increases act(p(HGNC:CHRM1)) |
| pubmed:24590577 | a(CONSO:VU0184670) causesNoChange act(p(HGNC:CHRM2)) |
| pubmed:24590577 | a(CONSO:VU0184670) causesNoChange act(p(HGNC:CHRM5)) |
| pubmed:24590577 | a(CONSO:VU0184670) increases bp(GO:"NMDA selective glutamate receptor signaling pathway") |
| pubmed:29428175 | path(MESH:"Substance-Related Disorders") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:29428175 | composite(a(CHEBI:"calcium ion"), p(HGNC:CHRNA7)) regulates tloc(a(CHEBI:neurotransmitter), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:29428175 | composite(a(CHEBI:"calcium ion"), p(HGNC:CHRNA7)) regulates tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:29428175 | composite(a(CHEBI:"calcium ion"), p(HGNC:CHRNA7)) regulates tloc(a(DRUGBANK:Norepinephrine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:29428175 | composite(a(CHEBI:"calcium ion"), p(HGNC:CHRNA7)) regulates tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:29428175 | composite(a(CHEBI:"calcium ion"), p(HGNC:CHRNA7)) regulates bp(GO:"glutamate secretion") |
| pubmed:29428175 | composite(a(CHEBI:"calcium ion"), p(HGNC:CHRNA7)) positiveCorrelation bp(GO:"regulation of presynaptic membrane potential") |
| pubmed:29428175 | bp(GO:"glutamate secretion") positiveCorrelation act(p(HGNC:CHRNA7)) |
| pubmed:29428175 | bp(GO:"glutamate secretion") positiveCorrelation bp(MESH:"Long-Term Potentiation") |
| pubmed:29428175 | bp(GO:"regulation of presynaptic membrane potential") positiveCorrelation composite(a(CHEBI:"calcium ion"), p(HGNC:CHRNA7)) |
| pubmed:29428175 | bp(GO:"regulation of presynaptic membrane potential") negativeCorrelation p(CONSO:alpha-Bungarotoxin) |
| pubmed:29428175 | bp(MESH:"Calcium Signaling") increases bp(GO:"glutamate secretion") |
| pubmed:29428175 | bp(MESH:"Calcium Signaling") increases tloc(a(MESH:"Synaptic Vesicles"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:29428175 | bp(MESH:"Calcium Signaling") increases act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) |
| pubmed:29428175 | bp(MESH:"Calcium Signaling") increases act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) |
| pubmed:29428175 | bp(MESH:"Calcium Signaling") regulates bp(GO:"neuronal signal transduction") |
| pubmed:29428175 | bp(MESH:"Calcium Signaling") regulates act(complex(GO:"protein kinase complex")) |
| pubmed:29428175 | bp(MESH:"Calcium Signaling") regulates bp(GO:"gene expression") |
| pubmed:29428175 | bp(MESH:"Calcium Signaling") positiveCorrelation p(HGNC:CAMK2B) |
| pubmed:29428175 | bp(MESH:"Calcium Signaling") association p(HGNC:CAMK2B) |
| pubmed:29428175 | bp(MESH:"Calcium Signaling") association bp(GO:"positive regulation of cAMP-dependent protein kinase activity") |
| pubmed:29428175 | bp(MESH:"Calcium Signaling") increases p(HGNC:CREBZF) |
| pubmed:29428175 | tloc(a(MESH:"Synaptic Vesicles"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases bp(MESH:"Neuronal Plasticity") |
| pubmed:30027901 | a(MESH:"Synaptic Vesicles") association p(HGNC:HTT) |
| pubmed:29428175 | bp(GO:"calcium ion import across plasma membrane") increases bp(MESH:"Calcium Signaling") |
| pubmed:29428175 | bp(GO:"calcium ion import across plasma membrane") increases bp(MESH:"Calcium Signaling") |
| pubmed:29428175 | p(HGNC:CHRNA7, var("p.Asp44Ala")) decreases bp(GO:"calcium ion import across plasma membrane") |
| pubmed:29428175 | p(HGNC:CHRNA7, var("p.Asp44Ala")) decreases complex(a(CHEBI:choline), p(HGNC:CHRNA7)) |
| pubmed:29428175 | p(HGNC:CHRNA7, var("p.Asp44Ala")) decreases act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) |
| pubmed:29428175 | p(HGNC:CHRNA7, var("p.Asp44Ala")) decreases bp(GO:"neuron projection development") |
| pubmed:29428175 | complex(a(CHEBI:choline), p(HGNC:CHRNA7)) increases act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) |
| pubmed:29428175 | complex(a(CHEBI:choline), p(HGNC:CHRNA7)) increases act(p(HGNC:CHRNA7)) |
| pubmed:29428175 | complex(a(CHEBI:choline), p(HGNC:CHRNA7)) increases bp(GO:"activation of phospholipase C activity") |
| pubmed:29428175 | a(DRUGBANK:Dantrolene) decreases p(HGNCGENEFAMILY:"Ryanodine receptors") |
| pubmed:29428175 | a(DRUGBANK:Dantrolene) decreases act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) |
| pubmed:21482353 | bp(GO:"neuron maturation") positiveCorrelation p(HGNC:LYNX1) |
| pubmed:29428175 | a(CHEBI:calcineurin) regulates a(GO:cytoskeleton) |
| pubmed:29428175 | p(MESH:"Inositol 1,4,5-Trisphosphate Receptors") increases a(CHEBI:"calcium ion", loc(MESH:"Intracellular Space")) |
| pubmed:29428175 | p(MESH:"Inositol 1,4,5-Trisphosphate Receptors") increases bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") |
| pubmed:29428175 | a(CHEBI:"xestospongin C") decreases act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) |
| pubmed:29428175 | a(MESH:Phospholipids) association bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") |
| pubmed:29428175 | bp(GO:"positive regulation of cAMP-dependent protein kinase activity") association bp(MESH:"Calcium Signaling") |
| pubmed:29428175 | bp(GO:"positive regulation of cAMP-dependent protein kinase activity") regulates p(MESH:"Ion Channels") |
| pubmed:29428175 | bp(GO:"positive regulation of cAMP-dependent protein kinase activity") regulates p(MESH:"Cytoskeletal Proteins") |
| pubmed:29428175 | bp(GO:"positive regulation of cAMP-dependent protein kinase activity") regulates p(HGNC:CHRNA7) |
| pubmed:29428175 | bp(GO:"positive regulation of cAMP-dependent protein kinase activity") increases tloc(a(CHEBI:"L-glutamate(1-)", loc(MESH:"Presynaptic Terminals")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:19491104 | bp(GO:"vesicle-mediated transport") positiveCorrelation act(complex(GO:"kinesin complex")) |
| pubmed:29428175 | act(p(HGNC:ADCY1)) increases bp(GO:"positive regulation of cAMP-dependent protein kinase activity") |
| pubmed:26979166 | act(p(HGNC:ADCY1)) directlyIncreases a(MESH:"Cyclic AMP") |
| pubmed:26979166 | act(p(HGNC:ADCY1)) directlyIncreases a(MESH:"Cyclic AMP") |
| pubmed:29428175 | p(HGNC:CREBZF) increases bp(GO:"learning or memory") |
| pubmed:27299292 | p(HGNC:CREBZF) increases p(HGNC:TFEB) |
| pubmed:27299292 | p(HGNC:CREBZF) regulates act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:29428175 | a(CHEBI:"cholinergic agonist") regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:29428175 | a(CHEBI:"cholinergic agonist") association bp(MESH:"Immunity, Cellular") |
| pubmed:29428175 | a(CHEBI:"cholinergic agonist") association path(MESH:"Immune System Diseases") |
| pubmed:29428175 | a(CHEBI:"cholinergic agonist") association path(MESH:Inflammation) |
| pubmed:29428175 | bp(MESH:"Immunity, Cellular") association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:29428175 | bp(MESH:"Immunity, Cellular") association a(CHEBI:"cholinergic agonist") |
| pubmed:26979166 | bp(MESH:"Immunity, Cellular") increases p(HGNC:CHRNA7) |
| pubmed:30988501 | bp(MESH:"Immunity, Cellular") association bp(GO:cognition) |
| pubmed:30988501 | bp(MESH:"Immunity, Cellular") association bp(GO:cognition) |
| pubmed:30988501 | bp(MESH:"Immunity, Cellular") association path(MESH:"Mood Disorders") |
| pubmed:30988501 | bp(MESH:"Immunity, Cellular") association path(MESH:"Social Behavior") |
| pubmed:30988501 | bp(MESH:"Immunity, Cellular") association path(MESH:"Illness Behavior") |
| pubmed:30988501 | bp(MESH:"Immunity, Cellular") increases path(HP:Autoimmunity) |
| pubmed:29428175 | path(MESH:"Immune System Diseases") association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:29428175 | path(MESH:"Immune System Diseases") association a(CHEBI:"cholinergic agonist") |
| pubmed:23702978 | path(MESH:"Immune System Diseases") increases path(MESH:Atherosclerosis) |
| pubmed:23702978 | path(MESH:"Immune System Diseases") increases path(MESH:"Diabetes Mellitus, Type 2") |
| pubmed:23702978 | path(MESH:"Immune System Diseases") increases path(MESH:"Neurodegenerative Diseases") |
| pubmed:29428175 | a(CHEBI:"cholinergic antagonist") decreases p(HGNC:CHRNA7) |
| pubmed:29428175 | a(CHEBI:"cholinergic antagonist") decreases p(HGNC:TNF) |
| pubmed:27314526 | bp(GO:"cytokine secretion") increases bp(GO:"inflammatory response") |
| pubmed:30988501 | bp(GO:"cytokine secretion") association act(a(MESH:"Central Nervous System")) |
| pubmed:29428175 | complex(a(CHEBI:nicotine), p(HGNC:CHRNA4)) increases complex(p(HGNC:CHRNA4), p(HGNCGENEFAMILY:"G protein subunits alpha, group i")) |
| pubmed:29428175 | complex(p(HGNC:CHRNA4), p(HGNCGENEFAMILY:"G protein subunits alpha, group i")) increases bp(GO:"cytokine secretion") |
| pubmed:29428175 | complex(p(HGNC:CHRNA4), p(HGNCGENEFAMILY:"G protein subunits alpha, group i")) increases bp(GO:"T cell proliferation") |
| pubmed:29428175 | complex(p(HGNC:CHRNA4), p(HGNCGENEFAMILY:"G protein subunits alpha, group i")) association p(HGNC:CDC42) |
| pubmed:29428175 | p(HGNC:CDC42) association complex(p(HGNC:CHRNA4), p(HGNCGENEFAMILY:"G protein subunits alpha, group i")) |
| pubmed:29428175 | act(p(HGNC:CDC42), ma(GO:"GTPase activity")) regulates bp(MESH:"Cell Movement") |
| pubmed:29428175 | bp(GO:"ion channel modulating, G protein-coupled receptor signaling pathway") regulates bp(GO:"calcium ion homeostasis") |
| pubmed:29428175 | bp(GO:"ion channel modulating, G protein-coupled receptor signaling pathway") regulates bp(GO:"store-operated calcium entry") |
| pubmed:29428175 | bp(GO:"ion channel modulating, G protein-coupled receptor signaling pathway") regulates bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") |
| pubmed:29428175 | bp(GO:"store-operated calcium entry") regulates bp(GO:"calcium ion homeostasis") |
| pubmed:29428175 | complex(p(HGNC:CHRNA7), p(HGNCGENEFAMILY:"G protein subunits alpha, group i")) increases tloc(a(CHEBI:"calcium(2+)", loc(MESH:"Endoplasmic Reticulum")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:29428175 | a(PUBCHEM:9795278) increases act(p(HGNC:CHRNA7)) |
| pubmed:29428175 | complex(p(HGNC:CHRNA7), p(HGNCGENEFAMILY:"G protein subunits alpha, group q")) increases bp(GO:"activation of phospholipase C activity") |
| pubmed:29428175 | complex(p(HGNC:CHRNA7), p(HGNCGENEFAMILY:"G protein subunits alpha, group q")) increases bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") |
| pubmed:29428175 | bp(GO:"activation of phospholipase C activity") increases bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") |
| pubmed:29428175 | complex(complex(GO:"SNARE complex"), p(HGNCGENEFAMILY:"G protein subunits beta"), p(HGNCGENEFAMILY:"G protein subunits gamma")) regulates bp(GO:"neurotransmitter secretion") |
| pubmed:29758300 | tloc(complex(GO:"SNARE complex"), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) increases deg(a(CONSO:"Tau aggregates")) |
| pubmed:26088141 | p(HGNCGENEFAMILY:"G protein subunits beta") increases complex(p(FPLX:"G_protein"), p(HGNC:CHRNA7)) |
| pubmed:29428175 | complex(p(HGNC:CHRNA7), p(PUBCHEM:9795278)) increases bp(GO:"activation of phospholipase C activity") |
| pubmed:29428175 | complex(p(HGNC:CHRNA7), p(PUBCHEM:9795278)) increases act(p(HGNC:CHRNA7)) |
| pubmed:29428175 | complex(a(CHEBI:nicotine), p(HGNC:CHRNA7), p(HGNCGENEFAMILY:"G protein subunits alpha, group q")) increases bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") |
| pubmed:29428175 | complex(a(CHEBI:choline), p(HGNC:CHRNA7), p(HGNCGENEFAMILY:"G protein subunits alpha, group q")) increases bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") |
| pubmed:29428175 | complex(p(HGNC:CHRNA7), p(HGNCGENEFAMILY:"G protein subunits alpha, group q"), p(PUBCHEM:9795278)) increases bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") |
| pubmed:29428175 | p(GO:spectrin) increases bp(GO:"cytoskeleton organization") |
| pubmed:29428175 | composite(p(HGNC:CHRNA7), p(HGNC:GPRIN1)) increases p(HGNC:CHRNA7, loc(MESH:"Growth Cones")) |
| pubmed:29428175 | complex(complex(GO:"heterotrimeric G-protein complex"), p(HGNC:CHRNA7)) increases act(p(HGNC:RHOA), ma(GO:"GTPase activity")) |
| pubmed:29428175 | complex(complex(GO:"heterotrimeric G-protein complex"), p(HGNC:CHRNA7)) association path(MESH:"Behavior, Addictive") |
| pubmed:29428175 | act(p(HGNC:RHOA), ma(GO:"GTPase activity")) increases a(GO:"actin cytoskeleton", loc(MESH:Synapses)) |
| pubmed:29428175 | act(p(HGNC:RHOA), ma(GO:"GTPase activity")) increases a(MESH:Cytoskeleton, loc(MESH:Synapses)) |
| pubmed:27796283 | act(p(HGNC:RHOA)) regulates bp(GO:"dendritic spine development") |
| pubmed:27796283 | act(p(HGNC:RHOA)) association act(p(HGNC:ARHGEF2)) |
| pubmed:27796283 | act(p(HGNC:RHOA)) negativeCorrelation a(MESH:"Dendritic Spines") |
| pubmed:27796283 | act(p(HGNC:RHOA)) regulates a(MESH:"Dendritic Spines") |
| pubmed:27796283 | act(p(HGNC:RHOA)) negativeCorrelation act(a(GO:synapse)) |
| pubmed:27796283 | act(p(HGNC:RHOA)) positiveCorrelation complex(p(HGNC:ARHGEF2), p(HGNC:RHOA)) |
| pubmed:28901280 | bp(MESH:"Cell Movement") association a(MESH:Acetylcholine) |
| pubmed:29428175 | g(HGNC:RHOA, var("?")) positiveCorrelation path(MESH:Smoking) |
| pubmed:29428175 | g(HGNC:RHOA, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") |
| pubmed:26979166 | bp(GO:"membrane hyperpolarization") increases a(CHEBI:"calcium ion", loc(GO:nucleus)) |
| pubmed:26979166 | a(MESH:"Cyclic AMP") directlyIncreases act(p(HGNC:PRKACA)) |
| pubmed:26979166 | a(MESH:"Cyclic AMP") directlyIncreases act(p(HGNC:PRKACA)) |
| pubmed:26979166 | bp(GO:"protein kinase A signaling") directlyIncreases p(HGNC:CREB1) |
| pubmed:26979166 | bp(GO:"protein kinase A signaling") directlyDecreases p(HGNC:GSK3B) |
| pubmed:26979166 | act(p(HGNC:TLR9)) increases r(MESH:Cytokines) |
| pubmed:26979166 | p(MESH:Cytokines) increases path(MESH:Inflammation) |
| pubmed:26979166 | p(FPLX:"PI3K_p85", pmod(go:0006468 ! "protein phosphorylation", Tyr)) directlyIncreases act(p(HGNC:AKT1)) |
| pubmed:26979166 | act(p(MESH:"NF-kappa B")) increases path(MESH:Inflammation) |
| pubmed:26979166 | act(p(HGNC:GABPA)) decreases path(MESH:"Oxidative Stress") |
| pubmed:26979166 | act(p(HGNC:GABPA)) decreases path(MESH:Inflammation) |
| pubmed:26979166 | act(p(MESH:"Receptors, Glucocorticoid")) increases p(HGNC:CHRNA7) |
| pubmed:26979166 | a(PUBCHEM:311434) decreases p(HGNC:TNF) |
| pubmed:26979166 | a(PUBCHEM:311434) decreases p(HGNC:IL6) |
| pubmed:26979166 | a(PUBCHEM:311434) decreases path(MESH:Inflammation) |
| pubmed:26979166 | composite(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:RIC3)) increases complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7)) |
| pubmed:26979166 | composite(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:SLURP1)) increases complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7)) |
| pubmed:26979166 | p(HGNC:SLURP1) increases act(complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7))) |
| pubmed:26979166 | composite(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:LYNX1)) increases complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7)) |
| pubmed:26979166 | p(HGNC:LYNX1) increases act(complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7))) |
| pubmed:21482353 | p(HGNC:LYNX1) regulates act(p(FPLX:CHRN)) |
| pubmed:21482353 | p(HGNC:LYNX1) decreases act(p(FPLX:CHRN)) |
| pubmed:21482353 | p(HGNC:LYNX1) decreases act(p(FPLX:CHRN)) |
| pubmed:21482353 | p(HGNC:LYNX1) regulates act(p(FPLX:CHRN)) |
| pubmed:21482353 | p(HGNC:LYNX1) decreases bp(GO:"synaptic transmission, cholinergic") |
| pubmed:21482353 | p(HGNC:LYNX1) association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:21482353 | p(HGNC:LYNX1) association path(MESH:"Cognitive Dysfunction") |
| pubmed:21482353 | p(HGNC:LYNX1) positiveCorrelation bp(GO:"neuron maturation") |
| pubmed:21482353 | p(HGNC:LYNX1) negativeCorrelation bp(GO:"synapse maturation") |
| pubmed:21482353 | p(HGNC:LYNX1) regulates bp(GO:"generation of neurons") |
| pubmed:28901280 | p(HGNC:LYNX1) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) |
| pubmed:28901280 | p(HGNC:LYNX1) decreases act(p(HGNC:CHRNA7)) |
| pubmed:26979166 | composite(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:EPHB2)) increases complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7)) |
| pubmed:26979166 | p(HGNC:EPHB2) increases act(complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7))) |
| pubmed:26979166 | composite(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:PICK1)) increases complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7)) |
| pubmed:26979166 | p(HGNC:PICK1) increases act(complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7))) |
| pubmed:26979166 | p(MESH:"Protein-Tyrosine Kinases") increases p(HGNC:CHRNA7, pmod(go:0006468 ! "protein phosphorylation", Tyr)) |
| pubmed:26979166 | p(MESH:"Protein-Tyrosine Kinases") decreases p(HGNC:CHRNA7, loc(MESH:"Cell Membrane")) |
| pubmed:26979166 | p(HGNC:CHRNA7, pmod(go:0006468 ! "protein phosphorylation", Tyr)) decreases act(p(HGNC:CHRNA7)) |
| pubmed:22040696 | p(HGNC:CHRNA7, pmod(go:0006468 ! "protein phosphorylation", Tyr)) decreases act(p(HGNC:CHRNA7)) |
| pubmed:26979166 | a(CHEBI:Genisteine) decreases p(MESH:"Protein-Tyrosine Kinases") |
| pubmed:26979166 | a(CHEBI:Genisteine) increases act(p(HGNC:CHRNA7)) |
| pubmed:26979166 | a(CHEBI:Genisteine) increases p(HGNC:CHRNA7, loc(MESH:"Cell Membrane")) |
| pubmed:26979166 | p(HGNC:CHRNA7, pmod(go:0006468 ! "protein phosphorylation", Ser)) regulates act(p(HGNC:CHRNA7)) |
| pubmed:26979166 | act(p(HGNC:DRD5)) decreases act(p(HGNC:CHRNA7)) |
| pubmed:26979166 | act(p(HGNC:DRD5)) increases act(p(HGNC:PRKACA)) |
| pubmed:26979166 | p(HGNC:CHRNA7, pmod(go:0006468 ! "protein phosphorylation", Ser, 365)) decreases act(p(HGNC:CHRNA7)) |
| pubmed:26979166 | path(MESH:"Stress, Physiological") increases path(DOID:"mental depression") |
| pubmed:26979166 | path(MESH:"Stress, Physiological") increases a(MESH:"Immune System") |
| pubmed:30108137 | path(MESH:"Stress, Physiological") association act(p(HGNC:TFEB)) |
| pubmed:30837838 | path(MESH:"Stress, Physiological") increases p(CONSO:"TDP-43 aggregates", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30837838 | path(MESH:"Stress, Physiological") increases p(CONSO:"TDP-43 aggregates", pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:26979166 | act(a(PUBCHEM:135402045)) increases a(CHEBI:dopamine) |
| pubmed:26979166 | act(a(PUBCHEM:135402045)) increases a(CHEBI:noradrenaline) |
| pubmed:26979166 | act(a(PUBCHEM:135402045)) increases a(CHEBI:serotonin) |
| pubmed:26979166 | act(a(PUBCHEM:135402045)) increases bp(GO:"microglial cell activation") |
| pubmed:26979166 | a(CHEBI:monoamine) decreases path(HP:Anhedonia) |
| pubmed:26979166 | a(CHEBI:monoamine) positiveCorrelation path(MESH:Affect) |
| pubmed:26979166 | composite(a(CHEBI:"calcium(2+)"), p(HGNC:ADCY1)) increases act(p(HGNC:ADCY1)) |
| pubmed:26979166 | complex(p(HGNC:CREB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 133)), p(HGNC:GSK3B)) increases deg(p(HGNC:CREB1)) |
| pubmed:26979166 | complex(p(HGNC:CREB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 133)), p(HGNC:GSK3B)) decreases act(p(HGNC:CREB1)) |
| pubmed:26979166 | complex(p(HGNC:CREBBP), p(MESH:"NF-kappa B")) decreases complex(p(HGNC:CREB1), p(HGNC:CREBBP)) |
| pubmed:26979166 | complex(p(HGNC:CREBBP), p(MESH:"NF-kappa B")) decreases act(p(MESH:"NF-kappa B")) |
| pubmed:26979166 | complex(p(HGNC:CREB1), p(HGNC:CREBBP)) decreases complex(p(HGNC:CREBBP), p(MESH:"NF-kappa B")) |
| pubmed:26979166 | a(PUBCHEM:11173546) decreases act(p(HGNC:CHRNA7)) |
| pubmed:26979166 | a(PUBCHEM:11173546) increases act(p(HGNC:PRKACA)) |
| pubmed:26979166 | a(PUBCHEM:11173546) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:26979166 | a(PUBCHEM:11173546) increases p(HGNC:CREB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 133)) |
| pubmed:26979166 | path(HP:Psychosis) association bp(GO:"microglial cell activation") |
| pubmed:26979166 | path(HP:Psychosis) increases a(MESH:Cytokines) |
| pubmed:26979166 | path(HP:Psychosis) increases deg(a(MESH:"White Matter")) |
| pubmed:26979166 | deg(a(MESH:"White Matter")) positiveCorrelation path(DOID:schizophrenia) |
| pubmed:25514383 | a(MESH:"White Matter") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26195256 | a(MESH:"White Matter") association path(MESH:"Alzheimer Disease") |
| pubmed:24762290 | a(MESH:"White Matter") positiveCorrelation complex(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:30012004 | a(MESH:"White Matter") negativeCorrelation path(MESH:"Huntington Disease") |
| pubmed:26979166 | a(CHEBI:prostaglandin) increases deg(a(MESH:"White Matter")) |
| pubmed:26979166 | a(CHEBI:prostaglandin) increases deg(a(MESH:"Gray Matter")) |
| pubmed:26979166 | p(HGNC:CHRFAM7A, var("?")) positiveCorrelation path(DOID:schizophrenia) |
| pubmed:26979166 | p(HGNC:CHRFAM7A, var("?")) association path(DOID:"bipolar disorder") |
| pubmed:26979166 | a(DRUGBANK:Encenicline) increases act(p(HGNC:CHRNA7)) |
| pubmed:26979166 | a(DRUGBANK:Encenicline) increases bp(GO:cognition) |
| pubmed:26979166 | a(DRUGBANK:Encenicline) decreases path(DOID:schizophrenia) |
| pubmed:26979166 | a(CHEBI:tropisetron) increases act(p(HGNC:CHRNA7)) |
| pubmed:19721446 | a(CHEBI:tropisetron) increases act(p(HGNC:CHRNA7)) |
| pubmed:26979166 | a(CHEBI:tropisetron) decreases path(DOID:schizophrenia) |
| pubmed:19721446 | a(CHEBI:tropisetron) decreases bp(MESH:"Sensory Gating") |
| pubmed:26979166 | a(PUBCHEM:10380472) increases act(p(HGNC:CHRNA7)) |
| pubmed:26979166 | a(PUBCHEM:10380472) decreases path(MESH:Depression) |
| pubmed:26979166 | a(PUBCHEM:10380472) decreases path(DOID:schizophrenia) |
| pubmed:26979166 | a(DRUGBANK:Galantamine) increases act(p(HGNC:CHRNA7)) |
| pubmed:26979166 | a(DRUGBANK:Galantamine) causesNoChange path(DOID:schizophrenia) |
| pubmed:26979166 | composite(a(DRUGBANK:Galantamine), a(PUBCHEM:305)) increases act(p(HGNC:CHRNA7)) |
| pubmed:26979166 | composite(a(DRUGBANK:Galantamine), a(PUBCHEM:305)) causesNoChange path(DOID:schizophrenia) |
| pubmed:26979166 | a(PUBCHEM:16755766) increases act(p(HGNC:CHRNA7)) |
| pubmed:26979166 | a(PUBCHEM:16755766) causesNoChange path(DOID:schizophrenia) |
| pubmed:26979166 | a(CHEBI:minocycline) decreases bp(GO:"microglial cell activation") |
| pubmed:26979166 | a(CHEBI:minocycline) decreases path(DOID:schizophrenia) |
| pubmed:29626319 | a(CHEBI:minocycline) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:30988501 | a(CHEBI:minocycline) decreases a(MESH:Microglia) |
| pubmed:30988501 | a(CHEBI:minocycline) decreases path(DOID:"mental depression") |
| pubmed:30988501 | a(CHEBI:minocycline) causesNoChange path(DOID:"autism spectrum disorder") |
| pubmed:26979166 | path(NCIT:C78349) increases path(MESH:"Irritable Mood") |
| pubmed:26979166 | path(NCIT:C78349) increases path(MESH:"Sleep Initiation and Maintenance Disorders") |
| pubmed:26979166 | path(DOID:obesity) positiveCorrelation path(MESH:Depression) |
| pubmed:26979166 | path(DOID:obesity) positiveCorrelation path(DOID:"bipolar disorder") |
| pubmed:30988501 | path(DOID:obesity) association path(MESH:Inflammation) |
| pubmed:30988501 | path(DOID:obesity) decreases act(a(MESH:Neurons)) |
| pubmed:26979166 | path(DOID:"cardiovascular system disease") positiveCorrelation path(MESH:Depression) |
| pubmed:26979166 | path(DOID:"cardiovascular system disease") positiveCorrelation path(DOID:"bipolar disorder") |
| pubmed:26979166 | complex(a(CHEBI:dopamine), p(INTERPRO:"Dopamine D2 receptor")) increases complex(p(HGNC:AKT1), p(HGNC:ARRB1), p(HGNC:GSK3B), p(HGNC:PPP2R5B), p(INTERPRO:"Dopamine D2 receptor")) |
| pubmed:26979166 | complex(p(HGNC:AKT1), p(HGNC:ARRB1), p(HGNC:GSK3B), p(HGNC:PPP2R5B), p(INTERPRO:"Dopamine D2 receptor")) increases act(p(HGNC:GSK3B)) |
| pubmed:23454242 | p(HGNC:PPP2R5B) association a(MESH:Cytosol) |
| pubmed:21882945 | p(HGNC:PPP2R5B) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21882945 | p(HGNC:PPP2R5B) increases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:26979166 | path(HP:Autism) increases path(HP:Allergy) |
| pubmed:26979166 | path(HP:Autism) increases path(MESH:Inflammation) |
| pubmed:26979166 | path(HP:Autism) increases bp(GO:"mast cell activation") |
| pubmed:26979166 | g(HGNC:MECP2, var("?")) increases path(DOID:"Rett syndrome") |
| pubmed:26979166 | g(HGNC:MECP2, var("?")) decreases p(HGNC:CHRNA7) |
| pubmed:26979166 | path(DOID:"parasitic helminthiasis infectious disease") increases a(MESH:"Th2 Cells") |
| pubmed:26979166 | p(MESH:Cholinesterases) positiveCorrelation path(DOID:dementia) |
| pubmed:26979166 | bp(GO:"glial cell-derived neurotrophic factor receptor signaling pathway") increases bp(MESH:Apoptosis) |
| pubmed:26979166 | complex(a(CHEBI:amyloid-beta), p(CONSO:"alpha-7 beta-2 nAChR")) decreases complex(a(PUBCHEM:305), p(CONSO:"alpha-7 beta-2 nAChR")) |
| pubmed:25514383 | p(CONSO:"alpha-7 beta-2 nAChR") negativeCorrelation act(a(CHEBI:amyloid-beta)) |
| pubmed:26979166 | bp(GO:"microglial cell mediated cytotoxicity") negativeCorrelation bp(GO:aging) |
| pubmed:26979166 | p(CONSO:"amyloid-beta oligomers", loc(GO:"extracellular space")) decreases complex(CONSO:"alpha-7 beta-2 nAChR", loc(MESH:"Cholinergic Neurons")) |
| pubmed:26979166 | p(CONSO:"amyloid-beta oligomers", loc(GO:"extracellular space")) increases deg(complex(CONSO:"alpha-7 beta-2 nAChR", loc(MESH:"Cholinergic Neurons"))) |
| pubmed:26088141 | p(HGNC:GNAS) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAS)) |
| pubmed:26088141 | p(HGNC:GNAI2) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAI2)) |
| pubmed:26088141 | composite(p(CONSO:alpha-Bungarotoxin), p(HGNC:CHRNA7), p(MESH:"Heterotrimeric GTP-Binding Proteins")) increases complex(p(CONSO:alpha-Bungarotoxin), p(MESH:"Heterotrimeric GTP-Binding Proteins")) |
| pubmed:26088141 | p(CONSO:"GPBC, alpha-7 nAChR") orthologous p(CONSO:"GPBC, Glycine Receptor 1") |
| pubmed:26088141 | p(CONSO:"GPBC, Glycine Receptor 1") orthologous p(CONSO:"GPBC, alpha-7 nAChR") |
| pubmed:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) causesNoChange bp(CONSO:"nAChR assembly") |
| pubmed:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) increases p(HGNC:CHRNA7) |
| pubmed:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) |
| pubmed:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) |
| pubmed:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) |
| pubmed:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) |
| pubmed:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) |
| pubmed:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) |
| pubmed:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) |
| pubmed:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases act(a(CHEBI:choline)) |
| pubmed:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases a(CHEBI:"calcium(2+)") |
| pubmed:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases act(a(CHEBI:"calcium(2+)", loc(GO:intracellular))) |
| pubmed:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases bp(GO:"calcium-mediated signaling") |
| pubmed:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases bp(MESH:"Pleckstrin Homology Domains") |
| pubmed:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) association bp(MESH:"Pleckstrin Homology Domains") |
| pubmed:26088141 | g(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) causesNoChange p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) |
| pubmed:26088141 | composite(a(CHEBI:choline), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") |
| pubmed:26088141 | composite(a(CHEBI:choline), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") |
| pubmed:26088141 | composite(a(CHEBI:choline), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) decreases a(CHEBI:"calcium(2+)") |
| pubmed:26088141 | composite(a(CHEBI:choline), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) decreases a(CHEBI:"calcium(2+)") |
| pubmed:26088141 | a(MESH:"GP Antagonist-2A peptide") causesNoChange a(CHEBI:"calcium(2+)") |
| pubmed:26088141 | a(MESH:"GP Antagonist-2A peptide") causesNoChange act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) |
| pubmed:26088141 | a(MESH:"GP Antagonist-2A peptide") decreases bp(MESH:"Pleckstrin Homology Domains") |
| pubmed:26088141 | a(MESH:Barium) causesNoChange bp(GO:"calcium-mediated signaling") |
| pubmed:26088141 | a(MESH:Barium) causesNoChange act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) |
| pubmed:26088141 | a(MESH:Barium) causesNoChange act(p(HGNC:CHRNA7)) |
| pubmed:26088141 | a(CHEBI:nifedipine) decreases act(a(CHEBI:choline)) |
| pubmed:26088141 | a(CHEBI:nifedipine) decreases a(CHEBI:"calcium(2+)") |
| pubmed:26088141 | a(CHEBI:nifedipine) increases bp(GO:"calcium-mediated signaling") |
| pubmed:26088141 | a(CHEBI:nifedipine) causesNoChange bp(GO:"calcium-mediated signaling") |
| pubmed:26088141 | a(CHEBI:nifedipine) causesNoChange act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) |
| pubmed:26088141 | bp(MESH:"Pleckstrin Homology Domains") association a(CHEBI:choline) |
| pubmed:26088141 | bp(MESH:"Pleckstrin Homology Domains") association p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) |
| pubmed:26088141 | a(MESH:"xestospongin C") decreases act(p(HGNC:CHRNA7)) |
| pubmed:26088141 | a(MESH:"xestospongin C") decreases bp(GO:"calcium-mediated signaling") |
| pubmed:26088141 | a(MESH:"xestospongin C") decreases act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) |
| pubmed:25514383 | a(HP:"cholinergic neuron") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25514383 | a(HP:"cholinergic neuron") association bp(GO:cognition) |
| pubmed:25514383 | a(HP:"cholinergic neuron") increases bp(GO:cognition) |
| pubmed:25514383 | a(HP:"cholinergic neuron") association path(MESH:Attention) |
| pubmed:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"calcium ion transport") |
| pubmed:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") positiveCorrelation bp(GO:"calcium ion transport") |
| pubmed:28445721 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"calcium ion transport") |
| pubmed:21482353 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) association bp(GO:"calcium ion transport") |
| pubmed:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates tloc(a(CHEBI:neurotransmitter), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pubmed:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"second-messenger-mediated signaling") |
| pubmed:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"neuron cellular homeostasis") |
| pubmed:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"gene expression") |
| pubmed:25514383 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases a(GO:"glutamatergic synapse") |
| pubmed:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:25514383 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) regulates tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:25514383 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases bp(GO:"positive regulation of synaptic plasticity") |
| pubmed:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"positive regulation of synaptic plasticity") |
| pubmed:25514383 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases bp(GO:"intracellular signal transduction") |
| pubmed:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"ERK1 and ERK2 cascade") |
| pubmed:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") decreases bp(HP:Neurodegeneration) |
| pubmed:25514383 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases bp(HP:Neurodegeneration) |
| pubmed:25514383 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases bp(MESH:"Cell Survival") |
| pubmed:25514383 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases a(GO:synapse) |
| pubmed:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases act(a(CHEBI:"pregnenolone sulfate")) |
| pubmed:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:cognition) |
| pubmed:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"synaptic transmission, glutamatergic") |
| pubmed:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases act(a(CHEBI:simvastatin)) |
| pubmed:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:memory) |
| pubmed:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") decreases bp(GO:"apoptotic process") |
| pubmed:28445721 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association bp(MESH:"Physiological Phenomena") |
| pubmed:28445721 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association path(MESH:Disease) |
| pubmed:21482353 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases act(p(MGI:Lynx1)) |
| pubmed:21482353 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) association bp(GO:"generation of neurons") |
| pubmed:21482353 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"sensory processing") |
| pubmed:21482353 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"sensory processing") |
| pubmed:21482353 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association a(HP:"inhibitory interneuron") |
| pubmed:21482353 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases a(HP:"inhibitory interneuron") |
| pubmed:21482353 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association path(MESH:Schizophrenia) |
| pubmed:28132910 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) negativeCorrelation a(CONSO:B-973) |
| pubmed:30664622 | a(GO:"glutamatergic synapse") association act(a(PUBCHEM:9832404)) |
| pubmed:30664622 | a(GO:"glutamatergic synapse") association act(p(HGNC:ADNP)) |
| pubmed:27013968 | act(a(GO:"glutamatergic synapse", loc(MESH:Thalamus))) increases bp(GO:"locomotory behavior") |
| pubmed:25514383 | complex(a(CHEBI:amyloid-beta), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) decreases bp(HP:Neurodegeneration) |
| pubmed:25514383 | complex(a(CHEBI:amyloid-beta), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) decreases a(CONSO:"amyloid-beta aggregates") |
| pubmed:25514383 | p(HGNC:APP, frag("12_28")) increases complex(p(HGNC:APP, frag("12_28")), p(HGNC:CHRNA7)) |
| pubmed:25514383 | complex(a(CHEBI:amyloid-beta), p(FPLX:CHRN)) increases bp(GO:"intracellular signal transduction") |
| pubmed:25514383 | complex(a(CHEBI:amyloid-beta), p(FPLX:CHRN)) decreases bp(MESH:"Cell Survival") |
| pubmed:25514383 | complex(a(CHEBI:amyloid-beta), p(FPLX:CHRN)) association bp(GO:"neuron cellular homeostasis") |
| pubmed:27522251 | complex(a(CHEBI:amyloid-beta), p(FPLX:CHRN)) increases path(MESH:"Memory Disorders") |
| pubmed:25514383 | a(PUBCHEM:637026) increases act(p(CONSO:"beta-2-containing nAChR")) |
| pubmed:25514383 | a(CONSO:"amyloid-beta 40 oligomers") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:25514383 | composite(a(CHEBI:amyloid-beta), a(CHEBI:nicotine)) increases act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:28420982 | bp(GO:"intracellular signal transduction") association p(HGNC:MAPT) |
| pubmed:25514383 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Val717Phe")) decreases path(MESH:"Spatial Memory") |
| pubmed:18986241 | path(MESH:"Cognition Disorders") negativeCorrelation p(HGNC:NTRK1) |
| pubmed:18986241 | path(MESH:"Cognition Disorders") positiveCorrelation a(MESH:"pro-nerve growth factor, human") |
| pubmed:18986241 | path(MESH:"Cognition Disorders") positiveCorrelation act(p(HGNC:MMP9)) |
| pubmed:28901280 | path(MESH:"Cognition Disorders") association p(MESH:"Receptors, Nicotinic") |
| pubmed:25514383 | a(CHEBI:"(-)-cotinine") increases path(MESH:Attention) |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") increases path(MESH:Attention) |
| pubmed:25514383 | a(CHEBI:"(-)-cotinine") increases bp(GO:memory) |
| pubmed:25514383 | a(CHEBI:"(-)-cotinine") decreases path(MESH:"Plaque, Amyloid") |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") decreases path(MESH:"Plaque, Amyloid") |
| pubmed:25514383 | a(CHEBI:"(-)-cotinine") increases act(p(FPLX:AKT)) |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") increases act(p(FPLX:AKT)) |
| pubmed:25514383 | a(CHEBI:"(-)-cotinine") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") increases bp(GO:"learning or memory") |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") positiveCorrelation bp(GO:"learning or memory") |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") causesNoChange path(MESH:"Tobacco Use Disorder") |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") causesNoChange path(MESH:"Tobacco Use Disorder") |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") increases a(MESH:hydroxycotinine) |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") increases a(CHEBI:"cotinine N-oxide") |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") increases a(PUBCHEM:583) |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") increases a(PUBCHEM:3398121) |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") increases a(CHEBI:Norcotinine) |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") causesNoChange path(MESH:Tachyphylaxis) |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") causesNoChange path(MESH:"Substance Withdrawal Syndrome") |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") causesNoChange path(MESH:"Cardiovascular Deconditioning") |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") positiveCorrelation bp(GO:cognition) |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") increases complex(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") increases tloc(complex(CONSO:"alpha-4 beta-2 nAChR"), fromLoc(MESH:Cytoplasm), toLoc(MESH:"Cell Membrane")) |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") decreases complex(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") increases bp(MESH:Endocytosis) |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") increases p(HGNC:DLG4) |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") decreases a(CONSO:"amyloid-beta 42 oligomers") |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") decreases act(p(HGNC:GSK3B)) |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") decreases a(CHEBI:"reactive oxygen species") |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") decreases bp(MESH:"Lipid Peroxidation") |
| pubmed:30697142 | a(CHEBI:"(-)-cotinine") isA a(CHEBI:antioxidant) |
| pubmed:28391535 | a(CHEBI:"(-)-cotinine") isA a(CHEBI:lactam) |
| pubmed:28391535 | a(CHEBI:"(-)-cotinine") association a(CHEBI:lactam) |
| pubmed:25514383 | a(CONSO:"S 24795") decreases a(CHEBI:amyloid-beta) |
| pubmed:25514383 | a(CONSO:"S 24795") increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:25514383 | a(CONSO:4-OH-GTS-21) increases path(MESH:"Spatial Memory") |
| pubmed:17640819 | a(CONSO:4-OH-GTS-21) increases path(MESH:"Spatial Memory") |
| pubmed:25514383 | a(CONSO:4-OH-GTS-21) causesNoChange bp(GO:"neuron cellular homeostasis") |
| pubmed:17640819 | a(CONSO:4-OH-GTS-21) increases path(MESH:"Avoidance Learning") |
| pubmed:17640819 | a(CONSO:4-OH-GTS-21) causesNoChange bp(GO:locomotion) |
| pubmed:17640819 | a(CONSO:4-OH-GTS-21) increases a(GO:perikaryon) |
| pubmed:17640819 | a(CONSO:4-OH-GTS-21) causesNoChange a(MESH:"Cholinergic Neurons") |
| pubmed:17640819 | a(CONSO:4-OH-GTS-21) decreases a(MESH:"Cholinergic Neurons") |
| pubmed:17640819 | a(CONSO:4-OH-GTS-21) causesNoChange a(MESH:"GABAergic Neurons") |
| pubmed:17640819 | a(CONSO:4-OH-GTS-21) causesNoChange a(CHEBI:amyloid-beta) |
| pubmed:25514383 | a(PUBCHEM:9928899) increases bp(GO:"long-term synaptic potentiation") |
| pubmed:25514383 | a(CHEBI:"pregnenolone sulfate") increases bp(GO:cognition) |
| pubmed:25514383 | a(CHEBI:"pregnenolone sulfate") increases bp(GO:"positive regulation of synaptic plasticity") |
| pubmed:25514383 | a(CHEBI:"pregnenolone sulfate") increases bp(GO:"synaptic transmission, glutamatergic") |
| pubmed:25514383 | a(CHEBI:"pregnenolone sulfate") increases path(MESH:"Spatial Memory") |
| pubmed:25514383 | a(CHEBI:"pregnenolone sulfate") decreases bp(GO:"apoptotic process") |
| pubmed:25514383 | a(CHEBI:simvastatin) regulates bp(GO:"cholesterol homeostasis") |
| pubmed:25514383 | a(CHEBI:simvastatin) increases bp(GO:cognition) |
| pubmed:25514383 | a(CHEBI:simvastatin) decreases bp(GO:"apoptotic process") |
| pubmed:29626319 | a(CHEBI:simvastatin) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | a(CHEBI:simvastatin) increases bp(GO:"ERK1 and ERK2 cascade") |
| pubmed:29626319 | a(CHEBI:simvastatin) increases tloc(p(HGNC:MME), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21718217 | bp(GO:"cholesterol homeostasis") association p(HGNC:NR1H3) |
| pubmed:25514383 | composite(a(CHEBI:simvastatin), p(MGI:App, frag("25_35"))) increases bp(GO:memory) |
| pubmed:25881725 | p(MGI:App, frag("25_35")) decreases bp(GO:learning) |
| pubmed:25881725 | p(MGI:App, frag("25_35")) decreases path(MESH:"Spatial Memory") |
| pubmed:25881725 | p(MGI:App, frag("25_35")) increases a(CONSO:"amyloid-beta oligomers", loc(GO:"extracellular region")) |
| pubmed:25881725 | p(MGI:App, frag("25_35")) causesNoChange r(MGI:Chrna7) |
| pubmed:25514383 | complex(a(CHEBI:amyloid-beta), p(FPLX:CHRN), p(HGNC:FLNA)) increases bp(GO:"intracellular signal transduction") |
| pubmed:25514383 | complex(p(HGNC:CHRNA7), p(HGNC:FLNA)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25514383 | a(CONSO:PTI-125) decreases complex(p(HGNC:CHRNA7), p(HGNC:FLNA)) |
| pubmed:25514383 | a(CONSO:PTI-125) decreases complex(a(CHEBI:amyloid-beta), p(FPLX:CHRN)) |
| pubmed:25514383 | a(CONSO:PTI-125) increases act(a(CHEBI:amyloid-beta)) |
| pubmed:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders") |
| pubmed:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders") |
| pubmed:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders") |
| pubmed:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases bp(GO:locomotion) |
| pubmed:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange path(MESH:Anxiety) |
| pubmed:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange bp(GO:"microglial cell activation") |
| pubmed:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange act(a(MESH:Neuroglia)) |
| pubmed:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange bp(GO:"inflammatory response") |
| pubmed:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(CONSO:CONSO00022) |
| pubmed:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(CONSO:CONSO00022) |
| pubmed:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(CONSO:CONSO00022) |
| pubmed:27522251 | composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases path(MESH:"Memory Disorders") |
| pubmed:27522251 | composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases path(MESH:"Memory Disorders") |
| pubmed:27522251 | composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases a(CONSO:CONSO00022) |
| pubmed:27522251 | complex(a(CHEBI:amyloid-beta), p(MGI:Chrnb2)) increases path(MESH:"Memory Disorders") |
| pubmed:27522251 | composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases path(MESH:"Memory Disorders") |
| pubmed:27522251 | composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases path(MESH:"Memory Disorders") |
| pubmed:27522251 | composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases path(MESH:"Cognitive Dysfunction") |
| pubmed:27522251 | composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases a(CONSO:CONSO00022) |
| pubmed:24762290 | a(MESH:Pons) association complex(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:24762290 | a(MESH:Mesencephalon) association complex(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:24762290 | a(MESH:"Parietal Lobe") association complex(CONSO:"alpha-4 beta-2 nAChR") |
| pubmed:30697142 | complex(a(CHEBI:acetylcholine), p(HGNC:CHRNA7)) increases bp(MESH:Neuroprotection) |
| pubmed:30697142 | a(CHEBI:nornicotine) increases path(MESH:"Tobacco Use Disorder") |
| pubmed:30697142 | a(CHEBI:nornicotine) increases act(p(HGNC:CHRNA7)) |
| pubmed:30697142 | a(CHEBI:nornicotine) increases bp(MESH:Neuroprotection) |
| pubmed:30697142 | a(CHEBI:nornicotine) decreases path(MESH:"Plaque, Amyloid") |
| pubmed:30697142 | a(CHEBI:nornicotine) decreases a(CONSO:"amyloid-beta aggregates") |
| pubmed:30697142 | a(CHEBI:nornicotine) decreases path(CONSO:neurotoxicity) |
| pubmed:30697142 | path(MESH:"Tobacco Smoking") increases bp(MESH:Metabolism) |
| pubmed:30697142 | complex(a(CHEBI:nicotine), p(HGNC:CYP2A6)) increases a(CHEBI:"(-)-cotinine") |
| pubmed:30697142 | complex(a(CHEBI:"(-)-cotinine"), p(NCIT:C18024)) increases a(CHEBI:trans-3-hydroxycotinine) |
| pubmed:30697142 | complex(a(CHEBI:"(-)-cotinine"), p(NCIT:C18024)) increases a(CHEBI:"trans-3-hydroxycotinine beta-D-glucuronide") |
| pubmed:30697142 | complex(a(CHEBI:"(-)-cotinine"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"response to nicotine") |
| pubmed:30697142 | complex(a(CHEBI:"(-)-cotinine"), p(HGNC:CHRNA7)) increases act(a(CHEBI:"(-)-cotinine")) |
| pubmed:30697142 | complex(a(CHEBI:"(-)-cotinine"), p(HGNC:CHRNA7)) increases act(p(FPLX:AKT)) |
| pubmed:30697142 | complex(a(CHEBI:"(-)-cotinine"), p(HGNC:CHRNA7)) increases act(p(FPLX:AKT)) |
| pubmed:30697142 | complex(a(CHEBI:"(-)-cotinine"), p(HGNC:CHRNA7)) increases p(HGNC:PIK3CA) |
| pubmed:30697142 | complex(a(CHEBI:"(-)-cotinine"), p(HGNC:CHRNA7)) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:30697142 | complex(a(CHEBI:"(-)-cotinine"), p(HGNC:CHRNA7)) decreases act(p(HGNC:GSK3B)) |
| pubmed:30697142 | composite(a(CHEBI:"(-)-cotinine"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases p(HGNC:TNF) |
| pubmed:30697142 | composite(a(CHEBI:"(-)-cotinine"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases p(HGNC:IL1B) |
| pubmed:30697142 | composite(a(CHEBI:"(-)-cotinine"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases p(HGNC:IL6) |
| pubmed:30697142 | composite(a(CHEBI:"(-)-cotinine"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases p(HGNC:IL10) |
| pubmed:30697142 | composite(a(CHEBI:"(-)-cotinine"), p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) increases p(HGNC:IL10) |
| pubmed:30697142 | composite(a(CHEBI:"(-)-cotinine"), p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) decreases p(HGNC:TNF) |
| pubmed:30697142 | composite(a(CHEBI:"(-)-cotinine"), p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) decreases p(HGNC:IL1B) |
| pubmed:30697142 | composite(a(CHEBI:"(-)-cotinine"), p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) decreases p(HGNC:IL6) |
| pubmed:30697142 | complex(a(CHEBI:"(-)-cotinine"), a(CHEBI:"iron cation")) decreases a(CHEBI:"reactive oxygen species") |
| pubmed:30697142 | complex(a(CHEBI:"iron cation"), a(CHEBI:nicotine)) decreases a(CHEBI:"reactive oxygen species") |
| pubmed:11230871 | bp(MESH:"Lipid Peroxidation") decreases p(FPLX:CHRN) |
| pubmed:30697142 | complex(a(CHEBI:nornicotine), p(HGNC:CHRNA7)) increases bp(GO:cognition) |
| pubmed:30697142 | complex(a(CHEBI:nornicotine), p(HGNC:CHRNA7)) increases path(MESH:Attention) |
| pubmed:21718217 | a(CONSO:CONSO00089) association bp(GO:"microglial cell activation") |
| pubmed:21718217 | a(CONSO:CONSO00089) positiveCorrelation bp(GO:"microglial cell activation") |
| pubmed:21718217 | a(CONSO:CONSO00089) increases tloc(p(HGNC:IFNG), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21718217 | a(CONSO:CONSO00089) increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21718217 | a(CONSO:CONSO00089) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21718217 | a(CONSO:CONSO00089) increases tloc(p(HGNC:IL6), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21718217 | a(CONSO:CONSO00089) increases tloc(p(HGNC:CCL2), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21718217 | act(p(HGNC:PPARG)) increases path(MESH:"Alzheimer Disease") |
| pubmed:21718217 | act(p(HGNC:PPARG)) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:21718217 | act(p(HGNC:PPARG)) increases bp(GO:"reverse cholesterol transport") |
| pubmed:21718217 | act(p(HGNC:PPARG)) decreases bp(GO:"microglial cell activation involved in immune response") |
| pubmed:21718217 | p(HGNC:PPARG) association bp(MESH:"Energy Metabolism") |
| pubmed:21718217 | p(HGNC:PPARG) increases bp(GO:"fat cell differentiation") |
| pubmed:21718217 | p(HGNC:PPARG) association bp(GO:"response to insulin") |
| pubmed:21718217 | p(HGNC:PPARG) association bp(GO:"lipid storage") |
| pubmed:21718217 | p(HGNC:PPARG) increases p(HGNC:APOE) |
| pubmed:21718217 | p(HGNC:PPARG) increases p(HGNC:ABCA1) |
| pubmed:21718217 | p(HGNC:PPARG) increases p(HGNC:NR1H3) |
| pubmed:21718217 | act(p(HGNC:PPARG)) increases p(HGNC:ARG1) |
| pubmed:21718217 | act(p(HGNC:PPARG)) increases p(HGNC:IL4) |
| pubmed:20556492 | p(HGNC:PPARG) regulates bp(GO:"lipid biosynthetic process") |
| pubmed:20556492 | p(HGNC:PPARG) regulates bp(GO:"lipid metabolic process") |
| pubmed:21718217 | act(p(HGNC:NR1H3)) increases path(MESH:"Alzheimer Disease") |
| pubmed:21718217 | act(p(HGNC:NR1H3)) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:21718217 | act(p(HGNC:NR1H3)) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:21718217 | act(p(HGNC:NR1H3)) increases bp(GO:"reverse cholesterol transport") |
| pubmed:21718217 | act(p(HGNC:NR1H3)) decreases bp(GO:"microglial cell activation involved in immune response") |
| pubmed:21718217 | p(HGNC:NR1H3) association bp(GO:"cholesterol homeostasis") |
| pubmed:21718217 | p(HGNC:NR1H3) association bp(GO:"negative regulation of inflammatory response") |
| pubmed:21718217 | p(HGNC:NR1H3) increases p(HGNC:APOE) |
| pubmed:21718217 | act(p(HGNC:NR1H3)) increases act(p(HGNC:APOE)) |
| pubmed:21718217 | p(HGNC:NR1H3) increases p(HGNC:ABCA1) |
| pubmed:21718217 | act(p(HGNC:NR1H3)) increases bp(GO:memory) |
| pubmed:21718217 | act(p(HGNC:NR1H3)) decreases bp(GO:"microglial cell activation") |
| pubmed:21718217 | p(FPLX:PPAR) association bp(MESH:"Energy Metabolism") |
| pubmed:21718217 | p(FPLX:PPAR) positiveCorrelation bp(MESH:"Energy Metabolism") |
| pubmed:21718217 | p(FPLX:PPAR) association bp(GO:"fat cell differentiation") |
| pubmed:21718217 | p(FPLX:PPAR) positiveCorrelation bp(GO:"fat cell differentiation") |
| pubmed:21718217 | p(FPLX:PPAR) association bp(GO:"response to insulin") |
| pubmed:21718217 | p(FPLX:PPAR) positiveCorrelation bp(GO:"response to insulin") |
| pubmed:21718217 | p(FPLX:PPAR) association bp(GO:"response to tumor cell") |
| pubmed:21718217 | p(FPLX:PPAR) positiveCorrelation bp(GO:"response to tumor cell") |
| pubmed:21718217 | p(FPLX:PPAR) regulates bp(GO:"lipid metabolic process") |
| pubmed:21718217 | act(p(FPLX:PPAR)) decreases bp(GO:"microglial cell activation") |
| pubmed:21718217 | act(p(FPLX:RXR)) increases p(HGNC:APOE) |
| pubmed:21718217 | act(p(FPLX:RXR)) increases p(HGNC:ABCA1) |
| pubmed:21718217 | bp(GO:"fat cell differentiation") association p(FPLX:PPAR) |
| pubmed:21718217 | bp(GO:"fat cell differentiation") positiveCorrelation p(FPLX:PPAR) |
| pubmed:21718217 | bp(GO:"response to insulin") association p(FPLX:PPAR) |
| pubmed:21718217 | bp(GO:"response to insulin") positiveCorrelation p(FPLX:PPAR) |
| pubmed:21718217 | bp(GO:"response to insulin") association p(HGNC:PPARG) |
| pubmed:21718217 | bp(GO:"response to tumor cell") association p(FPLX:PPAR) |
| pubmed:21718217 | bp(GO:"response to tumor cell") positiveCorrelation p(FPLX:PPAR) |
| pubmed:30688256 | bp(GO:"lipid oxidation") association bp(GO:mitophagy) |
| pubmed:27299292 | bp(GO:"lipid oxidation") positiveCorrelation p(HGNC:TFEB) |
| pubmed:21718217 | bp(GO:"lipid storage") association p(HGNC:PPARG) |
| pubmed:21718217 | p(HGNC:PPARD) association bp(GO:"fatty acid oxidation") |
| pubmed:21718217 | act(p(HGNC:PPARD)) increases bp(GO:"reverse cholesterol transport") |
| pubmed:21718217 | act(p(HGNC:PPARD)) increases bp(GO:"negative regulation of inflammatory response") |
| pubmed:21718217 | act(p(HGNC:PPARD)) increases p(HGNC:ARG1) |
| pubmed:21718217 | act(p(HGNC:PPARD)) increases p(HGNC:IL4) |
| pubmed:21718217 | bp(GO:"fatty acid oxidation") association p(HGNC:PPARD) |
| pubmed:21718217 | a(CHEBI:oxysterol) increases act(p(HGNC:NR1H3)) |
| pubmed:21718217 | a(CHEBI:oxysterol) increases act(p(HGNC:NR1H3)) |
| pubmed:21718217 | bp(GO:"negative regulation of inflammatory response") association p(HGNC:NR1H3) |
| pubmed:21718217 | p(HGNC:ABCA1) increases p(HGNC:APOE) |
| pubmed:21718217 | p(HGNC:ABCA1) decreases a(CONSO:CONSO00018) |
| pubmed:21718217 | a(CHEBI:"GW 3965") directlyIncreases act(p(HGNC:NR1H3)) |
| pubmed:21718217 | a(CHEBI:"GW 3965") increases act(p(HGNC:NR1H3)) |
| pubmed:21718217 | a(CHEBI:"GW 3965") increases p(HGNC:APOE) |
| pubmed:21718217 | a(CHEBI:"GW 3965") increases p(HGNC:ABCA1) |
| pubmed:21718217 | a(CHEBI:"GW 3965") decreases a(CONSO:CONSO00018) |
| pubmed:21718217 | a(CHEBI:"GW 3965") increases bp(GO:memory) |
| pubmed:21718217 | a(CHEBI:"GW 3965") decreases path(MESH:Inflammation) |
| pubmed:21718217 | a(CHEBI:"GW 3965") increases act(a(CONSO:CONSO00038)) |
| pubmed:21718217 | a(CHEBI:"GW 3965") increases bp(GO:phagocytosis) |
| pubmed:21718217 | p(MGI:Abca1) decreases a(CHEBI:amyloid-beta) |
| pubmed:21718217 | p(MGI:Abca1) decreases a(CONSO:CONSO00038) |
| pubmed:21718217 | a(CHEBI:pioglitazone) increases act(p(HGNC:PPARG)) |
| pubmed:21718217 | a(CHEBI:pioglitazone) decreases path(MESH:"Diabetes Mellitus, Type 2") |
| pubmed:21718217 | a(CHEBI:pioglitazone) decreases a(CONSO:CONSO00018) |
| pubmed:21718217 | a(CHEBI:pioglitazone) decreases a(CONSO:CONSO00018) |
| pubmed:21718217 | a(CHEBI:pioglitazone) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:21718217 | a(CHEBI:pioglitazone) increases bp(GO:behavior) |
| pubmed:21718217 | a(CHEBI:pioglitazone) increases p(MGI:Abca1) |
| pubmed:21718217 | a(CHEBI:pioglitazone) increases p(MGI:Apoe) |
| pubmed:21718217 | a(CHEBI:pioglitazone) increases bp(GO:memory) |
| pubmed:21718217 | a(CHEBI:pioglitazone) increases bp(GO:cognition) |
| pubmed:29626319 | a(CHEBI:pioglitazone) decreases a(CHEBI:amyloid-beta) |
| pubmed:21718217 | a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG)) |
| pubmed:21718217 | a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG)) |
| pubmed:20556492 | a(CHEBI:rosiglitazone) increases p(HGNC:PPARG) |
| pubmed:29626319 | a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG)) |
| pubmed:21718217 | a(CHEBI:rosiglitazone) decreases path(MESH:"Diabetes Mellitus, Type 2") |
| pubmed:21718217 | a(CHEBI:rosiglitazone) increases bp(GO:behavior) |
| pubmed:21718217 | a(CHEBI:rosiglitazone) causesNoChange a(CONSO:CONSO00018) |
| pubmed:21718217 | a(CHEBI:rosiglitazone) decreases a(CONSO:CONSO00018) |
| pubmed:21718217 | a(CHEBI:rosiglitazone) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:21718217 | a(CHEBI:rosiglitazone) decreases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | a(CHEBI:rosiglitazone) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:21718217 | a(CHEBI:rosiglitazone) increases bp(GO:"learning or memory") |
| pubmed:21718217 | a(CHEBI:rosiglitazone) increases p(MGI:Ctnnb1) |
| pubmed:21718217 | a(CHEBI:rosiglitazone) decreases p(MGI:Gsk3b) |
| pubmed:21718217 | a(CHEBI:rosiglitazone) increases p(MGI:Abca1) |
| pubmed:21718217 | a(CHEBI:rosiglitazone) increases bp(GO:memory) |
| pubmed:21718217 | a(CHEBI:rosiglitazone) increases bp(GO:cognition) |
| pubmed:20556492 | a(CHEBI:rosiglitazone) decreases act(a(CHEBI:thapsigargin)) |
| pubmed:20556492 | a(CHEBI:rosiglitazone) increases bp(GO:"regulation of membrane potential") |
| pubmed:20556492 | a(CHEBI:rosiglitazone) decreases path(HP:"Increased reactive oxygen species production") |
| pubmed:29626319 | a(CHEBI:rosiglitazone) increases p(HGNC:CD36) |
| pubmed:29626319 | a(CHEBI:rosiglitazone) increases act(a(MESH:Microglia)) |
| pubmed:22798221 | act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:22798221 | act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 198)) |
| pubmed:22798221 | act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:22798221 | act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:22798221 | act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:22798221 | act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:22798221 | act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:22798221 | act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) |
| pubmed:29121589 | act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Dpysl2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29121589 | act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21718217 | a(CHEBI:"GW 501516") increases act(p(HGNC:PPARD)) |
| pubmed:21718217 | a(CHEBI:"GW 501516") increases p(HGNC:ABCA1) |
| pubmed:21718217 | a(CHEBI:"GW 501516") increases p(HGNC:APOA1) |
| pubmed:21718217 | a(CHEBI:"GW 501516") decreases a(CONSO:CONSO00018) |
| pubmed:21718217 | a(CHEBI:"GW 501516") increases p(HGNC:MME) |
| pubmed:21718217 | a(CHEBI:"GW 501516") increases p(HGNC:IDE) |
| pubmed:21718217 | a(CHEBI:"all-trans-retinoic acid") increases act(p(FPLX:RXR)) |
| pubmed:21718217 | a(CHEBI:"all-trans-retinoic acid") increases act(p(FPLX:RAR)) |
| pubmed:21718217 | a(CHEBI:"all-trans-retinoic acid") decreases a(CONSO:CONSO00018) |
| pubmed:21718217 | a(CHEBI:"all-trans-retinoic acid") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21718217 | a(CHEBI:"all-trans-retinoic acid") increases bp(GO:memory) |
| pubmed:26400044 | a(CHEBI:"all-trans-retinoic acid") decreases path(MESH:"Plaque, Amyloid") |
| pubmed:26400044 | a(CHEBI:"all-trans-retinoic acid") decreases bp(CONSO:"APP processing") |
| pubmed:26400044 | a(CHEBI:"all-trans-retinoic acid") decreases a(CHEBI:amyloid-beta) |
| pubmed:26400044 | a(CHEBI:"all-trans-retinoic acid") decreases act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) |
| pubmed:26400044 | a(CHEBI:"all-trans-retinoic acid") decreases act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) |
| pubmed:26400044 | a(CHEBI:"all-trans-retinoic acid") decreases a(CONSO:"Tau aggregates") |
| pubmed:26400044 | a(CHEBI:"all-trans-retinoic acid") decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27181519 | a(CHEBI:"all-trans-retinoic acid") association bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") |
| pubmed:27181519 | a(CHEBI:"all-trans-retinoic acid") association bp(GO:autophagy) |
| pubmed:27181519 | a(CHEBI:"all-trans-retinoic acid") negativeCorrelation path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:21718217 | a(CHEBI:bexarotene) increases act(p(FPLX:RXR)) |
| pubmed:21718217 | a(CHEBI:bexarotene) increases p(HGNC:APOE) |
| pubmed:21718217 | a(CHEBI:bexarotene) increases p(HGNC:ABCA1) |
| pubmed:21718217 | a(CHEBI:bexarotene) decreases a(CONSO:CONSO00018) |
| pubmed:21718217 | a(CHEBI:bexarotene) increases bp(GO:behavior) |
| pubmed:27181519 | a(CHEBI:bexarotene) isA a(CHEBI:"retinoid X receptor agonist") |
| pubmed:27181519 | a(CHEBI:bexarotene) decreases path(MESH:"Motor Neuron Disease") |
| pubmed:27181519 | a(CHEBI:bexarotene) decreases path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:21718217 | a(CHEBI:Honokiol) increases act(p(FPLX:RXR)) |
| pubmed:21718217 | a(CHEBI:Honokiol) increases act(complex(p(FPLX:RXR), p(HGNC:NR1H3))) |
| pubmed:21718217 | a(CHEBI:Honokiol) increases p(HGNC:APOE) |
| pubmed:21718217 | a(CHEBI:Honokiol) increases p(HGNC:ABCA1) |
| pubmed:21718217 | r(HGNC:ARG1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:28445721 | path(MESH:Motivation) association p(FPLX:CHRN) |
| pubmed:30985105 | bp(GO:"dopamine secretion") association p(HGNC:SNCA) |
| pubmed:30985105 | bp(GO:"dopamine secretion") association bp(GO:"musculoskeletal movement") |
| pubmed:28445721 | bp(MESH:"Physiological Phenomena") association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pubmed:28445721 | p(HGNC:TMEM35A) regulates act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:28445721 | act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) regulates tloc(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) |
| pubmed:28445721 | act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) regulates a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pubmed:28445721 | act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:28445721 | act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases tloc(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) |
| pubmed:28445721 | act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pubmed:28445721 | act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pubmed:28445721 | act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases tloc(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) |
| pubmed:28445721 | p(HGNC:TMEM35A) causesNoChange act(p(FPLX:GABR)) |
| pubmed:28445721 | p(HGNC:TMEM35A) causesNoChange act(a(MESH:"Receptors, Serotonin")) |
| pubmed:28445721 | p(HGNC:TMEM35A) causesNoChange act(p(HGNC:TRPV1)) |
| pubmed:28445721 | p(HGNC:TMEM35A) causesNoChange act(a(MESH:"Receptors, Glutamate")) |
| pubmed:28445721 | act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases act(p(CONSO:CONSO00174)) |
| pubmed:28445721 | act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases tloc(p(CONSO:CONSO00174), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) |
| pubmed:28445721 | act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases p(CONSO:CONSO00174) |
| pubmed:28445721 | act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases act(a(MESH:"nicotinic receptor alpha3beta2")) |
| pubmed:28445721 | act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases tloc(a(MESH:"nicotinic receptor alpha3beta2"), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) |
| pubmed:28445721 | act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases a(MESH:"nicotinic receptor alpha3beta2") |
| pubmed:28445721 | act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases act(a(MESH:"nicotinic receptor alpha3beta4")) |
| pubmed:28445721 | act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases tloc(a(MESH:"nicotinic receptor alpha3beta4"), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) |
| pubmed:28445721 | act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases a(MESH:"nicotinic receptor alpha3beta4") |
| pubmed:28445721 | act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:28445721 | act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta2")) |
| pubmed:28445721 | act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases complex(a(CHEBI:epibatidine), p(CONSO:CONSO00174)) |
| pubmed:28445721 | act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta4")) |
| pubmed:28445721 | p(HGNC:TMEM35A) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) |
| pubmed:28445721 | p(HGNC:TMEM35A) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) |
| pubmed:28445721 | p(HGNC:TMEM35A) increases a(MESH:"alpha6beta2 nicotinic acetylcholine receptor") |
| pubmed:28445721 | act(p(MGI:Tmem35a), ma(go:0044183 ! "protein binding involved in protein folding")) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pubmed:28445721 | p(MGI:Tmem35a) association p(MGI:Canx) |
| pubmed:28445721 | p(MGI:Tmem35a) increases complex(a(MESH:Bungarotoxins), p(FPLX:CHRN)) |
| pubmed:28445721 | p(MGI:Tmem35a) increases complex(a(CHEBI:epibatidine), p(CONSO:CONSO00180)) |
| pubmed:28445721 | p(MGI:Tmem35a) increases complex(a(CHEBI:epibatidine), p(CONSO:CONSO00174)) |
| pubmed:28445721 | p(MGI:Tmem35a) increases p(CONSO:CONSO00180) |
| pubmed:28445721 | p(MGI:Tmem35a) increases complex(a(MESH:Bungarotoxins), loc(GO:membrane)) |
| pubmed:28445721 | p(MGI:Tmem35a) increases p(FPLX:CHRN) |
| pubmed:28445721 | p(MGI:Tmem35a) regulates p(FPLX:CHRN) |
| pubmed:28445721 | p(MGI:Tmem35a) increases a(MESH:"nicotinic receptor alpha3beta4") |
| pubmed:28445721 | p(MGI:Tmem35a) decreases bp(GO:locomotion) |
| pubmed:28445721 | p(MGI:Tmem35a) decreases bp(GO:locomotion) |
| pubmed:28445721 | p(MGI:Tmem35a) association bp(GO:"temperature homeostasis") |
| pubmed:28445721 | p(MGI:Tmem35a) increases bp(GO:learning) |
| pubmed:28445721 | p(MGI:Tmem35a) increases bp(GO:memory) |
| pubmed:28445721 | p(MGI:Tmem35a) increases path(MESH:"Spatial Learning") |
| pubmed:28445721 | p(MGI:Tmem35a) increases path(MESH:"Spatial Memory") |
| pubmed:11230871 | complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) negativeCorrelation bp(GO:aging) |
| pubmed:11230871 | complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) negativeCorrelation bp(GO:aging) |
| pubmed:28445721 | composite(p(HGNC:RIC3), p(HGNC:TMEM35A)) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:28445721 | composite(p(HGNC:RIC3), p(HGNC:TMEM35A)) increases complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta2")) |
| pubmed:28445721 | composite(a(MESH:Bungarotoxins), p(HGNC:TMEM35A)) decreases complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:28445721 | p(MGI:Canx) association p(MGI:Tmem35a) |
| pubmed:28445721 | composite(a(CHEBI:nicotine), p(HGNC:TMEM35A)) increases p(CONSO:CONSO00174) |
| pubmed:18174175 | complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) increases act(a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) |
| pubmed:21787755 | a(MESH:"alpha6beta2 nicotinic acetylcholine receptor") regulates tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28445721 | a(MESH:"alpha-conotoxin MII") decreases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) |
| pubmed:21787755 | a(MESH:"alpha-conotoxin MII") decreases act(p(CONSO:"alpha-3 beta-2 nAChR")) |
| pubmed:28445721 | bp(GO:"temperature homeostasis") association p(MGI:Tmem35a) |
| pubmed:21482353 | p(HGNC:CHRNA4, var("?")) positiveCorrelation path(MESH:Epilepsy) |
| pubmed:21482353 | p(HGNC:CHRNA4, var("?")) increases path(CONSO:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") |
| pubmed:21482353 | p(HGNC:CHRNB2, var("?")) positiveCorrelation path(MESH:Epilepsy) |
| pubmed:21482353 | p(HGNC:CHRNB2, var("?")) increases path(CONSO:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") |
| pubmed:21482353 | p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") |
| pubmed:21482353 | p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") |
| pubmed:21482353 | p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:Alcoholism) |
| pubmed:21482353 | p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Cocaine-Related Disorders") |
| pubmed:21482353 | p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Opioid-Related Disorders") |
| pubmed:21482353 | p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms") |
| pubmed:21482353 | p(HGNC:CHRNA5, var("?")) positiveCorrelation bp(GO:cognition) |
| pubmed:21482353 | complex(p(FPLX:CHRN), p(HGNC:RIC3)) increases p(FPLX:CHRN) |
| pubmed:21482353 | complex(p(FPLX:CHRN), p(HGNC:RIC3)) increases act(p(FPLX:CHRN)) |
| pubmed:21482353 | complex(a(INTERPRO:"14-3-3 protein"), p(FPLX:CHRN)) increases p(FPLX:CHRN) |
| pubmed:21482353 | complex(a(INTERPRO:"14-3-3 protein"), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) |
| pubmed:21482353 | complex(p(FPLX:CHRN), p(INTERPRO:Neurexin)) increases p(FPLX:CHRN) |
| pubmed:21482353 | complex(p(FPLX:CHRN), p(INTERPRO:Neurexin)) increases act(p(FPLX:CHRN)) |
| pubmed:21482353 | complex(p(FPLX:CHRN), p(HGNC:VSNL1)) increases p(FPLX:CHRN) |
| pubmed:21482353 | complex(p(FPLX:CHRN), p(HGNC:VSNL1)) increases act(p(FPLX:CHRN)) |
| pubmed:19721446 | p(HGNC:VSNL1) association p(HGNC:CHRNA4, frag("331_600")) |
| pubmed:21482353 | complex(p(FPLX:CHRN), p(HGNC:LYNX1)) regulates act(p(FPLX:CHRN)) |
| pubmed:21482353 | complex(p(FPLX:CHRN), p(HGNC:LYNX1)) association act(p(FPLX:CHRN)) |
| pubmed:21482353 | complex(p(FPLX:CHRN), p(HGNC:LYNX1)) association tloc(p(FPLX:CHRN), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) |
| pubmed:21482353 | composite(p(CONSO:"alpha-4 beta-2 nAChR"), p(HGNC:LYNX1)) decreases act(p(FPLX:CHRN)) |
| pubmed:21482353 | complex(p(CONSO:"alpha-4 beta-2 nAChR"), p(HGNC:LYNX1)) regulates act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:21482353 | complex(p(HGNC:CHRNA3), p(HGNC:LYNX1)) regulates act(p(HGNC:CHRNA3)) |
| pubmed:21482353 | complex(p(CONSO:"alpha-7-containing nAChR"), p(HGNC:LYNX1)) regulates act(p(CONSO:"alpha-7-containing nAChR")) |
| pubmed:21482353 | p(MGI:Lynx1) decreases a(CHEBI:"calcium(2+)") |
| pubmed:21482353 | p(MGI:Lynx1) decreases bp(MESH:"Synaptic Transmission") |
| pubmed:21482353 | p(MGI:Lynx1) decreases bp(GO:learning) |
| pubmed:21482353 | p(MGI:Lynx1) decreases bp(GO:memory) |
| pubmed:21482353 | p(MGI:Lynx1) decreases bp(MESH:"Dominance, Ocular") |
| pubmed:21482353 | p(MGI:Lynx1) decreases bp(GO:"synaptic transmission, cholinergic") |
| pubmed:21482353 | p(MGI:Lynx1) increases a(MESH:Neurons) |
| pubmed:21482353 | p(MGI:Slc12a2) increases act(p(MGI:Lynx1)) |
| pubmed:21482353 | p(FPLX:ADCY, var("?")) decreases act(p(MGI:Lynx1)) |
| pubmed:21482353 | p(HGNC:PSCA) decreases bp(GO:"programmed cell death") |
| pubmed:21482353 | bp(GO:"synapse maturation") negativeCorrelation p(HGNC:LYNX1) |
| pubmed:21482353 | bp(GO:"GABAergic neuron differentiation") association path(MESH:Schizophrenia) |
| pubmed:21482353 | bp(GO:"GABAergic neuron differentiation") association path(MESH:Amblyopia) |
| pubmed:21482353 | path(MESH:Amblyopia) association bp(GO:"GABAergic neuron differentiation") |
| pubmed:21482353 | a(HP:"inhibitory interneuron") regulates bp(GO:"sensory processing") |
| pubmed:21482353 | act(a(HP:"inhibitory interneuron")) increases act(p(FPLX:NOS)) |
| pubmed:21482353 | a(HP:"inhibitory interneuron") association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pubmed:21482353 | act(a(HP:"inhibitory interneuron")) negativeCorrelation g(HGNC:CHRFAM7A, var("?")) |
| pubmed:24563850 | act(p(FPLX:NOS)) increases a(CHEBI:radical) |
| pubmed:24563850 | act(p(FPLX:NOS)) increases a(CHEBI:"reactive oxygen species") |
| pubmed:21482353 | a(MESH:"Brain Stem") regulates act(a(MESH:Hippocampus)) |
| pubmed:21482353 | g(HGNC:CHRFAM7A, var("?")) association path(MESH:Schizophrenia) |
| pubmed:21482353 | g(HGNC:CHRFAM7A, var("?")) negativeCorrelation act(a(HP:"inhibitory interneuron")) |
| pubmed:21482353 | a(CONSO:GTS-21) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:21482353 | a(CONSO:GTS-21) increases path(MESH:Attention) |
| pubmed:21482353 | a(CONSO:GTS-21) increases bp(GO:"sensory processing") |
| pubmed:21482353 | a(CONSO:GTS-21) decreases path(MESH:Anhedonia) |
| pubmed:21482353 | a(CONSO:GTS-21) decreases path(MESH:Aphasia) |
| pubmed:21482353 | p(HGNC:SLC12A5) decreases a(CHEBI:chloride) |
| pubmed:21482353 | p(HGNC:SLC12A5) regulates act(a(CHEBI:"gamma-aminobutyric acid")) |
| pubmed:21482353 | p(HGNC:PEMT) increases a(CHEBI:phosphatidylcholine) |
| pubmed:21482353 | a(CHEBI:phosphatidylcholine) increases a(CHEBI:choline) |
| pubmed:21482353 | p(HGNC:PEMT, var("?")) association path(MESH:"Choline Deficiency") |
| pubmed:21482353 | p(HGNC:PEMT, var("?")) association path(MESH:Schizophrenia) |
| pubmed:21482353 | path(MESH:"Choline Deficiency") association p(HGNC:PEMT, var("?")) |
| pubmed:21482353 | bp(GO:"response to cytokine") association p(CONSO:"alpha-7-containing nAChR") |
| pubmed:21482353 | bp(MESH:"Stress, Physiological") increases a(CHEBI:dopamine) |
| pubmed:27299292 | bp(MESH:"Stress, Physiological") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) |
| pubmed:23746257 | bp(MESH:"Stress, Physiological") increases a(MESH:"Heat-Shock Proteins") |
| pubmed:25784053 | bp(MESH:"Stress, Physiological") regulates bp(CONSO:Proteostasis) |
| pubmed:21482353 | path(MESH:"Cocaine-Related Disorders") positiveCorrelation p(HGNC:CHRNA5, var("?")) |
| pubmed:21482353 | path(MESH:"Cocaine-Related Disorders") positiveCorrelation p(HGNC:CHRNA3, var("?")) |
| pubmed:21482353 | path(MESH:"Cocaine-Related Disorders") positiveCorrelation p(HGNC:CHRNB4, var("?")) |
| pubmed:21482353 | path(MESH:"Opioid-Related Disorders") positiveCorrelation p(HGNC:CHRNA5, var("?")) |
| pubmed:21482353 | path(MESH:"Opioid-Related Disorders") positiveCorrelation p(HGNC:CHRNA3, var("?")) |
| pubmed:21482353 | path(MESH:"Opioid-Related Disorders") positiveCorrelation p(HGNC:CHRNB4, var("?")) |
| pubmed:21482353 | path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNA5, var("?")) |
| pubmed:21482353 | path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNA3, var("?")) |
| pubmed:21482353 | path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNB4, var("?")) |
| pubmed:19721446 | path(MESH:"Lung Neoplasms") association g(HGNC:CHRNA5) |
| pubmed:19721446 | path(MESH:"Lung Neoplasms") association g(HGNC:CHRNA3) |
| pubmed:19721446 | path(MESH:"Lung Neoplasms") association g(HGNC:CHRNB4) |
| pubmed:28901280 | path(MESH:"Lung Neoplasms") association g(DBSNP:rs1051730) |
| pubmed:28901280 | path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA9) |
| pubmed:28901280 | path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA5) |
| pubmed:28901280 | path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA10) |
| pubmed:21482353 | p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") |
| pubmed:21482353 | p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:Alcoholism) |
| pubmed:21482353 | p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Cocaine-Related Disorders") |
| pubmed:21482353 | p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Opioid-Related Disorders") |
| pubmed:21482353 | p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms") |
| pubmed:21482353 | p(HGNC:CHRNA3, var("?")) positiveCorrelation bp(GO:cognition) |
| pubmed:21482353 | p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") |
| pubmed:21482353 | p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:Alcoholism) |
| pubmed:21482353 | p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Cocaine-Related Disorders") |
| pubmed:21482353 | p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Opioid-Related Disorders") |
| pubmed:21482353 | p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms") |
| pubmed:21482353 | p(HGNC:CHRNB4, var("?")) positiveCorrelation bp(GO:cognition) |
| pubmed:18986241 | path(MESH:"Behavioral Symptoms") association path(MESH:"Alzheimer Disease") |
| pubmed:18986241 | path(CONSO:aMCI) association path(MESH:"Memory Disorders") |
| pubmed:18986241 | path(CONSO:aMCI) association path(MESH:Dementia) |
| pubmed:18986241 | path(CONSO:aMCI) association path(MESH:"Alzheimer Disease") |
| pubmed:18986241 | path(CONSO:mdMCI) association path(MESH:"Cognitive Dysfunction") |
| pubmed:18986241 | path(MESH:"Prodromal Symptoms") association path(MESH:"Cognitive Dysfunction") |
| pubmed:18986241 | path(MESH:"Cholinergic Neurons") directlyIncreases bp(GO:innervation) |
| pubmed:18986241 | path(MESH:"Cholinergic Neurons") association path(MESH:Memory) |
| pubmed:18986241 | path(MESH:"Cholinergic Neurons") association path(MESH:Attention) |
| pubmed:18986241 | path(MESH:"Cholinergic Neurons") association a(MESH:"Neurofibrillary Tangles") |
| pubmed:18986241 | path(MESH:"Cholinergic Neurons") association path(MESH:"Alzheimer Disease") |
| pubmed:18986241 | path(MESH:"Cholinergic Neurons") association a(MESH:Neuropeptides) |
| pubmed:18986241 | path(MESH:"Cholinergic Neurons") association a(MESH:"GABAergic Neurons") |
| pubmed:18986241 | path(MESH:"Cholinergic Neurons") association p(RGD:Gal) |
| pubmed:18986241 | path(MESH:"Cholinergic Neurons") association path(MESH:"Memory, Short-Term") |
| pubmed:18986241 | path(MESH:"Cholinergic Neurons") association path(MESH:Dementia) |
| pubmed:18986241 | bp(GO:innervation) association p(HGNC:NGF) |
| pubmed:18986241 | a(MESH:Neuropeptides) association path(MESH:"Cholinergic Neurons") |
| pubmed:18986241 | p(RGD:Gal) association path(MESH:"Cholinergic Neurons") |
| pubmed:18986241 | a(MESH:"Frontal Lobe") positiveCorrelation path(MESH:"Psychomotor Performance") |
| pubmed:28669544 | a(MESH:"Frontal Lobe") negativeCorrelation path(OMIT:0026893) |
| pubmed:18986241 | p(HGNC:BCHE, var("p.Ala539Thr")) decreases p(HGNC:BCHE) |
| pubmed:18986241 | p(HGNC:BCHE, var("p.Ala539Thr")) association path(MESH:"Cognitive Dysfunction") |
| pubmed:18986241 | complex(p(HGNC:NGF), p(HGNC:NTRK1)) increases bp(GO:"nerve growth factor signaling pathway") |
| pubmed:18986241 | complex(p(HGNC:NGF), p(HGNC:NTRK1)) increases bp(GO:"neuron projection development") |
| pubmed:18986241 | bp(GO:"nerve growth factor signaling pathway") increases bp(GO:"response to nerve growth factor") |
| pubmed:18986241 | bp(GO:"regulation of neuron death") association p(HGNC:NGFR) |
| pubmed:18986241 | a(MESH:"pro-nerve growth factor, human") positiveCorrelation path(MESH:"Cognition Disorders") |
| pubmed:18986241 | a(MESH:"pro-nerve growth factor, human") biomarkerFor path(MESH:"Alzheimer Disease") |
| pubmed:18986241 | complex(a(MESH:"pro-nerve growth factor, human"), p(HGNC:NTRK1)) increases bp(GO:"neuron projection development") |
| pubmed:18986241 | complex(a(MESH:"pro-nerve growth factor, human"), p(HGNC:NGFR)) increases bp(GO:"apoptotic process") |
| pubmed:18986241 | composite(a(MESH:"pro-nerve growth factor, human"), complex(p(HGNC:NGFR), p(HGNC:SORT1))) increases bp(GO:"apoptotic process") |
| pubmed:18986241 | p(HGNC:SORT1) association path(MESH:"Alzheimer Disease") |
| pubmed:18986241 | act(p(HGNC:MMP9)) positiveCorrelation path(MESH:"Cognition Disorders") |
| pubmed:27594586 | p(HGNC:MMP9) increases p(HGNC:HTT, frag("?")) |
| pubmed:27594586 | act(p(HGNC:MMP9)) association path(MESH:"Neurodevelopmental Disorders") |
| pubmed:27594586 | act(p(HGNC:MMP9)) increases bp(GO:"neuron death") |
| pubmed:27594586 | p(HGNC:MMP9) increases bp(GO:"neuron death") |
| pubmed:27594586 | act(p(HGNC:MMP9)) positiveCorrelation p(FPLX:ERK, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27594586 | tloc(p(HGNC:MMP9), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) positiveCorrelation p(FPLX:ERK, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26195256 | p(HGNC:MMP9) increases deg(a(CHEBI:amyloid-beta, loc(GO:"extracellular region"))) |
| pubmed:29626319 | act(p(HGNC:MMP9)) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | p(HGNC:MMP9) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:18986241 | g(HGNC:NTRK1) association path(MESH:Cognition) |
| pubmed:18986241 | g(HGNC:NTRK2) association path(MESH:Cognition) |
| pubmed:27013968 | g(HGNC:NTRK2) increases p(HGNC:NTRK2) |
| pubmed:18986241 | g(HGNC:NTRK3) association path(MESH:Cognition) |
| pubmed:18986241 | act(p(HGNC:MAPKAPK2)) increases p(HGNC:ELK1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:18986241 | act(p(HGNC:MAPKAPK2)) increases p(HGNC:CREB1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:18986241 | p(HGNC:IRS1) association bp(GO:"phosphatidylinositol 3-kinase signaling") |
| pubmed:18986241 | p(HGNC:IRS1) association bp(GO:"protein kinase B signaling") |
| pubmed:18986241 | p(HGNC:GAB1) association bp(GO:"phosphatidylinositol 3-kinase signaling") |
| pubmed:18986241 | p(HGNC:GAB1) association bp(GO:"protein kinase B signaling") |
| pubmed:18986241 | act(p(HGNC:PLCG1)) association bp(MESH:"Oxidative Stress") |
| pubmed:18467332 | p(HGNC:PLCG1) isA complex(p(HGNC:MAPT), p(HGNC:PLCG1)) |
| pubmed:18986241 | complex(a(MESH:"gambogic amide"), p(HGNC:NTRK1)) directlyIncreases p(HGNC:NTRK1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:18986241 | a(MESH:"gambogic amide") decreases path(CONSO:Excitotoxicity) |
| pubmed:18986241 | a(MESH:"gambogic amide") increases bp(GO:"neuron projection development") |
| pubmed:18986241 | p(HGNC:NTRK1, pmod(go:0006468 ! "protein phosphorylation")) increases bp(GO:"protein kinase B signaling") |
| pubmed:18986241 | p(HGNC:NTRK1, pmod(go:0006468 ! "protein phosphorylation")) increases bp(GO:"MAPK cascade") |
| pubmed:18986241 | path(MESH:Amyloidosis) association p(HGNC:CHRM1) |
| pubmed:26751493 | r(HGNC:SYP) negativeCorrelation a(GO:"neurofibrillary tangle") |
| pubmed:18986241 | p(HGNCGENEFAMILY:Synaptotagmins) association bp(GO:"synaptic vesicle fusion to presynaptic active zone membrane") |
| pubmed:18986241 | p(HGNCGENEFAMILY:Synaptotagmins) association bp(GO:"neurotransmitter secretion") |
| pubmed:18986241 | bp(GO:"synaptic vesicle fusion to presynaptic active zone membrane") association p(HGNCGENEFAMILY:Synaptotagmins) |
| pubmed:27574109 | p(CONSO:"Tau isoform B (381 aa)") increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | p(CONSO:"Tau isoform B (381 aa)") positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:17493042 | p(CONSO:"Tau isoform B (381 aa)") partOf a(MESH:Brain) |
| pubmed:23407988 | p(CONSO:"Tau isoform B (381 aa)") isA p(CONSO:"3R tau") |
| pubmed:28148553 | p(CONSO:"Tau isoform C (410 aa)") directlyIncreases p(CONSO:"3R tau") |
| pubmed:23407988 | p(CONSO:"Tau isoform C (410 aa)") isA p(CONSO:"3R tau") |
| pubmed:28148553 | p(CONSO:"Tau isoform C (410 aa)") causesNoChange p(HGNC:EIF2AK3) |
| pubmed:28148553 | p(CONSO:"Tau isoform C (410 aa)") causesNoChange p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | p(CONSO:"Tau isoform C (410 aa)") causesNoChange p(HGNC:EIF2A) |
| pubmed:27574109 | p(CONSO:"Tau isoform C (410 aa)") association p(CONSO:"phosphatase-activating domain") |
| pubmed:27574109 | p(CONSO:"Tau isoform C (410 aa)") positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:27574109 | p(CONSO:"Tau isoform C (410 aa)") increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | p(CONSO:"Tau isoform C (410 aa)") increases a(CONSO:"Tau oligomers") |
| pubmed:17493042 | p(CONSO:"Tau isoform C (410 aa)") partOf a(MESH:Brain) |
| pubmed:27574109 | p(CONSO:"Tau isoform D (383 aa)") association p(CONSO:"phosphatase-activating domain") |
| pubmed:27574109 | p(CONSO:"Tau isoform D (383 aa)") positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:27574109 | p(CONSO:"Tau isoform D (383 aa)") increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | p(CONSO:"Tau isoform D (383 aa)") increases a(CONSO:"Tau oligomers") |
| pubmed:17493042 | p(CONSO:"Tau isoform D (383 aa)") partOf a(MESH:Brain) |
| pubmed:23407988 | p(CONSO:"Tau isoform D (383 aa)") isA p(CONSO:"4R tau") |
| pubmed:27574109 | p(CONSO:"Tau isoform E (412 aa)") increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | p(CONSO:"Tau isoform E (412 aa)") positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:17493042 | p(CONSO:"Tau isoform E (412 aa)") partOf a(MESH:Brain) |
| pubmed:23407988 | p(CONSO:"Tau isoform E (412 aa)") isA p(CONSO:"4R tau") |
| pubmed:28148553 | p(CONSO:"Tau isoform F (441 aa)") directlyIncreases p(CONSO:"4R tau") |
| pubmed:23407988 | p(CONSO:"Tau isoform F (441 aa)") isA p(CONSO:"4R tau") |
| pubmed:28148553 | p(CONSO:"Tau isoform F (441 aa)") causesNoChange p(HGNC:EIF2AK3) |
| pubmed:28148553 | p(CONSO:"Tau isoform F (441 aa)") causesNoChange p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | p(CONSO:"Tau isoform F (441 aa)") decreases p(HGNC:EIF2A) |
| pubmed:28148553 | p(CONSO:"Tau isoform F (441 aa)") increases p(CONSO:"Tau epitope, CP13") |
| pubmed:28148553 | p(CONSO:"Tau isoform F (441 aa)") increases p(CONSO:"Tau epitope, AD2") |
| pubmed:28148553 | p(CONSO:"Tau isoform F (441 aa)") increases a(CONSO:"Tau antibody, HT7") |
| pubmed:28148553 | p(CONSO:"Tau isoform F (441 aa)") causesNoChange a(CONSO:"Tau antibody, MC1") |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)") increases bp(GO:"microtubule bundle formation") |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)") increases composite(a(GO:"microtubule bundle"), p(CONSO:"Tau isoform F (441 aa)")) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)") directlyIncreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation", Lys, 40)) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)") increases bp(GO:"microtubule cytoskeleton organization") |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)") increases p(HGNC:AKT1) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)") increases act(p(HGNC:AKT1)) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)") increases act(p(HGNC:AKT1)) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)") increases p(HGNC:AKT1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)") decreases p(HGNC:GSK3B) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)") decreases p(HGNC:ATF6, frag("?")) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)") decreases bp(GO:"ATF6-mediated unfolded protein response") |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)") causesNoChange p(HGNC:ERN1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)") causesNoChange bp(GO:"IRE1-mediated unfolded protein response") |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)") causesNoChange p(HGNCGENEFAMILY:"CCAAT/enhancer binding proteins") |
| pubmed:27574109 | p(CONSO:"Tau isoform F (441 aa)") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pubmed:27574109 | p(CONSO:"Tau isoform F (441 aa)") increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | p(CONSO:"Tau isoform F (441 aa)") positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:29191965 | p(CONSO:"Tau isoform F (441 aa)") decreases bp(GO:"anterograde axonal transport of mitochondrion") |
| pubmed:29191965 | p(CONSO:"Tau isoform F (441 aa)") decreases bp(GO:"retrograde axonal transport of mitochondrion") |
| pubmed:29686391 | tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation p(CONSO:"Tau isoform F (441 aa)") |
| pubmed:29686391 | p(CONSO:"Tau isoform F (441 aa)") positiveCorrelation tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | p(CONSO:"Tau isoform F (441 aa)") increases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) negativeCorrelation a(CHEBI:heparin) |
| pubmed:29686391 | tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation a(CONSO:"6-O-sulfated heparin") |
| pubmed:25374103 | p(CONSO:"Tau isoform F (441 aa)") causesNoChange bp(GO:"cell death") |
| pubmed:25374103 | p(CONSO:"Tau isoform F (441 aa)") increases act(p(HGNC:CASP3)) |
| pubmed:25374103 | p(CONSO:"Tau isoform F (441 aa)") decreases bp(GO:"mitochondrion transport along microtubule") |
| pubmed:25374103 | p(CONSO:"Tau isoform F (441 aa)") decreases bp(GO:"mitochondrion transport along microtubule") |
| pubmed:17493042 | p(CONSO:"Tau isoform F (441 aa)") partOf a(MESH:Brain) |
| pubmed:30145931 | r(HGNC:MAPT, loc(MESH:Dendrites)) increases p(HGNC:MAPT, loc(MESH:Dendrites)) |
| pubmed:18986241 | act(p(HGNC:GAL)) association path(MESH:Cognition) |
| pubmed:18986241 | act(p(HGNC:GAL)) association bp(MESH:"Neuronal Plasticity") |
| pubmed:18986241 | act(p(HGNC:GAL)) increases bp(GO:innervation) |
| pubmed:18986241 | act(p(HGNC:GAL)) regulates act(a(MESH:"Cholinergic Neurons")) |
| pubmed:18986241 | act(p(HGNC:GAL)) decreases a(CHEBI:amyloid-beta) |
| pubmed:18986241 | act(p(HGNC:GAL)) increases r(HGNC:CHAT) |
| pubmed:18986241 | act(p(HGNC:GAL)) causesNoChange p(CONSO:"Tau MN423") |
| pubmed:18986241 | act(p(HGNC:GAL)) increases r(HGNC:PPP1CA) |
| pubmed:18986241 | act(p(HGNC:GAL)) increases r(HGNC:PPP1CC) |
| pubmed:18986241 | p(CONSO:"Tau C3") biomarkerFor act(a(MESH:"Cholinergic Neurons")) |
| pubmed:24027553 | p(CONSO:"Tau C3") increases bp(GO:"apoptotic process") |
| pubmed:24027553 | p(CONSO:"Tau C3") increases a(CONSO:"Tau aggregates") |
| pubmed:24027553 | p(CONSO:"Tau C3") increases a(CONSO:"Tau aggregates") |
| pubmed:24027553 | p(CONSO:"Tau C3") negativeCorrelation bp(GO:cognition) |
| pubmed:24027553 | p(CONSO:"Tau C3") association path(MESH:"Neurofibrillary Tangles") |
| pubmed:25374103 | p(CONSO:"Tau C3") causesNoChange bp(GO:"cell death") |
| pubmed:25374103 | p(CONSO:"Tau C3") increases act(p(HGNC:CASP3)) |
| pubmed:25374103 | p(CONSO:"Tau C3") decreases bp(GO:"mitochondrion transport along microtubule") |
| pubmed:25374103 | p(CONSO:"Tau C3") decreases bp(GO:"mitochondrion transport along microtubule") |
| pubmed:18986241 | p(RGD:Ngf) increases r(RGD:Gal) |
| pubmed:18986241 | p(RGD:Ngf) decreases path(MESH:"Cognitive Dysfunction") |
| pubmed:18986241 | bp(GO:"amyloid-beta metabolic process") association a(MESH:"Cholinesterase Inhibitors") |
| pubmed:29758300 | bp(GO:"amyloid-beta metabolic process") association a(CHEBI:sphingolipid) |
| pubmed:18986241 | path(MESH:Anorexia) association a(MESH:"Cholinesterase Inhibitors") |
| pubmed:18986241 | bp(GO:"sympathetic nervous system development") association p(HGNC:NGF) |
| pubmed:18986241 | path(MESH:Cachexia) association p(HGNC:NGF) |
| pubmed:14556719 | path(MESH:Cachexia) increases bp(GO:"protein catabolic process") |
| pubmed:18986241 | path(MESH:Hyperalgesia) association p(HGNC:NGF) |
| pubmed:18986241 | g(HGNC:NGF) directlyIncreases p(HGNC:NGF) |
| pubmed:18986241 | a(MESH:latrepirdine) decreases act(p(HGNC:BCHE)) |
| pubmed:18986241 | a(MESH:latrepirdine) decreases act(p(HGNC:ACHE)) |
| pubmed:18986241 | a(MESH:latrepirdine) decreases bp(GO:"NMDA selective glutamate receptor signaling pathway") |
| pubmed:18986241 | a(MESH:latrepirdine) decreases bp(GO:"regulation of mitochondrial membrane permeability") |
| pubmed:18986241 | a(MESH:latrepirdine) increases bp(MESH:Neuroprotection) |
| pubmed:11230871 | a(MESH:"Neurotransmitter Agents") association p(FPLX:CHRN) |
| pubmed:11230871 | path(MESH:"Tourette Syndrome") association p(FPLX:CHRN) |
| pubmed:28901280 | a(CHEBI:cytisine) increases p(MESH:"Receptors, Nicotinic") |
| pubmed:11230871 | complex(CONSO:"alpha-4-containing nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:11230871 | complex(CONSO:"alpha-7-containing nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:11230871 | complex(CONSO:"alpha-7-containing nAChR") negativeCorrelation path(MESH:Schizophrenia) |
| pubmed:11230871 | complex(CONSO:"alpha-7-containing nAChR") regulates act(a(CHEBI:amyloid-beta)) |
| pubmed:11230871 | a(PUBCHEM:5662) association bp(GO:"synaptic transmission, cholinergic") |
| pubmed:11230871 | a(PUBCHEM:132228) increases p(FPLX:CHRN) |
| pubmed:11230871 | a(CHEBI:Ondansetron) decreases p(FPLX:CHRN) |
| pubmed:11230871 | a(PUBCHEM:119380) increases path(MESH:"Verbal Learning") |
| pubmed:11230871 | a(PUBCHEM:119380) increases bp(GO:memory) |
| pubmed:28132910 | a(CONSO:B-973) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:28132910 | a(CONSO:B-973) negativeCorrelation act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:28132910 | a(CONSO:B-973) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:28132910 | a(CONSO:B-973) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:28132910 | a(CONSO:B-973) increases act(a(CHEBI:acetylcholine)) |
| pubmed:28132910 | a(CONSO:B-973) increases act(p(HGNC:CHRNA7)) |
| pubmed:28132910 | a(CONSO:B-973) increases complex(a(GO:membrane), a(PUBCHEM:16068384)) |
| pubmed:28132910 | a(CONSO:B-973) increases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384)) |
| pubmed:28132910 | a(CONSO:B-973) increases complex(a(PUBCHEM:16068384), p(MGI:Chrna7)) |
| pubmed:28132910 | a(PUBCHEM:5288811) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:28391535 | a(PUBCHEM:5288811) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:28391535 | a(PUBCHEM:5288811) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:28391535 | a(PUBCHEM:5288811) causesNoChange act(a(CHEBI:nicotine)) |
| pubmed:28391535 | a(PUBCHEM:5288811) causesNoChange act(a(CHEBI:nicotine)) |
| pubmed:17640819 | composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu")), p(MGI:Psen1, var("p.Met146Leu"))) increases a(CHEBI:amyloid-beta) |
| pubmed:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") decreases act(p(MGI:App, frag("25_35"))) |
| pubmed:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") decreases act(p(MGI:App, frag("25_35"))) |
| pubmed:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases bp(GO:learning) |
| pubmed:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases bp(GO:learning) |
| pubmed:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases path(MESH:"Spatial Memory") |
| pubmed:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases path(MESH:"Spatial Memory") |
| pubmed:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") causesNoChange r(MGI:Chrna7) |
| pubmed:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases p(MGI:Chrna7) |
| pubmed:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases p(MGI:Chrna7) |
| pubmed:19721446 | a(MESH:"Peripheral Nervous System") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:19721446 | a(MESH:"Central Nervous System") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pubmed:30988501 | act(a(MESH:"Central Nervous System")) association bp(GO:"cytokine secretion") |
| pubmed:19721446 | bp(GO:"regulation of cation channel activity") association a(CHEBI:acetylcholine) |
| pubmed:19721446 | p(HGNC:CHRNA7, frag("231_255")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) |
| pubmed:19721446 | p(HGNC:CHRNA7, frag("231_255")) association act(a(PUBCHEM:11964458)) |
| pubmed:19721446 | act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("231_255")) |
| pubmed:19721446 | act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("262_280")) |
| pubmed:19721446 | act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("470_490")) |
| pubmed:19721446 | p(HGNC:CHRNA7, frag("262_280")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) |
| pubmed:19721446 | p(HGNC:CHRNA7, frag("262_280")) association act(a(PUBCHEM:11964458)) |
| pubmed:19721446 | p(HGNC:CHRNA7, frag("470_490")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) |
| pubmed:19721446 | p(HGNC:CHRNA7, frag("470_490")) association act(a(PUBCHEM:11964458)) |
| pubmed:19721446 | act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("231_255")) |
| pubmed:19721446 | act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("262_280")) |
| pubmed:19721446 | act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("470_490")) |
| pubmed:19721446 | p(HGNC:CHRNA4, frag("331_600")) association p(HGNC:YWHAH) |
| pubmed:19721446 | p(HGNC:CHRNA4, frag("331_600")) association p(HGNC:VSNL1) |
| pubmed:19721446 | p(HGNC:YWHAH) association p(HGNC:CHRNA4, frag("331_600")) |
| pubmed:19721446 | p(HGNCGENEFAMILY:Tubulins) association p(HGNC:CHRNB2) |
| pubmed:19721446 | p(HGNCGENEFAMILY:"Clathrin subunits") association p(HGNC:CHRNB2) |
| pubmed:19721446 | a(MESH:"AR-R 17779") increases bp(GO:learning) |
| pubmed:19721446 | a(MESH:"AR-R 17779") increases bp(GO:memory) |
| pubmed:19721446 | a(MESH:"AR-R 17779") decreases act(a(CHEBI:scopolamine)) |
| pubmed:19721446 | a(DRUGBANK:Facinicline) increases bp(GO:cognition) |
| pubmed:19721446 | a(DRUGBANK:Facinicline) increases bp(GO:memory) |
| pubmed:19721446 | a(DRUGBANK:Facinicline) increases path(MESH:"Memory, Episodic") |
| pubmed:19721446 | a(MESH:"alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid") increases path(CONSO:neurotoxicity) |
| pubmed:19721446 | a(MESH:"Entorhinal Cortex") association bp(GO:memory) |
| pubmed:19721446 | path(MESH:"Attention Deficit Disorder with Hyperactivity") association a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole") |
| pubmed:19721446 | path(MESH:"Attention Deficit Disorder with Hyperactivity") association a(MESH:pozanicline) |
| pubmed:19721446 | a(MESH:pozanicline) association path(MESH:"Attention Deficit Disorder with Hyperactivity") |
| pubmed:19721446 | a(MESH:Dihydro-beta-Erythroidine) decreases act(a(CHEBI:nicotine)) |
| pubmed:28391535 | a(MESH:Dihydro-beta-Erythroidine) decreases act(a(CHEBI:nicotine)) |
| pubmed:28391535 | a(MESH:Dihydro-beta-Erythroidine) decreases act(a(CHEBI:nicotine)) |
| pubmed:19721446 | a(MESH:Dihydro-beta-Erythroidine) decreases act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:28901280 | a(MESH:Dihydro-beta-Erythroidine) increases p(MESH:"Receptors, Nicotinic") |
| pubmed:28391535 | a(MESH:Dihydro-beta-Erythroidine) increases complex(a(MESH:"nicotinic receptor alpha4beta2"), a(MESH:Dihydro-beta-Erythroidine)) |
| pubmed:28391535 | a(MESH:Dihydro-beta-Erythroidine) decreases act(a(MESH:"Receptors, Nicotinic")) |
| pubmed:28391535 | a(MESH:Dihydro-beta-Erythroidine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:28391535 | a(MESH:Dihydro-beta-Erythroidine) increases complex(a(MESH:Dihydro-beta-Erythroidine), p(HGNC:CHRNB2)) |
| pubmed:28391535 | a(MESH:Dihydro-beta-Erythroidine) decreases act(a(MESH:"nicotinic receptor alpha3beta2")) |
| pubmed:28391535 | a(MESH:Dihydro-beta-Erythroidine) decreases act(a(MESH:"nicotinic receptor alpha4beta2")) |
| pubmed:28391535 | a(MESH:Dihydro-beta-Erythroidine) decreases act(a(MESH:"nicotinic receptor alpha3beta4")) |
| pubmed:28391535 | a(MESH:Dihydro-beta-Erythroidine) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:19721446 | a(CHEBI:varenicline) increases path(MESH:"Smoking Cessation") |
| pubmed:28391535 | a(CHEBI:varenicline) association path(MESH:"Smoking Cessation") |
| pubmed:19721446 | a(CHEBI:varenicline) increases act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:19721446 | a(CHEBI:varenicline) increases act(p(HGNC:CHRNA7)) |
| pubmed:28391535 | a(CHEBI:varenicline) increases act(a(MESH:"nicotinic receptor alpha4beta2")) |
| pubmed:28391535 | a(CHEBI:varenicline) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pubmed:19721446 | complex(p(HGNC:CHRNA4), p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) association a(MESH:"Dopaminergic Neurons") |
| pubmed:19721446 | complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) association a(MESH:"Dopaminergic Neurons") |
| pubmed:19721446 | complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2)) association a(MESH:"Dopaminergic Neurons") |
| pubmed:19721446 | g(HGNC:CHRNA5) association path(MESH:"Lung Neoplasms") |
| pubmed:19721446 | g(HGNC:CHRNA3) association path(MESH:"Lung Neoplasms") |
| pubmed:19721446 | g(HGNC:CHRNB4) association path(MESH:"Lung Neoplasms") |
| pubmed:19721446 | a(CHEBI:sertraline) decreases a(CHEBI:monoamine) |
| pubmed:19721446 | a(CHEBI:sertraline) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19721446 | a(CHEBI:paroxetine) decreases a(CHEBI:monoamine) |
| pubmed:19721446 | a(CHEBI:paroxetine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19721446 | a(CHEBI:nefazodone) decreases a(CHEBI:monoamine) |
| pubmed:19721446 | a(CHEBI:nefazodone) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19721446 | a(CHEBI:nisoxetine) decreases a(CHEBI:monoamine) |
| pubmed:19721446 | a(CHEBI:nisoxetine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19721446 | a(CHEBI:nomifensine) decreases a(CHEBI:monoamine) |
| pubmed:19721446 | a(CHEBI:nomifensine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19721446 | a(CHEBI:vanoxerine) decreases a(CHEBI:monoamine) |
| pubmed:19721446 | a(CHEBI:vanoxerine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pubmed:19721446 | a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") increases act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:19721446 | a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") association path(MESH:Vomiting) |
| pubmed:19721446 | a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") association path(MESH:Nausea) |
| pubmed:19721446 | a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") increases act(complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4))) |
| pubmed:19721446 | a(MESH:"3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo(3.2.0)heptane") increases act(p(CONSO:"alpha-4 beta-2 nAChR")) |
| pubmed:19721446 | complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) association a(MESH:Conotoxins) |
| pubmed:19721446 | complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) increases act(a(MESH:Lymphocytes)) |
| pubmed:28901280 | complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) increases p(MESH:"Receptors, Nicotinic") |
| pubmed:28901280 | path(MESH:Pain) association p(MESH:"Receptors, Nicotinic") |
| pubmed:22040696 | p(FPLX:Cyclophilin) increases p(HGNC:CHRNA7) |
| pubmed:22040696 | p(HGNC:CANX) increases p(FPLX:CHRN) |
| pubmed:22040696 | composite(p(HGNC:HTR3A), p(HGNC:RIC3)) decreases tloc(p(HGNC:HTR3A), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) |
| pubmed:22040696 | p(UNIPROT:P34371) increases act(p(FPLX:CHRN)) |
| pubmed:22040696 | p(FPLX:CHRN, pmod(go:0006468 ! "protein phosphorylation", Tyr)) decreases act(p(FPLX:CHRN)) |
| pubmed:22040696 | complex(p(FPLX:CHRN), p(FPLX:SRC)) increases bp(GO:"catecholamine secretion") |
| pubmed:22040696 | complex(p(FPLX:CHRN), p(HGNC:FYN)) increases bp(GO:"catecholamine secretion") |
| pubmed:22040696 | complex(p(HGNC:CHRNA7), p(HGNC:FYN)) increases act(p(FPLX:PI3K)) |
| pubmed:22040696 | complex(p(HGNC:CHRNA7), p(HGNC:JAK2)) increases act(p(FPLX:PI3K)) |
| pubmed:21787755 | bp(GO:"maintenance of synapse structure") association p(CONSO:"alpha-7-containing nAChR") |
| pubmed:22040696 | act(a(MESH:"SNARE Proteins")) increases tloc(p(HGNC:CHRNA7), fromLoc(GO:"cell surface"), toLoc(GO:endosome)) |
| pubmed:22040696 | act(a(MESH:"SNARE Proteins")) causesNoChange tloc(p(HGNC:CHRNA7), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) |
| pubmed:22040696 | p(HGNC:CHRNA7, var("p.Leu335Ala")) decreases tloc(p(HGNC:CHRNA7), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) |
| pubmed:22040696 | p(HGNC:CHRNA7, var("p.Leu336Ala")) decreases tloc(p(HGNC:CHRNA7), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) |
| pubmed:22040696 | p(HGNC:CHRNA7, var("p.Leu343Ala")) decreases tloc(p(HGNC:CHRNA7), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) |
| pubmed:22040696 | r(HGNC:RIC3) positiveCorrelation path(MESH:Schizophrenia) |
| pubmed:22040696 | r(HGNC:RIC3) positiveCorrelation path(MESH:"Bipolar Disorder") |
| pubmed:22040696 | path(MESH:"Bipolar Disorder") positiveCorrelation r(HGNC:RIC3) |
| pubmed:22040696 | path(MESH:"Bipolar Disorder") negativeCorrelation act(p(HGNC:RIC3), ma(go:0044183 ! "protein binding involved in protein folding")) |
| pubmed:30740335 | path(MESH:"Bipolar Disorder") association p(DBSNP:rs2269577) |
| pubmed:22040696 | bp(GO:"response to ischemia") increases path(MESH:"Renal Insufficiency") |
| pubmed:18174175 | complex(a(CHEBI:epibatidine), p(CONSO:"alpha-3 beta-2 nAChR")) increases act(p(CONSO:"alpha-3 beta-2 nAChR")) |
| pubmed:26837465 | composite(p(GO:"neurofibrillary tangle"), p(HGNC:ESR1)) association composite(p(GO:"neurofibrillary tangle"), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) |
| pubmed:26837465 | composite(p(GO:"neurofibrillary tangle"), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) association composite(p(GO:"neurofibrillary tangle"), p(HGNC:ESR1)) |
| pubmed:21787755 | bp(GO:"neuron projection maintenance") association p(CONSO:"alpha-7-containing nAChR") |
| pubmed:21787755 | composite(a(CHEBI:nicotine), p(CONSO:"alpha-4-containing nAChR")) increases complex(a(CHEBI:nicotine), p(CONSO:"alpha-4-containing nAChR")) |
| pubmed:21787755 | composite(p(HGNC:CHRNA4), p(HGNC:CHRNB4)) increases p(CONSO:"alpha-4 beta-4 nAChR") |
| pubmed:21787755 | composite(a(CHEBI:nicotine), p(CONSO:"alpha-4 beta-4 nAChR")) increases complex(a(CHEBI:nicotine), p(CONSO:"alpha-4 beta-4 nAChR")) |
| pubmed:21787755 | composite(r(HGNC:CHRNA4), r(HGNC:CHRNB4)) association path(MESH:"Tobacco Use Disorder") |
| pubmed:21787755 | path(MESH:Pleasure) association p(CONSO:"alpha-6-containing nAChR") |
| pubmed:21787755 | a(MESH:"neuronal bungarotoxin") decreases act(p(CONSO:"alpha-3 beta-2 nAChR")) |
| pubmed:21787755 | a(MESH:"neuronal bungarotoxin") decreases act(p(CONSO:"alpha-6-containing nAChR")) |
| pubmed:21787755 | p(CONSO:kappa-Bungarotoxin) decreases act(p(CONSO:"alpha-3 beta-2 nAChR")) |
| pubmed:21787755 | p(CONSO:kappa-Bungarotoxin) decreases act(p(CONSO:"alpha-6-containing nAChR")) |
| pubmed:21787755 | a(MESH:"alpha-conotoxin PnIA") decreases act(p(CONSO:"alpha-3 beta-2 nAChR")) |
| pubmed:21787755 | a(MESH:"alpha-conotoxin PnIA") decreases act(p(CONSO:"alpha-6-containing nAChR")) |
| pubmed:21787755 | bp(MESH:"Drug Interactions") association r(HGNC:CHRNA6) |
| pubmed:21787755 | bp(MESH:"Drug Interactions") association p(HGNC:CHRNA6) |
| pubmed:28901280 | composite(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) |
| pubmed:28901280 | complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases act(a(MESH:"Peripheral Nervous System")) |
| pubmed:28901280 | complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(MESH:Sodium), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:28901280 | complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"calcium cation"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:28901280 | complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pubmed:28901280 | composite(a(MESH:Nicotine), p(MESH:"Receptors, Nicotinic")) increases complex(a(MESH:Nicotine), p(MESH:"Receptors, Nicotinic")) |
| pubmed:28901280 | a(MESH:Nicotine) increases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) |
| pubmed:28901280 | a(MESH:Nicotine) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| pubmed:28901280 | a(MESH:Nicotine) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) |
| pubmed:28901280 | a(MESH:Nicotine) decreases bp(GO:"neuron death") |
| pubmed:28901280 | a(MESH:Nicotine) increases p(MESH:"Receptors, Nicotinic") |
| pubmed:28901280 | a(MESH:Nicotine) increases bp(GO:"nodal receptor complex assembly") |
| pubmed:28901280 | a(MESH:Nicotine) increases act(p(MESH:"Proteasome Endopeptidase Complex")) |
| pubmed:28901280 | a(MESH:Nicotine) increases a(MESH:Glutamates) |
| pubmed:28901280 | a(MESH:Nicotine) increases a(MESH:Glutamates) |
| pubmed:28901280 | a(MESH:Nicotine) increases p(MESH:"Receptors, GABA") |
| pubmed:28901280 | a(MESH:Nicotine) decreases p(MESH:"Receptors, GABA") |
| pubmed:28901280 | a(MESH:Nicotine) increases bp(GO:"action potential initiation") |
| pubmed:28901280 | a(MESH:Nicotine) increases a(MESH:Dopamine, loc(MESH:"Nucleus Accumbens")) |
| pubmed:28901280 | a(MESH:Nicotine) increases a(MESH:Dopamine, loc(MESH:"Nucleus Accumbens")) |
| pubmed:28901280 | a(MESH:Nicotine) increases act(p(HGNC:CHRNA7)) |
| pubmed:28901280 | a(MESH:Nicotine) decreases act(p(HGNC:CHRNA7)) |
| pubmed:28901280 | a(MESH:Nicotine) increases act(p(MESH:"Receptors, N-Methyl-D-Aspartate")) |
| pubmed:28901280 | a(MESH:Nicotine) increases bp(MESH:"Long-Term Potentiation") |
| pubmed:28901280 | act(a(MESH:Nicotine)) association g(DBSNP:rs16969968) |
| pubmed:28901280 | a(MESH:Nicotine) increases p(MGI:Chrna5) |
| pubmed:28901280 | a(MESH:Nicotine) increases p(MGI:Chrna2) |
| pubmed:28901280 | a(MESH:Nicotine) increases path(MESH:Neoplasms) |
| pubmed:28901280 | a(MESH:Nicotine) causesNoChange act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) |
| pubmed:28901280 | a(MESH:Nicotine) causesNoChange act(p(HGNC:CHRNA9)) |
| pubmed:28901280 | complex(a(MESH:Nicotine), p(MESH:"Receptors, Nicotinic"), loc(MESH:Brain)) decreases path(MESH:Anxiety) |
| pubmed:28901280 | complex(a(MESH:"Receptors, Muscarinic"), a(MESH:Acetylcholine)) increases act(a(MESH:"Central Nervous System")) |
| pubmed:28901280 | bp(GO:"cell-cell signaling") association a(MESH:Acetylcholine) |
| pubmed:19933700 | bp(GO:"cell-cell signaling") association p(HGNC:PPP2R1A) |
| pubmed:26751493 | bp(GO:"cell-cell signaling") association complex(p(CONSO:"projection domain"), p(HGNC:LCK)) |
| pubmed:26751493 | bp(GO:"cell-cell signaling") association complex(p(CONSO:"projection domain"), p(HGNC:FGR)) |
| pubmed:26751493 | bp(GO:"cell-cell signaling") association complex(p(CONSO:"projection domain"), p(HGNC:SRC)) |
| pubmed:26751493 | bp(GO:"cell-cell signaling") association complex(p(CONSO:"projection domain"), p(HGNC:GRB2)) |
| pubmed:26751493 | bp(GO:"cell-cell signaling") association complex(p(CONSO:"projection domain"), p(FPLX:PLC)) |
| pubmed:26751493 | bp(GO:"cell-cell signaling") association complex(a(CHEBI:phosphatidylinositol), p(CONSO:"projection domain")) |
| pubmed:26751493 | bp(GO:"cell-cell signaling") association complex(a(CHEBI:"phosphatidylinositol bisphosphate"), p(CONSO:"projection domain")) |
| pubmed:26751493 | bp(GO:"cell-cell signaling") association complex(p(CONSO:"projection domain"), p(HGNC:PIN1)) |
| pubmed:28901280 | bp(GO:"cell proliferation") association a(MESH:Acetylcholine) |
| pubmed:28901280 | bp(GO:"cell proliferation") association p(MESH:"Receptors, Nicotinic") |
| pubmed:28901280 | bp(GO:"secretion by cell") association a(MESH:Acetylcholine) |
| pubmed:28901280 | bp(MESH:"Autocrine Communication") association a(MESH:Acetylcholine) |
| pubmed:28901280 | bp(MESH:"Paracrine Communication") association a(MESH:Acetylcholine) |
| pubmed:28901280 | a(MESH:Erythrocytes) increases a(MESH:Acetylcholine) |
| pubmed:28901280 | a(MESH:Erythrocytes) increases a(MESH:"Choline O-Acetyltransferase") |
| pubmed:29626319 | a(MESH:Erythrocytes) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | a(MESH:Erythrocytes) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:28901280 | a(MESH:"Epithelial Cells") increases a(MESH:Acetylcholine) |
| pubmed:28901280 | a(MESH:"Epithelial Cells") increases a(MESH:"Choline O-Acetyltransferase") |
| pubmed:28901280 | a(MESH:Placenta) increases a(MESH:Acetylcholine) |
| pubmed:28901280 | a(MESH:Placenta) increases a(MESH:"Choline O-Acetyltransferase") |
| pubmed:28901280 | path(MESH:Learning) association p(MESH:"Receptors, Nicotinic") |
| pubmed:28901280 | path(MESH:"Motor Activity") association p(MESH:"Receptors, Nicotinic") |
| pubmed:28391535 | path(MESH:"Motor Activity") negativeCorrelation a(CHEBI:nicotine) |
| pubmed:28901280 | bp(MESH:Analgesia) association p(MESH:"Receptors, Nicotinic") |
| pubmed:28901280 | composite(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) increases complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) |
| pubmed:28901280 | composite(p(HGNC:CHRNA7), p(HGNC:CHRNB3)) increases complex(p(HGNC:CHRNA7), p(HGNC:CHRNB3)) |
| pubmed:28901280 | composite(p(HGNC:CHRNA7), p(HGNC:CHRNB4)) increases complex(p(HGNC:CHRNA7), p(HGNC:CHRNB4)) |
| pubmed:28901280 | composite(p(HGNC:CHRNA5), p(HGNC:CHRNA7)) increases complex(p(HGNC:CHRNA5), p(HGNC:CHRNA7)) |
| pubmed:28901280 | r(HGNC:CHRFAM7A) association a(MESH:Lymphocytes) |
| pubmed:28901280 | a(MESH:Carbachol) increases p(MESH:"Receptors, Nicotinic") |
| pubmed:28901280 | a(MESH:Varenicline) increases p(MESH:"Receptors, Nicotinic") |
| pubmed:28901280 | a(MESH:Mecamylamine) increases p(MESH:"Receptors, Nicotinic") |
| pubmed:28901280 | a(MESH:Glutamates) increases bp(MESH:"Long-Term Potentiation") |
| pubmed:28901280 | a(MESH:Glutamates) increases bp(GO:"action potential initiation") |
| pubmed:28901280 | bp(UBERON:0002138) positiveCorrelation p(MESH:"Receptors, Nicotinic") |
| pubmed:28901280 | bp(UBERON:0002138) positiveCorrelation p(HGNC:CHRNA3) |
| pubmed:28901280 | bp(UBERON:0002138) positiveCorrelation p(HGNC:CHRNB4) |
| pubmed:28901280 | bp(UBERON:0002138) positiveCorrelation p(HGNC:CHRNA5) |
| pubmed:28901280 | p(MGI:Chrna5) regulates act(a(MESH:Nicotine)) |
| pubmed:28901280 | p(MGI:Chrnb4) decreases act(a(MESH:Nicotine)) |
| pubmed:28901280 | p(INTERPRO:"Ly6/PLAUR domain-containing protein 6-like") regulates p(MESH:"Receptors, Nicotinic") |
| pubmed:28901280 | composite(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2)) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2)) |
| pubmed:28901280 | composite(p(HGNC:CHRNA3), p(HGNC:CHRNA5), p(HGNC:CHRNB4)) increases complex(p(HGNC:CHRNA3), p(HGNC:CHRNA5), p(HGNC:CHRNB4)) |
| pubmed:28901280 | g(DBSNP:rs1051730) association path(MESH:"Lung Neoplasms") |
| pubmed:28901280 | g(DBSNP:rs1051730) association path(MESH:"Tobacco Use Disorder") |
| pubmed:28901280 | bp(GO:"JAK-STAT cascade") increases a(CHEBI:"calcium cation", loc(GO:intracellular)) |
| pubmed:28901280 | a(MESH:Epithelium) regulates a(MESH:Acetylcholine) |
| pubmed:28901280 | act(a(MESH:Epithelium)) association p(MGI:Chrna7) |
| pubmed:28901280 | a(MESH:Choline) increases act(p(HGNC:CHRNA9)) |
| pubmed:28901280 | a(MESH:Phosphorylcholine) causesNoChange complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) |
| pubmed:28901280 | a(MESH:Phosphorylcholine) causesNoChange p(HGNC:CHRNA9) |
| pubmed:28901280 | a(MESH:"Ganglia, Spinal") increases complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) |
| pubmed:28901280 | a(MESH:"Ganglia, Spinal") increases p(HGNC:CHRNA9) |
| pubmed:28901280 | path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA9) |
| pubmed:28901280 | path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA9) |
| pubmed:28901280 | path(MESH:"Breast Neoplasms") increases complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) |
| pubmed:28901280 | path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA5) |
| pubmed:28901280 | path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA10) |
| pubmed:23516100 | p(MESH:Proteins, frag("?")) increases p(MESH:Proteins) |
| pubmed:23516100 | p(MESH:Proteins, frag("?")) negativeCorrelation act(complex(GO:organelle)) |
| pubmed:23516100 | p(MESH:Proteins, frag("?")) association path(MESH:"Oxidative Stress") |
| pubmed:23516100 | p(MESH:Proteins, frag("?")) association bp(GO:"cell death") |
| pubmed:23516100 | act(complex(GO:organelle)) negativeCorrelation p(MESH:Proteins, frag("?")) |
| pubmed:23516100 | p(HGNC:MAPT, frag("?")) positiveCorrelation path(DOID:"neurodegenerative disease") |
| pubmed:23516100 | p(HGNC:MAPT, frag("?")) positiveCorrelation path(DOID:tauopathy) |
| pubmed:23516100 | p(HGNC:MAPT, frag("?")) increases path(MESH:Virulence) |
| pubmed:23516100 | p(HGNC:MAPT, frag("?")) positiveCorrelation path(DOID:"Alzheimer's disease") |
| pubmed:23516100 | p(HGNC:MAPT, frag("?")) increases p(GO:"neurofibrillary tangle") |
| pubmed:23516100 | p(HGNC:MAPT, frag("?")) decreases act(p(MESH:Caspases)) |
| pubmed:23516100 | p(HGNC:MAPT, frag("?")) increases complex(MESH:"Neurofibrillary Tangles") |
| pubmed:23516100 | p(HGNC:MAPT, frag("?")) increases path(MESH:"Plaque, Amyloid") |
| pubmed:23516100 | p(HGNC:MAPT, frag("?")) increases p(CONSO:"Tau aggregates") |
| pubmed:29758300 | p(HGNC:MAPT, frag("?")) increases path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | p(HGNC:MAPT, frag("?")) association complex(GO:"proteasome complex") |
| pubmed:29758300 | p(HGNC:MAPT, frag("?")) association bp(GO:autophagy) |
| pubmed:30116051 | p(HGNC:MAPT, frag("?")) decreases bp(GO:"chaperone-mediated autophagy") |
| pubmed:26631930 | p(HGNC:MAPT, frag("?")) increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, frag("?")) increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, frag("?")) increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, frag("?")) increases path(CONSO:Neurodegeneration) |
| pubmed:29626319 | p(HGNC:MAPT, frag("?")) increases path(CONSO:neurotoxicity) |
| pubmed:23516100 | a(CONSO:MN423) increases complex(a(CONSO:MN423), p(HGNC:MAPT, frag("1_391"))) |
| pubmed:4255369 | a(CONSO:MN423) increases a(CONSO:"Tau oligomers") |
| pubmed:23516100 | p(HGNC:MAPT, frag("1_391")) increases p(CONSO:"Tau fibrils") |
| pubmed:23516100 | p(HGNC:MAPT, frag("1_391")) increases p(CONSO:"Tau aggregates") |
| pubmed:23516100 | p(HGNC:MAPT, frag("1_421")) positiveCorrelation path(DOID:"neurodegenerative disease") |
| pubmed:23516100 | p(HGNC:MAPT, frag("1_421")) negativeCorrelation bp(GO:cognition) |
| pubmed:28420982 | p(HGNC:MAPT, frag("1_421")) decreases bp(GO:"mitochondrion organization") |
| pubmed:26631930 | p(HGNC:MAPT, frag("1_421")) increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, frag("1_421")) increases a(GO:"neurofibrillary tangle") |
| pubmed:23516100 | p(HGNC:MAPT, frag("?"), pmod(go:0006468 ! "protein phosphorylation")) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) |
| pubmed:23516100 | p(HGNC:MAPT, frag("?"), pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation bp(GO:"anterograde axonal transport") |
| pubmed:23516100 | p(HGNC:MAPT, frag("?"), pmod(go:0006468 ! "protein phosphorylation")) increases bp(GO:"cell death") |
| pubmed:23516100 | p(HGNC:ATXN3, frag("1_?")) increases path(MESH:Virulence) |
| pubmed:23516100 | p(HGNC:ATXN3, frag("1_?")) positiveCorrelation bp(GO:"neuron death") |
| pubmed:14556719 | p(HGNC:ATXN3) increases complex(p(HGNC:ATXN3), p(HGNC:RAD23A)) |
| pubmed:23516100 | p(HGNC:APP, frag("1_?")) decreases act(a(CHEBI:"cytochrome c")) |
| pubmed:23516100 | p(HGNC:APP, frag("1_?")) increases a(CHEBI:"hydrogen peroxide") |
| pubmed:23516100 | p(HGNC:APP, frag("1_?")) positiveCorrelation path(CONSO:"mitochondrial dysfunction") |
| pubmed:23516100 | p(HGNC:APP, frag("1_?")) increases path(MESH:"Neurotoxicity Syndromes") |
| pubmed:23516100 | p(HGNC:APP, frag("1_?")) decreases p(HGNC:APP, frag("?_*")) |
| pubmed:23516100 | p(HGNC:APP, frag("1_?")) decreases act(p(MESH:"Molecular Motor Proteins")) |
| pubmed:23516100 | p(HGNC:APP, frag("1_?")) decreases act(p(MESH:"Transcription Factors")) |
| pubmed:23516100 | p(HGNC:SNCA, frag("1_119")) decreases a(CHEBI:dopamine) |
| pubmed:23516100 | p(HGNC:SNCA, frag("1_119")) causesNoChange a(MESH:"Dopaminergic Neurons") |
| pubmed:23516100 | p(HGNC:SNCA, frag("1_120")) decreases a(CHEBI:dopamine) |
| pubmed:23516100 | p(HGNC:SNCA, frag("1_120")) increases path(MESH:"Oxidative Stress") |
| pubmed:23516100 | p(HGNC:SNCA, frag("1_120")) increases p(CONSO:"alpha-synuclein aggregates") |
| pubmed:23516100 | p(HGNC:SNCA, frag("1_?")) increases p(CONSO:"alpha-synuclein fibrils") |
| pubmed:23516100 | p(HGNC:SNCA, frag("1_?")) increases p(CONSO:"alpha-synuclein aggregates") |
| pubmed:23516100 | p(HGNC:SNCA, frag("1_?")) increases p(CONSO:"alpha-synuclein aggregates") |
| pubmed:12714745 | p(CONSO:"alpha-synuclein fibrils") positiveCorrelation g(DBSNP:rs104893877) |
| pubmed:23516100 | p(HGNC:HTT, frag("?"), loc(GO:nucleus)) increases bp(GO:"cell death") |
| pubmed:23516100 | p(HGNC:HTT, frag("?")) increases bp(GO:"cell death") |
| pubmed:23516100 | p(HGNC:HTT, frag("?")) increases tloc(p(HGNC:HTT, frag("?")), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:23516100 | p(HGNC:HTT, frag("?")) positiveCorrelation path(DOID:"Huntington's disease") |
| pubmed:23516100 | p(HGNC:HTT, frag("?")) increases path(MESH:"Neurotoxicity Syndromes") |
| pubmed:23516100 | path(DOID:"Lewy body dementia") increases p(HGNC:SNCA, frag("10_122")) |
| pubmed:23516100 | act(p(HGNC:CASP7)) increases complex(p(HGNC:CASP7), p(HGNC:MAPT, frag("1_421"))) |
| pubmed:23516100 | p(HGNC:CASP7) increases p(HGNC:MAPT, frag("?")) |
| pubmed:23516100 | p(HGNC:CASP7) increases p(HGNC:MAPT, frag("421_*"), var("?")) |
| pubmed:23516100 | act(p(HGNC:CASP7)) increases p(HGNC:ATXN7, frag("?")) |
| pubmed:23516100 | tloc(p(HGNC:CASP7), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) increases act(p(HGNC:CASP7, loc(GO:nucleus))) |
| pubmed:23516100 | act(p(HGNC:CASP7)) increases p(HGNC:TARDBP, frag("?")) |
| pubmed:23516100 | act(p(HGNC:CASP6)) increases p(HGNC:HTT, frag("1_586")) |
| pubmed:23516100 | p(HGNC:CASP6) increases p(HGNC:HTT, frag("1_586")) |
| pubmed:23516100 | p(HGNC:CASP6) increases p(HGNC:MAPT, frag("1_13")) |
| pubmed:23516100 | p(HGNC:CASP6) increases p(HGNC:MAPT, frag("1_402")) |
| pubmed:23516100 | p(HGNC:CASP6) increases p(HGNC:MAPT, frag("?")) |
| pubmed:24027553 | act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("?_*")) |
| pubmed:24027553 | act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("?_*")) |
| pubmed:24027553 | act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("1_?")) |
| pubmed:24027553 | act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("1_?")) |
| pubmed:24027553 | act(p(HGNC:CASP6)) increases bp(GO:"apoptotic process") |
| pubmed:24027553 | act(p(HGNC:CASP6)) increases p(HGNC:MAPT, var("p.Asp421*")) |
| pubmed:24027553 | act(p(HGNC:CASP6)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23516100 | p(HGNC:HTT, frag("1_586")) increases tloc(p(HGNC:HTT, frag("1_586")), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:23516100 | tloc(p(HGNC:HTT, frag("1_586")), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) increases a(MESH:"Toxic Actions") |
| pubmed:23516100 | path(MESH:"TDP-43 Proteinopathies") increases tloc(p(HGNC:TARDBP), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) |
| pubmed:30837838 | path(MESH:"TDP-43 Proteinopathies") increases tloc(p(HGNC:TARDBP), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) |
| pubmed:18305152 | path(MESH:"TDP-43 Proteinopathies") association p(CONSO:"TDP-43 aggregates", loc(GO:cytoplasm)) |
| pubmed:18305152 | path(MESH:"TDP-43 Proteinopathies") isA path(DOID:"frontotemporal dementia") |
| pubmed:28669544 | path(MESH:"TDP-43 Proteinopathies") increases path(EFO:"neurodegenerative disease") |
| pubmed:28669544 | path(MESH:"TDP-43 Proteinopathies") increases deg(p(HGNC:APP)) |
| pubmed:28669544 | path(MESH:"TDP-43 Proteinopathies") decreases path(DOID:"Alzheimer's disease") |
| pubmed:28669544 | path(MESH:"TDP-43 Proteinopathies") directlyIncreases p(HGNC:CD68) |
| pubmed:30837838 | path(MESH:"TDP-43 Proteinopathies") decreases p(HGNC:TARDBP, pmod(CONSO:hyperphosphorylation), loc(GO:"inclusion body")) |
| pubmed:30837838 | path(MESH:"TDP-43 Proteinopathies") decreases p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) |
| pubmed:30837838 | path(MESH:"TDP-43 Proteinopathies") decreases complex(CONSO:"TDP-43 aggregates") |
| pubmed:30837838 | path(MESH:"TDP-43 Proteinopathies") decreases p(HGNC:TARDBP, frag("274_414")) |
| pubmed:23516100 | p(HGNC:TARDBP, frag("?_*")) increases tloc(p(HGNC:TARDBP), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) |
| pubmed:23516100 | p(HGNC:TARDBP, frag("?_*")) increases p(CONSO:"TDP-43 aggregates") |
| pubmed:18305152 | p(CONSO:"TDP-43 aggregates", loc(GO:cytoplasm)) association path(DOID:"frontotemporal dementia") |
| pubmed:18305152 | p(CONSO:"TDP-43 aggregates", loc(GO:cytoplasm)) association path(MESH:"TDP-43 Proteinopathies") |
| pubmed:23384725 | p(CONSO:"TDP-43 aggregates") association p(HGNC:TARDBP, frag("101_191"), pmod(GO:"protein oxidation", Cys, 173)) |
| pubmed:23384725 | p(CONSO:"TDP-43 aggregates") association p(HGNC:TARDBP, frag("101_191"), pmod(GO:"protein oxidation", Cys, 175)) |
| pubmed:30837838 | p(CONSO:"TDP-43 aggregates", loc(GO:"inclusion body")) decreases act(p(HGNC:TARDBP)) |
| pubmed:30837838 | p(CONSO:"TDP-43 aggregates") increases p(HGNC:TARDBP, loc(GO:"inclusion body")) |
| pubmed:30837838 | p(CONSO:"TDP-43 aggregates", loc(GO:"inclusion body")) increases a(MESH:"Toxic Actions") |
| pubmed:30837838 | act(p(CONSO:"TDP-43 aggregates"), ma(GO:"protease binding")) increases p(HGNC:TARDBP, frag("104_*")) |
| pubmed:30837838 | p(CONSO:"TDP-43 aggregates") decreases p(CONSO:"amyloid-beta aggregates") |
| pubmed:23516100 | p(MESH:"Peptide Hydrolases") increases p(HGNC:MAPT, frag("128_*")) |
| pubmed:23516100 | p(MESH:"Peptide Hydrolases") increases p(HGNC:TARDBP, frag("208_*")) |
| pubmed:23516100 | p(MESH:"Peptide Hydrolases") increases p(HGNC:TARDBP, frag("1_219")) |
| pubmed:23516100 | p(MESH:"Peptide Hydrolases") increases p(HGNC:TARDBP, frag("1_247")) |
| pubmed:23516100 | p(HGNC:MAPT, pmod(CONSO:deamidation)) increases p(HGNC:MAPT, frag("1_255")) |
| pubmed:23516100 | p(HGNC:MAPT, pmod(CONSO:deamidation)) increases p(HGNC:MAPT, frag("266_*")) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:deamidation)) association a(CONSO:"paired helical filaments") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:deamidation)) increases a(CONSO:"Tau aggregates") |
| pubmed:30106381 | bp(GO:"nervous system development") association p(HGNC:ADNP) |
| pubmed:23516100 | bp(CONSO:"Glutamate excitotoxicity") negativeCorrelation bp(GO:"calcium ion homeostasis") |
| pubmed:23516100 | bp(CONSO:"Glutamate excitotoxicity") decreases act(p(HGNCGENEFAMILY:Calpains)) |
| pubmed:23516100 | act(p(HGNC:CAPN1)) increases complex(p(GO:"neurofibrillary tangle"), p(HGNC:CAPN1)) |
| pubmed:23516100 | act(p(HGNC:CAPN1)) increases complex(p(HGNC:CAPN1), p(MESH:"Neuropil Threads")) |
| pubmed:23516100 | p(HGNC:CAPN1) increases p(HGNC:SNCA, frag("?"), var("p.Ala53Thr")) |
| pubmed:23516100 | p(HGNC:CAPN1) increases p(HGNC:SNCA, frag("?"), var("p.Ala30Pro")) |
| pubmed:23516100 | p(HGNC:CAPN1) increases p(CONSO:"alpha-synuclein aggregates", frag("?")) |
| pubmed:30116051 | p(HGNC:CAPN1) decreases bp(GO:autophagy) |
| pubmed:30116051 | p(HGNC:CAPN1) decreases deg(p(HGNC:HTT, var("?"))) |
| pubmed:30837838 | p(HGNC:CAPN1) increases p(HGNC:TARDBP, frag("?"), var("p.Ala315Thr")) |
| pubmed:30837838 | p(HGNC:CAPN1) increases p(HGNC:TARDBP, frag("?"), var("p.Met337Val")) |
| pubmed:23516100 | act(p(HGNC:CAPN2)) increases complex(p(GO:"neurofibrillary tangle"), p(HGNC:CAPN2)) |
| pubmed:23516100 | act(p(HGNC:CAPN2)) increases complex(p(HGNC:CAPN2), p(MESH:"Neuropil Threads")) |
| pubmed:30116051 | p(HGNC:CAPN2) decreases bp(GO:autophagy) |
| pubmed:30116051 | p(HGNC:CAPN2) decreases deg(p(HGNC:HTT, var("?"))) |
| pubmed:24027553 | p(HGNC:CAPN2) association path(MESH:"Neurofibrillary Tangles") |
| pubmed:23516100 | p(HGNC:MAPT, frag("1_?")) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) |
| pubmed:24027553 | p(HGNC:MAPT, frag("1_?")) association path(MESH:"Neurofibrillary Tangles") |
| pubmed:23516100 | a(CONSO:Alz50) increases composite(a(CONSO:Alz50), p(HGNC:MAPT, frag("83_120"))) |
| pubmed:23516100 | p(MESH:"Serine Proteases") increases a(CHEBI:"amyloid-beta polypeptide 40") |
| pubmed:23516100 | p(HGNC:SNCA, frag("?")) increases p(CONSO:"alpha-synuclein aggregates") |
| pubmed:30985105 | p(HGNC:SNCA, frag("?")) increases a(CONSO:"alpha-synuclein aggregates") |
| pubmed:23516100 | p(HGNC:HTT, frag("?_*")) increases bp(GO:"neuron death") |
| pubmed:23516100 | path(DOID:"Machado-Joseph disease") increases p(HGNC:ATXN3, frag("?"), loc(GO:"nuclear inclusion body")) |
| pubmed:23516100 | path(DOID:"Machado-Joseph disease") association p(HGNC:ATXN3, frag("190_*")) |
| pubmed:14556719 | p(HGNC:ATXN3, frag("?")) decreases act(complex(GO:"proteasome complex")) |
| pubmed:14556719 | p(HGNC:ATXN3, frag("?")) increases act(p(HGNC:CASP12)) |
| pubmed:23516100 | p(HGNC:ATXN3, frag("1_260")) increases p(CONSO:"protein aggregates") |
| pubmed:23516100 | p(HGNC:ATXN3, frag("214_*")) increases path(DOID:"neurodegenerative disease") |
| pubmed:23516100 | p(HGNC:ATXN3, frag("190_*")) association path(DOID:"Machado-Joseph disease") |
| pubmed:24027553 | p(HGNC:MAPT, frag("?_*")) association path(MESH:"Neurofibrillary Tangles") |
| pubmed:18305152 | act(p(MESH:"Transcription Factors")) increases bp(GO:"cell division") |
| pubmed:18305152 | act(p(MESH:"Transcription Factors")) increases bp(GO:"cell cycle G1/S phase transition") |
| pubmed:23516100 | p(HGNC:ATXN7, frag("?")) positiveCorrelation path(DOID:"spinocerebellar ataxia type 7") |
| pubmed:23516100 | complex(p(HGNC:ATXN7), p(HGNC:CASP7)) increases tloc(p(HGNC:CASP7), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:23516100 | path(DOID:"spinocerebellar ataxia type 7") positiveCorrelation p(HGNC:ATXN7, frag("?")) |
| pubmed:23516100 | a(GO:lysosome) negativeCorrelation path(DOID:"Alzheimer's disease") |
| pubmed:23516100 | a(GO:lysosome) decreases p(HGNC:CTSD) |
| pubmed:18930136 | a(GO:lysosome) negativeCorrelation p(HGNC:CTSD) |
| pubmed:29758300 | a(GO:lysosome) increases bp(GO:"lysosomal protein catabolic process") |
| pubmed:22908190 | a(GO:lysosome) increases deg(p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"))) |
| pubmed:22908190 | a(GO:lysosome) increases deg(p(HGNC:MAPT)) |
| pubmed:22908190 | a(GO:lysosome) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | act(a(GO:lysosome)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | a(GO:lysosome) increases a(GO:organelle) |
| pubmed:18930136 | act(a(GO:lysosome)) decreases path(CONSO:Neurodegeneration) |
| pubmed:18930136 | act(a(GO:lysosome)) increases a(GO:autophagosome) |
| pubmed:18930136 | act(a(GO:lysosome)) increases a(GO:lysosome) |
| pubmed:18930136 | act(a(GO:lysosome)) negativeCorrelation path(MESH:"Neuronal Ceroid-Lipofuscinoses") |
| pubmed:29024336 | a(GO:lysosome) increases deg(p(CONSO:CONSO00053)) |
| pubmed:29590627 | a(GO:lysosome) association p(HGNC:MAPT, var("p.Pro301Ser")) |
| pubmed:29590627 | a(GO:lysosome) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:29590627 | a(GO:lysosome) association a(CONSO:"Tau aggregates") |
| pubmed:29590627 | a(GO:lysosome) increases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:23229893 | a(GO:lysosome) association p(HGNC:SUMO1) |
| pubmed:26702100 | a(GO:lysosome) association p(HGNC:LAMP1) |
| pubmed:26702100 | a(GO:lysosome) association p(HGNC:LAMP1) |
| pubmed:26702100 | a(GO:lysosome) association p(HGNC:CD63) |
| pubmed:26702100 | a(GO:lysosome) association p(HGNCGENEFAMILY:Cathepsins) |
| pubmed:26702100 | a(GO:lysosome) association a(MESH:"Vacuolar Proton-Translocating ATPases") |
| pubmed:24561250 | a(GO:lysosome) decreases act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:23516100 | p(HGNC:APP, var("p.Lys595Asn")) increases act(p(HGNC:CTSD)) |
| pubmed:23516100 | p(HGNC:APP, var("p.Lys595Asn")) increases p(HGNC:APP, frag("?")) |
| pubmed:23516100 | p(HGNC:APP, var("p.Met596Leu")) increases act(p(HGNC:CTSD)) |
| pubmed:23516100 | p(HGNC:APP, var("p.Met596Leu")) increases p(HGNC:APP, frag("?")) |
| pubmed:23516100 | a(PUBCHEM:10476) increases p(HGNC:MAPT, frag("?")) |
| pubmed:23516100 | p(MESH:Proteins, pmod(CONSO:deamidation)) increases p(CONSO:"amyloid-beta fibrils") |
| pubmed:23516100 | p(HGNC:TARDBP, pmod(CONSO:deamidation)) negativeCorrelation act(p(HGNC:TARDBP)) |
| pubmed:4255369 | p(CONSO:DC8E8) decreases p(HGNC:MAPT, frag("?"), pmod(CONSO:"Tau oligomers")) |
| pubmed:4255369 | p(CONSO:DC8E8) decreases a(CONSO:"Tau oligomers") |
| pubmed:4255369 | p(CONSO:DC8E8) directlyDecreases a(CONSO:"Tau oligomers") |
| pubmed:4255369 | p(CONSO:DC8E8) decreases complex(a(HGNC:MAPT), a(HGNC:MAPT)) |
| pubmed:4255369 | p(CONSO:DC8E8) decreases complex(a(HGNC:MAPT), a(HGNC:MAPT), a(HGNC:MAPT)) |
| pubmed:4255369 | p(CONSO:DC8E8) decreases p(CONSO:"4R tau", pmod(CONSO:"Tau oligomers"), var("p.151_391del")) |
| pubmed:4255369 | p(CONSO:DC8E8) decreases a(CONSO:"Tau fibrils") |
| pubmed:4255369 | p(CONSO:DC8E8) causesNoChange p(HGNC:MAPT) |
| pubmed:4255369 | p(CONSO:DC8E8) directlyIncreases complex(p(CONSO:"4R tau", var("p.151_391del")), p(CONSO:DC8E8)) |
| pubmed:4255369 | p(CONSO:DC8E8) directlyIncreases complex(p(CONSO:"4R tau", var("p.297_391del")), p(CONSO:DC8E8)) |
| pubmed:4255369 | p(CONSO:DC8E8) directlyIncreases complex(p(CONSO:"4R tau", var("p.1_357del")), p(CONSO:DC8E8)) |
| pubmed:4255369 | p(CONSO:DC8E8) directlyIncreases complex(p(CONSO:"4R tau", var("p.221_441del")), p(CONSO:DC8E8)) |
| pubmed:4255369 | p(CONSO:DC8E8) increases complex(p(CONSO:"Tau isoform F (441 aa)"), p(CONSO:DC8E8)) |
| pubmed:4255369 | p(CONSO:DC8E8) increases complex(p(CONSO:"Tau isoform C (410 aa)"), p(CONSO:DC8E8)) |
| pubmed:4255369 | p(CONSO:DC8E8) decreases complex(p(CONSO:"Tau isoform F (441 aa)", var("p.222_427del")), p(CONSO:DC8E8)) |
| pubmed:4255369 | p(CONSO:DC8E8) decreases complex(p(CONSO:"Tau isoform F (441 aa)", var("p.257_400del")), p(CONSO:DC8E8)) |
| pubmed:4255369 | a(CONSO:"Tau oligomers") increases a(CONSO:"Tau fibrils") |
| pubmed:4255369 | a(CONSO:"Tau oligomers") positiveCorrelation bp(GO:aging) |
| pubmed:4255369 | a(CONSO:"Tau oligomers") increases path(MESH:"Motor Disorders") |
| pubmed:27574109 | a(CONSO:"Tau oligomers") association a(CONSO:pretangles) |
| pubmed:27574109 | a(CONSO:"Tau oligomers") association a(CONSO:"Braak_Stage I") |
| pubmed:27574109 | a(CONSO:"Tau oligomers") association a(CONSO:"Braak_Stage II") |
| pubmed:27574109 | a(CONSO:"Tau oligomers") association a(MESH:"Neurofibrillary Tangles") |
| pubmed:27574109 | a(CONSO:"Tau oligomers") association path(CONSO:"Corticobasal Degeneration") |
| pubmed:27574109 | a(CONSO:"Tau oligomers") positiveCorrelation path(CONSO:"Corticobasal Degeneration") |
| pubmed:27574109 | a(CONSO:"Tau oligomers") positiveCorrelation path(CONSO:"Corticobasal Degeneration") |
| pubmed:27574109 | a(CONSO:"Tau oligomers") association a(GO:"Pick body") |
| pubmed:27574109 | a(CONSO:"Tau oligomers") positiveCorrelation path(MESH:Tauopathies) |
| pubmed:29686391 | a(CONSO:"Tau oligomers") positiveCorrelation path(MESH:Tauopathies) |
| pubmed:28420982 | a(CONSO:"Tau oligomers") increases path(MESH:Tauopathies) |
| pubmed:28420982 | a(CONSO:"Tau oligomers") increases path(MESH:Tauopathies) |
| pubmed:27574109 | a(CONSO:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27574109 | a(CONSO:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25887395 | a(CONSO:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:28420982 | a(CONSO:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26631930 | a(CONSO:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27574109 | a(CONSO:"Tau oligomers") positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pubmed:27574109 | a(CONSO:"Tau oligomers") positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pubmed:28528849 | a(CONSO:"Tau oligomers") decreases bp(GO:"long-term synaptic potentiation") |
| pubmed:28528849 | a(CONSO:"Tau oligomers") decreases bp(GO:memory) |
| pubmed:28420982 | a(CONSO:"Tau oligomers") decreases bp(GO:memory) |
| pubmed:29191965 | a(CONSO:"Tau oligomers") decreases a(MESH:Neurons) |
| pubmed:29686391 | a(CONSO:"Tau oligomers") positiveCorrelation path(CONSO:neurotoxicity) |
| pubmed:22817713 | a(CONSO:"Tau oligomers") increases path(CONSO:neurotoxicity) |
| pubmed:22817713 | a(CONSO:"Tau oligomers") increases path(CONSO:neurotoxicity) |
| pubmed:26671985 | act(a(CONSO:"Tau oligomers")) increases path(CONSO:neurotoxicity) |
| pubmed:26671985 | a(CONSO:"Tau oligomers") positiveCorrelation path(CONSO:neurotoxicity) |
| pubmed:29686391 | tloc(a(CONSO:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation a(CONSO:"Tau oligomers") |
| pubmed:29686391 | a(CONSO:"Tau oligomers") positiveCorrelation tloc(a(CONSO:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:30985105 | a(CONSO:"Tau oligomers") increases a(GO:"neurofibrillary tangle") |
| pubmed:28420982 | a(CONSO:"Tau oligomers") increases path(MESH:Disease) |
| pubmed:28420982 | a(CONSO:"Tau oligomers") increases bp(HP:Neurodegeneration) |
| pubmed:28420982 | a(CONSO:"Tau oligomers") increases bp(HP:Neurodegeneration) |
| pubmed:22817713 | a(CONSO:"Tau oligomers") increases bp(HP:Neurodegeneration) |
| pubmed:28420982 | a(CONSO:"Tau oligomers") increases path(MESH:"Brain Injuries, Traumatic") |
| pubmed:28420982 | a(CONSO:"Tau oligomers") decreases a(GO:synapse) |
| pubmed:28420982 | a(CONSO:"Tau oligomers") increases a(CONSO:"granular tau oligomers") |
| pubmed:28420982 | a(CONSO:"Tau oligomers") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pubmed:26631930 | a(CONSO:"Tau oligomers") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pubmed:28420982 | a(CONSO:"Tau oligomers") decreases bp(GO:cognition) |
| pubmed:28420982 | a(CONSO:"Tau oligomers") decreases bp(GO:"mitochondrion organization") |
| pubmed:28420982 | a(CONSO:"Tau oligomers") decreases bp(GO:"maintenance of synapse structure") |
| pubmed:28420982 | a(CONSO:"Tau oligomers") increases tloc(p(HGNC:MAPT), fromLoc(GO:"neuron part"), toLoc(GO:"neuron part")) |
| pubmed:28420982 | a(CONSO:"Tau oligomers") increases a(CONSO:"Tau annular protofibrils") |
| pubmed:28420982 | a(CONSO:"Tau oligomers") decreases bp(MESH:"Cell Survival") |
| pubmed:28420982 | a(CONSO:"Tau oligomers") association p(HGNC:PRNP) |
| pubmed:28420982 | a(CONSO:"Tau oligomers") decreases act(a(GO:microtubule)) |
| pubmed:28420982 | a(CONSO:"Tau oligomers") decreases a(MESH:"Electron Transport Complex I") |
| pubmed:28420982 | a(CONSO:"Tau oligomers") decreases act(a(MESH:"Electron Transport Complex I")) |
| pubmed:28420982 | a(CONSO:"Tau oligomers") decreases bp(GO:"ATP synthesis coupled proton transport") |
| pubmed:28420982 | a(CONSO:"Tau oligomers") increases act(p(HGNC:CASP9)) |
| pubmed:28420982 | a(CONSO:"Tau oligomers") increases tloc(p(HGNC:CYCS), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27373205 | a(CONSO:"Tau oligomers") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:22817713 | a(CONSO:"Tau oligomers") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:26631930 | a(CONSO:"Tau oligomers") increases path(CONSO:Neurodegeneration) |
| pubmed:26631930 | a(CONSO:"Tau oligomers") decreases a(MESH:"Dendritic Spines") |
| pubmed:22817713 | a(CONSO:"Tau oligomers") increases a(CONSO:"Tau aggregates") |
| pubmed:26751493 | a(CONSO:"Tau oligomers") increases a(CONSO:"Tau aggregates") |
| pubmed:22817713 | a(CONSO:"Tau oligomers") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:22817713 | a(CONSO:"Tau oligomers") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:29238289 | a(CONSO:"Tau oligomers") decreases path(MESH:Memory) |
| pubmed:29238289 | a(CONSO:"Tau oligomers") decreases bp(MESH:"Long-Term Potentiation") |
| pubmed:26671985 | act(a(CONSO:"Tau oligomers")) decreases act(complex(GO:axon)) |
| pubmed:26671985 | a(CONSO:"Tau oligomers") biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy") |
| pubmed:27716675 | a(CONSO:"Tau oligomers") positiveCorrelation path(CONSO:neuroinflammation) |
| pubmed:27716675 | a(CONSO:"Tau oligomers") increases path(CONSO:"Pathological Tau Spreading") |
| pubmed:27716675 | a(CONSO:"Tau oligomers") increases path(HP:Neurodegeneration) |
| pubmed:4255369 | a(CONSO:DC11) increases a(CONSO:"Tau oligomers") |
| pubmed:25478017 | a(CONSO:AADvac1) directlyIncreases complex(a(CONSO:AADvac1), p(CONSO:"Tau isoform F (441 aa)", frag("?"))) |
| pubmed:25478017 | a(CONSO:AADvac1) directlyIncreases complex(a(CONSO:AADvac1), p(CONSO:"4R tau", var("p.151_391del"))) |
| pubmed:25478017 | a(CONSO:AADvac1) directlyIncreases complex(a(CONSO:AADvac1), p(CONSO:"Tau isoform F (441 aa)")) |
| pubmed:25478017 | a(CONSO:AADvac1) directlyDecreases p(HGNC:MAPT, frag("?"), pmod(CONSO:hyperphosphorylation)) |
| pubmed:25478017 | a(CONSO:AADvac1) directlyDecreases p(CONSO:"Tau oligomers") |
| pubmed:25478017 | a(CONSO:AADvac1) decreases p(CONSO:"Tau oligomers") |
| pubmed:25478017 | a(CONSO:AADvac1) directlyDecreases p(HGNC:MAPT) |
| pubmed:25478017 | a(CONSO:AADvac1) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 217)) |
| pubmed:25478017 | a(CONSO:AADvac1) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:25478017 | a(CONSO:AADvac1) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:25478017 | a(CONSO:AADvac1) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:25478017 | a(CONSO:AADvac1) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) |
| pubmed:25478017 | a(CONSO:AADvac1) decreases path(MESH:Tauopathies) |
| pubmed:25478017 | a(CONSO:AADvac1) decreases complex(p(HGNC:MAPT), p(HGNC:MAPT)) |
| pubmed:25478017 | a(CONSO:AADvac1) decreases complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) |
| pubmed:25478017 | a(CONSO:AADvac1) decreases a(CONSO:"paired helical filaments") |
| pubmed:25478017 | a(CONSO:AADvac1) negativeCorrelation path(HP:"Sensorimotor neuropathy") |
| pubmed:25478017 | a(CONSO:AADvac1) causesNoChange path(MESH:"Erythrocyte Count") |
| pubmed:25478017 | a(CONSO:AADvac1) causesNoChange complex(GO:"hemoglobin complex") |
| pubmed:25478017 | a(CONSO:AADvac1) causesNoChange path(MESH:"Erythrocyte Indices") |
| pubmed:25478017 | a(CONSO:AADvac1) causesNoChange path(MESH:"Reticulocyte Count") |
| pubmed:25478017 | a(CONSO:AADvac1) causesNoChange path(MESH:"Platelet Count") |
| pubmed:25478017 | a(CONSO:AADvac1) causesNoChange path(MESH:"Leukocyte Count") |
| pubmed:25478017 | p(CONSO:"Tau isoform F (441 aa)", frag("?")) increases p(MESH:"Immunoglobulin G") |
| pubmed:25478017 | complex(a(CONSO:AADvac1), a(CONSO:DC8E8)) increases complex(GO:"immunoglobulin complex") |
| pubmed:25478017 | complex(GO:"immunoglobulin complex") positiveCorrelation complex(complex(GO:"immunoglobulin complex"), p(CONSO:"4R tau", var("p.151_391del"))) |
| pubmed:30988501 | complex(GO:"immunoglobulin complex") decreases path(DOID:"multiple sclerosis") |
| pubmed:25478017 | complex(complex(GO:"immunoglobulin complex"), p(CONSO:"4R tau", var("p.151_391del"))) positiveCorrelation complex(GO:"immunoglobulin complex") |
| pubmed:25478017 | bp(GO:"T-helper 2 cell activation") increases complex(a(MESH:"Immunoglobulin G"), p(CONSO:"4R tau", var("p.151_391del"))) |
| pubmed:17078951 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 217)) positiveCorrelation p(FPLX:PKA) |
| pubmed:22072628 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 217)) partOf p(CONSO:"proline-rich region 2", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:MAPT)) |
| pubmed:24653673 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:17403556 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22253473 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) decreases act(complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A))) |
| pubmed:24653673 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) decreases act(complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A))) |
| pubmed:10391244 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) association p(HGNC:PIN1, frag("5_39")) |
| pubmed:10391244 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) negativeCorrelation act(p(HGNC:MAPT), ma(GO:"microtubule binding")) |
| pubmed:21367866 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) positiveCorrelation p(HGNC:CDC37) |
| pubmed:17078951 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) positiveCorrelation p(FPLX:PKA) |
| pubmed:23948915 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) negativeCorrelation bp(GO:"apoptotic process") |
| pubmed:22833681 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) equivalentTo p(CONSO:"Tau epitope, AT180") |
| pubmed:22926167 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) increases a(CONSO:"Tau aggregates") |
| pubmed:22926167 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) increases a(GO:"neurofibrillary tangle") |
| pubmed:22299660 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29191965 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23088643 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:28784767 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) partOf p(CONSO:"Tau epitope, AT8") |
| pubmed:23088643 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) partOf p(CONSO:"Tau epitope, AT8") |
| pubmed:25331948 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) partOf p(CONSO:"Tau epitope, AT8") |
| pubmed:22833681 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) partOf p(CONSO:"Tau epitope, AT8") |
| pubmed:22817713 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) association a(CONSO:"Tau aggregates") |
| pubmed:22817713 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) association a(CONSO:"Tau oligomers") |
| pubmed:22486774 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) partOf a(CONSO:"Tau oligomers") |
| pubmed:14612456 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) isA p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:20071522 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) isA p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:20071522 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) association complex(p(HGNC:FKBP5), p(HGNC:MAPT)) |
| pubmed:20071522 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation p(HGNC:FKBP5) |
| pubmed:21367866 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation p(HGNC:CDC37) |
| pubmed:17078951 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation p(FPLX:PKA) |
| pubmed:28784767 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) increases p(CONSO:"Tau aggregates") |
| pubmed:25331948 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) equivalentTo p(CONSO:"Tau epitope, CP13") |
| pubmed:19459590 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) |
| pubmed:22833681 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) |
| pubmed:22833681 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:24406748 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) |
| pubmed:23294633 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pubmed:22002427 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Glu391*")) |
| pubmed:22253473 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) partOf a(GO:"neurofibrillary tangle") |
| pubmed:21734277 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:28784767 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) partOf p(CONSO:"Tau epitope, AT8") |
| pubmed:25331948 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) partOf p(CONSO:"Tau epitope, AT8") |
| pubmed:22833681 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) partOf p(CONSO:"Tau epitope, AT8") |
| pubmed:24760868 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) increases p(HGNC:MAPT, loc(MESH:"Dendritic Spines")) |
| pubmed:29191965 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22817713 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) association a(CONSO:"Tau aggregates") |
| pubmed:22817713 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) association a(CONSO:"Tau oligomers") |
| pubmed:22486774 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) partOf a(CONSO:"Tau oligomers") |
| pubmed:14612456 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) isA p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:17078951 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) positiveCorrelation p(FPLX:PKA) |
| pubmed:28784767 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) increases p(CONSO:"Tau aggregates") |
| pubmed:19459590 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) |
| pubmed:22833681 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) |
| pubmed:22833681 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:24406748 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) |
| pubmed:23294633 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pubmed:22253473 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) partOf a(GO:"neurofibrillary tangle") |
| pubmed:21734277 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:28420982 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) association a(MESH:Exosomes) |
| pubmed:28420982 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:28420982 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pubmed:17078951 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) positiveCorrelation p(FPLX:PKA) |
| pubmed:11943212 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) partOf p(CONSO:"Tau epitope, AT270") |
| pubmed:25478017 | complex(p(HGNC:MAPT), p(HGNC:MAPT)) increases path(MESH:Tauopathies) |
| pubmed:25887395 | complex(p(HGNC:MAPT), p(HGNC:MAPT)) causesNoChange tloc(a(CONSO:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:25887395 | complex(p(HGNC:MAPT), p(HGNC:MAPT)) causesNoChange a(CONSO:"Tau aggregates") |
| pubmed:22817713 | complex(p(HGNC:MAPT), p(HGNC:MAPT)) increases a(CONSO:"Tau oligomers") |
| pubmed:25478017 | complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) increases path(MESH:Tauopathies) |
| pubmed:25887395 | complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) increases tloc(a(CONSO:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:25887395 | complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) increases a(CONSO:"Tau aggregates") |
| pubmed:29988016 | complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) increases a(CONSO:"Tau aggregates") |
| pubmed:22299660 | a(CONSO:"paired helical filaments") negativeCorrelation act(p(FPLX:PPP2)) |
| pubmed:14556719 | a(CONSO:"paired helical filaments") decreases act(complex(GO:"proteasome complex")) |
| pubmed:22908190 | a(CONSO:"paired helical filaments") negativeCorrelation act(complex(GO:"proteasome complex")) |
| pubmed:22908190 | a(CONSO:"paired helical filaments") association a(GO:"neurofibrillary tangle") |
| pubmed:22908190 | a(CONSO:"paired helical filaments") association a(CONSO:"dystrophic neurite") |
| pubmed:22908190 | a(CONSO:"paired helical filaments") association p(HGNC:MAPT) |
| pubmed:22908190 | a(CONSO:"paired helical filaments") association p(HGNC:MAPT) |
| pubmed:22908190 | a(CONSO:"paired helical filaments") association a(MESH:Ubiquitin) |
| pubmed:22908190 | a(CONSO:"paired helical filaments") association p(CONSO:"Tau isoform F (441 aa)", pmod(go:0016567 ! "protein ubiquitination", Lys, 254)) |
| pubmed:22908190 | a(CONSO:"paired helical filaments") association p(CONSO:"Tau isoform F (441 aa)", pmod(go:0016567 ! "protein ubiquitination", Lys, 257)) |
| pubmed:22908190 | a(CONSO:"paired helical filaments") association p(CONSO:"Tau isoform F (441 aa)", pmod(go:0016567 ! "protein ubiquitination", Lys, 311)) |
| pubmed:22908190 | a(CONSO:"paired helical filaments") association p(CONSO:"Tau isoform F (441 aa)", pmod(go:0016567 ! "protein ubiquitination", Lys, 317)) |
| pubmed:22908190 | a(CONSO:"paired helical filaments") association p(CONSO:"Tau isoform F (441 aa)", pmod(go:0070936 ! "protein K48-linked ubiquitination")) |
| pubmed:22908190 | a(CONSO:"paired helical filaments") association p(CONSO:"Tau isoform F (441 aa)", pmod(go:0070936 ! "protein K48-linked ubiquitination")) |
| pubmed:22908190 | a(CONSO:"paired helical filaments") association p(CONSO:"Tau isoform F (441 aa)", pmod(go:0000209 ! "protein polyubiquitination", Lys, 6)) |
| pubmed:22908190 | a(CONSO:"paired helical filaments") association p(CONSO:"Tau isoform F (441 aa)", pmod(go:0000209 ! "protein polyubiquitination", Lys, 11)) |
| pubmed:26631930 | a(CONSO:"paired helical filaments") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) |
| pubmed:26631930 | a(CONSO:"paired helical filaments") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 394)) |
| pubmed:26631930 | a(CONSO:"paired helical filaments") association p(HGNC:MAPT, pmod(CONSO:glycation)) |
| pubmed:26631930 | a(CONSO:"paired helical filaments") association p(HGNC:MAPT, pmod(CONSO:deamidation)) |
| pubmed:26631930 | a(CONSO:"paired helical filaments") association p(HGNC:MAPT, pmod(GO:"protein peptidyl-prolyl isomerization")) |
| pubmed:17050703 | a(CONSO:"paired helical filaments") association p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) |
| pubmed:16566606 | a(CONSO:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) |
| pubmed:16566606 | a(CONSO:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) |
| pubmed:16566606 | a(CONSO:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) |
| pubmed:16566606 | a(CONSO:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) |
| pubmed:16566606 | a(CONSO:"paired helical filaments") positiveCorrelation a(CONSO:"3-3 dityrosine cross-linking") |
| pubmed:26501932 | a(CONSO:"paired helical filaments") partOf a(CONSO:pretangles) |
| pubmed:7667312 | a(CONSO:"paired helical filaments") positiveCorrelation a(CONSO:"Thioflavin S") |
| pubmed:7667312 | a(CONSO:"paired helical filaments") partOf complex(GO:"neurofibrillary tangle") |
| pubmed:8391280 | a(CONSO:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination", Lys, 254)) |
| pubmed:8391280 | a(CONSO:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination", Lys, 257)) |
| pubmed:8391280 | a(CONSO:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination", Lys, 311)) |
| pubmed:25478017 | a(CONSO:"Tau antibody, HT7") increases complex(a(CONSO:"Tau antibody, HT7"), a(CONSO:"Tau fibrils")) |
| pubmed:28408124 | a(CONSO:"Tau antibody, HT7") decreases p(MGI:Mapt, loc(GO:cell)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, HT7") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, HT7") decreases p(HGNC:MAPT, loc(GO:cell)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, HT7") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:25478017 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) increases complex(a(CONSO:"Tau fibrils"), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214))) |
| pubmed:25478017 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) decreases a(CONSO:"Tau fibrils") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:8226987 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) |
| pubmed:25478017 | path(HP:"Sensorimotor neuropathy") negativeCorrelation a(CONSO:AADvac1) |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") |
| pubmed:30664622 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:DLG4) |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:DLG4) |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases a(GO:"excitatory synapse") |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases a(GO:"excitatory synapse") |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates complex(p(HGNC:ADNP), p(HGNC:DLG4)) |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates complex(p(HGNC:ADNP), p(HGNC:AKT1)) |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:FPR3) |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:TUBB1) |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates act(p(HGNC:LIPA)) |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:HIST1H3B) |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates p(HGNC:HIST1H3B) |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:ABCF3) |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:BMP4) |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:CDH17) |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:KDM5D) |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:KLF1) |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:PER1) |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:AKT1) |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:AIF1) |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:"Psychomotor Performance") |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:"Psychomotor Performance") |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Vestibular Diseases") |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) negativeCorrelation bp(MESH:"Body Height") |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) negativeCorrelation path(MESH:"Weight Gain") |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:"Motor Activity") |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange path(MESH:"Motor Activity") |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(MESH:"Hand Strength") |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange bp(MESH:"Hand Strength") |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Autistic Disorder") |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:Smell) |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange path(MESH:Smell) |
| pubmed:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(GO:"social behavior") |
| pubmed:30664622 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(GO:"social behavior") |
| pubmed:30664622 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(GO:"social behavior") |
| pubmed:30664622 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(GO:memory) |
| pubmed:30664622 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Motor Skills Disorders") |
| pubmed:30664622 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Brain Injuries") |
| pubmed:30664622 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(MESH:"Nerve Fibers, Myelinated") |
| pubmed:30664622 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange p(HGNC:SLC17A7) |
| pubmed:30664622 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:SLC17A7) |
| pubmed:30664622 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:SLC17A7) |
| pubmed:30664622 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases r(HGNC:SLC17A7) |
| pubmed:30008470 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases r(HGNC:ADNP) |
| pubmed:30008470 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Alcohol Drinking") |
| pubmed:30008470 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange path(MESH:"Alcohol Drinking") |
| pubmed:30008470 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Alcohol Drinking") |
| pubmed:30008470 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Alcohol Drinking") |
| pubmed:30008470 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:"Alcohol Drinking") |
| pubmed:30008470 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange tloc(a(CHEBI:saccharin), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) |
| pubmed:30008470 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange tloc(a(CHEBI:quinine), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) |
| pubmed:30008470 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:TFAP2B) |
| pubmed:30008470 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:TFAP2B) |
| pubmed:30106381 | composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases a(GO:"dendritic spine") |
| pubmed:30106381 | composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:"Recognition (Psychology)") |
| pubmed:30664622 | composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) increases path(MESH:Smell) |
| pubmed:30664622 | composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:Smell) |
| pubmed:30008470 | composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:"Alcohol Drinking") |
| pubmed:30106381 | bp(GO:"AMPA glutamate receptor clustering") association p(HGNC:ADNP) |
| pubmed:30106381 | bp(GO:"social behavior") association p(HGNC:ADNP) |
| pubmed:30106381 | bp(GO:"vocalization behavior") association p(HGNC:ADNP) |
| pubmed:30106381 | p(HGNC:AKT1, var("?")) increases path(MESH:"Proteus Syndrome") |
| pubmed:30106381 | g(HGNC:IQCJ-SCHIP1) increases bp(GO:"calcium-mediated signaling") |
| pubmed:30106381 | g(HGNC:IQCJ-SCHIP1) increases bp(GO:"action potential") |
| pubmed:30106381 | g(HGNC:IQCJ-SCHIP1) increases bp(MESH:"Neuronal Outgrowth") |
| pubmed:30106381 | g(HGNC:IQCJ-SCHIP1) association p(HGNC:ADNP) |
| pubmed:30106381 | g(HGNC:IQCJ-SCHIP1) association a(PUBCHEM:9832404) |
| pubmed:30106381 | p(HGNC:LIPA) increases bp(GO:"lipid metabolic process") |
| pubmed:22142809 | p(HGNC:LIPA) negativeCorrelation p(CONSO:RAC1b) |
| pubmed:22142809 | p(HGNC:LIPA) association bp(GO:"regulation of cell cycle") |
| pubmed:30106381 | g(HGNC:LIPA) association a(PUBCHEM:9832404) |
| pubmed:30106381 | p(HGNC:NLGN2) association a(PUBCHEM:9832404) |
| pubmed:30106381 | p(HGNC:NLGN2) association p(HGNC:ADNP) |
| pubmed:30106381 | p(HGNC:NLGN2) increases bp(GO:"synapse organization") |
| pubmed:30106381 | p(HGNC:PAX6) association a(PUBCHEM:9832404) |
| pubmed:30106381 | p(HGNC:PAX6) regulates bp(GO:"glutamatergic neuron differentiation") |
| pubmed:30106381 | p(HGNC:WFS1) association path(CONSO:Neurodegeneration) |
| pubmed:30106381 | p(HGNC:WFS1) regulates bp(GO:"cellular calcium ion homeostasis") |
| pubmed:30106381 | p(HGNC:WFS1) association p(HGNC:ADNP) |
| pubmed:30106381 | path(MESH:Intelligence) association p(HGNC:ADNP) |
| pubmed:30106381 | p(HGNC:AIF1) association bp(GO:"microglial cell activation") |
| pubmed:26010758 | p(HGNC:AIF1) positiveCorrelation bp(GO:"microglial cell activation") |
| pubmed:30106381 | bp(MESH:"Body Height") negativeCorrelation p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) |
| pubmed:30106381 | path(MESH:"Weight Gain") negativeCorrelation p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) |
| pubmed:30664622 | path(MESH:Smell) regulates bp(GO:"social behavior") |
| pubmed:30664622 | a(CHEBI:chlorobutanol) increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain)) |
| pubmed:30664622 | a(CHEBI:chlorobutanol) increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:"Cell Body")) |
| pubmed:30664622 | a(CHEBI:chlorobutanol) increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain)) |
| pubmed:30664622 | a(CHEBI:chlorobutanol) causesNoChange a(MESH:"Blood-Brain Barrier") |
| pubmed:30664622 | a(CHEBI:chlorobutanol) increases bp(GO:"social behavior") |
| pubmed:30664622 | a(CHEBI:chlorobutanol) causesNoChange path(MESH:Smell) |
| pubmed:30664622 | a(CHEBI:chlorobutanol) decreases path(MESH:Smell) |
| pubmed:30664622 | a(CHEBI:"Evans blue") causesNoChange tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain)) |
| pubmed:30664622 | a(CHEBI:"Evans blue") increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(GO:"cell periphery")) |
| pubmed:30664622 | a(CHEBI:"Evans blue") causesNoChange tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain)) |
| pubmed:30664622 | composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404)) increases bp(GO:memory) |
| pubmed:30664622 | composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404)) increases bp(GO:"social behavior") |
| pubmed:30664622 | composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404)) increases a(MESH:"Nerve Fibers, Myelinated") |
| pubmed:30664622 | composite(a(PUBCHEM:59557), a(PUBCHEM:9832404)) decreases bp(GO:"social behavior") |
| pubmed:30664622 | composite(a(CHEBI:chlorobutanol), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:Smell) |
| pubmed:30664622 | composite(a(CHEBI:chlorobutanol), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) increases path(MESH:Smell) |
| pubmed:30664622 | p(HGNC:SLC17A7) regulates bp(GO:"glutamate homeostasis") |
| pubmed:30664622 | p(HGNC:SLC17A7) increases bp(GO:"L-glutamate import") |
| pubmed:30664622 | p(HGNC:SLC17A7) association a(GO:"asymmetric, glutamatergic, excitatory synapse") |
| pubmed:30664622 | a(GO:"asymmetric, glutamatergic, excitatory synapse") association p(HGNC:SLC17A7) |
| pubmed:29724491 | p(HGNC:ADNP, frag("1_719")) decreases bp(GO:"walking behavior") |
| pubmed:29724491 | p(HGNC:ADNP, var("?")) increases path(MESH:"Muscle Hypotonia") |
| pubmed:29724491 | p(HGNC:ADNP, var("?")) increases path(MESH:"Muscle Hypertonia") |
| pubmed:29724491 | p(HGNC:ADNP, var("?")) increases path(MESH:"Language Development Disorders") |
| pubmed:29724491 | p(HGNC:ADNP, var("?")) increases path(MESH:Seizures) |
| pubmed:29724491 | p(HGNC:ADNP, var("?")) increases path(MESH:Epilepsy) |
| pubmed:29724491 | p(HGNC:ADNP, var("?")) increases path(MESH:"Autistic Disorder") |
| pubmed:29724491 | p(HGNC:ADNP, var("?")) decreases path(MESH:"Autism Spectrum Disorder") |
| pubmed:29724491 | p(HGNC:ADNP, var("?")) decreases bp(GO:"sensory processing") |
| pubmed:29724491 | p(HGNC:ADNP, var("?")) increases path(MESH:"Compulsive Behavior") |
| pubmed:29724491 | p(HGNC:ADNP, var("?")) association path(MESH:"Mood Disorders") |
| pubmed:29724491 | p(HGNC:ADNP, var("?")) increases path(MESH:Anxiety) |
| pubmed:29724491 | p(HGNC:ADNP, var("?")) association path(MESH:Morale) |
| pubmed:29724491 | p(HGNC:ADNP, var("?")) association path(MESH:"Self-Injurious Behavior") |
| pubmed:29724491 | p(HGNC:ADNP, var("?")) association path(MESH:Aggression) |
| pubmed:29724491 | p(HGNC:ADNP, var("?")) increases path(MESH:"Attention Deficit Disorder with Hyperactivity") |
| pubmed:29724491 | p(HGNC:ADNP, var("?")) decreases bp(GO:sleep) |
| pubmed:29724491 | p(HGNC:ADNP, var("?")) increases path(MESH:"Malformations of Cortical Development") |
| pubmed:29724491 | p(HGNC:ADNP, var("?")) decreases path(MESH:"Vision, Ocular") |
| pubmed:29724491 | p(HGNC:ADNP, var("?")) increases path(MESH:Hyperopia) |
| pubmed:29724491 | p(HGNC:ADNP, var("?")) increases path(MESH:Strabismus) |
| pubmed:29724491 | p(HGNC:ADNP, var("?")) increases path(MESH:Myopia) |
| pubmed:29724491 | p(HGNC:ADNP, var("?")) increases path(MESH:Astigmatism) |
| pubmed:29724491 | path(MESH:Morale) association p(HGNC:ADNP, var("?")) |
| pubmed:29724491 | path(MESH:"Self-Injurious Behavior") association p(HGNC:ADNP, var("?")) |
| pubmed:29724491 | path(MESH:Aggression) association p(HGNC:ADNP, var("?")) |
| pubmed:30008470 | path(MESH:"Alcohol Drinking") increases r(HGNC:ADNP) |
| pubmed:30008470 | path(MESH:"Alcohol Drinking") increases r(HGNC:ADNP) |
| pubmed:30008470 | path(MESH:"Alcohol Drinking") increases p(HGNC:ADNP) |
| pubmed:30008470 | path(MESH:"Alcohol Drinking") causesNoChange p(HGNC:ADNP) |
| pubmed:30008470 | path(MESH:"Alcohol Drinking") causesNoChange p(HGNC:ADNP) |
| pubmed:30008470 | path(MESH:"Alcohol Drinking") decreases p(HGNC:ADNP) |
| pubmed:30008470 | path(MESH:"Alcohol Drinking") causesNoChange p(HGNC:ADNP) |
| pubmed:30008470 | path(MESH:"Alcohol Drinking") negativeCorrelation g(HGNC:ADNP) |
| pubmed:30008470 | path(MESH:"Alcohol Drinking") decreases p(HGNC:TFAP2B) |
| pubmed:30008470 | g(HGNC:ADNP) negativeCorrelation path(MESH:"Alcohol Drinking") |
| pubmed:22807490 | path(MESH:"Hashimoto Disease") association path(MESH:Smoking) |
| pubmed:22807490 | p(HGNC:TPO) negativeCorrelation path(MESH:Smoking) |
| pubmed:22807490 | path(MESH:"Thyroiditis, Autoimmune") increases p(HGNC:IL1R2) |
| pubmed:22807490 | path(MESH:"Thyroiditis, Autoimmune") increases p(HGNC:IL18) |
| pubmed:21958873 | a(PUBCHEM:71311633) causesNoChange a(CHEBI:amyloid-beta) |
| pubmed:21958873 | a(PUBCHEM:71311633) increases act(a(MESH:"Receptors, Nicotinic")) |
| pubmed:21958873 | a(PUBCHEM:56972222) causesNoChange a(CHEBI:amyloid-beta) |
| pubmed:21958873 | a(PUBCHEM:56972222) increases act(a(MESH:"Receptors, Nicotinic")) |
| pubmed:21958873 | a(PUBCHEM:11957537) causesNoChange a(CHEBI:amyloid-beta) |
| pubmed:21958873 | a(PUBCHEM:11957537) decreases act(a(MESH:"Receptors, Nicotinic")) |
| pubmed:30988501 | p(HGNC:CRP) negativeCorrelation path(DOID:schizophrenia) |
| pubmed:30988501 | p(HGNC:CRP) negativeCorrelation path(DOID:"mental depression") |
| pubmed:30988501 | p(HGNC:CRP) negativeCorrelation path(DOID:"post-traumatic stress disorder") |
| pubmed:23178521 | a(CHEBI:stattic) decreases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:stattic) decreases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | a(CHEBI:stattic) decreases complex(p(HGNC:STAT3), p(HGNC:STAT3)) |
| pubmed:23178521 | a(CHEBI:stattic) decreases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23178521 | composite(a(CHEBI:Anatabine), a(MESH:Blood)) decreases p(HGNC:IL1B) |
| pubmed:23178521 | composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide), a(MESH:Blood)) decreases p(HGNC:IL1B) |
| pubmed:23383175 | p(MGI:Il1b) positiveCorrelation path(MESH:Encephalomyelitis) |
| pubmed:23383175 | p(MGI:Il6) positiveCorrelation path(MESH:Encephalomyelitis) |
| pubmed:23383175 | p(MGI:Tnf) positiveCorrelation path(MESH:Encephalomyelitis) |
| pubmed:23178521 | composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il1b) |
| pubmed:23178521 | composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il1b) |
| pubmed:23178521 | composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf) |
| pubmed:23178521 | composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf) |
| pubmed:23178521 | composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf) |
| pubmed:23178521 | composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il6) |
| pubmed:23178521 | composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il6) |
| pubmed:23383175 | p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation path(MESH:Encephalomyelitis) |
| pubmed:23383175 | p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation path(MESH:Encephalomyelitis) |
| pubmed:23383175 | p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation path(MESH:Encephalomyelitis) |
| pubmed:23383175 | p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) association path(MESH:"Neurologic Manifestations") |
| pubmed:23383175 | p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(MGI:Rela, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23383175 | p(MGI:Stat3) regulates bp(GO:"cytokine production") |
| pubmed:23383175 | path(MESH:Encephalomyelitis) negativeCorrelation a(CHEBI:Anatabine) |
| pubmed:23383175 | path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il1b) |
| pubmed:23383175 | path(MESH:Encephalomyelitis) increases p(MGI:Il1b) |
| pubmed:23383175 | path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Ifng) |
| pubmed:23383175 | path(MESH:Encephalomyelitis) increases p(MGI:Ifng) |
| pubmed:23383175 | path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Tnf) |
| pubmed:23383175 | path(MESH:Encephalomyelitis) increases p(MGI:Tnf) |
| pubmed:23383175 | path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il6) |
| pubmed:23383175 | path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il17a) |
| pubmed:23383175 | path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23383175 | path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23383175 | path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23383175 | path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23383175 | path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23383175 | path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23383175 | path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23383175 | path(MESH:Encephalomyelitis) increases p(MGI:Rela, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23383175 | path(MESH:Encephalomyelitis) increases bp(CONSO:Astrogliosis) |
| pubmed:23383175 | path(MESH:Encephalomyelitis) increases bp(CONSO:Astrogliosis) |
| pubmed:23383175 | path(MESH:Encephalomyelitis) increases bp(CONSO:Microgliosis) |
| pubmed:23383175 | path(MESH:Encephalomyelitis) increases tloc(a(MESH:Leukocytes), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) |
| pubmed:23383175 | path(MESH:Encephalomyelitis) increases a(MESH:Microglia) |
| pubmed:23383175 | path(MESH:Encephalomyelitis) decreases a(GO:"myelin sheath") |
| pubmed:23383175 | p(MGI:Ifng) positiveCorrelation path(MESH:Encephalomyelitis) |
| pubmed:23383175 | p(MGI:Il17a) positiveCorrelation path(MESH:Encephalomyelitis) |
| pubmed:23383175 | p(MGI:Rela, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23383175 | p(MGI:Rela) regulates bp(GO:"cytokine production") |
| pubmed:23383175 | bp(CONSO:Astrogliosis) negativeCorrelation a(GO:"myelin sheath") |
| pubmed:23383175 | bp(CONSO:Microgliosis) negativeCorrelation a(GO:"myelin sheath") |
| pubmed:12428809 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) association path(MESH:"Alzheimer Disease") |
| pubmed:21882945 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| doi:"10.4172/2168-975X.1000126" | p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation", Ser, 473)) increases act(p(FPLX:AKT)) |
| pubmed:23454242 | p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation", Ser, 473)) increases act(p(FPLX:AKT)) |
| pubmed:29121589 | p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation", Ser, 473)) increases act(p(FPLX:AKT)) |
| pubmed:29121589 | p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation", Ser, 473)) positiveCorrelation a(CHEBI:"dimethyl fumarate") |
| pubmed:28391535 | tloc(a(CHEBI:adrenaline), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases tloc(a(CHEBI:glucose), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28391535 | tloc(a(CHEBI:adrenaline), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases path(MESH:"Blood Pressure") |
| pubmed:28391535 | tloc(a(CHEBI:adrenaline), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases bp(GO:"cellular respiration") |
| pubmed:28391535 | tloc(a(CHEBI:adrenaline), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases bp(MESH:"Heart Rate") |
| pubmed:28391535 | complex(p(GO:"I-kappaB/NF-kappaB complex")) association a(CHEBI:nicotine) |
| pubmed:28391535 | a(CHEBI:"(S)-nicotine") increases a(MESH:"Toxic Actions") |
| pubmed:28391535 | a(CHEBI:"(S)-nicotine") increases path(MESH:Death) |
| pubmed:28391535 | a(CHEBI:"(R)-nicotine") increases a(MESH:"Toxic Actions") |
| pubmed:28391535 | a(CHEBI:"(R)-nicotine") increases path(MESH:Death) |
| pubmed:28391535 | a(MESH:Tobacco) isA a(CHEBI:nornicotine) |
| pubmed:28391535 | a(MESH:Liver) increases bp(GO:"nicotine metabolic process") |
| pubmed:29626319 | a(MESH:Liver) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | a(MESH:Liver) decreases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | a(MESH:Liver) decreases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | a(MESH:Liver) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pubmed:29626319 | a(MESH:Liver) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:28391535 | bp(GO:"nicotine metabolic process") increases a(CHEBI:"(-)-cotinine") |
| pubmed:28391535 | bp(GO:"nicotine metabolic process") increases a(CHEBI:nornicotine) |
| pubmed:28391535 | a(MESH:Lung) increases bp(GO:"nicotine metabolic process") |
| pubmed:28391535 | a(CHEBI:lactam) association a(CHEBI:"(-)-cotinine") |
| pubmed:26195256 | path(MESH:Hypertension) increases path(MESH:"Alzheimer Disease") |
| pubmed:28391535 | a(PUBCHEM:4032) decreases path(MESH:"Behavior, Addictive") |
| pubmed:28391535 | a(PUBCHEM:4032) decreases path(MESH:Smoking) |
| pubmed:28391535 | a(CHEBI:Hexamethonium) increases tloc(a(CHEBI:Hexamethonium), fromLoc(GO:"extracellular region"), toLoc(MESH:"Central Nervous System")) |
| pubmed:28391535 | a(CHEBI:Hexamethonium) negativeCorrelation act(a(CHEBI:nicotine)) |
| pubmed:28391535 | a(CHEBI:"(-)-lobeline") increases complex(a(CHEBI:"(-)-lobeline"), a(MESH:"nicotinic receptor alpha4beta2")) |
| pubmed:28391535 | a(CHEBI:"(-)-lobeline") decreases act(a(CHEBI:nicotine)) |
| pubmed:28391535 | a(CHEBI:"(-)-lobeline") decreases act(a(PUBCHEM:9306)) |
| pubmed:19165623 | complex(a(CHEBI:"nicotinic acid"), a(CHEBI:1-methylpyrrolinium)) increases a(CHEBI:nicotine) |
| pubmed:19165623 | a(CHEBI:arginine) increases a(CHEBI:1-methylpyrrolinium) |
| pubmed:19165623 | a(CHEBI:ornithine) increases a(CHEBI:1-methylpyrrolinium) |
| pubmed:19165623 | a(UNIPROT:Q9SEH4) increases a(CHEBI:nicotine) |
| pubmed:19165623 | a(UNIPROT:Q9SEH4) increases a(CHEBI:nicotine) |
| pubmed:19165623 | a(UNIPROT:Q9SEH4) increases rxn(reactants(a(CHEBI:arginine), a(CHEBI:ornithine)), products(a(CHEBI:1-methylpyrrolinium))) |
| pubmed:19165623 | a(UNIPROT:Q9SEH4) decreases a(CHEBI:Anatabine) |
| pubmed:19165623 | p(HGNC:QPRT) increases rxn(reactants(a(CHEBI:"quinolinic acid")), products(a(CHEBI:"nicotinic acid"))) |
| pubmed:19165623 | p(HGNC:QPRT) regulates rxn(reactants(a(CHEBI:"nicotinic acid")), products(a(CHEBI:Anatabine))) |
| pubmed:19165623 | p(HGNC:QPRT) increases a(CHEBI:Anatabine) |
| pubmed:19165623 | p(HGNC:QPRT) increases a(CHEBI:nicotine) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases act(p(HGNC:NFE2L2)) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases act(p(HGNC:NFE2L2)) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases act(p(HGNC:NFE2L2)) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:SIRT1) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:SLC7A11) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:AKR1B10) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:PTGR1) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:HMOX1) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:HMOX1) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:HMOX1) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:AIFM2) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:OSGIN1) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:GPX3) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:SQSTM1) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:HSPB8) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:TNFSF9) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:CTNNB1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:DHFR) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:DHFR) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:EDN1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:ITGB3) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:MKI67) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:MMP11) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:MMP14) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:MMP2) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:PDE7A) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:PDE7B) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:PLAU) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:PTGS1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:PTGS1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:SCARB1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:TUBB3) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:TUBB3) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:TUBB3) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:NR3C1) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:NR3C1) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:PPARA) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:PPARA) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:EGR1) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:PTGS2) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:PTGS2) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:SOAT1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:ACLY) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:ACLY) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:ANTXR1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:C20orf27) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:CCNA2) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:CHAF1A) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:EFCAB11) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:FEN1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:GINS2) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:MCM10) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:MCM4) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:RNASEH2A) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:SLIT2) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:SPC25) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:TFRC) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:TK1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:TMEM97) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:TRIP13) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:TUBB) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:TUBB) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:TYMS) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:UBA1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:UNG) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:UNG) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:VRK1) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:ABCD3) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:GLRX2) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:GLRX2) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:MICB) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:NQO1) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:NQO1) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:NQO1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:TYMS) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:AGRN) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:ANP32A) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:BAX) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:BCHE) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:BGN) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:BRCA1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:CADPS2) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:CAPN1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:CCNB1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:CDK1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:CDK2) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:CDKN2A) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:CXCR4) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:EIF4EBP1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:FOLH1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:HOMER1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:HRH1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:IGF2) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:IGFBP2) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:LDLR) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:MAOA) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:NEFH) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:NPDC1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:NRGN) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:PREP) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:PROS1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:SELENBP1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:TAGLN) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:TGFB1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:VKORC1) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:CANX) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:GCNT2) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:IDE) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:MMP1) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:NFE2L2) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:SLC6A6) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:SYVN1) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:TSHZ1) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:TXN) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:ATAD2) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:BECN1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:DHCR24) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:FGF2) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:HTRA1) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:PRKCE) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:PRKDC) |
| pubmed:22020111 | a(PUBCHEM:135316034) decreases g(HGNC:SCD) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:ATP1A1) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:CTSD) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:GLRX) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:GLRX) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:IL6R) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:NPTX1) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:PHF1) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:PRKCD) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:RANBP9) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:SOD1) |
| pubmed:22020111 | a(PUBCHEM:135316034) increases g(HGNC:SOD1) |
| pubmed:22020111 | a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) |
| pubmed:22020111 | a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) |
| pubmed:22020111 | a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) |
| pubmed:22020111 | a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) |
| pubmed:22020111 | a(PUBCHEM:400769) increases bp(GO:"glomerular filtration") |
| pubmed:22020111 | a(PUBCHEM:400769) negativeCorrelation path(MESH:"Multiple Sclerosis, Relapsing-Remitting") |
| pubmed:22020111 | p(HGNC:SLC7A11) regulates bp(GO:"glutamate homeostasis") |
| pubmed:22020111 | p(HGNC:SLC7A11) increases tloc(a(CHEBI:cystine), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:30837838 | a(CHEBI:glutathione) decreases deg(p(HGNC:TARDBP)) |
| pubmed:30837838 | a(CHEBI:glutathione) decreases p(HGNC:TARDBP, frag("?"), loc(GO:"cortical granule")) |
| pubmed:30837838 | a(CHEBI:glutathione) decreases p(CONSO:"TDP-43 aggregates") |
| pubmed:30837838 | a(CHEBI:glutathione) decreases a(CHEBI:"reactive oxygen species") |
| pubmed:30837838 | a(CHEBI:glutathione) decreases path(MESH:"Cell Death") |
| pubmed:22020111 | p(HGNC:AKR1B10) increases bp(GO:detoxification) |
| pubmed:22020111 | p(HGNC:AKR1B10) decreases a(PUBCHEM:5283344) |
| pubmed:22020111 | p(HGNC:PTGR1) decreases act(a(MESH:Prostaglandins)) |
| pubmed:22020111 | p(HGNC:PTGR1) decreases act(a(MESH:Eicosanoids)) |
| pubmed:22020111 | g(HGNC:HMOX1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22020111 | p(HGNC:AIFM2) increases path(MESH:Apoptosis) |
| pubmed:22020111 | p(HGNC:AIFM2) negativeCorrelation path(MESH:Neoplasms) |
| pubmed:28669544 | path(MESH:Apoptosis) increases a(NCIT:C120869) |
| pubmed:22020111 | p(HGNC:OSGIN1) decreases path(MESH:Neoplasms) |
| pubmed:22020111 | p(HGNC:GPX3) negativeCorrelation path(MESH:Neoplasms) |
| pubmed:22020111 | p(HGNC:HSPB8) increases complex(p(HGNC:BAG3), p(HGNC:HSPB8)) |
| pubmed:27491084 | p(HGNC:HSPB8) association a(CONSO:"amyloid-beta aggregates") |
| pubmed:24563850 | p(HGNC:HSPB8) increases bp(GO:"chaperone-mediated autophagy") |
| pubmed:24563850 | p(HGNC:HSPB8) association p(HGNC:EIF2A) |
| pubmed:22020111 | complex(p(HGNC:BAG3), p(HGNC:HSPB8)) positiveCorrelation bp(GO:autophagy) |
| pubmed:22020111 | complex(p(HGNC:BAG3), p(HGNC:HSPB8)) increases deg(a(CONSO:"protein aggregates")) |
| pubmed:25036637 | p(HGNC:BAG3) increases complex(p(HGNC:BAG3), p(HGNC:HSPB8)) |
| pubmed:23746257 | p(HGNC:BAG3) increases bp(GO:macroautophagy) |
| pubmed:25036637 | p(HGNC:BAG3) increases complex(p(HGNC:BAG3), p(HGNC:HSPB1)) |
| pubmed:25036637 | p(HGNC:BAG3) directlyIncreases complex(p(HGNC:BAG3), p(HGNC:HSPB1)) |
| pubmed:25036637 | p(HGNC:BAG3) increases complex(p(HGNC:BAG3), p(HGNC:HSF1)) |
| pubmed:25036637 | p(HGNC:BAG3) directlyIncreases complex(p(HGNC:BAG3), p(HGNC:DCP1B)) |
| pubmed:29626319 | p(HGNC:BAG3) increases deg(p(HGNC:MAPT)) |
| pubmed:22020111 | p(HGNC:TNFSF9) increases act(a(MESH:"Dendritic Cells")) |
| pubmed:22020111 | p(HGNC:TNFSF9) increases bp(GO:"T cell activation") |
| pubmed:22020111 | path(MESH:Atherosclerosis) increases g(HGNC:CTNNB1) |
| pubmed:22020111 | path(MESH:Atherosclerosis) increases g(HGNC:DHFR) |
| pubmed:22020111 | path(MESH:Atherosclerosis) increases g(HGNC:EDN1) |
| pubmed:22020111 | path(MESH:Atherosclerosis) increases g(HGNC:ITGB3) |
| pubmed:22020111 | path(MESH:Atherosclerosis) increases g(HGNC:MKI67) |
| pubmed:22020111 | path(MESH:Atherosclerosis) increases g(HGNC:MMP11) |
| pubmed:22020111 | path(MESH:Atherosclerosis) increases g(HGNC:MMP14) |
| pubmed:22020111 | path(MESH:Atherosclerosis) increases g(HGNC:MMP2) |
| pubmed:22020111 | path(MESH:Atherosclerosis) increases g(HGNC:PDE7A) |
| pubmed:22020111 | path(MESH:Atherosclerosis) increases g(HGNC:PDE7B) |
| pubmed:22020111 | path(MESH:Atherosclerosis) increases g(HGNC:PLAU) |
| pubmed:22020111 | path(MESH:Atherosclerosis) increases g(HGNC:PTGS1) |
| pubmed:22020111 | path(MESH:Atherosclerosis) increases g(HGNC:SCARB1) |
| pubmed:22020111 | path(MESH:Atherosclerosis) increases g(HGNC:TUBB3) |
| pubmed:22020111 | path(MESH:Atherosclerosis) decreases g(HGNC:NR3C1) |
| pubmed:22020111 | path(MESH:Atherosclerosis) decreases g(HGNC:PPARA) |
| pubmed:22020111 | path(MESH:Atherosclerosis) increases g(HGNC:EGR1) |
| pubmed:22020111 | path(MESH:Atherosclerosis) increases g(HGNC:PTGS2) |
| pubmed:22020111 | path(MESH:Atherosclerosis) increases g(HGNC:SOAT1) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:ACLY) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:ANTXR1) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:C20orf27) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:CCNA2) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:CHAF1A) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:DHFR) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:EFCAB11) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:FEN1) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:GINS2) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:MCM10) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:MCM4) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:RNASEH2A) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:SLIT2) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:SPC25) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:TFRC) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:TK1) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:TMEM97) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:TRIP13) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:TUBB) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:TUBB3) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:TYMS) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:UBA1) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:UNG) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:VRK1) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") decreases g(HGNC:ABCD3) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:GLRX2) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") positiveCorrelation g(HGNC:GLRX2) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:MICB) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") increases g(HGNC:NQO1) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") positiveCorrelation g(HGNC:NQO1) |
| pubmed:22020111 | path(MESH:"Colorectal Neoplasms") positiveCorrelation bp(MESH:"Oxidative Stress") |
| pubmed:22020111 | g(HGNC:GLRX2) positiveCorrelation path(MESH:"Colorectal Neoplasms") |
| pubmed:22020111 | g(HGNC:NQO1) positiveCorrelation path(MESH:"Colorectal Neoplasms") |
| pubmed:22020111 | g(HGNC:NQO1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22020111 | g(HGNC:GLRX) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22020111 | g(HGNC:SOD1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27181519 | g(HGNC:SOD1) association path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:22020111 | path(MESH:"Kidney Diseases") negativeCorrelation act(p(HGNC:NFE2L2)) |
| pubmed:30740335 | path(MESH:"Kidney Diseases") association path(MESH:"Endoplasmic Reticulum Stress") |
| pubmed:30688256 | a(MESH:"Autophagy-Related Proteins", loc(GO:"phagophore assembly site")) increases a(GO:phagophore) |
| pubmed:21722302 | a(GO:phagophore) increases a(MESH:Autophagosomes) |
| pubmed:18930136 | a(GO:phagophore) increases a(GO:autophagosome) |
| pubmed:30688256 | p(MGI:Atg5) decreases path(HP:Neurodegeneration) |
| pubmed:25784053 | p(MGI:Atg5) decreases path(HP:Neurodegeneration) |
| pubmed:30688256 | p(MGI:Atg7) decreases path(HP:Neurodegeneration) |
| pubmed:25784053 | p(MGI:Atg7) decreases path(HP:Neurodegeneration) |
| pubmed:24027553 | p(MGI:Atg7) decreases path(CONSO:Neurodegeneration) |
| pubmed:24027553 | p(MGI:Atg7) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24027553 | p(MGI:Atg7) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 214), pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) |
| pubmed:24027553 | p(MGI:Atg7) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:24027553 | p(MGI:Atg7) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:30688256 | p(HGNC:BNIP3L) positiveCorrelation bp(GO:"erythrocyte maturation") |
| pubmed:30688256 | bp(GO:"erythrocyte maturation") positiveCorrelation p(HGNC:BNIP3L) |
| pubmed:30688256 | complex(p(HGNC:BNIP3L), p(HGNC:GABARAPL2)) increases a(GO:phagophore) |
| pubmed:18930136 | p(HGNC:GABARAPL2) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:GABARAPL2)) |
| pubmed:30688256 | complex(p(HGNC:BNIP3L), p(HGNC:MAP1LC3B)) increases a(GO:phagophore) |
| pubmed:18930136 | p(HGNC:MAP1LC3B) increases complex(a(GO:autophagosome), p(HGNC:MAP1LC3B)) |
| pubmed:18930136 | p(HGNC:MAP1LC3B) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) |
| pubmed:27260836 | p(HGNC:MAP1LC3B) negativeCorrelation p(HGNC:PICALM) |
| pubmed:30688256 | path(HBP:"mitochondrial dysfunction") increases bp(GO:"cell death") |
| pubmed:30688256 | path(HBP:"mitochondrial dysfunction") increases bp(GO:"calcium-mediated signaling") |
| pubmed:30688256 | path(HBP:"mitochondrial dysfunction") increases a(CHEBI:"reactive oxygen species") |
| pubmed:30688256 | path(HBP:"mitochondrial dysfunction") increases path(MESH:Apoptosis) |
| pubmed:30688256 | complex(p(HGNC:PMPCA), p(HGNC:PMPCB)) directlyIncreases deg(p(HGNC:PINK1)) |
| pubmed:30688256 | p(HGNCGENEFAMILY:"Miro like atypical Rho GTPases") increases bp(GO:"axonal transport of mitochondrion") |
| pubmed:30688256 | p(HGNCGENEFAMILY:"Miro like atypical Rho GTPases") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:30688256 | p(HGNCGENEFAMILY:"Miro like atypical Rho GTPases") decreases act(p(HGNC:MARK1)) |
| pubmed:30688256 | p(HGNCGENEFAMILY:"Miro like atypical Rho GTPases") decreases path(HP:Neurodegeneration) |
| pubmed:30688256 | act(p(HGNCGENEFAMILY:"Miro like atypical Rho GTPases")) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30688256 | p(HGNC:PINK1, var("?")) increases path(MESH:"Parkinson Disease") |
| pubmed:30116051 | p(HGNC:PINK1, var("?")) association path(MESH:"Parkinson Disease") |
| pubmed:30688256 | p(HGNC:PINK1, var("?")) decreases bp(GO:mitophagy) |
| pubmed:30116051 | p(HGNC:PINK1, var("?")) decreases bp(GO:mitophagy) |
| pubmed:30688256 | p(HGNC:PINK1, var("?")) increases path(HBP:"mitochondrial dysfunction") |
| pubmed:21722302 | p(HGNC:PINK1, var("?")) increases path(DOID:"autosomal recessive Parkinson's disease 14") |
| pubmed:21722302 | p(HGNC:PINK1, var("?")) association bp(MESH:"Protein Stability") |
| pubmed:30688256 | p(HGNC:DNM1L, var("?")) increases path(HP:Neurodegeneration) |
| pubmed:30688256 | p(HGNC:CCND1) decreases a(HBP:"amyloid-beta aggregates", loc(MESH:"Extracellular Space")) |
| pubmed:30688256 | p(HGNC:CCND1) decreases path(HP:Neurodegeneration) |
| pubmed:30688256 | a(CHEBI:FAD) association bp(GO:autophagy) |
| pubmed:30688256 | complex(p(HGNC:LRRK2), p(HGNC:RHOT1)) increases deg(p(HGNC:RHOT1)) |
| pubmed:30688256 | p(HGNC:RHOT1) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30688256 | deg(p(HGNC:RHOT1)) decreases bp(GO:"axonal transport of mitochondrion") |
| pubmed:30688256 | p(HGNC:RHOT1) decreases path(HP:Neurodegeneration) |
| pubmed:30688256 | a(HBP:"alpha-synuclein aggregates") increases a(CHEBI:"reactive oxygen species") |
| pubmed:30688256 | a(HBP:"huntingtin aggregates") increases bp(GO:autophagy) |
| pubmed:30688256 | a(HBP:"huntingtin aggregates") increases p(HGNC:ATG7, var("?")) |
| pubmed:30688256 | p(HGNC:ATG7, var("?")) increases path(MESH:"Huntington Disease") |
| pubmed:29758300 | p(HGNC:ATG7) increases bp(GO:macroautophagy) |
| pubmed:18930136 | p(HGNC:ATG7) decreases path(CONSO:Neurodegeneration) |
| pubmed:30688256 | a(PUBCHEM:124886) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30688256 | a(PUBCHEM:124886) increases act(a(MESH:Neurons)) |
| pubmed:30688256 | a(PUBCHEM:124886) decreases path(MESH:"Mitochondrial Diseases") |
| pubmed:30688256 | bp(GO:"cell redox homeostasis") decreases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30740335 | bp(GO:"cell redox homeostasis") decreases path(MESH:"Protein Unfolding") |
| pubmed:31413141 | p(HGNC:TREM2, frag("?")) positiveCorrelation bp(GO:aging) |
| pubmed:31413141 | p(HGNC:TREM2, frag("?")) positiveCorrelation p(HGNC:MAPT) |
| pubmed:31413141 | p(HGNC:TREM2, frag("?")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:31413141 | p(HGNC:TREM2, frag("?")) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:31413141 | p(HGNC:TREM2, frag("?")) positiveCorrelation r(DBSNP:rs1582763) |
| pubmed:31413141 | p(HGNC:TREM2, frag("?")) association r(DBSNP:rs1582763) |
| pubmed:31413141 | p(HGNC:TREM2, frag("?")) association r(DBSNP:rs6591561) |
| pubmed:31413141 | p(HGNC:TREM2, var("p.Lys211Pro")) decreases p(HGNC:TREM2, frag("?")) |
| pubmed:31413141 | p(HGNC:TREM2, var("p.Asp87Asn")) decreases p(HGNC:TREM2, frag("?")) |
| pubmed:31413141 | r(DBSNP:rs1582763) positiveCorrelation p(HGNC:TREM2, frag("?")) |
| pubmed:31413141 | r(DBSNP:rs1582763) association p(HGNC:TREM2, frag("?")) |
| pubmed:31413141 | r(DBSNP:rs1582763) decreases p(HGNC:MS4A6A) |
| pubmed:31413141 | r(DBSNP:rs1582763) decreases p(HGNC:MS4A4A) |
| pubmed:31413141 | r(DBSNP:rs1582763) increases p(HGNC:MS4A2) |
| pubmed:31413141 | r(DBSNP:rs6591561) association p(HGNC:TREM2, frag("?")) |
| pubmed:31413141 | r(DBSNP:rs769449) association p(HGNC:APOE) |
| pubmed:31413141 | r(DBSNP:rs769449) causesNoChange p(HGNC:TREM2, frag("?")) |
| pubmed:31413141 | p(HGNC:MS4A4A, loc(GO:"plasma membrane")) association bp(GO:"protein transport") |
| pubmed:31413141 | p(HGNC:MS4A4A, loc(GO:cytoplasm)) association bp(GO:"protein transport") |
| pubmed:31413141 | r(HGNC:MS4A6A) positiveCorrelation r(HGNC:TREM2) |
| pubmed:31413141 | r(HGNC:TREM2) positiveCorrelation r(HGNC:MS4A6A) |
| pubmed:31413141 | r(HGNC:TREM2) positiveCorrelation r(HGNC:MS4A4A) |
| pubmed:31413141 | r(HGNC:TREM2) positiveCorrelation r(HGNC:MS4A7) |
| pubmed:31413141 | r(HGNC:MS4A4A) positiveCorrelation r(HGNC:TREM2) |
| pubmed:31413141 | r(HGNC:MS4A7) positiveCorrelation r(HGNC:TREM2) |
| pubmed:31413141 | complex(complex(GO:"immunoglobulin complex"), p(HGNC:MS4A4A)) decreases p(HGNC:TREM2, frag("?"), loc(MESH:Macrophages)) |
| pubmed:23454242 | bp(GO:phosphorylation) regulates bp(GO:"cell division") |
| pubmed:23454242 | bp(GO:phosphorylation) regulates bp(GO:"cell growth") |
| pubmed:23454242 | bp(GO:phosphorylation) regulates bp(GO:"cell development") |
| pubmed:23454242 | bp(GO:phosphorylation) increases bp(GO:"negative regulation of apoptotic process") |
| pubmed:23454242 | bp(GO:phosphorylation) regulates bp(GO:"cell population proliferation") |
| pubmed:23454242 | bp(GO:phosphorylation) regulates bp(GO:"apoptotic process") |
| pubmed:21882945 | bp(GO:phosphorylation) regulates a(CONSO:"Hsp27 oligomers") |
| pubmed:25784053 | bp(GO:"cell division") association p(FPLX:"CCT_complex") |
| pubmed:18305152 | bp(GO:"cell division") increases bp(GO:"cell cycle G1/S phase transition") |
| pubmed:23454242 | p(FPLX:PPP2) regulates bp(GO:"glycolytic process") |
| pubmed:23454242 | p(FPLX:PPP2) regulates bp(GO:"lipid metabolic process") |
| pubmed:23454242 | p(FPLX:PPP2) regulates bp(GO:"catecholamine biosynthetic process") |
| pubmed:23454242 | p(FPLX:PPP2) regulates bp(GO:"cell cycle") |
| pubmed:23454242 | p(FPLX:PPP2) regulates bp(GO:"DNA replication") |
| pubmed:23454242 | p(FPLX:PPP2) regulates bp(GO:"transcription, DNA-templated") |
| pubmed:23454242 | p(FPLX:PPP2) regulates bp(GO:translation) |
| pubmed:23454242 | p(FPLX:PPP2) regulates bp(GO:"signal transduction") |
| pubmed:23454242 | p(FPLX:PPP2) regulates bp(GO:"cell population proliferation") |
| pubmed:23454242 | p(FPLX:PPP2) regulates bp(GO:"cell population proliferation") |
| pubmed:23454242 | p(FPLX:PPP2) regulates bp(GO:"cytoskeleton organization") |
| pubmed:23454242 | p(FPLX:PPP2) increases bp(GO:"cytoskeleton organization") |
| pubmed:23454242 | p(FPLX:PPP2) regulates bp(GO:"cell motility") |
| pubmed:23454242 | p(FPLX:PPP2) regulates bp(GO:"apoptotic process") |
| pubmed:23454242 | p(FPLX:PPP2) regulates bp(GO:"apoptotic process") |
| pubmed:23454242 | p(FPLX:PPP2) association path(MESH:"Cell Transformation, Neoplastic") |
| pubmed:23454242 | p(FPLX:PPP2) association path(MESH:Neoplasms) |
| pubmed:23454242 | p(FPLX:PPP2) decreases path(MESH:Neoplasms) |
| pubmed:23454242 | act(p(FPLX:PPP2)) negativeCorrelation path(MESH:Neoplasms) |
| pubmed:22299660 | p(FPLX:PPP2) association path(MESH:Neoplasms) |
| pubmed:23454242 | p(FPLX:PPP2) decreases p(HGNC:VIM, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23454242 | act(p(FPLX:PPP2)) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:22299660 | act(p(FPLX:PPP2)) negativeCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:23454242 | act(p(FPLX:PPP2)) association p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) |
| pubmed:23454242 | act(p(FPLX:PPP2)) association p(FPLX:PPP2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23454242 | p(FPLX:PPP2) regulates p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation", Thr, 308)) |
| pubmed:23454242 | p(FPLX:PPP2) association bp(GO:"Wnt signaling pathway") |
| pubmed:23454242 | p(FPLX:PPP2) decreases p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23454242 | p(FPLX:PPP2) increases deg(p(HGNC:CTNNB1)) |
| pubmed:23454242 | p(FPLX:PPP2) decreases p(HGNC:BAD, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23454242 | p(FPLX:PPP2) decreases p(HGNC:BCL2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:12428809 | p(FPLX:PPP2) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22299660 | p(FPLX:PPP2) association a(MESH:Cytosol) |
| pubmed:22299660 | p(FPLX:PPP2) association a(MESH:"Cell Nucleus") |
| pubmed:22299660 | p(FPLX:PPP2) association a(MESH:Mitochondria) |
| pubmed:22299660 | p(FPLX:PPP2) association a(MESH:Cytoskeleton) |
| pubmed:22299660 | p(FPLX:PPP2) association a(MESH:"Cell Membrane") |
| pubmed:22299660 | p(FPLX:PPP2) association path(MESH:"Frontotemporal Dementia") |
| pubmed:22299660 | act(p(FPLX:PPP2)) negativeCorrelation a(CONSO:"paired helical filaments") |
| pubmed:22299660 | act(p(FPLX:PPP2)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:22299660 | act(p(FPLX:PPP2)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 42)) |
| pubmed:22299660 | act(p(FPLX:PPP2)) decreases act(p(HGNC:CDK5)) |
| pubmed:22299660 | act(p(FPLX:PPP2)) decreases act(p(HGNC:TPK1)) |
| pubmed:22299660 | act(p(FPLX:PPP2)) decreases act(p(HGNC:GSK3B)) |
| pubmed:22299660 | act(p(FPLX:PPP2)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22299660 | act(p(FPLX:PPP2)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22299660 | p(FPLX:PPP2) negativeCorrelation path(MESH:"Down Syndrome") |
| pubmed:23943618 | act(p(FPLX:PPP2)) positiveCorrelation complex(p(FPLX:PPP2), p(HGNC:MAPT)) |
| pubmed:27068745 | act(p(FPLX:PPP2), ma(go:0016791 ! "phosphatase activity")) positiveCorrelation p(HGNC:UNC5B) |
| pubmed:27068745 | act(p(FPLX:PPP2), ma(go:0016791 ! "phosphatase activity")) decreases act(p(HGNC:DAPK1, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:23454242 | path(MESH:"Cell Transformation, Neoplastic") association p(FPLX:PPP2) |
| pubmed:22299660 | p(FPLX:PPP2C) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23454242 | p(HGNC:PPP2CB) association a(MESH:Cytosol) |
| pubmed:23454242 | p(HGNC:PPP2CB) association a(MESH:"Cell Nucleus") |
| pubmed:24653673 | p(HGNC:PPP2CB) association act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | deg(p(HGNC:PPP2CB)) positiveCorrelation p(HGNC:IGBP1, frag("?")) |
| pubmed:24653673 | p(HGNC:PPP2CB) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23454242 | a(MESH:"Cell Membrane") association p(HGNC:PPP2CA) |
| pubmed:22299660 | a(MESH:"Cell Membrane") association p(FPLX:PPP2) |
| pubmed:23454242 | a(MESH:Cytosol) association p(HGNC:PPP2CB) |
| pubmed:23454242 | a(MESH:Cytosol) association p(HGNC:PPP2R2A) |
| pubmed:23454242 | a(MESH:Cytosol) association p(HGNC:PPP2R2B) |
| pubmed:23454242 | a(MESH:Cytosol) association p(HGNC:PPP2R5A) |
| pubmed:23454242 | a(MESH:Cytosol) association p(HGNC:PPP2R5B) |
| pubmed:23454242 | a(MESH:Cytosol) association p(HGNC:PPP2R5E) |
| pubmed:23454242 | a(MESH:Cytosol) association p(HGNC:PPP2R5D) |
| pubmed:22299660 | a(MESH:Cytosol) association p(FPLX:PPP2) |
| pubmed:23454242 | a(MESH:"Cell Nucleus") association p(HGNC:PPP2CB) |
| pubmed:23454242 | a(MESH:"Cell Nucleus") association p(HGNC:PPP2R5C) |
| pubmed:23454242 | a(MESH:"Cell Nucleus") association p(HGNC:PPP2R5D) |
| pubmed:22299660 | a(MESH:"Cell Nucleus") association p(FPLX:PPP2) |
| pubmed:19277525 | p(HGNC:PPP2R1A) association p(INTERPRO:"HEAT repeat") |
| pubmed:19277525 | p(HGNC:PPP2R1A) association p(HGNC:PPP2CA) |
| pubmed:19277525 | act(p(HGNC:PPP2R1A)) increases act(p(HGNC:PPP2CA)) |
| pubmed:19277525 | act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) |
| pubmed:19277525 | act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pubmed:19277525 | act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) |
| pubmed:19277525 | act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) |
| pubmed:19277525 | act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) |
| pubmed:19277525 | act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:STRN3)) |
| pubmed:19277525 | act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:STRN)) |
| pubmed:19933700 | p(HGNC:PPP2R1A) association bp(GO:"cell-cell signaling") |
| pubmed:19933700 | p(HGNC:PPP2R1A) association path(MESH:Metabolism) |
| pubmed:23454242 | p(HGNC:PPP2R2A) association a(MESH:Cytosol) |
| pubmed:23454242 | p(HGNC:PPP2R2A) increases bp(GO:cytokinesis) |
| pubmed:23454242 | p(HGNC:PPP2R2A) association bp(GO:"cytoskeleton organization") |
| pubmed:24653673 | p(HGNC:PPP2R2A) increases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:PPP2R2A) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | p(HGNC:PPP2R2A) increases complex(a(GO:"protein phosphatase type 2A complex"), a(GO:microtubule)) |
| pubmed:24653673 | p(HGNC:PPP2R2A) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22299660 | p(HGNC:PPP2R2A) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22299660 | p(HGNC:PPP2R2A) association a(MESH:Brain) |
| pubmed:23454242 | p(HGNC:PPP2R2C) association a(MESH:Cytoskeleton) |
| pubmed:23454242 | p(HGNC:PPP2R2C) increases bp(GO:cytokinesis) |
| pubmed:23454242 | p(HGNC:PPP2R2C) association bp(GO:"cytoskeleton organization") |
| pubmed:19277525 | p(HGNC:PPP2R3A) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) |
| pubmed:19277525 | p(HGNC:PPP2R3A) directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) |
| pubmed:19277525 | p(HGNC:PPP2R3A) association complex(a(PUBCHEM:5460341), p(INTERPRO:"EF-hand domain")) |
| pubmed:19277525 | p(HGNC:PPP2R3B) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) |
| pubmed:19277525 | p(HGNC:PPP2R3B) directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) |
| pubmed:19277525 | p(HGNC:PTPA) increases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:PTPA) increases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:19277525 | p(HGNC:PTPA) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) |
| pubmed:19277525 | p(HGNC:PTPA) increases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) |
| pubmed:24653673 | p(HGNC:PTPA) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | p(HGNC:PTPA) decreases p(FPLX:PPP2, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) |
| pubmed:23454242 | p(HGNC:PPP2R5A) association a(MESH:Cytosol) |
| pubmed:23454242 | p(HGNC:PPP2R5C) association a(MESH:"Cell Nucleus") |
| pubmed:23454242 | p(HGNC:PPP2R5D) association a(MESH:Cytosol) |
| pubmed:23454242 | p(HGNC:PPP2R5D) association a(MESH:"Cell Nucleus") |
| pubmed:24653673 | p(HGNC:PPP2R5D) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23454242 | p(HGNC:PPP2R5E) association a(MESH:Cytosol) |
| pubmed:23454242 | composite(a(CHEBI:"magnesium(2+)"), a(CHEBI:ATP)) increases act(p(HGNC:PPP2R3A)) |
| pubmed:24027553 | composite(a(CHEBI:"magnesium(2+)"), a(CHEBI:ATP)) increases act(p(HGNCGENEFAMILY:Proteasome)) |
| pubmed:23454242 | complex(p(FPLX:PPP2), p(HGNC:SGO1)) decreases p(FPLX:Cohesin, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23454242 | p(FPLX:Cohesin, pmod(go:0006468 ! "protein phosphorylation")) increases bp(GO:"spindle disassembly") |
| pubmed:23454242 | p(HGNC:SET) decreases act(p(FPLX:PPP2)) |
| pubmed:23454242 | p(HGNC:SET) decreases act(p(FPLX:PPP2)) |
| pubmed:22299660 | p(HGNC:SET) decreases act(p(FPLX:PPP2)) |
| pubmed:24653673 | p(HGNC:SET) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:SET) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:SET) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:SET) increases complex(p(HGNC:PPP2CA), p(HGNC:SET)) |
| pubmed:24653673 | p(HGNC:SET) increases complex(p(HGNC:PPP2CB), p(HGNC:SET)) |
| pubmed:24653673 | p(HGNC:SET) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22299660 | p(HGNC:SET) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23454242 | a(PUBCHEM:5311365) decreases act(p(FPLX:PPP2)) |
| pubmed:24653673 | a(PUBCHEM:5311365) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | a(PUBCHEM:5311365) increases complex(a(PUBCHEM:5311365), p(HGNC:PPP2CA)) |
| pubmed:24653673 | a(PUBCHEM:5311365) increases complex(a(PUBCHEM:5311365), p(HGNC:PPP2CB)) |
| pubmed:23454242 | a(CHEBI:microcystin) decreases act(p(FPLX:PPP2)) |
| pubmed:23454242 | a(CHEBI:cantharidin) decreases act(p(FPLX:PPP2)) |
| pubmed:23454242 | a(PUBCHEM:4162) decreases act(p(FPLX:PPP2)) |
| pubmed:23454242 | a(PUBCHEM:6913994) decreases act(p(FPLX:PPP2)) |
| pubmed:24653673 | a(PUBCHEM:6913994) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | a(PUBCHEM:6913994) increases complex(a(PUBCHEM:6913994), p(HGNC:PPP2CA)) |
| pubmed:24653673 | a(PUBCHEM:6913994) increases complex(a(PUBCHEM:6913994), p(HGNC:PPP2CB)) |
| pubmed:23454242 | a(CHEBI:Tautomycin) decreases act(p(FPLX:PPP2)) |
| pubmed:23454242 | a(PUBCHEM:71361092) increases path(MESH:Neoplasms) |
| pubmed:23454242 | a(PUBCHEM:71361092) decreases act(p(FPLX:PPP2)) |
| pubmed:23454242 | p(HGNC:CIP2A) increases composite(p(HGNC:CIP2A), p(HGNC:MYC)) |
| pubmed:23454242 | p(HGNC:CIP2A) decreases act(p(FPLX:PPP2C)) |
| pubmed:23454242 | composite(p(HGNC:CIP2A), p(HGNC:MYC)) decreases deg(p(HGNC:MYC)) |
| pubmed:23454242 | a(CHEBI:bortezomib) decreases p(HGNC:CIP2A) |
| pubmed:23454242 | a(CHEBI:bortezomib) decreases r(HGNC:CIP2A) |
| pubmed:23454242 | a(CHEBI:bortezomib) increases act(p(FPLX:PPP2C)) |
| pubmed:23454242 | p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) association act(p(FPLX:PPP2)) |
| pubmed:19277525 | p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) regulates bp(GO:"cell cycle") |
| pubmed:24653673 | p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) positiveCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pubmed:24653673 | p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) association complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pubmed:24653673 | p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) positiveCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pubmed:24653673 | p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) association complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pubmed:24653673 | p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) association bp(GO:"one-carbon metabolic process") |
| pubmed:24653673 | p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) negativeCorrelation a(CHEBI:homocysteine) |
| pubmed:24653673 | p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) negativeCorrelation p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) regulates bp(CONSO:"APP processing") |
| pubmed:24653673 | p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) regulates bp(MESH:"Neuronal Outgrowth") |
| pubmed:24653673 | p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) regulates p(HGNC:MAPT) |
| pubmed:23454242 | p(FPLX:PPP2, pmod(go:0006468 ! "protein phosphorylation")) association act(p(FPLX:PPP2)) |
| pubmed:23454242 | p(FPLX:PPP2, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) decreases act(p(FPLX:PPP2)) |
| pubmed:23454242 | p(FPLX:PPP2, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) decreases complex(p(HGNC:PPP2R2A), p(HGNC:PPP2R5B)) |
| pubmed:24653673 | p(FPLX:PPP2, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(FPLX:PPP2, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:23454242 | p(HGNC:LCMT1) increases p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation", Leu, 309)) |
| pubmed:19277525 | p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) |
| pubmed:19277525 | p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) |
| pubmed:24653673 | p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) |
| pubmed:24653673 | p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) |
| pubmed:24653673 | p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) |
| pubmed:24653673 | p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) |
| pubmed:23943618 | p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) |
| pubmed:29281045 | p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) |
| pubmed:19277525 | act(p(HGNC:LCMT1)) negativeCorrelation act(p(HGNC:PPME1)) |
| pubmed:19277525 | p(HGNC:LCMT1) causesNoChange act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(go:0006479 ! "protein methylation", Leu, 309)) |
| pubmed:24653673 | p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(go:0006479 ! "protein methylation", Leu, 309)) |
| pubmed:24653673 | p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(go:0006479 ! "protein methylation", Leu, 309)) |
| pubmed:24653673 | p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(go:0006479 ! "protein methylation", Leu, 309)) |
| pubmed:24653673 | p(HGNC:LCMT1) regulates complex(a(GO:"protein phosphatase type 2A complex"), a(MESH:"Membrane Microdomains")) |
| pubmed:24653673 | p(HGNC:LCMT1) increases p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) |
| pubmed:23454242 | p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation", Leu, 309)) increases act(p(FPLX:PPP2)) |
| pubmed:23454242 | p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation", Thr, 308)) increases act(p(FPLX:AKT)) |
| pubmed:23454242 | p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation")) increases bp(GO:"Wnt signaling pathway") |
| pubmed:23454242 | p(HGNC:BAD, pmod(go:0006468 ! "protein phosphorylation")) decreases bp(GO:"apoptotic process") |
| pubmed:23454242 | p(HGNC:BCL2, pmod(go:0006468 ! "protein phosphorylation")) decreases bp(GO:"apoptotic process") |
| pubmed:21722302 | p(HGNC:BCL2, pmod(go:0006468 ! "protein phosphorylation")) decreases composite(a(MESH:Beclin-1), p(HGNC:BCL2)) |
| pubmed:23528736 | p(HGNC:BCL2, pmod(go:0006468 ! "protein phosphorylation")) increases bp(GO:autophagy) |
| pubmed:19277525 | complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell cycle") |
| pubmed:19277525 | complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell population proliferation") |
| pubmed:19277525 | complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell death") |
| pubmed:19277525 | complex(GO:"protein phosphatase type 2A complex") regulates act(a(GO:cytoskeleton)) |
| pubmed:19277525 | complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell motility") |
| pubmed:19277525 | complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"signal transduction") |
| pubmed:19277525 | complex(GO:"protein phosphatase type 2A complex") increases bp(GO:"protein dephosphorylation") |
| pubmed:19277525 | complex(GO:"protein phosphatase type 2A complex") decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:19277525 | act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation composite(p(HGNC:PPME1), p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) |
| pubmed:24653673 | complex(GO:"protein phosphatase type 2A complex") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:GSK3B)) |
| pubmed:24653673 | complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:CDK5)) |
| pubmed:24653673 | complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), a(MESH:"Receptors, N-Methyl-D-Aspartate")) |
| pubmed:24653673 | complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:GRM5)) |
| pubmed:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:PPME1) |
| pubmed:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | complex(GO:"protein phosphatase type 2A complex") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) association p(HGNC:PPP2CA) |
| pubmed:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) association p(HGNC:PPP2CB) |
| pubmed:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:ANP32A) |
| pubmed:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:SET) |
| pubmed:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:SET) |
| pubmed:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:SET, frag("?")) |
| pubmed:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(FPLX:PPP2, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) |
| pubmed:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) decreases bp(GO:"neuron death") |
| pubmed:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(HGNC:GSK3B)) |
| pubmed:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(HGNC:CDK5)) |
| pubmed:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(FPLX:ERK)) |
| pubmed:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(FPLX:JNK)) |
| pubmed:10464280 | act(complex(GO:"protein phosphatase type 2A complex")) increases complex(complex(GO:"protein phosphatase type 2A complex"), p(CONSO:"microtubule-binding region")) |
| pubmed:10464280 | act(complex(GO:"protein phosphatase type 2A complex")) increases rxn(reactants(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) |
| pubmed:19277525 | p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pubmed:19277525 | p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pubmed:19277525 | p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pubmed:19277525 | p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") association p(INTERPRO:"WD40 repeat") |
| pubmed:19277525 | p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases bp(GO:"protein dephosphorylation") |
| pubmed:19277525 | p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2CA), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pubmed:19277525 | p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pubmed:19277525 | p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:19277525 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19277525 | p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) |
| pubmed:19277525 | p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) |
| pubmed:19277525 | p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") association p(INTERPRO:"HEAT repeat") |
| pubmed:19277525 | p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") regulates complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) |
| pubmed:19277525 | p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") causesNoChange complex(p(HGNC:PPP2CA), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) |
| pubmed:19277525 | p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases complex(p(HGNC:PPP2CA), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) |
| pubmed:24653673 | p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases tloc(complex(GO:"protein phosphatase type 2A complex"), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:24653673 | p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases tloc(complex(GO:"protein phosphatase type 2A complex"), fromLoc(GO:cytoplasm), toLoc(GO:centrosome)) |
| pubmed:19277525 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:SGO1), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) |
| pubmed:19277525 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19277525 | p(HGNC:STRN3) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN3)) |
| pubmed:19277525 | p(HGNC:STRN) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN)) |
| pubmed:19277525 | p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) decreases complex(p(HGNC:IGBP1), p(HGNC:PPP2CA)) |
| pubmed:19277525 | p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) increases act(p(HGNC:PPP2CA)) |
| pubmed:24653673 | p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) increases complex(GO:"protein phosphatase type 2A complex") |
| pubmed:24653673 | p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) increases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2CB), p(HGNC:PPP2R2A)) |
| pubmed:23943618 | p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) increases act(p(FPLX:PPP2)) |
| pubmed:19277525 | complex(p(HGNC:IGBP1), p(HGNC:PPP2CA)) decreases bp(GO:"cell death") |
| pubmed:24653673 | complex(p(HGNC:IGBP1), p(HGNC:PPP2CA)) regulates complex(GO:"protein phosphatase type 2A complex") |
| pubmed:19277525 | p(HGNC:PPME1) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) |
| pubmed:19277525 | p(HGNC:PPME1) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) |
| pubmed:19277525 | p(HGNC:PPME1) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) |
| pubmed:24653673 | act(p(HGNC:PPME1)) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) |
| pubmed:29281045 | p(HGNC:PPME1) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) |
| pubmed:19277525 | act(p(HGNC:PPME1)) negativeCorrelation act(p(HGNC:LCMT1)) |
| pubmed:19277525 | p(HGNC:PPME1) increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) |
| pubmed:19277525 | p(HGNC:PPME1) directlyIncreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) |
| pubmed:19277525 | p(HGNC:PPME1) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:PPME1) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:PPME1) increases complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) |
| pubmed:24653673 | p(HGNC:PPME1) increases complex(p(HGNC:PPME1), p(HGNC:PPP2CB)) |
| pubmed:22299660 | p(HGNC:PPME1) decreases p(FPLX:PPP2C, pmod(go:0006479 ! "protein methylation")) |
| pubmed:19277525 | p(INTERPRO:"HEAT repeat") association p(HGNC:PPP2R1A) |
| pubmed:19277525 | p(INTERPRO:"HEAT repeat") association p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") |
| pubmed:30027901 | p(INTERPRO:"HEAT repeat") regulates a(MESH:"Nucleocytoplasmic Transport Proteins") |
| pubmed:30027901 | p(INTERPRO:"HEAT repeat") regulates a(GO:"cytoplasmic microtubule") |
| pubmed:30027901 | p(INTERPRO:"HEAT repeat") regulates bp(GO:"chromosome segregation") |
| pubmed:19277525 | p(UNIPROT:P03081) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(UNIPROT:P03081)) |
| pubmed:19277525 | p(UNIPROT:P03081) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) |
| pubmed:19277525 | p(UNIPROT:P03081) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) |
| pubmed:19277525 | p(UNIPROT:P03081) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) |
| pubmed:19277525 | p(UNIPROT:P03081) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN3)) |
| pubmed:19277525 | p(UNIPROT:P03081) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN)) |
| pubmed:19277525 | complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) association p(HGNC:PPP2CA) |
| pubmed:19277525 | complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) association complex(p(HGNC:PPP2R1A), p(INTERPRO:"HEAT repeat")) |
| pubmed:19277525 | complex(p(HGNC:PPP2R1A), p(INTERPRO:"HEAT repeat")) association complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) |
| pubmed:19277525 | p(INTERPRO:"HEAT repeat", var("p.Arg418Trp")) decreases complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) |
| pubmed:19277525 | p(INTERPRO:"HEAT repeat", var("p.Val545Ala")) decreases complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) |
| pubmed:19277525 | a(CHEBI:microcystin-LR) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:19277525 | a(CHEBI:microcystin-LR) increases path(MESH:Neoplasms) |
| pubmed:19277525 | a(CHEBI:microcystin-LR) decreases act(p(HGNC:PPME1)) |
| pubmed:29228318 | a(CHEBI:microcystin-LR) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")) |
| pubmed:19277525 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:SGO1), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) increases bp(GO:"cell cycle") |
| pubmed:19277525 | p(INTERPRO:"WD40 repeat") association p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") |
| pubmed:19277525 | complex(a(PUBCHEM:5460341), p(INTERPRO:"EF-hand domain")) association p(HGNC:PPP2R3A) |
| pubmed:19277525 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:19277525 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pubmed:19277525 | p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")) increases complex(GO:"protein phosphatase type 2A complex") |
| pubmed:24653673 | p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")) increases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:19277525 | p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pubmed:19277525 | p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) |
| pubmed:29228318 | p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")) decreases act(p(HGNC:PPP2CA)) |
| pubmed:29228318 | p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2CB)) |
| pubmed:19277525 | p(HGNC:PPP2CA, var("?")) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pubmed:19277525 | p(HGNC:PPP2CA, var("?")) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) |
| pubmed:19277525 | p(HGNC:PPP2CA, var("p.Arg295_Leu309del")) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pubmed:19277525 | p(HGNC:PPP2CA, var("p.Arg295_Leu309del")) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) |
| pubmed:19277525 | complex(p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")), p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pubmed:19277525 | complex(p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")), p(HGNC:PPP2R1A)) increases complex(GO:"protein phosphatase type 2A complex") |
| pubmed:19277525 | complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases act(p(HGNC:PPP2CA)) |
| pubmed:19277525 | complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases act(p(HGNC:PPP2CA)) |
| pubmed:19277525 | complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) increases act(p(HGNC:PPME1)) |
| pubmed:19277525 | complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) increases act(p(HGNC:PPME1)) |
| pubmed:19277525 | complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) increases act(p(HGNC:PPME1)) |
| pubmed:19277525 | complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) |
| pubmed:19277525 | complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) |
| pubmed:19277525 | composite(p(HGNC:PPME1), p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:PPP2CB, pmod(go:0006479 ! "protein methylation", Leu, 309)) increases complex(GO:"protein phosphatase type 2A complex") |
| pubmed:24653673 | p(HGNC:PPP2CB, pmod(go:0006479 ! "protein methylation", Leu, 309)) increases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:PPP2CB, pmod(go:0006479 ! "protein methylation", Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2CB), p(HGNC:PPP2R2A)) |
| pubmed:24653673 | a(CHEBI:S-adenosyl-L-methionine) increases act(p(HGNC:LCMT1)) |
| pubmed:24653673 | a(CHEBI:S-adenosyl-L-homocysteine) decreases act(p(HGNC:LCMT1)) |
| pubmed:24653673 | complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")) |
| pubmed:24653673 | complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) regulates complex(GO:"protein phosphatase type 2A complex") |
| pubmed:24653673 | complex(p(HGNC:PPME1), p(HGNC:PPP2CB)) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")) |
| pubmed:24653673 | complex(p(HGNC:PPME1), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | complex(p(HGNC:PPME1), p(HGNC:PPP2CB)) regulates complex(GO:"protein phosphatase type 2A complex") |
| pubmed:24653673 | p(HGNC:PPP2CB, pmod(go:0006479 ! "protein methylation")) increases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:PPP2CA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:PPP2CA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:PPP2CA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | p(HGNC:PPP2CB, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:PPP2CB, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:PPP2CB, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | p(HGNC:PPP2CA, pmod(go:0016567 ! "protein ubiquitination")) increases deg(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:PPP2CA, pmod(CONSO:nitration, Tyr)) increases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:PPP2R5A, pmod(go:0006468 ! "protein phosphorylation", Ser)) regulates act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:PPP2R5D, pmod(go:0006468 ! "protein phosphorylation", Ser)) regulates act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:PPP2R1A, pmod(go:0006468 ! "protein phosphorylation", Ser), pmod(go:0006468 ! "protein phosphorylation", Thr)) decreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) |
| pubmed:24653673 | p(HGNC:PPP2R1A, pmod(go:0006468 ! "protein phosphorylation", Ser), pmod(go:0006468 ! "protein phosphorylation", Thr)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:PPP2R1B, pmod(go:0006468 ! "protein phosphorylation", Ser), pmod(go:0006468 ! "protein phosphorylation", Thr)) decreases complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A)) |
| pubmed:24653673 | p(HGNC:PPP2R1B, pmod(go:0006468 ! "protein phosphorylation", Ser), pmod(go:0006468 ! "protein phosphorylation", Thr)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | complex(a(PUBCHEM:5311365), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | complex(a(PUBCHEM:5311365), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | complex(a(PUBCHEM:6913994), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | complex(a(PUBCHEM:6913994), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:SET)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:SET)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:ANP32A) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:ANP32A) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:ANP32A) increases complex(p(HGNC:ANP32A), p(HGNC:PPP2CA)) |
| pubmed:24653673 | p(HGNC:ANP32A) increases complex(p(HGNC:ANP32A), p(HGNC:PPP2CB)) |
| pubmed:24653673 | p(HGNC:ANP32A) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22299660 | p(HGNC:ANP32A) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22299660 | p(HGNC:ANP32A) decreases act(p(FPLX:PPP2)) |
| pubmed:24653673 | complex(p(HGNC:ANP32A), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | complex(p(HGNC:ANP32A), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | a(CHEBI:"metal cation") increases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | a(CHEBI:polyamine) increases act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:21882945 | a(CHEBI:polyamine) decreases act(p(INTERPRO:"Heat shock protein 70 family")) |
| pubmed:24653673 | complex(p(HGNC:LCMT1), p(HGNC:PPP2CA)) regulates complex(GO:"protein phosphatase type 2A complex") |
| pubmed:24653673 | complex(p(HGNC:LCMT1), p(HGNC:PPP2CB)) regulates complex(GO:"protein phosphatase type 2A complex") |
| pubmed:24653673 | complex(p(HGNC:IGBP1), p(HGNC:PPP2CB)) regulates complex(GO:"protein phosphatase type 2A complex") |
| pubmed:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PTPA)) regulates complex(GO:"protein phosphatase type 2A complex") |
| pubmed:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PTPA)) regulates complex(GO:"protein phosphatase type 2A complex") |
| pubmed:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pubmed:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pubmed:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pubmed:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) positiveCorrelation p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) |
| pubmed:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) association p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) |
| pubmed:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) |
| pubmed:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:Tauopathies) |
| pubmed:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates a(GO:microtubule) |
| pubmed:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates bp(MESH:"Neuronal Outgrowth") |
| pubmed:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates p(HGNC:MAPT) |
| pubmed:24653673 | complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pubmed:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pubmed:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pubmed:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) positiveCorrelation p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) |
| pubmed:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) association p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) |
| pubmed:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) |
| pubmed:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:Tauopathies) |
| pubmed:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates a(GO:microtubule) |
| pubmed:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates bp(MESH:"Neuronal Outgrowth") |
| pubmed:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates p(HGNC:MAPT) |
| pubmed:24653673 | complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | g(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | r(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22299660 | r(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | g(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | r(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22299660 | r(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | r(HGNC:PPP2R2C) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | r(HGNC:PPP2R5E) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation", Tyr, 307)) association a(GO:"neurofibrillary tangle") |
| pubmed:24653673 | p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation", Tyr, 307)) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | p(HGNC:SET, frag("?")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | p(HGNC:SET, frag("?")) increases path(MESH:"Alzheimer Disease") |
| pubmed:24653673 | p(HGNC:SET, frag("?")) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) |
| pubmed:24653673 | p(HGNC:IGBP1, frag("?")) regulates complex(GO:"protein phosphatase type 2A complex") |
| pubmed:24653673 | p(HGNC:IGBP1, frag("?")) positiveCorrelation deg(p(HGNC:PPP2CA)) |
| pubmed:24653673 | p(HGNC:IGBP1, frag("?")) positiveCorrelation deg(p(HGNC:PPP2CB)) |
| pubmed:24653673 | p(HGNC:PPP2CA, var("p.Leu309Ala")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | p(HGNC:PPP2CB, var("p.Leu309Ala")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | a(GO:"neurofilament cytoskeleton") negativeCorrelation act(p(HGNC:GSK3B)) |
| pubmed:24653673 | a(GO:"neurofilament cytoskeleton") negativeCorrelation act(p(HGNC:CDK5)) |
| pubmed:24653673 | a(GO:"neurofilament cytoskeleton") negativeCorrelation act(p(FPLX:ERK)) |
| pubmed:21722302 | a(GO:"neurofilament cytoskeleton") association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:24653673 | bp(GO:"negative regulation of synaptic plasticity") positiveCorrelation act(p(HGNC:GSK3B)) |
| pubmed:24653673 | bp(GO:"negative regulation of synaptic plasticity") positiveCorrelation act(p(HGNC:CDK5)) |
| pubmed:24653673 | bp(GO:"negative regulation of synaptic plasticity") positiveCorrelation act(p(FPLX:ERK)) |
| pubmed:30985105 | complex(a(GO:microtubule), p(HGNC:MAPT)) increases act(p(HGNC:MAPT)) |
| pubmed:26631930 | complex(a(GO:microtubule), p(HGNC:MAPT)) increases bp(GO:"microtubule bundle formation") |
| pubmed:26631930 | complex(a(GO:microtubule), p(HGNC:MAPT)) increases bp(GO:"actin cytoskeleton reorganization") |
| pubmed:26631930 | complex(a(GO:microtubule), p(HGNC:MAPT)) negativeCorrelation a(CONSO:"Tau aggregates") |
| pubmed:26631930 | complex(a(GO:microtubule), p(HGNC:MAPT)) decreases a(CONSO:"Tau aggregates") |
| pubmed:24653673 | bp(GO:"one-carbon metabolic process") association p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) |
| pubmed:24653673 | bp(GO:"one-carbon metabolic process") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | bp(GO:"one-carbon metabolic process") decreases bp(CONSO:amyloidogenesis) |
| pubmed:24653673 | bp(GO:"one-carbon metabolic process") decreases p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) |
| pubmed:24653673 | bp(GO:"one-carbon metabolic process") increases bp(GO:cognition) |
| pubmed:24653673 | bp(GO:"one-carbon metabolic process") decreases act(a(CHEBI:amyloid-beta)) |
| pubmed:24653673 | a(CHEBI:folates) decreases p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) |
| pubmed:24653673 | a(CHEBI:folates) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | a(CHEBI:folates) increases p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | path(MESH:"Vitamin B Deficiency") decreases p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) |
| pubmed:24653673 | path(MESH:"Vitamin B Deficiency") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24653673 | path(MESH:"Vitamin B Deficiency") increases p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:12428809 | p(HGNC:MAPK9) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:12428809 | p(FPLX:CK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:12428809 | p(FPLX:PPP1) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21734277 | act(p(FPLX:PPP1)) decreases bp(GO:"axonal transport") |
| pubmed:21489990 | act(p(FPLX:PPP1)) decreases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:12428809 | p(FPLX:PPP3) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30988501 | path(MESH:"Wallerian Degeneration") increases deg(a(MESH:Neurons)) |
| pubmed:12428809 | a(MESH:"Intermediate Filaments") positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:12428809 | a(MESH:"Intermediate Filaments") negativeCorrelation a(MESH:Axons) |
| pubmed:12428809 | a(CONSO:"straight filaments") association path(MESH:"Alzheimer Disease") |
| pubmed:12428809 | p(HGNC:APPL) increases bp(GO:"anterograde axonal transport") |
| pubmed:22299660 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 198)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23088643 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 198)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22299660 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26458742 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23088643 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:20071522 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) isA p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:20071522 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) association complex(p(HGNC:FKBP5), p(HGNC:MAPT)) |
| pubmed:20071522 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) positiveCorrelation p(HGNC:FKBP5) |
| pubmed:21367866 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) positiveCorrelation p(HGNC:CDC37) |
| pubmed:17078951 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) positiveCorrelation p(FPLX:PKA) |
| pubmed:23088643 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) partOf p(CONSO:"Tau epitope, AT8") |
| pubmed:25331948 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) partOf p(CONSO:"Tau epitope, AT8") |
| pubmed:22833681 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) partOf p(CONSO:"Tau epitope, AT8") |
| pubmed:19459590 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) |
| pubmed:22833681 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) |
| pubmed:21734277 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:22299660 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29191965 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27373205 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23088643 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) partOf p(CONSO:"Tau aggregates") |
| pubmed:27373205 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) association a(CONSO:"Tau oligomers") |
| pubmed:22817713 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) association a(CONSO:"Tau oligomers") |
| pubmed:27373205 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) association a(CONSO:"Tau antibody, TNT1") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) decreases p(HGNC:MAPT, frag("1_421")) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) decreases p(HGNC:MAPT, frag("421_*")) |
| pubmed:26671985 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy") |
| pubmed:26671985 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) increases path(MESH:"Cognitive Dysfunction") |
| pubmed:17078951 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) positiveCorrelation p(FPLX:PKA) |
| pubmed:23088643 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) partOf a(GO:"neurofibrillary tangle") |
| pubmed:23088643 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) association a(GO:"neurofibrillary tangle") |
| pubmed:23088643 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) partOf a(MESH:"Neuropil Threads") |
| pubmed:23088643 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) partOf path(MESH:"Plaque, Amyloid") |
| pubmed:23088643 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) association a(CONSO:pretangles) |
| pubmed:11943212 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) partOf p(CONSO:"Tau epitope, AP422") |
| pubmed:23294633 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pubmed:27373205 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:27373205 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) positiveCorrelation p(CONSO:"Tau dimers") |
| pubmed:27373205 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) decreases bp(GO:"anterograde axonal transport") |
| pubmed:22299660 | p(FPLX:PPP2C, pmod(go:0006479 ! "protein methylation")) increases complex(p(FPLX:"PPP2R_A"), p(FPLX:"PPP2R_B"), p(FPLX:PPP2C)) |
| pubmed:22299660 | p(HGNC:ICMT) increases p(FPLX:PPP2C, pmod(go:0006479 ! "protein methylation")) |
| pubmed:22299660 | p(HGNC:ICMT) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22299660 | p(FPLX:PPP2C, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) decreases act(p(FPLX:PPP2)) |
| pubmed:22299660 | p(FPLX:PPP2C, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22299660 | p(FPLX:PPP2C, pmod(go:0006479 ! "protein methylation", Leu, 309)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22299660 | p(FPLX:PPP2C, pmod(go:0006479 ! "protein methylation", Leu, 309)) decreases complex(p(FPLX:"PPP2R_A"), p(FPLX:"PPP2R_B"), p(FPLX:PPP2C)) |
| pubmed:22299660 | p(FPLX:PPP2C, pmod(go:0006468 ! "protein phosphorylation")) association a(MESH:"Neurofibrillary Tangles") |
| pubmed:28083634 | p(HGNC:OTUB1) decreases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:28083634 | p(HGNC:OTUB1) increases complex(p(HGNC:MAPT), p(HGNC:OTUB1)) |
| pubmed:28083634 | p(HGNC:OTUB1) increases complex(p(HGNC:MAPT), p(HGNC:OTUB1)) |
| pubmed:28083634 | p(HGNC:OTUB1) increases a(CONSO:"Tau aggregates") |
| pubmed:28083634 | p(HGNC:OTUB1) increases a(CONSO:"Tau aggregates") |
| pubmed:28083634 | p(HGNC:OTUB1) increases a(CONSO:"Tau aggregates") |
| pubmed:28083634 | p(HGNC:OTUB1) increases a(CONSO:"Tau aggregates") |
| pubmed:28083634 | p(HGNC:OTUB1) negativeCorrelation a(CONSO:"Tau aggregates") |
| pubmed:28083634 | p(HGNC:OTUB1) regulates p(HGNC:MAPT) |
| pubmed:28083634 | p(HGNC:OTUB1) increases p(HGNC:MAPT) |
| pubmed:28083634 | p(HGNC:OTUB1) decreases deg(p(HGNC:MAPT)) |
| pubmed:28083634 | p(HGNC:OTUB1) regulates deg(p(HGNC:MAPT)) |
| pubmed:28083634 | p(HGNC:OTUB1) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:28083634 | p(HGNC:OTUB1) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:28083634 | p(HGNC:OTUB1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:28083634 | p(HGNC:OTUB1) increases a(CONSO:"Tau oligomers") |
| pubmed:28083634 | p(HGNC:OTUB1) increases a(CONSO:"Tau oligomers") |
| pubmed:28083634 | p(HGNC:OTUB1) decreases p(HGNC:MAPT, pmod(go:0070936 ! "protein K48-linked ubiquitination")) |
| pubmed:28083634 | p(HGNC:OTUB1) causesNoChange p(HGNC:MAPT, pmod(go:0070534 ! "protein K63-linked ubiquitination")) |
| pubmed:28083634 | complex(p(HGNC:MAPT), p(HGNC:OTUB1)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28083634 | complex(p(HGNC:MAPT), p(HGNC:OTUB1)) increases a(CONSO:"Tau aggregates") |
| pubmed:28083634 | p(HGNC:USP5) decreases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:28083634 | p(HGNC:USP5) increases complex(p(HGNC:MAPT), p(HGNC:USP5)) |
| pubmed:28083634 | p(HGNC:USP5) causesNoChange a(CONSO:"Tau aggregates") |
| pubmed:28083634 | p(HGNC:USP9X) decreases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:28083634 | p(HGNC:USP9X) increases complex(p(HGNC:MAPT), p(HGNC:USP9X)) |
| pubmed:28083634 | p(HGNC:USP9X) causesNoChange a(CONSO:"Tau aggregates") |
| pubmed:28083634 | p(HGNC:OTUB1, var("p.Cys91Ala")) causesNoChange p(HGNC:MAPT, pmod(go:0070936 ! "protein K48-linked ubiquitination")) |
| pubmed:28083634 | p(HGNC:OTUB1, var("p.Cys91Ala")) causesNoChange deg(p(HGNC:MAPT)) |
| pubmed:28083634 | p(HGNC:OTUB1, var("p.Cys91Ala")) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:28083634 | p(HGNC:OTUB1, frag("?")) decreases p(HGNC:MAPT, pmod(go:0070936 ! "protein K48-linked ubiquitination")) |
| pubmed:28083634 | p(HGNC:OTUB1, frag("?")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:28083634 | p(MGI:Otub1) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:28083634 | p(MGI:Otub1) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:28083634 | p(MGI:Otub1) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:28083634 | p(MGI:Otub1) increases p(MGI:Mapt) |
| pubmed:28083634 | p(MGI:Otub1) increases a(CONSO:"Tau oligomers") |
| pubmed:28083634 | p(MGI:Otub1) increases a(CONSO:"Tau oligomers") |
| pubmed:28083634 | p(MGI:Otub1) increases a(CONSO:"Tau oligomers") |
| pubmed:28083634 | p(MGI:Otub1, var("p.Cys91Ala")) causesNoChange p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:28083634 | p(MGI:Otub1, var("p.Cys91Ala")) causesNoChange a(CONSO:"Tau oligomers") |
| pubmed:28083634 | p(MGI:Otub1, frag("?")) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:30362565 | path(MESH:Autophagy) association path(MESH:"Huntington Disease") |
| pubmed:30837838 | path(MESH:Autophagy) association p(HGNC:MAP1LC3A, loc(GO:"inclusion body")) |
| pubmed:30837838 | path(MESH:Autophagy) association p(HGNC:SQSTM1, loc(GO:"inclusion body")) |
| pubmed:30837838 | path(MESH:Autophagy) association deg(p(HGNC:TARDBP)) |
| pubmed:30837838 | path(MESH:Autophagy) decreases p(HGNC:TARDBP) |
| pubmed:30837838 | path(MESH:Autophagy) increases path(MESH:"Cytotoxicity, Immunologic") |
| pubmed:30837838 | path(MESH:Autophagy) increases deg(p(CONSO:"TDP-43 aggregates")) |
| pubmed:28148553 | bp(GO:"metabolic process") association a(CHEBI:"3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide") |
| pubmed:30362565 | p(HGNCGENEFAMILY:"Pyruvate dehydrogenase complex") increases path(MESH:"Carbohydrate Metabolism") |
| pubmed:20556492 | p(HGNCGENEFAMILY:"Pyruvate dehydrogenase complex") negativeCorrelation path(HP:"Caudate atrophy") |
| pubmed:30362565 | path(MESH:"Carbohydrate Metabolism") decreases path(MESH:"Lipid Metabolism") |
| pubmed:30362565 | path(MESH:"Lipid Metabolism") increases path(CONSO:"mitochondrial dysfunction") |
| pubmed:30362565 | path(MESH:"Lipid Metabolism") increases a(CHEBI:radical) |
| pubmed:30362565 | path(MESH:"Lipid Metabolism") decreases path(MESH:"Carbohydrate Metabolism") |
| pubmed:30362565 | a(CHEBI:meldonium) isA a(MESH:"Cardiotonic Agents") |
| pubmed:30362565 | a(CHEBI:meldonium) increases a(CHEBI:"adenosine triphosphate") |
| pubmed:30362565 | a(CHEBI:meldonium) regulates path(MESH:"Energy Metabolism") |
| pubmed:30362565 | a(CHEBI:meldonium) regulates path(MESH:"Energy Metabolism") |
| pubmed:30362565 | a(CHEBI:meldonium) decreases a(DRUGBANK:L-Carnitine, loc(GO:intracellular)) |
| pubmed:30362565 | a(CHEBI:meldonium) decreases a(CHEBI:"hydroxy-fatty acyl-L-carnitine") |
| pubmed:30362565 | a(CHEBI:meldonium) decreases path(MESH:"Lipid Metabolism") |
| pubmed:30362565 | a(CHEBI:meldonium) increases path(MESH:"Lipid Metabolism") |
| pubmed:30362565 | a(CHEBI:meldonium) decreases path(MESH:Inflammation) |
| pubmed:30362565 | a(CHEBI:meldonium) decreases path(MESH:Apoptosis) |
| pubmed:30362565 | a(CHEBI:meldonium) increases path(MESH:"Recognition (Psychology)") |
| pubmed:30362565 | a(CHEBI:meldonium) increases path(MESH:"Spatial Learning") |
| pubmed:30362565 | a(CHEBI:meldonium) decreases p(HGNC:APP) |
| pubmed:30362565 | a(CHEBI:meldonium) increases path(MESH:"Cell Survival") |
| pubmed:30362565 | a(CHEBI:meldonium) decreases p(CONSO:"huntingtin aggregates") |
| pubmed:30362565 | a(CHEBI:meldonium) increases r(HGNC:PPARGC1A) |
| pubmed:30362565 | a(CHEBI:meldonium) increases r(HGNC:PPARGC1A) |
| pubmed:30362565 | a(CHEBI:meldonium) increases path(MESH:"Cell Enlargement") |
| pubmed:30362565 | a(CHEBI:meldonium) increases path(MESH:Longevity) |
| pubmed:30362565 | a(CHEBI:meldonium) decreases path(MESH:"Motor Skills Disorders") |
| pubmed:30362565 | a(CHEBI:meldonium) decreases path(MESH:Ataxia) |
| pubmed:30362565 | a(MESH:"4'-azidothymidine") increases path(MESH:"Neurotoxicity Syndromes") |
| pubmed:30362565 | p(HGNC:HTT, var("Glu")) increases path(MESH:"Cytotoxicity, Immunologic") |
| pubmed:30362565 | p(HGNC:HTT, var("Glu")) decreases r(HGNC:PPARGC1A) |
| pubmed:30362565 | p(HGNC:HTT, var("Glu")) decreases r(HGNC:PPARGC1A) |
| pubmed:30362565 | p(HGNC:HTT, var("Glu")) decreases p(HGNC:PPARGC1A) |
| pubmed:30362565 | p(HGNC:HTT, var("Glu")) increases a(CHEBI:"reactive oxygen species") |
| pubmed:30362565 | composite(a(CHEBI:meldonium), p(HGNC:HTT, var("Glu"))) increases r(HGNC:PPARGC1A) |
| pubmed:30362565 | composite(a(CHEBI:meldonium), p(HGNC:HTT, var("Glu"))) decreases a(CHEBI:"reactive oxygen species") |
| pubmed:30012004 | bp(GO:"dopamine metabolic process") negativeCorrelation path(MESH:"Huntington Disease") |
| pubmed:30012004 | bp(GO:"D-glutamate metabolic process") negativeCorrelation path(MESH:"Huntington Disease") |
| pubmed:30012004 | bp(GO:"cannabinoid biosynthetic process") negativeCorrelation path(MESH:"Huntington Disease") |
| pubmed:30012004 | bp(GO:"adenosine catabolic process") negativeCorrelation path(MESH:"Huntington Disease") |
| pubmed:30012004 | bp(GO:"psychomotor behavior") negativeCorrelation path(MESH:"Huntington Disease") |
| pubmed:30012004 | bp(GO:"visual learning") negativeCorrelation path(MESH:"Huntington Disease") |
| pubmed:22179319 | path(MESH:Metabolism) association p(HGNC:SIRT1) |
| pubmed:19933700 | path(MESH:Metabolism) association p(HGNC:PPP2R1A) |
| pubmed:22179319 | p(NCBIGENE:34708) causesNoChange p(HGNC:HTT, pmod(CONSO:"CAG repeats")) |
| pubmed:22179319 | p(NCBIGENE:34708) causesNoChange bp(MESH:Neuroprotection) |
| pubmed:27574109 | path(MESH:"Pick Disease of the Brain") positiveCorrelation p(CONSO:"3R tau") |
| pubmed:26655600 | path(MESH:"Pick Disease of the Brain") positiveCorrelation p(CONSO:"3R tau", loc(GO:"Pick body")) |
| pubmed:27574109 | path(MESH:"Pick Disease of the Brain") positiveCorrelation p(CONSO:"4R tau") |
| pubmed:27574109 | path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT) |
| pubmed:27574109 | path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT) |
| pubmed:27574109 | path(MESH:"Pick Disease of the Brain") positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:27574109 | path(MESH:"Pick Disease of the Brain") positiveCorrelation a(CONSO:"Tau oligomers") |
| pubmed:27574109 | path(MESH:"Pick Disease of the Brain") positiveCorrelation a(CONSO:"Tau oligomers") |
| pubmed:27574109 | path(MESH:"Pick Disease of the Brain") positiveCorrelation composite(p(CONSO:"phosphatase-activating domain"), p(HGNC:MAPT)) |
| pubmed:29311797 | path(MESH:"Pick Disease of the Brain") isA path(MESH:Tauopathies) |
| pubmed:27260836 | path(MESH:"Pick Disease of the Brain") positiveCorrelation complex(GO:"Pick body") |
| pubmed:22057784 | path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) |
| pubmed:22057784 | path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) |
| pubmed:22057784 | path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(go:0017014 ! "protein nitrosylation", Tyr, 29)) |
| pubmed:30837838 | path(MESH:"Pick Disease of the Brain") association p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) |
| pubmed:30837838 | path(MESH:"Pick Disease of the Brain") association p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) |
| pubmed:22179319 | path(MESH:Eating) association p(HGNC:HTT, pmod(CONSO:"CAG repeats")) |
| pubmed:22179319 | p(HGNC:PPP1R1B) decreases bp(GO:"striatal medium spiny neuron differentiation") |
| pubmed:22179319 | p(HGNC:PPP1R1B) association p(HGNC:BDNF) |
| pubmed:23393546 | p(HGNC:PPP1R1B) association bp(GO:"dopamine receptor signaling pathway") |
| pubmed:23393546 | p(HGNC:PPP1R1B) association bp(GO:"serotonin receptor signaling pathway") |
| pubmed:23393546 | p(HGNC:PPP1R1B) prognosticBiomarkerFor path(DOID:"Huntington's disease") |
| pubmed:22179319 | path(MESH:"Caloric Restriction") increases p(HGNC:BDNF) |
| pubmed:27013968 | act(p(HGNC:NTRK2, pmod(go:0006468 ! "protein phosphorylation"))) regulates a(CHEBI:dopamine) |
| pubmed:27013968 | act(p(HGNC:NTRK2, pmod(go:0006468 ! "protein phosphorylation"))) regulates a(CHEBI:"2',3'-cyclic AMP") |
| pubmed:22179319 | p(HGNC:SIRT1, pmod(go:0006473 ! "protein acetylation")) association p(HGNC:HTT, pmod(CONSO:"CAG repeats")) |
| pubmed:20556492 | bp(GO:"regulation of succinate dehydrogenase activity") negativeCorrelation path(DOID:"Huntington's disease") |
| pubmed:20556492 | bp(GO:"tricarboxylic acid cycle") negativeCorrelation path(DOID:"Huntington's disease") |
| pubmed:20556492 | path(HP:"Caudate atrophy") decreases act(p(HGNC:ACO2)) |
| pubmed:20556492 | path(HP:"Caudate atrophy") negativeCorrelation p(HGNCGENEFAMILY:"Pyruvate dehydrogenase complex") |
| pubmed:21722302 | bp(GO:"negative regulation of mitochondrial membrane potential") increases bp(GO:"release of cytochrome c from mitochondria") |
| pubmed:20556492 | path(DOID:neuroblastoma) increases p(HGNC:HTT, pmod(CONSO:"CAG repeats"), loc(GO:"mitochondrial outer membrane")) |
| pubmed:21722302 | complex(GO:"mitochondrial permeability transition pore complex") directlyIncreases bp(GO:"regulation of mitochondrial membrane potential") |
| pubmed:21722302 | complex(GO:"mitochondrial permeability transition pore complex") increases bp(GO:"release of cytochrome c from mitochondria") |
| pubmed:21722302 | complex(GO:"mitochondrial permeability transition pore complex") increases p(MESH:Caspases) |
| pubmed:20556492 | a(CHEBI:"cyclosporin A") decreases complex(GO:"mitochondrial permeability transition pore complex") |
| pubmed:20556492 | a(CHEBI:"cyclosporin A") decreases complex(GO:"mitochondrial permeability transition pore complex") |
| pubmed:20556492 | a(CHEBI:"cyclosporin A") increases bp(GO:"calcium import into the mitochondrion") |
| pubmed:20556492 | a(CHEBI:"cyclosporin A") decreases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pubmed:20556492 | a(CHEBI:"cyclosporin A") decreases bp(GO:"calcium ion import") |
| pubmed:20556492 | a(CHEBI:"cyclosporin A") regulates bp(GO:"regulation of membrane potential") |
| pubmed:20556492 | a(CHEBI:ADP) increases bp(GO:"regulation of membrane potential") |
| pubmed:20556492 | complex(p(HGNC:HTT, pmod(CONSO:"CAG repeats")), p(HGNC:ITPR1, frag("?"))) increases act(p(HGNC:ITPR1)) |
| pubmed:20556492 | a(CHEBI:"bongkrekic acid") decreases complex(GO:"mitochondrial permeability transition pore complex") |
| pubmed:20556492 | a(CHEBI:"bongkrekic acid") decreases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pubmed:20556492 | a(CHEBI:"bongkrekic acid") decreases bp(GO:"calcium ion import") |
| pubmed:20556492 | a(CHEBI:"bongkrekic acid") regulates bp(GO:"regulation of membrane potential") |
| pubmed:20556492 | complex(p(HGNC:HTT, pmod(CONSO:"CAG repeats")), p(HGNCGENEFAMILY:"Calcium voltage-gated channel alpha1 subunits")) increases bp(GO:"regulation of voltage-gated calcium channel activity") |
| pubmed:20556492 | complex(p(HGNC:HTT, pmod(CONSO:"CAG repeats")), p(HGNCGENEFAMILY:"Calcium voltage-gated channel auxiliary alpha2delta subunits")) increases bp(GO:"regulation of voltage-gated calcium channel activity") |
| pubmed:20556492 | p(FB:htt, pmod(CONSO:"CAG repeats")) increases path(HP:Neurodegeneration) |
| pubmed:20556492 | p(FB:Ca-alpha1D) decreases path(HP:Neurodegeneration) |
| pubmed:20556492 | complex(p(HGNC:CREBBP), p(HGNC:HTT, pmod(CONSO:"CAG repeats")), p(HGNC:TAF4)) negativeCorrelation act(p(HGNC:CREBBP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:20556492 | complex(p(HGNC:CREBBP), p(HGNC:HTT, pmod(CONSO:"CAG repeats")), p(HGNC:TAF4)) increases path(MESH:"Cytotoxicity, Immunologic") |
| pubmed:20556492 | complex(p(HGNC:CREBBP), p(HGNC:HTT, pmod(CONSO:"CAG repeats")), p(HGNC:TAF4)) increases p(HGNC:HTT, pmod(CONSO:"CAG repeats")) |
| pubmed:28173111 | bp(MESH:"Mitochondrial Dynamics") negativeCorrelation r(MGI:Dnm1l) |
| pubmed:28420982 | bp(GO:"mitochondrion organization") decreases bp(HP:Neurodegeneration) |
| pubmed:20556492 | complex(p(HGNC:NRF1), p(HGNC:PPARG), p(HGNC:PPARGC1A)) regulates bp(GO:"cellular respiration") |
| pubmed:27299292 | bp(GO:"lipid biosynthetic process") negativeCorrelation p(HGNC:TFEB) |
| pubmed:20556492 | complex(p(HGNC:CREBBP), p(HGNC:TAF4)) regulates r(HGNC:PPARGC1A) |
| pubmed:20556492 | a(CHEBI:thiazolidinediones) decreases path(DOID:"Alzheimer's disease") |
| pubmed:20556492 | a(CHEBI:thiazolidinediones) decreases path(DOID:"Parkinson's disease") |
| pubmed:20556492 | a(CHEBI:thiazolidinediones) decreases path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:20556492 | a(CHEBI:thiazolidinediones) decreases path(EFO:stroke) |
| pubmed:20556492 | a(CHEBI:thiazolidinediones) decreases path(DOID:"multiple sclerosis") |
| pubmed:29687724 | path(MESH:Dystonia) association path(MESH:"Huntington Disease") |
| pubmed:29687724 | path(MESH:Dystonia) association path(MESH:"Neural Pathways") |
| pubmed:29687724 | path(MESH:Dystonia) association a(CHEBI:dopamine) |
| pubmed:29687724 | path(MESH:"Neural Pathways") association path(MESH:Chorea) |
| pubmed:29687724 | path(MESH:"Neural Pathways") association path(MESH:Dystonia) |
| pubmed:29687724 | path(MESH:"Neural Pathways") association path(MESH:"Huntington Disease") |
| pubmed:29687724 | a(CHEBI:risperidone) decreases a(CHEBI:dopamine) |
| pubmed:29687724 | a(CHEBI:risperidone) decreases path(MESH:Chorea) |
| pubmed:29687724 | a(CHEBI:risperidone) decreases path(MESH:Dystonia) |
| pubmed:29687724 | a(CHEBI:risperidone) decreases path(MESH:"Stereotypic Movement Disorder") |
| pubmed:29687724 | a(CHEBI:olanzapine) decreases a(CHEBI:dopamine) |
| pubmed:29687724 | a(CHEBI:olanzapine) decreases path(MESH:Chorea) |
| pubmed:29687724 | a(CHEBI:olanzapine) decreases path(MESH:Dystonia) |
| pubmed:29687724 | a(PUBCHEM:73437646) isA a(PUBCHEM:6018) |
| pubmed:29687724 | a(PUBCHEM:73437646) decreases path(MESH:Chorea) |
| pubmed:29687724 | path(MESH:"Schizophrenia, Disorganized") association path(MESH:"Huntington Disease") |
| pubmed:29687724 | path(MESH:"Schizophrenia, Disorganized") decreases path(MESH:Movement) |
| pubmed:29687724 | a(CHEBI:valproate) decreases path(MESH:"Irritable Mood") |
| pubmed:29687724 | a(CHEBI:valproate) decreases path(MESH:Aggression) |
| pubmed:29687724 | a(CHEBI:carbamazepine) decreases path(MESH:"Irritable Mood") |
| pubmed:29687724 | a(CHEBI:carbamazepine) decreases path(MESH:Aggression) |
| pubmed:29687724 | a(MESH:"Serotonin Uptake Inhibitors") decreases path(MESH:"Irritable Mood") |
| pubmed:29687724 | a(MESH:"Serotonin Uptake Inhibitors") decreases path(MESH:Aggression) |
| pubmed:29687724 | a(MESH:"Serotonin Uptake Inhibitors") decreases path(MESH:"Obsessive-Compulsive Disorder") |
| pubmed:29687724 | a(MESH:"Serotonin Uptake Inhibitors") decreases path(HP:Rigidity) |
| pubmed:30988501 | a(MESH:"Serotonin Uptake Inhibitors") decreases p(HGNC:IL6) |
| pubmed:30988501 | a(MESH:"Serotonin Uptake Inhibitors") decreases p(HGNC:IL1B) |
| pubmed:29687724 | a(CHEBI:clomipramine) decreases path(MESH:"Obsessive-Compulsive Disorder") |
| pubmed:29687724 | a(CHEBI:clomipramine) decreases path(HP:Rigidity) |
| pubmed:26195256 | path(MESH:Thinking) decreases path(MESH:"Alzheimer Disease") |
| pubmed:29687724 | a(PUBCHEM:33032) increases bp(GO:cognition) |
| pubmed:29687724 | a(PUBCHEM:33032) increases bp(GO:"motor behavior") |
| pubmed:29687724 | a(CHEBI:amantadine) decreases a(PUBCHEM:33032) |
| pubmed:29687724 | a(CHEBI:amantadine) association path(MESH:"Huntington Disease") |
| pubmed:29687724 | a(CHEBI:amantadine) decreases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") |
| pubmed:29687724 | a(PUBCHEM:9795739) decreases a(CHEBI:dopamine) |
| pubmed:29687724 | a(PUBCHEM:9795739) association path(MESH:"Huntington Disease") |
| pubmed:29687724 | a(PUBCHEM:9795739) causesNoChange bp(GO:"motor behavior") |
| pubmed:27013968 | p(HGNC:HTT, pmod(HBP:"CAG repeats")) increases path(MESH:"Huntington Disease") |
| pubmed:27013968 | p(HGNC:HTT, pmod(HBP:"CAG repeats")) association path(MESH:"Huntington Disease") |
| pubmed:27013968 | p(HGNC:HTT, pmod(HBP:"CAG repeats")) negativeCorrelation bp(GO:"synaptic transmission, dopaminergic") |
| pubmed:27013968 | p(HGNC:HTT, pmod(HBP:"CAG repeats")) negativeCorrelation bp(GO:"synaptic transmission, glutamatergic") |
| pubmed:27013968 | p(HGNC:HTT, pmod(HBP:"CAG repeats")) negativeCorrelation bp(GO:"mRNA transcription") |
| pubmed:27013968 | p(HGNC:HTT, pmod(HBP:"CAG repeats")) negativeCorrelation p(HGNC:PDE10A) |
| pubmed:27013968 | p(HGNC:HTT, pmod(HBP:"CAG repeats")) negativeCorrelation p(HGNC:PTPN5) |
| pubmed:27013968 | p(HGNC:HTT, pmod(HBP:"CAG repeats")) negativeCorrelation p(HGNC:RASD2) |
| pubmed:27013968 | p(HGNC:HTT, pmod(HBP:"CAG repeats")) negativeCorrelation act(p(HGNC:BDNF), ma(GO:"brain-derived neurotrophic factor binding")) |
| pubmed:27013968 | p(HGNC:HTT, pmod(HBP:"CAG repeats")) decreases p(HGNC:BDNF) |
| pubmed:27013968 | p(HGNC:HTT, pmod(HBP:"CAG repeats")) negativeCorrelation act(p(HGNC:NTRK2), ma(GO:"neurotrophin TRKB receptor binding")) |
| pubmed:27013968 | p(HGNC:HTT, pmod(HBP:"CAG repeats")) decreases r(HGNC:BDNF) |
| pubmed:27013968 | p(HGNC:HTT, pmod(HBP:"CAG repeats")) decreases bp(GO:"ERK1 and ERK2 cascade") |
| pubmed:27013968 | a(MESH:"Basal Ganglia") increases act(a(GO:"glutamatergic synapse", loc(MESH:Thalamus))) |
| pubmed:27013968 | a(MESH:"Basal Ganglia") increases act(a(GO:"dopaminergic synapse")) |
| pubmed:27013968 | act(a(GO:"dopaminergic synapse")) increases bp(GO:"locomotory behavior") |
| pubmed:14556719 | a(GO:"dopaminergic synapse") association a(MESH:"Lewy Bodies") |
| pubmed:27013968 | p(HGNC:PDE10A) negativeCorrelation p(HGNC:HTT, pmod(HBP:"CAG repeats")) |
| pubmed:27013968 | p(HGNC:RASD2) negativeCorrelation p(HGNC:HTT, pmod(HBP:"CAG repeats")) |
| pubmed:27013968 | complex(p(HGNC:BDNF), p(HGNC:NTRK2)) increases bp(MESH:"Cell Survival") |
| pubmed:27013968 | complex(p(HGNC:BDNF), p(HGNC:NTRK2)) decreases path(MESH:"Huntington Disease") |
| pubmed:27013968 | complex(p(HGNC:BDNF), p(HGNC:NTRK2)) increases p(HGNC:NTRK2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27013968 | complex(p(HGNC:BDNF), p(HGNC:NTRK2)) increases p(PFAM:DARPP-32) |
| pubmed:23393546 | complex(p(HGNC:BDNF), p(HGNC:NTRK2)) increases bp(GO:"ERK1 and ERK2 cascade") |
| pubmed:27013968 | g(HGNC:BDNF) increases p(HGNC:BDNF) |
| pubmed:27013968 | a(CHEBI:"2',3'-cyclic AMP") regulates p(PFAM:DARPP-32) |
| pubmed:27013968 | p(PFAM:DARPP-32) increases bp(GO:"cellular process") |
| pubmed:27013968 | composite(p(HGNC:BDNF), p(HGNC:HTT, pmod(HBP:"CAG repeats"))) increases bp(GO:"maintenance of cell number") |
| pubmed:27013968 | composite(p(HGNC:BDNF), p(HGNC:HTT, pmod(HBP:"CAG repeats"))) decreases bp(MESH:"Cell Survival") |
| pubmed:27013968 | composite(p(HGNC:BDNF), p(HGNC:HTT, pmod(HBP:"CAG repeats"))) increases bp(MESH:Apoptosis) |
| pubmed:27013968 | composite(p(HGNC:BDNF), p(HGNC:HTT, pmod(HBP:"CAG repeats"))) decreases p(PFAM:DARPP-32) |
| pubmed:27013968 | composite(p(HGNC:BDNF), p(HGNC:HTT, pmod(HBP:"CAG repeats"))) decreases p(HGNC:NTRK2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27013968 | composite(p(HGNC:BDNF), p(HGNC:HTT, pmod(HBP:"CAG repeats"))) increases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27013968 | composite(p(HGNC:BDNF), p(HGNC:HTT, pmod(HBP:"CAG repeats"))) increases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21722302 | path(HP:Dyskinesia) prognosticBiomarkerFor path(MESH:"Parkinson Disease") |
| pubmed:30027901 | path(HP:"Cognitive impairment") decreases bp(GO:"motor learning") |
| pubmed:30027901 | path(HP:"Cognitive impairment") increases path(HP:"Neurological speech impairment") |
| pubmed:30027901 | path(HP:"Cognitive impairment") increases path(MESH:"Perceptual Disorders") |
| pubmed:30027901 | path(HP:"Abnormal putamen morphology") increases bp(GO:"neuron death") |
| pubmed:30027901 | complex(p(HGNC:HTT, pmod(CONSO:"CAG repeats")), p(MESH:Proteins)) decreases act(p(MESH:Proteins)) |
| pubmed:30027901 | path(MESH:"Westphal disease") association path(MESH:"Huntington Disease") |
| pubmed:30027901 | path(MESH:"Westphal disease") increases path(HP:Hypokinesia) |
| pubmed:30027901 | path(MESH:"Westphal disease") decreases path(MESH:"Motor Activity") |
| pubmed:30027901 | bp(GO:"intracellular transport") association act(p(HGNC:HTT)) |
| pubmed:30027901 | bp(GO:"intracellular transport") association p(HGNC:HTT) |
| pubmed:25784053 | bp(GO:"intracellular transport") association p(FPLX:"CCT_complex") |
| pubmed:21722302 | bp(CONSO:"protein aggregation") increases bp(MESH:"Cell Death") |
| pubmed:21722302 | bp(CONSO:"protein aggregation") association path(MESH:"Neurodegenerative Diseases") |
| pubmed:21722302 | bp(CONSO:"protein aggregation") association path(MESH:"Alzheimer Disease") |
| pubmed:21722302 | bp(CONSO:"protein aggregation") association path(MESH:"Parkinson Disease") |
| pubmed:21722302 | bp(CONSO:"protein aggregation") association path(MESH:"Amyloidosis, Cerebral, with Spongiform Encephalopathy") |
| pubmed:21722302 | bp(CONSO:"protein aggregation") association path(MESH:"Brain Injuries, Traumatic") |
| pubmed:21722302 | bp(CONSO:"protein aggregation") association path(MESH:"Brain Ischemia") |
| pubmed:21722302 | bp(CONSO:"protein aggregation") increases a(MESH:"Prion Proteins") |
| pubmed:21722302 | bp(CONSO:"protein aggregation") increases a(CONSO:"amyloid-beta aggregates") |
| pubmed:30027901 | path(HP:"Abnormality of the cerebral subcortex") decreases bp(GO:"learning or memory") |
| pubmed:30027901 | p(HGNC:GAD1) increases a(CHEBI:"gamma-aminobutyric acid") |
| pubmed:23393546 | p(HGNC:GAD1) association path(DOID:"Huntington's disease") |
| pubmed:23393546 | p(HGNC:GAD1) association path(DOID:"Huntington's disease") |
| pubmed:30027901 | path(HP:"Cerebellar atrophy") decreases a(CONSO:"Purkinje cell layer of cerebellar cortex") |
| pubmed:29221819 | a(CONSO:"Purkinje cell layer of cerebellar cortex") negativeCorrelation p(MGI:Dyrk1a) |
| pubmed:30027901 | p(HGNC:TH) increases a(CHEBI:dopamine) |
| pubmed:29191965 | p(HGNC:TH) regulates a(CHEBI:dopamine) |
| pubmed:29191965 | p(HGNC:TH) regulates a(CHEBI:serotonin) |
| pubmed:29191965 | p(HGNC:TH) regulates act(p(HGNC:DDC)) |
| pubmed:30027901 | a(MESH:"Hydroxyindoleacetic Acid") association a(CHEBI:serotonin) |
| pubmed:30027901 | p(HGNC:CTH) increases a(CHEBI:L-cysteine) |
| pubmed:30027901 | a(CHEBI:L-cysteine) increases bp(MESH:Neuroprotection) |
| pubmed:22908190 | p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination")) increases deg(p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"))) |
| pubmed:22908190 | p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination")) increases complex(a(GO:"proteasome regulatory particle"), p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"))) |
| pubmed:27181519 | p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination")) negativeCorrelation bp(GO:"stress granule assembly") |
| pubmed:27181519 | p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"proteasome complex")) increases deg(p(MESH:Proteins)) |
| pubmed:30027901 | p(HGNC:HTT, frag("1_17"), pmod(CONSO:"CAG repeats")) increases tloc(p(HGNC:HTT, pmod(CONSO:"CAG repeats")), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:30027901 | p(HGNC:HTT, frag("1_17"), pmod(CONSO:"CAG repeats")) regulates a(CONSO:"huntingtin aggregates") |
| pubmed:30027901 | p(HGNC:HTT, frag("1_17"), pmod(CONSO:"CAG repeats"), pmod(go:0006468 ! "protein phosphorylation")) regulates a(CONSO:"huntingtin aggregates") |
| pubmed:30027901 | bp(GO:"nuclear pore complex assembly") increases bp(GO:"nucleocytoplasmic transport") |
| pubmed:30027901 | act(p(HGNC:ZDHHC17)) regulates bp(GO:"intracellular transport") |
| pubmed:30027901 | p(HGNC:HTT, pmod(CONSO:"CAG repeats"), pmod(go:0018345 ! "protein palmitoylation", Cys, 214)) decreases act(p(HGNC:ZDHHC17)) |
| pubmed:30027901 | p(HGNC:ZDHHC17, pmod(go:0018345 ! "protein palmitoylation")) increases act(p(HGNC:ZDHHC17)) |
| pubmed:30740335 | a(MESH:"Protein Aggregates") increases path(HBP:proteotoxicity) |
| pubmed:27299292 | path(MESH:"Protein Aggregation, Pathological") negativeCorrelation bp(GO:"autophagosome assembly") |
| pubmed:27299292 | path(MESH:"Protein Aggregation, Pathological") negativeCorrelation act(p(HGNC:TFEB)) |
| pubmed:27299292 | path(MESH:"Protein Aggregation, Pathological") decreases p(HGNC:TPP1) |
| pubmed:27299292 | path(MESH:"Protein Aggregation, Pathological") negativeCorrelation bp(GO:autophagy) |
| pubmed:25784053 | path(MESH:"Protein Aggregation, Pathological") association bp(CONSO:Proteostasis) |
| pubmed:25784053 | path(MESH:"Protein Aggregation, Pathological") association path(MESH:"Neurodegenerative Diseases") |
| pubmed:25784053 | path(MESH:"Protein Aggregation, Pathological") negativeCorrelation p(HGNC:HSPA1A) |
| pubmed:25784053 | path(MESH:"Protein Aggregation, Pathological") negativeCorrelation p(HGNC:HSPA1B) |
| pubmed:25784053 | path(MESH:"Protein Aggregation, Pathological") negativeCorrelation p(HGNC:DNAJB1) |
| pubmed:24706768 | path(MESH:"Protein Aggregation, Pathological") decreases act(p(HGNC:HSPA8)) |
| pubmed:24706768 | path(MESH:"Protein Aggregation, Pathological") decreases bp(GO:"clathrin-dependent endocytosis") |
| pubmed:27574109 | path(MESH:"Protein Aggregation, Pathological") positiveCorrelation p(CONSO:"3R tau") |
| pubmed:27574109 | path(MESH:"Protein Aggregation, Pathological") positiveCorrelation p(CONSO:"3R tau") |
| pubmed:27574109 | path(MESH:"Protein Aggregation, Pathological") positiveCorrelation p(CONSO:"4R tau") |
| pubmed:27574109 | path(MESH:"Protein Aggregation, Pathological") positiveCorrelation p(CONSO:"4R tau") |
| pubmed:27574109 | path(MESH:"Protein Aggregation, Pathological") positiveCorrelation p(CONSO:"Tau isoform F (441 aa)") |
| pubmed:28669544 | path(MESH:"Protein Aggregation, Pathological") association path(DOID:"neurodegenerative disease") |
| pubmed:30837838 | path(MESH:"Protein Aggregation, Pathological") association complex(p(HGNC:TARDBP, frag("1_102")), p(HGNC:TARDBP, frag("1_102"))) |
| pubmed:30027901 | r(HGNC:HTT) increases complex(p(HGNC:HTT), p(HGNC:OPTN)) |
| pubmed:30027901 | complex(p(HGNC:HTT), p(HGNC:OPTN)) increases bp(GO:"regulation of autophagosome assembly") |
| pubmed:30116051 | p(HGNC:OPTN) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:OPTN) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:27181519 | p(HGNC:OPTN) association path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:27181519 | p(HGNC:OPTN) increases bp(GO:autophagy) |
| pubmed:27181519 | p(HGNC:OPTN) increases deg(p(HGNC:HTT, var("?"))) |
| pubmed:30027901 | a(MESH:Autophagosomes) association p(HGNC:HTT) |
| pubmed:24027553 | a(MESH:Autophagosomes) positiveCorrelation a(CONSO:"Tau aggregates") |
| pubmed:24027553 | a(MESH:Autophagosomes) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:30027901 | composite(a(MESH:Autophagosomes), a(MESH:Lysosomes)) increases bp(GO:autophagy) |
| pubmed:21722302 | composite(a(MESH:Autophagosomes), a(MESH:Lysosomes)) increases deg(a(MESH:Autophagosomes)) |
| pubmed:30027901 | a(MESH:Lysosomes) association p(HGNC:HTT) |
| pubmed:26968346 | act(a(MESH:Lysosomes)) decreases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:26968346 | a(MESH:Lysosomes) decreases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:26968346 | a(MESH:Lysosomes) increases p(HGNCGENEFAMILY:"MTOR complex 1") |
| pubmed:30108137 | act(a(MESH:Lysosomes)) increases bp(GO:"ATP export") |
| pubmed:27299292 | act(a(MESH:Lysosomes)) negativeCorrelation path(CONSO:"protein aggregation") |
| pubmed:27299292 | act(a(MESH:Lysosomes)) increases path(DOID:"pancreatic ductal adenocarcinoma") |
| pubmed:27299292 | act(a(MESH:Lysosomes)) increases deg(p(HGNC:APP, var("?"))) |
| pubmed:25784053 | a(MESH:Lysosomes) increases bp(MESH:Proteolysis) |
| pubmed:25784053 | a(MESH:Lysosomes) decreases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:24027553 | a(MESH:Lysosomes) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29238289 | act(a(MESH:Lysosomes)) decreases tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30027901 | composite(a(MESH:"Cytoplasmic Vesicles"), p(HGNC:BDNF)) association p(HGNC:HTT) |
| pubmed:30027901 | composite(a(CHEBI:"gamma-aminobutyric acid"), a(MESH:"Cytoplasmic Vesicles")) association p(HGNC:HTT) |
| pubmed:30027901 | p(MGI:Pcm1) increases tloc(p(MGI:Pcm1), fromLoc(GO:"Golgi apparatus"), toLoc(GO:"plasma membrane")) |
| pubmed:30027901 | p(MGI:Pcm1) increases a(GO:cilium) |
| pubmed:29311797 | bp(GO:"regulation of cell cycle") association p(HGNC:HSP90AA1) |
| pubmed:22142809 | bp(GO:"regulation of cell cycle") association p(HGNC:CAV2) |
| pubmed:22142809 | bp(GO:"regulation of cell cycle") association p(HGNC:GNB4) |
| pubmed:22142809 | bp(GO:"regulation of cell cycle") association p(HGNC:LIPA) |
| pubmed:30027901 | bp(GO:"chaperone-mediated protein folding") regulates p(MESH:Proteins, pmod(CONSO:misfolded)) |
| pubmed:30027901 | bp(GO:"lysosomal microautophagy") increases deg(p(MESH:Proteins, pmod(CONSO:misfolded))) |
| pubmed:30562574 | bp(GO:"lysosomal microautophagy") increases tloc(a(MESH:"Cytoplasmic Vesicles"), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) |
| pubmed:22908190 | bp(GO:"lysosomal microautophagy") increases tloc(a(GO:cytoplasm), fromLoc(GO:intracellular), toLoc(GO:lysosome)) |
| pubmed:22908190 | bp(GO:"lysosomal microautophagy") increases tloc(a(GO:cytoplasm), fromLoc(GO:intracellular), toLoc(GO:"multivesicular body")) |
| pubmed:18930136 | bp(GO:"lysosomal microautophagy") increases tloc(a(GO:cytoplasm), fromLoc(GO:intracellular), toLoc(GO:lysosome)) |
| pubmed:29626319 | bp(GO:"lysosomal microautophagy") increases bp(GO:"cellular protein catabolic process") |
| pubmed:29626319 | bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | bp(GO:"lysosomal microautophagy") decreases a(CONSO:"Tau aggregates") |
| pubmed:29626319 | bp(GO:"lysosomal microautophagy") increases p(HGNC:MAPT, frag("?")) |
| pubmed:27491084 | bp(CONSO:Proteostasis) association p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") |
| pubmed:27491084 | bp(CONSO:Proteostasis) association p(HGNC:HSPD1) |
| pubmed:27491084 | bp(CONSO:Proteostasis) association p(FPLX:HSPA) |
| pubmed:27491084 | bp(CONSO:Proteostasis) association p(HGNC:TPR) |
| pubmed:27491084 | bp(CONSO:Proteostasis) association p(FPLX:HSPB) |
| pubmed:27491084 | bp(CONSO:Proteostasis) association p(FPLX:HSP90) |
| pubmed:29311797 | bp(CONSO:Proteostasis) association p(FPLX:HSP90) |
| pubmed:27491084 | bp(CONSO:Proteostasis) association p(HGNCGENEFAMILY:"AAA ATPases") |
| pubmed:23746257 | bp(CONSO:Proteostasis) association bp(GO:"inflammatory response") |
| pubmed:23746257 | bp(CONSO:Proteostasis) association bp(GO:"response to oxidative stress") |
| pubmed:23746257 | bp(CONSO:Proteostasis) association bp(GO:"behavioral response to starvation") |
| pubmed:23746257 | bp(CONSO:Proteostasis) negativeCorrelation bp(GO:"cell death") |
| pubmed:25784053 | bp(CONSO:Proteostasis) association bp(MESH:"Protein Biosynthesis") |
| pubmed:25784053 | bp(CONSO:Proteostasis) association bp(GO:"protein folding") |
| pubmed:25784053 | bp(CONSO:Proteostasis) association path(MESH:"Protein Aggregation, Pathological") |
| pubmed:25784053 | bp(CONSO:Proteostasis) association bp(MESH:Proteolysis) |
| pubmed:25784053 | bp(CONSO:Proteostasis) decreases bp(MESH:Aging) |
| pubmed:21882945 | bp(CONSO:Proteostasis) regulates p(HGNC:MAPT) |
| pubmed:21882945 | bp(CONSO:Proteostasis) regulates a(MESH:Proteins) |
| pubmed:27181519 | bp(CONSO:Proteostasis) negativeCorrelation path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:30027901 | path(HP:Parkinsonism) increases path(HP:"Abnormal saccadic eye movements") |
| pubmed:30027901 | path(HP:Parkinsonism) increases path(DOID:"cerebellar ataxia") |
| pubmed:30027901 | bp(GO:"cellular response to drug") decreases path(MESH:Chorea) |
| pubmed:30027901 | bp(GO:"cellular response to drug") decreases a(CHEBI:dopamine) |
| pubmed:30027901 | bp(GO:"cellular response to drug") decreases p(HGNCGENEFAMILY:"Dopamine receptors") |
| pubmed:30027901 | a(CHEBI:reserpine) decreases path(MESH:"Huntington Disease") |
| pubmed:30027901 | a(CHEBI:tetrabenazine) decreases path(MESH:"Huntington Disease") |
| pubmed:30027901 | a(CHEBI:tetrabenazine) decreases path(MESH:"Huntington Disease") |
| pubmed:30027901 | a(CHEBI:tetrabenazine) decreases p(HGNC:SLC18A2) |
| pubmed:30027901 | a(CHEBI:tetrabenazine) decreases a(CHEBI:dopamine) |
| pubmed:30027901 | a(CHEBI:tetrabenazine) decreases a(CHEBI:serotonin) |
| pubmed:30027901 | a(CHEBI:tetrabenazine) decreases a(DRUGBANK:Norepinephrine) |
| pubmed:30027901 | a(CHEBI:tetrabenazine) decreases path(HP:Hyperkinesis) |
| pubmed:30027901 | a(CHEBI:tetrabenazine) decreases path(HP:Hyperkinesis) |
| pubmed:30027901 | a(CHEBI:tetrabenazine) decreases path(MESH:Chorea) |
| pubmed:30027901 | a(CHEBI:tetrabenazine) decreases path(MESH:Chorea) |
| pubmed:30027901 | a(CHEBI:phenothiazines) decreases path(MESH:"Huntington Disease") |
| pubmed:21882945 | a(CHEBI:phenothiazines) decreases a(CONSO:"Tau aggregates") |
| pubmed:30027901 | a(MESH:Butyrophenones) decreases path(MESH:"Huntington Disease") |
| pubmed:30027901 | composite(a(CHEBI:"lithium carbonate"), a(CHEBI:haloperidol)) causesNoChange path(MESH:Chorea) |
| pubmed:30027901 | composite(a(CHEBI:"lithium carbonate"), a(CHEBI:haloperidol)) decreases path(HP:Irritability) |
| pubmed:30027901 | composite(a(CHEBI:"lithium carbonate"), a(CHEBI:haloperidol)) decreases path(MESH:Anger) |
| pubmed:30027901 | composite(a(CHEBI:"lithium carbonate"), a(CHEBI:haloperidol)) decreases path(MESH:Depression) |
| pubmed:30027901 | a(CHEBI:"lithium carbonate") causesNoChange path(MESH:Chorea) |
| pubmed:30027901 | a(MESH:Placebos) causesNoChange path(MESH:Chorea) |
| pubmed:30027901 | a(PUBCHEM:5467) causesNoChange path(MESH:"Motor Disorders") |
| pubmed:30027901 | a(CHEBI:muscimol) increases complex(GO:"GABA receptor complex") |
| pubmed:30027901 | a(CHEBI:muscimol) causesNoChange path(MESH:"Motor Disorders") |
| pubmed:30027901 | a(CHEBI:muscimol) causesNoChange path(HP:"Cognitive impairment") |
| pubmed:30027901 | a(CHEBI:muscimol) decreases path(MESH:Chorea) |
| pubmed:30027901 | a(CHEBI:muscimol) decreases path(HP:Hyperkinesis) |
| pubmed:30027901 | a(CHEBI:muscimol) increases path(DOID:dystonia) |
| pubmed:30027901 | a(DRUGBANK:Pridopidine) decreases p(HGNC:DRD2) |
| pubmed:30027901 | p(HGNC:COQ10A) association act(complex(GO:"mitochondrial respiratory chain complex I")) |
| pubmed:30027901 | p(HGNC:COQ10A) decreases path(MESH:"Huntington Disease") |
| pubmed:30027901 | p(HGNC:COQ10A) causesNoChange path(MESH:"Huntington Disease") |
| pubmed:30027901 | act(complex(GO:"mitochondrial respiratory chain complex I")) association p(HGNC:COQ10A) |
| pubmed:26631930 | act(complex(GO:"mitochondrial respiratory chain complex I")) decreases p(HGNC:SRSF2) |
| pubmed:30027901 | a(DRUGBANK:Remacemide) decreases a(CHEBI:"N-methyl-D-aspartic acid") |
| pubmed:30027901 | a(DRUGBANK:Remacemide) causesNoChange path(MESH:"Huntington Disease") |
| pubmed:30027901 | a(DRUGBANK:Remacemide) increases path(HP:Nausea) |
| pubmed:30027901 | a(DRUGBANK:Remacemide) increases path(HP:Vomiting) |
| pubmed:30027901 | a(DRUGBANK:Remacemide) increases path(MESH:Dizziness) |
| pubmed:30027901 | a(CHEBI:creatine) decreases bp(MESH:"Oxidative Stress") |
| pubmed:30027901 | a(CHEBI:creatine) decreases path(HP:Neurodegeneration) |
| pubmed:30027901 | a(CHEBI:creatine) causesNoChange bp(MESH:"Muscle Strength") |
| pubmed:30027901 | a(CHEBI:creatine) causesNoChange bp(GO:cognition) |
| pubmed:30027901 | tloc(a(CHEBI:"D-glutamate residue"), fromLoc(GO:cytoplasm), toLoc(GO:"extracellular space")) association path(MESH:"Huntington Disease") |
| pubmed:30027901 | p(HGNCGENEFAMILY:Interleukins) biomarkerFor bp(MESH:Neuroprotection) |
| pubmed:30027901 | a(CHEBI:"8-hydroxy-2'-deoxyguanosine") biomarkerFor bp(MESH:Neuroprotection) |
| pubmed:23393546 | p(HGNC:NF2) positiveCorrelation bp(GO:"ERK1 and ERK2 cascade") |
| pubmed:23393546 | a(CHEBI:pizotifen) increases bp(MESH:"Cell Survival") |
| pubmed:23393546 | a(CHEBI:pizotifen) causesNoChange bp(MESH:"Cell Survival") |
| pubmed:23393546 | a(CHEBI:pizotifen) increases bp(GO:"MAPK cascade") |
| pubmed:23393546 | a(CHEBI:pizotifen) increases bp(GO:"MAPK cascade") |
| pubmed:23393546 | a(CHEBI:pizotifen) increases bp(GO:"motor behavior") |
| pubmed:23393546 | a(CHEBI:pizotifen) increases bp(GO:"motor behavior") |
| pubmed:23393546 | a(CHEBI:pizotifen) increases bp(GO:"motor behavior") |
| pubmed:23393546 | a(CHEBI:pizotifen) increases bp(GO:"motor behavior") |
| pubmed:23393546 | a(CHEBI:pizotifen) decreases path(CONSO:Neurodegeneration) |
| pubmed:23393546 | a(CHEBI:pizotifen) decreases path(MESH:"Striatal Degeneration, Autosomal Dominant") |
| pubmed:23393546 | a(CHEBI:pizotifen) increases a(CHEBI:"adenosine triphosphate") |
| pubmed:23393546 | a(CHEBI:pizotifen) causesNoChange a(CHEBI:"adenosine triphosphate") |
| pubmed:23393546 | a(CHEBI:pizotifen) decreases p(HGNC:CASP3) |
| pubmed:23393546 | a(CHEBI:pizotifen) decreases p(HGNC:CASP7) |
| pubmed:23393546 | a(CHEBI:pizotifen) increases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation", Thr, 202)) |
| pubmed:23393546 | a(CHEBI:pizotifen) decreases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation", Thr, 202)) |
| pubmed:23393546 | a(CHEBI:pizotifen) decreases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation", Thr, 202)) |
| pubmed:23393546 | a(CHEBI:pizotifen) increases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation", Tyr, 204)) |
| pubmed:23393546 | a(CHEBI:pizotifen) increases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation", Tyr, 204)) |
| pubmed:23393546 | a(CHEBI:pizotifen) increases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23393546 | a(CHEBI:pizotifen) increases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23393546 | a(CHEBI:pizotifen) increases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23393546 | a(CHEBI:pizotifen) increases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23393546 | a(CHEBI:pizotifen) increases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23393546 | a(CHEBI:pizotifen) increases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23393546 | a(CHEBI:pizotifen) decreases a(CHEBI:serotonin) |
| pubmed:23393546 | a(CHEBI:pizotifen) decreases path(DOID:migraine) |
| pubmed:23393546 | a(CHEBI:pizotifen) increases p(HGNC:HTR1A) |
| pubmed:23393546 | a(CHEBI:pizotifen) increases p(HGNC:PPP1R1B) |
| pubmed:23393546 | a(CHEBI:pizotifen) increases p(HGNC:PPP1R1B) |
| pubmed:23393546 | a(CHEBI:pizotifen) increases p(HGNC:PPP1R1B) |
| pubmed:23393546 | a(CHEBI:pizotifen) increases p(HGNC:GRM2) |
| pubmed:23393546 | a(CHEBI:pizotifen) increases p(HGNC:GRM3) |
| pubmed:23393546 | a(CHEBI:pizotifen) causesNoChange p(HGNC:DRD2) |
| pubmed:23393546 | a(CHEBI:pizotifen) causesNoChange p(HGNC:GAD2) |
| pubmed:23393546 | a(CHEBI:pizotifen) causesNoChange p(HGNC:GAD1) |
| pubmed:23393546 | a(CHEBI:pizotifen) causesNoChange p(HGNC:HTR1B) |
| pubmed:23393546 | a(CHEBI:pizotifen) decreases bp(GO:"negative regulation of cell volume") |
| pubmed:23393546 | a(CHEBI:pizotifen) decreases bp(GO:"negative regulation of cell volume") |
| pubmed:23393546 | a(CHEBI:pizotifen) isA a(CHEBI:"neuroprotective agent") |
| pubmed:23393546 | a(CHEBI:pizotifen) causesNoChange p(HGNC:HTT) |
| pubmed:23393546 | a(CHEBI:pizotifen) decreases path(MESH:Neuropathology) |
| pubmed:23393546 | a(CHEBI:cyproheptadine) increases a(CHEBI:"adenosine triphosphate") |
| pubmed:23393546 | a(CHEBI:cyproheptadine) causesNoChange a(CHEBI:"adenosine triphosphate") |
| pubmed:23393546 | a(CHEBI:cyproheptadine) decreases p(HGNC:CASP3) |
| pubmed:23393546 | a(CHEBI:cyproheptadine) decreases p(HGNC:CASP7) |
| pubmed:23393546 | a(CHEBI:cyproheptadine) causesNoChange bp(MESH:"Cell Survival") |
| pubmed:23393546 | a(CHEBI:cyproheptadine) increases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation", Thr, 202)) |
| pubmed:23393546 | a(CHEBI:cyproheptadine) increases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation", Tyr, 204)) |
| pubmed:23393546 | a(CHEBI:loxapine) increases a(CHEBI:"adenosine triphosphate") |
| pubmed:23393546 | a(CHEBI:loxapine) causesNoChange a(CHEBI:"adenosine triphosphate") |
| pubmed:23393546 | a(CHEBI:loxapine) decreases p(HGNC:CASP3) |
| pubmed:23393546 | a(CHEBI:loxapine) causesNoChange bp(MESH:"Cell Survival") |
| pubmed:23393546 | a(CHEBI:loxapine) increases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation", Thr, 202)) |
| pubmed:23393546 | a(CHEBI:loxapine) increases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation", Tyr, 204)) |
| pubmed:23393546 | p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation", Thr, 202)) increases bp(GO:"MAPK cascade") |
| pubmed:23393546 | p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation", Tyr, 204)) increases bp(GO:"MAPK cascade") |
| pubmed:23393546 | a(CHEBI:"dimethyl sulfoxide") increases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23393546 | a(CHEBI:"dimethyl sulfoxide") increases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23393546 | composite(a(CHEBI:pizotifen), p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation"))) increases bp(MESH:"Cell Survival") |
| pubmed:23393546 | a(MESH:"desmethyl-WAY 100635") decreases act(a(CHEBI:pizotifen)) |
| pubmed:23393546 | a(MESH:"desmethyl-WAY 100635") decreases act(p(HGNC:MAPK3)) |
| pubmed:23393546 | a(MESH:"desmethyl-WAY 100635") decreases act(p(HGNC:MAPK1)) |
| pubmed:23393546 | a(MESH:"desmethyl-WAY 100635") increases complex(a(CHEBI:serotonin), p(HGNC:HTR1A)) |
| pubmed:23393546 | complex(a(CHEBI:serotonin), p(HGNC:HTR1A)) decreases act(p(HGNC:MAPK3)) |
| pubmed:23393546 | complex(a(CHEBI:serotonin), p(HGNC:HTR1A)) decreases act(p(HGNC:MAPK1)) |
| pubmed:23393546 | a(DRUGBANK:Robalzotan) decreases p(HGNC:HTR1A) |
| pubmed:23393546 | complex(a(CHEBI:risperidone), p(HGNCGENEFAMILY:"5-hydroxytryptamine receptors, G protein-coupled")) increases act(a(CHEBI:risperidone), ma(GO:"serotonin receptor activity")) |
| pubmed:23393546 | complex(a(CHEBI:metergoline), p(HGNCGENEFAMILY:"5-hydroxytryptamine receptors, G protein-coupled")) increases act(a(CHEBI:metergoline), ma(GO:"serotonin receptor activity")) |
| pubmed:23393546 | complex(a(CHEBI:ketanserin), p(HGNCGENEFAMILY:"5-hydroxytryptamine receptors, G protein-coupled")) increases act(a(CHEBI:ketanserin), ma(GO:"serotonin receptor activity")) |
| pubmed:23393546 | complex(a(CHEBI:spiperone), p(HGNCGENEFAMILY:"5-hydroxytryptamine receptors, G protein-coupled")) increases act(a(CHEBI:spiperone), ma(GO:"serotonin receptor activity")) |
| pubmed:23393546 | complex(a(CHEBI:promethazine), p(HGNCGENEFAMILY:"5-hydroxytryptamine receptors, G protein-coupled")) increases act(a(CHEBI:promethazine), ma(GO:"serotonin receptor activity")) |
| pubmed:23393546 | a(CHEBI:promethazine) increases bp(MESH:"Cell Survival") |
| pubmed:23393546 | a(CHEBI:promethazine) decreases p(HGNC:HRH1) |
| pubmed:23393546 | a(CHEBI:promethazine) decreases path(DOID:"Huntington's disease") |
| pubmed:23393546 | a(CHEBI:cetirizine) decreases p(HGNC:HRH1) |
| pubmed:23393546 | a(CHEBI:cetirizine) causesNoChange bp(MESH:"Cell Survival") |
| pubmed:23393546 | a(CHEBI:diphenhydramine) decreases p(HGNC:HRH1) |
| pubmed:23393546 | a(CHEBI:diphenhydramine) causesNoChange bp(MESH:"Cell Survival") |
| pubmed:23393546 | a(CHEBI:ketotifen) decreases p(HGNC:HRH1) |
| pubmed:23393546 | a(CHEBI:ketotifen) causesNoChange bp(MESH:"Cell Survival") |
| pubmed:23393546 | a(CHEBI:desloratadine) decreases p(HGNC:HRH1) |
| pubmed:23393546 | a(CHEBI:desloratadine) causesNoChange bp(MESH:"Cell Survival") |
| pubmed:23393546 | a(CHEBI:levochlorpheniramine) decreases p(HGNC:HRH1) |
| pubmed:23393546 | a(CHEBI:levochlorpheniramine) causesNoChange bp(MESH:"Cell Survival") |
| pubmed:23393546 | bp(GO:"dopamine receptor signaling pathway") association p(HGNC:PPP1R1B) |
| pubmed:23393546 | bp(GO:"serotonin receptor signaling pathway") association p(HGNC:PPP1R1B) |
| pubmed:23393546 | p(HGNC:GAD2) association path(DOID:"Huntington's disease") |
| pubmed:23393546 | p(HGNC:GAD2) association path(DOID:"Huntington's disease") |
| pubmed:23393546 | p(HGNC:GRIA3) association path(DOID:"Huntington's disease") |
| pubmed:23393546 | p(HGNC:HTR1B) association path(DOID:"Huntington's disease") |
| pubmed:23393546 | p(HGNC:HTR1B) association path(DOID:"Huntington's disease") |
| pubmed:19933700 | p(HGNC:KPNB1) association bp(GO:"nuclear transport") |
| pubmed:19933700 | bp(GO:"nuclear transport") association p(HGNC:KPNB1) |
| pubmed:19933700 | a(CHEBI:Trypsin) increases complex(p(HGNC:HTT, frag("1254_*")), p(HGNC:HTT, frag("1_1184"))) |
| pubmed:19933700 | p(HGNCGENEFAMILY:"Polycomb repressive complex 2") regulates r(HGNC:HOXB1) |
| pubmed:19933700 | p(HGNCGENEFAMILY:"Polycomb repressive complex 2") regulates r(HGNC:HOXB2) |
| pubmed:19933700 | p(HGNCGENEFAMILY:"Polycomb repressive complex 2") regulates r(HGNC:HOXB9) |
| pubmed:19933700 | path(MESH:"Cell Differentiation") increases r(NCBIGENE:2350) |
| pubmed:19933700 | r(NCBIGENE:2350) increases path(MESH:"X Chromosome Inactivation") |
| pubmed:19933700 | p(CONSO:"Histone H3", pmod(mod:00430 ! "trimethylated residue", Lys, 27)) association p(HGNC:HTT) |
| pubmed:19933700 | p(HGNCGENEFAMILY:"Polycomb repressive complex 2", var("?")) increases p(CONSO:"Histone H3", pmod(mod:00430 ! "trimethylated residue", Lys, 27)) |
| pubmed:21861815 | p(MESH:"Hypoxia-Inducible Factor 1") positiveCorrelation a(PUBCHEM:6918822) |
| pubmed:21861815 | act(p(MESH:"Hypoxia-Inducible Factor 1")) increases bp(GO:"cellular response to oxygen-glucose deprivation") |
| pubmed:21861815 | act(p(MESH:"Hypoxia-Inducible Factor 1")) increases bp(GO:"cellular response to oxidative stress") |
| pubmed:21861815 | act(p(MESH:"Hypoxia-Inducible Factor 1")) increases bp(NCIT:C16559) |
| pubmed:21861815 | act(p(MESH:"Hypoxia-Inducible Factor 1")) increases bp(GO:angiogenesis) |
| pubmed:21861815 | act(p(MESH:"Hypoxia-Inducible Factor 1")) decreases a(CHEBI:amyloid-beta) |
| pubmed:21861815 | act(p(MESH:"Hypoxia-Inducible Factor 1")) decreases path(DOID:"Alzheimer's disease") |
| pubmed:21861815 | act(p(MESH:"Hypoxia-Inducible Factor 1")) negativeCorrelation path(DOID:"Parkinson's disease") |
| pubmed:21861815 | p(MESH:"Hypoxia-Inducible Factor 1") decreases path(DOID:"Parkinson's disease") |
| pubmed:21861815 | p(MESH:"Hypoxia-Inducible Factor 1") increases a(CHEBI:dopamine) |
| pubmed:21861815 | p(MESH:"Hypoxia-Inducible Factor 1") increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21861815 | p(MESH:"Hypoxia-Inducible Factor 1") increases a(CHEBI:ATP) |
| pubmed:21861815 | p(MESH:"Hypoxia-Inducible Factor 1") increases a(CHEBI:NADPH) |
| pubmed:21861815 | p(MESH:"Hypoxia-Inducible Factor 1") increases bp(NCIT:C16407) |
| pubmed:21861815 | act(p(MESH:"Hypoxia-Inducible Factor 1")) decreases act(p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) |
| pubmed:21861815 | p(MESH:"Hypoxia-Inducible Factor 1") increases bp(GO:"cell redox homeostasis") |
| pubmed:21861815 | p(MESH:"Hypoxia-Inducible Factor 1") increases p(HGNC:ENO1) |
| pubmed:21861815 | p(MESH:"Hypoxia-Inducible Factor 1") increases p(HGNC:VEGFA) |
| pubmed:21861815 | p(MESH:"Hypoxia-Inducible Factor 1") increases p(HGNC:BDNF) |
| pubmed:21861815 | p(HGNCGENEFAMILY:"Basic helix-loop-helix proteins") increases p(MESH:"Hypoxia-Inducible Factor 1") |
| pubmed:21861815 | p(PFAM:PAS) increases p(MESH:"Hypoxia-Inducible Factor 1") |
| pubmed:21861815 | bp(GO:"response to hypoxia") increases tloc(p(HGNC:HIF1A), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:21861815 | bp(GO:"response to hypoxia") increases act(p(HGNC:RWDD3)) |
| pubmed:21861815 | bp(GO:"response to hypoxia") increases act(p(HGNC:VEGFA)) |
| pubmed:21861815 | bp(GO:"response to hypoxia") increases bp(GO:"cell death") |
| pubmed:21861815 | complex(p(HGNC:ARNT), p(HGNC:HIF1A), loc(GO:nucleus)) increases act(p(MESH:"Hypoxia-Inducible Factor 1")) |
| pubmed:21861815 | complex(p(MESH:"Hypoxia-Inducible Factor 1"), p(NCIT:C13718)) increases p(HGNC:CREBBP) |
| pubmed:21861815 | complex(p(MESH:"Hypoxia-Inducible Factor 1"), p(NCIT:C13718)) increases p(HGNC:EP300) |
| pubmed:21861815 | p(NCIT:C13718) increases p(HGNC:VEGFA) |
| pubmed:21861815 | p(NCIT:C13718) decreases path(DOID:neuropathy) |
| pubmed:21861815 | act(p(NCIT:C13718)) negativeCorrelation path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:21861815 | p(NCIT:C13718) regulates r(HGNC:TH) |
| pubmed:21861815 | p(HGNC:EGLN2) increases p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Pro, 402)) |
| pubmed:21861815 | p(HGNC:EGLN2) increases p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Pro, 546)) |
| pubmed:21861815 | p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Pro, 402)) increases complex(p(HGNC:HIF1A), p(HGNC:VHL)) |
| pubmed:21861815 | p(HGNC:EGLN1) increases p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Pro, 402)) |
| pubmed:21861815 | p(HGNC:EGLN1) increases p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Pro, 546)) |
| pubmed:25036637 | p(HGNC:EGLN1) association p(HGNC:FKBP5) |
| pubmed:25036637 | p(HGNC:EGLN1) association p(INTERPRO:"Zinc finger, MYND-type") |
| pubmed:21861815 | p(HGNC:EGLN3) increases p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Pro, 402)) |
| pubmed:21861815 | p(HGNC:EGLN3) increases p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Pro, 546)) |
| pubmed:21861815 | composite(a(CHEBI:"2-oxoglutarate(1-)"), a(CHEBI:"iron(2+)"), a(CHEBI:dioxygen)) increases act(p(HGNC:EGLN2)) |
| pubmed:21861815 | composite(a(CHEBI:"2-oxoglutarate(1-)"), a(CHEBI:"iron(2+)"), a(CHEBI:dioxygen)) increases act(p(HGNC:EGLN1)) |
| pubmed:21861815 | composite(a(CHEBI:"2-oxoglutarate(1-)"), a(CHEBI:"iron(2+)"), a(CHEBI:dioxygen)) increases act(p(HGNC:EGLN3)) |
| pubmed:21861815 | complex(p(HGNC:HIF1A), p(HGNC:VHL)) increases p(HGNC:HIF1A, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:21861815 | complex(p(HGNC:HIF1A), p(HGNC:VHL)) increases deg(p(HGNC:HIF1A)) |
| pubmed:21861815 | p(HGNC:HIF1A, pmod(go:0016567 ! "protein ubiquitination")) increases composite(p(HGNC:HIF1A, pmod(go:0016567 ! "protein ubiquitination")), p(NCIT:C13970)) |
| pubmed:21861815 | composite(p(HGNC:HIF1A, pmod(go:0016567 ! "protein ubiquitination")), p(NCIT:C13970)) increases deg(p(HGNC:HIF1A)) |
| pubmed:21861815 | a(CHEBI:"iron chelator") decreases p(HGNC:EGLN2) |
| pubmed:21861815 | a(CHEBI:"iron chelator") decreases p(HGNC:EGLN1) |
| pubmed:21861815 | a(CHEBI:"iron chelator") decreases p(HGNC:EGLN3) |
| pubmed:21861815 | a(CHEBI:"iron chelator") increases r(HGNC:HIF1A) |
| pubmed:21861815 | composite(a(CHEBI:dioxygen), p(HGNC:HIF1AN)) increases p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Asn, 803)) |
| pubmed:21861815 | p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Asn, 803)) decreases complex(p(HGNC:CREBBP), p(HGNC:HIF1A)) |
| pubmed:21861815 | p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Asn, 803)) decreases complex(p(HGNC:EP300), p(HGNC:HIF1A)) |
| pubmed:21861815 | p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Asn, 803)) decreases act(p(HGNC:CREBBP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:21861815 | p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Asn, 803)) decreases act(p(HGNC:EP300), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:21861815 | p(HGNC:NAA10) increases p(HGNC:HIF1A, pmod(go:0006473 ! "protein acetylation", Lys, 532)) |
| pubmed:21861815 | p(HGNC:NAA10) increases complex(p(HGNC:HIF1A), p(HGNC:VHL)) |
| pubmed:21861815 | p(HGNC:NAA10) increases deg(p(HGNC:HIF1A)) |
| pubmed:21861815 | p(HGNC:HIF1A, pmod(go:0006473 ! "protein acetylation", Lys, 532)) increases complex(p(HGNC:HIF1A), p(HGNC:VHL)) |
| pubmed:21861815 | p(HGNC:HIF1A, var("p.Lys532?")) increases p(HGNC:HIF1A) |
| pubmed:21861815 | p(HGNC:HIF1A, pmod(go:0006468 ! "protein phosphorylation", Thr, 796)) increases complex(p(HGNC:ARNT), p(HGNC:HIF1A)) |
| pubmed:21861815 | p(HGNC:HIF1A, pmod(go:0006468 ! "protein phosphorylation", Thr, 796)) increases complex(p(HGNC:CREBBP), p(HGNC:HIF1A)) |
| pubmed:21861815 | p(HGNC:HIF1A, pmod(go:0006468 ! "protein phosphorylation", Thr, 796)) increases complex(p(HGNC:EP300), p(HGNC:HIF1A)) |
| pubmed:21861815 | p(HGNC:HIF1A, pmod(go:0006468 ! "protein phosphorylation", Thr, 796)) decreases act(p(HGNC:HIF1AN)) |
| pubmed:21861815 | p(HGNC:HIF1A, pmod(go:0006468 ! "protein phosphorylation", Thr, 796)) decreases p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Asn, 803)) |
| pubmed:21861815 | p(HGNC:HIF1A, pmod(go:0006468 ! "protein phosphorylation", Thr, 796)) increases act(p(HGNC:HIF1A), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:21861815 | p(HGNC:HIF1A, pmod(go:0006468 ! "protein phosphorylation", Thr, 796)) increases tloc(p(HGNC:HIF1A), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:21861815 | act(p(HGNC:HIF1A, pmod(go:0006468 ! "protein phosphorylation")), ma(GO:"proteasome binding")) increases deg(p(HGNC:HIF1A)) |
| pubmed:21861815 | a(CHEBI:hydroxyl) decreases p(HGNC:HIF1A) |
| pubmed:21861815 | p(HGNC:HIF1A, pmod(NCIT:C16944)) increases complex(a(NCIT:C13737), p(HGNC:HIF1A)) |
| pubmed:21861815 | complex(a(NCIT:C13737), p(HGNC:HIF1A)) increases deg(p(HGNC:HIF1A)) |
| pubmed:21861815 | p(HGNC:HIF1A, pmod(go:0017014 ! "protein nitrosylation")) increases p(HGNC:HIF1A) |
| pubmed:21861815 | p(HGNC:HIF1A, pmod(go:0017014 ! "protein nitrosylation", Cys, 800)) increases complex(p(HGNC:CREBBP), p(HGNC:HIF1A)) |
| pubmed:21861815 | p(HGNC:HIF1A, pmod(go:0017014 ! "protein nitrosylation", Cys, 800)) increases complex(p(HGNC:EP300), p(HGNC:HIF1A)) |
| pubmed:21861815 | p(HGNC:HIF1A, pmod(go:0017014 ! "protein nitrosylation", Cys, 800)) increases act(p(HGNC:HIF1A)) |
| pubmed:21861815 | p(HGNC:HIF1A, pmod(go:0016925 ! "protein sumoylation")) regulates r(HGNC:HIF1A) |
| pubmed:21861815 | p(HGNC:HIF1A, pmod(go:0016925 ! "protein sumoylation")) regulates act(p(HGNC:HIF1A), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:21861815 | p(HGNC:HIF1A, pmod(go:0016925 ! "protein sumoylation")) increases p(HGNC:HIF1A) |
| pubmed:21861815 | act(p(HGNC:RWDD3)) increases act(p(HGNC:UBE2I)) |
| pubmed:21861815 | p(HGNC:UBE2I) increases p(HGNC:HIF1A, pmod(go:0016925 ! "protein sumoylation")) |
| pubmed:19323834 | p(HGNC:UBE2I) directlyDecreases r(HGNC:NOS2) |
| pubmed:18675254 | p(HGNC:UBE2I) association complex(GO:"endoplasmic reticulum") |
| pubmed:21861815 | p(HGNCGENEFAMILY:"SUMO specific peptidases") decreases p(HGNC:HIF1A, pmod(go:0016925 ! "protein sumoylation")) |
| pubmed:21861815 | p(HGNCGENEFAMILY:"SUMO specific peptidases") regulates p(HGNC:HIF1A) |
| pubmed:21861815 | path(DOID:hypoglycemia) negativeCorrelation bp(GO:"energy homeostasis") |
| pubmed:21861815 | path(DOID:hypoglycemia) increases bp(GO:"neuron death") |
| pubmed:21861815 | path(EFO:hypoxemia) negativeCorrelation p(HGNC:VEGFA) |
| pubmed:21861815 | composite(p(HGNC:SOD1, var("Gly93Ala")), p(NCIT:C13718)) decreases bp(GO:"neuron death") |
| pubmed:21861815 | composite(p(HGNC:SOD1, var("Gly93Ala")), p(NCIT:C13718)) decreases path(MESH:"Motor Disorders") |
| pubmed:21861815 | p(HGNC:SOD1, var("Gly93Ala")) increases p(HGNC:EPO) |
| pubmed:21861815 | complex(p(HGNC:NRP1), p(HGNC:VEGFA)) decreases bp(GO:"cell death") |
| pubmed:21861815 | p(HGNC:NRP1) association bp(GO:"axon guidance") |
| pubmed:21861815 | composite(p(HGNC:EPO), p(HGNC:SOD1, var("Gly93Ala"))) decreases path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:21861815 | composite(p(HGNC:EPO), p(HGNC:SOD1, var("Gly93Ala"))) decreases bp(GO:"neuron death") |
| pubmed:21861815 | composite(p(HGNC:EPO), p(HGNC:SOD1, var("Gly93Ala"))) decreases bp(GO:"inflammatory response") |
| pubmed:21861815 | a(PUBCHEM:6918822) positiveCorrelation p(MESH:"Hypoxia-Inducible Factor 1") |
| pubmed:21861815 | a(PUBCHEM:6918822) decreases bp(GO:"neuron death in response to oxidative stress") |
| pubmed:21861815 | a(PUBCHEM:6918822) increases r(HGNC:HIF1A) |
| pubmed:21861815 | a(PUBCHEM:6918822) increases r(HGNC:EPO) |
| pubmed:21861815 | a(PUBCHEM:6918822) increases r(HGNC:VEGFA) |
| pubmed:21861815 | a(PUBCHEM:6918822) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21861815 | a(PUBCHEM:6918822) decreases path(MESH:"Amyloid Neuropathies") |
| pubmed:21861815 | a(PUBCHEM:6918822) increases p(HGNC:ENO1) |
| pubmed:21861815 | a(PUBCHEM:6918822) increases p(HGNC:VEGFA) |
| pubmed:21861815 | a(PUBCHEM:6918822) increases p(HGNC:BDNF) |
| pubmed:21861815 | composite(a(PUBCHEM:6918822), p(HGNC:SOD1, var("Gly93Ala"))) decreases path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:21861815 | a(PUBCHEM:2973) increases p(MESH:"Hypoxia-Inducible Factor 1") |
| pubmed:21861815 | a(PUBCHEM:2973) increases act(p(MESH:"Hypoxia-Inducible Factor 1")) |
| pubmed:21861815 | a(PUBCHEM:2973) decreases bp(GO:cognition) |
| pubmed:21861815 | a(PUBCHEM:2973) decreases path(DOID:"Alzheimer's disease") |
| pubmed:21861815 | a(PUBCHEM:2973) increases r(HGNC:TH) |
| pubmed:21861815 | a(PUBCHEM:2973) decreases path(MESH:"Neurotoxicity Syndromes") |
| pubmed:21861815 | a(PUBCHEM:2973) decreases path(DOID:"neurodegenerative disease") |
| pubmed:21861815 | a(PUBCHEM:2973) negativeCorrelation path(NCIT:C27988) |
| pubmed:21861815 | a(PUBCHEM:2973) decreases path(NCIT:C27988) |
| pubmed:30562574 | bp(GO:"cellular response to oxidative stress") increases bp(GO:"chaperone-mediated autophagy") |
| pubmed:21861815 | p(HGNC:SLC2A3) regulates bp(GO:"glucose import") |
| pubmed:21861815 | a(CHEBI:"1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine") decreases p(HGNC:HIF1A) |
| pubmed:21861815 | a(CHEBI:"1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine") increases bp(GO:"cell death") |
| pubmed:21861815 | a(CHEBI:"1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine") increases path(MESH:"Neurotoxicity Syndromes") |
| pubmed:21861815 | a(PUBCHEM:137275695) increases act(p(MESH:"Hypoxia-Inducible Factor 1")) |
| pubmed:21861815 | a(PUBCHEM:137275695) increases a(CHEBI:dopamine, loc(GO:"extracellular region")) |
| pubmed:21861815 | a(CHEBI:"cobalt dichloride") increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:21861815 | a(CHEBI:"cobalt dichloride") increases p(MESH:"Hypoxia-Inducible Factor 1") |
| pubmed:21861815 | a(CHEBI:"cobalt dichloride") negativeCorrelation path(NCIT:C27988) |
| pubmed:21861815 | a(CHEBI:"cobalt dichloride") increases path(MESH:Cytoprotection) |
| pubmed:21861815 | a(CHEBI:"3,4-dihydroxybenzoate") increases p(HGNC:HIF1A) |
| pubmed:21861815 | a(CHEBI:"3,4-dihydroxybenzoate") increases g(HGNC:SLC40A1) |
| pubmed:21861815 | a(CHEBI:"3,4-dihydroxybenzoate") increases g(HGNC:HMOX1) |
| pubmed:21861815 | a(CHEBI:"3,4-dihydroxybenzoate") increases g(HGNC:SOD1) |
| pubmed:21861815 | a(CHEBI:5-chloro-7-iodoquinolin-8-ol) increases p(HGNC:HIF1A) |
| pubmed:21861815 | a(CHEBI:5-chloro-7-iodoquinolin-8-ol) decreases bp(GO:"cell death") |
| pubmed:21861815 | a(CHEBI:5-chloro-7-iodoquinolin-8-ol) decreases a(CONSO:"huntingtin aggregates") |
| pubmed:21861815 | a(CHEBI:5-chloro-7-iodoquinolin-8-ol) decreases path(HP:"Behavioral abnormality") |
| pubmed:21861815 | a(CHEBI:5-chloro-7-iodoquinolin-8-ol) increases path(EFO:"physical activity") |
| pubmed:30116051 | a(CHEBI:5-chloro-7-iodoquinolin-8-ol) increases bp(GO:macroautophagy) |
| pubmed:30116051 | a(CHEBI:5-chloro-7-iodoquinolin-8-ol) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:30116051 | a(CHEBI:5-chloro-7-iodoquinolin-8-ol) decreases a(CONSO:"amyloid-beta aggregates") |
| pubmed:21861815 | a(CHEBI:oxidopamine) increases path(DOID:"neurodegenerative disease") |
| pubmed:21722302 | a(CHEBI:oxidopamine) increases path(MESH:"Parkinson Disease") |
| pubmed:21861815 | path(NCIT:C27988) negativeCorrelation a(CHEBI:"cobalt dichloride") |
| pubmed:21861815 | path(NCIT:C27988) negativeCorrelation a(CHEBI:L-mimosine) |
| pubmed:21861815 | path(NCIT:C27988) negativeCorrelation a(PUBCHEM:2973) |
| pubmed:21861815 | a(CHEBI:L-mimosine) negativeCorrelation path(NCIT:C27988) |
| pubmed:21861815 | a(CHEBI:"3-nitropropanoic acid") increases path(NCIT:C27988) |
| pubmed:21861815 | p(MESH:"Prolyl Hydroxylases") increases deg(p(HGNC:HIF1A)) |
| pubmed:21861815 | p(MESH:"Prolyl Hydroxylases") increases path(DOID:"neurodegenerative disease") |
| pubmed:21861815 | p(HGNC:ASPH) decreases act(p(HGNC:HIF1A)) |
| pubmed:21861815 | p(HGNC:ASPH) increases path(DOID:"neurodegenerative disease") |
| pubmed:21861815 | composite(a(CHEBI:"iron chelator"), a(CHEBI:"iron(2+)")) decreases a(CHEBI:hydroxyl) |
| pubmed:21861815 | composite(a(CHEBI:"iron(2+)"), a(PUBCHEM:2973)) increases act(p(MESH:"Hypoxia-Inducible Factor 1")) |
| pubmed:21861815 | composite(a(PUBCHEM:3052776), a(PUBCHEM:6918822)) decreases path(DOID:"Parkinson's disease") |
| pubmed:21861815 | composite(a(PUBCHEM:3052776), a(PUBCHEM:6918819)) decreases path(DOID:"Parkinson's disease") |
| pubmed:21861815 | a(PUBCHEM:6918819) increases p(HGNC:ENO1) |
| pubmed:21861815 | a(PUBCHEM:6918819) increases p(HGNC:VEGFA) |
| pubmed:21861815 | a(PUBCHEM:6918819) increases p(HGNC:BDNF) |
| pubmed:28148553 | p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation a(CHEBI:thapsigargin) |
| pubmed:21722302 | p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) increases bp(CONSO:"protein aggregation") |
| pubmed:30740335 | p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) increases p(HGNC:ATF4) |
| pubmed:28148553 | p(HGNC:EIF2AK3) association p(HGNC:NFE2L2) |
| pubmed:28148553 | p(HGNC:EIF2AK3) decreases p(CONSO:"4R tau") |
| pubmed:28148553 | p(HGNC:EIF2AK3) decreases composite(a(PUBCHEM:3108148), p(CONSO:"4R tau")) |
| pubmed:21722302 | act(p(HGNC:EIF2AK3)) association bp(MESH:"Unfolded Protein Response") |
| pubmed:21722302 | p(HGNC:EIF2AK3) increases p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 51)) |
| pubmed:21722302 | p(HGNC:EIF2AK3) decreases complex(p(HGNC:KEAP1), p(HGNC:NFE2L2)) |
| pubmed:21722302 | p(HGNC:EIF2AK3) increases p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation"), loc(MESH:"Cell Nucleus")) |
| pubmed:21722302 | p(HGNC:EIF2AK3) regulates bp(GO:autophagy) |
| pubmed:21722302 | p(HGNC:EIF2AK3) increases bp(GO:autophagy) |
| pubmed:21722302 | p(HGNC:EIF2AK3) increases p(HGNC:ATG12) |
| pubmed:21722302 | p(HGNC:EIF2AK3) increases p(HGNC:DDIT3) |
| pubmed:21722302 | p(HGNC:EIF2AK3) increases p(HGNC:ATF4) |
| pubmed:21722302 | p(HGNC:EIF2AK3) association p(PFAM:Presenilin) |
| pubmed:30606258 | act(p(HGNC:EIF2AK3)) increases bp(GO:"PERK-mediated unfolded protein response") |
| pubmed:30606258 | act(p(HGNC:EIF2AK3)) increases p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30740335 | p(HGNC:EIF2AK3) increases p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30740335 | act(p(HGNC:EIF2AK3)) increases p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30740335 | p(HGNC:EIF2AK3) increases p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30740335 | p(HGNC:EIF2AK3) increases p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25784053 | act(p(HGNC:EIF2AK3)) increases p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30740335 | p(HGNC:EIF2AK3) regulates path(MESH:"Unfolded Protein Response") |
| pubmed:30740335 | p(HGNC:EIF2AK3) decreases bp(GO:"synaptic signaling") |
| pubmed:30740335 | p(HGNC:EIF2AK3) association bp(GO:"negative regulation of dopamine receptor signaling pathway") |
| pubmed:27299292 | p(HGNC:EIF2AK3) association bp(GO:"response to endoplasmic reticulum stress") |
| pubmed:27299292 | p(HGNC:EIF2AK3) association act(p(HGNC:TFEB)) |
| pubmed:27299292 | p(HGNC:EIF2AK3) association p(HGNC:PPP3CA) |
| pubmed:21722302 | p(HGNC:EIF2A) increases p(HGNC:NUPR1) |
| pubmed:21722302 | p(HGNC:EIF2A) increases p(HGNC:ATF4) |
| pubmed:21722302 | p(HGNC:EIF2A) increases p(HGNC:DDIT3) |
| pubmed:21722302 | p(HGNC:EIF2A) increases p(HGNC:TRIB3) |
| pubmed:24563850 | p(HGNC:EIF2A) association p(HGNC:HSPB8) |
| pubmed:28148553 | p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation a(CHEBI:thapsigargin) |
| pubmed:21722302 | p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) increases bp(CONSO:"protein aggregation") |
| pubmed:27181519 | p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) increases complex(GO:"cytoplasmic stress granule") |
| pubmed:27181519 | p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) decreases bp(GO:translation) |
| pubmed:28148553 | bp(MESH:"Unfolded Protein Response") association p(HGNC:MAPT) |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") decreases bp(GO:translation) |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") decreases bp(GO:"mRNA transcription") |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") increases p(MESH:"Molecular Chaperones") |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") increases deg(p(MESH:Proteins, pmod(CONSO:misfolded))) |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") association act(p(HGNC:ERN1)) |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") association act(p(HGNC:EIF2AK3)) |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") association act(p(HGNC:ATF6)) |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") increases act(p(HGNC:ATF6)) |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") increases act(p(HGNC:ATF4)) |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") increases act(p(HGNC:ATF3)) |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") increases act(p(HGNC:NFE2L2)) |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") increases act(p(HGNC:XBP1)) |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") increases bp(GO:"apoptotic signaling pathway") |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") increases p(HGNC:DDIT3) |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") increases p(HGNC:DDIT3) |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") increases bp(GO:autophagy) |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") increases bp(GO:autophagy) |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") increases p(HGNC:HSPA5) |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") increases p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") increases bp(MESH:Apoptosis) |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") increases bp(MESH:Apoptosis) |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") increases bp(MESH:Apoptosis) |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") increases bp(GO:mitophagy) |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") association p(HGNC:VAPB) |
| pubmed:21722302 | bp(MESH:"Unfolded Protein Response") association path(MESH:"Neurodegenerative Diseases") |
| pubmed:30740335 | bp(MESH:"Unfolded Protein Response") increases deg(p(MESH:"Mutant Proteins")) |
| pubmed:28148553 | a(PUBCHEM:354398) association path(DOID:tauopathy) |
| pubmed:28148553 | a(PUBCHEM:354398) increases p(HGNC:MAPT) |
| pubmed:28148553 | a(PUBCHEM:354398) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:28148553 | a(PUBCHEM:354398) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation), loc(GO:"somatodendritic compartment")) |
| pubmed:28148553 | a(PUBCHEM:354398) increases bp(GO:"cell death") |
| pubmed:28148553 | a(PUBCHEM:354398) increases act(p(HGNCGENEFAMILY:"Mitochondrial complex I assembly complex")) |
| pubmed:28148553 | a(PUBCHEM:354398) increases p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | a(PUBCHEM:354398) decreases p(HGNC:EIF2AK3) |
| pubmed:28148553 | a(PUBCHEM:354398) decreases p(HGNC:EIF2A) |
| pubmed:28148553 | a(PUBCHEM:354398) decreases a(CHEBI:"3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide") |
| pubmed:28148553 | a(PUBCHEM:354398) decreases a(CHEBI:ATP) |
| pubmed:28148553 | a(PUBCHEM:354398) increases a(CONSO:"Tau antibody, MC1") |
| pubmed:28148553 | a(PUBCHEM:354398) increases p(CONSO:"Tau epitope, CP13") |
| pubmed:28148553 | a(PUBCHEM:354398) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:28148553 | a(PUBCHEM:354398) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:28148553 | a(PUBCHEM:354398) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:28148553 | a(PUBCHEM:354398) increases p(CONSO:"Tau epitope, AD2") |
| pubmed:28148553 | a(PUBCHEM:354398) causesNoChange a(CONSO:"Tau antibody, HT7") |
| pubmed:28148553 | a(PUBCHEM:354398) increases p(CONSO:"4R tau") |
| pubmed:28148553 | a(PUBCHEM:354398) causesNoChange p(CONSO:"3R tau") |
| pubmed:28148553 | a(PUBCHEM:354398) increases r(HGNC:SRSF2) |
| pubmed:28148553 | a(PUBCHEM:354398) decreases p(HGNC:NEFM, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | a(PUBCHEM:354398) increases path(DOID:"axonal neuropathy") |
| pubmed:26631930 | a(PUBCHEM:354398) decreases act(complex(GO:"mitochondrial respiratory chain complex I")) |
| pubmed:28148553 | act(p(HGNCGENEFAMILY:"Mitochondrial complex I assembly complex")) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation), loc(GO:"somatodendritic compartment")) |
| pubmed:28148553 | p(UNIPROT:"X5DSL3 (X5DSL3_ANAMA)") causesNoChange p(HGNC:EIF2AK3) |
| pubmed:28148553 | p(UNIPROT:"X5DSL3 (X5DSL3_ANAMA)") causesNoChange p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | p(UNIPROT:"X5DSL3 (X5DSL3_ANAMA)") causesNoChange p(HGNC:EIF2A) |
| pubmed:28148553 | a(PUBCHEM:3108148) increases p(HGNC:EIF2AK3) |
| pubmed:28148553 | a(PUBCHEM:3108148) decreases composite(a(PUBCHEM:354398), p(CONSO:"4R tau")) |
| pubmed:28148553 | a(PUBCHEM:3108148) increases bp(GO:"chromatin organization") |
| pubmed:28148553 | a(PUBCHEM:3108148) decreases path(MESH:"Neuronal Plasticity") |
| pubmed:28148553 | a(PUBCHEM:3108148) increases r(HGNC:HMOX1) |
| pubmed:28148553 | a(PUBCHEM:3108148) increases composite(a(PUBCHEM:3108148), p(HGNC:NFE2L2)) |
| pubmed:28148553 | a(PUBCHEM:3108148) decreases a(CONSO:"Tau antibody, MC1") |
| pubmed:28148553 | a(PUBCHEM:3108148) decreases p(CONSO:"Tau epitope, CP13") |
| pubmed:28148553 | a(PUBCHEM:3108148) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:28148553 | a(PUBCHEM:3108148) decreases p(CONSO:"Tau epitope, AD2") |
| pubmed:28148553 | a(PUBCHEM:3108148) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:28148553 | a(PUBCHEM:3108148) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:28148553 | a(PUBCHEM:3108148) causesNoChange a(CONSO:"Tau antibody, HT7") |
| pubmed:28148553 | a(PUBCHEM:3108148) decreases p(CONSO:"4R tau") |
| pubmed:28148553 | a(PUBCHEM:3108148) directlyDecreases r(HGNC:SRSF2) |
| pubmed:28148553 | a(PUBCHEM:3108148) increases p(HGNC:NEFM, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | a(PUBCHEM:3108148) decreases path(DOID:"axonal neuropathy") |
| pubmed:28148553 | composite(a(PUBCHEM:3108148), a(PUBCHEM:354398)) increases p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | composite(a(PUBCHEM:3108148), a(PUBCHEM:354398)) causesNoChange p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | composite(a(PUBCHEM:3108148), a(PUBCHEM:354398)) increases a(CHEBI:"3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide") |
| pubmed:28148553 | composite(a(PUBCHEM:3108148), a(PUBCHEM:354398)) increases a(CHEBI:ATP) |
| pubmed:28148553 | composite(a(PUBCHEM:3108148), a(PUBCHEM:354398)) increases bp(GO:"metabolic process") |
| pubmed:28148553 | a(PUBCHEM:53469448) decreases p(HGNC:EIF2AK3) |
| pubmed:28148553 | composite(a(PUBCHEM:354398), a(PUBCHEM:53469448)) decreases p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | composite(a(PUBCHEM:354398), a(PUBCHEM:53469448)) causesNoChange a(CHEBI:"3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide") |
| pubmed:28148553 | composite(a(PUBCHEM:354398), a(PUBCHEM:53469448)) increases a(CHEBI:ATP) |
| pubmed:28148553 | composite(a(PUBCHEM:3108148), p(CONSO:"4R tau")) increases p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | composite(a(PUBCHEM:3108148), p(CONSO:"4R tau")) causesNoChange p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | composite(a(PUBCHEM:53469448), p(CONSO:"4R tau")) decreases p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | composite(a(PUBCHEM:53469448), p(CONSO:"4R tau")) causesNoChange p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | composite(a(PUBCHEM:3108148), p(CONSO:"3R tau")) causesNoChange p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | composite(a(PUBCHEM:3108148), p(CONSO:"3R tau")) causesNoChange p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | composite(a(PUBCHEM:53469448), p(CONSO:"3R tau")) causesNoChange p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | composite(a(PUBCHEM:53469448), p(CONSO:"3R tau")) causesNoChange p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | a(CHEBI:"3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide") association bp(GO:"metabolic process") |
| pubmed:28148553 | composite(a(CHEBI:"3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide"), a(PUBCHEM:3108148)) decreases path(CONSO:"4R tauopathy") |
| pubmed:28148553 | composite(a(CHEBI:ATP), a(PUBCHEM:3108148)) decreases path(CONSO:"4R tauopathy") |
| pubmed:28148553 | composite(a(CHEBI:ATP), a(PUBCHEM:53469448)) decreases path(CONSO:"4R tauopathy") |
| pubmed:28148553 | composite(a(PUBCHEM:354398), p(CONSO:"4R tau")) negativeCorrelation bp(GO:"chromatin organization") |
| pubmed:28148553 | composite(a(PUBCHEM:354398), p(CONSO:"4R tau")) increases path(MESH:"Neuronal Plasticity") |
| pubmed:28148553 | bp(GO:"chromatin organization") negativeCorrelation composite(a(PUBCHEM:354398), p(CONSO:"4R tau")) |
| pubmed:28148553 | a(PUBCHEM:71772353) increases p(HGNC:NFE2L2) |
| pubmed:28148553 | a(PUBCHEM:71772353) decreases path(CONSO:"4R tauopathy") |
| pubmed:25331948 | p(CONSO:"Tau epitope, CP13") equivalentTo p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:28148553 | composite(a(PUBCHEM:3108148), p(CONSO:"Tau isoform F (441 aa)")) decreases p(CONSO:"Tau epitope, CP13") |
| pubmed:28148553 | composite(a(PUBCHEM:3108148), p(CONSO:"Tau isoform F (441 aa)")) causesNoChange p(CONSO:"Tau epitope, AD2") |
| pubmed:28148553 | composite(a(PUBCHEM:3108148), p(CONSO:"Tau isoform F (441 aa)")) causesNoChange a(CONSO:"Tau antibody, HT7") |
| pubmed:28148553 | p(HGNC:NEFM, pmod(go:0006468 ! "protein phosphorylation")) regulates act(a(MESH:Axons)) |
| pubmed:28148553 | p(HGNC:NEFM, pmod(go:0006468 ! "protein phosphorylation")) decreases path(DOID:"axonal neuropathy") |
| pubmed:28148553 | path(MESH:"Protein Conformation") negativeCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) |
| pubmed:23384725 | path(MESH:"Protein Conformation") negativeCorrelation p(HGNC:TARDBP, frag("101_191"), pmod(GO:"protein oxidation", Cys, 173)) |
| pubmed:23384725 | path(MESH:"Protein Conformation") association p(HGNC:TARDBP, frag("101_191"), pmod(GO:"protein oxidation", Cys, 175)) |
| pubmed:28148553 | bp(GO:"dendritic spine maintenance") negativeCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) |
| pubmed:28148553 | path(MESH:Locomotion) negativeCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) |
| pubmed:28148553 | a(FMA:83664) negativeCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) |
| pubmed:28148553 | composite(a(PUBCHEM:3108148), p(HGNC:MAPT, var("p.Pro301Ser"))) increases p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | composite(a(PUBCHEM:3108148), p(HGNC:MAPT, var("p.Pro301Ser"))) increases p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28148553 | composite(a(PUBCHEM:3108148), p(HGNC:MAPT, var("p.Pro301Ser"))) decreases a(CONSO:"Tau antibody, HT7") |
| pubmed:28148553 | composite(a(PUBCHEM:3108148), p(HGNC:MAPT, var("p.Pro301Ser"))) decreases a(CONSO:"Tau antibody, MC1") |
| pubmed:28148553 | composite(a(PUBCHEM:3108148), p(HGNC:MAPT, var("p.Pro301Ser"))) decreases p(CONSO:"Tau epitope, CP13") |
| pubmed:28148553 | composite(a(PUBCHEM:3108148), p(HGNC:MAPT, var("p.Pro301Ser"))) decreases p(CONSO:"Tau epitope, AT180") |
| pubmed:28148553 | composite(a(PUBCHEM:3108148), p(HGNC:MAPT, var("p.Pro301Ser"))) increases bp(GO:"learning or memory") |
| pubmed:28148553 | composite(a(PUBCHEM:3108148), p(HGNC:MAPT, var("p.Pro301Ser"))) increases bp(GO:"dendritic spine maintenance") |
| pubmed:28148553 | composite(a(PUBCHEM:3108148), p(HGNC:MAPT, var("p.Pro301Ser"))) increases a(OMIT:0023601) |
| pubmed:28148553 | composite(a(PUBCHEM:3108148), p(HGNC:MAPT, var("p.Pro301Ser"))) positiveCorrelation a(MESH:"Spinal Cord Ventral Horn") |
| pubmed:22833681 | p(CONSO:"Tau epitope, AT180") equivalentTo p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:28148553 | composite(a(PUBCHEM:5234), p(HGNC:MAPT)) increases bp(GO:"learning or memory") |
| pubmed:28148553 | composite(a(PUBCHEM:5234), p(HGNC:MAPT)) increases a(OMIT:0023601) |
| pubmed:28148553 | composite(a(PUBCHEM:3108148), p(HGNC:MAPT)) causesNoChange bp(GO:"dendritic spine maintenance") |
| pubmed:28148553 | composite(a(PUBCHEM:5234), p(HGNC:MAPT, var("p.Pro301Ser"))) decreases a(OMIT:0023601) |
| pubmed:28148553 | a(MESH:"Spinal Cord Ventral Horn") negativeCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) |
| pubmed:28148553 | a(MESH:"Spinal Cord Ventral Horn") positiveCorrelation composite(a(PUBCHEM:3108148), p(HGNC:MAPT, var("p.Pro301Ser"))) |
| pubmed:21722302 | path(MESH:"Prion Diseases") association path(CONSO:Neurodegeneration) |
| pubmed:30740335 | path(MESH:"Prion Diseases") increases p(HGNC:EIF2AK3) |
| pubmed:30740335 | path(MESH:"Prion Diseases") increases path(MESH:"Unfolded Protein Response") |
| pubmed:14556719 | path(MESH:"Prion Diseases") increases path(MESH:"Motor Disorders") |
| pubmed:14556719 | path(MESH:"Prion Diseases") increases path(MESH:Dementia) |
| pubmed:14556719 | path(MESH:"Prion Diseases") increases path(MESH:Death) |
| pubmed:14556719 | path(MESH:"Prion Diseases") increases bp(GO:"neuron death") |
| pubmed:14556719 | path(MESH:"Prion Diseases") increases path(MESH:Gliosis) |
| pubmed:14556719 | path(MESH:"Prion Diseases") increases a(CONSO:"amyloid-beta aggregates") |
| pubmed:14556719 | path(MESH:"Prion Diseases") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:14556719 | path(MESH:"Prion Diseases") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:29980653 | path(MESH:"Prion Diseases") isA path(MESH:"Neurodegenerative Diseases") |
| pubmed:29980653 | path(MESH:"Prion Diseases") positiveCorrelation p(HGNC:PRNP, var("?")) |
| pubmed:21722302 | bp(MESH:"Endoplasmic Reticulum Stress") increases path(CONSO:Neurodegeneration) |
| pubmed:21722302 | bp(MESH:"Endoplasmic Reticulum Stress") association p(MESH:Proteins, pmod(CONSO:misfolded)) |
| pubmed:21722302 | bp(MESH:"Endoplasmic Reticulum Stress") increases bp(MESH:"Unfolded Protein Response") |
| pubmed:21722302 | bp(MESH:"Endoplasmic Reticulum Stress") increases p(HGNC:ERN1) |
| pubmed:21722302 | bp(MESH:"Endoplasmic Reticulum Stress") increases p(HGNC:EIF2AK3) |
| pubmed:25784053 | bp(MESH:"Endoplasmic Reticulum Stress") increases p(HGNC:EIF2AK3) |
| pubmed:21722302 | bp(MESH:"Endoplasmic Reticulum Stress") increases p(HGNC:ATF6) |
| pubmed:21722302 | bp(MESH:"Endoplasmic Reticulum Stress") increases tloc(p(HGNC:ATF6), fromLoc(GO:"endoplasmic reticulum membrane"), toLoc(GO:"Golgi apparatus")) |
| pubmed:25784053 | bp(MESH:"Endoplasmic Reticulum Stress") increases tloc(p(HGNC:ATF6), fromLoc(MESH:"Endoplasmic Reticulum"), toLoc(MESH:"Golgi Apparatus")) |
| pubmed:21722302 | bp(MESH:"Endoplasmic Reticulum Stress") increases p(HGNC:ERN1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21722302 | bp(MESH:"Endoplasmic Reticulum Stress") decreases complex(p(HGNC:ATF6), p(HGNC:HSPA5)) |
| pubmed:21722302 | bp(MESH:"Endoplasmic Reticulum Stress") increases p(HGNC:CASP4) |
| pubmed:21722302 | bp(MESH:"Endoplasmic Reticulum Stress") increases p(HGNC:CASP2) |
| pubmed:21722302 | bp(MESH:"Endoplasmic Reticulum Stress") association p(HGNC:BCL2) |
| pubmed:21722302 | bp(MESH:"Endoplasmic Reticulum Stress") decreases p(HGNC:BCL2) |
| pubmed:21722302 | bp(MESH:"Endoplasmic Reticulum Stress") increases complex(GO:"BIM-BCL-2 complex") |
| pubmed:21722302 | bp(MESH:"Endoplasmic Reticulum Stress") increases complex(GO:"PUMA-BCL-2 complex") |
| pubmed:21722302 | bp(MESH:"Endoplasmic Reticulum Stress") increases complex(GO:"NOXA-BCL-2 complex") |
| pubmed:21722302 | bp(MESH:"Endoplasmic Reticulum Stress") increases p(HGNC:DDIT3) |
| pubmed:21722302 | bp(MESH:"Endoplasmic Reticulum Stress") increases act(p(HGNC:PRKAA1)) |
| pubmed:21722302 | bp(MESH:"Endoplasmic Reticulum Stress") increases tloc(a(CHEBI:"calcium cation"), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:cytoplasm)) |
| pubmed:21722302 | bp(MESH:"Endoplasmic Reticulum Stress") increases bp(GO:autophagy) |
| pubmed:21722302 | bp(MESH:"Endoplasmic Reticulum Stress") association path(MESH:"Neurodegenerative Diseases") |
| pubmed:21722302 | bp(MESH:"Endoplasmic Reticulum Stress") decreases r(HGNC:HSPA5) |
| pubmed:21722302 | bp(MESH:"Endoplasmic Reticulum Stress") increases p(HGNC:ATF4) |
| pubmed:21722302 | p(MESH:"Molecular Chaperones") increases bp(GO:"protein folding") |
| pubmed:21722302 | p(MESH:"Molecular Chaperones") increases bp(GO:"protein folding") |
| pubmed:25784053 | bp(GO:"protein folding") association bp(CONSO:Proteostasis) |
| pubmed:29311797 | bp(GO:"protein folding") association a(MESH:"Molecular Chaperones") |
| pubmed:21722302 | act(p(HGNC:ERN1)) association bp(MESH:"Unfolded Protein Response") |
| pubmed:25784053 | act(p(HGNC:ERN1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:ERN1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21722302 | p(HGNC:ERN1) regulates bp(GO:autophagy) |
| pubmed:21722302 | p(HGNC:ERN1) increases bp(GO:"JNK cascade") |
| pubmed:21722302 | p(HGNC:ERN1) association p(PFAM:Presenilin) |
| pubmed:21722302 | p(HGNC:ERN1) regulates p(HGNC:XBP1) |
| pubmed:25784053 | act(p(HGNC:ERN1), ma(GO:"ribonuclease activity")) increases p(HGNC:XBP1) |
| pubmed:21722302 | p(HGNC:ERN1) association p(HGNC:VAPB) |
| pubmed:30606258 | act(p(HGNC:ERN1)) increases bp(GO:"IRE1-mediated unfolded protein response") |
| pubmed:30740335 | p(HGNC:ERN1) regulates path(MESH:"Unfolded Protein Response") |
| pubmed:30740335 | p(HGNC:ERN1) increases p(HGNC:XBP1, frag("?")) |
| pubmed:30740335 | p(HGNC:ERN1) increases p(HGNC:XBP1, frag("?")) |
| pubmed:30740335 | p(HGNC:ERN1) increases deg(p(HGNC:HTT, pmod(HBP:misfolded))) |
| pubmed:21722302 | act(p(HGNC:ATF6)) association bp(MESH:"Unfolded Protein Response") |
| pubmed:21722302 | p(HGNC:ATF6) increases a(MESH:"Molecular Chaperones") |
| pubmed:21722302 | p(HGNC:ATF6) increases a(MESH:"Molecular Chaperones") |
| pubmed:21722302 | p(HGNC:ATF6) increases bp(GO:"ERAD pathway") |
| pubmed:30740335 | p(HGNC:ATF6) association bp(GO:"ERAD pathway") |
| pubmed:21722302 | p(HGNC:ATF6) association p(HGNC:VAPB) |
| pubmed:21722302 | act(p(HGNC:ATF6)) increases r(HGNC:XBP1) |
| pubmed:30740335 | p(HGNC:ATF6) increases r(HGNC:XBP1) |
| pubmed:30740335 | p(HGNC:ATF6) regulates path(MESH:"Unfolded Protein Response") |
| pubmed:30740335 | act(p(HGNC:ATF6)) increases tloc(p(HGNC:ATF6), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:"Golgi apparatus")) |
| pubmed:30740335 | p(HGNC:ATF6) increases p(HGNC:XBP1) |
| pubmed:30740335 | p(HGNC:ATF6) increases p(HGNC:HSPA5) |
| pubmed:30740335 | p(HGNC:ATF6) increases path(MESH:Organogenesis) |
| pubmed:30740335 | p(HGNC:ATF6) increases bp(GO:"mitochondrial unfolded protein response") |
| pubmed:25784053 | p(HGNC:ATF6) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:25784053 | p(HGNC:ATF6) negativeCorrelation path(MESH:"Huntington Disease") |
| pubmed:21722302 | complex(p(HGNC:ERN1), p(HGNC:HSPA5)) decreases act(p(HGNC:ERN1)) |
| pubmed:21722302 | complex(p(HGNC:EIF2AK3), p(HGNC:HSPA5)) decreases act(p(HGNC:EIF2AK3)) |
| pubmed:21722302 | complex(p(HGNC:ATF6), p(HGNC:HSPA5)) decreases act(p(HGNC:ATF6)) |
| pubmed:21722302 | p(HGNC:ERN1, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(HGNC:ERN1), ma(MESH:Ribonucleases)) |
| pubmed:30606258 | p(HGNC:ERN1, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(HGNC:ERN1)) |
| pubmed:25784053 | p(HGNC:ERN1, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(HGNC:ERN1), ma(GO:"ribonuclease activity")) |
| pubmed:30740335 | act(p(HGNC:ERN1, pmod(go:0006468 ! "protein phosphorylation"))) increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") |
| pubmed:21722302 | complex(p(HGNC:ERN1), p(HGNC:TRAF2)) increases p(HGNC:MAP3K5) |
| pubmed:21722302 | p(HGNC:BAK1) increases act(p(HGNC:ERN1), ma(go:0016301 ! "kinase activity")) |
| pubmed:21722302 | p(HGNC:BAK1) increases act(p(HGNC:ERN1), ma(MESH:Endoribonucleases)) |
| pubmed:21722302 | p(HGNC:BAK1) association bp(MESH:Apoptosis) |
| pubmed:21722302 | p(HGNC:BAK1) increases bp(GO:"mitochondrial outer membrane permeabilization") |
| pubmed:21722302 | p(HGNC:BAK1) increases complex(GO:"mitochondrial permeability transition pore complex") |
| pubmed:21722302 | p(HGNC:DAB2IP) increases act(p(HGNC:ERN1)) |
| pubmed:21722302 | composite(p(HGNC:ERN1), p(MESH:"HSP72 Heat-Shock Proteins")) increases p(HGNC:XBP1) |
| pubmed:21722302 | p(HGNC:XBP1) decreases bp(MESH:Apoptosis) |
| pubmed:21722302 | p(HGNC:XBP1) increases a(MESH:"Molecular Chaperones") |
| pubmed:21722302 | p(HGNC:XBP1) decreases bp(GO:autophagy) |
| pubmed:30740335 | p(HGNC:XBP1) decreases bp(GO:autophagy) |
| pubmed:21722302 | p(HGNC:XBP1) increases p(HGNC:SOD1, pmod(MESH:"Mutant Proteins")) |
| pubmed:21722302 | p(HGNC:XBP1) regulates g(FPLX:"Gamma_secretase") |
| pubmed:21722302 | p(HGNC:XBP1) regulates p(HGNC:APP) |
| pubmed:21722302 | p(HGNC:XBP1) association path(MESH:"Alzheimer Disease") |
| pubmed:21722302 | p(HGNC:XBP1) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21722302 | p(HGNC:XBP1) association a(CHEBI:amyloid-beta) |
| pubmed:21722302 | p(HGNC:XBP1) association p(HGNC:VAPB) |
| pubmed:30740335 | p(HGNC:XBP1) increases bp(GO:"positive regulation of protein folding") |
| pubmed:30740335 | p(HGNC:XBP1) increases deg(p(MESH:"Mutant Proteins")) |
| pubmed:30740335 | p(HGNC:XBP1) increases path(MESH:"Cell Survival") |
| pubmed:30740335 | p(HGNC:XBP1) decreases p(HGNC:FOXO1) |
| pubmed:30740335 | p(HGNC:XBP1) decreases p(HGNC:FOXO1) |
| pubmed:30740335 | p(HGNC:XBP1) decreases path(MESH:Autophagy) |
| pubmed:30740335 | p(HGNC:XBP1) increases deg(p(HGNC:SOD1, pmod(HBP:misfolded))) |
| pubmed:30740335 | p(HGNC:XBP1) association bp(GO:"learning or memory") |
| pubmed:30740335 | act(p(HGNC:XBP1)) association p(HGNC:BDNF) |
| pubmed:30740335 | p(HGNC:XBP1) increases p(HGNC:HTT, pmod(HBP:misfolded)) |
| pubmed:30740335 | p(HGNC:XBP1) increases a(MESH:"Protein Aggregates") |
| pubmed:30740335 | p(HGNC:XBP1) increases bp(GO:"neuron death") |
| pubmed:25784053 | act(p(HGNC:XBP1), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases bp(GO:"response to misfolded protein") |
| pubmed:21722302 | p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 51)) decreases bp(GO:translation) |
| pubmed:21722302 | p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 51)) increases bp(GO:"cap-independent translational initiation") |
| pubmed:21722302 | p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 51)) increases p(HGNC:ATF4) |
| pubmed:21722302 | bp(GO:"cap-independent translational initiation") increases p(HGNC:ATF4) |
| pubmed:21722302 | p(HGNC:ATF4) increases a(MESH:"Molecular Chaperones") |
| pubmed:21722302 | p(HGNC:ATF4) increases p(HGNC:MAP1LC3B) |
| pubmed:21722302 | p(HGNC:ATF4) increases p(HGNC:ATG5) |
| pubmed:21722302 | p(HGNC:ATF4) increases bp(GO:autophagy) |
| pubmed:21722302 | p(HGNC:ATF4) increases p(HGNC:PRKN) |
| pubmed:30740335 | p(HGNC:ATF4) increases act(p(HGNC:DDIT3)) |
| pubmed:25784053 | p(HGNC:ATF4) increases p(HGNC:DDIT3) |
| pubmed:27299292 | p(HGNC:ATF4) association p(HGNC:TFEB) |
| pubmed:27299292 | p(HGNC:ATF4) association p(HGNC:TFE3) |
| pubmed:21722302 | a(MESH:"Molecular Chaperones") association bp(GO:"ERAD pathway") |
| pubmed:27491084 | a(MESH:"Molecular Chaperones") decreases path(CONSO:proteotoxicity) |
| pubmed:23746257 | a(MESH:"Molecular Chaperones") decreases a(MESH:"Protein Aggregates") |
| pubmed:25784053 | a(MESH:"Molecular Chaperones") increases bp(CONSO:Proteostasis) |
| pubmed:25784053 | a(MESH:"Molecular Chaperones") decreases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:21882945 | a(MESH:"Molecular Chaperones") association bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") |
| pubmed:29311797 | a(MESH:"Molecular Chaperones") association bp(GO:"protein folding") |
| pubmed:29311797 | a(MESH:"Molecular Chaperones") association bp(MESH:Proteolysis) |
| pubmed:29311797 | a(MESH:"Molecular Chaperones") association deg(p(MESH:Proteins, pmod(CONSO:misfolded))) |
| pubmed:27181519 | a(MESH:"Molecular Chaperones") regulates bp(GO:"stress granule disassembly") |
| pubmed:21722302 | bp(GO:"ERAD pathway") association a(MESH:"Molecular Chaperones") |
| pubmed:21722302 | bp(GO:"ERAD pathway") increases deg(p(MESH:Proteins, pmod(CONSO:misfolded))) |
| pubmed:21722302 | bp(GO:"ERAD pathway") increases deg(p(MESH:Proteins, pmod(CONSO:misfolded))) |
| pubmed:21722302 | bp(GO:"ERAD pathway") association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:21722302 | bp(GO:"ERAD pathway") decreases bp(MESH:"Endoplasmic Reticulum Stress") |
| pubmed:21722302 | bp(GO:"ERAD pathway") decreases p(HGNC:DERL1) |
| pubmed:21722302 | bp(GO:"ERAD pathway") negativeCorrelation complex(p(HGNC:DERL1), p(HGNC:SOD1, var("?"))) |
| pubmed:30740335 | bp(GO:"ERAD pathway") association p(HGNC:ATF6) |
| pubmed:14556719 | bp(GO:"ERAD pathway") regulates deg(p(HGNC:CFTR)) |
| pubmed:14556719 | bp(GO:"ERAD pathway") increases deg(p(HGNC:PRNP, pmod(CONSO:misfolding))) |
| pubmed:24457024 | bp(GO:"ERAD pathway") association complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(CONSO:misfolding))) |
| pubmed:21722302 | p(HGNC:CREB3L1) increases bp(MESH:"Bone Development") |
| pubmed:21722302 | p(HGNC:CREB3L2) regulates p(HGNC:SEC23A) |
| pubmed:21722302 | p(HGNC:SEC23A) increases tloc(a(MESH:Proteins), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:"Golgi apparatus")) |
| pubmed:22908190 | tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(GO:"lysosomal lumen")) increases deg(a(MESH:Proteins)) |
| pubmed:18930136 | tloc(a(MESH:Proteins), fromLoc(GO:intracellular), toLoc(GO:lysosome)) increases deg(a(MESH:Proteins)) |
| pubmed:22908190 | a(MESH:Proteins) positiveCorrelation act(p(HGNC:RAB5A)) |
| pubmed:22908190 | a(MESH:Proteins) positiveCorrelation bp(GO:endocytosis) |
| pubmed:24457024 | tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(CONSO:"20 S Proteasome")) increases act(p(HGNC:PSMD14)) |
| pubmed:27181519 | a(MESH:Proteins, loc(GO:phagophore)) increases a(GO:autophagosome) |
| pubmed:21722302 | p(HGNC:ATF3) increases a(MESH:"Molecular Chaperones") |
| pubmed:21722302 | bp(GO:"apoptotic signaling pathway") decreases complex(GO:"mitochondrial permeability transition pore complex") |
| pubmed:21722302 | composite(p(HGNC:APAF1), p(HGNC:CASP9), p(HGNC:CYC1)) increases a(MESH:Apoptosomes) |
| pubmed:21722302 | p(HGNC:CASP9) increases p(HGNC:CASP3) |
| pubmed:21722302 | p(HGNC:CASP9) increases p(HGNC:CASP7) |
| pubmed:21722302 | p(HGNC:CASP9) increases p(HGNC:CASP6) |
| pubmed:21722302 | composite(p(HGNC:CASP3), p(HGNC:CASP6), p(HGNC:CASP7)) increases bp(MESH:Apoptosis) |
| pubmed:21722302 | p(HGNC:CASP2) increases bp(MESH:Apoptosis) |
| pubmed:21722302 | complex(GO:"PUMA-BCL-2 complex") increases bp(MESH:Apoptosis) |
| pubmed:21722302 | p(HGNC:DDIT3) increases bp(MESH:"DNA Damage") |
| pubmed:21722302 | p(HGNC:DDIT3) association complex(GO:"CHOP-C/EBP complex") |
| pubmed:21722302 | p(HGNC:DDIT3) increases bp(MESH:"Cell Death") |
| pubmed:21722302 | p(HGNC:DDIT3) decreases p(HGNC:BCL2) |
| pubmed:30740335 | p(HGNC:DDIT3) decreases act(p(HGNC:BCL2)) |
| pubmed:21722302 | p(HGNC:DDIT3) increases a(MESH:"Reactive Oxygen Species") |
| pubmed:21722302 | p(HGNC:DDIT3) increases p(MGI:Casp4) |
| pubmed:21722302 | p(HGNC:DDIT3) increases complex(GO:"BIM-BCL-2 complex") |
| pubmed:21722302 | p(HGNC:DDIT3) decreases r(HGNC:BCL2) |
| pubmed:21722302 | p(HGNC:DDIT3) increases p(HGNC:MAP1LC3B) |
| pubmed:21722302 | p(HGNC:DDIT3) increases p(HGNC:ATG5) |
| pubmed:21722302 | p(HGNC:DDIT3) increases bp(GO:autophagy) |
| pubmed:21722302 | p(HGNC:DDIT3) decreases g(HGNC:PRKN) |
| pubmed:21722302 | p(HGNC:DDIT3) biomarkerFor bp(MESH:"Endoplasmic Reticulum Stress") |
| pubmed:30740335 | p(HGNC:DDIT3) increases path(MESH:Apoptosis) |
| pubmed:25784053 | p(HGNC:DDIT3) increases bp(GO:"apoptotic process") |
| pubmed:23702978 | p(HGNC:DDIT3) regulates a(CHEBI:"calcium(2+)") |
| pubmed:23702978 | p(HGNC:DDIT3) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:30126037 | bp(MESH:"DNA Damage") association bp(GO:"cellular senescence") |
| pubmed:21722302 | complex(GO:"CHOP-C/EBP complex") association p(HGNC:DDIT3) |
| pubmed:21722302 | complex(GO:"CHOP-C/EBP complex") increases bp(MESH:"Cell Death") |
| pubmed:21722302 | p(MGI:Casp4) increases p(HGNC:CASP1) |
| pubmed:21722302 | p(MGI:Casp4) increases p(HGNC:CASP3) |
| pubmed:21722302 | p(MESH:Oxidoreductases) increases tloc(p(MESH:Proteins, pmod(CONSO:misfolded)), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:cytoplasm)) |
| pubmed:21722302 | p(HGNCGENEFAMILY:Proteasome) decreases deg(p(MESH:Proteins, pmod(CONSO:misfolded))) |
| pubmed:21722302 | p(HGNCGENEFAMILY:Proteasome) increases deg(p(MESH:Proteins, pmod(CONSO:misfolded))) |
| pubmed:24027553 | act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination"))) |
| pubmed:24027553 | p(HGNCGENEFAMILY:Proteasome) increases deg(p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination"))) |
| pubmed:24027553 | act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT)) |
| pubmed:24027553 | p(HGNCGENEFAMILY:Proteasome) increases deg(p(HGNC:MAPT)) |
| pubmed:24027553 | act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT)) |
| pubmed:24027553 | act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(RGD:Mapt)) |
| pubmed:24027553 | act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404))) |
| pubmed:24027553 | act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:24027553 | act(p(HGNCGENEFAMILY:Proteasome)) causesNoChange deg(a(CONSO:"Tau aggregates")) |
| pubmed:24027553 | act(p(HGNCGENEFAMILY:Proteasome)) causesNoChange deg(a(CONSO:"Tau oligomers")) |
| pubmed:21722302 | complex(GO:"Atg1/ULK1 kinase complex") increases bp(GO:autophagy) |
| pubmed:21722302 | complex(GO:"Atg1/ULK1 kinase complex") increases a(GO:phagophore) |
| pubmed:30606258 | p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:RPS6KB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 398)) |
| pubmed:30606258 | p(HGNCGENEFAMILY:"MTOR complex 1") negativeCorrelation act(p(HGNC:INS)) |
| pubmed:30606258 | p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:IRS1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30606258 | p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:IRS1, pmod(go:0006468 ! "protein phosphorylation", Ser, 636)) |
| pubmed:30606258 | p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:IRS1, pmod(go:0006468 ! "protein phosphorylation", Ser, 639)) |
| pubmed:30606258 | p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:IRS1, pmod(go:0006468 ! "protein phosphorylation", Ser, 1101)) |
| pubmed:27209302 | act(p(HGNCGENEFAMILY:"MTOR complex 1")) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:30108137 | p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:TFEB, loc(GO:cytoplasm)) |
| pubmed:27299292 | act(p(HGNCGENEFAMILY:"MTOR complex 1"), ma(go:0016301 ! "kinase activity")) increases p(HGNC:TFEB, loc(GO:cytosol)) |
| pubmed:27299292 | p(HGNCGENEFAMILY:"MTOR complex 1") decreases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) |
| pubmed:27299292 | p(HGNCGENEFAMILY:"MTOR complex 1") decreases act(p(HGNC:TFEB)) |
| pubmed:26702100 | p(HGNCGENEFAMILY:"MTOR complex 1") regulates p(HGNC:TFEB) |
| pubmed:26702100 | p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:TFEB, loc(GO:nucleus)) |
| pubmed:26968346 | act(p(HGNCGENEFAMILY:"MTOR complex 1"), ma(go:0016301 ! "kinase activity")) increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 142)) |
| pubmed:27299292 | p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 142)) |
| pubmed:26968346 | act(p(HGNCGENEFAMILY:"MTOR complex 1"), ma(go:0016301 ! "kinase activity")) increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 211)) |
| pubmed:27299292 | p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 211)) |
| pubmed:26702100 | p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 211)) |
| pubmed:26968346 | tloc(p(HGNCGENEFAMILY:"MTOR complex 1"), fromLoc(GO:cytoplasm), toLoc(GO:"lysosomal membrane")) increases act(p(HGNCGENEFAMILY:"MTOR complex 1")) |
| pubmed:27299292 | p(HGNCGENEFAMILY:"MTOR complex 1", loc(GO:"plasma membrane")) causesNoChange act(p(HGNCGENEFAMILY:"MTOR complex 1")) |
| pubmed:30108137 | p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27299292 | act(p(HGNCGENEFAMILY:"MTOR complex 1"), ma(go:0016301 ! "kinase activity")) increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26702100 | p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27299292 | act(p(HGNCGENEFAMILY:"MTOR complex 1"), ma(go:0016301 ! "kinase activity")) association bp(GO:"biosynthetic process") |
| pubmed:27299292 | act(p(HGNCGENEFAMILY:"MTOR complex 1"), ma(go:0016301 ! "kinase activity")) association bp(GO:"catabolic process") |
| pubmed:27299292 | p(HGNCGENEFAMILY:"MTOR complex 1") positiveCorrelation p(HGNC:TSC2) |
| pubmed:27299292 | act(p(HGNCGENEFAMILY:"MTOR complex 1")) regulates act(a(MESH:Lysosomes)) |
| pubmed:27299292 | act(p(HGNCGENEFAMILY:"MTOR complex 1")) association complex(GO:"Ragulator complex") |
| pubmed:27299292 | act(p(HGNCGENEFAMILY:"MTOR complex 1")) increases p(HGNC:MITF, loc(GO:cytoplasm)) |
| pubmed:27299292 | act(p(HGNCGENEFAMILY:"MTOR complex 1")) increases p(HGNC:TFE3, loc(GO:cytoplasm)) |
| pubmed:27299292 | act(p(HGNCGENEFAMILY:"MTOR complex 1")) positiveCorrelation p(HGNC:FLCN) |
| pubmed:27299292 | tloc(p(HGNCGENEFAMILY:"MTOR complex 1"), fromLoc(GO:cytoplasm), toLoc(GO:"lysosomal membrane")) association p(HGNC:FLCN) |
| pubmed:27299292 | act(p(HGNCGENEFAMILY:"MTOR complex 1")) association p(HGNC:FLCN) |
| pubmed:27299292 | act(p(HGNCGENEFAMILY:"MTOR complex 1")) decreases p(HGNC:AR, pmod(CONSO:"CAG repeats")) |
| pubmed:27299292 | act(p(HGNCGENEFAMILY:"MTOR complex 1")) negativeCorrelation path(DOID:"spinal muscular atrophy") |
| pubmed:27299292 | p(HGNCGENEFAMILY:"MTOR complex 1") association p(HGNC:SESN2) |
| pubmed:27299292 | p(HGNCGENEFAMILY:"MTOR complex 1") negativeCorrelation complex(p(HGNC:IPO8), p(HGNC:TFE3)) |
| pubmed:27299292 | p(HGNCGENEFAMILY:"MTOR complex 1") negativeCorrelation complex(p(HGNC:IPO8), p(HGNC:TFEB)) |
| pubmed:27299292 | p(HGNCGENEFAMILY:"MTOR complex 1") negativeCorrelation complex(p(HGNC:IPO8), p(HGNC:MITF)) |
| pubmed:26702100 | act(p(HGNCGENEFAMILY:"MTOR complex 1")) negativeCorrelation p(HGNC:RPS6KB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 389)) |
| pubmed:26702100 | act(p(HGNCGENEFAMILY:"MTOR complex 1")) association p(HGNC:RPS6KB1) |
| pubmed:26702100 | p(HGNCGENEFAMILY:"MTOR complex 1") association act(p(HGNC:TARDBP)) |
| pubmed:21722302 | p(HGNCGENEFAMILY:"TSC complex") regulates p(HGNC:MTOR) |
| pubmed:21722302 | path(MESH:Starvation) increases act(p(HGNC:PRKAA1)) |
| pubmed:26968346 | path(MESH:Starvation) decreases p(HGNCGENEFAMILY:"MTOR complex 1") |
| pubmed:26968346 | path(MESH:Starvation) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:29758300 | path(MESH:Starvation) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) |
| pubmed:26968346 | path(MESH:Starvation) increases composite(a(CHEBI:"calcium(2+)"), p(HGNC:MCOLN1)) |
| pubmed:30562574 | path(MESH:Starvation) increases bp(GO:"chaperone-mediated autophagy") |
| pubmed:29758300 | path(MESH:Starvation) increases rxn(reactants(a(CHEBI:lipid)), products(a(CHEBI:"fatty acid"), a(CHEBI:ATP))) |
| pubmed:29758300 | path(MESH:Starvation) increases complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) |
| pubmed:18930136 | path(MESH:Starvation) increases tloc(p(HGNC:WDFY3), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) |
| pubmed:29238289 | path(MESH:Starvation) increases tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:26702100 | path(MESH:Starvation) decreases p(HGNC:MTOR) |
| pubmed:26702100 | path(MESH:Starvation) decreases p(HGNC:RPS6KB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 389)) |
| pubmed:26702100 | path(MESH:Starvation) increases a(GO:autophagosome) |
| pubmed:26702100 | path(MESH:Starvation) decreases a(GO:autolysosome) |
| pubmed:21722302 | bp(MESH:"Heat-Shock Response") increases act(p(HGNC:PRKAA1)) |
| pubmed:14556719 | bp(MESH:"Heat-Shock Response") increases bp(GO:"response to unfolded protein") |
| pubmed:23746257 | bp(MESH:"Heat-Shock Response") increases a(MESH:"Heat-Shock Proteins") |
| pubmed:23746257 | bp(MESH:"Heat-Shock Response") association p(FPLX:HSP90) |
| pubmed:23746257 | bp(MESH:"Heat-Shock Response") regulates bp(CONSO:Proteostasis) |
| pubmed:29807032 | bp(MESH:"Heat-Shock Response") association act(p(NCBIGENE:140621)) |
| pubmed:29807032 | bp(MESH:"Heat-Shock Response") increases act(p(NCBIGENE:140621)) |
| pubmed:29807032 | bp(MESH:"Heat-Shock Response") increases p(NCBIGENE:492507) |
| pubmed:29807032 | bp(MESH:"Heat-Shock Response") increases r(MESH:"corticotropin releasing factor-binding protein") |
| pubmed:29807032 | bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") |
| pubmed:29807032 | bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") |
| pubmed:29807032 | bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") |
| pubmed:21722302 | a(CHEBI:tunicamycin) increases bp(GO:autophagy) |
| pubmed:30740335 | a(CHEBI:tunicamycin) increases path(MESH:"Endoplasmic Reticulum Stress") |
| pubmed:21722302 | a(MESH:"Proteasome Inhibitors") increases bp(GO:autophagy) |
| pubmed:21722302 | p(HGNC:SOD1, pmod(MESH:"Mutant Proteins")) increases bp(CONSO:"protein aggregation") |
| pubmed:21722302 | p(HGNC:HTT, pmod(MESH:polyglutamine)) increases p(HGNC:EIF2AK3) |
| pubmed:21722302 | composite(p(HGNC:ATG12), p(HGNC:HTT, pmod(MESH:polyglutamine))) increases bp(GO:autophagy) |
| pubmed:27299292 | p(HGNC:ATG5) association composite(p(HGNC:MITF), p(HGNC:TFE3), p(HGNC:TFEB)) |
| pubmed:18930136 | p(HGNC:ATG5) decreases path(CONSO:Neurodegeneration) |
| pubmed:26702100 | p(HGNC:ATG5) association bp(GO:autophagy) |
| pubmed:21722302 | p(HGNC:NUPR1) increases bp(GO:autophagy) |
| pubmed:21722302 | p(HGNC:TRIB3) increases bp(GO:autophagy) |
| pubmed:21722302 | path(MESH:"Amyloidosis, Cerebral, with Spongiform Encephalopathy") association bp(CONSO:"protein aggregation") |
| pubmed:21722302 | path(MESH:"Brain Ischemia") association bp(CONSO:"protein aggregation") |
| pubmed:21722302 | path(HP:"Senile plaques") association path(MESH:"Alzheimer Disease") |
| pubmed:21722302 | path(HP:"Senile plaques") increases a(CONSO:"amyloid-beta aggregates") |
| pubmed:21722302 | path(HP:"Senile plaques") increases a(MESH:"Neurofibrillary Tangles") |
| pubmed:21722302 | path(HP:"Senile plaques") increases a(MESH:"Neurofibrillary Tangles") |
| pubmed:21722302 | path(HP:"Senile plaques") association path(MESH:"Neurodegenerative Diseases") |
| pubmed:21722302 | path(MESH:Neurites) association path(MESH:"Alzheimer Disease") |
| pubmed:21722302 | p(PFAM:Presenilin) isA complex(GO:"ER membrane protein complex") |
| pubmed:21722302 | p(PFAM:Presenilin) association p(HGNC:ERN1) |
| pubmed:21722302 | p(PFAM:Presenilin) association p(HGNC:EIF2AK3) |
| pubmed:21722302 | p(PFAM:Presenilin) decreases p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21722302 | p(PFAM:Presenilin) decreases p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21722302 | p(PFAM:Presenilin, var("?")) association path(MESH:"Alzheimer Disease") |
| pubmed:21722302 | p(PFAM:Presenilin, var("?")) decreases path(MESH:"Age of Onset") |
| pubmed:21722302 | p(HGNC:UBQLN1) negativeCorrelation complex(FPLX:"Gamma_secretase") |
| pubmed:21722302 | p(HGNC:UBQLN1) regulates p(HGNC:APP) |
| pubmed:21722302 | p(HGNC:UBQLN1) regulates a(CHEBI:amyloid-beta) |
| pubmed:22908190 | p(HGNC:UBQLN1) association path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | p(HGNC:UBQLN1) increases complex(a(GO:"proteasome complex"), p(HGNC:UBQLN1)) |
| pubmed:22908190 | p(HGNC:UBQLN1) increases complex(p(HGNC:UBQLN1), p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"))) |
| pubmed:22908190 | p(HGNC:UBQLN1) regulates deg(p(HGNC:PSEN1)) |
| pubmed:21722302 | path(HP:"Postural instability") prognosticBiomarkerFor path(MESH:"Parkinson Disease") |
| pubmed:21722302 | path(HP:"Resting tremor") prognosticBiomarkerFor path(MESH:"Parkinson Disease") |
| pubmed:21722302 | path(DOID:"olfactory nerve disease") prognosticBiomarkerFor path(MESH:"Parkinson Disease") |
| pubmed:21722302 | path(CONSO:"Gastrointestinal dysfunctions") prognosticBiomarkerFor path(MESH:"Parkinson Disease") |
| pubmed:21722302 | a(GO:"Lewy neurite") biomarkerFor path(MESH:"Parkinson Disease") |
| pubmed:21722302 | path(DOID:"autosomal dominant Parkinson's disease 1") association g(HGNC:SNCA) |
| pubmed:21722302 | path(DOID:"autosomal dominant Parkinson's disease 1") association g(HGNC:UCHL1) |
| pubmed:21722302 | path(DOID:"autosomal dominant Parkinson's disease 1") association g(HGNC:LRRK2) |
| pubmed:21722302 | path(DOID:"autosomal dominant Parkinson's disease 1") association p(HGNC:UCHL1, var("?")) |
| pubmed:21722302 | g(HGNC:SNCA) association path(DOID:"autosomal dominant Parkinson's disease 1") |
| pubmed:21722302 | g(HGNC:UCHL1) association path(DOID:"autosomal dominant Parkinson's disease 1") |
| pubmed:21722302 | g(HGNC:LRRK2) association path(DOID:"autosomal dominant Parkinson's disease 1") |
| pubmed:21722302 | path(DOID:"autosomal recessive Parkinson's disease 14") association g(HGNC:PRKN) |
| pubmed:21722302 | path(DOID:"autosomal recessive Parkinson's disease 14") association g(HGNC:PINK1) |
| pubmed:21722302 | path(DOID:"autosomal recessive Parkinson's disease 14") association g(HGNC:PARK7) |
| pubmed:21722302 | path(DOID:"autosomal recessive Parkinson's disease 14") association g(HGNC:ATP13A2) |
| pubmed:21722302 | path(DOID:"autosomal recessive Parkinson's disease 14") association g(HGNC:PRKN, var("?")) |
| pubmed:21722302 | g(HGNC:PRKN) association path(DOID:"autosomal recessive Parkinson's disease 14") |
| pubmed:21722302 | g(HGNC:PINK1) association path(DOID:"autosomal recessive Parkinson's disease 14") |
| pubmed:21722302 | g(HGNC:PARK7) association path(DOID:"autosomal recessive Parkinson's disease 14") |
| pubmed:21722302 | g(HGNC:ATP13A2) association path(DOID:"autosomal recessive Parkinson's disease 14") |
| pubmed:21722302 | p(HGNC:SNCA, pmod(go:0017014 ! "protein nitrosylation")) increases p(HGNC:SNCA, pmod(CONSO:misfolded)) |
| pubmed:21722302 | p(HGNC:SNCA, var("p.Ala53Thr")) increases bp(MESH:"Unfolded Protein Response") |
| pubmed:14556719 | p(HGNC:SNCA, var("p.Ala53Thr")) association path(MESH:"Parkinson Disease") |
| pubmed:28803412 | p(HGNC:SNCA, var("p.Ala53Thr")) increases path(MESH:"Parkinson Disease") |
| pubmed:14556719 | p(HGNC:SNCA, var("p.Ala53Thr")) increases a(CONSO:"alpha-synuclein fibrils") |
| pubmed:21722302 | composite(p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:SNCA, var("p.Ala53Thr"))) increases bp(MESH:"Cell Death") |
| pubmed:27299292 | bp(GO:"protein catabolic process") increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) |
| pubmed:27299292 | bp(GO:"protein catabolic process") increases deg(p(HGNC:MAPT, pmod(CONSO:misfolded))) |
| pubmed:14556719 | bp(GO:"protein catabolic process") increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:23746257 | bp(GO:"protein catabolic process") association act(p(FPLX:HSPA)) |
| pubmed:21722302 | p(HGNC:UCHL1, var("?")) association path(DOID:"autosomal dominant Parkinson's disease 1") |
| pubmed:21722302 | p(HGNC:UCHL1, var("?")) decreases bp(GO:"chaperone-mediated autophagy") |
| pubmed:14556719 | p(HGNC:UCHL1, var("?")) association path(MESH:"Parkinson Disease") |
| pubmed:14556719 | p(HGNC:UCHL1, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:23528736 | p(HGNC:UCHL1, var("?")) association path(MESH:"Neurodegenerative Diseases") |
| pubmed:23528736 | p(HGNC:UCHL1, var("?")) association path(MESH:"Alzheimer Disease") |
| pubmed:21722302 | bp(GO:"chaperone-mediated autophagy") association p(HGNC:UCHL1) |
| pubmed:21722302 | bp(GO:"chaperone-mediated autophagy") increases deg(a(CONSO:"alpha-synuclein aggregates")) |
| pubmed:26968346 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:HTT)) |
| pubmed:30116051 | bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(HGNC:HTT)) |
| pubmed:26968346 | bp(GO:"chaperone-mediated autophagy") negativeCorrelation p(HGNC:SNCA, var("?")) |
| pubmed:29758300 | bp(GO:"chaperone-mediated autophagy") association p(HGNC:SNCA, var("?")) |
| pubmed:26968346 | bp(GO:"chaperone-mediated autophagy") decreases p(CONSO:"alpha-synuclein aggregates") |
| pubmed:27299292 | bp(GO:"chaperone-mediated autophagy") positiveCorrelation deg(p(HGNC:TFEB)) |
| pubmed:27299292 | bp(GO:"chaperone-mediated autophagy") decreases bp(GO:macroautophagy) |
| pubmed:30562574 | bp(GO:"chaperone-mediated autophagy") negativeCorrelation bp(GO:macroautophagy) |
| pubmed:30562574 | bp(GO:"chaperone-mediated autophagy") increases deg(a(MESH:Proteins, loc(GO:lysosome))) |
| pubmed:22908190 | bp(GO:"chaperone-mediated autophagy") increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(GO:"lysosomal lumen")) |
| pubmed:18930136 | bp(GO:"chaperone-mediated autophagy") increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:"lysosomal lumen")) |
| pubmed:30562574 | bp(GO:"chaperone-mediated autophagy") association path(MESH:"Neurodegenerative Diseases") |
| pubmed:29311797 | bp(GO:"chaperone-mediated autophagy") negativeCorrelation path(MESH:"Neurodegenerative Diseases") |
| pubmed:30562574 | bp(GO:"chaperone-mediated autophagy") association path(DOID:"Parkinson's disease") |
| pubmed:30562574 | bp(GO:"chaperone-mediated autophagy") association bp(GO:aging) |
| pubmed:30562574 | bp(GO:"chaperone-mediated autophagy") isA bp(GO:"cellular protein catabolic process") |
| pubmed:29758300 | bp(GO:"chaperone-mediated autophagy") decreases a(CONSO:"protein aggregates") |
| pubmed:29758300 | bp(GO:"chaperone-mediated autophagy") causesNoChange deg(a(CONSO:"protein aggregates")) |
| pubmed:29758300 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) |
| pubmed:22908190 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) |
| pubmed:30116051 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) |
| pubmed:30116051 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) |
| pubmed:29758300 | bp(GO:"chaperone-mediated autophagy") association p(HGNC:SNCA) |
| pubmed:29758300 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) |
| pubmed:18930136 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) |
| pubmed:18930136 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) |
| pubmed:18930136 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) |
| pubmed:30116051 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) |
| pubmed:30116051 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) |
| pubmed:18930136 | bp(GO:"chaperone-mediated autophagy") association p(HGNC:HSPA8) |
| pubmed:24563850 | bp(GO:"chaperone-mediated autophagy") decreases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30116051 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:TARDBP)) |
| pubmed:30116051 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:APP)) |
| pubmed:30116051 | bp(GO:"chaperone-mediated autophagy") causesNoChange deg(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pubmed:30116051 | bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(HGNC:HTT, var("?"))) |
| pubmed:30116051 | bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(HGNC:HTT, frag("?"))) |
| pubmed:30116051 | bp(GO:"chaperone-mediated autophagy") increases act(p(HGNC:MEF2D)) |
| pubmed:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt)) |
| pubmed:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt)) |
| pubmed:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt)) |
| pubmed:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(p(CONSO:CONSO00053)) |
| pubmed:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(p(CONSO:CONSO00053)) |
| pubmed:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) |
| pubmed:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) |
| pubmed:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) |
| pubmed:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Pro301Leu"))) |
| pubmed:29024336 | bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(MGI:Mapt, var("p.Pro301Leu"))) |
| pubmed:29024336 | bp(GO:"chaperone-mediated autophagy") decreases path(MESH:"Proteostasis Deficiencies") |
| pubmed:25374103 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT, pmod(CONSO:misfolded))) |
| pubmed:29311797 | bp(GO:"chaperone-mediated autophagy") association p(FPLX:HSP90) |
| pubmed:29311797 | bp(GO:"chaperone-mediated autophagy") association p(HGNC:STIP1) |
| pubmed:21722302 | g(HGNC:PRKN, var("?")) association path(DOID:"autosomal recessive Parkinson's disease 14") |
| pubmed:21722302 | g(HGNC:PRKN, var("?")) decreases bp(MESH:"Protein Stability") |
| pubmed:21722302 | bp(GO:"negative regulation of ubiquitin protein ligase activity") increases p(MESH:Proteins, pmod(CONSO:misfolded)) |
| pubmed:21722302 | p(HGNCGENEFAMILY:"Voltage dependent anion channels", pmod(go:0016567 ! "protein ubiquitination")) increases bp(MESH:"Mitochondrial Degradation") |
| pubmed:21722302 | bp(GO:"parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization") association path(MESH:"Parkinson Disease") |
| pubmed:21722302 | bp(MESH:"Protein Stability") association p(HGNC:PINK1, var("?")) |
| pubmed:21722302 | p(HGNC:PARK7, var("?")) association path(MESH:"Parkinson Disease") |
| pubmed:21722302 | p(HGNC:PARK7, var("?")) increases bp(MESH:"Oxidative Stress") |
| pubmed:21722302 | p(HGNC:PARK7, var("?")) increases bp(MESH:"Endoplasmic Reticulum Stress") |
| pubmed:24563850 | bp(GO:"detection of redox state") association a(CHEBI:radical) |
| pubmed:21722302 | a(MESH:Paraquat) isA a(CHEBI:herbicide) |
| pubmed:21722302 | a(MESH:Paraquat) association path(MESH:"Parkinson Disease") |
| pubmed:21722302 | a(MESH:Paraquat) increases p(HGNC:HSPA5) |
| pubmed:21722302 | a(MESH:Paraquat) increases p(HGNC:DDIT3) |
| pubmed:21722302 | a(MESH:Paraquat) increases act(p(HGNC:ERN1)) |
| pubmed:21722302 | a(MESH:Paraquat) increases act(p(HGNC:MAP3K5)) |
| pubmed:21722302 | a(MESH:Paraquat) increases bp(GO:"JNK cascade") |
| pubmed:21722302 | a(MESH:Paraquat) increases bp(MESH:Apoptosis) |
| pubmed:21722302 | g(HGNC:PINK1, var("?")) decreases bp(MESH:"Protein Stability") |
| pubmed:21722302 | g(HGNC:PARK7, var("?")) decreases bp(MESH:"Protein Stability") |
| pubmed:14556719 | g(HGNC:PARK7, var("?")) association path(MESH:"Parkinsonian Disorders") |
| pubmed:21722302 | g(HGNC:SNCA, var("?")) decreases bp(MESH:"Protein Stability") |
| pubmed:21722302 | a(MESH:1-Methyl-4-phenylpyridinium) increases path(MESH:"Parkinson Disease") |
| pubmed:21722302 | a(MESH:1-Methyl-4-phenylpyridinium) directlyIncreases bp(MESH:"Endoplasmic Reticulum Stress") |
| pubmed:30562574 | act(a(MESH:1-Methyl-4-phenylpyridinium)) increases bp(GO:"cell death") |
| pubmed:21722302 | a(MESH:Hydroxydopamines) directlyIncreases bp(MESH:"Endoplasmic Reticulum Stress") |
| pubmed:25036637 | bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") association p(HGNC:LTN1) |
| pubmed:21882945 | bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") association a(MESH:"Molecular Chaperones") |
| pubmed:21882945 | bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") association p(HGNC:MAPT, var("?")) |
| pubmed:27181519 | bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") association a(CHEBI:"all-trans-retinoic acid") |
| pubmed:21722302 | a(CONSO:"Motor Neurons") association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:21722302 | bp(GO:"motor neuron apoptotic process") association bp(GO:"axonal transport") |
| pubmed:27181519 | bp(GO:"motor neuron apoptotic process") positiveCorrelation path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:27181519 | bp(GO:"motor neuron apoptotic process") positiveCorrelation bp(GO:"muscle atrophy") |
| pubmed:21722302 | a(GO:"Bunina body") association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:14556719 | a(GO:"Bunina body") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) |
| pubmed:14556719 | a(GO:"Bunina body") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) |
| pubmed:21722302 | a(CHEBI:ubiquitin) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:21722302 | p(HGNCGENEFAMILY:"Protein disulfide isomerases") association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:24563850 | p(HGNCGENEFAMILY:"Protein disulfide isomerases") decreases bp(GO:"protein oxidation") |
| pubmed:24563850 | p(HGNCGENEFAMILY:"Protein disulfide isomerases") decreases bp(CONSO:misfolding) |
| pubmed:24563850 | p(HGNCGENEFAMILY:"Protein disulfide isomerases") decreases a(MESH:"Protein Aggregates") |
| pubmed:21722302 | p(HGNC:DERL1) increases p(HGNC:MAP3K5) |
| pubmed:21722302 | complex(p(HGNC:DERL1), p(HGNC:SOD1, var("?"))) negativeCorrelation bp(GO:"ERAD pathway") |
| pubmed:21722302 | p(HGNC:VAPB, var("?")) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:21722302 | p(HGNC:VAPB, var("?")) decreases bp(MESH:"Unfolded Protein Response") |
| pubmed:21722302 | p(HGNC:VAPB, var("?")) increases bp(CONSO:"protein aggregation") |
| pubmed:21722302 | p(HGNC:VAPB) association bp(MESH:"Unfolded Protein Response") |
| pubmed:21722302 | p(HGNC:VAPB) association p(HGNC:XBP1) |
| pubmed:21722302 | p(HGNC:VAPB) association p(HGNC:ERN1) |
| pubmed:21722302 | p(HGNC:VAPB) association p(HGNC:ATF6) |
| pubmed:21722302 | p(HGNC:VAPB, pmod(go:0016567 ! "protein ubiquitination"), var("p.Pro56Ser")) decreases p(HGNC:XBP1) |
| pubmed:21722302 | p(HGNC:VAPB, pmod(go:0016567 ! "protein ubiquitination"), var("p.Pro56Ser")) decreases p(HGNC:ERN1) |
| pubmed:21722302 | p(HGNC:VAPB, pmod(go:0016567 ! "protein ubiquitination"), var("p.Pro56Ser")) decreases p(HGNC:ATF6) |
| pubmed:21722302 | complex(p(HGNC:ATF6), p(HGNC:VAPB)) decreases act(p(HGNC:ATF6)) |
| pubmed:21722302 | complex(p(HGNC:ATF6), p(HGNC:VAPB, pmod(go:0016567 ! "protein ubiquitination"), var("p.Pro56Ser"))) decreases act(p(HGNC:ATF6)) |
| pubmed:21722302 | p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) biomarkerFor path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:22908190 | p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:22908190 | p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:21722302 | p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) biomarkerFor path(MESH:"Frontotemporal Lobar Degeneration") |
| pubmed:22908190 | p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) positiveCorrelation path(MESH:"Frontotemporal Lobar Degeneration") |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) association path(MESH:"Frontotemporal Lobar Degeneration") |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) association path(MESH:"Lewy Body Disease") |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) association path(MESH:"Supranuclear Palsy, Progressive") |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) association path(MESH:"Pick Disease of the Brain") |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) association path(MESH:Sclerosis) |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) association path(MESH:"Alzheimer Disease") |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) association path(MESH:"Huntington Disease") |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) association path(MESH:"Parkinson Disease") |
| pubmed:21722302 | path(DOID:"variant Creutzfeldt-Jakob disease") isA path(DOID:"prion disease") |
| pubmed:21722302 | path(DOID:"variant Creutzfeldt-Jakob disease") isA path(DOID:"neurodegenerative disease") |
| pubmed:21722302 | path(DOID:"variant Creutzfeldt-Jakob disease") increases path(MESH:"Spongiform Encephalopathy with Neuropsychiatric Features") |
| pubmed:21722302 | path(DOID:"variant Creutzfeldt-Jakob disease") increases bp(CONSO:"protein aggregation") |
| pubmed:27181519 | path(DOID:"prion disease") association p(MESH:Proteins, pmod(CONSO:misfolded)) |
| pubmed:27181519 | path(DOID:"prion disease") increases p(MESH:Proteins, pmod(CONSO:misfolded)) |
| pubmed:21722302 | p(HGNC:PRNP, frag("106_126")) increases bp(MESH:Apoptosis) |
| pubmed:21722302 | bp(GO:"neuron development") association p(HGNC:PRNP) |
| pubmed:18494933 | bp(GO:"neuron development") negativeCorrelation act(p(HGNC:GSK3B)) |
| pubmed:16973293 | bp(GO:"neuron development") positiveCorrelation p(CONSO:"MARK4 isoform 2 (688 aa)") |
| pubmed:30837838 | bp(GO:"neuron development") association p(HGNC:TARDBP) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) negativeCorrelation act(p(HGNC:GSK3B)) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases p(HGNC:GSK3B) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases path(DOID:"cognitive disorder") |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases path(MESH:"Motor Disorders") |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) negativeCorrelation p(MESH:Proteins, loc(GO:"synaptic membrane")) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) decreases composite(p(CONSO:"Tau isoform F (441 aa)", frag("187_441")), p(INTERPRO:"Alpha tubulin")) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation", Lys, 40)) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) decreases bp(GO:"cytoskeleton organization") |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) decreases bp(GO:"microtubule bundle formation") |
| pubmed:30606258 | act(p(CONSO:"Tau isoform F (441 aa)", frag("187_441")), ma(GO:"microtubule binding")) negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", frag("187_441"), pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) decreases act(p(HGNC:AKT1)) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) decreases act(p(HGNC:AKT1)) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) negativeCorrelation act(p(HGNC:INS)) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases act(p(HGNCGENEFAMILY:"MTOR complex 1")) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases act(p(HGNC:RPS6KB1)) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases p(HGNC:IRS1, pmod(go:0006468 ! "protein phosphorylation", Ser, 636)) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases p(HGNC:IRS1, pmod(go:0006468 ! "protein phosphorylation", Ser, 639)) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases act(p(HGNC:EIF2AK3)) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases bp(GO:"PERK-mediated unfolded protein response") |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases p(HGNC:ATF6, frag("?")) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases bp(GO:"ATF6-mediated unfolded protein response") |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) causesNoChange p(HGNC:ERN1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) causesNoChange bp(GO:"IRE1-mediated unfolded protein response") |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases p(HGNCGENEFAMILY:"CCAAT/enhancer binding proteins") |
| pubmed:30606258 | complex(a(MESH:Microtubules), p(CONSO:"Tau isoform F (441 aa)")) increases bp(GO:"microtubule cytoskeleton organization") |
| pubmed:30606258 | p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation", Lys, 40)) causesNoChange act(p(CONSO:"Tau isoform F (441 aa)", frag("187_441")), ma(GO:"microtubule binding")) |
| pubmed:30606258 | p(NCIT:C17421) increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation", Lys, 40)) |
| pubmed:30606258 | p(NCIT:C17421) decreases p(HGNC:ATF6, frag("?")) |
| pubmed:30606258 | p(NCIT:C17421) causesNoChange p(HGNC:ERN1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30606258 | p(NCIT:C17421) causesNoChange bp(GO:"IRE1-mediated unfolded protein response") |
| pubmed:30606258 | p(HGNC:ATAT1) increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation", Lys, 40)) |
| pubmed:30606258 | composite(p(CONSO:"Tau isoform F (441 aa)"), p(HGNC:ATAT1)) increases bp(GO:"microtubule bundle formation") |
| pubmed:30606258 | p(CONSO:"Tau isoform F (441 aa)", frag("187_441"), pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation act(p(CONSO:"Tau isoform F (441 aa)", frag("187_441")), ma(GO:"microtubule binding")) |
| pubmed:30606258 | a(CHEBI:"lithium chloride") decreases p(HGNC:GSK3A) |
| pubmed:30606258 | a(CHEBI:"lithium chloride") decreases p(CONSO:"Tau isoform F (441 aa)", frag("187_441"), pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:30606258 | a(CHEBI:"lithium chloride") decreases p(CONSO:"Tau isoform F (441 aa)", frag("187_441"), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:30606258 | a(CHEBI:"lithium chloride") causesNoChange complex(a(MESH:Microtubules), p(CONSO:"Tau isoform F (441 aa)", frag("187_441"))) |
| pubmed:30606258 | a(CHEBI:"lithium chloride") causesNoChange bp(GO:"microtubule polymerization or depolymerization") |
| pubmed:30606258 | bp(GO:"regulation of insulin receptor signaling pathway") association act(p(HGNC:AKT1)) |
| pubmed:30606258 | bp(GO:"regulation of insulin receptor signaling pathway") association p(HGNC:GSK3B) |
| pubmed:30606258 | p(HGNC:RPS6KB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 398)) increases act(p(HGNC:RPS6KB1)) |
| pubmed:30606258 | act(p(HGNC:RPS6KB1)) negativeCorrelation act(p(HGNC:INS)) |
| pubmed:30606258 | act(p(HGNC:RPS6KB1)) increases p(HGNC:IRS1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30606258 | act(p(HGNC:RPS6KB1)) increases p(HGNC:IRS1, pmod(go:0006468 ! "protein phosphorylation", Ser, 636)) |
| pubmed:30606258 | act(p(HGNC:RPS6KB1)) increases p(HGNC:IRS1, pmod(go:0006468 ! "protein phosphorylation", Ser, 639)) |
| pubmed:30606258 | act(p(HGNC:RPS6KB1)) increases p(HGNC:IRS1, pmod(go:0006468 ! "protein phosphorylation", Ser, 1101)) |
| pubmed:30606258 | act(p(HGNC:RPS6KB1)) increases p(HGNC:IRS1, pmod(go:0006468 ! "protein phosphorylation", Ser, 1101)) |
| pubmed:17493042 | p(HGNC:RPS6KB1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser)) |
| pubmed:26702100 | p(HGNC:RPS6KB1) association act(p(HGNCGENEFAMILY:"MTOR complex 1")) |
| pubmed:30606258 | p(HGNC:IRS1, pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(HGNC:INS)) |
| pubmed:30606258 | composite(p(CONSO:"Tau isoform F (441 aa)", frag("187_441")), p(HGNCGENEFAMILY:"MTOR complex 1")) increases p(HGNC:RPS6KB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 398)) |
| pubmed:30606258 | composite(p(CONSO:"Tau isoform F (441 aa)"), p(HGNCGENEFAMILY:"MTOR complex 1")) causesNoChange p(HGNC:RPS6KB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 398)) |
| pubmed:30740335 | p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) decreases path(MESH:"Protein Biosynthesis") |
| pubmed:30740335 | p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) decreases path(MESH:"Protein Biosynthesis") |
| pubmed:30740335 | p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) decreases bp(GO:"protein secretion") |
| pubmed:30740335 | p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) increases path(MESH:"Memory Disorders") |
| pubmed:30740335 | p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) increases path(MESH:"Nerve Degeneration") |
| pubmed:30740335 | p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) association path(MESH:"Long-Term Potentiation") |
| pubmed:25784053 | p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(HGNC:EIF2S1), ma(GO:"translation regulator activity")) |
| pubmed:23702978 | p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) decreases bp(GO:translation) |
| pubmed:30740335 | p(HGNC:EIF2S1) isA a(MESH:"Neuroprotective Agents") |
| pubmed:25784053 | act(p(HGNC:EIF2S1), ma(GO:"translation regulator activity")) increases p(HGNC:ATF4) |
| pubmed:30606258 | p(HGNC:ATF6, frag("?")) increases bp(GO:"ATF6-mediated unfolded protein response") |
| pubmed:30606258 | composite(a(CHEBI:thapsigargin), p(CONSO:"Tau isoform F (441 aa)", frag("187_441"))) increases act(p(HGNC:EIF2AK3)) |
| pubmed:30606258 | composite(a(CHEBI:thapsigargin), p(CONSO:"Tau isoform F (441 aa)", frag("187_441"))) increases act(p(HGNC:ERN1)) |
| pubmed:30606258 | composite(a(CHEBI:thapsigargin), p(CONSO:"Tau isoform F (441 aa)", frag("187_441"))) increases path(EFO:"Endoplasmic Reticulum Stress") |
| pubmed:30740335 | path(MESH:"Unfolded Protein Response") association path(MESH:"Cell Survival") |
| pubmed:30740335 | path(MESH:"Unfolded Protein Response") association bp(GO:"protein stabilization") |
| pubmed:30740335 | path(MESH:"Unfolded Protein Response") increases path(MESH:Homeostasis) |
| pubmed:30740335 | path(MESH:"Unfolded Protein Response") increases path(MESH:"Organelle Biogenesis") |
| pubmed:30740335 | path(MESH:"Unfolded Protein Response") increases bp(GO:"ERAD pathway") |
| pubmed:30740335 | path(MESH:"Unfolded Protein Response") increases bp(GO:autophagy) |
| pubmed:30740335 | path(MESH:"Unfolded Protein Response") association p(HGNC:HSPA5) |
| pubmed:30740335 | path(MESH:"Unfolded Protein Response") increases act(p(HGNC:EIF2AK3)) |
| pubmed:30740335 | bp(GO:"protein stabilization") association path(MESH:"Unfolded Protein Response") |
| pubmed:30740335 | composite(a(MESH:"Endoplasmic Reticulum"), a(MESH:Mitochondria)) regulates bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") |
| pubmed:30740335 | p(MESH:"Mutant Proteins") increases bp(GO:"ubiquitin-dependent protein catabolic process") |
| pubmed:30740335 | p(MESH:"Mutant Proteins") increases bp(GO:"lysosomal protein catabolic process") |
| pubmed:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cell cycle") |
| pubmed:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cell division") |
| pubmed:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cell differentiation") |
| pubmed:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(MESH:"Cell Proliferation") |
| pubmed:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cellular response to stress") |
| pubmed:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates a(MESH:"Receptors, Cell Surface") |
| pubmed:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates a(MESH:"Ion Channels") |
| pubmed:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(MESH:"Secretory Pathway") |
| pubmed:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"DNA repair") |
| pubmed:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"gene silencing") |
| pubmed:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"long-term memory") |
| pubmed:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"circadian rhythm") |
| pubmed:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"immune response") |
| pubmed:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"inflammatory response") |
| pubmed:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"organelle organization") |
| pubmed:30740335 | bp(GO:"endoplasmic reticulum unfolded protein response") decreases path(HBP:proteotoxicity) |
| pubmed:30740335 | p(MESH:Proteins, pmod(HBP:misfolded)) increases path(HBP:proteotoxicity) |
| pubmed:30740335 | p(MESH:Proteins, pmod(HBP:misfolded), loc(GO:"endoplasmic reticulum")) decreases complex(p(HGNC:HSPA5)) |
| pubmed:30740335 | bp(GO:"mitochondrial unfolded protein response") decreases path(HBP:proteotoxicity) |
| pubmed:30740335 | path(MESH:"Protein Modification, Translational") increases path(MESH:"Protein Unfolding") |
| pubmed:30740335 | bp(GO:"negative regulation of calcium ion transport") increases path(MESH:"Protein Unfolding") |
| pubmed:30740335 | path(MESH:"Endoplasmic Reticulum Stress") association path(MESH:"Nervous System Diseases") |
| pubmed:30740335 | path(MESH:"Endoplasmic Reticulum Stress") association path(MESH:"Diabetes Mellitus") |
| pubmed:30740335 | path(MESH:"Endoplasmic Reticulum Stress") association path(MESH:Neoplasms) |
| pubmed:30740335 | path(MESH:"Endoplasmic Reticulum Stress") association path(MESH:"Heart Diseases") |
| pubmed:30740335 | path(MESH:"Endoplasmic Reticulum Stress") association path(MESH:"Lung Diseases") |
| pubmed:30740335 | path(MESH:"Endoplasmic Reticulum Stress") association path(MESH:"Kidney Diseases") |
| pubmed:30740335 | path(MESH:"Endoplasmic Reticulum Stress") association p(HGNC:UCHL1) |
| pubmed:30740335 | path(MESH:"Nervous System Diseases") association path(MESH:"Endoplasmic Reticulum Stress") |
| pubmed:30740335 | path(MESH:"Heart Diseases") association path(MESH:"Endoplasmic Reticulum Stress") |
| pubmed:30740335 | path(MESH:"Lung Diseases") association path(MESH:"Endoplasmic Reticulum Stress") |
| pubmed:30740335 | p(HGNC:XBP1, frag("?")) regulates path(MESH:"Unfolded Protein Response") |
| pubmed:30740335 | p(HGNC:XBP1, frag("?")) regulates bp(GO:"ERAD pathway") |
| pubmed:30837838 | path(MESH:"Protein Biosynthesis") association p(HGNC:TARDBP) |
| pubmed:23746257 | bp(GO:"protein secretion") association p(FPLX:HSP90) |
| pubmed:30740335 | p(HGNC:PPP1R15A) decreases p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30740335 | p(HGNC:PPP1R15A) increases path(MESH:"Protein Biosynthesis") |
| pubmed:30740335 | p(HGNC:PPP1R15A) decreases bp(GO:"synaptic signaling") |
| pubmed:26142647 | p(HGNC:PPP1R15A) regulates act(p(HGNC:PPP1CA)) |
| pubmed:30740335 | composite(p(HGNC:ERN1), p(HGNC:XBP1)) increases bp(GO:"JNK cascade") |
| pubmed:30740335 | p(HBP:"amyloid-beta aggregates") increases path(MESH:"Endoplasmic Reticulum Stress") |
| pubmed:30740335 | p(HGNC:FOXO1) increases path(MESH:Autophagy) |
| pubmed:30116051 | p(HGNC:FOXO1) increases bp(GO:macroautophagy) |
| pubmed:30740335 | a(CHEBI:salubrinal) decreases p(HGNC:PPP1R15A) |
| pubmed:28803412 | a(CHEBI:salubrinal) decreases bp(MESH:"Endoplasmic Reticulum Stress") |
| pubmed:28803412 | a(CHEBI:salubrinal) decreases a(CONSO:CONSO00093) |
| pubmed:30740335 | composite(a(CHEBI:salubrinal), p(HGNC:SNCA, pmod(HBP:misfolded))) increases p(HGNC:EIF2S1) |
| pubmed:30740335 | bp(GO:"negative regulation of dopamine receptor signaling pathway") association p(HGNC:EIF2AK3) |
| pubmed:30740335 | path(MESH:"Long-Term Potentiation") association p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30740335 | p(NCBIGENE:74018, frag("?")) increases path(MESH:"Endoplasmic Reticulum Stress") |
| pubmed:30740335 | a(CHEBI:Guanabenz) increases p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23746257 | a(CHEBI:Guanabenz) decreases act(p(FPLX:ADRA2)) |
| pubmed:23746257 | a(CHEBI:Guanabenz) decreases act(p(FPLX:EIF2B)) |
| pubmed:23746257 | a(CHEBI:Guanabenz) increases p(FPLX:EIF2B, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30740335 | a(PUBCHEM:9561611) decreases p(HGNC:EIF2AK3) |
| pubmed:30740335 | a(PUBCHEM:9561611) association a(MESH:"Neuroprotective Agents") |
| pubmed:30740335 | a(PUBCHEM:9561611) increases path(MESH:"Behavior and Behavior Mechanisms") |
| pubmed:30740335 | p(HGNC:USP14) increases deg(p(HGNC:HTT, pmod(HBP:misfolded))) |
| pubmed:30740335 | p(HGNC:USP14) increases p(HGNC:ERN1) |
| pubmed:25784053 | p(HGNC:USP14) decreases deg(p(HGNC:MAPT)) |
| pubmed:25784053 | p(HGNC:USP14) decreases deg(p(HGNC:TARDBP)) |
| pubmed:25784053 | p(HGNC:USP14) decreases act(p(FPLX:Proteasome)) |
| pubmed:26041011 | act(p(HGNC:USP14)) decreases act(complex(GO:"proteasome complex")) |
| pubmed:30740335 | p(HGNC:SIGMAR1) association bp(GO:"cellular response to stress") |
| pubmed:30740335 | p(HGNC:SIGMAR1) regulates bp(GO:"calcium-mediated signaling") |
| pubmed:30740335 | p(HGNC:SIGMAR1) regulates path(MESH:"Energy Metabolism") |
| pubmed:30740335 | p(HGNC:SIGMAR1) regulates bp(GO:"cell redox homeostasis") |
| pubmed:30740335 | p(HGNC:SIGMAR1) regulates path(MESH:"Unfolded Protein Response") |
| pubmed:30740335 | p(HGNC:SIGMAR1) regulates bp(GO:"cytokine-mediated signaling pathway") |
| pubmed:30740335 | p(DBSNP:rs2269577) association path(MESH:"Bipolar Disorder") |
| pubmed:27209302 | a(CHEBI:chloroquine) decreases act(a(MESH:Lysosomes)) |
| pubmed:27209302 | a(CHEBI:chloroquine) decreases deg(p(CONSO:"amyloid-beta fibrils")) |
| pubmed:25784053 | a(CHEBI:chloroquine) decreases bp(GO:autophagy) |
| pubmed:25784053 | a(CHEBI:chloroquine) increases a(CHEBI:N-retinylidene-N-retinylethanolamine) |
| pubmed:25784053 | a(CHEBI:chloroquine) increases p(HGNC:MAP1LC3A) |
| pubmed:25784053 | a(CHEBI:chloroquine) increases p(HGNC:SQSTM1) |
| pubmed:24027553 | a(CHEBI:chloroquine) increases p(HGNC:MAPT) |
| pubmed:24027553 | a(CHEBI:chloroquine) decreases deg(p(HGNC:MAPT)) |
| pubmed:27209302 | a(CHEBI:leupeptin) decreases act(a(MESH:Lysosomes)) |
| pubmed:27209302 | a(CHEBI:leupeptin) decreases deg(p(CONSO:"amyloid-beta fibrils")) |
| pubmed:23528736 | a(CHEBI:leupeptin) decreases act(p(FPLX:Proteasome)) |
| pubmed:23528736 | a(CHEBI:leupeptin) decreases deg(p(HGNC:MAPT)) |
| pubmed:27209302 | a(CHEBI:phosphoramidon) decreases p(HGNC:MME) |
| pubmed:27209302 | a(CHEBI:phosphoramidon) association deg(p(CONSO:"amyloid-beta fibrils")) |
| pubmed:27209302 | p(HGNC:TFEB) increases deg(p(CONSO:"amyloid-beta oligomers")) |
| pubmed:27209302 | p(HGNC:TFEB) increases bp(MESH:"Organelle Biogenesis") |
| pubmed:27209302 | p(HGNC:TFEB) increases bp(GO:"microglial cell activation") |
| pubmed:27209302 | tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) increases act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:26968346 | p(HGNC:TFEB, loc(GO:cytoplasm)) decreases act(p(HGNC:TFEB)) |
| pubmed:26968346 | tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) increases act(p(HGNC:TFEB)) |
| pubmed:30108137 | act(p(HGNC:TFEB)) negativeCorrelation p(HGNC:TFEB, loc(GO:cytoplasm)) |
| pubmed:30108137 | p(HGNC:TFEB, loc(GO:cytoplasm)) negativeCorrelation act(p(HGNC:TFEB)) |
| pubmed:30108137 | p(HGNC:TFEB) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:30108137 | p(HGNC:TFEB, loc(GO:nucleus)) increases act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:26702100 | act(p(HGNC:TFEB), ma(MESH:"Transcription, Genetic")) association p(HGNC:TFEB, loc(GO:nucleus)) |
| pubmed:26702100 | p(HGNC:TFEB, loc(GO:nucleus)) association act(p(HGNC:TFEB), ma(MESH:"Transcription, Genetic")) |
| pubmed:27209302 | p(HGNC:TFEB) increases a(MESH:Lysosomes) |
| pubmed:26968346 | p(HGNC:TFEB) increases a(MESH:Lysosomes) |
| pubmed:26968346 | p(HGNC:TFEB) increases tloc(a(MESH:Lysosomes), fromLoc(GO:"extracellular space"), toLoc(GO:cell)) |
| pubmed:26968346 | p(HGNC:TFEB) increases tloc(a(MESH:Lysosomes), fromLoc(GO:cell), toLoc(GO:"extracellular space")) |
| pubmed:26968346 | p(HGNC:TFEB) increases a(MESH:Lysosomes) |
| pubmed:26968346 | tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) increases a(MESH:Lysosomes) |
| pubmed:30108137 | p(HGNC:TFEB) increases a(MESH:Lysosomes) |
| pubmed:30108137 | p(HGNC:TFEB) regulates act(a(MESH:Lysosomes)) |
| pubmed:30108137 | p(HGNC:TFEB) increases a(MESH:Lysosomes) |
| pubmed:27299292 | p(HGNC:TFEB) increases a(MESH:Lysosomes) |
| pubmed:27299292 | act(p(HGNC:TFEB)) increases act(a(MESH:Lysosomes)) |
| pubmed:27299292 | p(HGNC:TFEB) increases a(MESH:Lysosomes) |
| pubmed:27299292 | p(HGNC:TFEB) increases a(MESH:Lysosomes) |
| pubmed:30108137 | act(p(HGNC:TFEB, loc(GO:nucleus))) decreases act(a(MESH:Lysosomes)) |
| pubmed:27209302 | p(HGNC:TFEB) increases bp(GO:"lysosomal protein catabolic process") |
| pubmed:26968346 | p(HGNC:TFEB) increases bp(GO:"lysosomal protein catabolic process") |
| pubmed:27209302 | act(p(HGNC:TFEB)) increases complex(g(HGNC:CLCN7), p(HGNC:TFEB)) |
| pubmed:26968346 | p(HGNC:TFEB) positiveCorrelation path(DOID:"renal carcinoma") |
| pubmed:26968346 | p(HGNC:TFEB) regulates bp(GO:autophagy) |
| pubmed:26968346 | p(HGNC:TFEB) increases bp(GO:autophagy) |
| pubmed:27299292 | act(p(HGNC:TFEB)) positiveCorrelation bp(GO:autophagy) |
| pubmed:27299292 | act(p(HGNC:TFEB)) increases bp(GO:autophagy) |
| pubmed:27299292 | act(p(HGNC:TFEB)) increases bp(GO:autophagy) |
| pubmed:27299292 | p(HGNC:TFEB) positiveCorrelation bp(GO:autophagy) |
| pubmed:27299292 | act(p(HGNC:TFEB)) increases bp(GO:autophagy) |
| pubmed:27299292 | p(HGNC:TFEB) increases bp(GO:autophagy) |
| pubmed:29758300 | p(HGNC:TFEB) regulates bp(GO:autophagy) |
| pubmed:29758300 | p(HGNC:TFEB) increases bp(GO:autophagy) |
| pubmed:29626319 | p(HGNC:TFEB) increases bp(GO:autophagy) |
| pubmed:26702100 | p(HGNC:TFEB) regulates bp(GO:autophagy) |
| pubmed:26702100 | act(p(HGNC:TFEB), ma(MESH:"Transcription, Genetic")) regulates bp(GO:autophagy) |
| pubmed:26968346 | p(HGNC:TFEB) regulates bp(GO:"membrane assembly") |
| pubmed:26968346 | p(HGNC:TFEB) positiveCorrelation bp(GO:"autophagosome organization") |
| pubmed:26968346 | p(HGNC:TFEB) positiveCorrelation bp(GO:"autophagosome-lysosome fusion") |
| pubmed:27299292 | act(p(HGNC:TFEB)) increases bp(GO:"autophagosome-lysosome fusion") |
| pubmed:26968346 | p(HGNC:TFEB) increases act(p(HGNC:MCOLN1)) |
| pubmed:27299292 | act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(HGNC:MCOLN1, loc(MESH:Lysosomes))) |
| pubmed:27299292 | p(HGNC:TFEB) increases p(HGNC:MCOLN1) |
| pubmed:26968346 | p(HGNC:TFEB) regulates bp(GO:"apoptotic cell clearance") |
| pubmed:26968346 | p(HGNC:TFEB) regulates bp(MESH:Metabolism) |
| pubmed:26968346 | p(HGNC:TFEB) increases bp(GO:"mRNA transcription") |
| pubmed:26968346 | p(HGNC:TFEB) decreases p(CONSO:"huntingtin aggregates") |
| pubmed:27299292 | p(HGNC:TFEB) decreases p(CONSO:"huntingtin aggregates") |
| pubmed:26968346 | p(HGNC:TFEB) increases p(HGNC:PPARGC1A) |
| pubmed:27299292 | act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases p(HGNC:PPARGC1A) |
| pubmed:26968346 | p(HGNC:TFEB) decreases act(p(HGNC:SNCA, var("?"))) |
| pubmed:26968346 | tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) decreases act(p(HGNC:SNCA, var("?"))) |
| pubmed:26968346 | tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) decreases bp(GO:"cell death") |
| pubmed:27299292 | p(HGNC:TFEB) decreases bp(GO:"cell death") |
| pubmed:26968346 | p(HGNC:TFEB) association bp(GO:mitophagy) |
| pubmed:27299292 | act(p(HGNC:TFEB)) increases bp(GO:mitophagy) |
| pubmed:26968346 | p(HGNC:TFEB) decreases act(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) |
| pubmed:30108137 | p(HGNC:TFEB) causesNoChange p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:27299292 | act(p(HGNC:TFEB)) increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) |
| pubmed:26968346 | p(HGNC:TFEB) decreases path(DOID:"neurodegenerative disease") |
| pubmed:27299292 | act(p(HGNC:TFEB)) negativeCorrelation path(DOID:"neurodegenerative disease") |
| pubmed:27299292 | p(HGNC:TFEB) negativeCorrelation path(DOID:"neurodegenerative disease") |
| pubmed:27299292 | p(HGNC:TFEB) decreases path(DOID:"neurodegenerative disease") |
| pubmed:26968346 | p(HGNC:TFEB) positiveCorrelation bp(GO:behavior) |
| pubmed:27299292 | p(HGNC:TFEB) positiveCorrelation bp(GO:behavior) |
| pubmed:27299292 | p(HGNC:TFEB) positiveCorrelation bp(GO:behavior) |
| pubmed:26968346 | p(HGNC:TFEB) increases p(HGNC:PTEN) |
| pubmed:27299292 | act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases p(HGNC:PTEN) |
| pubmed:29758300 | p(HGNC:TFEB) increases act(p(HGNC:PTEN)) |
| pubmed:26968346 | p(HGNC:TFEB) decreases path(MESH:"Plaque, Amyloid") |
| pubmed:27299292 | p(HGNC:TFEB) decreases path(MESH:"Plaque, Amyloid") |
| pubmed:27299292 | p(HGNC:TFEB) negativeCorrelation path(MESH:"Plaque, Amyloid") |
| pubmed:30116051 | p(HGNC:TFEB) decreases path(MESH:"Plaque, Amyloid") |
| pubmed:29626319 | p(HGNC:TFEB) decreases path(MESH:"Plaque, Amyloid") |
| pubmed:26968346 | p(HGNC:TFEB) increases act(p(MESH:Lysosomes)) |
| pubmed:26968346 | p(HGNC:TFEB, loc(GO:nucleus)) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:27299292 | p(HGNC:TFEB) increases tloc(a(CHEBI:amyloid-beta), fromLoc(GO:cytoplasm), toLoc(MESH:Astrocytes)) |
| pubmed:27299292 | p(HGNC:TFEB) decreases a(CHEBI:amyloid-beta) |
| pubmed:27299292 | p(HGNC:TFEB) decreases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | p(HGNC:TFEB) decreases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | p(HGNC:TFEB) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | p(HGNC:TFEB) regulates deg(a(CHEBI:amyloid-beta)) |
| pubmed:26968346 | p(HGNC:TFEB, loc(GO:nucleus)) increases p(MESH:Enzymes) |
| pubmed:30108137 | act(p(HGNC:TFEB)) association path(MESH:"Stress, Physiological") |
| pubmed:30108137 | act(p(HGNC:TFEB)) association p(CONSO:"protein aggregates") |
| pubmed:30108137 | p(HGNC:TFEB, loc(GO:nucleus)) association path(DOID:"lysosomal storage disease") |
| pubmed:30108137 | p(HGNC:TFEB) increases p(HGNC:LAMP1) |
| pubmed:30108137 | p(HGNC:TFEB) increases p(HGNC:LAMP1) |
| pubmed:30108137 | p(HGNC:TFEB) increases p(HGNC:LAMP1) |
| pubmed:30108137 | p(HGNC:TFEB) increases p(HGNC:CTSD) |
| pubmed:30108137 | p(HGNC:TFEB) increases p(HGNC:CTSD) |
| pubmed:30108137 | p(HGNC:TFEB) increases act(p(HGNC:CTSD), ma(GO:"peptidase activity")) |
| pubmed:30108137 | p(HGNC:TFEB) increases p(HGNC:CTSB) |
| pubmed:30108137 | p(HGNC:TFEB) increases complex(GO:"late endosome") |
| pubmed:30108137 | p(HGNC:TFEB) increases bp(GO:phagocytosis) |
| pubmed:30108137 | p(HGNC:TFEB) increases r(HGNC:LAMP1) |
| pubmed:30108137 | p(HGNC:TFEB) positiveCorrelation bp(GO:"lysosomal lumen acidification") |
| pubmed:27299292 | p(HGNC:TFEB) regulates bp(GO:"lysosomal lumen acidification") |
| pubmed:30108137 | p(HGNC:TFEB) increases p(CONSO:"Tau fibrils", loc(MESH:Lysosomes)) |
| pubmed:30108137 | p(HGNC:TFEB) increases p(CONSO:"Tau fibrils", loc(MESH:Lysosomes)) |
| pubmed:30108137 | p(HGNC:TFEB) increases deg(p(CONSO:"Tau fibrils")) |
| pubmed:30108137 | p(HGNC:TFEB) decreases p(CONSO:"Tau fibrils") |
| pubmed:30108137 | p(HGNC:TFEB, loc(MESH:Astrocytes)) causesNoChange bp(GO:"excitatory postsynaptic potential") |
| pubmed:30108137 | p(HGNC:TFEB, loc(MESH:Astrocytes)) causesNoChange bp(GO:"astrocyte activation") |
| pubmed:30108137 | p(HGNC:TFEB, loc(MESH:Astrocytes)) causesNoChange act(a(MESH:Neurons)) |
| pubmed:30108137 | p(HGNC:TFEB) causesNoChange p(HGNC:MAPT) |
| pubmed:30108137 | p(HGNC:TFEB) decreases p(HGNC:MAPT) |
| pubmed:30108137 | p(HGNC:TFEB) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30108137 | p(HGNC:TFEB) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30108137 | p(HGNC:TFEB) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30108137 | p(HGNC:TFEB, loc(MESH:Astrocytes)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30108137 | p(HGNC:TFEB) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29758300 | p(HGNC:TFEB) increases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:29626319 | p(HGNC:TFEB) regulates deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:30108137 | p(HGNC:TFEB) causesNoChange bp(GO:"reactive gliosis") |
| pubmed:30108137 | p(HGNC:TFEB) decreases bp(GO:"reactive gliosis") |
| pubmed:30108137 | p(HGNC:TFEB) causesNoChange bp(GO:"reactive gliosis") |
| pubmed:30108137 | p(HGNC:TFEB) increases complex(GO:"hippocampal mossy fiber to CA3 synapse") |
| pubmed:30108137 | p(HGNC:TFEB) decreases path(DOID:tauopathy) |
| pubmed:30108137 | p(HGNC:TFEB) decreases complex(GO:"neurofibrillary tangle") |
| pubmed:27299292 | p(HGNC:TFEB) decreases complex(GO:"neurofibrillary tangle") |
| pubmed:30108137 | p(HGNC:TFEB) decreases path(CONSO:"Pathological Tau Spreading") |
| pubmed:27299292 | p(HGNC:TFEB) regulates deg(a(CHEBI:hemoglobin)) |
| pubmed:27299292 | p(HGNC:TFEB) regulates deg(a(CHEBI:chitin)) |
| pubmed:27299292 | p(HGNC:TFEB) regulates bp(GO:exocytosis) |
| pubmed:27299292 | p(HGNC:TFEB) regulates bp(GO:endocytosis) |
| pubmed:27299292 | act(p(HGNC:TFEB)) increases bp(GO:"autophagosome assembly") |
| pubmed:27299292 | p(HGNC:TFEB) increases bp(GO:"autophagosome assembly") |
| pubmed:27299292 | p(HGNC:TFEB) positiveCorrelation bp(GO:"lipid catabolic process") |
| pubmed:27299292 | p(HGNC:TFEB) positiveCorrelation bp(GO:"lipid oxidation") |
| pubmed:27299292 | p(HGNC:TFEB) negativeCorrelation bp(GO:"lipid biosynthetic process") |
| pubmed:27299292 | p(HGNC:TFEB) positiveCorrelation bp(GO:"protein transport") |
| pubmed:27299292 | p(HGNC:TFEB) positiveCorrelation bp(GO:"protein maturation") |
| pubmed:27299292 | p(HGNC:TFEB) regulates bp(MESH:Proteostasis) |
| pubmed:27299292 | deg(p(HGNC:TFEB)) positiveCorrelation bp(GO:"chaperone-mediated autophagy") |
| pubmed:27299292 | p(HGNC:TFEB) association bp(GO:macroautophagy) |
| pubmed:30116051 | p(HGNC:TFEB) increases bp(GO:macroautophagy) |
| pubmed:30116051 | tloc(p(HGNC:TFEB), fromLoc(MESH:Cytoplasm), toLoc(MESH:"Cell Nucleus")) increases bp(GO:macroautophagy) |
| pubmed:27299292 | act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases p(HGNC:FLCN) |
| pubmed:27299292 | act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases p(HGNC:FNIP1) |
| pubmed:27299292 | act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases p(HGNC:FNIP2) |
| pubmed:27299292 | act(p(HGNC:TFEB)) association p(HGNC:EIF2AK3) |
| pubmed:27299292 | p(HGNC:TFEB) association p(HGNC:ATF4) |
| pubmed:27299292 | p(HGNC:TFEB) decreases p(CONSO:"alpha-synuclein oligomers") |
| pubmed:27299292 | p(HGNC:TFEB, loc(GO:nucleus)) increases bp(MESH:Neuroprotection) |
| pubmed:27299292 | act(p(HGNC:TFEB)) directlyIncreases bp(GO:"catabolic process") |
| pubmed:27299292 | p(HGNC:TFEB) increases bp(GO:"calcium ion regulated lysosome exocytosis") |
| pubmed:27299292 | p(HGNC:TFEB) increases bp(GO:"calcium ion regulated lysosome exocytosis") |
| pubmed:27299292 | p(HGNC:TFEB) increases bp(GO:"glycosaminoglycan catabolic process") |
| pubmed:27299292 | p(HGNC:TFEB) decreases bp(GO:"inflammatory response") |
| pubmed:27299292 | p(HGNC:TFEB) decreases bp(GO:"programmed cell death") |
| pubmed:27299292 | p(HGNC:TFEB) negativeCorrelation bp(GO:"programmed cell death") |
| pubmed:27299292 | act(p(HGNC:TFEB)) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pubmed:27299292 | p(HGNC:TFEB) decreases path(DOID:"Huntington's disease") |
| pubmed:27299292 | act(p(HGNC:TFEB)) increases p(HGNC:NFYA) |
| pubmed:27299292 | act(p(HGNC:TFEB)) increases bp(GO:"nuclear protein quality control by the ubiquitin-proteasome system") |
| pubmed:27299292 | p(HGNC:TFEB) decreases path(CONSO:"mitochondrial dysfunction") |
| pubmed:27299292 | p(HGNC:TFEB) positiveCorrelation bp(GO:"neuron-neuron synaptic transmission") |
| pubmed:27299292 | act(p(HGNC:TFEB)) increases deg(p(HGNC:MAPT, pmod(CONSO:misfolded))) |
| pubmed:27299292 | p(HGNC:TFEB) increases deg(p(HGNC:APP, var("?"))) |
| pubmed:27299292 | p(HGNC:TFEB) decreases p(HGNC:GSK3B) |
| pubmed:27299292 | p(HGNC:TFEB) negativeCorrelation path(DOID:neuropathy) |
| pubmed:27299292 | p(HGNC:TFEB) increases deg(p(HGNC:SERPINA1, var("?"))) |
| pubmed:27299292 | p(HGNC:TFEB) negativeCorrelation path(MESH:Fibrosis) |
| pubmed:27299292 | p(HGNC:TFEB) decreases p(HGNC:SERPINA1, pmod(CONSO:misfolded)) |
| pubmed:27299292 | p(HGNC:TFEB) decreases p(HGNC:SERPINA1, pmod(CONSO:"protein aggregates")) |
| pubmed:29758300 | p(HGNC:TFEB) regulates a(GO:lysosome) |
| pubmed:29626319 | p(HGNC:TFEB) increases act(a(GO:lysosome)) |
| pubmed:29626319 | p(HGNC:TFEB) increases act(a(GO:lysosome)) |
| pubmed:26702100 | act(p(HGNC:TFEB), ma(MESH:"Transcription, Genetic")) regulates a(GO:lysosome) |
| pubmed:26702100 | p(HGNC:TFEB) increases a(GO:lysosome) |
| pubmed:29758300 | p(HGNC:TFEB) association path(MESH:"Alzheimer Disease") |
| pubmed:28803412 | p(HGNC:TFEB) decreases a(CONSO:CONSO00093) |
| pubmed:30108137 | act(p(HGNC:TFEB, loc(GO:nucleus))) increases a(CONSO:"protein aggregates") |
| pubmed:29626319 | p(HGNC:TFEB) regulates deg(a(MESH:"Neurofibrillary Tangles")) |
| pubmed:28669544 | p(HGNC:TFEB) regulates path(MESH:"Organelle Biogenesis") |
| pubmed:30837838 | p(HGNC:TFEB) regulates path(MESH:Autophagy) |
| pubmed:30837838 | p(HGNC:TFEB) association p(HGNC:TARDBP) |
| pubmed:26702100 | p(HGNC:TFEB) association path(MESH:"Neurodegenerative Diseases") |
| pubmed:26702100 | p(HGNC:TFEB, loc(GO:lysosome)) association p(HGNC:RRAGA) |
| pubmed:26702100 | p(HGNC:TFEB) increases p(HGNC:MAP1LC3B) |
| pubmed:26702100 | p(HGNC:TFEB) increases a(GO:autophagosome) |
| pubmed:27209302 | r(HGNC:TFEB) increases bp(GO:"microglial cell activation") |
| pubmed:26968346 | r(HGNC:TFEB) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:26968346 | r(HGNC:TFEB) increases p(MESH:Enzymes) |
| pubmed:30108137 | r(HGNC:TFEB) association path(DOID:dementia) |
| pubmed:30108137 | r(HGNC:TFEB) negativeCorrelation bp(GO:cognition) |
| pubmed:30108137 | r(HGNC:TFEB) decreases bp(GO:cognition) |
| pubmed:30108137 | r(HGNC:TFEB) positiveCorrelation a(CONSO:"Braak_Stage VI") |
| pubmed:30108137 | r(HGNC:TFEB) increases p(HGNC:TFEB) |
| pubmed:27299292 | r(HGNC:TFEB) increases p(HGNC:TFEB) |
| pubmed:30108137 | r(HGNC:TFEB) positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pubmed:30108137 | r(HGNC:TFEB) increases path(MESH:Dementia) |
| pubmed:27209302 | p(HGNCGENEFAMILY:"MTOR complex 1", pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(HGNCGENEFAMILY:"MTOR complex 1")) |
| pubmed:27209302 | p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) decreases bp(GO:"microglial cell activation") |
| pubmed:27209302 | p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) decreases bp(GO:"microglial cell activation") |
| pubmed:27209302 | p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) decreases act(p(HGNC:TFEB)) |
| pubmed:27209302 | p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) increases p(CONSO:"amyloid-beta aggregates") |
| pubmed:27209302 | p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) increases path(MESH:"Plaque, Amyloid") |
| pubmed:27209302 | p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) decreases a(MESH:Lysosomes) |
| pubmed:27209302 | p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) decreases act(a(MESH:Lysosomes)) |
| pubmed:27209302 | p(HGNC:HDAC4) decreases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:27209302 | p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation", Lys, 116)) regulates act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:27209302 | p(HGNC:TFEB, var("p.Lys116Arg")) increases deg(p(CONSO:"amyloid-beta fibrils")) |
| pubmed:27209302 | p(HGNC:TFEB, var("p.Lys116Arg")) causesNoChange deg(p(CONSO:"amyloid-beta fibrils")) |
| pubmed:27209302 | p(HGNC:TFEB, var("p.Lys116Arg")) increases a(MESH:Lysosomes) |
| pubmed:27209302 | p(HGNC:TFEB, var("p.Lys116Arg")) causesNoChange a(MESH:Lysosomes) |
| pubmed:27209302 | p(HGNC:TFEB, var("p.Lys116Arg")) causesNoChange act(a(MESH:Lysosomes)) |
| pubmed:27209302 | p(HGNC:TFEB, var("p.Lys116Arg")) increases act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:27209302 | p(HGNC:TFEB, var("p.Lys116Arg")) increases act(p(HGNC:TFEB)) |
| pubmed:27209302 | p(HGNC:TFEB, var("p.Lys116Arg")) increases deg(p(CONSO:"amyloid-beta aggregates")) |
| pubmed:27209302 | composite(p(HGNC:SIRT1), p(HGNC:TFEB)) increases complex(p(HGNC:SIRT1), p(HGNC:TFEB)) |
| pubmed:27209302 | p(HGNC:SIRT1, var("?")) increases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:27209302 | p(HGNC:SIRT1, var("?")) decreases act(p(HGNC:SIRT1)) |
| pubmed:27209302 | p(HGNC:SIRT1, var("?")) decreases act(p(HGNC:SIRT1)) |
| pubmed:27209302 | p(HGNC:SIRT1, var("?")) increases a(MESH:Lysosomes) |
| pubmed:27209302 | p(HGNC:SIRT6) causesNoChange p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:27209302 | p(HGNC:SIRT6) decreases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:27209302 | p(HGNC:SIRT7) causesNoChange p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:27209302 | p(HGNC:SIRT7) decreases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:27209302 | composite(a(CHEBI:nicotinamide), a(MESH:Lysosomes)) decreases a(MESH:Lysosomes) |
| pubmed:27209302 | complex(g(HGNC:CLCN7), p(HGNC:TFEB)) increases p(HGNC:CLCN7) |
| pubmed:26968346 | path(DOID:"renal carcinoma") positiveCorrelation p(HGNC:TFEB) |
| pubmed:27299292 | path(DOID:"renal carcinoma") positiveCorrelation path(DOID:"Birt-Hogg-Dube syndrome") |
| pubmed:26968346 | bp(GO:"autophagosome organization") positiveCorrelation p(HGNC:TFEB) |
| pubmed:26968346 | act(p(HGNC:MCOLN1)) increases tloc(a(MESH:Lysosomes), fromLoc(GO:cell), toLoc(GO:"extracellular space")) |
| pubmed:26968346 | p(HGNC:MCOLN1) decreases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26968346 | p(HGNC:MCOLN1) increases complex(GO:"calcineurin complex") |
| pubmed:27299292 | act(p(HGNC:MCOLN1, loc(MESH:Lysosomes))) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30116051 | act(p(HGNC:MCOLN1)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:Lysosomes), toLoc(MESH:Cytoplasm)) |
| pubmed:27299292 | p(HGNC:MCOLN1) increases bp(GO:"calcium ion import") |
| pubmed:30116051 | act(p(HGNC:MCOLN1)) increases bp(GO:"lysosomal lumen acidification") |
| pubmed:30116051 | act(p(HGNC:MCOLN1)) decreases a(CHEBI:amyloid-beta) |
| pubmed:26968346 | bp(GO:"response to starvation") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:26968346 | bp(GO:"response to nutrient") increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 142)) |
| pubmed:26968346 | bp(GO:"response to nutrient") increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 211)) |
| pubmed:26968346 | bp(GO:"response to nutrient") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:22908190 | bp(GO:"response to nutrient") regulates p(HGNC:MTOR) |
| pubmed:27299292 | p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 142)) decreases act(p(HGNC:TFEB)) |
| pubmed:27299292 | p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 142)) increases p(HGNC:TFEB, loc(GO:cytoplasm)) |
| pubmed:27299292 | p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 142)) decreases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) |
| pubmed:27299292 | p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 211)) decreases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) |
| pubmed:27299292 | p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 211)) increases composite(p(HGNC:TFEB), p(HGNC:YWHAQ)) |
| pubmed:26968346 | p(HGNC:TFEB, var("p.Ser142Ala")) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:26968346 | p(HGNC:TFEB, var("p.Ser211Ala")) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:26702100 | p(HGNC:TFEB, var("p.Ser211Ala")) decreases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26702100 | p(HGNC:TFEB, var("p.Ser211Ala")) decreases complex(p(HGNC:TFEB), p(HGNCGENEFAMILY:"14-3-3 phospho-serine/phospho-threonine binding proteins")) |
| pubmed:26968346 | complex(p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")), p(HGNCGENEFAMILY:"14-3-3 phospho-serine/phospho-threonine binding proteins")) increases p(HGNCGENEFAMILY:"14-3-3 phospho-serine/phospho-threonine binding proteins", loc(GO:cytoplasm)) |
| pubmed:30108137 | p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) increases p(HGNC:TFEB, loc(GO:cytoplasm)) |
| pubmed:27299292 | p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) increases p(HGNC:TFEB, loc(GO:cytosol)) |
| pubmed:29758300 | p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(HGNC:TFEB)) |
| pubmed:26702100 | p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) increases complex(p(HGNC:TFEB), p(HGNCGENEFAMILY:"14-3-3 phospho-serine/phospho-threonine binding proteins")) |
| pubmed:26968346 | composite(a(MESH:"Amino Acids"), p(MESH:"Vacuolar Proton-Translocating ATPases")) regulates act(complex(GO:"Ragulator complex"), ma(GO:"GTPase activity")) |
| pubmed:26968346 | act(complex(GO:"Ragulator complex"), ma(GO:"GTPase activity")) increases tloc(p(HGNCGENEFAMILY:"MTOR complex 1"), fromLoc(GO:cytoplasm), toLoc(GO:"lysosomal membrane")) |
| pubmed:27299292 | complex(GO:"Ragulator complex") increases tloc(p(HGNCGENEFAMILY:"MTOR complex 1"), fromLoc(GO:cytoplasm), toLoc(GO:"plasma membrane")) |
| pubmed:27299292 | complex(GO:"Ragulator complex") increases tloc(p(HGNCGENEFAMILY:"MTOR complex 1"), fromLoc(GO:cytoplasm), toLoc(GO:"plasma membrane")) |
| pubmed:27299292 | complex(GO:"Ragulator complex") association act(p(HGNCGENEFAMILY:"MTOR complex 1")) |
| pubmed:27299292 | act(complex(GO:"Ragulator complex")) increases p(HGNC:TFEB, loc(GO:cytoplasm)) |
| pubmed:26702100 | complex(GO:"Ragulator complex") regulates act(p(HGNC:MTOR)) |
| pubmed:26968346 | complex(p(HGNC:TFEB), p(HGNCGENEFAMILY:"MTOR complex 1"), loc(GO:"lysosomal membrane")) increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26968346 | complex(p(HGNC:TFEB), p(HGNCGENEFAMILY:"MTOR complex 1"), loc(GO:"lysosomal membrane")) increases p(HGNC:TFEB, loc(GO:cytoplasm)) |
| pubmed:26968346 | a(CHEBI:"torin 1") decreases p(HGNCGENEFAMILY:"MTOR complex 1") |
| pubmed:30108137 | a(CHEBI:"torin 1") decreases p(HGNCGENEFAMILY:"MTOR complex 1") |
| pubmed:26968346 | a(CHEBI:"torin 1") increases p(HGNC:TFEB, loc(GO:nucleus)) |
| pubmed:30108137 | a(CHEBI:"torin 1") increases p(HGNC:TFEB, loc(GO:nucleus)) |
| pubmed:26702100 | a(CHEBI:"torin 1") increases p(HGNC:TFEB, loc(GO:lysosome)) |
| pubmed:26702100 | a(CHEBI:"torin 1") increases p(HGNC:TFEB, loc(GO:nucleus)) |
| pubmed:30108137 | a(CHEBI:"torin 1") increases composite(p(HGNC:LAMP1), p(HGNC:TFEB)) |
| pubmed:30108137 | a(CHEBI:"torin 1") decreases act(p(FPLX:mTORC1)) |
| pubmed:26702100 | a(CHEBI:"torin 1") isA a(CHEBI:"mTOR inhibitor") |
| pubmed:26968346 | complex(a(MESH:"Transcription Factors"), r(HGNC:TFEB)) increases p(HGNC:TFEB) |
| pubmed:26968346 | composite(a(CHEBI:"calcium(2+)"), p(HGNC:MCOLN1)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:lysosome), toLoc(GO:cytoplasm)) |
| pubmed:26968346 | complex(p(HGNC:HTT), p(HGNC:SQSTM1)) increases bp(GO:"selective autophagy") |
| pubmed:26968346 | bp(GO:"selective autophagy") increases deg(p(HGNC:HTT)) |
| pubmed:26968346 | bp(GO:"selective autophagy") association p(HGNC:HTT) |
| pubmed:26968346 | composite(p(HGNC:HTT), p(HGNC:ULK1)) increases bp(GO:autophagy) |
| pubmed:26968346 | bp(GO:"protein phosphorylation") regulates bp(GO:"chaperone-mediated autophagy") |
| pubmed:30985105 | bp(GO:"protein phosphorylation") association p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:30985105 | bp(GO:"protein phosphorylation") association p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:26968346 | p(HGNC:HSPA8) increases deg(p(HGNC:HTT)) |
| pubmed:25437566 | p(HGNC:HSPA8) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:25437566 | p(HGNC:HSPA8) increases bp(GO:"protein folding") |
| pubmed:25437566 | p(HGNC:HSPA8) increases a(CONSO:"huntingtin aggregates") |
| pubmed:29758300 | p(HGNC:HSPA8) increases deg(p(HGNC:MAPT)) |
| pubmed:21882945 | act(p(HGNC:HSPA8), ma(GO:"ATPase activity")) decreases deg(p(HGNC:MAPT)) |
| pubmed:21882945 | act(p(HGNC:HSPA8)) increases p(HGNC:MAPT) |
| pubmed:18930136 | p(HGNC:HSPA8) association bp(GO:"chaperone-mediated autophagy") |
| pubmed:18930136 | p(HGNC:HSPA8) increases complex(a(MESH:Proteins), p(HGNC:HSPA8)) |
| pubmed:24706768 | p(HGNC:HSPA8) increases bp(GO:"clathrin-dependent endocytosis") |
| pubmed:24706768 | p(HGNC:HSPA8) increases bp(GO:"clathrin-dependent endocytosis") |
| pubmed:24706768 | p(HGNC:HSPA8) increases bp(GO:"clathrin coat disassembly") |
| pubmed:21882945 | p(HGNC:HSPA8) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:18500754 | p(HGNC:HSPA8) association p(CONSO:"microtubule-binding region") |
| pubmed:18500754 | act(p(HGNC:HSPA8)) negativeCorrelation act(complex(GO:microtubule)) |
| pubmed:17954934 | p(HGNC:HSPA8) isA complex(p(HGNC:BAG1), p(HGNC:HSPA8), p(HGNC:MAPT)) |
| pubmed:26968346 | p(HGNC:LAMP2) increases deg(p(HGNC:HTT)) |
| pubmed:30562574 | p(HGNC:LAMP2, loc(GO:"lysosomal membrane")) increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) |
| pubmed:18930136 | p(HGNC:LAMP2) increases tloc(a(MESH:Proteins), fromLoc(GO:intracellular), toLoc(GO:lysosome)) |
| pubmed:30562574 | p(HGNC:LAMP2) regulates bp(GO:"chaperone-mediated autophagy") |
| pubmed:30562574 | p(HGNC:LAMP2, loc(GO:cytoplasm)) decreases bp(GO:"chaperone-mediated autophagy") |
| pubmed:30562574 | p(HGNC:LAMP2, loc(GO:"lysosomal membrane")) increases bp(GO:"chaperone-mediated autophagy") |
| pubmed:30562574 | p(HGNC:LAMP2) increases bp(GO:"chaperone-mediated autophagy") |
| pubmed:30116051 | p(HGNC:LAMP2) increases bp(GO:"chaperone-mediated autophagy") |
| pubmed:30562574 | p(HGNC:LAMP2) negativeCorrelation bp(GO:aging) |
| pubmed:30562574 | p(HGNC:LAMP2) regulates a(MESH:Proteome) |
| pubmed:30562574 | p(HGNC:LAMP2) increases bp(GO:"lysosomal protein catabolic process") |
| pubmed:30562574 | p(HGNC:LAMP2) causesNoChange bp(GO:macroautophagy) |
| pubmed:30562574 | p(HGNC:LAMP2) causesNoChange p(HGNC:MAP1LC3A, pmod(GO:"protein lipidation")) |
| pubmed:30562574 | p(HGNC:LAMP2) causesNoChange p(HGNC:SQSTM1) |
| pubmed:30562574 | p(HGNC:LAMP2) causesNoChange path(MESH:"Cytotoxicity, Immunologic") |
| pubmed:30562574 | p(HGNC:LAMP2) causesNoChange bp(GO:"cell death") |
| pubmed:30562574 | p(HGNC:LAMP2) causesNoChange p(HGNC:TUBB3) |
| pubmed:30562574 | p(HGNC:LAMP2) causesNoChange p(HGNC:TUBB3) |
| pubmed:30562574 | p(HGNC:LAMP2) causesNoChange p(HGNC:MAP2) |
| pubmed:30562574 | p(HGNC:LAMP2) increases p(HGNC:MAP2) |
| pubmed:30562574 | p(HGNC:LAMP2) decreases p(HGNC:GAPDH) |
| pubmed:30562574 | p(HGNC:LAMP2) decreases p(HGNC:PHB) |
| pubmed:30562574 | deg(p(HGNC:LAMP2)) causesNoChange r(HGNC:PARK7) |
| pubmed:30562574 | deg(p(HGNC:LAMP2)) increases deg(p(HGNC:PARK7)) |
| pubmed:30562574 | p(HGNC:LAMP2) increases p(HGNC:PARK7) |
| pubmed:30562574 | deg(p(HGNC:LAMP2)) causesNoChange r(HGNC:DPYSL2) |
| pubmed:30562574 | deg(p(HGNC:LAMP2)) increases deg(p(HGNC:DPYSL2)) |
| pubmed:30562574 | p(HGNC:LAMP2) increases p(HGNC:DPYSL2) |
| pubmed:30562574 | p(HGNC:LAMP2) increases p(HGNC:DPYSL2) |
| pubmed:30562574 | p(HGNC:LAMP2) increases p(HGNC:DPYSL2) |
| pubmed:30562574 | act(p(HGNC:LAMP2)) regulates a(GO:dendrite) |
| pubmed:30562574 | act(p(HGNC:LAMP2)) causesNoChange bp(GO:"neuron projection development") |
| pubmed:30116051 | p(HGNC:LAMP2) increases deg(p(HGNC:SNCA)) |
| pubmed:26968346 | a(CHEBI:Temsirolimus) positiveCorrelation bp(GO:autophagy) |
| pubmed:29626319 | a(CHEBI:Temsirolimus) increases bp(GO:autophagy) |
| pubmed:26968346 | a(CHEBI:Temsirolimus) increases deg(p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) |
| pubmed:27299292 | a(CHEBI:Temsirolimus) increases a(CHEBI:sirolimus) |
| pubmed:27299292 | a(CHEBI:Temsirolimus) decreases act(p(HGNCGENEFAMILY:"MTOR complex 1")) |
| pubmed:27299292 | a(CHEBI:Temsirolimus) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:27299292 | a(CHEBI:Temsirolimus) increases bp(MESH:Neuroprotection) |
| pubmed:29758300 | a(CHEBI:Temsirolimus) increases bp(GO:macroautophagy) |
| pubmed:30116051 | a(CHEBI:Temsirolimus) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29626319 | a(CHEBI:Temsirolimus) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30116051 | a(CHEBI:Temsirolimus) decreases a(CONSO:"huntingtin aggregates") |
| pubmed:30116051 | a(CHEBI:Temsirolimus) increases bp(GO:"motor behavior") |
| pubmed:30116051 | a(CHEBI:Temsirolimus) decreases a(CONSO:"alpha-synuclein aggregates") |
| pubmed:30116051 | a(CHEBI:Temsirolimus) decreases bp(HP:Neurodegeneration) |
| pubmed:30116051 | a(CHEBI:Temsirolimus) decreases p(HGNC:ATXN3, var("?")) |
| pubmed:29626319 | a(CHEBI:Temsirolimus) decreases a(CHEBI:amyloid-beta) |
| pubmed:26968346 | bp(GO:"nervous system process") positiveCorrelation p(HGNC:PPARGC1A) |
| pubmed:26968346 | bp(GO:"regulation of ER to Golgi vesicle-mediated transport") negativeCorrelation p(CONSO:"alpha-synuclein aggregates") |
| pubmed:26968346 | bp(GO:"regulation of ER to Golgi vesicle-mediated transport") positiveCorrelation bp(GO:autophagy) |
| pubmed:26968346 | bp(GO:"regulation of ER to Golgi vesicle-mediated transport") association p(HGNC:RAB1A) |
| pubmed:26968346 | p(HGNC:RAB1A) association bp(GO:"regulation of ER to Golgi vesicle-mediated transport") |
| pubmed:26968346 | p(HGNC:RAB1A) regulates bp(GO:macroautophagy) |
| pubmed:26968346 | p(HGNC:RAB1A) decreases p(CONSO:"alpha-synuclein aggregates") |
| pubmed:26968346 | p(HGNC:RAB1A) positiveCorrelation bp(GO:autophagy) |
| pubmed:27181519 | p(HGNC:RAB1A) increases bp(GO:autophagy) |
| pubmed:25784053 | p(HGNC:RAB1A) increases bp(GO:"autophagosome assembly") |
| pubmed:29238289 | p(HGNC:RAB1A) association tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27181519 | p(HGNC:RAB1A) increases deg(p(HGNC:FUS, pmod(CONSO:"protein aggregation"))) |
| pubmed:27181519 | p(HGNC:RAB1A) association g(HGNC:C9orf72) |
| pubmed:27299292 | bp(GO:macroautophagy) association p(HGNC:TFEB) |
| pubmed:30562574 | bp(GO:macroautophagy) increases tloc(a(MESH:"Cytoplasmic Vesicles"), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) |
| pubmed:30562574 | bp(GO:macroautophagy) negativeCorrelation bp(GO:"chaperone-mediated autophagy") |
| pubmed:29758300 | bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25784053 | bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | bp(GO:macroautophagy) increases deg(a(CONSO:"protein aggregates")) |
| pubmed:29758300 | bp(GO:macroautophagy) increases deg(a(CONSO:"protein aggregates")) |
| pubmed:27181519 | bp(GO:macroautophagy) increases deg(a(CONSO:"protein aggregates")) |
| pubmed:29758300 | bp(GO:macroautophagy) regulates bp(GO:"amyloid-beta metabolic process") |
| pubmed:29758300 | bp(GO:macroautophagy) negativeCorrelation a(CHEBI:amyloid-beta) |
| pubmed:29758300 | bp(GO:macroautophagy) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29758300 | bp(GO:macroautophagy) regulates a(CHEBI:amyloid-beta) |
| pubmed:29758300 | bp(GO:macroautophagy) increases tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:29758300 | bp(GO:macroautophagy) increases tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:29758300 | bp(GO:macroautophagy) association p(HGNC:BECN1) |
| pubmed:29758300 | bp(GO:macroautophagy) increases path(MESH:"Plaque, Amyloid") |
| pubmed:29758300 | bp(GO:macroautophagy) increases deg(a(CONSO:"Tau aggregates")) |
| pubmed:29758300 | bp(GO:macroautophagy) increases deg(a(CHEBI:triglyceride)) |
| pubmed:29758300 | bp(GO:macroautophagy) negativeCorrelation path(MESH:"Parkinson Disease") |
| pubmed:29758300 | bp(GO:macroautophagy) negativeCorrelation path(MESH:"Niemann-Pick Disease, Type C") |
| pubmed:29758300 | bp(GO:macroautophagy) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:29758300 | bp(GO:macroautophagy) negativeCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") |
| pubmed:29758300 | bp(GO:macroautophagy) negativeCorrelation path(MESH:"Spastic Paraplegia, Hereditary") |
| pubmed:22908190 | bp(GO:macroautophagy) increases a(GO:autophagosome) |
| pubmed:22908190 | bp(GO:macroautophagy) increases deg(p(HGNC:MAPT, frag("?"))) |
| pubmed:18930136 | bp(GO:macroautophagy) increases bp(GO:"autophagosome-lysosome fusion") |
| pubmed:18930136 | bp(GO:macroautophagy) increases deg(p(HGNC:SNCA)) |
| pubmed:30116051 | bp(GO:macroautophagy) increases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:29024336 | bp(GO:macroautophagy) increases deg(p(MGI:Mapt)) |
| pubmed:29024336 | bp(GO:macroautophagy) decreases deg(p(MGI:Mapt)) |
| pubmed:29024336 | bp(GO:macroautophagy) increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) |
| pubmed:29024336 | bp(GO:macroautophagy) decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) |
| pubmed:29024336 | bp(GO:macroautophagy) causesNoChange deg(p(MGI:Mapt, var("p.Pro301Leu"))) |
| pubmed:29024336 | bp(GO:macroautophagy) increases deg(a(MESH:Proteins)) |
| pubmed:26751493 | bp(GO:macroautophagy) decreases p(HGNC:MAPT) |
| pubmed:27181519 | bp(GO:macroautophagy) isA bp(GO:"selective autophagy") |
| pubmed:27181519 | bp(GO:macroautophagy) increases bp(GO:"ribonucleoprotein complex disassembly") |
| pubmed:27181519 | bp(GO:macroautophagy) increases deg(complex(GO:"cytoplasmic stress granule")) |
| pubmed:26968346 | p(HGNC:MEF2D) increases bp(GO:"neuron cellular homeostasis") |
| pubmed:26968346 | p(MESH:Glucosylceramidase, var("?")) association path(DOID:"Gaucher's disease") |
| pubmed:26968346 | p(MESH:Glucosylceramidase) decreases p(CONSO:"alpha-synuclein aggregates") |
| pubmed:26968346 | p(MESH:Glucosylceramidase) decreases a(MESH:"Toxic Actions") |
| pubmed:26968346 | act(p(MESH:Glucosylceramidase)) decreases act(p(HGNC:SNCA, var("?"))) |
| pubmed:26968346 | act(p(MESH:Glucosylceramidase)) positiveCorrelation bp(GO:behavior) |
| pubmed:26968346 | path(DOID:"Gaucher's disease") association p(MESH:Glucosylceramidase, var("?")) |
| pubmed:27299292 | path(DOID:"Gaucher's disease") positiveCorrelation p(HGNC:GBA, var("p.Leu444Pro")) |
| pubmed:26968346 | bp(GO:"regulation of glucosylceramidase activity") negativeCorrelation p(HGNC:SNCA) |
| pubmed:26968346 | composite(p(HGNC:SNCA), p(HGNC:TFEB), loc(GO:"Lewy body")) increases p(HGNC:TFEB, loc(GO:cytoplasm)) |
| pubmed:26968346 | composite(p(HGNC:SNCA), p(HGNC:TFEB), loc(GO:"Lewy body")) decreases act(p(HGNC:TFEB)) |
| pubmed:26968346 | a(CHEBI:trehalose) increases act(p(HGNC:TFEB)) |
| pubmed:26968346 | a(CHEBI:trehalose) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:26968346 | a(CHEBI:trehalose) decreases bp(GO:"cell death") |
| pubmed:26968346 | a(CHEBI:trehalose) decreases p(CONSO:PrPSc) |
| pubmed:26968346 | a(PUBCHEM:90479739) increases act(p(HGNC:TFEB)) |
| pubmed:27299292 | a(PUBCHEM:90479739) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) |
| pubmed:27299292 | a(PUBCHEM:90479739) increases act(p(HGNC:TFEB)) |
| pubmed:26968346 | a(PUBCHEM:90479739) increases deg(p(CONSO:"alpha-synuclein aggregates")) |
| pubmed:27299292 | a(PUBCHEM:90479739) decreases path(DOID:"Niemann-Pick disease type C1") |
| pubmed:27299292 | a(PUBCHEM:90479739) decreases path(DOID:"Niemann-Pick disease type C2") |
| pubmed:26968346 | a(PUBCHEM:277318041) increases act(p(HGNC:PINK1), ma(go:0016301 ! "kinase activity")) |
| pubmed:26968346 | p(HGNC:PRKN, var("p.Gln311?")) increases path(CONSO:"mitochondrial dysfunction") |
| pubmed:26968346 | composite(p(HGNC:PPARGC1A), p(HGNC:TFEB)) increases bp(GO:mitophagy) |
| pubmed:26968346 | composite(p(HGNC:PPARGC1A), p(HGNC:TFEB)) increases a(MESH:Mitochondria) |
| pubmed:26968346 | p(HGNC:ZNF746) decreases composite(p(HGNC:PPARGC1A), p(HGNC:TFEB)) |
| pubmed:26968346 | bp(GO:"proton-transporting V-type ATPase complex assembly") negativeCorrelation p(HGNC:PSEN1, var("?")) |
| pubmed:30108137 | bp(GO:"lysosomal lumen acidification") positiveCorrelation p(HGNC:TFEB) |
| pubmed:26968346 | bp(GO:"endomembrane system organization") positiveCorrelation p(HGNC:PSEN1) |
| pubmed:26968346 | bp(GO:"endomembrane system organization") positiveCorrelation p(HGNC:PSEN2) |
| pubmed:26968346 | p(HGNC:PTEN) decreases p(HGNC:AKT1) |
| pubmed:26968346 | p(HGNC:PTEN) decreases p(HGNC:MTOR) |
| pubmed:27299292 | act(p(HGNC:PTEN)) increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) |
| pubmed:27299292 | act(p(HGNC:PTEN)) increases deg(p(HGNC:MAPT, pmod(CONSO:misfolded))) |
| pubmed:27299292 | act(p(HGNC:PTEN)) increases bp(GO:autophagy) |
| pubmed:27299292 | act(p(HGNC:PTEN)) increases bp(GO:"protein catabolic process") |
| pubmed:29758300 | p(HGNC:PTEN) increases bp(GO:macroautophagy) |
| pubmed:26968346 | act(p(MESH:Lysosomes)) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:26195256 | act(p(MESH:Lysosomes)) increases deg(p(HGNC:MAPT)) |
| pubmed:26968346 | m(MIRBASE:hsa-mir-128-1) decreases p(HGNC:TFEB) |
| pubmed:26968346 | m(MIRBASE:hsa-mir-128-1) decreases p(HGNC:TFEB, loc(GO:nucleus)) |
| pubmed:27299292 | m(MIRBASE:hsa-mir-128-1) decreases p(HGNC:TFEB) |
| pubmed:27299292 | m(MIRBASE:hsa-mir-128-1) decreases p(HGNC:TFEB) |
| pubmed:27299292 | m(MIRBASE:hsa-mir-128-1) decreases p(HGNC:TFEB) |
| pubmed:26968346 | m(MIRBASE:hsa-mir-128-1) decreases r(HGNC:TFEB) |
| pubmed:27299292 | act(m(MIRBASE:hsa-mir-128-1), ma(GO:"mRNA 3'-UTR binding")) increases complex(m(MIRBASE:hsa-mir-128-1), r(HGNC:TFEB)) |
| pubmed:27299292 | m(MIRBASE:hsa-mir-128-1) decreases deg(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pubmed:27299292 | m(MIRBASE:hsa-mir-128-1) positiveCorrelation path(DOID:"Parkinson's disease") |
| pubmed:26968346 | m(MIRBASE:hsa-mir-128-2) decreases p(HGNC:TFEB) |
| pubmed:26968346 | m(MIRBASE:hsa-mir-128-2) decreases p(HGNC:TFEB, loc(GO:nucleus)) |
| pubmed:27299292 | m(MIRBASE:hsa-mir-128-2) decreases p(HGNC:TFEB) |
| pubmed:26968346 | m(MIRBASE:hsa-mir-128-2) decreases r(HGNC:TFEB) |
| pubmed:27299292 | act(m(MIRBASE:hsa-mir-128-2), ma(GO:"mRNA 3'-UTR binding")) increases complex(m(MIRBASE:hsa-mir-128-2), r(HGNC:TFEB)) |
| pubmed:26968346 | path(MESH:"Late Onset Disorders") increases m(MIRBASE:hsa-mir-128-1) |
| pubmed:26968346 | path(MESH:"Late Onset Disorders") increases m(MIRBASE:hsa-mir-128-2) |
| pubmed:26968346 | path(MESH:"Late Onset Disorders") decreases deg(a(CHEBI:amyloid-beta)) |
| pubmed:26968346 | path(MESH:"Late Onset Disorders") decreases p(MESH:Enzymes) |
| pubmed:26968346 | p(HGNC:PSEN1, var("p.Ala246Glu")) increases bp(GO:"lysosomal lumen pH elevation") |
| pubmed:26968346 | p(HGNC:PSEN1, var("p.Ala246Glu")) decreases act(p(HGNC:CTSD)) |
| pubmed:29758300 | p(HGNC:PSEN1, var("p.Ala246Glu")) decreases bp(GO:autophagy) |
| pubmed:29758300 | p(HGNC:PSEN1, var("p.Ala246Glu")) decreases bp(GO:mitophagy) |
| pubmed:29758300 | p(HGNC:PSEN1, var("p.Ala246Glu")) decreases act(a(GO:lysosome)) |
| pubmed:26968346 | bp(GO:"lysosomal lumen pH elevation") increases p(HGNC:TFEB) |
| pubmed:22692785 | p(CONSO:PrPSc) negativeCorrelation p(HGNC:MARK4) |
| pubmed:26968346 | a(CHEBI:quinacrine) decreases path(DOID:malaria) |
| pubmed:26968346 | a(CHEBI:quinacrine) increases bp(GO:"autophagosome-lysosome fusion") |
| pubmed:26968346 | a(CHEBI:quinacrine) decreases path(DOID:"prion disease") |
| pubmed:30108137 | path(DOID:"lysosomal storage disease") association p(HGNC:TFEB, loc(GO:nucleus)) |
| pubmed:27299292 | path(DOID:"lysosomal storage disease") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) |
| pubmed:27299292 | path(DOID:"lysosomal storage disease") increases p(HGNC:TFEB, loc(GO:nucleus)) |
| pubmed:30108137 | a(CONSO:"Braak_Stage VI") positiveCorrelation r(HGNC:TFEB) |
| pubmed:26702100 | p(HGNC:LAMP1) association a(GO:lysosome) |
| pubmed:26702100 | p(HGNC:LAMP1) association a(GO:lysosome) |
| pubmed:30108137 | composite(a(MESH:Astrocytes), p(HGNC:TFEB)) increases p(CONSO:"Tau fibrils", loc(MESH:Astrocytes)) |
| pubmed:30108137 | composite(a(MESH:Astrocytes), p(HGNC:TFEB)) increases composite(a(PUBCHEM:102513886), p(MESH:"Serum Albumin, Bovine")) |
| pubmed:30108137 | composite(a(CHEBI:"torin 1"), a(MESH:Astrocytes), p(HGNC:TFEB)) increases p(CONSO:"Tau fibrils", loc(MESH:Astrocytes)) |
| pubmed:30108137 | composite(a(PUBCHEM:102513886), p(MESH:"Serum Albumin, Bovine")) increases deg(a(PUBCHEM:102513886)) |
| pubmed:30108137 | composite(a(PUBCHEM:102513886), p(MESH:"Serum Albumin, Bovine")) increases deg(p(MESH:"Serum Albumin, Bovine")) |
| pubmed:30108137 | a(CHEBI:heparin) decreases p(CONSO:"Tau fibrils", loc(MESH:Lysosomes)) |
| pubmed:29590627 | a(CHEBI:heparin) causesNoChange tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:29590627 | a(CHEBI:heparin) causesNoChange tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:25887395 | a(CHEBI:heparin) decreases a(CONSO:"Tau aggregates") |
| pubmed:29988016 | a(CHEBI:heparin) negativeCorrelation a(CONSO:"Tau aggregates") |
| pubmed:30108137 | a(CHEBI:heparin) decreases tloc(a(CONSO:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:25887395 | a(CHEBI:heparin) decreases complex(a(CONSO:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) |
| pubmed:29988016 | a(CHEBI:heparin) increases act(p(HGNC:MAPT, var("?"))) |
| pubmed:29686391 | a(CHEBI:heparin) negativeCorrelation tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | a(CHEBI:heparin) decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:26751493 | a(CHEBI:heparin) association p(CONSO:"Tau aggregates") |
| pubmed:27601475 | a(CHEBI:heparin) increases p(CONSO:"Tau aggregates") |
| pubmed:26751493 | a(CHEBI:heparin) partOf complex(a(CHEBI:heparin), p(CONSO:"Tau aggregates")) |
| pubmed:30108137 | bp(GO:macropinocytosis) increases tloc(p(CONSO:"Tau fibrils"), fromLoc(GO:cytoplasm), toLoc(MESH:Lysosomes)) |
| pubmed:29590627 | bp(GO:macropinocytosis) negativeCorrelation a(CHEBI:"cytochalasin D") |
| pubmed:29590627 | bp(GO:macropinocytosis) positiveCorrelation bp(GO:"actin filament polymerization") |
| pubmed:30108137 | bp(GO:macropinocytosis) increases act(a(MESH:Astrocytes)) |
| pubmed:30108137 | bp(GO:macropinocytosis) increases tloc(a(CONSO:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:26751493 | bp(GO:macropinocytosis) positiveCorrelation complex(a(CHEBI:heparin), p(CONSO:"Tau aggregates")) |
| pubmed:26751493 | bp(GO:macropinocytosis) association complex(a(CHEBI:heparin), p(CONSO:"Tau aggregates")) |
| pubmed:26751493 | bp(GO:macropinocytosis) isA tloc(a(CONSO:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) |
| pubmed:30108137 | complex(MESH:Dependovirus) increases p(HGNC:TFEB, loc(MESH:Astrocytes)) |
| pubmed:30108137 | complex(MESH:Dependovirus) increases act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:30108137 | complex(MESH:Dependovirus) increases p(HGNC:TFEB, loc(MESH:Astrocytes)) |
| pubmed:30108137 | complex(MESH:Dependovirus) increases r(HGNC:TFEB) |
| pubmed:30108137 | path(CONSO:"Pathological Tau Spreading") association tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30108137 | bp(GO:"ATP export") association bp(GO:"neuron-neuron synaptic transmission") |
| pubmed:30108137 | bp(GO:"reactive gliosis") increases p(HGNC:AIF1) |
| pubmed:30108137 | bp(GO:"reactive gliosis") increases p(HGNC:GFAP) |
| pubmed:27299292 | p(MESH:"AMP-Activated Protein Kinases") association p(HGNC:PPARGC1A) |
| pubmed:27299292 | complex(MESH:"Mechanistic Target of Rapamycin Complex 1") association p(HGNC:PPARGC1A) |
| pubmed:27299292 | complex(MESH:"Mechanistic Target of Rapamycin Complex 2") association p(HGNC:PPARGC1A) |
| pubmed:27299292 | bp(GO:"cellular response to starvation") increases act(p(HGNC:TFEB)) |
| pubmed:27299292 | bp(GO:"cellular response to starvation") increases act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:27299292 | bp(GO:"cellular response to starvation") decreases p(HGNC:TFEB, loc(GO:cytoplasm)) |
| pubmed:27299292 | bp(GO:"cellular response to starvation") increases act(p(HGNC:TFEB)) |
| pubmed:27299292 | bp(GO:"cellular response to starvation") increases act(p(HGNC:TFEB)) |
| pubmed:27299292 | bp(GO:"cellular response to starvation") increases p(HGNC:CREBBP) |
| pubmed:27299292 | bp(GO:"cellular response to starvation") decreases act(p(HGNC:MAPK1), ma(go:0016301 ! "kinase activity")) |
| pubmed:27299292 | bp(GO:"cellular response to starvation") decreases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 142)) |
| pubmed:27299292 | bp(GO:"cellular response to starvation") increases act(a(MESH:Lysosomes)) |
| pubmed:27299292 | bp(GO:"cellular response to starvation") decreases p(HGNCGENEFAMILY:"MTOR complex 1") |
| pubmed:27299292 | bp(GO:"cellular response to starvation") increases tloc(p(HGNC:MITF), fromLoc(MESH:Lysosomes), toLoc(GO:nucleus)) |
| pubmed:27299292 | bp(GO:"cellular response to starvation") increases tloc(p(HGNC:TFE3), fromLoc(MESH:Lysosomes), toLoc(GO:nucleus)) |
| pubmed:27299292 | composite(p(HGNC:MITF), p(HGNC:TFE3), p(HGNC:TFEB)) regulates bp(GO:mitophagy) |
| pubmed:27299292 | composite(p(HGNC:MITF), p(HGNC:TFE3), p(HGNC:TFEB)) association p(HGNC:PINK1) |
| pubmed:27299292 | composite(p(HGNC:MITF), p(HGNC:TFE3), p(HGNC:TFEB)) association p(HGNC:PRKN) |
| pubmed:27299292 | composite(p(HGNC:MITF), p(HGNC:TFE3), p(HGNC:TFEB)) association p(HGNC:ATG9A) |
| pubmed:27299292 | composite(p(HGNC:MITF), p(HGNC:TFE3), p(HGNC:TFEB)) association p(HGNC:ATG5) |
| pubmed:27299292 | act(p(HGNC:MITF)) increases a(GO:endolysosome) |
| pubmed:27299292 | act(p(HGNC:TFE3), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates a(MESH:Lysosomes) |
| pubmed:27299292 | act(p(HGNC:TFE3), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates bp(GO:autophagy) |
| pubmed:27299292 | act(p(HGNC:TFE3), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases p(HGNC:FLCN) |
| pubmed:27299292 | act(p(HGNC:TFE3), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases p(HGNC:FNIP1) |
| pubmed:27299292 | act(p(HGNC:TFE3), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases p(HGNC:FNIP2) |
| pubmed:27299292 | act(p(HGNC:TFE3), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) decreases bp(GO:"cellular response to starvation") |
| pubmed:27299292 | p(HGNC:TFE3) regulates bp(GO:"cellular response to stress") |
| pubmed:27299292 | p(HGNC:TFE3) regulates p(HGNC:PPARGC1A) |
| pubmed:27299292 | p(HGNC:TFE3) association p(HGNC:ATF4) |
| pubmed:27299292 | p(HGNC:TFE3) increases bp(GO:"calcium ion regulated lysosome exocytosis") |
| pubmed:27299292 | act(p(HGNC:TFE3)) directlyIncreases bp(GO:"catabolic process") |
| pubmed:27299292 | p(HGNC:ATG9A) association composite(p(HGNC:MITF), p(HGNC:TFE3), p(HGNC:TFEB)) |
| pubmed:27299292 | composite(p(HGNC:ATG5), p(HGNC:ATG9A), p(HGNC:MITF), p(HGNC:PINK1), p(HGNC:PRKN), p(HGNC:TFE3), p(HGNC:TFEB)) positiveCorrelation bp(GO:mitophagy) |
| pubmed:27299292 | p(HGNC:ZKSCAN3) decreases bp(GO:autophagy) |
| pubmed:27299292 | p(HGNC:ZKSCAN3) decreases act(p(HGNC:TFEB)) |
| pubmed:30116051 | p(HGNC:ZKSCAN3) decreases bp(GO:macroautophagy) |
| pubmed:27299292 | bp(GO:"lipid catabolic process") positiveCorrelation p(HGNC:TFEB) |
| pubmed:27299292 | bp(MESH:"Diet, High-Fat") regulates bp(GO:"lipid catabolic process") |
| pubmed:27299292 | p(HGNC:GBA, var("p.Leu444Pro")) positiveCorrelation path(DOID:"Gaucher's disease") |
| pubmed:27299292 | p(HGNC:GBA, var("p.Leu444Pro")) negativeCorrelation bp(GO:"protein transport") |
| pubmed:27299292 | p(HGNC:GBA, var("p.Leu444Pro")) negativeCorrelation bp(GO:"protein maturation") |
| pubmed:27299292 | bp(GO:"protein maturation") negativeCorrelation p(HGNC:GBA, var("p.Leu444Pro")) |
| pubmed:27299292 | bp(GO:"protein maturation") positiveCorrelation p(HGNC:TFEB) |
| pubmed:27299292 | complex(m(MIRBASE:hsa-mir-128-1), r(HGNC:TFEB)) decreases p(HGNC:TFEB) |
| pubmed:27299292 | complex(m(MIRBASE:hsa-mir-128-2), r(HGNC:TFEB)) decreases p(HGNC:TFEB) |
| pubmed:27299292 | a(CHEBI:sucrose) increases bp(MESH:"Stress, Physiological") |
| pubmed:27299292 | a(CHEBI:"arsenic(3+)") increases bp(MESH:"Stress, Physiological") |
| pubmed:27299292 | a(CHEBI:"arsenic(3+)") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) |
| pubmed:27299292 | bp(GO:"response to transition metal nanoparticle") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) |
| pubmed:27299292 | bp(GO:"cellular response to ethanol") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) |
| pubmed:27299292 | bp(GO:"response to doxorubicin") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) |
| pubmed:27299292 | bp(GO:"response to doxorubicin") positiveCorrelation bp(GO:"cellular senescence") |
| pubmed:27299292 | bp(GO:"cellular senescence") positiveCorrelation bp(GO:"response to doxorubicin") |
| pubmed:30126037 | bp(GO:"cellular senescence") association bp(GO:"cell cycle") |
| pubmed:30126037 | bp(GO:"cellular senescence") increases bp(MESH:"Cell Survival") |
| pubmed:30126037 | bp(GO:"cellular senescence") increases bp(MESH:"Cell Survival") |
| pubmed:30126037 | bp(GO:"cellular senescence") association bp(MESH:"Cell Survival") |
| pubmed:30126037 | bp(GO:"cellular senescence") increases bp(GO:"tissue remodeling") |
| pubmed:30126037 | bp(GO:"cellular senescence") increases bp(GO:"tissue remodeling") |
| pubmed:30126037 | bp(GO:"cellular senescence") decreases bp(GO:"metabolic process") |
| pubmed:30126037 | bp(GO:"cellular senescence") decreases bp(GO:"metabolic process") |
| pubmed:30126037 | bp(GO:"cellular senescence") association p(MGI:Cdkn2a) |
| pubmed:30126037 | bp(GO:"cellular senescence") increases a(GO:"neurofibrillary tangle") |
| pubmed:30126037 | bp(GO:"cellular senescence") association a(GO:"neurofibrillary tangle") |
| pubmed:30126037 | bp(GO:"cellular senescence") increases bp(GO:"neuron death") |
| pubmed:30126037 | bp(GO:"cellular senescence") increases path(MESH:"Hypertrophy, Right Ventricular") |
| pubmed:30126037 | bp(GO:"cellular senescence") increases path(MESH:"Hypertrophy, Left Ventricular") |
| pubmed:30126037 | bp(GO:"cellular senescence") increases bp(HP:Neurodegeneration) |
| pubmed:30126037 | bp(GO:"cellular senescence") association path(MESH:Tauopathies) |
| pubmed:30126037 | bp(GO:"cellular senescence") increases bp(GO:"cell cycle arrest") |
| pubmed:30126037 | bp(GO:"cellular senescence") decreases tloc(a(MESH:Immunotoxins), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30126037 | bp(GO:"cellular senescence") increases bp(MESH:"DNA Damage") |
| pubmed:30126037 | bp(GO:"cellular senescence") association bp(MESH:"DNA Damage") |
| pubmed:30126037 | bp(GO:"cellular senescence") increases p(MGI:Cdkn1a) |
| pubmed:30126037 | bp(GO:"cellular senescence") increases p(HGNC:CDKN2A) |
| pubmed:30126037 | bp(GO:"cellular senescence") association bp(GO:"inflammatory response") |
| pubmed:30126037 | bp(GO:"cellular senescence") increases path(CONSO:CONSO00037) |
| pubmed:29221819 | bp(GO:"cellular senescence") positiveCorrelation p(MGI:Dyrk1a) |
| pubmed:27299292 | complex(p(HGNC:PPARGC1A), r(HGNC:TFEB)) regulates p(HGNC:TFEB) |
| pubmed:27299292 | complex(p(HGNC:PPARGC1A), r(HGNC:TFEB)) regulates act(p(HGNC:TFEB)) |
| pubmed:27299292 | complex(p(HGNC:PPARGC1A), r(HGNC:TFEB)) regulates bp(GO:mitophagy) |
| pubmed:27299292 | complex(p(HGNC:PPARGC1A), p(HGNC:RXRA), r(HGNC:TFEB)) regulates act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:27299292 | a(CHEBI:gemfibrozil) increases act(p(HGNC:PPARGC1A)) |
| pubmed:27299292 | bp(GO:"cellular response to nutrient") increases p(HGNC:NR1H4) |
| pubmed:27299292 | bp(GO:"cellular response to nutrient") increases complex(p(HGNC:MITF), p(HGNC:YWHAQ)) |
| pubmed:27299292 | bp(GO:"cellular response to nutrient") increases complex(p(HGNC:TFE3), p(HGNC:YWHAQ)) |
| pubmed:27299292 | bp(GO:"cellular response to nutrient") increases act(p(HGNC:TFE3), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:27299292 | p(HGNC:NR1H4) increases p(HGNC:TFEB) |
| pubmed:27299292 | p(HGNC:NR1H4) regulates act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:27299292 | bp(GO:"biosynthetic process") association act(p(HGNCGENEFAMILY:"MTOR complex 1"), ma(go:0016301 ! "kinase activity")) |
| pubmed:27299292 | bp(GO:"catabolic process") association act(p(HGNCGENEFAMILY:"MTOR complex 1"), ma(go:0016301 ! "kinase activity")) |
| pubmed:27299292 | p(HGNC:TSC2) positiveCorrelation p(HGNCGENEFAMILY:"MTOR complex 1") |
| pubmed:27299292 | p(HGNC:TSC2) increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27299292 | p(HGNC:TSC2) decreases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) |
| pubmed:27299292 | composite(a(CHEBI:sirolimus), p(HGNC:TFEB, frag("?_*"))) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) |
| pubmed:27299292 | composite(p(HGNC:TFEB), p(HGNC:YWHAQ)) increases p(HGNC:TFEB, loc(GO:cytosol)) |
| pubmed:27299292 | composite(p(HGNC:TFEB), p(HGNC:YWHAQ)) decreases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) |
| pubmed:27299292 | composite(p(HGNC:TFEB), p(HGNC:YWHAQ)) decreases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) |
| pubmed:27299292 | p(HGNC:TFEB, frag("241_252")) isA a(MESH:"Nuclear Localization Signals") |
| pubmed:27299292 | bp(GO:"response to nutrient levels") causesNoChange act(complex(GO:"Ragulator complex")) |
| pubmed:27299292 | p(HGNC:TFEB, frag("1_30")) increases p(HGNC:TFEB, loc(MESH:Lysosomes)) |
| pubmed:27299292 | bp(GO:"amino acid activation") increases composite(complex(GO:"Ragulator complex"), p(HGNC:TFEB)) |
| pubmed:27299292 | composite(complex(GO:"Ragulator complex"), p(HGNC:TFEB)) increases p(HGNC:TFEB, loc(MESH:Lysosomes)) |
| pubmed:27299292 | a(PUBCHEM:17755052) decreases act(p(HGNC:PIK3CA)) |
| pubmed:27299292 | a(PUBCHEM:17755052) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) |
| pubmed:27299292 | p(HGNC:TNFSF11) increases act(p(HGNC:PRKCB)) |
| pubmed:27299292 | p(HGNC:TNFSF11) regulates bp(GO:"osteoclast differentiation") |
| pubmed:27299292 | act(p(HGNC:PRKCB)) increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser)) |
| pubmed:27299292 | p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser)) increases act(p(HGNC:TFEB)) |
| pubmed:27299292 | bp(GO:"response to chloroquine") increases bp(MESH:"Stress, Physiological") |
| pubmed:27299292 | bp(GO:"response to chloroquine") increases tloc(p(HGNC:MITF), fromLoc(MESH:Lysosomes), toLoc(GO:nucleus)) |
| pubmed:27299292 | bp(GO:"response to chloroquine") increases tloc(p(HGNC:TFE3), fromLoc(MESH:Lysosomes), toLoc(GO:nucleus)) |
| pubmed:27299292 | p(HGNC:FLCN) positiveCorrelation act(p(HGNCGENEFAMILY:"MTOR complex 1")) |
| pubmed:27299292 | p(HGNC:FLCN) association tloc(p(HGNCGENEFAMILY:"MTOR complex 1"), fromLoc(GO:cytoplasm), toLoc(GO:"lysosomal membrane")) |
| pubmed:27299292 | p(HGNC:FLCN) association act(p(HGNCGENEFAMILY:"MTOR complex 1")) |
| pubmed:27299292 | p(HGNC:FLCN) negativeCorrelation path(DOID:"Birt-Hogg-Dube syndrome") |
| pubmed:27299292 | complex(p(HGNC:SNCA), p(HGNC:TFEB)) increases p(HGNC:TFEB, loc(GO:cytoplasm)) |
| pubmed:27299292 | complex(p(HGNC:SNCA), p(HGNC:TFEB)) decreases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:27299292 | p(HGNC:AR, pmod(CONSO:"CAG repeats")) positiveCorrelation bp(GO:autophagy) |
| pubmed:27299292 | p(HGNC:AR, pmod(CONSO:"CAG repeats")) negativeCorrelation bp(GO:autophagy) |
| pubmed:27299292 | p(HGNC:AR, pmod(CONSO:"CAG repeats")) negativeCorrelation bp(GO:autophagy) |
| pubmed:27299292 | p(HGNC:AR, pmod(CONSO:"CAG repeats")) increases p(HGNC:NFYA) |
| pubmed:27299292 | p(HGNC:AR, pmod(CONSO:"CAG repeats")) decreases act(a(MESH:Lysosomes)) |
| pubmed:27299292 | p(HGNC:AR, pmod(CONSO:"CAG repeats")) decreases act(p(HGNC:TFEB)) |
| pubmed:27299292 | p(HGNC:AR) increases r(HGNC:TFEB) |
| pubmed:30640040 | p(HGNC:AR) association a(PUBCHEM:5833) |
| pubmed:27299292 | path(DOID:"spinal muscular atrophy") negativeCorrelation act(p(HGNCGENEFAMILY:"MTOR complex 1")) |
| pubmed:27299292 | path(DOID:"spinal muscular atrophy") negativeCorrelation bp(GO:autophagy) |
| pubmed:27299292 | path(DOID:"spinal muscular atrophy") positiveCorrelation path(CONSO:"mitochondrial dysfunction") |
| pubmed:27299292 | p(HGNC:NFYA) decreases p(HGNC:TFEB) |
| pubmed:27299292 | p(HGNC:NFYA) increases bp(GO:"nuclear protein quality control by the ubiquitin-proteasome system") |
| pubmed:27299292 | composite(p(HGNC:NFYA), p(HGNC:TFEB)) decreases act(a(MESH:Lysosomes)) |
| pubmed:27299292 | composite(p(HGNC:NFYA), p(HGNC:TFEB)) decreases bp(GO:autophagy) |
| pubmed:27299292 | composite(p(HGNC:NFYA), p(HGNC:TFEB)) increases p(HGNC:AR, pmod(CONSO:"CAG repeats")) |
| pubmed:27299292 | p(HGNC:SESN2) association p(HGNCGENEFAMILY:"MTOR complex 1") |
| pubmed:30116051 | p(HGNC:SESN2) increases act(p(FPLX:AMPK)) |
| pubmed:30116051 | p(HGNC:SESN2) increases bp(GO:macroautophagy) |
| pubmed:30116051 | p(HGNC:SESN2) increases bp(GO:macroautophagy) |
| pubmed:30116051 | p(HGNC:SESN2) increases act(p(FPLX:mTORC1)) |
| pubmed:27299292 | path(CONSO:"protein aggregation") negativeCorrelation act(a(MESH:Lysosomes)) |
| pubmed:27299292 | path(CONSO:"protein aggregation") decreases p(HGNC:TFEB) |
| pubmed:27299292 | path(CONSO:"protein aggregation") decreases act(p(HGNC:TFEB)) |
| pubmed:27299292 | path(DOID:"Birt-Hogg-Dube syndrome") negativeCorrelation p(HGNC:FLCN) |
| pubmed:27299292 | path(DOID:"Birt-Hogg-Dube syndrome") positiveCorrelation path(DOID:"hair follicle neoplasm") |
| pubmed:27299292 | path(DOID:"Birt-Hogg-Dube syndrome") increases path(MESH:Cysts) |
| pubmed:27299292 | path(DOID:"Birt-Hogg-Dube syndrome") positiveCorrelation path(DOID:"renal carcinoma") |
| pubmed:27299292 | path(DOID:"hair follicle neoplasm") positiveCorrelation path(DOID:"Birt-Hogg-Dube syndrome") |
| pubmed:27299292 | composite(p(HGNC:FLCN), p(HGNCGENEFAMILY:"MTOR complex 1")) increases p(HGNC:TFEB) |
| pubmed:27299292 | composite(p(HGNC:FLCN), p(HGNCGENEFAMILY:"MTOR complex 1")) increases act(p(HGNC:TFEB)) |
| pubmed:27299292 | composite(p(HGNC:FLCN), p(HGNCGENEFAMILY:"MTOR complex 1")) increases a(MESH:Lysosomes) |
| pubmed:27299292 | path(DOID:"pancreatic ductal adenocarcinoma") increases p(HGNC:IPO8) |
| pubmed:27299292 | complex(p(HGNC:IPO8), p(HGNC:TFE3)) negativeCorrelation p(HGNCGENEFAMILY:"MTOR complex 1") |
| pubmed:27299292 | complex(p(HGNC:IPO8), p(HGNC:TFE3)) increases tloc(p(HGNC:TFE3), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:27299292 | complex(p(HGNC:IPO8), p(HGNC:TFEB)) negativeCorrelation p(HGNCGENEFAMILY:"MTOR complex 1") |
| pubmed:27299292 | complex(p(HGNC:IPO8), p(HGNC:TFEB)) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:27299292 | complex(p(HGNC:IPO8), p(HGNC:MITF)) negativeCorrelation p(HGNCGENEFAMILY:"MTOR complex 1") |
| pubmed:27299292 | complex(p(HGNC:IPO8), p(HGNC:MITF)) increases tloc(p(HGNC:MITF), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:27299292 | complex(p(INTERPRO:"MiT/TFE transcription factors, C-terminal"), p(INTERPRO:"MiT/TFE transcription factors, N-terminal")) increases act(a(MESH:Lysosomes)) |
| pubmed:27299292 | complex(p(INTERPRO:"MiT/TFE transcription factors, C-terminal"), p(INTERPRO:"MiT/TFE transcription factors, N-terminal")) increases bp(GO:autophagy) |
| pubmed:27299292 | a(CHEBI:"angiotensin II") increases complex(GO:"Fused-Smurf ubiquitin ligase complex") |
| pubmed:27299292 | complex(GO:"Fused-Smurf ubiquitin ligase complex") increases p(HGNC:TRIM63) |
| pubmed:27299292 | p(HGNC:TRIM63) directlyIncreases act(p(HGNC:TFEB)) |
| pubmed:27299292 | a(CHEBI:glycogen, loc(MESH:Muscles)) increases path(DOID:"glycogen storage disease II") |
| pubmed:27299292 | a(CHEBI:paeoniflorin) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:27299292 | a(CHEBI:paeoniflorin) increases act(p(HGNC:TFEB)) |
| pubmed:27299292 | bp(GO:"nuclear protein quality control by the ubiquitin-proteasome system") increases deg(p(HGNC:AR, pmod(CONSO:"CAG repeats"))) |
| pubmed:27299292 | bp(GO:"nuclear protein quality control by the ubiquitin-proteasome system") decreases path(DOID:"spinal muscular atrophy") |
| pubmed:27299292 | p(HGNC:SERPINA1, pmod(CONSO:misfolded)) increases p(HGNC:SERPINA1, pmod(CONSO:"protein aggregates")) |
| pubmed:25437566 | act(p(FPLX:HSPA)) association a(CHEBI:ATP) |
| pubmed:27491084 | p(FPLX:HSPA) association bp(CONSO:Proteostasis) |
| pubmed:27491084 | p(FPLX:HSPA) decreases p(CONSO:"huntingtin aggregates") |
| pubmed:27491084 | p(FPLX:HSPA) decreases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:24563850 | p(FPLX:HSPA) decreases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:27491084 | p(FPLX:HSPA) increases bp(GO:"'de novo' protein folding") |
| pubmed:23746257 | act(p(FPLX:HSPA)) association bp(GO:"'de novo' protein folding") |
| pubmed:23746257 | act(p(FPLX:HSPA)) association bp(GO:"'de novo' protein folding") |
| pubmed:24563850 | p(FPLX:HSPA) increases bp(GO:"'de novo' protein folding") |
| pubmed:27491084 | p(FPLX:HSPA) decreases bp(CONSO:misfolding) |
| pubmed:27491084 | p(FPLX:HSPA) association bp(CONSO:misfolding) |
| pubmed:24563850 | p(FPLX:HSPA) decreases bp(CONSO:misfolding) |
| pubmed:27491084 | p(FPLX:HSPA) decreases a(MESH:"Protein Aggregates") |
| pubmed:27491084 | p(FPLX:HSPA) decreases a(MESH:"Protein Aggregates") |
| pubmed:27491084 | p(FPLX:HSPA) decreases path(CONSO:proteotoxicity) |
| pubmed:27491084 | p(FPLX:HSPA) decreases path(CONSO:proteotoxicity) |
| pubmed:27491084 | p(FPLX:HSPA) decreases a(CONSO:"alpha-synuclein aggregates") |
| pubmed:23746257 | p(FPLX:HSPA) decreases a(CONSO:"alpha-synuclein aggregates") |
| pubmed:14556719 | p(FPLX:HSPA) increases complex(p(HGNC:ATXN3, frag("?")), p(HGNC:PRKN)) |
| pubmed:14556719 | p(FPLX:HSPA) decreases a(CONSO:"protein aggregates") |
| pubmed:14556719 | p(FPLX:HSPA) decreases bp(GO:"cell death") |
| pubmed:23746257 | act(p(FPLX:HSPA)) association bp(GO:"protein refolding") |
| pubmed:23746257 | act(p(FPLX:HSPA)) association bp(GO:"protein refolding") |
| pubmed:23746257 | act(p(FPLX:HSPA)) association bp(GO:"intracellular protein transmembrane transport") |
| pubmed:23746257 | act(p(FPLX:HSPA)) association bp(GO:"protein catabolic process") |
| pubmed:23746257 | p(FPLX:HSPA) decreases a(CONSO:"huntingtin aggregates") |
| pubmed:25784053 | p(FPLX:HSPA) isA a(MESH:"Molecular Chaperones") |
| pubmed:25784053 | p(FPLX:HSPA) regulates bp(GO:"protein folding") |
| pubmed:24563850 | p(FPLX:HSPA) increases bp(GO:"protein folding") |
| pubmed:25784053 | p(FPLX:HSPA) regulates bp(MESH:Proteolysis) |
| pubmed:25784053 | p(FPLX:HSPA) positiveCorrelation path(MESH:"Huntington Disease") |
| pubmed:29626319 | p(FPLX:HSPA) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:25437566 | act(p(HGNC:HSPD1)) association a(CHEBI:ATP) |
| pubmed:27491084 | p(HGNC:HSPD1) association bp(CONSO:Proteostasis) |
| pubmed:25784053 | p(HGNC:HSPD1) increases bp(CONSO:Proteostasis) |
| pubmed:23746257 | p(HGNC:HSPD1) decreases a(MESH:"Protein Aggregates") |
| pubmed:25784053 | p(HGNC:HSPD1) isA a(MESH:"Molecular Chaperones") |
| pubmed:25784053 | p(HGNC:HSPD1) association bp(MESH:"Energy Metabolism") |
| pubmed:25437566 | act(p(HGNCGENEFAMILY:"AAA ATPases")) association a(CHEBI:ATP) |
| pubmed:27491084 | p(HGNCGENEFAMILY:"AAA ATPases") association bp(CONSO:Proteostasis) |
| pubmed:27491084 | p(HGNC:TPR) association bp(CONSO:Proteostasis) |
| pubmed:27491084 | p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") association bp(CONSO:Proteostasis) |
| pubmed:27491084 | p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") increases act(p(FPLX:HSPA), ma(GO:"ATPase activity")) |
| pubmed:23746257 | p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") regulates act(p(FPLX:HSPA)) |
| pubmed:23746257 | p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") decreases a(CONSO:"huntingtin aggregates") |
| pubmed:23746257 | p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") decreases a(CONSO:"alpha-synuclein aggregates") |
| pubmed:25784053 | p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") isA a(MESH:"Molecular Chaperones") |
| pubmed:27491084 | p(FPLX:HSPB) association bp(CONSO:Proteostasis) |
| pubmed:27491084 | p(FPLX:HSPB) association bp(CONSO:misfolding) |
| pubmed:23746257 | act(p(FPLX:HSPB)) decreases a(MESH:"Protein Aggregates") |
| pubmed:25784053 | p(FPLX:HSPB) isA a(MESH:"Molecular Chaperones") |
| pubmed:30837838 | p(HGNC:DNAJB2) increases complex(p(CONSO:"TDP-43 aggregates"), p(HGNCGENEFAMILY:"Heat shock 70kDa proteins")) |
| pubmed:25437566 | p(FPLX:"CCT_complex") decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:25437566 | p(FPLX:"CCT_complex") increases a(CONSO:"huntingtin aggregates") |
| pubmed:23746257 | p(FPLX:"CCT_complex") decreases a(CONSO:"huntingtin aggregates") |
| pubmed:25784053 | p(FPLX:"CCT_complex") association a(MESH:"Cellular Structures") |
| pubmed:25784053 | p(FPLX:"CCT_complex") association bp(GO:"cell division") |
| pubmed:25784053 | p(FPLX:"CCT_complex") association bp(GO:"intracellular transport") |
| pubmed:25784053 | p(FPLX:"CCT_complex") decreases act(p(HGNC:HSF1)) |
| pubmed:25437566 | p(HGNC:DNAJA1) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:25437566 | p(HGNC:DNAJA1) increases bp(GO:"protein folding") |
| pubmed:25437566 | p(HGNC:DNAJA1) increases a(CONSO:"huntingtin aggregates") |
| pubmed:25437566 | p(HGNC:CDC37) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:23746257 | p(HGNC:CDC37) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pubmed:21882945 | p(HGNC:CDC37) regulates act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pubmed:21367866 | p(HGNC:CDC37) positiveCorrelation act(p(FPLX:HSP90)) |
| pubmed:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pubmed:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:AHSA1), p(HGNC:CDC37)) |
| pubmed:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:AURKB), p(HGNC:CDC37)) |
| pubmed:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CDK11A)) |
| pubmed:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CDK1)) |
| pubmed:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:IKBKG)) |
| pubmed:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CDK4)) |
| pubmed:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:FER)) |
| pubmed:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:IKBKB)) |
| pubmed:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CHUK)) |
| pubmed:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:RAF1)) |
| pubmed:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:ABL2), p(HGNC:CDC37)) |
| pubmed:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:ARAF), p(HGNC:CDC37)) |
| pubmed:25036637 | p(HGNC:CDC37) association p(HGNC:FKBP5) |
| pubmed:25036637 | p(HGNC:CDC37) directlyIncreases complex(a(MESH:"Protein Kinases"), p(HGNC:CDC37)) |
| pubmed:21882945 | p(HGNC:CDC37) increases complex(a(MESH:"Protein Kinases"), p(FPLX:HSP90)) |
| pubmed:21367866 | p(HGNC:CDC37) isA complex(p(FPLX:HSP90), p(HGNC:CDC37)) |
| pubmed:29311797 | p(HGNC:CDC37) increases p(HGNC:MAPT) |
| pubmed:21367866 | p(HGNC:CDC37) decreases deg(p(HGNC:MAPT)) |
| pubmed:21367866 | p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:21367866 | p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:21367866 | p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:21367866 | p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:21367866 | p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:21367866 | p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:21367866 | p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) |
| pubmed:21367866 | p(HGNC:CDC37) negativeCorrelation act(p(HGNC:CDK5), ma(go:0016301 ! "kinase activity")) |
| pubmed:21367866 | p(HGNC:CDC37) negativeCorrelation act(p(HGNC:AKT1), ma(go:0016301 ! "kinase activity")) |
| pubmed:21367866 | p(HGNC:CDC37) causesNoChange p(HGNC:GSK3B) |
| pubmed:21367866 | p(HGNC:CDC37) causesNoChange p(HGNC:MARK2) |
| pubmed:25437566 | p(HGNC:STIP1) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:23746257 | p(HGNC:STIP1) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pubmed:25036637 | p(HGNC:STIP1) increases complex(p(HGNC:STIP1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pubmed:29311797 | p(HGNC:STIP1) decreases p(HGNC:MAPT) |
| pubmed:29311797 | p(HGNC:STIP1) association bp(GO:"chaperone-mediated autophagy") |
| pubmed:25437566 | p(HGNC:TTC1) increases bp(GO:"protein folding") |
| pubmed:25437566 | p(HGNC:CCT5) causesNoChange a(CONSO:"huntingtin aggregates") |
| pubmed:25437566 | p(HGNC:DNAJA4) increases a(CONSO:"huntingtin aggregates") |
| pubmed:25437566 | p(HGNC:HSPA14) increases a(CONSO:"huntingtin aggregates") |
| pubmed:25437566 | p(HGNC:CDC23) increases a(CONSO:"huntingtin aggregates") |
| pubmed:25437566 | p(HGNC:CDC27) increases a(CONSO:"huntingtin aggregates") |
| pubmed:25036637 | p(HGNC:HSP90AB1) directlyIncreases complex(a(MESH:"Protein Kinases"), p(HGNC:HSP90AB1)) |
| pubmed:29311797 | p(HGNC:HSP90AB1) association bp(GO:"embryo development") |
| pubmed:29311797 | p(HGNC:HSP90AB1) association bp(GO:"cell maturation") |
| pubmed:29311797 | p(HGNC:HSP90AB1) association bp(GO:"cytoskeleton organization") |
| pubmed:29311797 | p(HGNC:HSP90AB1) association bp(GO:"signal transduction") |
| pubmed:29311797 | p(HGNC:HSP90AB1) association bp(GO:"adaptation of signaling pathway") |
| pubmed:27491084 | p(HGNC:HSPA1L) decreases path(HP:Neurodegeneration) |
| pubmed:27491084 | p(HGNC:HSPA1L) decreases path(HP:Neurodegeneration) |
| pubmed:27491084 | p(HGNC:ATXN3, var("?")) association path(HP:Neurodegeneration) |
| pubmed:23528736 | p(HGNC:ATXN3, var("?")) association path(MESH:"Neurodegenerative Diseases") |
| pubmed:27491084 | p(HGNC:AR, var("?")) association path(HP:Neurodegeneration) |
| pubmed:27491084 | p(UNIPROT:P15705) decreases path(CONSO:proteotoxicity) |
| pubmed:27491084 | p(UNIPROT:P32589) regulates act(p(FPLX:HSPA)) |
| pubmed:27491084 | p(UNIPROT:P32589) decreases path(CONSO:proteotoxicity) |
| pubmed:27491084 | p(UNIPROT:P32589) decreases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:27491084 | p(HGNC:HSPB7) decreases path(CONSO:proteotoxicity) |
| pubmed:27491084 | p(HGNC:HSPB7) decreases a(MESH:"Protein Aggregates") |
| pubmed:27491084 | p(UNIPROT:Q9XXG5) decreases path(CONSO:proteotoxicity) |
| pubmed:27491084 | p(UNIPROT:Q9XXG5) decreases a(MESH:"Protein Aggregates") |
| pubmed:27491084 | p(UNIPROT:P12612) decreases path(CONSO:proteotoxicity) |
| pubmed:27491084 | p(UNIPROT:P12612) decreases a(MESH:"Protein Aggregates") |
| pubmed:27491084 | p(UNIPROT:P02829) decreases path(CONSO:proteotoxicity) |
| pubmed:27491084 | p(UNIPROT:P02829) decreases a(MESH:"Protein Aggregates") |
| pubmed:23746257 | bp(GO:"'de novo' protein folding") association act(p(HGNCGENEFAMILY:Chaperonins)) |
| pubmed:23746257 | bp(GO:"'de novo' protein folding") association act(p(FPLX:HSPA)) |
| pubmed:23746257 | bp(GO:"'de novo' protein folding") association act(p(FPLX:HSPA)) |
| pubmed:23746257 | bp(GO:"'de novo' protein folding") association act(p(FPLX:HSP90)) |
| pubmed:27491084 | bp(CONSO:misfolding) association p(FPLX:HSPA) |
| pubmed:27491084 | bp(CONSO:misfolding) association p(FPLX:HSPB) |
| pubmed:24563850 | bp(CONSO:misfolding) increases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:27491084 | p(HGNC:CRYAB) association a(CONSO:"amyloid-beta aggregates") |
| pubmed:27491084 | p(HGNC:HSPB6) association a(CONSO:"amyloid-beta aggregates") |
| pubmed:27491084 | a(PUBCHEM:40009526) decreases complex(a(CHEBI:ATP), p(HGNC:HSPA1A)) |
| pubmed:27491084 | a(PUBCHEM:40009526) decreases complex(a(CHEBI:ATP), p(HGNC:HSPA1B)) |
| pubmed:25784053 | p(HGNC:HSPA1A) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pubmed:22817713 | p(HGNC:HSPA1A) decreases a(CONSO:"Tau aggregates") |
| pubmed:22817713 | p(HGNC:HSPA1A) increases deg(a(CONSO:"Tau aggregates")) |
| pubmed:25784053 | p(HGNC:HSPA1B) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30562574 | composite(a(MESH:"Molecular Chaperones"), a(MESH:Proteins)) increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) |
| pubmed:30562574 | composite(a(MESH:"Molecular Chaperones"), a(MESH:Proteins)) increases path(MESH:"Protein Unfolding") |
| pubmed:30562574 | a(MESH:Proteome) regulates bp(GO:"chaperone-mediated autophagy") |
| pubmed:30562574 | complex(p(HGNC:LAMP2), p(HGNC:PARK7)) decreases bp(GO:"cell death") |
| pubmed:30562574 | complex(p(HGNC:LAMP2), p(HGNC:PARK7)) decreases act(a(MESH:1-Methyl-4-phenylpyridinium)) |
| pubmed:22908190 | a(CONSO:"dystrophic neurite") association a(CONSO:"paired helical filaments") |
| pubmed:22908190 | a(CONSO:"dystrophic neurite") association a(MESH:Ubiquitin) |
| pubmed:22908190 | a(CONSO:"dystrophic neurite") association a(GO:autophagosome) |
| pubmed:22908190 | a(CONSO:"dystrophic neurite") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23531502 | a(CONSO:"dystrophic neurite") association act(a(CHEBI:acrolein)) |
| pubmed:28877763 | a(CONSO:"dystrophic neurite") association path(MESH:"Plaque, Amyloid") |
| pubmed:24401760 | a(CONSO:"dystrophic neurite") association path(MESH:"Plaque, Amyloid") |
| pubmed:24401760 | a(CONSO:"dystrophic neurite") positiveCorrelation p(HGNC:ITPKB) |
| pubmed:29758300 | a(GO:autolysosome) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:18930136 | a(GO:autolysosome) positiveCorrelation path(MESH:"Huntington Disease") |
| pubmed:18930136 | a(GO:autolysosome) decreases path(CONSO:Neurodegeneration) |
| pubmed:29758300 | p(HGNCGENEFAMILY:Cathepsins) increases bp(GO:"lysosomal protein catabolic process") |
| pubmed:22908190 | p(HGNCGENEFAMILY:Cathepsins) increases bp(GO:"lysosomal protein catabolic process") |
| pubmed:26702100 | p(HGNCGENEFAMILY:Cathepsins) association a(GO:lysosome) |
| pubmed:29758300 | p(HGNC:BECN1, frag("?")) association a(GO:"neurofibrillary tangle") |
| pubmed:30116051 | p(HGNC:BECN1, frag("?")) decreases act(p(HGNC:BECN1)) |
| pubmed:29758300 | bp(GO:"regulation of lysosomal lumen pH") association p(HGNC:PSEN1) |
| pubmed:26702100 | a(MESH:"Vacuolar Proton-Translocating ATPases") association a(GO:lysosome) |
| pubmed:29758300 | a(GO:organelle) increases bp(GO:"neuron cellular homeostasis") |
| pubmed:29758300 | a(GO:organelle) increases a(MESH:Neurons) |
| pubmed:14556719 | p(MESH:Proteins, pmod(CONSO:misfolding)) increases bp(GO:"response to unfolded protein") |
| pubmed:24457024 | p(MESH:Proteins, pmod(CONSO:misfolding)) increases bp(CONSO:"protein aggregation") |
| pubmed:18930136 | p(MESH:Proteins, pmod(CONSO:misfolding)) positiveCorrelation path(MESH:"Neurodegenerative Diseases") |
| pubmed:18930136 | p(MESH:Proteins, pmod(CONSO:misfolding)) increases p(HGNC:SQSTM1) |
| pubmed:18930136 | p(MESH:Proteins, pmod(CONSO:misfolding)) increases r(HGNC:SQSTM1) |
| pubmed:29758300 | p(MESH:"Amyloid beta-Peptides", pmod(CONSO:misfolding)) increases path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | act(complex(GO:"TOR complex")) positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:29626319 | complex(GO:"TOR complex") increases bp(GO:"lysosomal microautophagy") |
| pubmed:29758300 | path(MESH:"Niemann-Pick Diseases") association p(HGNC:MAPT) |
| pubmed:22908190 | path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(CONSO:"UBB+1") |
| pubmed:26751493 | path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(CONSO:"3R tau") |
| pubmed:26631930 | path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(CONSO:"3R tau") |
| pubmed:26751493 | path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HGNC:PSEN1, var("p.Gly183Val")) |
| pubmed:26631930 | path(MESH:"Niemann-Pick Diseases") isA path(MESH:Tauopathies) |
| pubmed:26631930 | path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:29758300 | p(FPLX:MAPK) regulates p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29191965 | p(FPLX:MAPK) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:8702879 | act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 62)) |
| pubmed:8702879 | act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 67)) |
| pubmed:8702879 | act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 551)) |
| pubmed:29758300 | composite(p(HGNC:HSPA8), p(HGNC:LAMP2)) increases tloc(p(HGNC:MAPT), fromLoc(GO:cytosol), toLoc(GO:lysosome)) |
| pubmed:29758300 | p(HGNC:NBR1) association p(HGNC:MAPT) |
| pubmed:27181519 | p(HGNC:NBR1) regulates bp(GO:macroautophagy) |
| pubmed:29758300 | p(HGNC:SNCA, pmod(CONSO:misfolding)) increases a(CONSO:"alpha-synuclein oligomers") |
| pubmed:29758300 | a(CONSO:"alpha-synuclein oligomers") increases path(CONSO:neuroinflammation) |
| pubmed:29758300 | a(CONSO:"alpha-synuclein oligomers") increases bp(GO:"cell death") |
| pubmed:30985105 | a(CONSO:"alpha-synuclein oligomers") negativeCorrelation a(CONSO:"alpha-synuclein aggregates") |
| pubmed:29758300 | complex(p(HGNC:LAMP2), p(HGNC:SNCA, var("p.Ala53Thr"))) decreases bp(GO:"lysosomal protein catabolic process") |
| pubmed:29758300 | complex(p(HGNC:LAMP2), p(HGNC:SNCA, var("p.Ala30Pro"))) decreases bp(GO:"lysosomal protein catabolic process") |
| pubmed:14556719 | p(HGNC:SNCA, var("p.Ala30Pro")) association path(MESH:"Parkinson Disease") |
| pubmed:28803412 | p(HGNC:SNCA, var("p.Ala30Pro")) increases path(MESH:"Parkinson Disease") |
| pubmed:14556719 | p(HGNC:SNCA, var("p.Ala30Pro")) increases a(CONSO:"alpha-synuclein fibrils") |
| pubmed:28803412 | p(HGNC:SNCA, var("p.Ala30Pro")) increases path(MESH:"Lewy Body Disease") |
| pubmed:29758300 | p(HGNC:TARDBP, pmod(CONSO:misfolding)) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:29758300 | p(HGNC:TARDBP, pmod(CONSO:misfolding)) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation")) association p(HGNC:GSK3A) |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation")) increases p(CONSO:"TDP-43 aggregates") |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) association path(MESH:"Lewy Body Disease") |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) association path(MESH:"Supranuclear Palsy, Progressive") |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) association path(MESH:"Pick Disease of the Brain") |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) association path(MESH:Sclerosis) |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) association path(MESH:"Alzheimer Disease") |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) association path(MESH:"Huntington Disease") |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) association path(MESH:"Parkinson Disease") |
| pubmed:29758300 | a(CHEBI:lipid) regulates bp(GO:"energy homeostasis") |
| pubmed:29758300 | a(CHEBI:lipid) regulates bp(GO:"intracellular signal transduction") |
| pubmed:29758300 | a(CHEBI:lipid) regulates bp(GO:macroautophagy) |
| pubmed:29758300 | a(CHEBI:lipid) regulates bp(GO:"amyloid-beta metabolic process") |
| pubmed:29758300 | a(CHEBI:lipid) negativeCorrelation bp(GO:autophagy) |
| pubmed:22908190 | a(CHEBI:lipid) positiveCorrelation act(p(HGNC:RAB5A)) |
| pubmed:22908190 | a(CHEBI:lipid) positiveCorrelation bp(GO:endocytosis) |
| pubmed:24561250 | a(CHEBI:"fatty acid") increases act(complex(GO:"inflammasome complex")) |
| pubmed:29758300 | a(CHEBI:sphingolipid) association path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | a(CHEBI:sphingolipid) regulates act(complex(GO:"gamma-secretase complex")) |
| pubmed:29758300 | a(CHEBI:sphingolipid) association bp(GO:"amyloid-beta metabolic process") |
| pubmed:29758300 | rxn(reactants(a(MESH:Sphingomyelins)), products(a(CHEBI:ceramide))) increases a(CHEBI:amyloid-beta) |
| pubmed:29758300 | complex(a(CHEBI:lipid), p(HGNC:MAPT)) increases a(CONSO:"Tau aggregates") |
| pubmed:29758300 | complex(a(MESH:"Lipid Bilayers"), p(HGNC:MAPT)) association a(CONSO:"Tau aggregates") |
| pubmed:29758300 | p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23528736 | p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30116051 | p(FPLX:AMPK) increases bp(GO:macroautophagy) |
| pubmed:30116051 | act(p(FPLX:AMPK)) increases bp(GO:macroautophagy) |
| pubmed:30116051 | act(p(FPLX:AMPK)) increases bp(GO:macroautophagy) |
| pubmed:30116051 | p(FPLX:AMPK) decreases bp(GO:mitophagy) |
| pubmed:30116051 | p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation", Ser, 317)) |
| pubmed:30116051 | p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation", Ser, 777)) |
| pubmed:30116051 | p(FPLX:AMPK) increases p(FPLX:mTORC1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30116051 | p(FPLX:AMPK) increases a(CHEBI:"NAD(+)") |
| pubmed:30116051 | act(p(FPLX:AMPK)) increases bp(GO:autophagy) |
| pubmed:23528736 | p(FPLX:AMPK) increases bp(GO:autophagy) |
| pubmed:30116051 | act(p(FPLX:AMPK)) increases act(p(HGNC:SIRT1)) |
| pubmed:23528736 | p(FPLX:AMPK) decreases act(p(FPLX:mTORC1)) |
| pubmed:22419736 | act(p(FPLX:AMPK)) association p(MESH:"Acetyl-CoA Carboxylase") |
| pubmed:22419736 | act(p(FPLX:AMPK)) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22419736 | p(FPLX:AMPK) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22419736 | act(p(FPLX:AMPK)) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:22419736 | act(p(FPLX:AMPK)) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:22419736 | act(p(FPLX:AMPK)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:22419736 | act(p(FPLX:AMPK)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:22419736 | act(p(FPLX:AMPK)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:22419736 | act(p(FPLX:AMPK)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:22419736 | p(FPLX:AMPK) negativeCorrelation act(p(HGNC:GSK3B)) |
| pubmed:24869773 | p(FPLX:AMPK) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:29758300 | composite(p(FPLX:AMPK), p(HGNC:TSC2)) decreases act(p(HGNC:MTOR)) |
| pubmed:29758300 | p(FPLX:mTORC1) increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29758300 | p(FPLX:mTORC1) decreases act(p(HGNC:TFEB)) |
| pubmed:30116051 | p(FPLX:mTORC1) decreases tloc(p(HGNC:TFEB), fromLoc(MESH:Cytoplasm), toLoc(MESH:"Cell Nucleus")) |
| pubmed:30116051 | act(p(FPLX:mTORC1)) increases act(p(HGNC:TFEB)) |
| pubmed:30116051 | p(FPLX:mTORC1) increases bp(GO:macroautophagy) |
| pubmed:30116051 | p(FPLX:mTORC1) decreases bp(GO:macroautophagy) |
| pubmed:30116051 | p(FPLX:mTORC1) decreases bp(GO:macroautophagy) |
| pubmed:30116051 | p(FPLX:mTORC1) increases bp(GO:macroautophagy) |
| pubmed:30116051 | p(FPLX:mTORC1) decreases bp(GO:mitophagy) |
| pubmed:30116051 | p(FPLX:mTORC1) increases p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation", Ser, 757)) |
| pubmed:30116051 | act(p(FPLX:mTORC1)) increases act(p(HGNC:NFE2L2)) |
| pubmed:30116051 | p(FPLX:mTORC1) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:30116051 | p(FPLX:mTORC1) decreases bp(GO:"proteasome assembly") |
| pubmed:23528736 | p(FPLX:mTORC1) decreases bp(GO:autophagy) |
| pubmed:23528736 | act(p(FPLX:mTORC1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23528736 | act(p(FPLX:mTORC1)) increases p(HGNC:MAPT) |
| pubmed:30108137 | act(p(FPLX:mTORC1)) increases p(MGI:Tfeb, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29758300 | complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) increases bp(GO:macroautophagy) |
| pubmed:29758300 | complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) increases a(GO:lysosome) |
| pubmed:29758300 | composite(p(HGNC:PTEN), p(HGNC:TFEB)) increases bp(GO:macroautophagy) |
| pubmed:29758300 | p(HGNC:PICALM, var("?")) association path(MESH:"Alzheimer Disease") |
| pubmed:26195256 | p(HGNC:PICALM, var("?")) association path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | p(HGNC:TREM2, var("?")) increases path(MESH:"Alzheimer Disease") |
| pubmed:26195256 | p(HGNC:TREM2, var("?")) association path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | p(HGNC:VPS35) regulates act(p(HGNC:TREM2)) |
| pubmed:29758300 | p(HGNC:VPS35) directlyIncreases complex(p(HGNC:SORL1), p(HGNC:VPS35)) |
| pubmed:29758300 | p(HGNC:VPS35, var("?")) decreases bp(GO:macroautophagy) |
| pubmed:29758300 | p(HGNC:VPS35, var("?")) decreases act(a(GO:mitochondrion)) |
| pubmed:29758300 | p(HGNC:VPS35, var("?")) association path(MESH:"Alzheimer Disease") |
| pubmed:29758300 | p(HGNC:VPS35, var("?")) association path(MESH:"Parkinson Disease") |
| pubmed:29758300 | a(GO:mitochondrion) regulates bp(GO:"energy homeostasis") |
| pubmed:23528736 | act(a(GO:mitochondrion)) increases a(CHEBI:"reactive oxygen species") |
| pubmed:25987199 | act(a(GO:mitochondrion)) positiveCorrelation act(p(MGI:Ppargc1a)) |
| pubmed:29758300 | p(HGNC:PSEN1, var("p.Met146Leu")) decreases bp(GO:autophagy) |
| pubmed:29758300 | p(HGNC:MAPT, var("p.Ala152Thr")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29758300 | p(HGNC:MAPT, var("p.Ala152Thr")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:29758300 | p(HGNC:MAPT, var("p.Ala152Thr")) increases bp(GO:macroautophagy) |
| pubmed:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases p(HGNC:MAP2) |
| pubmed:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange a(GO:"symmetric, GABA-ergic, inhibitory synapse") |
| pubmed:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:SLC17A7) |
| pubmed:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:MAPT) |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Ala152Thr")) decreases act(p(HGNC:MAPT)) |
| pubmed:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:DLGAP4) |
| pubmed:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange bp(MESH:"Membrane Potentials") |
| pubmed:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange bp(GO:"neuron differentiation") |
| pubmed:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) |
| pubmed:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases tloc(p(HGNC:MMP9), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases tloc(p(HGNC:MMP9), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) |
| pubmed:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases tloc(p(HGNC:MMP9), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases tloc(p(HGNC:MMP2), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP2)) |
| pubmed:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases tloc(p(HGNC:MMP2), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP9) |
| pubmed:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP9) |
| pubmed:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP2) |
| pubmed:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP2) |
| pubmed:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases bp(GO:"neuron death") |
| pubmed:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases p(FPLX:ERK, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases p(CONSO:CONSO00045) |
| pubmed:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) decreases p(CONSO:CONSO00044) |
| pubmed:29024336 | p(HGNC:MAPT, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) |
| pubmed:29191965 | p(HGNC:MAPT, var("p.Ala152Thr")) association path(MESH:"Supranuclear Palsy, Progressive") |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Ala152Thr")) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Ala152Thr")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Ala152Thr")) decreases bp(GO:"microtubule polymerization") |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Ala152Thr")) increases a(CONSO:"Tau oligomers") |
| pubmed:29758300 | composite(a(CHEBI:sirolimus), p(HGNC:MAPT, var("p.Ala152Thr"))) increases bp(GO:"cell death") |
| pubmed:27594586 | composite(a(CHEBI:sirolimus), p(HGNC:MAPT, var("p.Ala152Thr"))) increases bp(GO:"neuron death") |
| pubmed:29758300 | path(MESH:"Niemann-Pick Disease, Type C") negativeCorrelation bp(GO:macroautophagy) |
| pubmed:29758300 | path(MESH:"Spastic Paraplegia, Hereditary") negativeCorrelation bp(GO:macroautophagy) |
| pubmed:29758300 | a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:macroautophagy) |
| pubmed:30116051 | a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:macroautophagy) |
| pubmed:18930136 | a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) |
| pubmed:30145931 | a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) |
| pubmed:23528736 | a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) |
| pubmed:29626319 | a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) |
| pubmed:29626319 | a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) |
| pubmed:27181519 | a(CHEBI:"alpha,alpha-trehalose") association bp(GO:autophagy) |
| pubmed:18930136 | a(CHEBI:"alpha,alpha-trehalose") decreases path(CONSO:Neurodegeneration) |
| pubmed:30145931 | a(CHEBI:"alpha,alpha-trehalose") decreases p(HGNC:MAPT) |
| pubmed:30145931 | a(CHEBI:"alpha,alpha-trehalose") decreases p(HGNC:MAPT, loc(MESH:Dendrites)) |
| pubmed:29626319 | a(CHEBI:"alpha,alpha-trehalose") decreases p(HGNC:MAPT) |
| pubmed:30145931 | a(CHEBI:"alpha,alpha-trehalose") decreases a(CONSO:"Tau aggregates") |
| pubmed:30116051 | a(CHEBI:"alpha,alpha-trehalose") decreases a(CONSO:"Tau aggregates") |
| pubmed:23528736 | a(CHEBI:"alpha,alpha-trehalose") decreases a(CONSO:"Tau aggregates") |
| pubmed:30116051 | a(CHEBI:"alpha,alpha-trehalose") decreases act(p(HGNC:SLC2A9)) |
| pubmed:30116051 | a(CHEBI:"alpha,alpha-trehalose") increases act(p(FPLX:AMPK)) |
| pubmed:30116051 | a(CHEBI:"alpha,alpha-trehalose") decreases bp(HP:Neurodegeneration) |
| pubmed:30116051 | a(CHEBI:"alpha,alpha-trehalose") decreases a(CONSO:"alpha-synuclein aggregates") |
| pubmed:30116051 | a(CHEBI:"alpha,alpha-trehalose") decreases a(CONSO:"huntingtin aggregates") |
| pubmed:30116051 | a(CHEBI:"alpha,alpha-trehalose") decreases a(CONSO:"amyloid-beta aggregates") |
| pubmed:30116051 | a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:"motor behavior") |
| pubmed:30116051 | a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:cognition) |
| pubmed:23528736 | a(CHEBI:"alpha,alpha-trehalose") decreases bp(GO:"neuron apoptotic process") |
| pubmed:29626319 | a(CHEBI:"alpha,alpha-trehalose") decreases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | a(CHEBI:"alpha,alpha-trehalose") increases p(HGNC:BAG3) |
| pubmed:29758300 | a(CHEBI:epothilone) decreases path(MESH:Tauopathies) |
| pubmed:29758300 | a(CHEBI:epothilone) increases bp(GO:cognition) |
| pubmed:14556719 | composite(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) |
| pubmed:22908190 | composite(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) |
| pubmed:14556719 | act(p(HGNC:UBA1)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:18930136 | p(HGNC:UBA1) increases bp(GO:autophagy) |
| pubmed:18930136 | p(HGNC:UBA1) increases bp(GO:"protein ubiquitination") |
| pubmed:29626319 | p(HGNC:UBA1) increases deg(a(MESH:Proteins)) |
| pubmed:14556719 | act(a(MESH:Ubiquitin)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) |
| pubmed:22908190 | act(a(MESH:Ubiquitin)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) |
| pubmed:22908190 | a(MESH:Ubiquitin) association a(CONSO:"paired helical filaments") |
| pubmed:22908190 | a(MESH:Ubiquitin) association a(GO:"neurofibrillary tangle") |
| pubmed:22908190 | a(MESH:Ubiquitin) association a(CONSO:"dystrophic neurite") |
| pubmed:22908190 | a(MESH:Ubiquitin) association path(CONSO:"granulovacuolar degeneration") |
| pubmed:22908190 | a(MESH:Ubiquitin) association path(CONSO:"granulovacuolar degeneration") |
| pubmed:22908190 | a(MESH:Ubiquitin) association a(MESH:"Neuropil Threads") |
| pubmed:22908190 | a(MESH:Ubiquitin) association a(GO:"Lewy body") |
| pubmed:22908190 | a(MESH:Ubiquitin) association a(GO:"Lewy body") |
| pubmed:22908190 | a(MESH:Ubiquitin) association a(GO:"Pick body") |
| pubmed:22908190 | a(MESH:Ubiquitin) increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:"multivesicular body")) |
| pubmed:24457024 | a(MESH:Ubiquitin) regulates bp(GO:signaling) |
| pubmed:24457024 | a(MESH:Ubiquitin) regulates bp(GO:endocytosis) |
| pubmed:24457024 | a(MESH:Ubiquitin) regulates bp(GO:macroautophagy) |
| pubmed:24457024 | a(MESH:Ubiquitin) regulates bp(GO:"DNA repair") |
| pubmed:24457024 | act(a(MESH:Ubiquitin)) regulates bp(GO:"cellular homeostasis") |
| pubmed:24457024 | complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) |
| pubmed:24457024 | complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) |
| pubmed:14556719 | p(HGNC:UBA2) decreases complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) |
| pubmed:14556719 | p(HGNC:UBA2) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) |
| pubmed:14556719 | p(HGNC:UBA2) increases complex(a(MESH:Ubiquitin), p(INTERPRO:"HECT domain")) |
| pubmed:14556719 | act(p(HGNC:UBA2)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:14556719 | p(HGNC:UBA2) increases p(HGNC:HTT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:24457024 | p(HGNC:UBA2) increases bp(GO:"protein ubiquitination") |
| pubmed:24457024 | complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) increases act(p(HGNC:UBA2)) |
| pubmed:14556719 | p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") |
| pubmed:14556719 | p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") |
| pubmed:24457024 | p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") |
| pubmed:24457024 | p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") |
| pubmed:24457024 | p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") |
| pubmed:14556719 | p(HGNC:UBA3) association bp(GO:proteolysis) |
| pubmed:22908190 | p(HGNC:UBA3) increases complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA2), p(HGNC:UBA3)) |
| pubmed:24457024 | p(HGNC:UBA3) increases act(p(HGNC:UBA2)) |
| pubmed:24457024 | p(HGNC:UBA3) regulates complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) |
| pubmed:24457024 | p(HGNC:UBA3) regulates bp(GO:"protein polyubiquitination") |
| pubmed:24457024 | p(INTERPRO:"HECT domain") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) |
| pubmed:14556719 | p(INTERPRO:"E3 ubiquitin ligase RBR family") decreases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) |
| pubmed:14556719 | p(INTERPRO:"E3 ubiquitin ligase RBR family") increases complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA3)) |
| pubmed:24457024 | p(INTERPRO:"E3 ubiquitin ligase RBR family") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) |
| pubmed:24457024 | complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) increases act(p(HGNC:UBA2)) |
| pubmed:14556719 | bp(GO:"protein K48-linked ubiquitination") increases act(complex(GO:"proteasome complex")) |
| pubmed:14556719 | bp(GO:"protein K63-linked ubiquitination") increases act(complex(GO:"proteasome complex")) |
| pubmed:22908190 | bp(GO:"protein K63-linked ubiquitination") association a(GO:"neurofibrillary tangle") |
| pubmed:18930136 | bp(GO:"protein K63-linked ubiquitination") increases act(p(HGNC:SQSTM1)) |
| pubmed:18930136 | bp(GO:"protein K63-linked ubiquitination") increases act(p(HGNC:HDAC6)) |
| pubmed:18930136 | bp(GO:"protein K63-linked ubiquitination") increases bp(GO:autophagy) |
| pubmed:14556719 | p(HGNC:MOCS3) increases bp(GO:"protein polyubiquitination") |
| pubmed:22908190 | p(CONSO:"20 S Proteasome") increases deg(p(HGNC:MAPT)) |
| pubmed:22908190 | p(CONSO:"20 S Proteasome") increases complex(a(CONSO:"Tau aggregates"), p(CONSO:"20 S Proteasome")) |
| pubmed:16816118 | act(p(CONSO:"20 S Proteasome")) increases deg(p(RGD:Mapt, pmod(CONSO:hyperphosphorylation))) |
| pubmed:16816118 | act(p(CONSO:"20 S Proteasome")) increases deg(p(RGD:Mapt)) |
| pubmed:14556719 | complex(GO:"proteasome regulatory particle") increases bp(GO:"protein unfolding") |
| pubmed:14556719 | p(HGNC:PSMD4) increases complex(a(MESH:Ubiquitin), p(HGNC:PSMD4)) |
| pubmed:14556719 | p(HGNC:PSMD4) association p(HGNC:PRKN) |
| pubmed:24457024 | p(HGNC:PSMD4) increases complex(a(GO:"proteasome complex"), p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"))) |
| pubmed:25036637 | p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMD4), p(HGNC:USP14)) |
| pubmed:25036637 | p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMC1), p(HGNC:PSMD4)) |
| pubmed:25036637 | p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMD2), p(HGNC:PSMD4)) |
| pubmed:25036637 | p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PRPS2), p(HGNC:PSMD4)) |
| pubmed:25036637 | p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMA5), p(HGNC:PSMD4)) |
| pubmed:14556719 | p(HGNC:PSMC3) increases complex(a(MESH:Ubiquitin), p(HGNC:PSMC3)) |
| pubmed:14556719 | deg(complex(a(MESH:Proteins), a(MESH:Ubiquitin))) increases a(CHEBI:peptide) |
| pubmed:14556719 | deg(complex(a(MESH:Proteins), a(MESH:Ubiquitin))) increases a(MESH:Ubiquitin) |
| pubmed:14556719 | complex(a(MESH:"Molecular Chaperones"), a(MESH:Proteins)) increases bp(GO:"protein stabilization") |
| pubmed:27181519 | bp(GO:"DNA repair") association p(HGNC:FUS) |
| pubmed:25036637 | bp(GO:"gene silencing") association p(HGNC:DCP1A) |
| pubmed:25036637 | bp(GO:"gene silencing") association p(HGNC:EDC3) |
| pubmed:25036637 | bp(GO:"gene silencing") association p(HGNC:DDX6) |
| pubmed:14556719 | path(MESH:Sepsis) increases bp(GO:"protein catabolic process") |
| pubmed:14556719 | path(MESH:Acidosis) increases bp(GO:"protein catabolic process") |
| pubmed:14556719 | a(MESH:Denervation) increases bp(GO:"protein catabolic process") |
| pubmed:14556719 | p(HGNC:NEDD8) increases complex(a(GO:"SCF ubiquitin ligase complex"), p(HGNC:UBA2)) |
| pubmed:14556719 | p(HGNC:SUMO1) increases p(HGNC:NFKBIA, pmod(go:0016925 ! "protein sumoylation")) |
| pubmed:27716675 | p(HGNC:SUMO1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23229893 | p(HGNC:SUMO1) association a(GO:lysosome) |
| pubmed:19323834 | p(HGNC:SUMO1) partOf complex(p(FPLX:CEBP), p(HGNC:SUMO1)) |
| pubmed:18675254 | p(HGNC:SUMO1) increases p(HGNC:APP, pmod(go:0016925 ! "protein sumoylation", Lys, 587)) |
| pubmed:18675254 | p(HGNC:SUMO1) increases p(HGNC:APP, pmod(go:0016925 ! "protein sumoylation", Lys, 595)) |
| pubmed:16464864 | p(HGNC:SUMO1) increases p(HGNC:MAPT, pmod(go:0016925 ! "protein sumoylation", Lys, 340)) |
| pubmed:16464864 | p(HGNC:SUMO1) increases p(HGNC:SNCA, pmod(go:0016925 ! "protein sumoylation")) |
| pubmed:14556719 | p(HGNC:NFKBIA, pmod(go:0016925 ! "protein sumoylation")) decreases bp(GO:"protein ubiquitination") |
| pubmed:14556719 | p(UNIPROT:P32628) increases tloc(p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination")), fromLoc(GO:cytosol), toLoc(GO:"proteasome complex")) |
| pubmed:14556719 | p(UNIPROT:P48510) increases tloc(p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination")), fromLoc(GO:cytosol), toLoc(GO:"proteasome complex")) |
| pubmed:14556719 | complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(MESH:"Neurofibrillary Tangles") |
| pubmed:14556719 | complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(GO:"Bunina body") |
| pubmed:14556719 | complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Huntington Disease") |
| pubmed:14556719 | complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Spinocerebellar Ataxias") |
| pubmed:14556719 | complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") |
| pubmed:14556719 | complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(MESH:"Lewy Bodies") |
| pubmed:14556719 | a(MESH:"Inclusion Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders") |
| pubmed:14556719 | a(MESH:"Inclusion Bodies") association p(HGNC:SNCA) |
| pubmed:14556719 | a(MESH:"Inclusion Bodies") association p(HGNC:CREBBP) |
| pubmed:30837838 | a(MESH:"Inclusion Bodies") association p(HGNC:TARDBP, frag("274_414")) |
| pubmed:14556719 | complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(MESH:"Neurofibrillary Tangles") |
| pubmed:14556719 | complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(GO:"Bunina body") |
| pubmed:14556719 | complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Huntington Disease") |
| pubmed:14556719 | complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Spinocerebellar Ataxias") |
| pubmed:14556719 | complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") |
| pubmed:14556719 | complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(MESH:"Lewy Bodies") |
| pubmed:14556719 | path(MESH:"Spinocerebellar Ataxias") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) |
| pubmed:14556719 | path(MESH:"Spinocerebellar Ataxias") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) |
| pubmed:14556719 | a(MESH:"Lewy Bodies") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) |
| pubmed:14556719 | a(MESH:"Lewy Bodies") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) |
| pubmed:14556719 | a(MESH:"Lewy Bodies") association a(GO:"dopaminergic synapse") |
| pubmed:14556719 | a(MESH:"Lewy Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders") |
| pubmed:14556719 | a(MESH:"Lewy Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders") |
| pubmed:14556719 | a(MESH:"Lewy Bodies") association a(CONSO:"alpha-synuclein aggregates") |
| pubmed:14556719 | a(MESH:"Lewy Bodies") association path(MESH:"Parkinson Disease") |
| pubmed:14556719 | path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Lewy Bodies") |
| pubmed:14556719 | path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Lewy Bodies") |
| pubmed:14556719 | path(MESH:"Parkinsonian Disorders") positiveCorrelation p(HGNC:GPR37) |
| pubmed:14556719 | path(MESH:"Parkinsonian Disorders") association p(HGNC:SNCA, var("?")) |
| pubmed:14556719 | path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Inclusion Bodies") |
| pubmed:14556719 | path(MESH:"Parkinsonian Disorders") association p(HGNC:PRKN, var("p.Lys161Asn")) |
| pubmed:14556719 | path(MESH:"Parkinsonian Disorders") positiveCorrelation a(CONSO:"alpha-synuclein aggregates") |
| pubmed:14556719 | path(MESH:"Parkinsonian Disorders") increases path(CONSO:Neurodegeneration) |
| pubmed:14556719 | path(MESH:"Parkinsonian Disorders") association g(HGNC:PARK7, var("?")) |
| pubmed:14556719 | path(MESH:"Parkinsonian Disorders") association p(HGNC:PARK7, var("p.Leu166Pro")) |
| pubmed:30126037 | path(MESH:"Parkinsonian Disorders") association path(MESH:"Supranuclear Palsy, Progressive") |
| pubmed:14556719 | p(HGNC:PRKN, var("p.Arg42?")) decreases complex(a(GO:"proteasome complex"), p(HGNC:PRKN)) |
| pubmed:14556719 | p(HGNC:PRKN, var("p.Arg42?")) increases path(MESH:"Parkinsonian Disorders") |
| pubmed:14556719 | complex(a(GO:"proteasome complex"), p(HGNC:PRKN)) decreases path(MESH:"Parkinsonian Disorders") |
| pubmed:14556719 | p(INTERPRO:"IBR domain", var("?")) decreases act(p(HGNC:PRKN)) |
| pubmed:14556719 | complex(p(HGNC:PRKN), p(HGNC:STUB1)) increases act(p(HGNC:PRKN)) |
| pubmed:14556719 | complex(p(HGNC:SEPT5), p(HGNC:STX1A)) decreases bp(GO:exocytosis) |
| pubmed:29191965 | a(GO:"synaptic vesicle") association complex(p(HGNC:KLC3), p(HGNC:MAPT)) |
| pubmed:14556719 | p(HGNC:GPR37) association p(HGNC:PRKN) |
| pubmed:14556719 | p(HGNC:GPR37) increases p(HGNC:GPR37, pmod(CONSO:misfolding)) |
| pubmed:14556719 | p(HGNC:GPR37) positiveCorrelation bp(GO:"cell death") |
| pubmed:14556719 | p(HGNC:GPR37) positiveCorrelation path(MESH:"Parkinsonian Disorders") |
| pubmed:14556719 | bp(GO:"response to unfolded protein") increases bp(GO:"cell death") |
| pubmed:14556719 | bp(GO:"response to unfolded protein") increases bp(GO:"response to endoplasmic reticulum stress") |
| pubmed:14556719 | bp(GO:"response to unfolded protein") increases a(MESH:"Molecular Chaperones") |
| pubmed:14556719 | bp(GO:"response to unfolded protein") positiveCorrelation bp(MESH:"Osmolar Concentration") |
| pubmed:23746257 | bp(GO:"response to unfolded protein") regulates bp(CONSO:Proteostasis) |
| pubmed:14556719 | p(MESH:Proteins, var("?")) increases bp(GO:"response to unfolded protein") |
| pubmed:14556719 | composite(p(HGNC:PRKN), p(HGNC:UBE2G1), p(HGNC:UBE2J1)) increases deg(p(HGNC:GPR37)) |
| pubmed:14556719 | a(CHEBI:"alkylating agent") increases bp(GO:"response to unfolded protein") |
| pubmed:14556719 | bp(MESH:"Ultraviolet Rays") increases bp(GO:"response to unfolded protein") |
| pubmed:14556719 | p(HGNC:SNCA, pmod(go:0006493 ! "protein O-linked glycosylation")) association p(HGNC:PRKN) |
| pubmed:14556719 | p(HGNC:SNCAIP) association p(HGNC:SNCA) |
| pubmed:14556719 | composite(p(HGNC:SNCA), p(HGNC:SNCAIP)) increases a(MESH:"Inclusion Bodies") |
| pubmed:14556719 | p(HGNC:CCNE1) association p(HGNC:PRKN) |
| pubmed:14556719 | p(HGNC:CCNE1) positiveCorrelation bp(GO:"neuron apoptotic process") |
| pubmed:14556719 | composite(a(PUBCHEM:164810), p(HGNC:PRKN)) decreases p(HGNC:CCNE1) |
| pubmed:14556719 | p(HGNC:AIMP2) increases bp(GO:"cell death") |
| pubmed:14556719 | p(HGNC:PRKN, var("p.Lys161Asn")) association path(MESH:"Parkinsonian Disorders") |
| pubmed:14556719 | p(HGNC:PRKN, var("p.Lys161Asn")) increases p(HGNC:AIMP2, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:14556719 | p(HGNC:SYT11, pmod(go:0016567 ! "protein ubiquitination")) association bp(GO:"synaptic vesicle transport") |
| pubmed:14556719 | p(HGNC:SYT11, pmod(go:0016567 ! "protein ubiquitination")) association tloc(a(CHEBI:neurotransmitter), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:14556719 | a(GO:"actin filament") association p(HGNC:PRKN) |
| pubmed:14556719 | p(HGNC:UBE3A) increases complex(a(CONSO:"protein aggregates"), a(MESH:Neurons)) |
| pubmed:14556719 | act(p(HGNC:UBE3A)) decreases bp(GO:"cell death") |
| pubmed:22908190 | p(HGNC:UBE3A) increases deg(p(HGNC:ARC)) |
| pubmed:14556719 | p(HGNC:UCHL1, var("p.Ile93Met")) association path(MESH:"Parkinson Disease") |
| pubmed:14556719 | complex(p(HGNC:UCHL1), p(HGNC:UCHL1)) increases bp(GO:"protein K63-linked ubiquitination") |
| pubmed:22908190 | p(HGNC:SNCA, pmod(go:0016567 ! "protein ubiquitination")) positiveCorrelation p(HGNC:SNCA) |
| pubmed:22908190 | p(HGNC:SNCA, pmod(go:0016567 ! "protein ubiquitination")) positiveCorrelation path(MESH:"Parkinson Disease") |
| pubmed:22908190 | p(HGNC:SNCA, pmod(go:0016567 ! "protein ubiquitination")) positiveCorrelation path(MESH:Dementia) |
| pubmed:14556719 | p(HGNC:UCHL3) decreases path(MESH:"Deglutition Disorders") |
| pubmed:14556719 | p(HGNC:UCHL3) positiveCorrelation a(MESH:"Solitary Nucleus") |
| pubmed:14556719 | p(HGNC:UCHL3) positiveCorrelation a(MESH:"Area Postrema") |
| pubmed:14556719 | a(MESH:"Solitary Nucleus") positiveCorrelation p(HGNC:UCHL1) |
| pubmed:14556719 | a(MESH:"Solitary Nucleus") positiveCorrelation p(HGNC:UCHL3) |
| pubmed:14556719 | a(MESH:"Area Postrema") positiveCorrelation p(HGNC:UCHL1) |
| pubmed:14556719 | a(MESH:"Area Postrema") positiveCorrelation p(HGNC:UCHL3) |
| pubmed:14556719 | bp(CONSO:"Alpha-synuclein Oligomerization") positiveCorrelation p(HGNC:SNCA) |
| pubmed:14556719 | bp(CONSO:"Alpha-synuclein Oligomerization") increases a(CONSO:"alpha-synuclein fibrils") |
| pubmed:14556719 | a(CONSO:"alpha-synuclein fibrils") increases a(CONSO:"alpha-synuclein aggregates") |
| pubmed:14556719 | p(HGNC:SNCA, pmod(go:0006486 ! "protein glycosylation")) association p(HGNC:PRKN) |
| pubmed:14556719 | complex(a(CONSO:"alpha-synuclein aggregates"), p(HGNC:PSMC4)) decreases act(complex(GO:"proteasome complex")) |
| pubmed:14556719 | complex(p(HGNC:PSMC4), p(HGNC:SNCA)) decreases act(complex(GO:"proteasome complex")) |
| pubmed:14556719 | p(HGNC:PARK7, pmod(go:0016925 ! "protein sumoylation")) regulates act(p(HGNC:PARK7)) |
| pubmed:14556719 | complex(p(HGNC:PARK7), p(HGNC:PIAS2)) increases p(HGNC:PARK7, pmod(go:0016925 ! "protein sumoylation")) |
| pubmed:14556719 | p(HGNC:PARK7, var("p.Leu166Pro")) association path(MESH:"Parkinsonian Disorders") |
| pubmed:14556719 | p(HGNC:PARK7, var("p.Leu166Pro")) increases deg(p(HGNC:PARK7)) |
| pubmed:14556719 | p(HGNC:PARK7, var("p.Leu166Pro")) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:14556719 | p(HGNC:CFTR, var("p.Phe508del")) increases deg(p(HGNC:CFTR)) |
| pubmed:14556719 | p(HGNC:CFTR, var("p.Phe508del")) increases path(MESH:"Cystic Fibrosis") |
| pubmed:14556719 | deg(p(HGNC:CFTR)) increases path(MESH:"Cystic Fibrosis") |
| pubmed:30837838 | p(HGNC:CFTR) association act(p(HGNC:TARDBP), ma(MESH:"RNA Splicing")) |
| pubmed:29311797 | path(MESH:"Cystic Fibrosis") association p(HGNC:STUB1) |
| pubmed:29311797 | path(MESH:"Cystic Fibrosis") association p(HGNC:AHSA1) |
| pubmed:14556719 | p(HGNC:SEC61A1) increases tloc(p(MESH:Proteins, pmod(CONSO:misfolding)), fromLoc(GO:"endoplasmic reticulum lumen"), toLoc(GO:cytosol)) |
| pubmed:14556719 | g(HGNC:MAPT, var("?")) increases path(MESH:"Pick Disease of the Brain") |
| pubmed:14556719 | composite(a(CHEBI:amyloid-beta), p(HGNC:MAPT, var("?"))) increases path(MESH:"Alzheimer Disease") |
| pubmed:14556719 | a(CHEBI:lactacystin) decreases act(complex(GO:"proteasome complex")) |
| pubmed:14556719 | a(CHEBI:lactacystin) increases bp(GO:"cell death") |
| pubmed:22908190 | a(CHEBI:lactacystin) decreases bp(GO:"long-term memory") |
| pubmed:30145931 | a(CHEBI:lactacystin) decreases act(p(FPLX:Proteasome)) |
| pubmed:23528736 | a(CHEBI:lactacystin) decreases act(p(FPLX:Proteasome)) |
| pubmed:24027553 | a(CHEBI:lactacystin) decreases deg(p(HGNC:MAPT)) |
| pubmed:24027553 | a(CHEBI:lactacystin) increases p(HGNC:MAPT) |
| pubmed:23528736 | a(CHEBI:lactacystin) decreases deg(p(HGNC:MAPT)) |
| pubmed:24027553 | a(CHEBI:lactacystin) decreases act(p(CONSO:"20 S Proteasome")) |
| pubmed:24027553 | a(CHEBI:lactacystin) increases p(HGNC:MAPT, var("p.Pro301Leu")) |
| pubmed:24027553 | a(CHEBI:lactacystin) decreases act(p(HGNCGENEFAMILY:Proteasome)) |
| pubmed:14556719 | a(MESH:Prions) increases path(MESH:"Prion Diseases") |
| pubmed:14556719 | a(MESH:Prions) increases path(MESH:"Encephalopathy, Bovine Spongiform") |
| pubmed:30837838 | a(CHEBI:"copper(2+)") causesNoChange a(MESH:"Inclusion Bodies") |
| pubmed:30837838 | a(CHEBI:"copper(2+)") causesNoChange path(MESH:"Protein Aggregation, Pathological") |
| pubmed:14556719 | complex(p(HGNC:HSPA5), p(HGNC:PRNP)) increases bp(GO:"protein folding") |
| pubmed:14556719 | p(HGNC:SOD1, pmod(CONSO:misfolding)) increases a(CONSO:"protein aggregates") |
| pubmed:14556719 | p(HGNC:RNF19A) decreases bp(GO:"cell death") |
| pubmed:14556719 | p(HGNC:RNF19A) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:14556719 | p(HGNC:RNF19A) increases deg(p(HGNC:SOD1, var("?"))) |
| pubmed:14556719 | p(HGNC:UBL5) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:14556719 | composite(a(CHEBI:lactacystin), p(HGNC:SOD1, var("?"))) increases bp(GO:"cell death") |
| pubmed:14556719 | p(HGNC:CDC34, var("?")) decreases a(MESH:"Inclusion Bodies") |
| pubmed:14556719 | p(HGNC:CDC34, var("?")) increases bp(GO:"cell death") |
| pubmed:24457024 | p(HGNC:CDC34) increases complex(a(MESH:Ubiquitin), p(HGNC:CDC34)) |
| pubmed:14556719 | p(HGNC:RAD23A) increases tloc(p(HGNC:ATXN3, pmod(go:0016567 ! "protein ubiquitination")), fromLoc(GO:cytosol), toLoc(GO:"proteasome complex")) |
| pubmed:14556719 | composite(a(CHEBI:cystamine), p(HGNC:ATN1)) decreases a(CONSO:"protein aggregates") |
| pubmed:14556719 | composite(a(CHEBI:cystamine), p(HGNC:ATN1)) decreases bp(GO:"cell death") |
| pubmed:14556719 | composite(a(CHEBI:cystamine), p(HGNC:AR, var("?"))) decreases a(CONSO:"protein aggregates") |
| pubmed:14556719 | composite(a(CHEBI:cystamine), p(HGNC:AR, var("?"))) decreases bp(GO:"cell death") |
| pubmed:14556719 | a(CHEBI:"Congo Red") decreases a(CONSO:"huntingtin aggregates") |
| pubmed:14556719 | a(CHEBI:"Congo Red") increases act(complex(GO:"proteasome complex")) |
| pubmed:22908190 | p(FPLX:Caspase) increases deg(p(HGNC:MAPT)) |
| pubmed:29626319 | p(FPLX:Caspase) increases deg(p(HGNC:MAPT)) |
| pubmed:25374103 | p(FPLX:Caspase) increases path(MESH:Tauopathies) |
| pubmed:26631930 | p(FPLX:Caspase) increases p(HGNC:MAPT, frag("26_230")) |
| pubmed:22908190 | composite(a(MESH:Ubiquitin), p(HGNC:SQSTM1)) increases act(p(HGNC:VCP)) |
| pubmed:22908190 | path(CONSO:"granulovacuolar degeneration") association a(MESH:Ubiquitin) |
| pubmed:22908190 | path(CONSO:"granulovacuolar degeneration") association a(MESH:Ubiquitin) |
| pubmed:11943212 | path(CONSO:"granulovacuolar degeneration") association complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)), p(HGNC:MARK4, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:11943212 | path(CONSO:"granulovacuolar degeneration") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | a(MESH:"Neuropil Threads") association a(MESH:Ubiquitin) |
| pubmed:26195256 | a(MESH:"Neuropil Threads") association p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:22817713 | a(MESH:"Neuropil Threads") association path(MESH:"Alzheimer Disease") |
| pubmed:23088643 | a(MESH:"Neuropil Threads") association p(CONSO:"Tau epitope, AT8") |
| pubmed:22908190 | bp(GO:"histone H2B ubiquitination") association bp(MESH:"Transcription, Genetic") |
| pubmed:22908190 | bp(MESH:"Transcription, Genetic") association bp(GO:"histone H2B ubiquitination") |
| pubmed:22908190 | p(CONSO:"Tau isoform F (441 aa)", pmod(go:0016567 ! "protein ubiquitination", Lys, 254)) association a(CONSO:"paired helical filaments") |
| pubmed:22908190 | p(CONSO:"Tau isoform F (441 aa)", pmod(go:0016567 ! "protein ubiquitination", Lys, 257)) association a(CONSO:"paired helical filaments") |
| pubmed:22908190 | p(CONSO:"Tau isoform F (441 aa)", pmod(go:0016567 ! "protein ubiquitination", Lys, 311)) association a(CONSO:"paired helical filaments") |
| pubmed:22908190 | p(CONSO:"Tau isoform F (441 aa)", pmod(go:0016567 ! "protein ubiquitination", Lys, 317)) association a(CONSO:"paired helical filaments") |
| pubmed:22908190 | p(CONSO:"Tau isoform F (441 aa)", pmod(go:0070936 ! "protein K48-linked ubiquitination")) association a(CONSO:"paired helical filaments") |
| pubmed:22908190 | p(CONSO:"Tau isoform F (441 aa)", pmod(go:0070936 ! "protein K48-linked ubiquitination")) association a(CONSO:"paired helical filaments") |
| pubmed:22908190 | p(CONSO:"Tau isoform F (441 aa)", pmod(go:0000209 ! "protein polyubiquitination", Lys, 6)) association a(CONSO:"paired helical filaments") |
| pubmed:22908190 | p(CONSO:"Tau isoform F (441 aa)", pmod(go:0000209 ! "protein polyubiquitination", Lys, 11)) association a(CONSO:"paired helical filaments") |
| pubmed:22908190 | a(GO:"Pick body") association p(HGNC:MAPT) |
| pubmed:27574109 | a(GO:"Pick body") association p(HGNC:MAPT) |
| pubmed:22908190 | a(GO:"Pick body") association a(MESH:Ubiquitin) |
| pubmed:27574109 | a(GO:"Pick body") association a(CONSO:"Tau oligomers") |
| pubmed:27574109 | a(GO:"Pick body") association p(CONSO:"phosphatase-activating domain") |
| pubmed:22908190 | complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA2), p(HGNC:UBA3)) increases p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:24457024 | complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA2), p(HGNC:UBA3)) increases bp(GO:"protein ubiquitination") |
| pubmed:22908190 | p(HGNC:UBE4A) increases bp(GO:"protein polyubiquitination") |
| pubmed:22908190 | complex(a(GO:"proteasome regulatory particle"), p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"))) increases tloc(a(MESH:Proteins), fromLoc(GO:"proteasome regulatory particle"), toLoc(CONSO:"20 S Proteasome")) |
| pubmed:22908190 | complex(a(GO:"proteasome regulatory particle"), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) negativeCorrelation act(complex(GO:"proteasome complex")) |
| pubmed:22908190 | complex(a(CONSO:"paired helical filaments"), a(GO:"proteasome regulatory particle")) decreases act(complex(GO:"proteasome complex")) |
| pubmed:22908190 | p(CONSO:"Tau aggregates", pmod(CONSO:hyperphosphorylation)) increases p(CONSO:"Tau aggregates", pmod(CONSO:hyperphosphorylation), pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:22908190 | p(CONSO:"UBB+1") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23528736 | p(CONSO:"UBB+1") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | p(CONSO:"UBB+1") positiveCorrelation path(MESH:"Niemann-Pick Diseases") |
| pubmed:22908190 | p(CONSO:"UBB+1") positiveCorrelation path(MESH:"Huntington Disease") |
| pubmed:22908190 | p(CONSO:"UBB+1") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:22908190 | p(CONSO:"UBB+1") decreases bp(GO:memory) |
| pubmed:23528736 | p(CONSO:"UBB+1") association a(MESH:"Neurofibrillary Tangles") |
| pubmed:22908190 | p(CONSO:"UBB+1", pmod(go:0000209 ! "protein polyubiquitination")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:22908190 | p(CONSO:"UBB+1", pmod(go:0000209 ! "protein polyubiquitination")) decreases deg(p(CONSO:"UBB+1", pmod(go:0000209 ! "protein polyubiquitination"))) |
| pubmed:22908190 | p(CONSO:"UBB+1", pmod(go:0000209 ! "protein polyubiquitination")) increases path(CONSO:neurotoxicity) |
| pubmed:22908190 | p(HGNC:UCHL1, pmod(GO:"protein oxidation")) negativeCorrelation a(GO:"neurofibrillary tangle") |
| pubmed:22908190 | p(HGNC:UBQLN1, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | deg(p(FPLX:PKA, pmod(go:0016567 ! "protein ubiquitination"))) increases act(p(FPLX:PKA)) |
| pubmed:22908190 | a(CONSO:"AβOs") decreases act(a(GO:synapse)) |
| pubmed:22908190 | a(CONSO:"AβOs") decreases bp(GO:"long-term synaptic potentiation") |
| pubmed:22908190 | a(CONSO:"AβOs") decreases bp(GO:learning) |
| pubmed:22908190 | a(CONSO:"AβOs") decreases bp(GO:memory) |
| pubmed:22908190 | a(CONSO:"AβOs") increases bp(GO:"long-term synaptic depression") |
| pubmed:22908190 | a(CONSO:"AβOs") decreases bp(GO:"L-glutamate import") |
| pubmed:22908190 | a(CONSO:"AβOs") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:22908190 | a(CONSO:"AβOs") increases deg(a(MESH:Neurites)) |
| pubmed:22908190 | a(CONSO:"AβOs") decreases act(complex(GO:"proteasome complex")) |
| pubmed:28528849 | a(CONSO:"AβOs") decreases a(MESH:"Dendritic Spines") |
| pubmed:22908190 | complex(p(HGNC:HSPA8), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)), p(HGNC:STUB1)) increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) |
| pubmed:22908190 | complex(GO:"clathrin complex") increases bp(GO:"plasma membrane invagination") |
| pubmed:22908190 | a(GO:caveola) increases bp(GO:"plasma membrane invagination") |
| pubmed:22908190 | bp(GO:"bulk synaptic vesicle endocytosis") increases bp(GO:"plasma membrane invagination") |
| pubmed:29590627 | bp(GO:"bulk synaptic vesicle endocytosis") negativeCorrelation a(CHEBI:"cytochalasin D") |
| pubmed:29590627 | bp(GO:"bulk synaptic vesicle endocytosis") positiveCorrelation bp(GO:"actin filament polymerization") |
| pubmed:22908190 | p(HGNC:RAB7A) increases a(GO:endosome) |
| pubmed:22908190 | p(HGNC:RAB7A) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | p(HGNC:RAB7A) increases complex(a(GO:"early endosome"), a(GO:"late endosome")) |
| pubmed:22908190 | p(HGNC:RAB7A) association bp(GO:"regulation of endosome size") |
| pubmed:18930136 | p(HGNC:RAB7A) increases bp(GO:"autophagosome-lysosome fusion") |
| pubmed:29238289 | p(HGNC:RAB7A) association tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27181519 | p(HGNC:RAB7A) association g(HGNC:C9orf72) |
| pubmed:22908190 | act(a(GO:endosome)) increases bp(GO:"nerve growth factor signaling pathway") |
| pubmed:22908190 | act(a(GO:endosome)) decreases path(CONSO:Neurodegeneration) |
| pubmed:22908190 | complex(GO:"ESCRT complex") regulates tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:"multivesicular body")) |
| pubmed:22908190 | p(HGNC:M6PR) increases tloc(a(MESH:Cathepsins), fromLoc(GO:"trans-Golgi network"), toLoc(GO:"multivesicular body")) |
| pubmed:22908190 | a(MESH:Cathepsins) regulates deg(a(CHEBI:amyloid-beta)) |
| pubmed:22908190 | tloc(a(MESH:Cathepsins), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases bp(GO:"apoptotic process") |
| pubmed:22908190 | p(HGNC:IGF2R) increases tloc(a(MESH:Cathepsins), fromLoc(GO:"trans-Golgi network"), toLoc(GO:"multivesicular body")) |
| pubmed:22908190 | complex(a(GO:"late endosome"), a(GO:autophagosome), a(GO:lysosome)) increases deg(a(MESH:Proteins)) |
| pubmed:29024336 | a(GO:"late endosome") increases deg(p(MGI:Mapt)) |
| pubmed:29024336 | a(GO:"late endosome") decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) |
| pubmed:29024336 | a(GO:"late endosome") decreases deg(p(MGI:Mapt, var("p.Ala152Thr"))) |
| pubmed:29590627 | a(GO:"late endosome") association p(HGNC:MAPT, var("p.Pro301Ser")) |
| pubmed:29590627 | a(GO:"late endosome") association a(CONSO:"Tau aggregates") |
| pubmed:22908190 | complex(a(GO:"early endosome"), a(GO:autophagosome)) increases a(GO:amphisome) |
| pubmed:29590627 | a(GO:"early endosome") association p(HGNC:MAPT, var("p.Pro301Ser")) |
| pubmed:29590627 | a(GO:"early endosome") association a(CONSO:"Tau aggregates") |
| pubmed:18930136 | a(GO:amphisome) increases complex(a(GO:amphisome), a(GO:lysosome)) |
| pubmed:22908190 | complex(a(GO:"late endosome"), a(GO:autophagosome)) increases a(GO:amphisome) |
| pubmed:22908190 | complex(a(GO:"multivesicular body"), a(GO:autophagosome)) increases a(GO:amphisome) |
| pubmed:22908190 | bp(GO:"regulation of endosome size") association path(MESH:"Neurodegenerative Diseases") |
| pubmed:22908190 | bp(GO:"regulation of endosome size") association a(CONSO:"Braak_Stage II") |
| pubmed:22908190 | bp(GO:"regulation of endosome size") negativeCorrelation path(MESH:"Down Syndrome") |
| pubmed:22908190 | bp(GO:"regulation of endosome size") association p(HGNC:RAB7A) |
| pubmed:22908190 | bp(GO:"regulation of endosome size") association p(HGNC:RAB5A) |
| pubmed:22908190 | bp(GO:"regulation of endosome size") association p(HGNC:RAB4A) |
| pubmed:22908190 | a(CONSO:"Braak_Stage II") association bp(GO:"regulation of endosome size") |
| pubmed:27574109 | a(CONSO:"Braak_Stage II") association a(CONSO:"Tau oligomers") |
| pubmed:27574109 | a(CONSO:"Braak_Stage II") association p(CONSO:"phosphatase-activating domain") |
| pubmed:27574109 | a(CONSO:"Braak_Stage II") association p(HGNC:MAPT) |
| pubmed:28176663 | a(CONSO:"Braak_Stage II") positiveCorrelation act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:22908190 | p(HGNC:RAB5A) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | p(HGNC:RAB5A) increases complex(a(GO:"early endosome"), a(GO:"late endosome")) |
| pubmed:22908190 | p(HGNC:RAB5A) association bp(GO:"regulation of endosome size") |
| pubmed:22908190 | act(p(HGNC:RAB5A)) positiveCorrelation a(MESH:Proteins) |
| pubmed:22908190 | act(p(HGNC:RAB5A)) positiveCorrelation a(CHEBI:lipid) |
| pubmed:22908190 | act(p(HGNC:RAB5A)) negativeCorrelation bp(GO:"lysosomal protein catabolic process") |
| pubmed:22908190 | act(p(HGNC:RAB5A)) positiveCorrelation bp(GO:"neuron death") |
| pubmed:22908190 | act(p(HGNC:RAB5A)) increases bp(GO:endocytosis) |
| pubmed:22908190 | act(p(HGNC:RAB5A)) increases bp(GO:endocytosis) |
| pubmed:22908190 | act(p(HGNC:RAB5A)) decreases bp(GO:endocytosis) |
| pubmed:22908190 | act(p(HGNC:RAB5A)) increases a(CHEBI:amyloid-beta) |
| pubmed:22908190 | act(p(HGNC:RAB5A)) negativeCorrelation bp(GO:"long-term synaptic potentiation") |
| pubmed:22908190 | act(p(HGNC:RAB5A)) negativeCorrelation bp(GO:"long-term synaptic depression") |
| pubmed:30116051 | act(p(HGNC:RAB5A)) decreases bp(HP:Neurodegeneration) |
| pubmed:27607061 | act(p(HGNC:RAB5A)) negativeCorrelation tloc(p(HGNC:GRIK2), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) |
| pubmed:27607061 | act(p(HGNC:RAB5A)) partOf bp(GO:"clathrin-dependent endocytosis") |
| pubmed:27181519 | p(HGNC:RAB5A) association g(HGNC:C9orf72) |
| pubmed:22908190 | p(HGNC:RAB4A) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22908190 | p(HGNC:RAB4A) increases complex(a(GO:"early endosome"), a(GO:"late endosome")) |
| pubmed:22908190 | p(HGNC:RAB4A) association bp(GO:"regulation of endosome size") |
| pubmed:22908190 | bp(GO:"pH reduction") increases bp(GO:"lysosomal protein catabolic process") |
| pubmed:22908190 | p(HGNC:ATP6V0A1, pmod(go:0006487 ! "protein N-linked glycosylation")) increases bp(GO:"pH reduction") |
| pubmed:22908190 | complex(a(GO:endosome), p(HGNC:APP, var("?")), p(HGNC:NAE1, var("?"))) increases act(p(HGNC:RAB5A)) |
| pubmed:22908190 | a(CHEBI:"low-density lipoprotein cholesterol") positiveCorrelation p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") |
| pubmed:22908190 | a(CHEBI:"low-density lipoprotein cholesterol") positiveCorrelation p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") |
| pubmed:22908190 | a(CHEBI:"low-density lipoprotein cholesterol") positiveCorrelation tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) |
| pubmed:22908190 | bp(GO:"response to acidic pH") increases a(CONSO:"amyloid-beta oligomers") |
| pubmed:22908190 | p(HGNC:RIN1) increases act(p(HGNC:RAB5A)) |
| pubmed:22908190 | p(HGNC:RIN1) decreases bp(GO:"long-term synaptic potentiation") |
| pubmed:22908190 | p(HGNC:RIN1) decreases bp(GO:"fear response") |
| pubmed:22908190 | p(HGNC:RIN1) decreases bp(GO:memory) |
| pubmed:22908190 | p(HGNC:RIN1) decreases a(MESH:"Receptors, AMPA") |
| pubmed:22908190 | tloc(a(MESH:Hydrolases), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases path(MESH:Necrosis) |
| pubmed:22908190 | p(HGNC:CST3) decreases act(a(GO:synapse)) |
| pubmed:24563850 | a(MESH:"Heat-Shock Proteins") regulates bp(GO:"response to oxidative stress") |
| pubmed:21882945 | a(MESH:"Heat-Shock Proteins") increases bp(GO:"proteasomal protein catabolic process") |
| pubmed:21882945 | a(MESH:"Heat-Shock Proteins") increases bp(GO:autophagy) |
| pubmed:23746257 | act(p(HGNCGENEFAMILY:Chaperonins)) association bp(GO:"'de novo' protein folding") |
| pubmed:23746257 | act(p(HGNCGENEFAMILY:Chaperonins)) association bp(GO:"protein refolding") |
| pubmed:23746257 | bp(GO:"protein refolding") association act(p(HGNCGENEFAMILY:Chaperonins)) |
| pubmed:23746257 | bp(GO:"protein refolding") association act(p(FPLX:HSPA)) |
| pubmed:23746257 | bp(GO:"protein refolding") association act(p(FPLX:HSPA)) |
| pubmed:23746257 | bp(GO:"protein refolding") association act(p(FPLX:HSP90)) |
| pubmed:23746257 | complex(p(FPLX:"CCT_complex"), p(FPLX:HSPA)) increases bp(GO:"'de novo' protein folding") |
| pubmed:23746257 | bp(GO:"steroid hormone mediated signaling pathway") association p(FPLX:HSP90) |
| pubmed:23746257 | bp(GO:"intracellular protein transmembrane transport") association act(p(FPLX:HSPA)) |
| pubmed:23746257 | p(FPLX:RAPGEF) regulates act(p(FPLX:HSPA)) |
| pubmed:23746257 | composite(p(FPLX:HSPA), p(HGNC:HSPH1), p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins")) decreases a(MESH:"Protein Aggregates") |
| pubmed:21882945 | p(HGNC:HSPH1) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23746257 | complex(p(HGNC:HSPD1), p(HGNC:HSPE1)) increases bp(GO:"protein refolding") |
| pubmed:23746257 | complex(a(CHEBI:ATP), p(HGNC:HSPD1)) increases complex(p(HGNC:HSPD1), p(HGNC:HSPE1)) |
| pubmed:23746257 | a(PUBCHEM:5288382) decreases complex(a(CHEBI:ATP), p(FPLX:HSP90)) |
| pubmed:23746257 | complex(a(CHEBI:ATP), p(FPLX:HSP90)) regulates act(p(FPLX:HSP90)) |
| pubmed:29311797 | complex(a(CHEBI:ATP), p(FPLX:HSP90)) increases bp(MESH:Proteolysis) |
| pubmed:29311797 | complex(a(CHEBI:ATP), p(FPLX:HSP90)) increases bp(GO:"protein folding") |
| pubmed:29311797 | complex(a(CHEBI:ATP), p(FPLX:HSP90)) decreases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:29311797 | complex(a(CHEBI:ATP), p(FPLX:HSP90)) increases bp(GO:"protein modification process") |
| pubmed:23746257 | a(PUBCHEM:6323491) decreases complex(a(CHEBI:ATP), p(FPLX:HSP90)) |
| pubmed:23746257 | bp(GO:"ATP metabolic process") increases act(p(FPLX:HSP90)) |
| pubmed:25784053 | bp(GO:"ATP metabolic process") increases act(p(FPLX:HSP90)) |
| pubmed:29311797 | bp(GO:"ATP metabolic process") increases act(p(FPLX:HSP90)) |
| pubmed:25784053 | bp(GO:"ATP metabolic process") increases act(p(FPLX:HSPA)) |
| pubmed:23746257 | p(HGNC:AHSA1) increases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pubmed:21882945 | p(HGNC:AHSA1) regulates act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pubmed:29311797 | p(HGNC:AHSA1) increases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pubmed:21882945 | p(HGNC:AHSA1) increases rxn(reactants(a(CHEBI:ATP)), products(a(CHEBI:"phosphate(3-)"), a(CHEBI:ADP))) |
| pubmed:21882945 | p(HGNC:AHSA1) increases complex(a(CHEBI:polypeptide), p(HGNC:STUB1)) |
| pubmed:29311797 | p(HGNC:AHSA1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29311797 | p(HGNC:AHSA1) increases a(CONSO:"Tau aggregates") |
| pubmed:29311797 | p(HGNC:AHSA1) association path(MESH:"Cystic Fibrosis") |
| pubmed:23746257 | bp(GO:"behavioral response to starvation") association bp(CONSO:Proteostasis) |
| pubmed:23746257 | composite(p(FPLX:HSP90), p(FPLX:HSPA), p(HGNC:BAG1), p(HGNC:BAG3), p(HGNC:STUB1)) increases bp(GO:"protein ubiquitination") |
| pubmed:23746257 | p(HGNC:BAG1) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:25036637 | p(HGNC:BAG1) increases complex(p(HGNC:BAG1), p(HGNC:LTN1)) |
| pubmed:25036637 | p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMA5)) |
| pubmed:25036637 | p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMC4)) |
| pubmed:25036637 | p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMD2)) |
| pubmed:21882945 | p(HGNC:BAG1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21882945 | p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:MAPT)) |
| pubmed:21882945 | p(HGNC:BAG1) decreases deg(p(HGNC:MAPT)) |
| pubmed:17954934 | p(HGNC:BAG1) increases p(HGNC:MAPT) |
| pubmed:17954934 | p(HGNC:BAG1) decreases deg(p(HGNC:MAPT)) |
| pubmed:17954934 | p(HGNC:BAG1) positiveCorrelation p(HGNC:MAPT) |
| pubmed:17954934 | p(HGNC:BAG1) decreases deg(p(HGNC:MAPT)) |
| pubmed:17954934 | p(HGNC:BAG1) isA complex(p(HGNC:BAG1), p(HGNC:HSPA8), p(HGNC:MAPT)) |
| pubmed:17954934 | p(HGNC:BAG1) association act(a(MESH:Neurons)) |
| pubmed:17954934 | p(HGNC:BAG1) negativeCorrelation act(complex(GO:"proteasome complex")) |
| pubmed:17954934 | p(HGNC:BAG1) negativeCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:17954934 | p(HGNC:BAG1) causesNoChange p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:23746257 | p(FPLX:EIF2B, pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(FPLX:EIF2B)) |
| pubmed:23746257 | a(CHEBI:geldanamycin) increases act(p(HGNC:HSF1)) |
| pubmed:25784053 | a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) |
| pubmed:30116051 | a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) |
| pubmed:21882945 | a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) |
| pubmed:21882945 | a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) |
| pubmed:30116051 | a(CHEBI:geldanamycin) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:30116051 | a(CHEBI:geldanamycin) decreases a(CONSO:"alpha-synuclein oligomers") |
| pubmed:24027553 | a(CHEBI:geldanamycin) increases act(p(HGNCGENEFAMILY:Proteasome)) |
| pubmed:21882945 | a(CHEBI:geldanamycin) decreases complex(p(FPLX:HSP90), p(HGNC:PTGES3)) |
| pubmed:23746257 | composite(p(FPLX:"CCT_complex"), p(FPLX:HSPA)) decreases a(MESH:"Protein Aggregates") |
| pubmed:23746257 | composite(p(FPLX:"CCT_complex"), p(FPLX:HSPA)) decreases a(CONSO:"huntingtin aggregates") |
| pubmed:24457024 | complex(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) |
| pubmed:24457024 | complex(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) |
| pubmed:24457024 | p(HGNC:UBE2K) increases complex(a(MESH:Ubiquitin), p(HGNC:UBE2K)) |
| pubmed:24457024 | p(HGNC:UBE2S) increases complex(a(MESH:Ubiquitin), p(HGNC:UBE2S)) |
| pubmed:24457024 | path(MESH:"RING Finger Domains") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) |
| pubmed:24457024 | p(INTERPRO:"U box domain") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) |
| pubmed:24457024 | complex(a(MESH:Ubiquitin), p(MESH:Proteins, pmod(CONSO:misfolding))) increases deg(p(MESH:Proteins, pmod(CONSO:misfolding))) |
| pubmed:24457024 | p(HGNC:BAG6) increases complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(CONSO:misfolding))) |
| pubmed:24457024 | complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(CONSO:misfolding))) association bp(GO:"ERAD pathway") |
| pubmed:24457024 | complex(p(HGNC:BAG6), p(HGNC:UBA3)) increases deg(p(MESH:Proteins, pmod(CONSO:misfolding))) |
| pubmed:24457024 | complex(p(HGNC:BAG6), p(HGNC:UBA3)) increases bp(GO:"protein ubiquitination") |
| pubmed:24457024 | complex(p(HGNC:BAG6), p(HGNC:UBA3)) decreases bp(CONSO:"protein aggregation") |
| pubmed:24457024 | complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) increases deg(p(MESH:Proteins, pmod(CONSO:misfolding))) |
| pubmed:24457024 | complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) decreases bp(CONSO:"protein aggregation") |
| pubmed:24457024 | complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) increases bp(GO:"protein ubiquitination") |
| pubmed:24457024 | a(MESH:"Deubiquitinating Enzymes") decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) |
| pubmed:24457024 | a(MESH:"Deubiquitinating Enzymes") increases p(MESH:Ubiquitin, frag("?")) |
| pubmed:26091809 | p(MESH:Ubiquitin, loc(GO:"inclusion body")) increases p(HGNC:TARDBP) |
| pubmed:24457024 | complex(a(GO:"proteasome complex"), p(HGNC:UCHL5)) increases bp(GO:"protein catabolic process") |
| pubmed:24457024 | complex(a(GO:"proteasome complex"), p(HGNC:USP14)) increases bp(GO:"protein catabolic process") |
| pubmed:24457024 | complex(a(GO:"proteasome complex"), p(HGNC:USP14)) decreases bp(GO:"protein catabolic process") |
| pubmed:24457024 | act(p(HGNC:USP6)) decreases path(MESH:Aneuploidy) |
| pubmed:24457024 | p(HGNC:ADRM1) increases complex(a(GO:"proteasome complex"), p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"))) |
| pubmed:25036637 | p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMA5)) |
| pubmed:25036637 | p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMC1)) |
| pubmed:25036637 | p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMD1)) |
| pubmed:25036637 | p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMD4)) |
| pubmed:24457024 | p(HGNC:PSMD14) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) |
| pubmed:24457024 | p(HGNC:PSMD14) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) |
| pubmed:24457024 | act(p(HGNC:PSMD14)) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(CONSO:"20 S Proteasome")) |
| pubmed:24457024 | complex(a(GO:"proteasome complex"), a(MESH:Proteins)) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(CONSO:"20 S Proteasome")) |
| pubmed:25784053 | bp(MESH:"Protein Biosynthesis") association bp(CONSO:Proteostasis) |
| pubmed:25784053 | bp(MESH:Proteolysis) association bp(CONSO:Proteostasis) |
| pubmed:29311797 | bp(MESH:Proteolysis) association a(MESH:"Molecular Chaperones") |
| pubmed:25784053 | bp(MESH:"Growth and Development") regulates bp(CONSO:Proteostasis) |
| pubmed:25784053 | complex(p(FPLX:HSPA), p(HGNC:DNAJB1), p(HGNC:HSPH1)) decreases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:25784053 | p(HGNC:DNAJB1) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pubmed:25036637 | p(HGNC:DNAJB1) increases complex(p(HGNC:DNAJB1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pubmed:25784053 | a(MESH:"Cellular Structures") association p(FPLX:"CCT_complex") |
| pubmed:25784053 | bp(GO:"response to misfolded protein") increases act(p(HGNC:HSF1)) |
| pubmed:25784053 | bp(GO:"response to misfolded protein") increases act(p(HGNC:ERN1), ma(go:0016301 ! "kinase activity")) |
| pubmed:25784053 | p(HGNC:HSF1, pmod(go:0006473 ! "protein acetylation")) decreases act(p(HGNC:HSF1)) |
| pubmed:25784053 | complex(a(MESH:"Molecular Chaperones"), p(HGNC:HSF1)) decreases act(p(HGNC:HSF1)) |
| pubmed:25784053 | p(HGNC:PRSS1) decreases p(HGNC:ATF6) |
| pubmed:25784053 | p(HGNC:PRSS1) increases p(CONSO:"N-terminal fragment of ATF6") |
| pubmed:25784053 | p(HGNC:PRSS2) decreases p(HGNC:ATF6) |
| pubmed:25784053 | p(HGNC:PRSS2) increases p(CONSO:"N-terminal fragment of ATF6") |
| pubmed:25784053 | tloc(p(CONSO:"N-terminal fragment of ATF6"), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) increases act(p(CONSO:"N-terminal fragment of ATF6"), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:25784053 | act(p(CONSO:"N-terminal fragment of ATF6"), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases bp(GO:"response to misfolded protein") |
| pubmed:25784053 | p(HGNC:ATXN1, var("?")) causesNoChange p(FPLX:HSPA) |
| pubmed:25784053 | p(HGNC:SOD1, var("p.Gly576Arg")) decreases a(CHEBI:N-retinylidene-N-retinylethanolamine) |
| pubmed:25784053 | p(HGNC:SOD1, var("p.Gly576Arg")) decreases p(HGNC:MAP1LC3A) |
| pubmed:25784053 | p(HGNC:SOD1, var("p.Gly576Arg")) decreases p(HGNC:SQSTM1) |
| pubmed:25784053 | p(HGNC:SOD1, var("p.Gly576Arg")) increases bp(GO:autophagy) |
| pubmed:25784053 | a(CHEBI:radicicol) decreases act(p(FPLX:HSP90)) |
| pubmed:21882945 | a(CHEBI:radicicol) directlyDecreases act(p(FPLX:HSP90)) |
| pubmed:21882945 | a(CHEBI:radicicol) directlyIncreases complex(a(CHEBI:radicicol), p(INTERPRO:"Heat shock protein Hsp90, N-terminal")) |
| pubmed:21882945 | a(CHEBI:radicicol) decreases path(MESH:Neoplasms) |
| pubmed:25784053 | a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) |
| pubmed:30116051 | a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) |
| pubmed:21882945 | a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) |
| pubmed:29311797 | a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pubmed:21367866 | a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) |
| pubmed:30116051 | a(CHEBI:tanespimycin) decreases a(CHEBI:amyloid-beta) |
| pubmed:30116051 | a(CHEBI:tanespimycin) increases bp(GO:memory) |
| pubmed:30116051 | a(CHEBI:tanespimycin) decreases p(HGNC:MAPT) |
| pubmed:30116051 | a(CHEBI:tanespimycin) decreases a(CONSO:"alpha-synuclein oligomers") |
| pubmed:21882945 | a(CHEBI:tanespimycin) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:21882945 | a(CHEBI:tanespimycin) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:29311797 | a(CHEBI:tanespimycin) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25784053 | a(PUBCHEM:377503130) increases act(p(HGNC:HSF1)) |
| pubmed:25784053 | a(PUBCHEM:377503130) decreases act(p(FPLX:"CCT_complex")) |
| pubmed:25784053 | a(PUBCHEM:10521421) decreases act(p(FPLX:AKT)) |
| pubmed:25784053 | a(PUBCHEM:10521421) increases bp(GO:autophagy) |
| pubmed:25784053 | a(CHEBI:fluphenazine) increases bp(GO:autophagy) |
| pubmed:25784053 | a(CHEBI:fluphenazine) decreases p(HGNC:TARDBP) |
| pubmed:25784053 | a(CHEBI:methotrimeprazine) increases bp(GO:autophagy) |
| pubmed:25784053 | a(CHEBI:methotrimeprazine) decreases p(HGNC:TARDBP) |
| pubmed:25784053 | a(PUBCHEM:799645) increases bp(GO:autophagy) |
| pubmed:25784053 | a(PUBCHEM:799645) decreases p(HGNC:SNCA, var("p.Ala53Thr")) |
| pubmed:25784053 | a(PUBCHEM:799645) decreases a(CONSO:"huntingtin aggregates") |
| pubmed:25784053 | a(PUBCHEM:877863) increases bp(GO:autophagy) |
| pubmed:25784053 | a(PUBCHEM:877863) decreases p(HGNC:SNCA, var("p.Ala53Thr")) |
| pubmed:25784053 | a(PUBCHEM:877863) decreases a(CONSO:"huntingtin aggregates") |
| pubmed:25784053 | a(PUBCHEM:1560402) increases bp(GO:autophagy) |
| pubmed:25784053 | a(PUBCHEM:1560402) decreases p(HGNC:SNCA, var("p.Ala53Thr")) |
| pubmed:25784053 | a(PUBCHEM:1560402) decreases a(CONSO:"huntingtin aggregates") |
| pubmed:25784053 | composite(a(CHEBI:sirolimus), a(PUBCHEM:799645)) decreases p(HGNC:SNCA, var("p.Ala53Thr")) |
| pubmed:25784053 | composite(a(CHEBI:sirolimus), a(PUBCHEM:877863)) decreases p(HGNC:SNCA, var("p.Ala53Thr")) |
| pubmed:25784053 | composite(a(CHEBI:sirolimus), a(PUBCHEM:1560402)) decreases p(HGNC:SNCA, var("p.Ala53Thr")) |
| pubmed:25784053 | a(PUBCHEM:675434) decreases p(HGNC:MAPT) |
| pubmed:23528736 | a(PUBCHEM:675434) increases deg(p(HGNC:MAPT)) |
| pubmed:25784053 | a(PUBCHEM:675434) decreases p(HGNC:TARDBP) |
| pubmed:25784053 | a(PUBCHEM:675434) decreases p(HGNC:ATXN3) |
| pubmed:25784053 | a(PUBCHEM:675434) decreases act(p(HGNC:USP14)) |
| pubmed:23528736 | a(PUBCHEM:675434) decreases act(p(HGNC:USP14)) |
| pubmed:25784053 | a(PUBCHEM:675434) causesNoChange p(FPLX:Proteasome) |
| pubmed:23528736 | a(PUBCHEM:675434) increases act(p(FPLX:Proteasome)) |
| pubmed:18930136 | deg(a(CHEBI:oligopeptide)) increases a(CHEBI:"amino acid") |
| pubmed:26702100 | a(CHEBI:"amino acid") regulates act(p(HGNCGENEFAMILY:"MTOR complex 1")) |
| pubmed:26702100 | a(CHEBI:"amino acid") increases p(HGNC:MTOR) |
| pubmed:26702100 | a(CHEBI:"amino acid") increases p(HGNC:MTOR) |
| pubmed:26702100 | a(CHEBI:"amino acid") increases p(HGNC:RPS6KB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 389)) |
| pubmed:26702100 | a(CHEBI:"amino acid") increases act(p(HGNC:RRAGA)) |
| pubmed:18930136 | bp(GO:"antigen processing and presentation") association bp(GO:autophagy) |
| pubmed:18930136 | bp(GO:"autophagy of nucleus") isA bp(GO:macroautophagy) |
| pubmed:18930136 | bp(GO:pexophagy) isA bp(GO:macroautophagy) |
| pubmed:18930136 | bp(GO:reticulophagy) isA bp(GO:macroautophagy) |
| pubmed:18930136 | bp(GO:xenophagy) isA bp(GO:macroautophagy) |
| pubmed:18930136 | bp(GO:ribophagy) isA bp(GO:macroautophagy) |
| pubmed:18930136 | bp(GO:aggrephagy) isA bp(GO:macroautophagy) |
| pubmed:18930136 | complex(a(MESH:Proteins), p(HGNC:HSPA8)) increases bp(GO:"chaperone-mediated autophagy") |
| pubmed:18930136 | complex(a(MESH:Proteins), p(HGNC:HSPA8)) increases complex(a(MESH:Proteins), p(HGNC:HSPA8), p(HGNC:LAMP2)) |
| pubmed:18930136 | composite(p(HGNC:ATG10), p(HGNC:ATG7)) increases complex(p(HGNC:ATG12), p(HGNC:ATG5)) |
| pubmed:18930136 | composite(p(HGNC:ATG10), p(HGNC:ATG7)) increases a(GO:phagophore) |
| pubmed:18930136 | complex(p(HGNC:ATG12), p(HGNC:ATG5)) increases complex(p(HGNC:ATG12), p(HGNC:ATG16L1), p(HGNC:ATG5)) |
| pubmed:18930136 | complex(p(HGNC:ATG12), p(HGNC:ATG5)) increases p(HGNC:GABARAPL2, pmod(GO:"protein lipidation")) |
| pubmed:18930136 | complex(p(HGNC:ATG12), p(HGNC:ATG16L1), p(HGNC:ATG5)) increases a(GO:phagophore) |
| pubmed:18930136 | p(HGNC:ATG4A) increases p(HGNC:GABARAPL2, frag("?")) |
| pubmed:18930136 | p(HGNC:ATG4A) increases complex(p(HGNC:ATG4A), p(HGNC:ATG7)) |
| pubmed:18930136 | composite(p(HGNC:ATG12), p(HGNC:ATG3), p(HGNC:ATG5)) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:GABARAPL2, frag("?"))) |
| pubmed:18930136 | complex(a(GO:"multivesicular body"), a(GO:autophagosome), a(GO:endosome)) increases a(GO:amphisome) |
| pubmed:18930136 | complex(a(GO:amphisome), a(GO:lysosome)) increases a(GO:autolysosome) |
| pubmed:18930136 | p(HGNC:GABARAP) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:GABARAP)) |
| pubmed:18930136 | complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) increases complex(a(CHEBI:phosphatidylethanolamine), a(GO:phagophore), p(HGNC:MAP1LC3B)) |
| pubmed:18930136 | complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) association a(GO:autophagosome) |
| pubmed:18930136 | path(MESH:"Creutzfeldt-Jakob Syndrome") positiveCorrelation a(GO:autophagosome) |
| pubmed:18930136 | path(MESH:"Neuronal Ceroid-Lipofuscinoses") negativeCorrelation act(a(GO:lysosome)) |
| pubmed:18930136 | p(HGNC:CLN3, var("?")) increases path(MESH:"Neuronal Ceroid-Lipofuscinoses") |
| pubmed:18930136 | p(HGNC:ATP13A2, var("?")) increases bp(GO:"proteasomal protein catabolic process") |
| pubmed:18930136 | p(HGNC:ATP13A2, var("?")) increases path(CONSO:Neurodegeneration) |
| pubmed:18930136 | p(HGNC:RAB7A, var("?")) decreases bp(GO:"autophagosome-lysosome fusion") |
| pubmed:18930136 | p(HGNC:DCTN1, var("?")) positiveCorrelation a(GO:autophagosome) |
| pubmed:8391280 | p(HGNC:DCTN1) isA complex(p(HGNC:DCTN1), p(HGNC:MAPT)) |
| pubmed:8391280 | p(HGNC:DCTN1) association p(INTERPRO:"MAP2/Tau projection") |
| pubmed:8391280 | p(HGNC:DCTN1) isA p(INTERPRO:"Dynein associated protein") |
| pubmed:26702100 | p(HGNC:DCTN1) increases bp(GO:"autophagosome-lysosome fusion") |
| pubmed:26702100 | p(HGNC:DCTN1) increases bp(GO:"autophagosome-lysosome fusion") |
| pubmed:18930136 | bp(GO:"protein monoubiquitination") increases bp(GO:endocytosis) |
| pubmed:18930136 | a(GO:aggresome) negativeCorrelation bp(GO:"cell death") |
| pubmed:18930136 | composite(a(CHEBI:lactacystin), a(CHEBI:sirolimus)) decreases bp(GO:"apoptotic process") |
| pubmed:18930136 | composite(a(CHEBI:lactacystin), a(CHEBI:sirolimus)) decreases p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:18930136 | p(HGNC:WDFY3) regulates bp(GO:autophagy) |
| pubmed:18930136 | p(HGNC:WDFY3) regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:18930136 | p(HGNC:WDFY3) regulates a(GO:aggresome) |
| pubmed:18930136 | tloc(p(HGNC:WDFY3), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) increases bp(GO:"protein ubiquitination") |
| pubmed:18930136 | p(HGNC:WDFY3) increases bp(GO:"ubiquitin-dependent protein catabolic process") |
| pubmed:18930136 | bp(GO:"Hsp90 deacetylation") increases act(p(HGNC:HSF1)) |
| pubmed:18930136 | a(MESH:"Huntingtin Protein") association p(HGNC:SQSTM1) |
| pubmed:24563850 | act(p(HGNC:XDH)) increases a(CHEBI:radical) |
| pubmed:24563850 | act(p(HGNC:XDH)) increases a(CHEBI:"reactive oxygen species") |
| pubmed:24563850 | act(p(HGNCGENEFAMILY:"Cytochrome P450 family 1")) increases a(CHEBI:radical) |
| pubmed:24563850 | act(p(HGNCGENEFAMILY:"Cytochrome P450 family 1")) increases a(CHEBI:"reactive oxygen species") |
| pubmed:24563850 | act(a(MESH:Peroxisomes)) increases a(CHEBI:radical) |
| pubmed:24563850 | bp(GO:"response to radiation") increases a(CHEBI:radical) |
| pubmed:24563850 | a(MESH:"Air Pollution") increases a(CHEBI:radical) |
| pubmed:24563850 | bp(MESH:"Host-Pathogen Interactions") association a(CHEBI:radical) |
| pubmed:24563850 | bp(CONSO:"non-enzymatic protein modification") positiveCorrelation bp(GO:aging) |
| pubmed:24563850 | bp(CONSO:"non-enzymatic protein modification") increases bp(CONSO:misfolding) |
| pubmed:24563850 | p(HGNCGENEFAMILY:"Small heat shock proteins") decreases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:24563850 | bp(GO:"post-translational protein modification") regulates p(HGNCGENEFAMILY:"Small heat shock proteins") |
| pubmed:24563850 | bp(GO:"cellular response to heat") increases p(HGNC:HSPA1A, loc(MESH:"Extracellular Space")) |
| pubmed:24563850 | p(HGNC:CAT) increases rxn(reactants(a(CHEBI:"hydrogen peroxide")), products(a(CHEBI:dioxygen), a(CHEBI:water))) |
| pubmed:29626319 | tloc(a(CHEBI:water), fromLoc(GO:"extracellular region"), toLoc(MESH:"Cerebrospinal Fluid")) decreases a(CHEBI:amyloid-beta) |
| pubmed:24563850 | p(HGNC:GPX1) increases rxn(reactants(a(CHEBI:"hydrogen peroxide")), products(a(CHEBI:water))) |
| pubmed:24563850 | complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(HGNC:NQO1) |
| pubmed:24563850 | complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(HGNC:HMOX1) |
| pubmed:24563850 | complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(HGNC:GCLC) |
| pubmed:24563850 | complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(FPLX:GST) |
| pubmed:24563850 | bp(GO:"protein oxidation") association bp(GO:aging) |
| pubmed:24563850 | bp(GO:"protein oxidation") association path(MESH:"Cardiovascular Diseases") |
| pubmed:24563850 | bp(GO:"protein oxidation") association bp(HP:Neurodegeneration) |
| pubmed:24563850 | bp(GO:"protein oxidation") association path(MESH:Neoplasms) |
| pubmed:29024336 | bp(GO:"protein oxidation") increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:"multivesicular body")) |
| pubmed:24563850 | path(MESH:"Cardiovascular Diseases") association bp(GO:"protein oxidation") |
| pubmed:26195256 | path(MESH:"Cardiovascular Diseases") increases path(MESH:"Alzheimer Disease") |
| pubmed:19732809 | path(MESH:"Cardiovascular Diseases") negativeCorrelation p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:24563850 | bp(MESH:"Protein Carbonylation") increases a(MESH:"Protein Aggregates") |
| pubmed:24563850 | act(p(FPLX:PRDX)) decreases a(MESH:"Protein Aggregates") |
| pubmed:25036637 | p(INTERPRO:"Heat shock protein 70 family") directlyIncreases complex(p(HGNC:BAG2), p(HGNC:HSPA8), p(HGNC:RPN1), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) |
| pubmed:25036637 | p(INTERPRO:"Heat shock protein 70 family") directlyIncreases complex(p(HGNC:HSF1), p(HGNC:TP53), p(INTERPRO:"Heat shock protein 70 family")) |
| pubmed:21882945 | p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") |
| pubmed:21882945 | p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:"proteasomal protein catabolic process") |
| pubmed:21882945 | p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:autophagy) |
| pubmed:21882945 | p(INTERPRO:"Heat shock protein 70 family") increases act(p(HGNC:STUB1)) |
| pubmed:21882945 | p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:"protein catabolic process") |
| pubmed:21882945 | p(INTERPRO:"Heat shock protein 70 family") increases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:21882945 | act(p(INTERPRO:"Heat shock protein 70 family"), ma(GO:"ATPase activity")) decreases deg(p(HGNC:MAPT)) |
| pubmed:21882945 | act(p(INTERPRO:"Heat shock protein 70 family")) increases p(HGNC:MAPT) |
| pubmed:21882945 | act(p(INTERPRO:"Heat shock protein 70 family")) increases p(HGNC:MAPT) |
| pubmed:18500754 | p(INTERPRO:"Heat shock protein 70 family") association complex(GO:microtubule) |
| pubmed:25036637 | p(INTERPRO:"Heat shock protein Hsp90 family") association p(INTERPRO:"NudC family") |
| pubmed:25036637 | p(HGNC:DNAJC7) increases complex(p(HGNC:DNAJC7), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pubmed:25036637 | p(HGNC:DNAJB6) increases complex(p(HGNC:DNAJB6), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pubmed:30837838 | p(HGNC:DNAJB6) decreases p(MESH:"Heat-Shock Proteins") |
| pubmed:25036637 | p(HGNC:HSPBP1) increases complex(p(HGNC:HSPBP1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pubmed:25036637 | p(HGNC:EDRF1) increases complex(p(HGNC:EDRF1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pubmed:25036637 | p(HGNC:RNF41) increases complex(p(HGNC:RNF41), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pubmed:25036637 | p(HGNC:CDC37L1) directlyIncreases complex(p(HGNC:CDC37L1), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pubmed:25036637 | p(HGNC:CDC37L1) directlyIncreases complex(p(HGNC:CDC37L1), p(HGNC:STIP1)) |
| pubmed:25036637 | p(INTERPRO:"Cdc37, N-terminal domain") increases act(p(HGNC:CDC37)) |
| pubmed:25036637 | complex(p(HGNC:CDC37L1), p(INTERPRO:"Cdc37, N-terminal domain")) regulates complex(p(HGNC:ARAF), p(HGNC:CDC37L1), p(INTERPRO:"Cdc37, N-terminal domain")) |
| pubmed:25036637 | p(INTERPRO:"Tetratricopeptide repeat") increases complex(a(MESH:"Tacrolimus Binding Proteins"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pubmed:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:AURKB), p(HGNC:FKBP5)) |
| pubmed:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CDK11A), p(HGNC:FKBP5)) |
| pubmed:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CDK1), p(HGNC:FKBP5)) |
| pubmed:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:IKBKG)) |
| pubmed:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CDK4), p(HGNC:FKBP5)) |
| pubmed:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FER), p(HGNC:FKBP5)) |
| pubmed:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:IKBKB)) |
| pubmed:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CHUK), p(HGNC:FKBP5)) |
| pubmed:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:RAF1)) |
| pubmed:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:ABL2), p(HGNC:FKBP5)) |
| pubmed:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:ARAF), p(HGNC:FKBP5)) |
| pubmed:25036637 | p(HGNC:FKBP5) association p(HGNC:CDC37) |
| pubmed:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:AGO1), p(HGNC:FKBP5)) |
| pubmed:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:AGO2), p(HGNC:FKBP5)) |
| pubmed:25036637 | p(HGNC:FKBP5) association p(HGNC:EGLN1) |
| pubmed:25036637 | p(HGNC:FKBP5) association p(HGNC:PDCD2) |
| pubmed:25036637 | p(HGNC:FKBP5) association p(HGNC:ANKMY2) |
| pubmed:25036637 | p(HGNC:FKBP5) increases complex(p(HGNC:FKBP5), p(HGNC:MCM4)) |
| pubmed:25036637 | p(HGNC:FKBP5) increases complex(p(HGNC:FKBP5), p(HGNC:MCMBP)) |
| pubmed:25036637 | p(HGNC:FKBP5) regulates bp(GO:"cellular response to DNA damage stimulus") |
| pubmed:21882945 | p(HGNC:FKBP5) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:21882945 | p(HGNC:FKBP5) increases complex(p(FPLX:HSP90), p(HGNC:MAPT)) |
| pubmed:20071522 | p(HGNC:FKBP5) positiveCorrelation complex(p(FPLX:HSP90), p(HGNC:MAPT)) |
| pubmed:21882945 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:MAPT)) |
| pubmed:20071522 | p(HGNC:FKBP5) isA complex(p(HGNC:FKBP5), p(HGNC:MAPT)) |
| pubmed:21882945 | p(HGNC:FKBP5) positiveCorrelation bp(GO:aging) |
| pubmed:21882945 | p(HGNC:FKBP5) increases p(HGNC:MAPT) |
| pubmed:20071522 | p(HGNC:FKBP5) increases p(HGNC:MAPT) |
| pubmed:21882945 | p(HGNC:FKBP5) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29311797 | p(HGNC:FKBP5) isA a(MESH:Immunophilins) |
| pubmed:20071522 | p(HGNC:FKBP5) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:20071522 | p(HGNC:FKBP5) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:20071522 | p(HGNC:FKBP5) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:20071522 | p(HGNC:FKBP5) negativeCorrelation complex(p(HGNC:AHSA1), p(HGNC:MAPT)) |
| pubmed:20071522 | p(HGNC:FKBP5) decreases complex(p(HGNC:MAPT), p(HGNC:PTGES3)) |
| pubmed:20071522 | p(HGNC:FKBP5) increases bp(GO:"microtubule polymerization") |
| pubmed:10391244 | act(p(HGNC:CDK1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:10391244 | p(HGNC:CDK1) positiveCorrelation complex(GO:"neurofibrillary tangle") |
| pubmed:29686391 | p(HGNC:CDK4) decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:26631930 | p(HGNC:ABL2) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 394)) |
| pubmed:25036637 | p(HGNC:AGO1) directlyIncreases complex(p(HGNC:AGO1), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pubmed:25036637 | p(HGNC:AGO1) directlyIncreases complex(p(HGNC:AGO2), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pubmed:25036637 | p(HGNC:AGO1) positiveCorrelation bp(GO:"ribonucleoprotein complex biogenesis") |
| pubmed:25036637 | p(HGNC:AGO2) positiveCorrelation bp(GO:"ribonucleoprotein complex biogenesis") |
| pubmed:25036637 | bp(GO:"ribonucleoprotein complex biogenesis") positiveCorrelation p(HGNC:AGO1) |
| pubmed:25036637 | bp(GO:"ribonucleoprotein complex biogenesis") positiveCorrelation p(HGNC:AGO2) |
| pubmed:25036637 | p(INTERPRO:"Zinc finger, MYND-type") association p(HGNC:EGLN1) |
| pubmed:25036637 | p(INTERPRO:"Zinc finger, MYND-type") increases complex(p(HGNC:EGLN1), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pubmed:25036637 | p(INTERPRO:"Zinc finger, MYND-type") association p(HGNC:PDCD2) |
| pubmed:25036637 | p(INTERPRO:"Zinc finger, MYND-type") increases complex(p(HGNC:PDCD2), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pubmed:25036637 | p(INTERPRO:"Zinc finger, MYND-type") association p(HGNC:ANKMY2) |
| pubmed:25036637 | p(INTERPRO:"Zinc finger, MYND-type") increases complex(p(HGNC:ANKMY2), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pubmed:25036637 | p(HGNC:PDCD2) association p(HGNC:FKBP5) |
| pubmed:25036637 | p(HGNC:PDCD2) association p(INTERPRO:"Zinc finger, MYND-type") |
| pubmed:25036637 | p(HGNC:ANKMY2) association p(HGNC:FKBP5) |
| pubmed:25036637 | p(HGNC:ANKMY2) association p(INTERPRO:"Zinc finger, MYND-type") |
| pubmed:25036637 | p(HGNC:MCM4) increases bp(GO:"DNA replication initiation") |
| pubmed:25036637 | p(HGNC:MCM4) increases bp(GO:"replication fork progression beyond termination site") |
| pubmed:25036637 | p(HGNC:MCMBP) increases complex(p(HGNC:FKBP5), p(HGNC:MCMBP)) |
| pubmed:25036637 | p(HGNC:MCMBP) increases bp(GO:"DNA replication initiation") |
| pubmed:25036637 | p(HGNC:MCMBP) increases bp(GO:"replication fork progression beyond termination site") |
| pubmed:25036637 | p(HGNC:MCMBP) increases complex(p(HGNC:MCM2), p(HGNC:MCMBP)) |
| pubmed:25036637 | p(HGNC:MCMBP) increases complex(p(HGNC:MCM3), p(HGNC:MCMBP)) |
| pubmed:25036637 | p(HGNC:MCMBP) increases complex(p(HGNC:MCM4), p(HGNC:MCMBP)) |
| pubmed:25036637 | p(HGNC:MCMBP) increases complex(p(HGNC:MCM5), p(HGNC:MCMBP)) |
| pubmed:25036637 | p(HGNC:MCMBP) increases complex(p(HGNC:MCM6), p(HGNC:MCMBP)) |
| pubmed:25036637 | p(HGNC:MCMBP) increases complex(p(HGNC:MCM7), p(HGNC:MCMBP)) |
| pubmed:25036637 | p(HGNC:MCMBP) increases complex(p(HGNC:MCM9), p(HGNC:MCMBP)) |
| pubmed:25036637 | p(HGNC:MCMBP) increases complex(p(HGNC:MCM8), p(HGNC:MCMBP)) |
| pubmed:25036637 | p(HGNC:MCMBP) increases complex(p(HGNC:KEAP1), p(HGNC:MCMBP)) |
| pubmed:23702978 | bp(GO:"cellular response to DNA damage stimulus") increases complex(GO:ripoptosome) |
| pubmed:25036637 | p(HGNC:FKBP8) increases complex(p(HGNC:FKBP8), p(HGNC:PDCL)) |
| pubmed:25036637 | p(HGNC:FKBP8) association bp(GO:"G protein-coupled receptor signaling pathway") |
| pubmed:29311797 | p(HGNC:FKBP8) isA a(MESH:Immunophilins) |
| pubmed:25036637 | p(HGNC:PDCL) association p(INTERPRO:"G-protein, gamma subunit") |
| pubmed:25036637 | p(HGNC:PDCL) isA a(MESH:"Molecular Chaperones") |
| pubmed:25036637 | bp(GO:"G protein-coupled receptor signaling pathway") association p(HGNC:FKBP8) |
| pubmed:25036637 | p(INTERPRO:"G-protein, gamma subunit") association p(HGNC:PDCL) |
| pubmed:25036637 | p(HGNC:FKBP6) increases complex(p(HGNC:FKBP6), p(HGNC:OSBP)) |
| pubmed:29311797 | p(HGNC:FKBP6) isA a(MESH:Immunophilins) |
| pubmed:25036637 | a(CONSO:OSW-1) decreases complex(p(HGNC:FKBP6), p(HGNC:OSBP)) |
| pubmed:25036637 | p(INTERPRO:"BAG domain") regulates act(p(INTERPRO:"Heat shock protein 70 family")) |
| pubmed:25036637 | p(HGNC:LTN1) association bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") |
| pubmed:25036637 | p(HGNC:BAG5) increases complex(p(HGNC:BAG5), p(HGNC:MAD1L1)) |
| pubmed:25036637 | p(HGNC:BAG5) increases complex(p(HGNC:BAG5), p(HGNC:MAD2L1)) |
| pubmed:25036637 | p(HGNC:BAG4) increases complex(p(HGNC:BAG4), p(HGNC:DCP1A)) |
| pubmed:25036637 | p(HGNC:BAG4) increases complex(p(HGNC:BAG4), p(HGNC:EDC3)) |
| pubmed:25036637 | p(HGNC:BAG4) increases complex(p(HGNC:BAG4), p(HGNC:DDX6)) |
| pubmed:25036637 | p(HGNC:BAG4) negativeCorrelation complex(GO:P-body) |
| pubmed:25036637 | p(HGNC:BAG4) directlyIncreases complex(p(HGNC:BAG4), p(HGNC:HSPB1)) |
| pubmed:25036637 | p(HGNC:BAG4) directlyIncreases complex(p(HGNC:BAG4), p(HGNC:DCP1B)) |
| pubmed:25036637 | p(HGNC:DCP1A) isA complex(GO:P-body) |
| pubmed:25036637 | p(HGNC:DCP1A) association bp(GO:"cellular protein catabolic process") |
| pubmed:25036637 | p(HGNC:DCP1A) association bp(GO:"gene silencing") |
| pubmed:25036637 | p(HGNC:DCP1A) decreases bp(GO:"7-methylguanosine mRNA capping") |
| pubmed:25036637 | p(HGNC:DCP1A) decreases bp(GO:"mRNA stabilization") |
| pubmed:25036637 | p(HGNC:DCP1A) increases bp(GO:"translational termination") |
| pubmed:25036637 | p(HGNC:EDC3) isA complex(GO:P-body) |
| pubmed:25036637 | p(HGNC:EDC3) association bp(GO:"cellular protein catabolic process") |
| pubmed:25036637 | p(HGNC:EDC3) association bp(GO:"gene silencing") |
| pubmed:25036637 | p(HGNC:EDC3) decreases bp(GO:"7-methylguanosine mRNA capping") |
| pubmed:25036637 | p(HGNC:EDC3) decreases bp(GO:"mRNA stabilization") |
| pubmed:25036637 | p(HGNC:EDC3) increases bp(GO:"translational termination") |
| pubmed:25036637 | p(HGNC:DDX6) isA complex(GO:P-body) |
| pubmed:25036637 | p(HGNC:DDX6) association bp(GO:"cellular protein catabolic process") |
| pubmed:25036637 | p(HGNC:DDX6) association bp(GO:"gene silencing") |
| pubmed:25036637 | p(HGNC:DDX6) decreases bp(GO:"7-methylguanosine mRNA capping") |
| pubmed:25036637 | p(HGNC:DDX6) decreases bp(GO:"mRNA stabilization") |
| pubmed:25036637 | p(HGNC:DDX6) increases bp(GO:"translational termination") |
| pubmed:25036637 | complex(GO:P-body) negativeCorrelation p(HGNC:BAG4) |
| pubmed:25036637 | complex(GO:P-body) association p(HGNC:BAG4, var("p.Asp424Ala")) |
| pubmed:25036637 | complex(GO:P-body) negativeCorrelation p(HGNC:BAG4, var("p.Asp424Ala")) |
| pubmed:27181519 | complex(GO:P-body) isA complex(GO:"ribonucleoprotein granule") |
| pubmed:27181519 | complex(GO:P-body) regulates a(MESH:"RNA, Messenger") |
| pubmed:27181519 | complex(GO:P-body) association bp(GO:"RNA catabolic process") |
| pubmed:27181519 | complex(GO:P-body) regulates a(MESH:RNA) |
| pubmed:25036637 | p(HGNC:BAG4, var("p.Asp424Ala")) decreases complex(p(HGNC:BAG4, var("p.Asp424Ala")), p(INTERPRO:"Heat shock protein 70 family")) |
| pubmed:25036637 | p(HGNC:BAG4, var("p.Asp424Ala")) association complex(GO:P-body) |
| pubmed:25036637 | p(HGNC:BAG4, var("p.Asp424Ala")) negativeCorrelation complex(GO:P-body) |
| pubmed:25036637 | a(PUBCHEM:23624255) decreases act(p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pubmed:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:RPAP3)) |
| pubmed:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:SUGT1)) |
| pubmed:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:SUGT1)) |
| pubmed:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP4), p(HGNC:HSP90AB1)) |
| pubmed:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP4), p(HGNC:HSP90AB1)) |
| pubmed:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:BAG3), p(HGNC:HSPA8)) |
| pubmed:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:BAG1), p(HGNC:HSPA8)) |
| pubmed:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:BAG4), p(HGNC:HSPA8)) |
| pubmed:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:BAG5), p(HGNC:HSPA8)) |
| pubmed:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:BAG2), p(HGNC:HSPA8)) |
| pubmed:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP5), p(HGNC:HSP90AB1)) |
| pubmed:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:HSPA8), p(HGNC:SUGT1)) |
| pubmed:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP4), p(HGNC:HSPA8)) |
| pubmed:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP5), p(HGNC:HSPA8)) |
| pubmed:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:HSP90AB1), p(HGNC:SIRT6)) |
| pubmed:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:AR), p(HGNC:HSP90AB1)) |
| pubmed:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:HSPA8), p(HGNC:SIRT6)) |
| pubmed:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:AR), p(HGNC:HSPA8)) |
| pubmed:25036637 | p(HGNC:RPAP3) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:RPAP3)) |
| pubmed:25036637 | p(HGNC:RPAP3) directlyIncreases complex(p(HGNC:RPAP3), p(HGNC:RPAP3)) |
| pubmed:25036637 | p(HGNC:RPAP3) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:RPAP3)) |
| pubmed:25036637 | p(HGNC:SUGT1) directlyIncreases complex(p(HGNC:SUGT1), p(INTERPRO:"Leucine-rich repeat domain superfamily")) |
| pubmed:25036637 | p(HGNC:SUGT1) directlyIncreases complex(p(HGNC:SUGT1), p(INTERPRO:"Leucine-rich repeat")) |
| pubmed:29311797 | p(HGNC:FKBP4) isA a(MESH:Immunophilins) |
| pubmed:26631930 | p(HGNC:FKBP4) increases a(CONSO:"Tau aggregates") |
| pubmed:26903089 | act(p(HGNC:FKBP4)) association p(CONSO:"VQIVYK motif") |
| pubmed:21882945 | p(HGNC:BAG2) directlyIncreases complex(p(HGNC:BAG2), p(HGNC:MAPT), p(INTERPRO:"Heat shock protein 70 family")) |
| pubmed:21882945 | p(HGNC:BAG2) association deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:21882945 | p(HGNC:BAG2) decreases act(p(HGNC:STUB1)) |
| pubmed:21882945 | p(HGNC:BAG2) decreases bp(GO:"protein ubiquitination") |
| pubmed:21882945 | p(HGNC:BAG2) decreases complex(p(HGNC:STUB1), p(HGNC:UBA2)) |
| pubmed:25036637 | p(HGNC:PSMC1) directlyIncreases complex(p(HGNC:PSMC1), p(HGNC:PSMC2)) |
| pubmed:25036637 | p(HGNC:PSMC1) directlyIncreases complex(p(HGNC:PSMC1), p(HGNC:PSMD2)) |
| pubmed:25036637 | p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5)) |
| pubmed:25036637 | p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5)) |
| pubmed:25036637 | p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN2)) |
| pubmed:25036637 | p(INTERPRO:"BAG domain superfamily") directlyIncreases complex(p(HGNC:HSPA6), p(INTERPRO:"BAG domain superfamily")) |
| pubmed:25036637 | p(INTERPRO:"BAG domain superfamily") directlyIncreases complex(p(HGNC:HSPA8), p(INTERPRO:"BAG domain superfamily")) |
| pubmed:25036637 | p(HGNC:UNC45A) directlyIncreases complex(p(HGNC:HSP90AB1), p(HGNC:UNC45A)) |
| pubmed:25036637 | p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMD2)) |
| pubmed:25036637 | p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG2), p(HGNC:PSMD2)) |
| pubmed:25036637 | p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG3), p(HGNC:PSMD2)) |
| pubmed:25036637 | p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG5), p(HGNC:PSMD2)) |
| pubmed:25036637 | p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:PSMD2), p(HGNC:STUB1)) |
| pubmed:25036637 | p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:PSMD2), p(INTERPRO:"Heat shock protein 70 family")) |
| pubmed:21882945 | complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) increases deg(p(HGNC:MAPT)) |
| pubmed:25036637 | p(HGNC:VBP1) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:VBP1)) |
| pubmed:25036637 | p(HGNC:VBP1) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:VBP1)) |
| pubmed:25036637 | p(HGNC:VBP1) directlyIncreases complex(p(HGNC:PFDN5), p(HGNC:VBP1)) |
| pubmed:25036637 | p(HGNC:UXT) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:UXT)) |
| pubmed:25036637 | p(HGNC:UXT) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:UXT)) |
| pubmed:25036637 | p(HGNC:UXT) directlyIncreases complex(p(HGNC:PFDN5), p(HGNC:UXT)) |
| pubmed:25036637 | p(HGNC:PDRG1) directlyIncreases complex(p(HGNC:PDRG1), p(HGNC:PFDN2), p(HGNC:PFDN5)) |
| pubmed:25036637 | p(HGNC:PDRG1) directlyIncreases complex(p(HGNC:PDRG1), p(HGNC:PFDN2)) |
| pubmed:25036637 | p(HGNC:PDRG1) directlyIncreases complex(p(HGNC:PDRG1), p(HGNC:PFDN5)) |
| pubmed:25036637 | p(HGNC:POLR3A) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:POLR3A)) |
| pubmed:25036637 | p(HGNC:POLR3A) directlyIncreases complex(p(HGNC:POLR3A), p(HGNC:RPAP3)) |
| pubmed:25036637 | p(HGNC:POLR3A) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:POLR3A)) |
| pubmed:25036637 | p(HGNC:URI1) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:URI1)) |
| pubmed:25036637 | p(HGNC:URI1) directlyIncreases complex(p(HGNC:RPAP3), p(HGNC:URI1)) |
| pubmed:25036637 | p(HGNC:URI1) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:URI1)) |
| pubmed:25036637 | p(INTERPRO:"Leucine-rich repeat domain superfamily") directlyIncreases complex(p(HGNC:SUGT1), p(INTERPRO:"Leucine-rich repeat domain superfamily")) |
| pubmed:25036637 | a(MESH:"Argonaute Proteins") directlyIncreases complex(a(MESH:"Argonaute Proteins"), p(HGNC:PPP5C)) |
| pubmed:25036637 | a(MESH:"Argonaute Proteins") directlyIncreases complex(a(MESH:"Argonaute Proteins"), p(HGNC:PTGES3)) |
| pubmed:21882945 | p(HGNC:PTGES3) increases complex(a(MESH:"Protein Kinases"), p(FPLX:HSP90)) |
| pubmed:29311797 | p(HGNC:PTGES3) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pubmed:29311797 | p(HGNC:PTGES3) decreases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:29311797 | p(HGNC:PTGES3) increases p(HGNC:MAPT) |
| pubmed:29311797 | p(HGNC:PTGES3) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29311797 | p(HGNC:PTGES3) decreases bp(GO:"cell death in response to oxidative stress") |
| pubmed:25036637 | p(INTERPRO:"NudC family") association p(INTERPRO:"Heat shock protein Hsp90 family") |
| pubmed:25036637 | p(HGNC:NUDC) directlyIncreases complex(p(HGNC:NUDC), p(INTERPRO:"WD40-repeat-containing domain superfamily")) |
| pubmed:25036637 | p(HGNC:NUDC) directlyIncreases complex(p(HGNC:NUDC), p(INTERPRO:"WD40-repeat-containing domain")) |
| pubmed:25036637 | p(HGNC:NUDC) directlyIncreases complex(p(HGNC:NUDC), p(INTERPRO:"WD40-repeat-containing domain")) |
| pubmed:25036637 | p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:KLHL13), p(HGNC:NUDCD3)) |
| pubmed:25036637 | p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:KLHL1), p(HGNC:NUDCD3)) |
| pubmed:25036637 | p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:ENC1), p(HGNC:NUDCD3)) |
| pubmed:25036637 | p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:NUDCD3), p(INTERPRO:"Kelch-type beta propeller")) |
| pubmed:25036637 | p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:NUDCD3), p(INTERPRO:"Kelch-type beta propeller")) |
| pubmed:25036637 | p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:FBXO24), p(HGNC:NUDCD2)) |
| pubmed:25036637 | p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:NUDCD2), p(HGNC:SNX31)) |
| pubmed:25036637 | p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:NUDCD2), p(INTERPRO:"Regulator of chromosome condensation, RCC1")) |
| pubmed:25036637 | p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:NUDCD2), p(INTERPRO:"Regulator of chromosome condensation, RCC1")) |
| pubmed:25036637 | p(HGNC:FBXO24) isA p(INTERPRO:"Regulator of chromosome condensation, RCC1") |
| pubmed:25036637 | p(HGNC:CFAP100) directlyIncreases complex(p(HGNC:ARAF), p(HGNC:CDC37)) |
| pubmed:25036637 | p(HGNC:NUDCD1) directlyIncreases complex(p(HGNC:NUDCD1), p(INTERPRO:"DEAD/DEAH box helicase domain")) |
| pubmed:25036637 | p(HGNC:NUDCD1) directlyIncreases complex(a(GO:"COPI-coated vesicle"), p(HGNC:NUDCD1)) |
| pubmed:25036637 | a(GO:"COPI-coated vesicle") regulates bp(GO:"retrograde transport, vesicle recycling within Golgi") |
| pubmed:24706768 | a(CONSO:"polyQ aggregates") decreases act(p(HGNC:DNAJB1)) |
| pubmed:24706768 | a(CONSO:"polyQ aggregates") decreases bp(GO:endocytosis) |
| pubmed:24706768 | a(CONSO:"Q82 aggregates") decreases bp(GO:"clathrin-dependent endocytosis") |
| pubmed:24706768 | p(HGNC:SOD1, var("p.Ala4Val")) decreases bp(GO:"clathrin-dependent endocytosis") |
| pubmed:24706768 | complex(a(CONSO:"protein aggregates"), p(HGNC:HSPA8)) decreases bp(GO:"clathrin-dependent endocytosis") |
| pubmed:28803412 | p(HGNC:SNCA, var("p.Glu46Lys")) increases path(MESH:"Parkinson Disease") |
| pubmed:28803412 | p(HGNC:SNCA, var("p.His50Gln")) increases path(MESH:"Parkinson Disease") |
| pubmed:28803412 | p(HGNC:SNCA, var("p.Gly51Asp")) increases path(MESH:"Parkinson Disease") |
| pubmed:28803412 | p(HGNC:SNCA, var("p.Ala53Glu")) increases path(MESH:"Parkinson Disease") |
| pubmed:28803412 | a(CONSO:CONSO00016) increases path(MESH:"Parkinson Disease") |
| pubmed:27075649 | a(CONSO:CONSO00016) positiveCorrelation path(MESH:"Parkinson Disease") |
| pubmed:27075649 | a(CONSO:CONSO00016) positiveCorrelation path(MESH:"Multiple System Atrophy") |
| pubmed:27075649 | a(CONSO:CONSO00016) positiveCorrelation path(MESH:"Lewy Body Disease") |
| pubmed:28803412 | a(CONSO:CONSO00093) increases path(MESH:"Parkinson Disease") |
| pubmed:28803412 | a(CONSO:CONSO00093) biomarkerFor path(MESH:"Parkinson Disease") |
| pubmed:28803412 | a(CONSO:CONSO00093) positiveCorrelation path(MESH:"Parkinson Disease") |
| pubmed:28803412 | a(CONSO:CONSO00093) increases a(CONSO:CONSO00092) |
| pubmed:27075649 | a(CONSO:CONSO00093) negativeCorrelation a(CONSO:CONSO00092) |
| pubmed:28803412 | a(CONSO:CONSO00093) increases bp(GO:"apoptotic process") |
| pubmed:28803412 | a(CONSO:CONSO00093) increases bp(GO:"apoptotic process") |
| pubmed:27075649 | a(CONSO:CONSO00093) increases bp(GO:"apoptotic process") |
| pubmed:28803412 | a(CONSO:CONSO00093) decreases a(MESH:Mitochondria) |
| pubmed:28803412 | a(CONSO:CONSO00093) increases path(CONSO:CONSO00037) |
| pubmed:28803412 | a(CONSO:CONSO00093) increases bp(MESH:"Endoplasmic Reticulum Stress") |
| pubmed:28803412 | a(CONSO:CONSO00093) decreases act(complex(GO:"proteasome complex")) |
| pubmed:28803412 | a(CONSO:CONSO00093) increases bp(GO:"microglial cell activation") |
| pubmed:28803412 | a(CONSO:CONSO00093) increases bp(GO:"inflammatory response") |
| pubmed:28803412 | a(CONSO:CONSO00093) increases act(p(HGNC:TLR2)) |
| pubmed:28803412 | a(CONSO:CONSO00093) increases a(CHEBI:"reactive oxygen species") |
| pubmed:28803412 | a(CONSO:CONSO00093) decreases a(MESH:"Cell Membrane") |
| pubmed:28803412 | a(CONSO:CONSO00093) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular space"), toLoc(GO:"intracellular part")) |
| pubmed:27075649 | a(CONSO:CONSO00093) increases a(CHEBI:"calcium(2+)") |
| pubmed:28803412 | a(CONSO:CONSO00093) decreases bp(GO:"synaptic vesicle transport") |
| pubmed:28803412 | a(CONSO:CONSO00093) decreases bp(GO:"axonal transport") |
| pubmed:28803412 | a(CONSO:CONSO00093) decreases complex(a(GO:microtubule), a(MESH:Kinesin)) |
| pubmed:28803412 | a(CONSO:CONSO00093) decreases a(MESH:"Golgi Apparatus") |
| pubmed:28803412 | a(CONSO:CONSO00092) causesNoChange bp(GO:"apoptotic process") |
| pubmed:27075649 | a(CONSO:CONSO00092) increases bp(GO:"apoptotic process") |
| pubmed:28803412 | a(CONSO:CONSO00092) increases bp(GO:"inflammatory response") |
| pubmed:28803412 | a(CONSO:CONSO00092) increases bp(GO:"microglial cell activation") |
| pubmed:27075649 | a(CONSO:CONSO00092) increases a(CHEBI:"calcium(2+)") |
| pubmed:27075649 | a(CONSO:CONSO00092) negativeCorrelation a(CONSO:CONSO00093) |
| pubmed:27075649 | a(CONSO:CONSO00092) increases a(CONSO:CONSO00016) |
| pubmed:28803412 | complex(a(CONSO:CONSO00093), p(HGNC:VAMP1)) decreases bp(GO:"SNARE complex assembly") |
| pubmed:26631930 | act(a(MESH:Kinesin)) association p(HGNC:MAPT) |
| pubmed:28803412 | p(HGNC:USP19) increases tloc(p(HGNC:SNCA), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28803412 | a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(CONSO:CONSO00016) |
| pubmed:28803412 | a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(CONSO:CONSO00018) |
| pubmed:28803412 | a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(CONSO:CONSO00017) |
| pubmed:29626319 | a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29626319 | a(CHEBI:"(-)-epigallocatechin 3-gallate") increases r(HGNC:CALCOCO2) |
| pubmed:29626319 | a(CHEBI:"(-)-epigallocatechin 3-gallate") increases r(HGNC:SQSTM1) |
| pubmed:28775333 | a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases p(MGI:Dyrk1a) |
| pubmed:28775333 | a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases p(CONSO:"3R tau") |
| pubmed:28775333 | a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases path(MESH:Anxiety) |
| pubmed:28775333 | a(CHEBI:"(-)-epigallocatechin 3-gallate") positiveCorrelation bp(GO:memory) |
| pubmed:28803412 | p(CONSO:CONSO00094) decreases a(CONSO:CONSO00016) |
| pubmed:28803412 | p(CONSO:CONSO00094) decreases bp(GO:"apoptotic process") |
| pubmed:27075649 | path(MESH:"Multiple System Atrophy") positiveCorrelation a(CONSO:CONSO00016) |
| pubmed:27075649 | a(CONSO:CONSO00095) increases bp(GO:"neuron death") |
| pubmed:27075649 | a(CONSO:CONSO00095) decreases bp(GO:"ion homeostasis") |
| pubmed:27075649 | a(CONSO:CONSO00095) increases a(CONSO:CONSO00016) |
| pubmed:27075649 | a(CHEBI:glutaraldehyde) increases a(CONSO:CONSO00093) |
| pubmed:29807032 | act(p(NCBIGENE:140621)) association bp(MESH:"Heat-Shock Response") |
| pubmed:29807032 | p(NCBIGENE:492507) decreases act(p(NCBIGENE:140621)) |
| pubmed:29807032 | path(MESH:"Stress Disorders, Traumatic") increases r(MESH:"corticotropin releasing factor-binding protein") |
| pubmed:23211705 | p(MGI:Crh) decreases tloc(a(MESH:Estradiol), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:23211705 | p(MGI:Crh) regulates p(HGNC:CGB3) |
| pubmed:23211705 | p(MGI:Crh) decreases p(HGNC:CGB3) |
| pubmed:23211705 | p(MGI:Crh) causesNoChange a(MESH:Progesterone) |
| pubmed:23211705 | p(MGI:Crh) decreases a(MESH:Progesterone) |
| pubmed:23211705 | p(MGI:Crh) decreases a(MESH:Progesterone) |
| pubmed:25125464 | p(MGI:Crh) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:25125464 | p(MGI:Crh) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 204)) |
| pubmed:25125464 | p(MGI:Crh) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:25125464 | p(MGI:Crh) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:25125464 | p(MGI:Crh) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:25125464 | p(MGI:Crh) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:23211705 | composite(a(MESH:antalarmin), p(MGI:Crh)) decreases tloc(p(HGNC:CGB3), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:8940412 | act(p(RGD:Crh)) regulates a(MESH:"Adrenocorticotropic Hormone") |
| pubmed:8940412 | act(p(RGD:Crh)) increases tloc(a(MESH:Glucocorticoids), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:8940412 | act(p(RGD:Crh)) positiveCorrelation bp(GO:"inflammatory response") |
| pubmed:8940412 | act(p(RGD:Crh)) directlyIncreases act(p(RGD:Crhr1)) |
| pubmed:8940412 | a(CHEBI:antalarmin) directlyDecreases act(p(RGD:Crh)) |
| pubmed:8940412 | a(CHEBI:antalarmin) decreases tloc(p(RGD:Crh), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:8940412 | a(CHEBI:antalarmin) directlyDecreases act(p(RGD:Crhr1)) |
| pubmed:8940412 | a(CHEBI:antalarmin) negativeCorrelation bp(GO:"inflammatory response") |
| pubmed:8940412 | act(p(RGD:Crhr2)) decreases act(p(RGD:Crhr1)) |
| pubmed:30145931 | a(CHEBI:"bafilomycin A1") decreases bp(GO:autophagy) |
| pubmed:26702100 | a(CHEBI:"bafilomycin A1") increases p(HGNC:MAP1LC3B) |
| pubmed:26702100 | a(CHEBI:"bafilomycin A1") increases a(GO:autophagosome) |
| pubmed:30145931 | a(CHEBI:epoxomicin) decreases act(p(FPLX:Proteasome)) |
| pubmed:23528736 | a(CHEBI:epoxomicin) decreases act(p(FPLX:Proteasome)) |
| pubmed:30145931 | a(CHEBI:epoxomicin) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) |
| pubmed:30145931 | a(CHEBI:epoxomicin) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:24027553 | a(CHEBI:epoxomicin) increases act(p(HGNC:CASP3)) |
| pubmed:24027553 | a(CHEBI:epoxomicin) decreases deg(p(HGNC:MAPT)) |
| pubmed:24027553 | a(CHEBI:epoxomicin) increases p(HGNC:MAPT) |
| pubmed:23528736 | a(CHEBI:epoxomicin) decreases deg(p(HGNC:MAPT)) |
| pubmed:30145931 | composite(a(CHEBI:epoxomicin), p(HGNC:MAPT)) increases bp(GO:"protein ubiquitination") |
| pubmed:30145931 | composite(a(CHEBI:epoxomicin), p(HGNC:MAPT)) decreases a(MESH:"Dendritic Spines") |
| pubmed:30145931 | a(CHEBI:rolipram) increases act(p(FPLX:Proteasome)) |
| pubmed:30145931 | a(CHEBI:rolipram) decreases p(HGNC:MAPT, loc(MESH:Dendrites)) |
| pubmed:29626319 | a(CHEBI:rolipram) increases deg(p(HGNC:MAPT)) |
| pubmed:29626319 | a(CHEBI:rolipram) increases a(CHEBI:"3',5'-cyclic AMP") |
| pubmed:26692334 | a(CHEBI:rolipram) increases a(CHEBI:"3',5'-cyclic AMP") |
| pubmed:26692334 | a(CHEBI:rolipram) directlyDecreases act(p(FPLX:PDE4)) |
| pubmed:26692334 | a(CHEBI:rolipram) increases act(p(FPLX:PKA)) |
| pubmed:26692334 | a(CHEBI:rolipram) increases act(complex(GO:"proteasome complex")) |
| pubmed:26692334 | a(CHEBI:rolipram) decreases a(CONSO:"Tau aggregates") |
| pubmed:26692334 | a(CHEBI:rolipram) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) |
| pubmed:30145931 | composite(a(CHEBI:wortmannin), p(HGNC:MAPT)) decreases a(MESH:"Dendritic Spines") |
| pubmed:30145931 | a(CHEBI:cycloheximide) decreases bp(GO:translation) |
| pubmed:30145931 | a(CHEBI:cycloheximide) decreases p(HGNC:MAPT, loc(MESH:Dendrites)) |
| pubmed:23702978 | a(CHEBI:cycloheximide) increases bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") |
| pubmed:30145931 | a(CHEBI:"(-)-anisomycin") decreases bp(GO:translation) |
| pubmed:30145931 | a(CHEBI:"(-)-anisomycin") decreases p(HGNC:MAPT, loc(MESH:Dendrites)) |
| pubmed:22072628 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 235)) partOf p(CONSO:"proline-rich region 2", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26996941 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 235)) association act(p(HGNC:PIN1)) |
| pubmed:8282104 | p(CONSO:CONSO00172) directlyIncreases p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:8282104 | complex(p(CONSO:CONSO00172), p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:8282104 | a(CONSO:CONSO00006) association p(HGNC:CDK5) |
| pubmed:8282104 | a(CONSO:CONSO00006) association p(HGNC:PRKACA) |
| pubmed:8282104 | a(CONSO:CONSO00006) association p(FPLX:ERK) |
| pubmed:8282104 | a(CONSO:CONSO00006) association p(FPLX:GSK3) |
| pubmed:27594586 | g(DBSNP:rs63751011) increases p(HGNC:MAP2) |
| pubmed:27594586 | g(DBSNP:rs63751011) causesNoChange a(GO:"symmetric, GABA-ergic, inhibitory synapse") |
| pubmed:27594586 | g(DBSNP:rs63751011) causesNoChange p(HGNC:SLC17A7) |
| pubmed:27594586 | g(DBSNP:rs63751011) causesNoChange p(HGNC:MAPT) |
| pubmed:27594586 | g(DBSNP:rs63751011) causesNoChange p(HGNC:DLGAP4) |
| pubmed:27594586 | g(DBSNP:rs63751011) causesNoChange bp(MESH:"Membrane Potentials") |
| pubmed:27594586 | g(DBSNP:rs63751011) causesNoChange bp(GO:"neuron differentiation") |
| pubmed:27594586 | g(DBSNP:rs63751011) increases act(p(HGNC:MMP9)) |
| pubmed:27594586 | g(DBSNP:rs63751011) increases tloc(p(HGNC:MMP9), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27594586 | g(DBSNP:rs63751011) increases r(HGNC:MMP9) |
| pubmed:27594586 | g(DBSNP:rs63751011) increases r(HGNC:MMP9) |
| pubmed:27594586 | g(DBSNP:rs63751011) increases r(HGNC:MMP2) |
| pubmed:27594586 | g(DBSNP:rs63751011) increases r(HGNC:MMP2) |
| pubmed:27594586 | g(DBSNP:rs63751011) increases bp(GO:"neuron death") |
| pubmed:27594586 | g(DBSNP:rs63751011) increases p(CONSO:CONSO00045) |
| pubmed:27594586 | g(DBSNP:rs63751011) decreases p(CONSO:CONSO00044) |
| pubmed:27594586 | path(MESH:"Neurodevelopmental Disorders") association act(p(HGNC:MMP9)) |
| pubmed:27594586 | a(CHEBI:staurosporine) increases bp(GO:"apoptotic process") |
| pubmed:8726973 | a(CHEBI:staurosporine) decreases act(p(HGNC:CDK5)) |
| pubmed:23666762 | a(CHEBI:staurosporine) decreases complex(p(HGNC:MAPT), p(HGNC:MARK1)) |
| pubmed:23666762 | a(CHEBI:staurosporine) decreases complex(p(HGNC:MAPT), p(HGNC:MARK2)) |
| pubmed:23001711 | a(CHEBI:staurosporine) decreases complex(p(HGNC:MAPT), p(HGNC:MARK2)) |
| pubmed:23666762 | a(CHEBI:staurosporine) decreases complex(p(HGNC:MAPT), p(HGNC:MARK3)) |
| pubmed:23666762 | a(CHEBI:staurosporine) decreases complex(p(HGNC:MAPT), p(HGNC:MARK4)) |
| pubmed:23001711 | a(CHEBI:staurosporine) decreases act(p(HGNC:MARK2), ma(go:0016301 ! "kinase activity")) |
| pubmed:23001711 | a(CHEBI:staurosporine) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:27594586 | a(CHEBI:rotenone) increases path(CONSO:CONSO00037) |
| pubmed:27594586 | composite(a(CHEBI:rotenone), p(HGNC:MAPT, var("p.Ala152Thr"))) causesNoChange bp(GO:"neuron death") |
| pubmed:27594586 | composite(a(CHEBI:staurosporine), p(HGNC:MAPT, var("p.Ala152Thr"))) causesNoChange bp(GO:"neuron death") |
| pubmed:27594586 | a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases p(FPLX:ERK, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27594586 | a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases tloc(p(HGNC:MMP9), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27594586 | a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases act(p(HGNC:MMP9)) |
| pubmed:27594586 | a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") causesNoChange act(p(HGNC:MMP2)) |
| pubmed:27594586 | a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") causesNoChange p(HGNC:MMP2) |
| pubmed:27594586 | p(CONSO:CONSO00045, var("p.Ala152Thr")) increases tloc(p(HGNC:MMP9), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27594586 | p(CONSO:CONSO00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) |
| pubmed:27594586 | p(CONSO:CONSO00045, var("p.Ala152Thr")) increases tloc(p(HGNC:MMP9), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27594586 | p(CONSO:CONSO00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) |
| pubmed:27594586 | p(CONSO:CONSO00045, var("p.Ala152Thr")) increases r(HGNC:MMP9) |
| pubmed:27594586 | p(CONSO:CONSO00045, var("p.Ala152Thr")) increases p(FPLX:ERK, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27594586 | p(CONSO:CONSO00045, var("p.Ala152Thr")) increases bp(GO:"ERK1 and ERK2 cascade") |
| pubmed:27594586 | p(CONSO:CONSO00045, var("p.Ala152Thr")) increases tloc(p(HGNC:MMP2), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27594586 | p(CONSO:CONSO00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP2)) |
| pubmed:27594586 | p(CONSO:CONSO00044, var("p.Ala152Thr")) causesNoChange tloc(p(HGNC:MMP9), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27594586 | p(CONSO:CONSO00044, var("p.Ala152Thr")) causesNoChange act(p(HGNC:MMP9)) |
| pubmed:27594586 | p(CONSO:CONSO00044, var("p.Ala152Thr")) causesNoChange p(FPLX:ERK, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30116051 | composite(a(CHEBI:"NAD(+)"), p(HGNC:SIRT1)) increases bp(GO:macroautophagy) |
| pubmed:30116051 | p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation", Ser, 317)) increases act(p(HGNC:ULK1)) |
| pubmed:30116051 | p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation", Ser, 777)) increases act(p(HGNC:ULK1)) |
| pubmed:30116051 | p(FPLX:mTORC1, pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(FPLX:mTORC1)) |
| pubmed:30116051 | p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation", Ser, 757)) decreases act(p(HGNC:ULK1)) |
| pubmed:30116051 | p(HGNC:AMBRA1, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(HGNC:AMBRA1)) |
| pubmed:30116051 | act(p(HGNC:AMBRA1)) increases bp(GO:"autophagosome assembly") |
| pubmed:30116051 | p(HGNC:LGMN) increases p(HGNC:MAPT, frag("?")) |
| pubmed:30116051 | act(complex(GO:"lysosomal proton-transporting V-type ATPase complex")) negativeCorrelation g(HGNC:PSEN1, var("?")) |
| pubmed:30116051 | p(HGNC:GBA, var("?")) increases path(MESH:"Gaucher Disease") |
| pubmed:30116051 | p(HGNC:GBA, var("?")) decreases bp(GO:macroautophagy) |
| pubmed:30116051 | p(HGNC:GBA, var("?")) increases p(HGNC:SNCA) |
| pubmed:30116051 | p(HGNC:GBA, var("?")) increases path(MESH:"Parkinson Disease") |
| pubmed:30116051 | p(HGNC:C9orf72) association path(MESH:"Frontotemporal Dementia") |
| pubmed:30837838 | p(HGNC:C9orf72) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30116051 | p(HGNC:CHMP2B) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30116051 | p(HGNC:TBK1) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:TBK1) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:27181519 | p(HGNC:TBK1) association path(MESH:"Liver Diseases") |
| pubmed:27181519 | p(HGNC:TBK1) association path(CONSO:Neurodegeneration) |
| pubmed:27181519 | p(HGNC:TBK1) association path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:27181519 | p(HGNC:TBK1) increases path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:27181519 | p(HGNC:TBK1) increases p(HGNC:OPTN, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30116051 | p(HGNC:OPTN, var("?")) decreases bp(GO:"cargo loading into vesicle") |
| pubmed:27181519 | p(HGNC:OPTN, var("?")) association path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:30116051 | p(HGNC:TBK1, var("?")) decreases bp(GO:"cargo loading into vesicle") |
| pubmed:30116051 | p(HGNC:C9orf72, var("?")) decreases bp(GO:autophagy) |
| pubmed:30116051 | a(CHEBI:clonidine) increases bp(GO:autophagy) |
| pubmed:30116051 | a(CHEBI:clonidine) increases deg(p(HGNC:HTT)) |
| pubmed:30116051 | a(CHEBI:Rilmenidine) increases bp(GO:autophagy) |
| pubmed:30116051 | a(CHEBI:Rilmenidine) increases deg(p(HGNC:HTT)) |
| pubmed:30116051 | p(HGNC:CAST) decreases act(p(HGNC:CAPN1)) |
| pubmed:30116051 | p(HGNC:CAST) decreases act(p(HGNC:CAPN2)) |
| pubmed:30116051 | p(HGNC:CAST) increases bp(GO:autophagy) |
| pubmed:30116051 | p(HGNC:CAST) increases deg(p(HGNC:HTT, var("?"))) |
| pubmed:30116051 | p(HGNC:CAST) increases deg(p(HGNC:MAPT)) |
| pubmed:30116051 | p(HGNC:CAST) increases deg(p(HGNC:SNCA)) |
| pubmed:30116051 | p(HGNC:CAST) increases deg(p(HGNC:SOD1)) |
| pubmed:30116051 | a(CHEBI:Calpeptin) decreases act(p(HGNC:CAPN1)) |
| pubmed:30116051 | a(CHEBI:Calpeptin) decreases act(p(HGNC:CAPN2)) |
| pubmed:30116051 | a(CHEBI:Calpeptin) increases bp(GO:autophagy) |
| pubmed:30116051 | a(CHEBI:Calpeptin) increases deg(p(HGNC:HTT, var("?"))) |
| pubmed:30116051 | a(CHEBI:"AICA ribonucleotide") increases act(p(FPLX:AMPK)) |
| pubmed:22419736 | a(CHEBI:"AICA ribonucleotide") increases act(p(FPLX:AMPK)) |
| pubmed:22419736 | a(CHEBI:"AICA ribonucleotide") increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:22419736 | a(CHEBI:"AICA ribonucleotide") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:22419736 | a(CHEBI:"AICA ribonucleotide") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:30116051 | a(PUBCHEM:54708532) increases act(p(FPLX:AMPK)) |
| pubmed:30116051 | a(PUBCHEM:54708532) increases deg(p(HGNC:HTT, var("?"))) |
| pubmed:30116051 | a(PUBCHEM:54708532) increases bp(GO:macroautophagy) |
| pubmed:30116051 | a(CHEBI:"selenium(2+)") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:30116051 | a(CHEBI:selenomethionine) increases bp(GO:autophagy) |
| pubmed:30116051 | a(CHEBI:selenomethionine) increases act(p(FPLX:AMPK)) |
| pubmed:30116051 | a(CHEBI:selenomethionine) increases bp(GO:"autophagosome assembly") |
| pubmed:30116051 | a(CHEBI:selenomethionine) increases bp(GO:"lysosomal microautophagy") |
| pubmed:30116051 | composite(a(CHEBI:"calcium(2+)"), p(HGNC:CAMKK2)) increases p(FPLX:AMPK, pmod(go:0006468 ! "protein phosphorylation", Thr, 172)) |
| pubmed:22419736 | p(FPLX:AMPK, pmod(go:0006468 ! "protein phosphorylation", Thr, 172)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22419736 | p(FPLX:AMPK, pmod(go:0006468 ! "protein phosphorylation", Thr, 172)) negativeCorrelation p(HGNC:AK1) |
| pubmed:30116051 | a(CHEBI:calcitriol) increases act(p(FPLX:AMPK)) |
| pubmed:30116051 | a(CHEBI:calcitriol) increases bp(GO:macroautophagy) |
| pubmed:29626319 | act(a(CHEBI:calcitriol)) increases tloc(a(CHEBI:"amyloid-beta polypeptide 40"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) |
| pubmed:29626319 | a(CHEBI:calcitriol) decreases p(HGNC:AGER) |
| pubmed:29626319 | a(CHEBI:calcitriol) increases p(HGNC:LRP1) |
| pubmed:30116051 | complex(a(CHEBI:sirolimus), p(HGNC:FKBP1A)) decreases act(p(FPLX:mTORC1)) |
| pubmed:23832849 | p(HGNC:FKBP1A) association a(GO:"neurofibrillary tangle") |
| pubmed:23832849 | p(HGNC:FKBP1A) decreases a(CONSO:"Tau aggregates") |
| pubmed:23832849 | p(HGNC:FKBP1A) decreases a(CONSO:"Tau oligomers") |
| pubmed:30116051 | a(CHEBI:fisetin) increases bp(GO:macroautophagy) |
| pubmed:30116051 | a(CHEBI:fisetin) increases act(p(FPLX:mTORC1)) |
| pubmed:30116051 | a(CHEBI:fisetin) decreases a(CHEBI:amyloid-beta) |
| pubmed:30116051 | a(CHEBI:nilotinib) decreases act(p(HGNC:ABL1)) |
| pubmed:30116051 | a(CHEBI:nilotinib) increases bp(GO:macroautophagy) |
| pubmed:30116051 | a(CHEBI:nilotinib) decreases bp(HP:Neurodegeneration) |
| pubmed:30116051 | a(CHEBI:cilostazol) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:30116051 | a(CHEBI:cilostazol) increases bp(GO:macroautophagy) |
| pubmed:30116051 | a(CHEBI:cilostazol) increases act(p(HGNC:BECN1)) |
| pubmed:30116051 | a(CHEBI:cilostazol) increases act(p(HGNC:ATG5)) |
| pubmed:30116051 | a(CHEBI:cilostazol) increases act(p(HGNC:MAP1LC3A)) |
| pubmed:30116051 | a(CHEBI:cilostazol) decreases act(p(FPLX:mTORC1)) |
| pubmed:30116051 | a(CHEBI:cilostazol) increases p(HGNC:CTSB) |
| pubmed:30116051 | a(CHEBI:cilostazol) increases act(p(HGNC:SIRT1)) |
| pubmed:30116051 | a(CHEBI:cilostazol) increases p(FPLX:AMPK, pmod(go:0006468 ! "protein phosphorylation", Tyr, 172)) |
| pubmed:30116051 | composite(a(CHEBI:cilostazol), a(MESH:"amyloid beta-protein (25-35)")) increases bp(GO:cognition) |
| pubmed:30116051 | composite(a(CHEBI:cilostazol), a(MESH:"amyloid beta-protein (25-35)")) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:30116051 | composite(a(CHEBI:cilostazol), a(MESH:"amyloid beta-protein (25-35)")) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:30116051 | a(CHEBI:Isorhynchophylline) increases act(p(HGNC:BECN1)) |
| pubmed:30116051 | a(CHEBI:Isorhynchophylline) increases deg(p(HGNC:SNCA)) |
| pubmed:30116051 | a(CHEBI:Isorhynchophylline) increases bp(GO:macroautophagy) |
| pubmed:30116051 | complex(p(HGNC:BCL2), p(HGNC:BECN1)) decreases bp(GO:macroautophagy) |
| pubmed:30116051 | a(PUBCHEM:16240819) decreases act(p(HGNC:MTMR14)) |
| pubmed:30116051 | a(PUBCHEM:16240819) increases bp(GO:macroautophagy) |
| pubmed:30116051 | a(PUBCHEM:16240819) decreases bp(HP:Neurodegeneration) |
| pubmed:30116051 | p(HGNC:MTMR14) decreases act(p(FPLX:PI3K)) |
| pubmed:30116051 | a(CHEBI:"epothilone A") increases a(GO:microtubule) |
| pubmed:30116051 | a(PUBCHEM:129688311) increases bp(GO:"lysosomal lumen acidification") |
| pubmed:30116051 | a(PUBCHEM:129688311) decreases p(HGNC:SNCA) |
| pubmed:30116051 | a(PUBCHEM:129688311) decreases a(CHEBI:amyloid-beta) |
| pubmed:30116051 | a(CHEBI:"poly(lactic acid) polymer") increases bp(GO:"lysosomal lumen acidification") |
| pubmed:30116051 | a(CHEBI:"poly(D,L-lactic acid-co-glycolic acid)") increases bp(GO:"lysosomal lumen acidification") |
| pubmed:30116051 | a(PUBCHEM:2880983) increases act(p(HGNC:MCOLN1)) |
| pubmed:30116051 | a(CHEBI:chlorohydroquinone) decreases bp(GO:macroautophagy) |
| pubmed:30116051 | a(CHEBI:ambroxol) increases p(HGNC:GBA) |
| pubmed:30116051 | a(CHEBI:ambroxol) increases bp(GO:macroautophagy) |
| pubmed:30116051 | a(CHEBI:ambroxol) increases deg(p(HGNC:SNCA)) |
| pubmed:30116051 | a(CHEBI:ambroxol) decreases p(HGNC:SNCA) |
| pubmed:30116051 | a(CHEBI:ambroxol) decreases bp(GO:"response to endoplasmic reticulum stress") |
| pubmed:30116051 | a(PUBCHEM:9568077) increases act(p(HGNC:HSF1), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) |
| pubmed:30837838 | a(PUBCHEM:9568077) increases act(p(HGNC:HSF1)) |
| pubmed:30837838 | a(PUBCHEM:9568077) decreases p(CONSO:"TDP-43 aggregates") |
| pubmed:30116051 | a(PUBCHEM:46216556) decreases act(p(FPLX:HSP90)) |
| pubmed:30116051 | a(PUBCHEM:46216556) decreases a(CONSO:"huntingtin aggregates") |
| pubmed:30116051 | a(PUBCHEM:46216556) increases path(MESH:"Motor Activity") |
| pubmed:30116051 | a(PUBCHEM:3086599) increases act(complex(GO:"proteasome complex")) |
| pubmed:30116051 | a(PUBCHEM:3086599) increases act(p(FPLX:PKA), ma(go:0016301 ! "kinase activity")) |
| pubmed:30116051 | p(HGNC:PSMC5, pmod(go:0006468 ! "protein phosphorylation", Ser, 120)) increases act(complex(GO:"proteasome complex")) |
| pubmed:30116051 | complex(p(HGNC:BIRC2), p(HGNC:SOD1)) increases deg(p(HGNC:SOD1)) |
| pubmed:23702978 | p(HGNC:BIRC2) decreases complex(GO:ripoptosome) |
| pubmed:30116051 | p(HGNC:PLG) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pubmed:30116051 | p(HGNC:PLG) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:30116051 | p(HGNC:PLG) increases deg(p(HGNC:SNCA)) |
| pubmed:26195256 | p(HGNC:PLG) increases deg(a(CHEBI:amyloid-beta, loc(GO:"extracellular region"))) |
| pubmed:30116051 | p(HGNC:KLK6) increases p(HGNC:SNCA, frag("?")) |
| pubmed:30116051 | a(CHEBI:"(-)-epigallocatechin") increases p(HGNC:IDE) |
| pubmed:30116051 | a(CHEBI:"(-)-epigallocatechin") increases tloc(p(HGNC:IDE), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30116051 | a(CHEBI:"(-)-epigallocatechin") increases act(p(HGNC:IDE)) |
| pubmed:30116051 | a(CHEBI:"(-)-epigallocatechin") increases p(HGNC:MME) |
| pubmed:30116051 | a(CHEBI:"(-)-epigallocatechin") increases tloc(p(HGNC:MME), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30116051 | a(CHEBI:"(-)-epigallocatechin") increases act(p(HGNC:MME)) |
| pubmed:30116051 | a(CHEBI:somatostatin) increases p(HGNC:IDE) |
| pubmed:30116051 | a(CHEBI:somatostatin) increases tloc(p(HGNC:IDE), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30116051 | a(CHEBI:somatostatin) increases act(p(HGNC:IDE)) |
| pubmed:29626319 | a(CHEBI:somatostatin) increases p(HGNC:IDE) |
| pubmed:30116051 | a(CHEBI:somatostatin) increases p(HGNC:MME) |
| pubmed:30116051 | a(CHEBI:somatostatin) increases tloc(p(HGNC:MME), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30116051 | a(CHEBI:somatostatin) increases act(p(HGNC:MME)) |
| pubmed:29626319 | a(CHEBI:somatostatin) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:30116051 | a(CHEBI:rifampicin) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pubmed:30116051 | a(CHEBI:rifampicin) increases act(p(HGNC:LRP1)) |
| pubmed:30116051 | a(CHEBI:rifampicin) increases act(p(FPLX:"GPIb_IX_V")) |
| pubmed:23484434 | a(CHEBI:6872) decreases a(CONSO:CONSO00006) |
| pubmed:23484434 | a(CHEBI:8028) causesNoChange a(CONSO:CONSO00006) |
| pubmed:23484434 | a(CHEBI:44932) causesNoChange a(CONSO:CONSO00006) |
| pubmed:23484434 | a(CHEBI:3647) causesNoChange a(CONSO:CONSO00006) |
| pubmed:23484434 | a(CHEBI:87637) decreases a(CONSO:CONSO00006) |
| pubmed:23484434 | a(CHEBI:22580) decreases a(CONSO:CONSO00006) |
| pubmed:23484434 | a(CHEBI:1457) decreases a(CONSO:CONSO00018) |
| pubmed:23484434 | a(CHEBI:10642) decreases a(CONSO:CONSO00018) |
| pubmed:23484434 | a(CHEBI:4806) decreases a(CONSO:CONSO00018) |
| pubmed:23484434 | a(CHEBI:4806) decreases a(CONSO:CONSO00006) |
| pubmed:23484434 | a(CHEBI:74460) decreases a(CONSO:CONSO00018) |
| pubmed:23484434 | a(CONSO:CONSO00021) decreases a(CONSO:CONSO00018) |
| pubmed:23484434 | a(CONSO:CONSO00019) decreases a(CONSO:CONSO00018) |
| pubmed:23484434 | a(CHEBI:90) causesNoChange a(CONSO:CONSO00006) |
| pubmed:23484434 | a(CHEBI:18152) decreases a(CONSO:CONSO00006) |
| pubmed:23484434 | a(CHEBI:3441) decreases a(CONSO:CONSO00018) |
| pubmed:23484434 | a(CHEBI:3441) decreases a(CONSO:CONSO00006) |
| pubmed:23484434 | a(CHEBI:6710) decreases a(CONSO:CONSO00006) |
| pubmed:23484434 | a(CHEBI:6710) decreases a(CONSO:CONSO00018) |
| pubmed:23484434 | a(CHEBI:76034) increases complex(a(CHEBI:76034), a(GO:"GO:0097418")) |
| pubmed:23484434 | a(CHEBI:76034) decreases a(CONSO:CONSO00006) |
| pubmed:23484434 | a(CHEBI:112284) decreases a(CONSO:CONSO00006) |
| pubmed:23484434 | a(CONSO:CONSO00020) decreases a(CONSO:CONSO00006) |
| pubmed:29024336 | path(MESH:"Proteostasis Deficiencies") decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) |
| pubmed:29024336 | bp(GO:"late endosomal microautophagy") increases deg(p(MGI:Mapt)) |
| pubmed:29024336 | bp(GO:"late endosomal microautophagy") increases deg(p(MGI:Mapt)) |
| pubmed:29024336 | bp(GO:"late endosomal microautophagy") increases deg(p(CONSO:CONSO00053)) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Mapt) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases a(CONSO:CONSO00006) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases a(CONSO:CONSO00100) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) decreases complex(a(GO:lysosome), p(MGI:Mapt)) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) decreases complex(a(GO:lysosome), p(MGI:Mapt)) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) decreases bp(GO:"late endosomal microautophagy") |
| pubmed:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases deg(a(MESH:Proteins)) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases deg(a(MESH:Proteins)) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"chaperone-mediated autophagy") |
| pubmed:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases a(GO:autophagosome) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases a(GO:autolysosome) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:macroautophagy) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:macroautophagy) |
| pubmed:24027553 | p(MGI:Mapt, var("p.Pro301Leu")) increases path(CONSO:Neurodegeneration) |
| pubmed:24027553 | p(MGI:Mapt, var("p.Pro301Leu")) positiveCorrelation p(HGNC:NPEPPS) |
| pubmed:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:H2afx) |
| pubmed:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cdkn1a) |
| pubmed:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cdkn2a) |
| pubmed:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Il1b) |
| pubmed:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cxcl1) |
| pubmed:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Tnf) |
| pubmed:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Tlr4) |
| pubmed:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"NIK/NF-kappaB signaling") |
| pubmed:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Rela) |
| pubmed:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Glb1) |
| pubmed:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases path(MESH:Tauopathies) |
| pubmed:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases a(GO:"neurofibrillary tangle") |
| pubmed:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"cellular senescence") |
| pubmed:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) association bp(MESH:"Cerebrovascular Circulation") |
| pubmed:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases bp(MESH:"Cerebrovascular Circulation") |
| pubmed:29121589 | p(MGI:Mapt, var("p.Pro301Leu")) increases path(CONSO:Astrogliosis) |
| pubmed:29121589 | p(MGI:Mapt, var("p.Pro301Leu")) increases path(CONSO:Microgliosis) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases p(MGI:Mapt) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases a(CONSO:CONSO00009) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) decreases bp(GO:"late endosomal microautophagy") |
| pubmed:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) decreases bp(GO:"late endosomal microautophagy") |
| pubmed:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt, var("p.Ala152Thr"))) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases deg(a(MESH:Proteins)) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases deg(a(MESH:Proteins)) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases deg(a(MESH:Proteins)) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases bp(GO:"chaperone-mediated autophagy") |
| pubmed:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases a(GO:autophagosome) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases a(GO:autolysosome) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases bp(GO:macroautophagy) |
| pubmed:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases bp(GO:macroautophagy) |
| pubmed:29024336 | complex(a(GO:lysosome), p(MGI:Mapt, var("p.Pro301Leu"))) increases tloc(p(MGI:Mapt, var("p.Pro301Leu")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pubmed:29024336 | complex(a(GO:lysosome), p(MGI:Snca, var("?"))) decreases tloc(p(MGI:Snca, var("?")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pubmed:29024336 | complex(a(GO:lysosome), p(MGI:Lrrk2, var("?"))) decreases tloc(p(MGI:Lrrk2, var("?")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pubmed:29024336 | a(CHEBI:paraquat) increases bp(GO:"response to oxidative stress") |
| pubmed:28019679 | a(CHEBI:paraquat) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:28019679 | a(CHEBI:paraquat) increases p(HGNC:CASP1) |
| pubmed:28019679 | a(CHEBI:paraquat) increases p(HGNC:IL1B) |
| pubmed:29024336 | composite(a(CHEBI:thapsigargin), p(CONSO:CONSO00053)) increases bp(GO:"chaperone-mediated autophagy") |
| pubmed:29024336 | composite(a(CHEBI:paraquat), p(CONSO:CONSO00053)) increases bp(GO:"chaperone-mediated autophagy") |
| pubmed:29024336 | composite(a(CHEBI:paraquat), p(MGI:Mapt, var("p.Pro301Leu"))) decreases bp(GO:"chaperone-mediated autophagy") |
| pubmed:29024336 | composite(a(CHEBI:thapsigargin), p(MGI:Mapt, var("p.Pro301Leu"))) decreases bp(GO:"chaperone-mediated autophagy") |
| pubmed:29024336 | composite(a(CHEBI:thapsigargin), p(MGI:Mapt, var("p.Ala152Thr"))) causesNoChange bp(GO:"chaperone-mediated autophagy") |
| pubmed:29024336 | composite(a(CHEBI:paraquat), p(MGI:Mapt, var("p.Ala152Thr"))) causesNoChange bp(GO:"chaperone-mediated autophagy") |
| pubmed:29024336 | composite(a(CHEBI:"ammonium chloride"), a(CHEBI:leupeptin)) decreases bp(GO:"late endosomal microautophagy") |
| pubmed:29024336 | p(CONSO:CONSO00057) increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pubmed:29024336 | p(CONSO:CONSO00057) increases bp(GO:"chaperone-mediated autophagy") |
| pubmed:29024336 | p(CONSO:CONSO00055) increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pubmed:29024336 | p(CONSO:CONSO00055) decreases deg(p(MGI:Mapt)) |
| pubmed:29024336 | p(CONSO:CONSO00055) decreases bp(GO:"late endosomal microautophagy") |
| pubmed:29024336 | p(CONSO:CONSO00054) decreases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pubmed:29024336 | p(CONSO:CONSO00053, var("p.Lys280del")) increases a(CONSO:CONSO00006) |
| pubmed:29024336 | p(CONSO:CONSO00053, var("p.Lys280del")) decreases deg(p(HGNC:MAPT)) |
| pubmed:29024336 | p(CONSO:CONSO00053, var("p.Lys280del")) decreases tloc(p(CONSO:CONSO00053, var("p.Lys280del")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pubmed:29024336 | p(CONSO:CONSO00053, var("p.Lys280delinsProPro")) increases tloc(p(CONSO:CONSO00053, var("p.Lys280del")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pubmed:29024336 | p(CONSO:CONSO00053, var("p.Lys280delinsProPro")) decreases a(CONSO:CONSO00006) |
| pubmed:29024336 | p(CONSO:CONSO00053, var("p.Lys280delinsProPro")) decreases tloc(p(CONSO:CONSO00053, var("p.Lys280Pro")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pubmed:29024336 | p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) decreases tloc(p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pubmed:29024336 | p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) decreases deg(p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205))) |
| pubmed:29024336 | p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation", Ser, 214), pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) decreases tloc(p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation", Ser, 214), pmod(go:0006468 ! "protein phosphorylation", Thr, 212)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pubmed:29024336 | p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation", Ser, 214), pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) decreases deg(p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation", Ser, 214), pmod(go:0006468 ! "protein phosphorylation", Thr, 212))) |
| pubmed:29024336 | p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) decreases tloc(p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pubmed:29024336 | p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) decreases deg(p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404))) |
| pubmed:29024336 | p(CONSO:CONSO00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) decreases tloc(p(CONSO:CONSO00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pubmed:29024336 | p(CONSO:CONSO00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) decreases deg(p(CONSO:CONSO00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))) |
| pubmed:29024336 | p(CONSO:CONSO00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")) increases tloc(p(CONSO:CONSO00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pubmed:29215007 | p(CONSO:CONSO00166) increases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pubmed:29215007 | complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) positiveCorrelation p(CONSO:CONSO00169) |
| pubmed:29215007 | composite(complex(GO:"filamentous actin"), p(HGNC:CFL1)) decreases complex(GO:"filamentous actin") |
| pubmed:24760868 | complex(GO:"filamentous actin") association p(HGNC:MAPT) |
| pubmed:24760868 | complex(GO:"filamentous actin") increases p(HGNC:MAPT) |
| pubmed:24760868 | complex(GO:"filamentous actin") increases p(HGNC:MAPT, loc(GO:synapse)) |
| pubmed:19118186 | complex(GO:"filamentous actin") negativeCorrelation complex(p(MGI:Cdk5), p(MGI:Cdk5r1)) |
| pubmed:29215007 | p(CONSO:CONSO00169) positiveCorrelation complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pubmed:29215007 | p(CONSO:CONSO00169) positiveCorrelation complex(a(GO:"filamentous actin"), p(HGNC:CFL1)) |
| pubmed:29215007 | p(CONSO:CONSO00169) positiveCorrelation complex(a(MESH:Actins), p(HGNC:CFL1)) |
| pubmed:29215007 | complex(a(GO:"filamentous actin"), p(HGNC:CFL1)) positiveCorrelation p(CONSO:CONSO00169) |
| pubmed:29215007 | complex(a(MESH:Actins), p(HGNC:CFL1)) positiveCorrelation p(CONSO:CONSO00169) |
| pubmed:29215007 | a(MESH:Endopeptidases) increases p(HGNC:MAPT, var("?")) |
| pubmed:29215007 | p(HGNC:MAPT, frag("244_372")) increases bp(GO:"actin filament bundle assembly") |
| pubmed:29215007 | p(HGNC:MAPT, frag("254_290")) increases bp(GO:"actin filament bundle assembly") |
| pubmed:29215007 | p(HGNC:MAPT, frag("254_290")) increases bp(GO:"actin filament bundle assembly") |
| pubmed:29215007 | p(HGNC:MAPT, frag("254_290")) increases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) |
| pubmed:29215007 | p(HGNC:MAPT, frag("260_268")) increases bp(MESH:"Protein Structure, Secondary") |
| pubmed:29215007 | p(HGNC:MAPT, frag("277_283")) increases bp(MESH:"Protein Structure, Secondary") |
| pubmed:29215007 | p(HGNC:MAPT, frag("277_283")) increases bp(MESH:"Protein Conformation, alpha-Helical") |
| pubmed:29215007 | p(HGNC:MAPT, frag("261_268")) increases bp(MESH:"Protein Conformation, alpha-Helical") |
| pubmed:22072628 | bp(MESH:"Protein Conformation, alpha-Helical") positiveCorrelation p(CONSO:"proline-rich region 2", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22072628 | bp(MESH:"Protein Conformation, alpha-Helical") association p(HGNC:MAPT, frag("235_324")) |
| pubmed:29215007 | p(HGNC:MAPT, frag("277_280")) increases p(CONSO:CONSO00170) |
| pubmed:29215007 | p(HGNC:MAPT, frag("261_265")) increases p(CONSO:CONSO00170) |
| pubmed:29215007 | complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("261_268"))) increases bp(MESH:"Protein Conformation, alpha-Helical") |
| pubmed:29215007 | complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("277_280"))) increases p(CONSO:CONSO00170) |
| pubmed:29215007 | complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("261_265"))) increases p(CONSO:CONSO00170) |
| pubmed:29215007 | complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("277_283"))) increases bp(MESH:"Protein Conformation, alpha-Helical") |
| pubmed:29215007 | p(HGNC:MAPT, var("p.Leu256Glu")) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) |
| pubmed:29215007 | p(HGNC:MAPT, var("p.Leu256Glu")) decreases bp(GO:"actin filament bundle assembly") |
| pubmed:29215007 | complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) increases bp(MESH:"Protein Conformation, alpha-Helical") |
| pubmed:29215007 | p(HGNC:MAPT, frag("292_319")) increases bp(GO:"actin filament bundle assembly") |
| pubmed:29215007 | p(HGNC:MAPT, frag("315_318")) increases p(CONSO:CONSO00170) |
| pubmed:29215007 | complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_268"))) increases bp(MESH:"Protein Conformation, alpha-Helical") |
| pubmed:29215007 | p(HGNC:MAPT, frag("254_268")) decreases bp(GO:"actin filament bundle assembly") |
| pubmed:29215007 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 293)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pubmed:29215007 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 293)) decreases bp(GO:"actin filament bundle assembly") |
| pubmed:17493042 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 293)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) |
| pubmed:17493042 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 293)) decreases p(CONSO:"Tau aggregates") |
| pubmed:17493042 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 293)) decreases bp(GO:"neurofibrillary tangle assembly") |
| pubmed:24251416 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 293)) partOf p(CONSO:"tubulin-binding repeat 2") |
| pubmed:29215007 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 305)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pubmed:29215007 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 305)) decreases bp(GO:"actin filament bundle assembly") |
| pubmed:24251416 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 305)) partOf p(CONSO:"tubulin-binding repeat 2") |
| pubmed:29215007 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 416)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pubmed:29215007 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 416)) decreases bp(GO:"actin filament bundle assembly") |
| pubmed:24027553 | p(HGNC:MAPT, pmod(CONSO:nitration)) association path(MESH:"Neurofibrillary Tangles") |
| pubmed:24027553 | act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT)) |
| pubmed:24027553 | act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT)) |
| pubmed:24027553 | a(CHEBI:Thrombin) increases bp(GO:coagulation) |
| pubmed:24027553 | a(CHEBI:Thrombin) increases path(CONSO:"neurite retraction") |
| pubmed:24027553 | a(CHEBI:Thrombin) increases bp(GO:"apoptotic process") |
| pubmed:24027553 | a(CHEBI:Thrombin) increases bp(GO:"apoptotic process") |
| pubmed:24027553 | a(CHEBI:Thrombin) increases a(CONSO:"Tau aggregates") |
| pubmed:24027553 | a(CHEBI:Thrombin, loc(MESH:Neurons)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24027553 | a(CHEBI:Thrombin, loc(MESH:Astrocytes)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:24027553 | a(CHEBI:Thrombin) association path(MESH:"Neurofibrillary Tangles") |
| pubmed:24027553 | act(a(CHEBI:Thrombin)) increases p(HGNC:MAPT, frag("1_?")) |
| pubmed:24027553 | act(a(CHEBI:Thrombin)) causesNoChange p(HGNC:MAPT, frag("561_685")) |
| pubmed:24027553 | act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT, frag("561_685"))) |
| pubmed:24027553 | act(a(CHEBI:Thrombin)) increases act(p(HGNCGENEFAMILY:Caspases)) |
| pubmed:24027553 | act(p(HGNC:HTRA1)) increases deg(p(HGNC:MAPT)) |
| pubmed:24027553 | act(p(HGNC:HTRA1)) increases deg(p(HGNC:MAPT)) |
| pubmed:29626319 | p(HGNC:HTRA1) increases deg(p(HGNC:MAPT)) |
| pubmed:24027553 | p(HGNC:HTRA1) association bp(CONSO:"APP processing") |
| pubmed:24027553 | p(HGNC:HTRA1) association path(MESH:"Alzheimer Disease") |
| pubmed:24027553 | act(p(HGNC:HTRA1)) increases deg(p(HGNCGENEFAMILY:Tubulins)) |
| pubmed:24027553 | act(p(HGNC:HTRA1)) regulates act(a(MESH:Microtubules)) |
| pubmed:24027553 | act(p(HGNC:HTRA1)) increases deg(a(CONSO:"Tau fibrils")) |
| pubmed:24027553 | act(p(HGNC:HTRA1)) increases deg(a(CONSO:"Tau aggregates")) |
| pubmed:24027553 | p(HGNC:NPEPPS) increases act(p(HGNCGENEFAMILY:Aminopeptidases)) |
| pubmed:24027553 | p(HGNC:NPEPPS) association path(MESH:Tauopathies) |
| pubmed:24027553 | p(HGNC:NPEPPS) decreases path(MESH:Tauopathies) |
| pubmed:24027553 | p(HGNC:NPEPPS) positiveCorrelation p(MGI:Mapt, var("p.Pro301Leu")) |
| pubmed:24027553 | p(HGNC:NPEPPS) decreases p(MGI:Mapt, var("p.Pro301Leu")) |
| pubmed:24027553 | p(HGNC:NPEPPS) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pubmed:24027553 | p(HGNC:NPEPPS) decreases p(HGNC:MAPT) |
| pubmed:24027553 | p(HGNC:NPEPPS) regulates deg(p(HGNC:MAPT)) |
| pubmed:24027553 | p(HGNC:NPEPPS) increases deg(p(HGNC:MAPT)) |
| pubmed:24027553 | p(HGNC:NPEPPS) decreases path(MESH:Paralysis) |
| pubmed:24027553 | p(HGNC:NPEPPS) decreases path(MESH:Gliosis) |
| pubmed:24027553 | p(HGNC:NPEPPS) increases p(HGNC:MAPT, frag("1_?")) |
| pubmed:24027553 | p(HGNC:NPEPPS) increases p(HGNC:MAPT, frag("?_*")) |
| pubmed:24027553 | p(HGNC:NPEPPS) increases bp(GO:autophagy) |
| pubmed:24027553 | p(HGNC:NPEPPS) increases bp(GO:"autophagosome assembly") |
| pubmed:24027553 | p(HGNC:PIN1) association path(MESH:"Alzheimer Disease") |
| pubmed:23157676 | act(p(HGNC:PIN1)) decreases path(MESH:"Alzheimer Disease") |
| pubmed:24027553 | p(HGNC:PIN1) decreases deg(p(HGNC:MAPT, var("p.Pro301Leu"))) |
| pubmed:26751493 | p(HGNC:PIN1) association p(CONSO:"projection domain") |
| pubmed:25899010 | p(HGNC:PIN1) decreases path(CONSO:Excitotoxicity) |
| pubmed:25899010 | p(HGNC:PIN1) decreases path(CONSO:Neurodegeneration) |
| pubmed:24964035 | p(HGNC:PIN1) regulates deg(p(HGNC:SMAD2)) |
| pubmed:24964035 | p(HGNC:PIN1) increases complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:SMAD2)) |
| pubmed:23157676 | act(p(HGNC:PIN1)) decreases p(CONSO:"cis p-tau") |
| pubmed:26996941 | act(p(HGNC:PIN1)) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 235)) |
| pubmed:19401603 | p(HGNC:PIN1) increases act(p(HGNC:PPP2CA)) |
| pubmed:24027553 | deg(p(HGNC:MAPT, frag("561_685"))) increases a(CONSO:"Tau aggregates") |
| pubmed:24027553 | p(HGNC:MAPT, frag("561_685")) positiveCorrelation a(CONSO:"Tau aggregates") |
| pubmed:24027553 | p(CONSO:"cis p-tau") decreases deg(p(CONSO:"cis p-tau")) |
| pubmed:24027553 | p(CONSO:"cis p-tau") decreases act(p(HGNC:PIN1)) |
| pubmed:23157676 | p(CONSO:"cis p-tau") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23157676 | p(CONSO:"cis p-tau") increases a(CONSO:"Tau aggregates") |
| pubmed:24027553 | p(HGNC:MAPT, frag("?", "17kD")) increases path(CONSO:"neurite retraction") |
| pubmed:24027553 | p(HGNC:MAPT, frag("?", "17kD")) causesNoChange path(CONSO:neurotoxicity) |
| pubmed:24027553 | a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "17kD")) |
| pubmed:24027553 | a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "35kD")) |
| pubmed:24027553 | a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "24kD")) |
| pubmed:24027553 | a(CHEBI:"calpain inhibitor") decreases act(p(HGNCGENEFAMILY:Calpains)) |
| pubmed:24027553 | p(HGNC:MAPT, var("p.Asp421*")) isA p(CONSO:"Tau C3") |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Asp421*")) partOf a(GO:"neurofibrillary tangle") |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Asp421*")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26671985 | p(HGNC:MAPT, var("p.Asp421*")) biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy") |
| pubmed:26671985 | p(HGNC:MAPT, var("p.Asp421*")) association path(CONSO:neurotoxicity) |
| pubmed:24027553 | p(HGNC:MAPT, var("p.Asp421Glu")) decreases bp(GO:"apoptotic process") |
| pubmed:24027553 | composite(a(MESH:"Amyloid beta-Peptides"), p(HGNC:CASP3)) increases p(CONSO:"Tau C3") |
| pubmed:24027553 | a(MESH:"9-deoxy-delta-9-prostaglandin D2") increases act(p(HGNCGENEFAMILY:Caspases)) |
| pubmed:24027553 | act(a(MESH:"Proteasome Endopeptidase Complex")) increases deg(p(HGNC:MAPT)) |
| pubmed:24027553 | a(CHEBI:N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal) increases p(HGNC:MAPT) |
| pubmed:24027553 | a(CHEBI:N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal) decreases act(a(CHEBI:"Hsp90 inhibitor")) |
| pubmed:30837838 | a(CHEBI:N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal) increases path(MESH:"Stress, Physiological") |
| pubmed:24027553 | act(a(CHEBI:"Hsp90 inhibitor")) decreases p(HGNC:MAPT) |
| pubmed:21882945 | a(CHEBI:"Hsp90 inhibitor") increases deg(p(HGNC:MAPT)) |
| pubmed:21882945 | a(CHEBI:"Hsp90 inhibitor") increases complex(a(MESH:Proteins), p(FPLX:HSP90)) |
| pubmed:24027553 | bp(GO:"vacuolar acidification") increases bp(GO:proteolysis) |
| pubmed:24027553 | bp(GO:"vacuolar acidification") increases bp(GO:autophagy) |
| pubmed:24027553 | bp(GO:"vacuolar acidification") decreases a(MESH:Autophagosomes) |
| pubmed:24027553 | composite(p(HGNC:CTSD), p(HGNC:MAPT)) decreases p(HGNC:MAPT) |
| pubmed:24027553 | composite(p(HGNC:CTSD), p(HGNC:MAPT)) increases p(HGNC:MAPT, frag("?")) |
| pubmed:24027553 | a(MESH:3-methyladenine) decreases bp(GO:"autophagosome assembly") |
| pubmed:24027553 | a(MESH:3-methyladenine) increases p(HGNC:MAPT) |
| pubmed:24027553 | bp(MESH:Autophagy) increases deg(p(HGNC:MAPT)) |
| pubmed:24027553 | bp(MESH:Autophagy) causesNoChange p(HGNC:MAPT) |
| pubmed:24027553 | bp(MESH:Autophagy) increases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:24027553 | bp(MESH:Autophagy) increases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:24027553 | bp(MESH:Autophagy) decreases p(HGNC:MAPT, var("p.Pro301Leu")) |
| pubmed:24027553 | bp(MESH:Autophagy) decreases a(CONSO:"Tau aggregates") |
| pubmed:24027553 | bp(MESH:Autophagy) increases deg(a(CONSO:"Tau aggregates")) |
| pubmed:24027553 | bp(MESH:Autophagy) increases deg(a(CONSO:"Tau aggregates")) |
| pubmed:24027553 | bp(MESH:Autophagy) increases deg(a(CONSO:"Tau aggregates")) |
| pubmed:24027553 | bp(MESH:Autophagy) decreases p(MGI:Mapt, var("p.Pro301Ser")) |
| pubmed:24027553 | bp(MESH:Autophagy) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 212), var("p.Pro301Ser")) |
| pubmed:24027553 | bp(MESH:Autophagy) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 214), var("p.Pro301Ser")) |
| pubmed:24027553 | bp(MESH:Autophagy) negativeCorrelation bp(GO:"neuron death") |
| pubmed:24027553 | bp(MESH:Autophagy) increases deg(p(CONSO:"Tau C3")) |
| pubmed:24027553 | bp(MESH:Autophagy) decreases p(CONSO:"Tau C3") |
| pubmed:24027553 | bp(MESH:Autophagy) decreases p(CONSO:"Tau epitope, AT8") |
| pubmed:24027553 | bp(MESH:Autophagy) decreases p(CONSO:"Tau epitope, PHF1") |
| pubmed:24027553 | bp(MESH:Autophagy) decreases p(CONSO:"Tau epitope, 12E8") |
| pubmed:24027553 | bp(MESH:Autophagy) increases deg(a(CONSO:"Tau oligomers")) |
| pubmed:24027553 | a(MESH:Trehalose) increases bp(MESH:Autophagy) |
| pubmed:24027553 | a(MESH:Trehalose) increases bp(MESH:Autophagy) |
| pubmed:24027553 | a(MESH:Trehalose) increases bp(MESH:Autophagy) |
| pubmed:24027553 | a(MESH:Trehalose) decreases a(CONSO:"Tau aggregates") |
| pubmed:24027553 | a(MESH:Trehalose) decreases p(HGNC:MAPT) |
| pubmed:24027553 | composite(a(MESH:Ubiquitin), p(HGNC:MAPT)) increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:16176937 | p(RGD:Mapt) isA complex(p(RGD:Klc1), p(RGD:Mapt)) |
| pubmed:16176937 | p(RGD:Mapt) isA complex(p(RGD:Klc2), p(RGD:Mapt)) |
| pubmed:20133804 | act(p(RGD:Mapt)) increases bp(GO:"microtubule polymerization") |
| pubmed:20133804 | act(p(RGD:Mapt)) increases bp(GO:"neuron projection development") |
| pubmed:22156579 | p(CONSO:"Tau epitope, PHF1") positiveCorrelation p(CONSO:"Tau epitope, 12E8") |
| pubmed:22156579 | p(CONSO:"Tau epitope, PHF1") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:22156579 | p(CONSO:"Tau epitope, PHF1") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:24033439 | p(CONSO:"Tau epitope, PHF1") biomarkerFor path(MESH:"Alzheimer Disease") |
| pubmed:24033439 | p(CONSO:"Tau epitope, PHF1") increases p(CONSO:"Tau aggregates") |
| pubmed:27574109 | bp(GO:"positive regulation of protein oligomerization") positiveCorrelation p(CONSO:"4R tau") |
| pubmed:27574109 | bp(GO:"positive regulation of protein oligomerization") positiveCorrelation p(CONSO:"3R tau") |
| pubmed:27574109 | p(CONSO:"Tau isoform Fetal-tau (352 aa)") association p(CONSO:"phosphatase-activating domain") |
| pubmed:27574109 | p(CONSO:"Tau isoform Fetal-tau (352 aa)") positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:27574109 | p(CONSO:"Tau isoform Fetal-tau (352 aa)") increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | p(CONSO:"Tau isoform Fetal-tau (352 aa)") increases a(CONSO:"Tau oligomers") |
| pubmed:29191965 | p(CONSO:"Tau isoform Fetal-tau (352 aa)") decreases bp(GO:locomotion) |
| pubmed:17493042 | p(CONSO:"Tau isoform Fetal-tau (352 aa)") partOf a(MESH:Brain) |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") association p(CONSO:"Tau isoform Fetal-tau (352 aa)") |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform Fetal-tau (352 aa)") |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") association p(CONSO:"Tau isoform D (383 aa)") |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform D (383 aa)") |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") association p(CONSO:"Tau isoform C (410 aa)") |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform C (410 aa)") |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", pmod(CONSO:"protein aggregation")) |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", pmod(CONSO:"protein aggregation")) |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform C (410 aa)", pmod(CONSO:"protein aggregation")) |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform C (410 aa)", pmod(CONSO:"protein aggregation")) |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform Fetal-tau (352 aa)", pmod(CONSO:"protein aggregation")) |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform Fetal-tau (352 aa)", pmod(CONSO:"protein aggregation")) |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform B (381 aa)", pmod(CONSO:"protein aggregation")) |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform B (381 aa)", pmod(CONSO:"protein aggregation")) |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:"protein aggregation")) |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:"protein aggregation")) |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform E (412 aa)", pmod(CONSO:"protein aggregation")) |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform B (381 aa)") |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform F (441 aa)") |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform E (412 aa)") |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") association a(CONSO:pretangles) |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") association a(CONSO:"Braak_Stage I") |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") association a(CONSO:"Braak_Stage II") |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") association a(MESH:"Neurofibrillary Tangles") |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") association path(CONSO:"Corticobasal Degeneration") |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") positiveCorrelation path(CONSO:"Corticobasal Degeneration") |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") association a(GO:"Pick body") |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") positiveCorrelation path(MESH:Tauopathies) |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pubmed:21734277 | p(CONSO:"phosphatase-activating domain") increases act(p(CONSO:"Tau 6D")) |
| pubmed:21734277 | p(CONSO:"phosphatase-activating domain") decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:21734277 | p(CONSO:"phosphatase-activating domain") decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:21734277 | p(CONSO:"phosphatase-activating domain") decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:21734277 | p(CONSO:"phosphatase-activating domain") causesNoChange bp(GO:"retrograde axonal protein transport") |
| pubmed:21734277 | p(CONSO:"phosphatase-activating domain") decreases p(HGNC:JUN, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21734277 | p(CONSO:"phosphatase-activating domain") increases act(p(MESH:"Phosphoprotein Phosphatases")) |
| pubmed:21734277 | p(CONSO:"phosphatase-activating domain") increases act(p(MESH:"Glycogen Synthase Kinase 3")) |
| pubmed:21734277 | p(CONSO:"phosphatase-activating domain") increases act(p(MESH:"Glycogen Synthase Kinase 3")) |
| pubmed:21734277 | p(CONSO:"phosphatase-activating domain") increases act(p(MESH:"Glycogen Synthase Kinase 3")) |
| pubmed:21734277 | p(CONSO:"phosphatase-activating domain") increases act(p(MESH:"Protein Phosphatase 1")) |
| pubmed:21734277 | p(CONSO:"phosphatase-activating domain") increases act(p(MESH:"Protein Phosphatase 1")) |
| pubmed:21734277 | p(CONSO:"phosphatase-activating domain") association a(CONSO:"Tau antibody, TNT1") |
| pubmed:26671985 | p(CONSO:"phosphatase-activating domain") equivalentTo p(HGNC:MAPT, frag("2_18")) |
| pubmed:26671985 | p(CONSO:"phosphatase-activating domain") negativeCorrelation act(complex(GO:axon)) |
| pubmed:26671985 | p(CONSO:"phosphatase-activating domain") biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy") |
| pubmed:26671985 | p(CONSO:"phosphatase-activating domain") decreases bp(GO:"axonal transport") |
| pubmed:21734277 | p(CONSO:"phosphatase-activating domain") negativeCorrelation bp(GO:"axonal transport") |
| pubmed:27260838 | p(CONSO:"phosphatase-activating domain") association p(CONSO:"Tau antibody, TNT1") |
| pubmed:27260838 | p(CONSO:"phosphatase-activating domain") association p(CONSO:"Tau antibody, TNT2") |
| pubmed:27574109 | p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"4R tau") |
| pubmed:27373205 | p(CONSO:"phosphatase-activating domain") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:21734277 | p(CONSO:"phosphatase-activating domain") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:21734277 | p(CONSO:"phosphatase-activating domain") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:21734277 | p(CONSO:"phosphatase-activating domain") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:21734277 | p(CONSO:"phosphatase-activating domain") increases act(p(FPLX:PPP1)) |
| pubmed:21734277 | p(CONSO:"phosphatase-activating domain") increases act(p(HGNC:GSK3B)) |
| pubmed:27574109 | p(CONSO:"Tau isoform D (383 aa)", pmod(CONSO:"protein aggregation")) positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:27574109 | p(CONSO:"Tau isoform D (383 aa)", pmod(CONSO:"protein aggregation")) positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:27574109 | p(CONSO:"Tau isoform D (383 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | p(CONSO:"Tau isoform D (383 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | p(CONSO:"Tau isoform D (383 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | p(CONSO:"Tau isoform D (383 aa)", pmod(CONSO:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pubmed:27574109 | p(CONSO:"Tau isoform D (383 aa)", pmod(CONSO:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pubmed:27574109 | p(CONSO:"Tau isoform D (383 aa)", pmod(CONSO:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") |
| pubmed:27574109 | p(CONSO:"Tau isoform C (410 aa)", pmod(CONSO:"protein aggregation")) positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:27574109 | p(CONSO:"Tau isoform C (410 aa)", pmod(CONSO:"protein aggregation")) positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:27574109 | p(CONSO:"Tau isoform C (410 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | p(CONSO:"Tau isoform C (410 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | p(CONSO:"Tau isoform C (410 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | p(CONSO:"Tau isoform C (410 aa)", pmod(CONSO:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pubmed:27574109 | p(CONSO:"Tau isoform C (410 aa)", pmod(CONSO:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pubmed:27574109 | p(CONSO:"Tau isoform C (410 aa)", pmod(CONSO:"protein aggregation")) decreases bp(GO:"retrograde axonal transport") |
| pubmed:27574109 | p(CONSO:"Tau isoform Fetal-tau (352 aa)", pmod(CONSO:"protein aggregation")) positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:27574109 | p(CONSO:"Tau isoform Fetal-tau (352 aa)", pmod(CONSO:"protein aggregation")) positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:27574109 | p(CONSO:"Tau isoform Fetal-tau (352 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | p(CONSO:"Tau isoform Fetal-tau (352 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | p(CONSO:"Tau isoform Fetal-tau (352 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | p(CONSO:"Tau isoform Fetal-tau (352 aa)", pmod(CONSO:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pubmed:27574109 | p(CONSO:"Tau isoform Fetal-tau (352 aa)", pmod(CONSO:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") |
| pubmed:27574109 | p(CONSO:"Tau isoform B (381 aa)", pmod(CONSO:"protein aggregation")) positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:27574109 | p(CONSO:"Tau isoform B (381 aa)", pmod(CONSO:"protein aggregation")) positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:27574109 | p(CONSO:"Tau isoform B (381 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | p(CONSO:"Tau isoform B (381 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | p(CONSO:"Tau isoform B (381 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | p(CONSO:"Tau isoform B (381 aa)", pmod(CONSO:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pubmed:27574109 | p(CONSO:"Tau isoform B (381 aa)", pmod(CONSO:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") |
| pubmed:27574109 | p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:"protein aggregation")) positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:27574109 | p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:"protein aggregation")) positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:27574109 | p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pubmed:27574109 | p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") |
| pubmed:27574109 | p(CONSO:"Tau isoform E (412 aa)", pmod(CONSO:"protein aggregation")) positiveCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:27574109 | p(CONSO:"Tau isoform E (412 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | p(CONSO:"Tau isoform E (412 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | p(CONSO:"Tau isoform E (412 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") |
| pubmed:27574109 | p(CONSO:"Tau isoform E (412 aa)", pmod(CONSO:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pubmed:27574109 | p(CONSO:"Tau isoform E (412 aa)", pmod(CONSO:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pubmed:27574109 | p(CONSO:"Tau isoform E (412 aa)", pmod(CONSO:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") |
| pubmed:27574109 | a(CONSO:"Braak_Stage I") association a(CONSO:"Tau oligomers") |
| pubmed:27574109 | a(CONSO:"Braak_Stage I") association p(CONSO:"phosphatase-activating domain") |
| pubmed:27574109 | a(CONSO:"Braak_Stage I") association p(HGNC:MAPT) |
| pubmed:28176663 | a(CONSO:"Braak_Stage I") positiveCorrelation act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:27574109 | composite(p(CONSO:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27574109 | composite(p(CONSO:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pubmed:27574109 | composite(p(CONSO:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation path(CONSO:"Corticobasal Degeneration") |
| pubmed:17403556 | a(CONSO:"amyloid-beta derived diffusible ligands") decreases bp(MESH:"Cell Survival") |
| pubmed:17403556 | a(CONSO:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:17403556 | a(CONSO:"amyloid-beta derived diffusible ligands") increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:17403556 | a(CONSO:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:17403556 | a(CONSO:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:17403556 | a(CONSO:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:17403556 | a(CONSO:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:17403556 | a(CONSO:"amyloid-beta derived diffusible ligands") increases complex(a(CONSO:"amyloid-beta derived diffusible ligands"), a(GO:synapse)) |
| pubmed:17403556 | a(CONSO:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:17403556 | a(CONSO:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:17403556 | a(CONSO:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:17403556 | a(CONSO:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:17403556 | a(CONSO:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) |
| pubmed:26195256 | deg(a(CONSO:"amyloid-beta derived diffusible ligands")) decreases a(CONSO:"amyloid-beta derived diffusible ligands") |
| pubmed:26195256 | tloc(a(CONSO:"amyloid-beta derived diffusible ligands"), fromLoc(GO:"extracellular region"), toLoc(MESH:"Intracellular Space")) decreases a(CONSO:"amyloid-beta derived diffusible ligands") |
| pubmed:26195256 | tloc(a(CONSO:"amyloid-beta derived diffusible ligands"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) decreases a(CONSO:"amyloid-beta derived diffusible ligands") |
| pubmed:26195256 | tloc(a(CONSO:"amyloid-beta derived diffusible ligands"), fromLoc(MESH:Blood), toLoc(MESH:"Cerebrospinal Fluid")) decreases a(CONSO:"amyloid-beta derived diffusible ligands") |
| pubmed:26195256 | tloc(a(CONSO:"amyloid-beta derived diffusible ligands"), fromLoc(MESH:Brain), toLoc(MESH:"Extracellular Fluid")) decreases a(CONSO:"amyloid-beta derived diffusible ligands") |
| pubmed:26195256 | tloc(a(CONSO:"amyloid-beta derived diffusible ligands"), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Cardiovascular System")) decreases a(CONSO:"amyloid-beta derived diffusible ligands") |
| pubmed:26195256 | tloc(a(CONSO:"amyloid-beta derived diffusible ligands"), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymphatic System")) decreases a(CONSO:"amyloid-beta derived diffusible ligands") |
| pubmed:18096814 | a(CONSO:"amyloid-beta derived diffusible ligands") increases tloc(p(MGI:Fyn), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) |
| pubmed:18096814 | a(CONSO:"amyloid-beta derived diffusible ligands") increases tloc(p(MGI:Mapt), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) |
| pubmed:30985105 | p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation p(RGD:Mapt, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:20133804 | p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(RGD:Fkbp4) |
| pubmed:29421605 | p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation bp(GO:aging) |
| pubmed:17403556 | a(CONSO:"amyloid-beta antibody, NU1") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:17403556 | a(CONSO:"amyloid-beta antibody, NU1") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:17403556 | a(CONSO:"amyloid-beta antibody, NU1") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:17403556 | a(CONSO:"amyloid-beta antibody, NU1") decreases complex(a(CONSO:"amyloid-beta derived diffusible ligands"), a(MESH:Neurons)) |
| pubmed:17403556 | a(CONSO:"amyloid-beta antibody, NU1") decreases complex(a(CONSO:"amyloid-beta derived diffusible ligands"), a(MESH:Neurons)) |
| pubmed:17403556 | a(CONSO:"amyloid-beta antibody, NU1") decreases complex(a(CONSO:"amyloid-beta derived diffusible ligands"), a(GO:synapse)) |
| pubmed:17403556 | a(MESH:"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:17403556 | a(MESH:"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine") decreases bp(GO:"signal transduction") |
| pubmed:17403556 | a(MESH:"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine") decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:17403556 | a(CHEBI:LY294002) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:17403556 | a(CHEBI:LY294002) decreases bp(GO:"signal transduction") |
| pubmed:17403556 | a(CHEBI:LY294002) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:17403556 | complex(a(CONSO:"amyloid-beta derived diffusible ligands"), p(HGNC:MAPT)) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) association a(GO:"somatodendritic compartment") |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange a(GO:"neurofibrillary tangle") |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange a(GO:"dendritic spine") |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange a(CHEBI:ATP) |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange act(a(GO:presynapse)) |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases a(GO:mitochondrion) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Hippocampus) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Hippocampus) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Hippocampus) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases bp(GO:neurogenesis) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) negativeCorrelation act(a(MESH:Microglia)) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases act(a(MESH:Microglia)) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange act(a(MESH:Microglia)) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange path(MESH:Inflammation) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Mapt) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Mapt) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases tloc(p(MGI:Mapt), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Mapt) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:"Stem Cells") |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases bp(GO:"neuron differentiation") |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases p(MGI:Wnt5a) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Wnt3) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Wnt3) |
| pubmed:27671637 | a(GO:"somatodendritic compartment") association p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) |
| pubmed:27671637 | a(GO:"somatodendritic compartment") association p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(GO:"somatodendritic compartment") |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(HP:"Argyrophilic inclusion bodies") |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(HP:"Argyrophilic inclusion bodies") |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(MESH:Axons) |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"), loc(MESH:Dendrites)) decreases a(GO:"dendritic spine") |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:"dendritic spine") |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"), loc(MESH:Dendrites)) decreases act(a(GO:dendrite)) |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:"mitochondrial transport") |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:mitochondrion) |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:mitochondrion) |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:mitochondrion) |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(CHEBI:ATP) |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(CHEBI:ATP) |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation act(a(MESH:Neurons)) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) |
| pubmed:28528849 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Fos) |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation bp(GO:"astrocyte activation") |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Gfap) |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation bp(GO:"response to oxidative stress") |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Hmox1) |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases act(a(GO:presynapse)) |
| pubmed:27671637 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:"spontaneous synaptic transmission") |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(CONSO:"Tau aggregates") |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:synapse) |
| pubmed:28528849 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:synapse) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) increases path(CONSO:Neurodegeneration) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation act(a(MESH:Microglia)) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(MESH:Microglia) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) increases act(a(MESH:Microglia)) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) increases path(MESH:Inflammation) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) increases path(MESH:Hypertrophy) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) increases tloc(p(MGI:Mapt), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange p(MGI:Mapt) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange p(MGI:Mapt) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) increases tloc(p(MGI:Mapt), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange a(MESH:"Stem Cells") |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) increases bp(GO:"neuron differentiation") |
| pubmed:29202785 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Hippocampus) |
| pubmed:28528849 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:memory) |
| pubmed:28528849 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(CONSO:"Tau fibrils") |
| pubmed:28528849 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(CONSO:"Tau oligomers") |
| pubmed:28528849 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) increases p(CONSO:"Tau oligomers", var("p.Lys280del")) |
| pubmed:28528849 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange a(CHEBI:"reactive oxygen species") |
| pubmed:28528849 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange a(CHEBI:"calcium(2+)", loc(GO:intracellular)) |
| pubmed:27671637 | a(HP:"Argyrophilic inclusion bodies") association p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pubmed:27671637 | a(HP:"Argyrophilic inclusion bodies") positiveCorrelation p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pubmed:27671637 | a(HP:"Argyrophilic inclusion bodies") causesNoChange p(MGI:Syp) |
| pubmed:27671637 | p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) decreases complex(a(GO:microtubule), p(MGI:Mapt)) |
| pubmed:27671637 | complex(a(HP:"Argyrophilic inclusion bodies"), p(MGI:Mapt)) decreases deg(p(MGI:Mapt)) |
| pubmed:27671637 | p(MGI:Fos) negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pubmed:27671637 | p(MGI:Fos) biomarkerFor act(a(MESH:Neurons)) |
| pubmed:27671637 | p(MGI:Gfap) negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pubmed:27671637 | p(MGI:Gfap) biomarkerFor bp(GO:"astrocyte activation") |
| pubmed:27671637 | p(MGI:Hmox1) negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pubmed:27671637 | p(MGI:Hmox1) biomarkerFor bp(GO:"response to oxidative stress") |
| pubmed:27671637 | a(CHEBI:adenosine) increases act(p(MGI:Adora1)) |
| pubmed:27671637 | a(CHEBI:adenosine) decreases act(a(MESH:Neurons)) |
| pubmed:27671637 | a(CHEBI:adenosine) decreases p(MGI:Fos) |
| pubmed:27671637 | a(CHEBI:adenosine) decreases act(a(GO:presynapse)) |
| pubmed:27671637 | a(CHEBI:adenosine) decreases bp(GO:"long-term synaptic potentiation") |
| pubmed:21882945 | a(CHEBI:adenosine) decreases act(p(INTERPRO:"Heat shock protein 70 family")) |
| pubmed:27671637 | act(p(MGI:Adora1)) decreases act(a(MESH:Neurons)) |
| pubmed:27671637 | act(p(MGI:Adora1)) decreases act(a(GO:presynapse)) |
| pubmed:27671637 | act(p(MGI:Adora1)) decreases bp(GO:"long-term synaptic potentiation") |
| pubmed:27671637 | a(PUBCHEM:64627) decreases act(p(MGI:Adora1)) |
| pubmed:27671637 | a(PUBCHEM:64627) increases act(a(MESH:Neurons)) |
| pubmed:27671637 | a(PUBCHEM:64627) increases r(MGI:Fos) |
| pubmed:27671637 | a(PUBCHEM:64627) increases act(a(GO:presynapse)) |
| pubmed:27671637 | a(PUBCHEM:64627) causesNoChange a(GO:"dendritic spine") |
| pubmed:27671637 | a(PUBCHEM:64627) decreases a(GO:mitochondrion) |
| pubmed:27671637 | a(MESH:"BSc 3094") increases act(a(GO:presynapse)) |
| pubmed:27671637 | composite(a(PUBCHEM:64627), p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"))) decreases a(GO:"dendritic spine") |
| pubmed:27671637 | composite(a(PUBCHEM:64627), p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"))) causesNoChange a(GO:"dendritic spine") |
| pubmed:27671637 | composite(a(PUBCHEM:64627), p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"))) causesNoChange a(GO:"dendritic spine") |
| pubmed:27671637 | composite(a(PUBCHEM:64627), p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"))) causesNoChange act(a(GO:presynapse)) |
| pubmed:27671637 | composite(a(PUBCHEM:64627), p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"))) causesNoChange act(a(MESH:Neurons)) |
| pubmed:27671637 | composite(a(PUBCHEM:64627), p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"))) causesNoChange p(MGI:Fos) |
| pubmed:27671637 | composite(a(PUBCHEM:64627), p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"))) causesNoChange path(MESH:"Spatial Memory") |
| pubmed:27671637 | composite(a(PUBCHEM:64627), p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"long-term memory") |
| pubmed:27671637 | composite(a(PUBCHEM:64627), p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"))) causesNoChange bp(GO:"associative learning") |
| pubmed:27671637 | composite(a(PUBCHEM:64627), p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"excitatory postsynaptic potential") |
| pubmed:27671637 | composite(a(PUBCHEM:64627), p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"spontaneous synaptic transmission") |
| pubmed:27671637 | composite(a(PUBCHEM:64627), p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del"))) causesNoChange a(GO:"dendritic spine") |
| pubmed:28784767 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 208)) partOf p(CONSO:"Tau epitope, AT8") |
| pubmed:22833681 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 208)) partOf p(CONSO:"Tau epitope, AT8") |
| pubmed:28784767 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 208)) decreases a(CONSO:"Tau Protein Secondary Structure, Turn") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 208)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22833681 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 208)) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) |
| pubmed:28784767 | p(HGNC:MAPT, var("p.Gly207Val")) increases a(CONSO:"Tau aggregates") |
| pubmed:28784767 | p(HGNC:MAPT, var("p.Gly207Val")) decreases a(CONSO:"Tau Protein Secondary Structure, Turn") |
| pubmed:28784767 | p(HGNC:MAPT, var("p.Gly207Val")) increases p(CONSO:"Tau aggregates") |
| pubmed:28784767 | a(CONSO:"Tau Protein Secondary Structure, Turn") decreases a(CONSO:"Tau aggregates") |
| pubmed:28784767 | a(CONSO:"Tau Protein Secondary Structure, Turn") decreases a(CONSO:"Tau aggregates") |
| pubmed:28784767 | a(CONSO:"Tau Protein Secondary Structure, Turn") decreases p(CONSO:"Tau aggregates") |
| pubmed:28784767 | a(CONSO:"Tau Protein Secondary Structure, Turn") decreases p(CONSO:"Tau aggregates") |
| pubmed:28784767 | act(p(FPLX:CSNK1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 208)) |
| pubmed:25673844 | p(FPLX:CSNK1) isA p(CONSO:"CK1 superfamily") |
| pubmed:25673844 | p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 42)) |
| pubmed:25673844 | p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 45)) |
| pubmed:25673844 | p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 47)) |
| pubmed:25673844 | p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 80)) |
| pubmed:25673844 | p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 81)) |
| pubmed:25673844 | p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Thr, 84)) |
| pubmed:28784767 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205), pmod(go:0006468 ! "protein phosphorylation", Thr, 208)) equivalentTo p(CONSO:"Tau epitope, AT8") |
| pubmed:29590627 | a(CHEBI:dextran) increases tloc(a(CHEBI:dextran)) |
| pubmed:28420982 | a(CHEBI:dextran) association a(CONSO:"Tau aggregates") |
| pubmed:29590627 | a(CHEBI:dynasore) decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:29590627 | a(CHEBI:dynasore) decreases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:29590627 | a(CHEBI:dynasore) decreases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:29686391 | a(CHEBI:dynasore) decreases act(p(HGNC:DNM2)) |
| pubmed:29686391 | a(CHEBI:dynasore) decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29590627 | a(CHEBI:"cytochalasin D") decreases bp(GO:"actin filament polymerization") |
| pubmed:29590627 | a(CHEBI:"cytochalasin D") negativeCorrelation bp(GO:"bulk synaptic vesicle endocytosis") |
| pubmed:29590627 | a(CHEBI:"cytochalasin D") negativeCorrelation bp(GO:macropinocytosis) |
| pubmed:29590627 | a(CHEBI:"cytochalasin D") decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:29590627 | a(CHEBI:"cytochalasin D") causesNoChange tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:29590627 | a(CHEBI:"cytochalasin D") causesNoChange tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:29590627 | bp(GO:"actin filament polymerization") positiveCorrelation bp(GO:"bulk synaptic vesicle endocytosis") |
| pubmed:29590627 | bp(GO:"actin filament polymerization") positiveCorrelation bp(GO:macropinocytosis) |
| pubmed:29590627 | bp(GO:"actin filament polymerization") increases tloc(a(CONSO:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:24760868 | bp(GO:"actin filament polymerization") increases complex(GO:"filamentous actin") |
| pubmed:27041503 | bp(GO:"actin filament polymerization") increases bp(MESH:"Long-Term Potentiation") |
| pubmed:29590627 | composite(a(CHEBI:dynasore), p(HGNC:MAPT, var("p.Pro301Ser"))) causesNoChange tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:29590627 | composite(a(CHEBI:"cytochalasin D"), p(HGNC:MAPT, var("p.Pro301Ser"))) decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pubmed:22611162 | p(HGNC:MAPT, var("p.Lys280del")) increases a(CONSO:"Tau aggregates") |
| pubmed:22611162 | p(HGNC:MAPT, var("p.Lys280del")) increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Lys280del")) increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Lys280del")) increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Lys280del")) increases a(CONSO:"Tau aggregates") |
| pubmed:22611162 | p(HGNC:MAPT, var("p.Lys280del")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22611162 | p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:locomotion) |
| pubmed:22611162 | p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"dorsal spinal cord development") |
| pubmed:22611162 | p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"dorsal spinal cord development") |
| pubmed:22611162 | p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"ventral spinal cord development") |
| pubmed:22611162 | p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"ventral spinal cord development") |
| pubmed:22611162 | p(HGNC:MAPT, var("p.Lys280del")) increases path(CONSO:neurotoxicity) |
| pubmed:22611162 | p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"nervous system development") |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Lys280del")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Lys280del")) decreases p(CONSO:"4R tau") |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Lys280del")) increases p(CONSO:"3R tau") |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:memory) |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Lys280del")) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Lys280del")) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Lys280del")) increases a(GO:"neurofibrillary tangle") |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:cognition) |
| pubmed:11606569 | p(HGNC:MAPT, var("p.Lys280del")) equivalentTo g(DBSNP:rs63750688) |
| pubmed:11606569 | p(HGNC:MAPT, var("p.Lys280del")) positiveCorrelation p(CONSO:"VQIINK motif") |
| pubmed:11606569 | p(HGNC:MAPT, var("p.Lys280del")) positiveCorrelation p(CONSO:"VQIVYK motif") |
| pubmed:22611162 | p(HGNC:MAPT, var("p.Ile277Pro")) decreases a(CONSO:"Tau aggregates") |
| pubmed:22611162 | p(HGNC:MAPT, var("p.Ile308Pro")) decreases a(CONSO:"Tau aggregates") |
| pubmed:22611162 | p(HGNC:MAPT, var("p.Val277Met")) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:22611162 | p(HGNC:MAPT, var("p.Val277Met")) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:22611162 | p(HGNC:MAPT, var("p.Val277Met")) increases path(CONSO:neurotoxicity) |
| pubmed:22611162 | p(HGNC:MAPT, var("p.Val277Met")) decreases bp(GO:"nervous system development") |
| pubmed:22611162 | a(PUBCHEM:25096749) increases bp(GO:locomotion) |
| pubmed:22611162 | a(PUBCHEM:25096749) decreases a(CONSO:"Tau aggregates") |
| pubmed:22611162 | a(CONSO:bb14) increases bp(GO:locomotion) |
| pubmed:22611162 | a(CONSO:cmp16) decreases a(CONSO:"Tau fibrils") |
| pubmed:22611162 | a(CONSO:cmp16) increases bp(GO:locomotion) |
| pubmed:22611162 | a(CONSO:cmp16) decreases path(HP:Neurodegeneration) |
| pubmed:24760868 | p(MESH:Actins) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pubmed:24760868 | p(MESH:Actins) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pubmed:17187063 | complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) increases complex(GO:"filamentous actin") |
| pubmed:17187063 | complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) positiveCorrelation path(CONSO:Neurodegeneration) |
| pubmed:24760868 | a(MESH:jasplakinolide) increases bp(GO:"actin filament polymerization") |
| pubmed:24760868 | a(MESH:jasplakinolide) increases bp(GO:"actin filament polymerization") |
| pubmed:24760868 | a(MESH:jasplakinolide) increases p(HGNC:MAPT) |
| pubmed:24760868 | a(MESH:jasplakinolide) increases p(HGNC:GRIA1) |
| pubmed:24760868 | a(MESH:jasplakinolide) decreases p(HGNC:FYN) |
| pubmed:24760868 | a(CHEBI:"latrunculin A") increases bp(GO:"actin filament depolymerization") |
| pubmed:24760868 | a(CHEBI:"latrunculin A") increases bp(GO:"actin filament depolymerization") |
| pubmed:24760868 | a(CHEBI:"latrunculin A") decreases p(HGNC:MAPT) |
| pubmed:29202785 | a(CHEBI:doxycycline) decreases p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) |
| pubmed:29202785 | a(CHEBI:doxycycline) decreases p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) |
| pubmed:29202785 | a(CHEBI:doxycycline) decreases p(MGI:Wnt5a) |
| pubmed:29202785 | a(CHEBI:doxycycline) decreases p(MGI:Wnt3) |
| pubmed:21734277 | p(CONSO:"Tau 6D") decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:21734277 | p(CONSO:"Tau 6D") decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:21734277 | act(p(CONSO:"Tau 6D")) decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:21734277 | p(CONSO:"Tau 6D") causesNoChange bp(GO:"retrograde axonal protein transport") |
| pubmed:21734277 | p(CONSO:"Tau 6D") increases act(p(MESH:"Protein Phosphatase 1")) |
| pubmed:21734277 | p(CONSO:"Tau 6D") increases act(p(MESH:"Glycogen Synthase Kinase 3")) |
| pubmed:21734277 | p(CONSO:"Tau 6P") decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:21734277 | p(CONSO:"Tau 6P") causesNoChange bp(GO:"retrograde axonal protein transport") |
| pubmed:21734277 | act(p(MESH:"Protein Phosphatase 1")) decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:21734277 | act(p(MESH:"Protein Phosphatase 1")) decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:21734277 | act(p(MESH:"Glycogen Synthase Kinase 3")) decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:21734277 | act(p(MESH:"Glycogen Synthase Kinase 3")) decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:21734277 | act(p(MESH:"Glycogen Synthase Kinase 3")) decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:21734277 | composite(p(CONSO:"phosphatase-activating domain"), p(HGNC:PPP1R2)) increases bp(GO:"anterograde axonal protein transport") |
| pubmed:21734277 | p(CONSO:"Tau epitope, AT8", pmod(go:0006468 ! "protein phosphorylation")) association p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:21734277 | p(CONSO:"Tau epitope, AT8", pmod(go:0006468 ! "protein phosphorylation")) association path(MESH:Tauopathies) |
| pubmed:21734277 | p(HGNC:MAPT, var("p.Gly144_Ser273del")) decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:21734277 | p(HGNC:MAPT, var("p.Gly144_Ser273del")) causesNoChange bp(GO:"retrograde axonal protein transport") |
| pubmed:21734277 | a(CONSO:"Tau antibody, TNT1") association p(CONSO:"phosphatase-activating domain") |
| pubmed:27373205 | a(CONSO:"Tau antibody, TNT1") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) increases p(CONSO:"Tau fibrils", var("p.Lys280del")) |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) increases bp(GO:"cell death") |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) causesNoChange bp(GO:"cell death") |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) increases bp(GO:"apoptotic process") |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) increases bp(GO:"negative regulation of mitochondrial membrane potential") |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) increases act(p(HGNC:CASP3)) |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) increases act(p(HGNC:CASP7)) |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) increases tloc(p(HGNC:CYCS), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) causesNoChange a(GO:membrane) |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines") |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines") |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines") |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines") |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) decreases a(GO:postsynapse) |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) decreases p(HGNC:GRIA1) |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) decreases p(HGNC:DBN1) |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) decreases p(HGNC:SYP) |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) increases a(CHEBI:"reactive oxygen species") |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) increases a(CHEBI:"reactive oxygen species") |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) increases p(HGNC:NOX1) |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) increases act(complex(GO:"NADPH oxidase complex")) |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:CYBB) |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) causesNoChange tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"cell body")) |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) causesNoChange tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) |
| pubmed:28528849 | p(CONSO:"Tau oligomers", var("p.Lys280del")) decreases a(GO:synapse) |
| pubmed:23702978 | tloc(p(HGNC:CYCS), fromLoc(MESH:Mitochondria), toLoc(MESH:Cytosol)) increases complex(p(HGNC:APAF1), p(HGNC:CYCS)) |
| pubmed:23702978 | tloc(p(HGNC:CYCS), fromLoc(MESH:Mitochondria), toLoc(MESH:Cytosol)) increases act(complex(GO:apoptosome)) |
| pubmed:28528849 | p(HGNC:DBN1) increases bp(GO:"synapse assembly") |
| pubmed:28528849 | act(complex(GO:"NADPH oxidase complex")) increases a(CHEBI:"reactive oxygen species") |
| pubmed:23528736 | p(HGNC:UBB) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23528736 | p(HGNC:UBC) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23528736 | p(HGNC:UBA52) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23528736 | p(HGNC:RPS27A) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23528736 | p(CONSO:"UBB+1", pmod(go:0016567 ! "protein ubiquitination")) decreases bp(GO:"protein deubiquitination") |
| pubmed:23528736 | p(CONSO:"UBB+1", pmod(go:0016567 ! "protein ubiquitination")) decreases act(p(FPLX:Proteasome)) |
| pubmed:23528736 | p(CONSO:"UBB+1", pmod(go:0016567 ! "protein ubiquitination")) regulates path(HP:Neurodegeneration) |
| pubmed:23528736 | p(CONSO:"UBB+1", pmod(go:0016567 ! "protein ubiquitination")) increases bp(MESH:"Stress, Physiological") |
| pubmed:23528736 | p(CONSO:"UBB+1", pmod(go:0016567 ! "protein ubiquitination")) increases act(p(HGNC:TP53)) |
| pubmed:23528736 | p(HGNCGENEFAMILY:"Ubiquitin like modifier activating enzymes") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23528736 | p(HGNCGENEFAMILY:"Ubiquitin conjugating enzymes E2") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23528736 | p(HGNC:RNF182) association path(MESH:"Neurodegenerative Diseases") |
| pubmed:23528736 | p(HGNC:RNF182) association path(MESH:"Alzheimer Disease") |
| pubmed:23528736 | complex(p(HGNC:HSPA8), p(HGNC:STUB1), p(HGNC:UBE2D2)) increases deg(p(HGNC:MAPT)) |
| pubmed:14612456 | p(HGNC:UBE2D2) positiveCorrelation p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:14612456 | p(HGNC:UBE2D2) isA complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:STUB1), p(HGNC:UBE2D2)) |
| pubmed:23528736 | p(HGNC:BCL2L11, pmod(go:0006468 ! "protein phosphorylation")) increases bp(GO:autophagy) |
| pubmed:23528736 | path(HP:"Neurofibrillary tangles") decreases act(p(FPLX:Proteasome)) |
| pubmed:23528736 | p(HGNC:DCTN4) decreases a(CONSO:"Tau aggregates") |
| pubmed:30108137 | act(p(MGI:Tfeb)) association path(MESH:Tauopathies) |
| pubmed:30108137 | p(MGI:Tfeb) decreases path(MESH:Tauopathies) |
| pubmed:30108137 | p(MGI:Tfeb) increases p(MGI:Lamp1) |
| pubmed:30108137 | p(MGI:Tfeb) increases p(MGI:Ctsa) |
| pubmed:30108137 | p(MGI:Tfeb) increases p(MGI:Ctsb) |
| pubmed:30108137 | p(MGI:Tfeb) regulates act(a(MESH:Lysosomes)) |
| pubmed:30108137 | p(MGI:Tfeb) increases act(a(MESH:Phagocytes)) |
| pubmed:30108137 | p(MGI:Tfeb) increases tloc(a(CONSO:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:30108137 | p(MGI:Tfeb) increases tloc(a(CONSO:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:30108137 | p(MGI:Tfeb) increases tloc(a(CONSO:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:30108137 | p(MGI:Tfeb) increases a(CONSO:"Tau fibrils", loc(GO:lysosome)) |
| pubmed:30108137 | p(MGI:Tfeb) increases p(MGI:Tfeb, loc(GO:nucleus)) |
| pubmed:30108137 | p(MGI:Tfeb, loc(GO:nucleus)) increases act(p(MGI:Tfeb)) |
| pubmed:30108137 | p(MGI:Tfeb) increases bp(MESH:Phagocytosis) |
| pubmed:30108137 | p(MGI:Tfeb) increases r(MGI:Lamp1) |
| pubmed:30108137 | p(MGI:Tfeb) increases bp(MESH:Proteolysis) |
| pubmed:30108137 | p(MGI:Tfeb) causesNoChange p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:30108137 | p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:30108137 | p(MGI:Tfeb) causesNoChange p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:30108137 | p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:30108137 | p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:30108137 | p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 199), pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Ser, 208)) |
| pubmed:30108137 | p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:30108137 | p(MGI:Tfeb) causesNoChange p(MGI:Mapt) |
| pubmed:30108137 | p(MGI:Tfeb) decreases p(MGI:Mapt) |
| pubmed:30108137 | p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30108137 | p(MGI:Tfeb) decreases path(MESH:Gliosis) |
| pubmed:30108137 | p(MGI:Tfeb) decreases a(GO:"neurofibrillary tangle") |
| pubmed:30108137 | composite(a(CHEBI:"torin 1"), p(MGI:Tfeb)) increases tloc(a(CONSO:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:28877763 | p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) association p(HGNC:SYK, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29221819 | p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation p(MGI:Dyrk1a) |
| pubmed:25331948 | p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation p(MGI:Syk) |
| pubmed:25887395 | p(HGNC:MAPT, frag("243_375")) increases a(CONSO:"Tau fibrils") |
| pubmed:25887395 | complex(a(CONSO:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) increases tloc(a(CONSO:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:25887395 | complex(a(CONSO:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) increases a(CONSO:"Tau aggregates") |
| pubmed:29980653 | p(HGNCGENEFAMILY:Syndecans) increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29980653 | p(HGNCGENEFAMILY:Syndecans) increases tloc(p(HGNC:SNCA), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29980653 | p(HGNCGENEFAMILY:Syndecans) association a(MESH:Glycosaminoglycans) |
| pubmed:29980653 | p(HGNCGENEFAMILY:Syndecans) increases tloc(a(CONSO:"alpha-synuclein fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:25887395 | a(CHEBI:"sodium chlorate") decreases complex(a(CONSO:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) |
| pubmed:25887395 | a(CHEBI:"sodium chlorate") decreases p(HGNCGENEFAMILY:Syndecans, pmod(go:0006477 ! "protein sulfation")) |
| pubmed:25887395 | a(CHEBI:"sodium chlorate") decreases a(CONSO:"Tau aggregates") |
| pubmed:29980653 | p(HGNCGENEFAMILY:Syndecans, pmod(go:0006477 ! "protein sulfation")) increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:25887395 | complex(p(HGNC:MAPT, frag("243_375")), p(HGNC:MAPT, frag("243_375")), p(HGNC:MAPT, frag("243_375"))) increases a(CONSO:"Tau aggregates") |
| pubmed:25887395 | complex(p(HGNC:MAPT, frag("243_375")), p(HGNC:MAPT, frag("243_375")), p(HGNC:MAPT, frag("243_375"))) increases tloc(a(CONSO:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pubmed:29988016 | p(HGNC:MAPT, var("p.Cys299Ala"), var("p.Cys322Ala")) decreases complex(p(HGNC:MAPT, var("p.Cys299Ala"), var("p.Cys322Ala")), p(HGNC:MAPT, var("p.Cys299Ala"), var("p.Cys322Ala"))) |
| pubmed:29988016 | a(PUBCHEM:100984821) increases a(CONSO:"Tau aggregates") |
| pubmed:21882945 | a(PUBCHEM:134222899) positiveCorrelation bp(GO:cognition) |
| pubmed:21882945 | a(CHEBI:rhodanine) increases a(CONSO:"Tau aggregates") |
| pubmed:26751493 | a(CHEBI:rhodanine) decreases p(CONSO:"Tau aggregates") |
| pubmed:21882945 | a(CONSO:Phenylthiazolyl-hydrazide) decreases a(CONSO:"Tau aggregates") |
| pubmed:29191965 | a(CONSO:Phenylthiazolyl-hydrazide) decreases a(CONSO:"Tau aggregates") |
| pubmed:29191965 | a(CONSO:Phenylthiazolyl-hydrazide) increases bp(GO:locomotion) |
| pubmed:21882945 | a(PUBCHEM:53789478) decreases a(CONSO:"Tau aggregates") |
| pubmed:21882945 | a(CHEBI:anthraquinone) decreases a(CONSO:"Tau aggregates") |
| pubmed:21882945 | a(CHEBI:benzothiazoles) decreases a(CONSO:"Tau aggregates") |
| pubmed:21882945 | p(INTERPRO:"Chaperone J-domain superfamily") increases act(p(INTERPRO:"Heat shock protein 70 family")) |
| pubmed:21882945 | p(INTERPRO:"Chaperone J-domain superfamily") increases rxn(reactants(a(CHEBI:ATP)), products(a(CHEBI:"phosphate(3-)"), a(CHEBI:ADP))) |
| pubmed:21882945 | a(MESH:"Guanine Nucleotide Exchange Factors") increases act(p(INTERPRO:"Heat shock protein 70 family")) |
| pubmed:21882945 | a(MESH:"Guanine Nucleotide Exchange Factors") increases a(CHEBI:ADP) |
| pubmed:21882945 | a(PUBCHEM:25195348) decreases act(a(MESH:"Adenosine Triphosphatases")) |
| pubmed:21882945 | a(PUBCHEM:1056) decreases act(p(INTERPRO:"Heat shock protein 70 family")) |
| pubmed:21882945 | a(PUBCHEM:1056) regulates complex(p(INTERPRO:"Chaperone J-domain superfamily"), p(INTERPRO:"Heat shock protein 70 family")) |
| pubmed:21882945 | a(PUBCHEM:6444403) decreases act(p(INTERPRO:"Heat shock protein 70 family")) |
| pubmed:21882945 | complex(p(FPLX:HSP90), p(FPLX:HSP90)) increases act(p(FPLX:HSP90)) |
| pubmed:21882945 | p(INTERPRO:"Tetratricopeptide repeat-containing domain") regulates act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pubmed:21882945 | a(PUBCHEM:6505803) directlyIncreases complex(a(PUBCHEM:9549213), p(INTERPRO:"Heat shock protein Hsp90, N-terminal")) |
| pubmed:21882945 | a(PUBCHEM:6505803) directlyDecreases act(p(FPLX:HSP90)) |
| pubmed:21882945 | a(PUBCHEM:6505803) decreases path(MESH:Neoplasms) |
| pubmed:21882945 | a(PUBCHEM:9549213) directlyIncreases complex(a(PUBCHEM:9549213), p(INTERPRO:"Heat shock protein Hsp90, N-terminal")) |
| pubmed:21882945 | a(PUBCHEM:9549213) directlyDecreases act(p(FPLX:HSP90)) |
| pubmed:21882945 | a(PUBCHEM:9549213) decreases path(MESH:Neoplasms) |
| pubmed:21882945 | a(CHEBI:novobiocin) directlyIncreases complex(a(CHEBI:novobiocin), p(INTERPRO:"HSP90, C-terminal domain")) |
| pubmed:21882945 | a(CHEBI:novobiocin) directlyDecreases act(p(FPLX:HSP90)) |
| pubmed:21882945 | a(CHEBI:novobiocin) decreases path(MESH:Neoplasms) |
| pubmed:21882945 | a(PUBCHEM:501026) directlyIncreases complex(a(PUBCHEM:501026), p(INTERPRO:"HSP90, C-terminal domain")) |
| pubmed:21882945 | a(PUBCHEM:501026) directlyDecreases act(p(FPLX:HSP90)) |
| pubmed:21882945 | a(PUBCHEM:501026) decreases path(MESH:Neoplasms) |
| pubmed:21882945 | a(CHEBI:celastrol) association act(p(FPLX:HSP90)) |
| pubmed:29311797 | a(CHEBI:celastrol) decreases act(p(FPLX:HSP90)) |
| pubmed:29311797 | a(CHEBI:celastrol) decreases act(p(HGNC:CDC37)) |
| pubmed:29311797 | a(CHEBI:celastrol) decreases p(HGNC:MAPT) |
| pubmed:21882945 | complex(p(FPLX:HSP90), p(HGNC:STUB1)) association p(HGNC:AKT1) |
| pubmed:25374103 | complex(p(FPLX:HSP90), p(HGNC:STUB1)) increases complex(p(FPLX:HSP90), p(HGNC:STUB1), p(MESH:Proteins, pmod(CONSO:misfolded))) |
| pubmed:21882945 | complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) |
| pubmed:21882945 | complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:14963027 | complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases rxn(reactants(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) |
| pubmed:14963027 | complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) |
| pubmed:21882945 | complex(p(HGNC:BAG1), p(INTERPRO:"Heat shock protein 70 family")) increases p(HGNC:MAPT) |
| pubmed:20071522 | complex(p(FPLX:HSP90), p(HGNC:MAPT)) positiveCorrelation p(HGNC:FKBP5) |
| pubmed:20071522 | complex(p(HGNC:FKBP5), p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:20071522 | complex(p(HGNC:FKBP5), p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:20071522 | complex(p(HGNC:FKBP5), p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:21882945 | complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases complex(a(MESH:"Protein Phosphatase 2"), p(HGNC:MAPT)) |
| pubmed:21882945 | complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) |
| pubmed:21882945 | complex(p(FPLX:HSP90), p(HGNC:FKBP5)) causesNoChange p(HGNC:MAPT) |
| pubmed:29311797 | complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases a(CONSO:"Tau oligomers") |
| pubmed:21882945 | complex(a(MESH:"Protein Phosphatase 2"), p(HGNC:MAPT)) increases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:21882945 | complex(a(MESH:Proteins), p(INTERPRO:"Heat shock protein 70 family")) positiveCorrelation complex(a(MESH:Proteins), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) |
| pubmed:21882945 | complex(a(MESH:Proteins), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) positiveCorrelation complex(a(MESH:Proteins), p(INTERPRO:"Heat shock protein 70 family")) |
| pubmed:21882945 | complex(a(MESH:Proteins), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) increases bp(GO:"protein polyubiquitination") |
| pubmed:21882945 | complex(a(MESH:Proteins), p(FPLX:HSP90)) increases deg(a(MESH:Proteins)) |
| pubmed:21882945 | complex(p(HGNC:VHL), p(INTERPRO:"Heat shock protein 70 family")) increases deg(p(HGNC:VHL)) |
| pubmed:21882945 | complex(p(FPLX:HSP90), p(HGNC:VHL)) increases deg(p(HGNC:VHL)) |
| pubmed:21882945 | complex(p(HGNC:STIP1), p(HGNC:VHL)) increases deg(p(HGNC:VHL)) |
| pubmed:30126037 | p(MGI:Cdkn2a) association bp(GO:"cellular senescence") |
| pubmed:30126037 | p(MGI:Cdkn2a) positiveCorrelation path(HP:"Cerebral atrophy") |
| pubmed:30126037 | p(MGI:Cdkn2a) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pubmed:30126037 | p(MGI:Cdkn2a) positiveCorrelation path(HP:"Brain atrophy") |
| pubmed:30126037 | path(HP:"Cerebral atrophy") positiveCorrelation p(MGI:Cdkn2a) |
| pubmed:30126037 | path(MESH:"Hypertrophy, Right Ventricular") association a(GO:"neurofibrillary tangle") |
| pubmed:30126037 | path(MESH:"Hypertrophy, Left Ventricular") association a(GO:"neurofibrillary tangle") |
| pubmed:30126037 | p(MGI:H2afx) biomarkerFor bp(MESH:"DNA Breaks, Double-Stranded") |
| pubmed:30126037 | p(MGI:H2afx) biomarkerFor bp(GO:"cellular senescence") |
| pubmed:30126037 | p(MGI:Glb1) positiveCorrelation a(HP:brain) |
| pubmed:30126037 | a(HP:brain) positiveCorrelation p(MGI:Glb1) |
| pubmed:30126037 | path(HP:"Brain atrophy") positiveCorrelation p(MGI:Cdkn2a) |
| pubmed:30126037 | path(HP:"Brain atrophy") association a(GO:"neurofibrillary tangle") |
| pubmed:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle") |
| pubmed:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle") |
| pubmed:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle") |
| pubmed:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(GO:"cellular senescence") |
| pubmed:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(GO:"cellular senescence") |
| pubmed:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"Brain atrophy") |
| pubmed:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"cardiac ventricle") |
| pubmed:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"Hyperintensity of cerebral white matter on MRI") |
| pubmed:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(MESH:"Cerebrovascular Circulation") |
| pubmed:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Syp) |
| pubmed:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Rbfox3) |
| pubmed:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Dlg4) |
| pubmed:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Aif1) |
| pubmed:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases bp(MESH:Neuroprotection) |
| pubmed:30126037 | path(MESH:"Cerebral Small Vessel Diseases") increases path(HP:"Hyperintensity of cerebral white matter on MRI") |
| pubmed:30126037 | path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:Ischemia) |
| pubmed:30126037 | path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:"Cognitive Dysfunction") |
| pubmed:30126037 | path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:Dementia) |
| pubmed:28173111 | p(MGI:Dlg4) negativeCorrelation p(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Dlg4) association act(complex(GO:"neuron to neuron synapse")) |
| pubmed:28408124 | a(CONSO:"Tau antibody, Tau-13") decreases p(MGI:Mapt, loc(GO:cell)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, Tau-13") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, Tau-13") decreases p(HGNC:MAPT, loc(GO:cell)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, Tau-13") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, 6C5") decreases p(MGI:Mapt, loc(GO:cell)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, 6C5") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, 6C5") decreases p(HGNC:MAPT, loc(GO:cell)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, 6C5") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, 6C5") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, 6C5") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, 6C5") decreases a(GO:"neurofibrillary tangle") |
| pubmed:28408124 | a(CONSO:"Tau antibody, 6C5") decreases path(MESH:"Plaque, Amyloid") |
| pubmed:28408124 | a(CONSO:"Tau antibody, 40E8") decreases p(MGI:Mapt, loc(GO:cell)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, 40E8") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, 40E8") decreases p(HGNC:MAPT, loc(GO:cell)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, 40E8") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, 40E8") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, 40E8") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28408124 | a(CONSO:"Tau antibody, 40E8") decreases a(GO:"neurofibrillary tangle") |
| pubmed:28408124 | a(CONSO:"Tau antibody, 40E8") decreases path(MESH:"Plaque, Amyloid") |
| pubmed:28408124 | a(CONSO:"Tau antibody, 40E8") decreases a(MESH:"Neuropil Threads") |
| pubmed:28408124 | a(CONSO:"Tau antibody, pS396") decreases p(MGI:Mapt, loc(GO:cell)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, pS396") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, pS396") decreases p(HGNC:MAPT, loc(GO:cell)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, pS396") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, pS396") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28408124 | a(CONSO:"Tau antibody, 4E4") decreases p(MGI:Mapt, loc(GO:cell)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, 4E4") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, 4E4") decreases p(HGNC:MAPT, loc(GO:cell)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, 4E4") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, Tau46") decreases p(MGI:Mapt, loc(GO:cell)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, Tau46") causesNoChange tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, Tau46") decreases p(HGNC:MAPT, loc(GO:cell)) |
| pubmed:28408124 | a(CONSO:"Tau antibody, Tau46") causesNoChange tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:25995053 | p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases a(GO:"dendritic spine") |
| pubmed:28877763 | p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) positiveCorrelation p(MGI:Syk) |
| pubmed:25331948 | p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) positiveCorrelation p(MGI:Syk) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases a(CHEBI:amyloid-beta) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases a(CHEBI:amyloid-beta) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases a(CHEBI:amyloid-beta) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases a(CHEBI:amyloid-beta) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) increases tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:Brain), toLoc(MESH:Blood)) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases act(p(HGNC:APP)) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases r(HGNC:BACE1) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases r(HGNC:BACE1) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases r(HGNC:BACE1) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases p(HGNC:BACE1) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases p(HGNC:BACE1) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:25331948 | a(CHEBI:Nilvadipine) increases tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(MESH:Brain), toLoc(MESH:Plasma)) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) increases bp(GO:"amyloid-beta clearance by transcytosis") |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases p(HGNC:RAF1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases act(p(HGNC:SYK)) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) increases complex(a(CHEBI:Nilvadipine), p(HGNC:SYK)) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) increases complex(a(CHEBI:Nilvadipine), p(HGNC:SYK)) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases act(complex(GO:"NF-kappaB complex")) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) directlyDecreases complex(GO:"L-type voltage-gated calcium channel complex") |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:25331948 | a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:28877763 | p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) positiveCorrelation p(MGI:Syk) |
| pubmed:25331948 | p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) positiveCorrelation p(MGI:Syk) |
| pubmed:25331948 | composite(a(CHEBI:Nilvadipine), p(HGNC:TNF)) decreases act(complex(GO:"NF-kappaB complex")) |
| pubmed:25331948 | composite(a(CHEBI:"phorbol 13-acetate 12-myristate"), a(CHEBI:Nilvadipine)) decreases act(complex(GO:"NF-kappaB complex")) |
| pubmed:25331948 | a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(p(FPLX:PKC)) |
| pubmed:25331948 | a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:25331948 | a(CHEBI:"phorbol 13-acetate 12-myristate") increases p(HGNC:RAF1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25331948 | a(CHEBI:"phorbol 13-acetate 12-myristate") increases p(HGNC:RAF1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25331948 | a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(p(HGNC:SYK)) |
| pubmed:25331948 | a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(p(HGNC:BTK)) |
| pubmed:25331948 | composite(p(FPLX:RHO), p(HGNC:ROCK1)) increases act(p(HGNC:TNF)) |
| pubmed:25331948 | composite(p(FPLX:RHO), p(HGNC:ROCK1)) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:25331948 | act(p(HGNC:SYK)) regulates act(complex(GO:"NF-kappaB complex")) |
| pubmed:25331948 | p(HGNC:SYK) increases act(complex(GO:"NF-kappaB complex")) |
| pubmed:25331948 | p(HGNC:SYK) regulates act(complex(GO:"NF-kappaB complex")) |
| pubmed:25331948 | p(HGNC:SYK) increases a(CHEBI:amyloid-beta) |
| pubmed:25331948 | act(p(HGNC:SYK)) increases a(CHEBI:amyloid-beta) |
| pubmed:25331948 | act(p(HGNC:SYK)) decreases tloc(a(CHEBI:amyloid-beta), fromLoc(GO:intracellular), toLoc(MESH:Plasma)) |
| pubmed:25331948 | act(p(HGNC:SYK)) increases tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28877763 | p(HGNC:SYK) regulates p(CONSO:sAPP-beta) |
| pubmed:25331948 | act(p(HGNC:SYK)) increases r(HGNC:BACE1) |
| pubmed:25331948 | act(p(HGNC:SYK)) increases p(HGNC:BACE1) |
| pubmed:28877763 | p(HGNC:SYK) regulates p(HGNC:BACE1) |
| pubmed:25331948 | act(p(HGNC:SYK)) increases p(HGNC:RAF1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25331948 | p(HGNC:SYK) regulates p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) |
| pubmed:28877763 | act(p(HGNC:SYK), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) |
| pubmed:28877763 | act(p(HGNC:SYK)) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) |
| pubmed:28877763 | p(HGNC:SYK) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) |
| pubmed:28877763 | act(p(HGNC:SYK)) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) |
| pubmed:26631930 | p(HGNC:SYK) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) |
| pubmed:25331948 | act(p(HGNC:SYK)) increases act(p(HGNC:GSK3B)) |
| pubmed:28877763 | p(HGNC:SYK) increases act(p(HGNC:GSK3B)) |
| pubmed:25331948 | act(p(HGNC:SYK)) increases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:25331948 | p(HGNC:SYK) decreases act(p(FPLX:PKA)) |
| pubmed:25331948 | p(HGNC:SYK) decreases act(p(FPLX:PKA)) |
| pubmed:25331948 | p(HGNC:SYK) increases p(FPLX:PKA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 330)) |
| pubmed:29191965 | p(HGNC:SYK) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr)) |
| pubmed:28877763 | act(p(HGNC:SYK)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:28877763 | p(HGNC:SYK) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:28877763 | act(p(HGNC:SYK)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:28877763 | act(p(HGNC:SYK)) increases p(HGNC:MAPT, pmod(CONSO:misfolded)) |
| pubmed:28877763 | act(p(HGNC:SYK)) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:misfolded)) |
| pubmed:28877763 | p(HGNC:SYK) increases p(HGNC:MAPT) |
| pubmed:28877763 | p(HGNC:SYK) regulates deg(p(HGNC:MAPT)) |
| pubmed:28877763 | p(HGNC:SYK) causesNoChange r(HGNC:MAPT) |
| pubmed:28877763 | act(p(HGNC:SYK)) positiveCorrelation a(CONSO:"amyloid-beta aggregates") |
| pubmed:28877763 | p(HGNC:SYK) increases a(CONSO:"Tau aggregates") |
| pubmed:28877763 | p(HGNC:SYK) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:26501932 | p(HGNC:SYK) partOf a(CONSO:pretangles) |
| pubmed:26501932 | p(HGNC:SYK) partOf a(CONSO:"GVD bodies") |
| pubmed:25331948 | act(p(HGNC:SYK)) decreases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:23702978 | act(p(HGNC:SYK)) increases complex(p(HGNC:CASP8), p(HGNC:MALT1)) |
| pubmed:10887109 | act(p(HGNC:SYK), ma(go:0016301 ! "kinase activity")) causesNoChange p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25331948 | act(p(HGNC:BTK)) regulates act(complex(GO:"NF-kappaB complex")) |
| pubmed:25331948 | a(PUBCHEM:71656932) decreases act(p(HGNC:BTK)) |
| pubmed:25331948 | a(PUBCHEM:71656932) causesNoChange a(CHEBI:amyloid-beta) |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases act(p(HGNC:SYK)) |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases act(p(HGNC:SYK)) |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases act(complex(GO:"NF-kappaB complex")) |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases a(CHEBI:amyloid-beta) |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases tloc(a(CHEBI:amyloid-beta), fromLoc(GO:intracellular), toLoc(MESH:Plasma)) |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases r(HGNC:BACE1) |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:BACE1) |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:App, frag("1_38")) |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:intracellular), toLoc(MESH:Plasma)) |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") causesNoChange p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Tyr, 231)) |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 231)) |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation", Ser, 473)) |
| pubmed:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases p(HGNC:CREB1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28877763 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) positiveCorrelation p(HGNC:SYK, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28877763 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) positiveCorrelation p(HGNC:SYK, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28877763 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) increases act(p(HGNC:SYK)) |
| pubmed:28877763 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) positiveCorrelation act(p(HGNC:SYK)) |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) association a(CONSO:"paired helical filaments") |
| pubmed:16566606 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) positiveCorrelation a(GO:microtubule) |
| pubmed:28877763 | p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) positiveCorrelation p(MGI:Syk) |
| pubmed:25331948 | p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) positiveCorrelation p(MGI:Syk) |
| pubmed:25331948 | p(FPLX:PKA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 330)) decreases act(p(FPLX:PKA)) |
| pubmed:22419736 | p(HGNC:AK1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22419736 | p(HGNC:AK1) increases act(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pubmed:22419736 | p(HGNC:AK1) increases p(CONSO:"Tau aggregates") |
| pubmed:22419736 | p(HGNC:AK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22419736 | p(HGNC:AK1) negativeCorrelation p(FPLX:AMPK, pmod(go:0006468 ! "protein phosphorylation", Thr, 172)) |
| pubmed:22419736 | p(HGNC:AK1) decreases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:22419736 | p(HGNC:AK1) regulates act(p(HGNC:GSK3B)) |
| pubmed:22419736 | p(HGNC:AK1) regulates act(p(HGNC:GSK3B)) |
| pubmed:22419736 | p(HGNC:AK1) regulates act(p(FPLX:AMPK)) |
| pubmed:22419736 | p(HGNC:AK1) increases act(p(HGNC:MAPT)) |
| pubmed:22419736 | p(HGNC:AK1) increases path(MESH:"Retinal Degeneration") |
| pubmed:22419736 | p(HGNC:AK1) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:22419736 | p(MGI:App, var("c.27269938A>C"), var("c.27269939G>T")) positiveCorrelation p(MGI:Ak1) |
| pubmed:22419736 | p(MGI:Ak1) positiveCorrelation p(MGI:App, var("c.27269938A>C"), var("c.27269939G>T")) |
| pubmed:22419736 | p(MGI:Ak1) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:22419736 | p(MGI:Ak1) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:22419736 | p(MGI:Ak1) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:22419736 | p(MGI:Ak1) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 231)) |
| pubmed:22419736 | p(MGI:Ak1) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 235)) |
| pubmed:22419736 | p(MESH:"Acetyl-CoA Carboxylase") association act(p(FPLX:AMPK)) |
| pubmed:22419736 | p(HGNC:AK1, var("p.Arg132Ala")) causesNoChange p(FPLX:AMPK, pmod(go:0006468 ! "protein phosphorylation", Thr, 172)) |
| pubmed:22419736 | p(HGNC:AK1, var("p.Arg132Ala")) causesNoChange p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:22419736 | a(CHEBI:dorsomorphin) decreases act(p(FPLX:AMPK)) |
| pubmed:22419736 | a(CHEBI:dorsomorphin) decreases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:22419736 | a(CHEBI:dorsomorphin) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:22419736 | a(CHEBI:dorsomorphin) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:22419736 | composite(p(HGNC:AK1), p(HGNC:MAPT)) increases path(MESH:"Retinal Degeneration") |
| pubmed:22419736 | path(MESH:"Retinal Degeneration") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30640040 | act(p(FPLX:TGFB)) increases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:9804992) decreases act(p(FPLX:HDAC)) |
| pubmed:30640040 | a(PUBCHEM:9804992) increases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:9865515) increases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:9865515) association p(FPLX:HDAC) |
| pubmed:30640040 | a(PUBCHEM:24756910) increases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:24756910) association p(FPLX:"HDAC_I") |
| pubmed:30640040 | a(PUBCHEM:24756910) association p(FPLX:"HDAC_II") |
| pubmed:30640040 | a(PUBCHEM:24756910) association p(HGNC:EGFR) |
| pubmed:30640040 | a(PUBCHEM:24756910) association p(HGNC:ERBB2) |
| pubmed:30640040 | a(PUBCHEM:448537) increases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:448537) association p(FPLX:ESR) |
| pubmed:30640040 | a(PUBCHEM:5318517) increases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:5318517) association p(FPLX:NFkappaB) |
| pubmed:30640040 | a(PUBCHEM:5318517) association p(FPLX:Actin) |
| pubmed:30640040 | a(PUBCHEM:71295844) increases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:71295844) association p(HGNC:GSK3A) |
| pubmed:30640040 | a(PUBCHEM:71295844) association p(HGNC:GSK3B) |
| pubmed:30640040 | a(PUBCHEM:42640) increases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:42640) association p(HGNC:MDM4) |
| pubmed:30640040 | a(PUBCHEM:2746) increases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:2746) association p(FPLX:"HDAC_I") |
| pubmed:30640040 | a(PUBCHEM:71729974) increases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:71729974) association p(HGNCGENEFAMILY:"Lysine demethylases") |
| pubmed:30640040 | a(PUBCHEM:11154925) decreases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:11154925) association p(HGNC:KDR) |
| pubmed:30640040 | a(PUBCHEM:4521392) decreases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:4521392) association p(HGNC:TGFBR1) |
| pubmed:30640040 | a(PUBCHEM:11234052) decreases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:11234052) association p(HGNC:KDR) |
| pubmed:30640040 | a(PUBCHEM:46209426) decreases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:46209426) association p(FPLX:ROCK) |
| pubmed:30640040 | a(PUBCHEM:6321424) decreases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:6321424) increases act(p(HGNCGENEFAMILY:"Chloride channel accessory")) |
| pubmed:30640040 | a(PUBCHEM:11570805) decreases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:11570805) association p(HGNC:MAPK14) |
| pubmed:30640040 | a(PUBCHEM:156422) decreases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:156422) association p(HGNC:MAPK14) |
| pubmed:30640040 | a(PUBCHEM:9880) decreases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:9880) decreases act(p(HGNC:AR)) |
| pubmed:30640040 | a(PUBCHEM:3033825) decreases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:3033825) association p(HGNC:TNC) |
| pubmed:30640040 | a(PUBCHEM:5311272) decreases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:5311272) decreases act(p(FPLX:"Gamma_secretase")) |
| pubmed:30640040 | a(PUBCHEM:49806720) decreases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:49806720) decreases act(p(HGNC:ALK)) |
| pubmed:30640040 | a(PUBCHEM:9839311) decreases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:9839311) association p(HGNC:SELE) |
| pubmed:30640040 | a(PUBCHEM:9839311) association p(HGNC:ICAM1) |
| pubmed:30640040 | a(PUBCHEM:447966) decreases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:447966) association p(HGNC:TGFBR1) |
| pubmed:30640040 | a(PUBCHEM:11655119) decreases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:11655119) association p(HGNC:TGFBR1) |
| pubmed:30640040 | a(PUBCHEM:11655119) association p(HGNC:TGFBR2) |
| pubmed:30640040 | a(PUBCHEM:10435235) decreases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:10435235) decreases act(p(FPLX:"Gamma_secretase")) |
| pubmed:30640040 | a(PUBCHEM:5833) decreases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:5833) association p(HGNC:AR) |
| pubmed:30640040 | a(PUBCHEM:10341154) decreases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:10341154) association p(HGNC:MAPK14) |
| pubmed:30640040 | a(PUBCHEM:4878) decreases a(CONSO:"Tau aggregates") |
| pubmed:30640040 | a(PUBCHEM:4878) association p(HGNC:LCK) |
| pubmed:30640040 | a(PUBCHEM:4878) association p(HGNC:FYN) |
| pubmed:30640040 | p(FPLX:"HDAC_I") association a(PUBCHEM:24756910) |
| pubmed:30640040 | p(FPLX:"HDAC_I") association a(PUBCHEM:2746) |
| pubmed:30640040 | p(FPLX:"HDAC_II") association a(PUBCHEM:24756910) |
| pubmed:30640040 | p(HGNC:ERBB2) association a(PUBCHEM:24756910) |
| pubmed:30640040 | p(FPLX:ESR) association a(PUBCHEM:448537) |
| pubmed:30640040 | p(FPLX:Actin) association a(PUBCHEM:5318517) |
| pubmed:30640040 | p(HGNC:MDM4) association a(PUBCHEM:42640) |
| pubmed:30640040 | p(HGNCGENEFAMILY:"Lysine demethylases") association a(PUBCHEM:71729974) |
| pubmed:30640040 | p(HGNC:TGFBR1) association a(PUBCHEM:4521392) |
| pubmed:30640040 | p(HGNC:TGFBR1) association a(PUBCHEM:447966) |
| pubmed:30640040 | p(HGNC:TGFBR1) association a(PUBCHEM:11655119) |
| pubmed:30640040 | p(FPLX:ROCK) association a(PUBCHEM:46209426) |
| pubmed:30640040 | p(HGNC:TNC) association a(PUBCHEM:3033825) |
| pubmed:30640040 | p(HGNC:TGFBR2) association a(PUBCHEM:11655119) |
| pubmed:29191965 | composite(a(MESH:"Amyloid beta-Peptides"), a(PUBCHEM:160718443)) decreases path(MESH:Paralysis) |
| pubmed:29191965 | bp(GO:"cellular response to mechanical stimulus") decreases a(GO:"microtubule cytoskeleton") |
| pubmed:29191965 | composite(p(HGNC:MAPT), p(HGNC:SPTB)) increases a(GO:"microtubule cytoskeleton") |
| pubmed:29191965 | composite(p(HGNC:KLC3), p(HGNC:MAPT)) increases complex(p(HGNC:KLC3), p(HGNC:MAPT)) |
| pubmed:29191965 | complex(p(HGNC:KLC3), p(HGNC:MAPT)) association a(GO:"synaptic vesicle") |
| pubmed:29191965 | p(CONSO:"Tau isoform E (412 aa)", var("p.Pro301Leu")) decreases bp(GO:locomotion) |
| pubmed:29191965 | p(CONSO:"Tau isoform E (412 aa)", var("p.Pro301Leu")) decreases a(MESH:Survival) |
| pubmed:29191965 | p(CONSO:"Tau isoform E (412 aa)", var("p.Pro301Leu")) increases path(CONSO:Neurodegeneration) |
| pubmed:29191965 | p(CONSO:"Tau isoform E (412 aa)", var("p.Pro301Leu")) increases a(CONSO:"Tau aggregates") |
| pubmed:29191965 | p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")) decreases bp(GO:locomotion) |
| pubmed:29191965 | p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")) decreases a(MESH:Survival) |
| pubmed:29191965 | p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")) increases path(CONSO:Neurodegeneration) |
| pubmed:29191965 | p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) decreases act(a(MESH:Neurons)) |
| pubmed:29191965 | p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) decreases act(a(MESH:Neurons)) |
| pubmed:29191965 | p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) decreases a(GO:microtubule) |
| pubmed:29191965 | p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) increases bp(GO:"neuron death") |
| pubmed:26458742 | p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:26458742 | p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:26458742 | p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation", Ser, 400)) |
| pubmed:26458742 | p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:26458742 | p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation", Ser, 409)) |
| pubmed:26458742 | p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:26458742 | p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) increases a(CONSO:"Tau aggregates") |
| pubmed:29191965 | p(CONSO:"Tau isoform D (383 aa)", var("p.Arg406Trp")) decreases act(a(MESH:Neurons)) |
| pubmed:29191965 | p(CONSO:"Tau isoform D (383 aa)", var("p.Arg406Trp")) decreases act(a(MESH:Neurons)) |
| pubmed:29191965 | p(CONSO:"Tau isoform D (383 aa)", var("p.Arg406Trp")) decreases a(GO:microtubule) |
| pubmed:29191965 | p(CONSO:"Tau isoform D (383 aa)", var("p.Arg406Trp")) increases bp(GO:"neuron death") |
| pubmed:29191965 | p(CONSO:"Tau isoform Fetal-tau (352 aa)", pmod(CONSO:hyperphosphorylation)) decreases bp(GO:locomotion) |
| pubmed:29191965 | p(CONSO:"Tau isoform Fetal-tau (352 aa)", pmod(CONSO:hyperphosphorylation)) decreases a(MESH:"Motor Neurons") |
| pubmed:29191965 | composite(p(CONSO:"4R tau", var("p.Lys280del")), p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met"))) increases path(MESH:Paralysis) |
| pubmed:29191965 | composite(p(CONSO:"4R tau", var("p.Lys280del")), p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases a(MESH:"GABAergic Neurons") |
| pubmed:29191965 | composite(p(CONSO:"4R tau", var("p.Lys280del")), p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases a(MESH:"Cholinergic Neurons") |
| pubmed:29191965 | composite(p(CONSO:"4R tau", var("p.Lys280del")), p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases a(GO:synapse) |
| pubmed:29191965 | composite(p(CONSO:"4R tau", var("p.Lys280del")), p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases bp(GO:"axonal transport of mitochondrion") |
| pubmed:25374103 | p(CONSO:"4R tau", var("p.Lys280del")) causesNoChange bp(GO:"cell death") |
| pubmed:25374103 | p(CONSO:"4R tau", var("p.Lys280del")) decreases bp(GO:"mitochondrion transport along microtubule") |
| pubmed:25374103 | p(CONSO:"4R tau", var("p.Lys280del")) decreases bp(GO:"mitochondrion transport along microtubule") |
| pubmed:29191965 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ala152Thr")) increases path(MESH:Paralysis) |
| pubmed:29191965 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ala152Thr")) decreases act(a(MESH:Neurons)) |
| pubmed:29191965 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ala152Thr")) association bp(GO:"cell aging") |
| pubmed:29191965 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ala152Thr")) decreases bp(MESH:Longevity) |
| pubmed:29191965 | p(CONSO:"Tau isoform F (441 aa)", var("p.Ala152Thr")) decreases bp(GO:"anterograde axonal transport of mitochondrion") |
| pubmed:29191965 | bp(GO:"cell aging") association p(CONSO:"Tau isoform F (441 aa)", var("p.Ala152Thr")) |
| pubmed:29191965 | complex(a(GO:"synaptic vesicle"), p(HGNC:MAPT)) decreases bp(MESH:"Synaptic Transmission") |
| pubmed:29191965 | complex(a(GO:"synaptic vesicle"), p(HGNC:MAPT)) decreases act(a(GO:"synaptic vesicle")) |
| pubmed:29191965 | composite(p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:CHRNA7)) decreases bp(GO:locomotion) |
| pubmed:29191965 | composite(p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:BAIAP3)) decreases bp(GO:locomotion) |
| pubmed:29191965 | p(HGNC:BAIAP3) regulates bp(GO:"retrograde trans-synaptic signaling") |
| pubmed:30985105 | bp(GO:"musculoskeletal movement") association bp(GO:"dopamine secretion") |
| pubmed:29191965 | a(GO:"cell body") association p(HGNC:MAPT) |
| pubmed:29191965 | p(HGNC:PPP3CB) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26631930 | p(HGNC:PPP3CB) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29191965 | p(HGNC:PPP1R8) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26631930 | p(HGNC:PPP1R8) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29191965 | composite(p(CONSO:"Tau isoform D (383 aa)", var("p.Arg406Trp")), p(HGNC:CDK5)) decreases a(MESH:Neurons) |
| pubmed:29191965 | a(PUBCHEM:6475963) decreases a(CONSO:"Tau aggregates") |
| pubmed:29191965 | a(PUBCHEM:6475963) increases bp(GO:locomotion) |
| pubmed:29191965 | a(PUBCHEM:66766582) decreases path(CONSO:Neurodegeneration) |
| pubmed:29191965 | a(CHEBI:azaperone) increases bp(GO:locomotion) |
| pubmed:29191965 | a(CHEBI:azaperone) decreases p(HGNC:MAPT) |
| pubmed:29191965 | a(CHEBI:azaperone) decreases path(CONSO:Neurodegeneration) |
| pubmed:29191965 | a(CHEBI:ethosuximide) increases bp(MESH:Longevity) |
| pubmed:29191965 | a(CHEBI:ethosuximide) increases bp(GO:locomotion) |
| pubmed:29191965 | a(CHEBI:ethosuximide) association bp(GO:"insulin receptor signaling pathway") |
| pubmed:29191965 | p(HGNC:WNT2) association path(MESH:Tauopathies) |
| pubmed:29191965 | p(HGNC:TTBK2) association path(MESH:Tauopathies) |
| pubmed:17620722 | p(HGNC:TTBK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 208)) |
| pubmed:17620722 | p(HGNC:TTBK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 210)) |
| pubmed:25673844 | p(HGNC:TTBK2) isA p(CONSO:"CK1 superfamily") |
| pubmed:25673844 | p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 42)) |
| pubmed:25673844 | p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 45)) |
| pubmed:25673844 | p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 47)) |
| pubmed:25673844 | p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 80)) |
| pubmed:25673844 | p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 81)) |
| pubmed:25673844 | p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Thr, 84)) |
| pubmed:25473830 | p(HGNC:TTBK2) directlyIncreases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25473830 | p(HGNC:TTBK2) increases tloc(p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation")), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) |
| pubmed:27607061 | p(HGNC:TTBK2) decreases tloc(p(HGNC:GRIK2), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) |
| pubmed:23942339 | p(HGNC:TTBK2) increases act(p(HGNC:SLC6A12)) |
| pubmed:22814243 | p(HGNC:TTBK2) increases act(p(HGNC:SLC5A1)) |
| pubmed:25297623 | p(HGNC:TTBK2) association p(HGNC:CEP164) |
| pubmed:25297623 | p(HGNC:TTBK2) association p(HGNC:MAPRE1) |
| pubmed:25297623 | act(p(HGNC:TTBK2)) increases deg(p(HGNC:CCP110)) |
| pubmed:25297623 | act(p(HGNC:TTBK2)) increases p(HGNC:CEP164, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25297623 | act(p(HGNC:TTBK2)) increases p(HGNC:CEP97, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25297623 | act(p(HGNC:TTBK2)) increases bp(GO:"cytosolic ciliogenesis") |
| pubmed:29191965 | p(HGNC:TAOK1) association path(MESH:Tauopathies) |
| pubmed:25974414 | act(p(HGNC:TAOK1), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:29191965 | p(HGNC:CTSE) association path(MESH:Tauopathies) |
| pubmed:29191965 | p(HGNC:DNMBP) increases complex(p(HGNC:DNMBP), p(HGNC:ENAH)) |
| pubmed:29191965 | composite(p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DNMBP)) increases path(MESH:Tauopathies) |
| pubmed:29191965 | p(HGNC:ZC3H14) decreases bp(GO:locomotion) |
| pubmed:29191965 | p(HGNC:ZC3H14) increases path(CONSO:Neurodegeneration) |
| pubmed:29191965 | p(HGNC:ZC3H14) increases p(HGNC:MAPT) |
| pubmed:29191965 | p(HGNC:ZC3H14) increases path(MESH:Tauopathies) |
| pubmed:29191965 | p(HGNC:ZC3H14) regulates bp(GO:"aggresome assembly") |
| pubmed:29191965 | bp(GO:"aggresome assembly") association path(MESH:"Neurodegenerative Diseases") |
| pubmed:29191965 | bp(GO:"aggresome assembly") decreases p(MESH:Proteins, pmod(CONSO:misfolding)) |
| pubmed:29191965 | p(HGNC:DDC) increases a(CHEBI:dopamine) |
| pubmed:29191965 | p(HGNC:DDC) increases a(CHEBI:serotonin) |
| pubmed:29191965 | composite(p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) decreases bp(GO:locomotion) |
| pubmed:29191965 | composite(p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) increases p(HGNC:MAPT) |
| pubmed:29191965 | composite(p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29191965 | composite(p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) increases path(CONSO:Neurodegeneration) |
| pubmed:29191965 | composite(p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:TH)) causesNoChange path(MESH:Tauopathies) |
| pubmed:29191965 | p(HGNC:GCH1) regulates a(CHEBI:dopamine) |
| pubmed:29191965 | p(HGNC:GCH1) regulates a(CHEBI:serotonin) |
| pubmed:29191965 | p(HGNC:GCH1) regulates act(p(HGNC:DDC)) |
| pubmed:29191965 | composite(p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:GCH1)) causesNoChange path(MESH:Tauopathies) |
| pubmed:29191965 | p(HGNC:TPH1) regulates a(CHEBI:dopamine) |
| pubmed:29191965 | p(HGNC:TPH1) regulates a(CHEBI:serotonin) |
| pubmed:29191965 | p(HGNC:TPH1) regulates act(p(HGNC:DDC)) |
| pubmed:29191965 | composite(p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:TPH1)) causesNoChange path(MESH:Tauopathies) |
| pubmed:29686391 | tloc(a(CONSO:"sonicated tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation a(CONSO:"sonicated tau fibrils") |
| pubmed:29686391 | a(CONSO:"sonicated tau fibrils") positiveCorrelation tloc(a(CONSO:"sonicated tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | g(HGNC:TP53) increases bp(GO:"mitotic G1 phase") |
| pubmed:29686391 | g(HGNC:TP53) decreases bp(GO:"cell proliferation") |
| pubmed:29686391 | bp(GO:"mitotic G1 phase") positiveCorrelation bp(GO:endocytosis) |
| pubmed:29686391 | bp(GO:"mitotic G1 phase") regulates tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | p(HGNC:CDK6) decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:18305152 | p(HGNC:CDK6) association act(p(HGNC:RB1)) |
| pubmed:18305152 | p(HGNC:CDK6) regulates bp(GO:"cell cycle") |
| pubmed:18305152 | act(p(HGNC:CDK6)) regulates bp(GO:"cell differentiation") |
| pubmed:18305152 | p(HGNC:CDK6) association path(EFO:neoplasm) |
| pubmed:18305152 | p(HGNC:CDK6) directlyIncreases p(HGNC:RB1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29686391 | a(CHEBI:palbociclib) increases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | a(CHEBI:palbociclib) decreases act(p(HGNC:CDK4)) |
| pubmed:29686391 | a(CHEBI:palbociclib) decreases act(p(HGNC:CDK6)) |
| pubmed:29686391 | p(HGNC:EXT2) association bp(GO:"heparan sulfate proteoglycan biosynthetic process") |
| pubmed:29686391 | p(HGNC:EXT2) increases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | p(HGNC:EXT2) increases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | p(HGNC:EXT2) increases tloc(a(CONSO:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | bp(GO:"heparan sulfate proteoglycan biosynthetic process") association p(HGNC:EXT2) |
| pubmed:29686391 | bp(GO:"heparan sulfate proteoglycan biosynthetic process") association p(HGNC:HS6ST1) |
| pubmed:29686391 | p(HGNC:HS6ST1) association bp(GO:"heparan sulfate proteoglycan biosynthetic process") |
| pubmed:29686391 | p(HGNC:HS6ST1) increases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | p(HGNC:HS6ST1) increases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | p(HGNC:HS6ST1) increases tloc(a(CONSO:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | p(HGNC:HS6ST1) increases a(CONSO:"6-O-sulfated heparin") |
| pubmed:29686391 | p(HGNC:DNM2) increases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | p(HGNC:DNM2) increases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | p(HGNC:DNM2) increases tloc(a(CONSO:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | a(CONSO:"6-O-sulfated heparin") increases complex(a(CONSO:"6-O-sulfated heparin"), p(CONSO:"Tau isoform F (441 aa)")) |
| pubmed:29686391 | a(CONSO:"6-O-sulfated heparin") decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | a(CONSO:"6-O-sulfated heparin") positiveCorrelation tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | a(CONSO:"6-O-sulfated heparin") increases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29980653 | a(CONSO:"6-O-sulfated heparin") increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | a(CONSO:"2-O-sulfated heparin") decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | a(CONSO:"2-O-sulfated heparin") decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | a(CHEBI:"chondroitin sulfate") decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | a(CHEBI:"chondroitin sulfate") increases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | a(MESH:"Heparitin Sulfate") decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | p(HGNC:SULF1) decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | p(HGNC:SULF1) decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | p(HGNC:SULF1) decreases tloc(p(CONSO:"6-O-sulfated heparin"), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) |
| pubmed:29686391 | p(HGNC:SULF2) decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | p(HGNC:SULF2) decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:29686391 | p(HGNC:SULF2) decreases tloc(p(CONSO:"6-O-sulfated heparin"), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) |
| pubmed:30985105 | p(HGNC:OGT) increases p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:30985105 | p(HGNC:OGT) increases p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:30985105 | act(p(HGNC:OGT)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30985105 | act(p(HGNC:OGT)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30985105 | act(p(HGNC:OGT)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:30985105 | act(p(HGNC:OGT)) increases p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:30985105 | act(p(HGNC:OGT)) decreases a(CONSO:"Tau aggregates") |
| pubmed:30985105 | p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) association bp(GO:"cellular glucose homeostasis") |
| pubmed:30985105 | p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) positiveCorrelation a(CHEBI:glucose) |
| pubmed:30985105 | p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) negativeCorrelation act(p(HGNC:OGA)) |
| pubmed:30985105 | p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) association bp(GO:"protein phosphorylation") |
| pubmed:30985105 | p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) association bp(GO:"protein phosphorylation") |
| pubmed:30985105 | p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) association bp(GO:"glucose metabolic process") |
| pubmed:30985105 | p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) negativeCorrelation deg(a(GO:"neurofibrillary tangle")) |
| pubmed:19732809 | p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) negativeCorrelation path(MESH:"Cardiovascular Diseases") |
| pubmed:19732809 | p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19732809 | p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) negativeCorrelation path(MESH:"Diabetes Mellitus, Type 2") |
| pubmed:19732809 | p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) association bp(MESH:"Hot Temperature") |
| pubmed:19732809 | p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) decreases act(complex(GO:"proteasome complex")) |
| pubmed:30985105 | p(HGNC:OGA) increases p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:30985105 | act(p(HGNC:OGA)) negativeCorrelation p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:30985105 | p(HGNC:OGA) association bp(GO:"brain development") |
| pubmed:30985105 | act(p(HGNC:OGA)) decreases p(HGNC:MTOR, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30985105 | act(p(HGNC:OGA)) decreases p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30985105 | act(p(HGNC:OGA)) decreases bp(GO:autophagy) |
| pubmed:30985105 | act(p(HGNC:OGA)) decreases p(HGNC:HTT, var("?")) |
| pubmed:30985105 | bp(GO:"cellular glucose homeostasis") association p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:30985105 | a(PUBCHEM:9576811) decreases act(p(HGNC:OGA)) |
| pubmed:30985105 | a(PUBCHEM:9576811) decreases act(p(HGNC:OGA)) |
| pubmed:30985105 | a(PUBCHEM:9576811) decreases act(a(MESH:Hexosaminidases)) |
| pubmed:30985105 | a(PUBCHEM:9576811) increases p(HGNC:APP, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:30985105 | a(PUBCHEM:9576811) increases p(HGNC:APP, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:30985105 | a(PUBCHEM:9576811) increases tloc(p(CONSO:sAPP-alpha), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30985105 | a(PUBCHEM:9576811) decreases tloc(a(CHEBI:"amyloid-beta polypeptide 40"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:30985105 | a(PUBCHEM:9576811) increases tloc(p(HGNC:APP), fromLoc(GO:"trans-Golgi network"), toLoc(GO:"plasma membrane")) |
| pubmed:30985105 | a(PUBCHEM:9576811) decreases tloc(p(HGNC:APP), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pubmed:30985105 | a(PUBCHEM:9576811) increases bp(CONSO:"APP processing") |
| pubmed:30985105 | a(PUBCHEM:135566354) increases tloc(a(PUBCHEM:135566354), fromLoc(MESH:Blood), toLoc(MESH:Brain)) |
| pubmed:30985105 | a(PUBCHEM:135566354) decreases act(p(HGNC:OGA)) |
| pubmed:30985105 | a(PUBCHEM:135566354) decreases act(p(HGNC:OGA)) |
| pubmed:30985105 | a(PUBCHEM:135566354) increases p(HGNC:MTOR, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30985105 | a(PUBCHEM:135566354) increases p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30985105 | a(PUBCHEM:135566354) increases p(HGNC:SNCA) |
| pubmed:30985105 | a(PUBCHEM:135566354) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:30985105 | a(PUBCHEM:135566354) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:30985105 | a(PUBCHEM:135566354) decreases a(CONSO:"Tau aggregates") |
| pubmed:30985105 | a(PUBCHEM:135566354) decreases a(CONSO:"Tau aggregates") |
| pubmed:30985105 | a(PUBCHEM:135566354) decreases a(CONSO:"Tau aggregates") |
| pubmed:30985105 | a(PUBCHEM:135566354) decreases a(CONSO:"Tau aggregates", loc(MESH:Brain)) |
| pubmed:30985105 | a(PUBCHEM:135566354) decreases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:30985105 | a(PUBCHEM:135566354) decreases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:30985105 | a(PUBCHEM:135566354) decreases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:30985105 | a(PUBCHEM:135566354) increases p(MGI:Mapt, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:30985105 | a(PUBCHEM:135566354) increases p(MGI:Mapt, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:30985105 | a(PUBCHEM:135566354) decreases bp(GO:"neuron death") |
| pubmed:30985105 | a(PUBCHEM:135566354) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Ser, 205)) |
| pubmed:30985105 | a(PUBCHEM:135566354) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 626)) |
| pubmed:30985105 | a(PUBCHEM:135566354) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) |
| pubmed:30985105 | a(PUBCHEM:135566354) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:30985105 | a(PUBCHEM:135566354) causesNoChange p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 400)) |
| pubmed:30985105 | a(PUBCHEM:135566354) decreases p(HGNC:MAPT, loc(MESH:"Cerebrospinal Fluid")) |
| pubmed:30985105 | a(PUBCHEM:135566354) increases bp(GO:cognition) |
| pubmed:30985105 | a(PUBCHEM:135566354) decreases a(CHEBI:amyloid-beta) |
| pubmed:30985105 | a(PUBCHEM:135566354) decreases path(MESH:"Plaque, Amyloid") |
| pubmed:30985105 | a(PUBCHEM:135566354) causesNoChange p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30985105 | deg(a(CONSO:"Dopaminergic cell groups")) positiveCorrelation path(MESH:"Parkinson Disease") |
| pubmed:30985105 | deg(a(CONSO:"Dopaminergic cell groups")) negativeCorrelation bp(GO:"motor behavior") |
| pubmed:30985105 | complex(p(HGNC:SNCA), p(HGNC:SNCA)) association path(MESH:"Parkinson Disease") |
| pubmed:30985105 | complex(a(CHEBI:phospholipid), p(HGNC:SNCA)) increases bp(GO:"SNARE complex assembly") |
| pubmed:30985105 | complex(p(HGNC:SNCA), p(HGNC:VAMP2)) increases bp(GO:"SNARE complex assembly") |
| pubmed:30985105 | p(HGNC:SNCA, frag("?_*")) increases a(CONSO:"alpha-synuclein aggregates") |
| pubmed:30985105 | p(CONSO:"alpha-synuclein fibrils", frag("?")) increases a(CONSO:"alpha-synuclein aggregates") |
| pubmed:30985105 | p(HGNC:SNCA, pmod(CONSO:O-GlcNAcylation)) decreases a(CONSO:"alpha-synuclein aggregates") |
| pubmed:30985105 | p(HGNC:SNCA, pmod(CONSO:O-GlcNAcylation)) increases a(CONSO:"alpha-synuclein oligomers") |
| pubmed:30985105 | p(HGNC:SNCA, pmod(CONSO:O-GlcNAcylation, Thr, 72)) decreases complex(p(HGNC:SNCA), p(HGNC:SNCA)) |
| pubmed:30985105 | p(HGNC:SNCA, pmod(CONSO:O-GlcNAcylation, Thr, 72)) decreases a(CONSO:"alpha-synuclein aggregates") |
| pubmed:30985105 | p(HGNC:SNCA, pmod(CONSO:O-GlcNAcylation, Thr, 72)) increases a(CONSO:"alpha-synuclein fibrils") |
| pubmed:30985105 | p(HGNC:SNCA, pmod(CONSO:O-GlcNAcylation, Ser, 87)) increases a(CONSO:"alpha-synuclein fibrils") |
| pubmed:30985105 | p(HGNC:SNCA, pmod(CONSO:O-GlcNAcylation, Thr, 75)) increases a(CONSO:"alpha-synuclein aggregates") |
| pubmed:30985105 | p(HGNC:SNCA, pmod(CONSO:O-GlcNAcylation, Thr, 81)) increases a(CONSO:"alpha-synuclein aggregates") |
| pubmed:30985105 | p(HGNC:SNCA, pmod(CONSO:O-GlcNAcylation, Ser, 87), pmod(CONSO:O-GlcNAcylation, Thr, 72), pmod(CONSO:O-GlcNAcylation, Thr, 81)) causesNoChange a(CONSO:"alpha-synuclein aggregates") |
| pubmed:30985105 | p(HGNC:SNCA, frag("68_77")) increases a(CONSO:"alpha-synuclein aggregates") |
| pubmed:30985105 | p(HGNC:SNCA, frag("68_77"), pmod(CONSO:O-GlcNAcylation)) increases a(CONSO:"alpha-synuclein aggregates") |
| pubmed:30985105 | p(HGNC:MTOR, pmod(go:0006468 ! "protein phosphorylation")) decreases bp(GO:autophagy) |
| pubmed:30985105 | act(p(MGI:Oga)) decreases bp(GO:autophagy) |
| pubmed:30985105 | act(p(RGD:Oga)) decreases bp(GO:autophagy) |
| pubmed:30985105 | p(RGD:Mapt, pmod(CONSO:O-GlcNAcylation)) negativeCorrelation p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30985105 | p(MGI:Mapt, pmod(CONSO:O-GlcNAcylation)) negativeCorrelation p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) |
| pubmed:30985105 | p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:16630055 | p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30985105 | p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) decreases a(CONSO:"Tau oligomers") |
| pubmed:30985105 | p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) decreases a(CONSO:"Tau oligomers") |
| pubmed:22833681 | p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:22833681 | p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:22833681 | p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:22833681 | p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) |
| pubmed:22833681 | p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:22833681 | p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) decreases a(CONSO:"Tau aggregates") |
| pubmed:19732809 | p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) negativeCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:30985105 | p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:O-GlcNAcylation)) decreases a(CONSO:"Tau oligomers") |
| pubmed:30985105 | p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation, Ser, 400)) decreases a(CONSO:"Tau aggregates") |
| pubmed:30985105 | p(CONSO:"VQIVYK motif", pmod(CONSO:O-GlcNAcylation)) decreases complex(p(CONSO:"VQIVYK motif"), p(CONSO:"VQIVYK motif")) |
| pubmed:30985105 | p(CONSO:"VQIVYK motif", pmod(CONSO:O-GlcNAcylation)) decreases a(CONSO:"Tau fibrils") |
| pubmed:26631930 | p(CONSO:"VQIVYK motif") increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(CONSO:"VQIVYK motif") increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(CONSO:"VQIVYK motif") increases a(CONSO:"Tau fibrils") |
| pubmed:17493042 | p(CONSO:"VQIVYK motif") partOf p(CONSO:"tubulin-binding repeat 3") |
| pubmed:17493042 | p(CONSO:"VQIVYK motif") increases p(CONSO:"paired helical filaments") |
| pubmed:17493042 | p(CONSO:"VQIVYK motif") increases bp(GO:"neurofibrillary tangle assembly") |
| pubmed:19363271 | p(CONSO:"VQIVYK motif") association p(FPLX:HSP90) |
| pubmed:19363271 | p(CONSO:"VQIVYK motif") isA p(CONSO:"tubulin-binding repeat 4") |
| pubmed:19363271 | p(CONSO:"VQIVYK motif") increases complex(p(FPLX:HSP90), p(HGNC:MAPT)) |
| pubmed:28002468 | p(CONSO:"VQIVYK motif") equivalentTo p(HGNC:MAP2, frag("332_339")) |
| pubmed:11606569 | p(CONSO:"VQIVYK motif") positiveCorrelation p(HGNC:MAPT, var("p.Lys280del")) |
| pubmed:11606569 | p(CONSO:"VQIVYK motif") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pubmed:11606569 | p(CONSO:"VQIVYK motif") increases p(CONSO:"Tau aggregates") |
| pubmed:26903089 | p(CONSO:"VQIVYK motif") association act(p(HGNC:FKBP4)) |
| pubmed:30985105 | p(HGNC:APP, pmod(CONSO:O-GlcNAcylation)) negativeCorrelation a(CHEBI:amyloid-beta) |
| pubmed:30985105 | p(HGNC:APP, pmod(CONSO:O-GlcNAcylation)) increases p(HGNC:APP, pmod(CONSO:O-GlcNAcylation), loc(GO:"plasma membrane")) |
| pubmed:30985105 | p(HGNC:APP, pmod(CONSO:O-GlcNAcylation), loc(GO:"plasma membrane")) increases bp(CONSO:"APP processing") |
| pubmed:30985105 | a(MESH:"1,2-dideoxy-2'-propylglucopyranoso(2,1-d)-delta 2'-thiazoline") decreases act(p(HGNC:OGA)) |
| pubmed:30985105 | a(MESH:"1,2-dideoxy-2'-propylglucopyranoso(2,1-d)-delta 2'-thiazoline") decreases a(CHEBI:amyloid-beta) |
| pubmed:30985105 | a(MESH:"1,2-dideoxy-2'-propylglucopyranoso(2,1-d)-delta 2'-thiazoline") decreases path(MESH:Gliosis) |
| pubmed:30985105 | a(MESH:"1,2-dideoxy-2'-propylglucopyranoso(2,1-d)-delta 2'-thiazoline") increases p(MGI:Sod1, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:30985105 | a(CHEBI:"prostaglandin J2") regulates path(MESH:Inflammation) |
| pubmed:30985105 | a(CHEBI:"prostaglandin J2") increases p(HGNC:APP, frag("?")) |
| pubmed:30985105 | a(CHEBI:"prostaglandin J2") increases p(HGNC:APP, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:30985105 | bp(GO:"vesicle transport along microtubule") association p(HGNC:HTT) |
| pubmed:30985105 | p(HGNC:HTT, pmod(CONSO:O-GlcNAcylation)) increases a(CONSO:"huntingtin aggregates") |
| pubmed:30985105 | p(HGNC:HTT, pmod(CONSO:O-GlcNAcylation)) decreases deg(a(CONSO:"huntingtin aggregates")) |
| pubmed:30985105 | p(HGNC:HTT, pmod(CONSO:O-GlcNAcylation)) decreases act(a(GO:autophagosome)) |
| pubmed:30985105 | p(HGNC:HTT, pmod(CONSO:O-GlcNAcylation)) decreases bp(GO:autophagy) |
| pubmed:30985105 | p(MGI:Sod1, var("?")) decreases p(MGI:Sod1, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:25374103 | p(MGI:Stub1) decreases act(p(MGI:Casp3)) |
| pubmed:25374103 | p(MGI:Stub1) decreases p(CONSO:"Tau C3") |
| pubmed:29311797 | p(MGI:Stub1) increases deg(p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:29311797 | p(MGI:Stub1) increases deg(p(MGI:Mapt, pmod(CONSO:misfolded))) |
| pubmed:25374103 | composite(p(CONSO:"Tau C3"), p(HGNC:STUB1)) increases complex(p(CONSO:"Tau C3"), p(HGNC:STUB1)) |
| pubmed:25374103 | composite(p(CONSO:"Tau C3"), p(HGNC:STUB1)) increases complex(p(CONSO:"Tau C3"), p(HGNC:STUB1)) |
| pubmed:25374103 | composite(p(CONSO:"Tau C3"), p(HGNC:STUB1)) decreases p(CONSO:"Tau C3") |
| pubmed:25374103 | composite(p(CONSO:"Tau C3"), p(HGNC:STUB1)) causesNoChange a(MESH:"HSP70 Heat-Shock Proteins") |
| pubmed:25374103 | composite(p(CONSO:"Tau C3"), p(HGNC:STUB1)) decreases p(HGNC:CASP3, frag("?")) |
| pubmed:25374103 | composite(p(CONSO:"Tau C3"), p(HGNC:STUB1)) increases bp(GO:"mitochondrion transport along microtubule") |
| pubmed:25374103 | composite(p(CONSO:"Tau C3"), p(HGNC:STUB1)) increases bp(GO:"mitochondrion transport along microtubule") |
| pubmed:25374103 | composite(p(CONSO:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) decreases p(CONSO:"Tau isoform F (441 aa)") |
| pubmed:25374103 | composite(p(CONSO:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) decreases p(HGNC:CASP3, frag("?")) |
| pubmed:25374103 | composite(p(CONSO:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) increases complex(p(CONSO:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) |
| pubmed:25374103 | composite(p(CONSO:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) decreases p(CONSO:"Tau C3") |
| pubmed:25374103 | composite(p(CONSO:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) increases bp(GO:"mitochondrion transport along microtubule") |
| pubmed:25374103 | composite(p(CONSO:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) increases bp(GO:"mitochondrion transport along microtubule") |
| pubmed:25374103 | composite(p(CONSO:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) decreases p(CONSO:"4R tau", var("p.Lys280del")) |
| pubmed:25374103 | composite(p(CONSO:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) decreases p(CONSO:"4R tau", var("p.Lys280del")) |
| pubmed:25374103 | composite(p(CONSO:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:25374103 | composite(p(CONSO:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) causesNoChange a(MESH:"HSP70 Heat-Shock Proteins") |
| pubmed:25374103 | composite(p(CONSO:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) increases bp(GO:"mitochondrion transport along microtubule") |
| pubmed:25374103 | composite(p(CONSO:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) increases bp(GO:"mitochondrion transport along microtubule") |
| pubmed:25374103 | composite(p(FPLX:HSP90), p(HGNC:STUB1)) increases complex(p(FPLX:HSP90), p(HGNC:STUB1)) |
| pubmed:25374103 | composite(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1)) increases complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1)) |
| pubmed:25374103 | complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1)) increases complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1), p(MESH:Proteins, pmod(CONSO:misfolded))) |
| pubmed:25374103 | composite(p(CONSO:"4R tau"), p(HGNC:STUB1)) increases a(MESH:"HSP70 Heat-Shock Proteins") |
| pubmed:25374103 | p(PFAM:"CHIP_TPR_N") increases complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(FPLX:HSP90), p(HGNC:STUB1)) |
| pubmed:25374103 | complex(p(HGNC:STUB1), p(INTERPRO:"U box domain")) increases p(CONSO:"Tau isoform F (441 aa)") |
| pubmed:25374103 | complex(p(HGNC:STUB1), p(INTERPRO:"U box domain")) increases p(CONSO:"4R tau", var("p.Lys280del")) |
| pubmed:28877763 | act(p(MGI:Syk)) positiveCorrelation bp(GO:"microglial cell activation") |
| pubmed:28877763 | act(p(MGI:Syk)) positiveCorrelation a(CONSO:"amyloid-beta aggregates") |
| pubmed:28877763 | act(p(MGI:Syk)) positiveCorrelation a(MESH:Neurites) |
| pubmed:28877763 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) |
| pubmed:25331948 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) |
| pubmed:28877763 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:25331948 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:28877763 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:25331948 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:28877763 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt) |
| pubmed:25331948 | p(MGI:Syk) increases a(CHEBI:amyloid-beta) |
| pubmed:25331948 | p(MGI:Syk) decreases deg(a(CHEBI:amyloid-beta)) |
| pubmed:25331948 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:28877763 | p(MGI:Syk, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation bp(GO:"microglial cell activation") |
| pubmed:28877763 | p(MGI:Syk, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation a(CONSO:"amyloid-beta aggregates") |
| pubmed:28877763 | p(MGI:Syk, pmod(go:0006468 ! "protein phosphorylation")) partOf a(CONSO:"dystrophic neurite") |
| pubmed:28877763 | p(MGI:Syk, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(MGI:Syk)) |
| pubmed:28877763 | p(MGI:Syk, pmod(go:0006468 ! "protein phosphorylation", Tyr, 525)) association a(CONSO:"Tau aggregates") |
| pubmed:28877763 | p(MGI:Syk, pmod(go:0006468 ! "protein phosphorylation", Tyr, 526)) association a(CONSO:"Tau aggregates") |
| pubmed:28877763 | p(HGNC:SYK, pmod(go:0006468 ! "protein phosphorylation")) association a(CONSO:"Tau aggregates") |
| pubmed:28877763 | p(HGNC:SYK, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation a(CONSO:"Tau aggregates") |
| pubmed:28877763 | p(HGNC:SYK, pmod(go:0006468 ! "protein phosphorylation")) association p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:28877763 | p(HGNC:SYK, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) |
| pubmed:28877763 | p(HGNC:SYK, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) |
| pubmed:28877763 | p(HGNC:SYK, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pubmed:28420982 | a(CONSO:"granular tau oligomers") increases a(CONSO:"Tau fibrils") |
| pubmed:28420982 | a(MESH:Exosomes) association tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:29238289 | act(a(MESH:Exosomes)) association p(HGNC:MAPT) |
| pubmed:28420982 | a(MESH:Exosomes) association path(MESH:"Plaque, Amyloid") |
| pubmed:28420982 | a(MESH:Exosomes) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) |
| pubmed:28420982 | a(GO:microvesicle) association tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28420982 | a(GO:microvesicle) regulates tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28420982 | complex(a(GO:vesicle), a(MESH:"Cell Membrane")) increases tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:28420982 | complex(p(HGNC:CHRM1), p(HGNC:MAPT)) increases path(MESH:Tauopathies) |
| pubmed:28420982 | complex(p(HGNC:CHRM3), p(HGNC:MAPT)) increases path(MESH:Tauopathies) |
| pubmed:28420982 | complex(a(CONSO:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular space"), toLoc(GO:"intracellular part")) |
| pubmed:28420982 | complex(a(CONSO:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases a(CONSO:"Tau aggregates") |
| pubmed:28420982 | complex(a(CONSO:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases complex(a(CONSO:"Tau aggregates"), a(GO:"cell surface")) |
| pubmed:28420982 | complex(a(CONSO:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases bp(GO:macropinocytosis) |
| pubmed:28420982 | a(MESH:"Heparan Sulfate Proteoglycans") association bp(GO:"neurofibrillary tangle assembly") |
| pubmed:28420982 | a(MESH:"Heparan Sulfate Proteoglycans") association a(CONSO:"dense core plaques") |
| pubmed:28420982 | a(MESH:"Heparan Sulfate Proteoglycans") association path(MESH:"Cerebral Amyloid Angiopathy, Familial") |
| pubmed:28420982 | a(MESH:"Heparan Sulfate Proteoglycans") increases a(CONSO:"Tau fibrils") |
| pubmed:28420982 | a(MESH:"Heparan Sulfate Proteoglycans") increases a(CONSO:"amyloid-beta fibrils") |
| pubmed:28420982 | a(MESH:"Heparan Sulfate Proteoglycans") increases complex(a(CONSO:"Tau aggregates"), a(GO:"cell surface")) |
| pubmed:28420982 | a(MESH:"Heparan Sulfate Proteoglycans") increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular space"), toLoc(GO:"intracellular part")) |
| pubmed:28420982 | a(CONSO:"dense core plaques") association a(MESH:"Heparan Sulfate Proteoglycans") |
| pubmed:28420982 | a(CONSO:"Tau annular protofibrils") association path(MESH:Tauopathies) |
| pubmed:28420982 | complex(p(HGNC:DNM1L), p(HGNC:MAPT)) increases bp(HP:Neurodegeneration) |
| pubmed:28420982 | p(HGNC:MAPT, frag("421_?")) decreases bp(GO:"mitochondrion organization") |
| pubmed:28420982 | complex(p(HGNC:APAF1), p(HGNC:CYCS)) increases act(p(HGNC:CASP9)) |
| pubmed:23702978 | complex(p(HGNC:APAF1), p(HGNC:CYCS)) increases bp(GO:"apoptosome assembly") |
| pubmed:29311797 | path(MESH:"Chronic Traumatic Encephalopathy") isA path(MESH:Tauopathies) |
| pubmed:29276758 | path(MESH:"Chronic Traumatic Encephalopathy") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:29311797 | p(HGNC:HSP90AA1) association bp(GO:growth) |
| pubmed:29311797 | p(HGNC:HSP90AA1) association bp(GO:"regulation of cell cycle") |
| pubmed:29311797 | p(HGNC:HSP90AA1) association bp(MESH:Cytoprotection) |
| pubmed:29311797 | p(HGNC:HSP90AA1) association path(MESH:"Neoplasm Metastasis") |
| pubmed:29311797 | bp(GO:growth) association p(HGNC:HSP90AA1) |
| pubmed:29311797 | bp(MESH:Cytoprotection) association p(HGNC:HSP90AA1) |
| pubmed:29311797 | path(MESH:"Neoplasm Metastasis") association p(HGNC:HSP90AA1) |
| pubmed:29311797 | bp(GO:"cell maturation") association p(HGNC:HSP90AB1) |
| pubmed:29311797 | bp(GO:"adaptation of signaling pathway") association p(HGNC:HSP90AB1) |
| pubmed:29311797 | p(HGNC:PPID) isA a(MESH:Immunophilins) |
| pubmed:29311797 | p(HGNC:PPID) decreases a(CONSO:"Tau fibrils") |
| pubmed:29311797 | p(HGNC:PPID) decreases a(CONSO:"Tau aggregates") |
| pubmed:29311797 | p(HGNC:PPID) increases bp(GO:memory) |
| pubmed:29311797 | p(HGNC:PPID) decreases bp(GO:"neuron apoptotic process") |
| pubmed:29311797 | p(HGNC:FKBPL) isA a(MESH:Immunophilins) |
| pubmed:29311797 | complex(p(FPLX:HSP90), p(HGNC:AIP)) regulates bp(GO:"glucocorticoid receptor signaling pathway") |
| pubmed:29311797 | complex(p(HGNC:FKBP4), p(HGNC:MAPT)) increases a(CONSO:"Tau aggregates") |
| pubmed:29311797 | bp(GO:"glucocorticoid receptor signaling pathway") association a(CONSO:"Tau aggregates") |
| pubmed:29311797 | p(HGNC:TOMM34) decreases path(MESH:Tauopathies) |
| pubmed:29311797 | complex(p(FPLX:HSP90), p(HGNC:CDC37)) increases p(HGNC:GSK3B) |
| pubmed:29311797 | complex(p(FPLX:HSP90), p(HGNC:CDC37)) increases p(HGNC:MAPK13) |
| pubmed:21367866 | complex(p(FPLX:HSP90), p(HGNC:CDC37)) positiveCorrelation act(p(HGNC:AKT1), ma(go:0016301 ! "kinase activity")) |
| pubmed:21367866 | complex(p(FPLX:HSP90), p(HGNC:CDC37)) negativeCorrelation deg(p(HGNC:MAPT)) |
| pubmed:29311797 | act(p(HGNC:MAPK13), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:11943212 | p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) |
| pubmed:11943212 | p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 396)) |
| pubmed:11943212 | p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:11943212 | p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:29311797 | p(MGI:Ahsa1) increases a(CONSO:"Tau oligomers") |
| pubmed:29311797 | p(MGI:Ahsa1) increases bp(GO:"neuron apoptotic process") |
| pubmed:29311797 | p(HGNC:S100A1) increases p(HGNC:MAPT) |
| pubmed:29311797 | p(HGNC:S100A1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29311797 | complex(p(FPLX:HSP90), p(HGNC:FNIP1)) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pubmed:29311797 | complex(p(FPLX:HSP90), p(HGNC:FNIP1), p(HGNC:FNIP2)) increases p(HGNC:FLCN) |
| pubmed:29311797 | p(FPLX:HSP90, pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(FPLX:HSP90)) |
| pubmed:29311797 | p(FPLX:HSP90, pmod(go:0006473 ! "protein acetylation")) decreases complex(a(CHEBI:ATP), p(FPLX:HSP90)) |
| pubmed:29311797 | p(FPLX:HSP90, pmod(go:0017014 ! "protein nitrosylation")) decreases act(p(FPLX:HSP90)) |
| pubmed:29311797 | p(FPLX:HSP90, pmod(go:0016567 ! "protein ubiquitination")) decreases act(p(FPLX:HSP90)) |
| pubmed:29311797 | p(FPLX:HSP90, pmod(GO:"protein oxidation")) decreases act(p(FPLX:HSP90)) |
| pubmed:29311797 | a(CONSO:EC102) increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) |
| pubmed:29311797 | a(PUBCHEM:14719853) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pubmed:29311797 | a(PUBCHEM:14719853) decreases p(MGI:Mapt) |
| pubmed:29311797 | a(CHEBI:"withaferin A") decreases act(p(FPLX:HSP90)) |
| pubmed:29311797 | a(CHEBI:"withaferin A") decreases act(p(HGNC:CDC37)) |
| pubmed:29311797 | a(CHEBI:"withaferin A") decreases p(HGNC:MAPT) |
| pubmed:27181519 | a(CHEBI:"withaferin A") association bp(GO:autophagy) |
| pubmed:29311797 | a(PUBCHEM:162859) decreases complex(p(FPLX:HSP90), p(HGNC:CDC37)) |
| pubmed:29311797 | a(PUBCHEM:162859) causesNoChange act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pubmed:29311797 | a(PUBCHEM:4456430) decreases path(MESH:"Alzheimer Disease") |
| pubmed:29311797 | a(CONSO:KU-177) decreases act(p(HGNC:AHSA1)) |
| pubmed:29311797 | a(CONSO:KU-177) decreases p(HGNC:MAPT, var("p.Pro301Leu")) |
| pubmed:26751493 | r(MGI:Mapt) partOf a(CL:0000127) |
| pubmed:26751493 | r(MGI:Mapt) partOf a(CL:0000128) |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 68)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 69)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 71)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 113)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 123)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 153)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 175)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 184)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 185)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 191)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 197)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23088643 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 197)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:16566606 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 197)) positiveCorrelation a(GO:microtubule) |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 210)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 237)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 238)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 258)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 289)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 394)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 394)) association a(CONSO:"paired helical filaments") |
| pubmed:16566606 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 394)) negativeCorrelation act(p(HGNC:MAPT)) |
| pubmed:16566606 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 394)) positiveCorrelation a(GO:microtubule) |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 403)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 409)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 435)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 427)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26751493 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 433)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26751493 | p(CONSO:"microtubule-binding region") association p(HGNC:HDAC6) |
| pubmed:26751493 | p(CONSO:"microtubule-binding region") association p(HGNC:HDAC6) |
| pubmed:26751493 | p(CONSO:"microtubule-binding region") partOf p(HGNC:MAPT) |
| pubmed:17493042 | p(CONSO:"microtubule-binding region") partOf p(HGNC:MAPT) |
| pubmed:17493042 | p(CONSO:"microtubule-binding region") increases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) |
| pubmed:10464280 | p(CONSO:"microtubule-binding region") isA p(HGNC:MAPT) |
| pubmed:10537045 | p(CONSO:"microtubule-binding region") partOf p(HGNC:MAPT) |
| pubmed:26751493 | p(CONSO:"microtubule-binding region") partOf p(HGNC:MAPT) |
| pubmed:17493042 | p(CONSO:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("199_370")) |
| pubmed:21757739 | p(CONSO:"microtubule-binding region") partOf p(CONSO:"assembly domain") |
| pubmed:21757739 | p(CONSO:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("244_369")) |
| pubmed:1918161 | p(CONSO:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("237_367")) |
| pubmed:10464280 | p(CONSO:"microtubule-binding region") positiveCorrelation act(complex(GO:microtubule)) |
| pubmed:18500754 | p(CONSO:"microtubule-binding region") association p(HGNC:HSPA8) |
| pubmed:18500754 | p(CONSO:"microtubule-binding region") association p(INTERPRO:"Heat shock protein 70kD, C-terminal domain superfamily") |
| pubmed:8391280 | p(CONSO:"microtubule-binding region") association p(FPLX:Ubiquitin) |
| pubmed:10537045 | p(CONSO:"microtubule-binding region") association act(p(HGNC:TGM2)) |
| pubmed:26751493 | p(CONSO:"tubulin-binding repeat 1") association g(CONSO:"APOE e3") |
| pubmed:26751493 | p(CONSO:"tubulin-binding repeat 1") association g(CONSO:"APOE e3") |
| pubmed:26751493 | p(CONSO:"tubulin-binding repeat 1") partOf p(CONSO:"microtubule-binding region") |
| pubmed:17493042 | p(CONSO:"tubulin-binding repeat 1") partOf p(CONSO:"microtubule-binding region") |
| pubmed:26751493 | p(CONSO:"tubulin-binding repeat 1") partOf p(CONSO:"microtubule-binding region") |
| pubmed:17493042 | p(CONSO:"tubulin-binding repeat 1") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat") |
| pubmed:17493042 | p(CONSO:"tubulin-binding repeat 1") equivalentTo p(CONSO:"Tau isoform F (441 aa)", frag("244_274")) |
| pubmed:23407988 | p(CONSO:"tubulin-binding repeat 1") partOf p(CONSO:"4R tau") |
| pubmed:23407988 | p(CONSO:"tubulin-binding repeat 1") partOf p(CONSO:"3R tau") |
| pubmed:26751493 | g(CONSO:"APOE e3") association p(CONSO:"tubulin-binding repeat 1") |
| pubmed:26751493 | g(CONSO:"APOE e3") association p(CONSO:"tubulin-binding repeat 1") |
| pubmed:26751493 | p(CONSO:"projection domain") association p(HGNC:LCK) |
| pubmed:26751493 | p(CONSO:"projection domain") association p(HGNC:FGR) |
| pubmed:26751493 | p(CONSO:"projection domain") association p(HGNC:SRC) |
| pubmed:26751493 | p(CONSO:"projection domain") association p(HGNC:GRB2) |
| pubmed:26751493 | p(CONSO:"projection domain") association p(FPLX:PLC) |
| pubmed:26751493 | p(CONSO:"projection domain") association a(CHEBI:phosphatidylinositol) |
| pubmed:26751493 | p(CONSO:"projection domain") association a(CHEBI:"phosphatidylinositol bisphosphate") |
| pubmed:26751493 | p(CONSO:"projection domain") association p(HGNC:PIN1) |
| pubmed:26751493 | p(CONSO:"projection domain") partOf p(HGNC:MAPT) |
| pubmed:17493042 | p(CONSO:"projection domain") partOf p(HGNC:MAPT) |
| pubmed:26751493 | p(CONSO:"projection domain") association p(HGNC:FYN) |
| pubmed:26751493 | p(CONSO:"projection domain") association p(HGNC:DLG4) |
| pubmed:26751493 | p(CONSO:"projection domain") association a(MESH:"Receptors, N-Methyl-D-Aspartate") |
| pubmed:17493042 | p(CONSO:"projection domain") equivalentTo p(INTERPRO:"MAP2/Tau projection") |
| pubmed:17493042 | p(CONSO:"projection domain") equivalentTo p(HGNC:MAPT, frag("1_198")) |
| pubmed:26751493 | p(CONSO:"projection domain") association p(MESH:"Receptors, N-Methyl-D-Aspartate") |
| pubmed:26751493 | p(HGNC:FGR) association p(CONSO:"projection domain") |
| pubmed:26751493 | p(HGNC:GRB2) association p(CONSO:"projection domain") |
| pubmed:26751493 | a(CHEBI:"phosphatidylinositol bisphosphate") association p(CONSO:"projection domain") |
| pubmed:26751493 | path(CONSO:"Argyrophilic Grain Disease") positiveCorrelation p(CONSO:"4R tau") |
| pubmed:26751493 | p(HGNC:MAPT, var("p.Val337Met")) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Val337Met")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Val337Met")) increases a(CONSO:"Tau aggregates") |
| pubmed:26751493 | p(HGNC:MAPT, var("p.Gly272Val")) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Gly272Val")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Gly272Val")) increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Gly272Val")) decreases p(CONSO:"4R tau") |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Gly272Val")) increases p(CONSO:"3R tau") |
| pubmed:26751493 | p(HGNC:MAPT, var("p.Arg406Trp")) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Arg406Trp")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Arg406Trp")) increases a(CONSO:"Tau aggregates") |
| pubmed:26751493 | p(HGNC:PSEN1, var("p.Gly183Val")) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pubmed:26751493 | p(HGNC:PSEN1, var("p.Gly183Val")) positiveCorrelation path(MESH:"Niemann-Pick Diseases") |
| pubmed:26751493 | p(HGNC:PSEN1, var("p.Gly183Val")) causesNoChange a(CHEBI:amyloid-beta) |
| pubmed:26751493 | g(DBSNP:rs2471738) association path(MESH:"Parkinson Disease") |
| pubmed:26751493 | g(DBSNP:rs242557) association path(MESH:"Parkinson Disease") |
| pubmed:26751493 | p(HGNC:MAPT, var("p.Glu391*")) association p(CONSO:"paired helical filaments") |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Glu391*")) partOf a(GO:"neurofibrillary tangle") |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Glu391*")) isA p(HGNC:MAPT) |
| pubmed:22002427 | p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:22002427 | p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 205)) |
| pubmed:26751493 | p(HGNC:SNAP25) negativeCorrelation a(GO:"neurofibrillary tangle") |
| pubmed:26751493 | p(PFAM:Syntaxin) negativeCorrelation a(GO:"neurofibrillary tangle") |
| pubmed:26751493 | complex(a(CHEBI:heparin), p(CONSO:"Tau aggregates")) positiveCorrelation bp(GO:macropinocytosis) |
| pubmed:26751493 | complex(a(CHEBI:heparin), p(CONSO:"Tau aggregates")) association bp(GO:macropinocytosis) |
| pubmed:26751493 | bp(GO:"cell-cell signaling via exosome") isA tloc(a(CONSO:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) |
| pubmed:26751493 | a(CL:0000129) increases tloc(a(CONSO:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) |
| pubmed:26751493 | a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") decreases act(p(HGNC:PPME1)) |
| pubmed:26751493 | a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") increases bp(GO:cognition) |
| pubmed:26751493 | a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") increases bp(GO:"motor behavior") |
| pubmed:26751493 | a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") decreases act(p(MGI:Ppme1)) |
| pubmed:26751493 | p(CONSO:"Tau antibody, RG7345") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:26751493 | a(CHEBI:"azure A") increases bp(GO:"protein catabolic process") |
| pubmed:26751493 | a(CHEBI:"azure A") association bp(GO:"response to oxidative stress") |
| pubmed:26751493 | a(CHEBI:"azure A") decreases act(p(HGNC:CASP1)) |
| pubmed:26751493 | a(CHEBI:"azure A") decreases act(p(HGNC:CASP3)) |
| pubmed:26751493 | a(CHEBI:"azure B") increases bp(GO:"protein catabolic process") |
| pubmed:26751493 | a(CHEBI:"azure B") association bp(GO:"response to oxidative stress") |
| pubmed:26751493 | a(CHEBI:"azure B") decreases act(p(HGNC:CASP1)) |
| pubmed:26751493 | a(CHEBI:"azure B") decreases act(p(HGNC:CASP3)) |
| pubmed:26751493 | a(CONSO:thiohydantoin) decreases p(CONSO:"Tau aggregates") |
| pubmed:26751493 | a(CONSO:oxazolidinedione) decreases p(CONSO:"Tau aggregates") |
| pubmed:26751493 | a(CONSO:thioxooxazolidine) decreases p(CONSO:"Tau aggregates") |
| pubmed:26751493 | a(CHEBI:thiostrepton) decreases p(CONSO:"Tau aggregates") |
| pubmed:26751493 | a(CONSO:sudoxicam) decreases p(CONSO:"Tau aggregates") |
| pubmed:26751493 | a(CHEBI:isoniazide) decreases p(CONSO:"Tau aggregates") |
| pubmed:26751493 | a(CHEBI:Iproniazid) decreases p(CONSO:"Tau aggregates") |
| pubmed:26751493 | a(CHEBI:iproclozide) decreases p(CONSO:"Tau aggregates") |
| pubmed:26751493 | a(CONSO:isocarboxazide) decreases p(CONSO:"Tau aggregates") |
| pubmed:26751493 | a(CHEBI:myricetin) decreases p(CONSO:"Tau aggregates") |
| pubmed:26751493 | a(CHEBI:emodin) decreases p(CONSO:"Tau aggregates") |
| pubmed:26751493 | a(CHEBI:daunorubicin) decreases p(CONSO:"Tau aggregates") |
| pubmed:26751493 | a(CHEBI:quinalizarin) decreases p(CONSO:"Tau aggregates") |
| pubmed:26458742 | p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) |
| pubmed:26458742 | p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) |
| pubmed:26458742 | p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation", Ser, 400)) positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) |
| pubmed:26458742 | p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) |
| pubmed:26458742 | p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation", Ser, 409)) positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) |
| pubmed:26458742 | p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) |
| pubmed:26195256 | p(HGNC:CLU, var("?")) association path(MESH:"Alzheimer Disease") |
| pubmed:26195256 | path(MESH:"Craniocerebral Trauma") increases path(MESH:"Alzheimer Disease") |
| pubmed:26195256 | bp(MESH:Exercise) decreases path(MESH:"Alzheimer Disease") |
| pubmed:26195256 | a(MESH:"Cerebral Ventricles") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26195256 | path(MESH:"Cerebral Amyloid Angiopathy") association a(CONSO:"amyloid-beta aggregates") |
| pubmed:26195256 | p(MESH:Endopeptidases) increases bp(GO:"protein catabolic process") |
| pubmed:26195256 | p(MESH:Endopeptidases) increases deg(a(CHEBI:amyloid-beta, loc(GO:intracellular))) |
| pubmed:26195256 | act(complex(a(MESH:Endosomes), a(MESH:Lysosomes))) increases bp(GO:"protein catabolic process") |
| pubmed:26195256 | act(p(MESH:Cathepsins)) increases deg(a(CHEBI:amyloid-beta, loc(GO:intracellular))) |
| pubmed:26195256 | p(HGNC:MMP3) increases deg(a(CHEBI:amyloid-beta, loc(GO:"extracellular region"))) |
| pubmed:29626319 | act(p(HGNC:MMP3)) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:26195256 | p(HGNC:FOLH1) increases deg(a(CHEBI:amyloid-beta, loc(GO:"extracellular region"))) |
| pubmed:26195256 | p(HGNC:ECE1) increases deg(a(CHEBI:amyloid-beta, loc(GO:"extracellular region"))) |
| pubmed:29626319 | p(HGNC:ECE1) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:26195256 | p(HGNC:ECE2) increases deg(a(CHEBI:amyloid-beta, loc(GO:"extracellular region"))) |
| pubmed:26195256 | p(HGNC:PLAT) increases deg(a(CHEBI:amyloid-beta, loc(GO:"extracellular region"))) |
| pubmed:26195256 | p(HGNC:ACE) increases deg(a(CHEBI:amyloid-beta, loc(GO:"extracellular region"))) |
| pubmed:29626319 | p(HGNC:ACE) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | p(HGNC:ACE) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | p(HGNC:ACE) increases rxn(reactants(a(CHEBI:"Angiotensin I")), products(a(CHEBI:"angiotensin II"))) |
| pubmed:29626319 | p(HGNC:ACE) regulates a(MESH:"Body Fluids") |
| pubmed:29626319 | p(HGNC:ACE) regulates bp(MESH:"Blood Pressure") |
| pubmed:29626319 | p(HGNC:ACE) regulates bp(GO:"sodium ion transmembrane transport") |
| pubmed:29626319 | act(p(HGNC:ACE)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26195256 | a(MESH:"Muscle, Smooth, Vascular") increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:26195256 | p(MESH:Neprilysin) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26195256 | p(HGNC:LRP2) decreases a(CHEBI:amyloid-beta) |
| pubmed:26195256 | p(MESH:"ATP-Binding Cassette Transporters") increases tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Brain)) |
| pubmed:26195256 | act(p(HGNC:PPIA)) decreases bp(GO:"establishment of blood-brain barrier") |
| pubmed:26195256 | path(MESH:Sleep) increases act(a(MESH:"Blood-Brain Barrier")) |
| pubmed:26195256 | path(MESH:Sleep) decreases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | path(MESH:Sleep) decreases a(CHEBI:amyloid-beta) |
| pubmed:26195256 | path(MESH:Sleep) increases p(HGNC:LRP1) |
| pubmed:26195256 | a(MESH:"Cerebrospinal Fluid") negativeCorrelation path(MESH:Aging) |
| pubmed:26195256 | a(MESH:"Cerebrospinal Fluid") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26195256 | act(p(HGNC:AQP1)) negativeCorrelation path(MESH:Aging) |
| pubmed:26195256 | act(p(HGNC:AQP1)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26195256 | act(p(HGNC:AQP1)) increases a(MESH:"Cerebrospinal Fluid") |
| pubmed:26195256 | act(p(HGNC:AQP1)) increases tloc(a(CHEBI:water), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:29626319 | p(HGNC:AQP1) increases act(a(MESH:"Choroid Plexus")) |
| pubmed:29626319 | p(HGNC:AQP1) decreases a(CHEBI:amyloid-beta) |
| pubmed:26195256 | path(MESH:"Calcification, Physiologic") decreases a(MESH:"Cerebrospinal Fluid") |
| pubmed:26195256 | act(p(MESH:Calpain)) increases deg(p(HGNC:MAPT)) |
| pubmed:27373205 | p(HGNC:MAPT, var("p.Ser422Glu")) increases a(CONSO:"Tau aggregates") |
| pubmed:27373205 | p(HGNC:MAPT, var("p.Ser422Glu")) increases a(CONSO:"Tau oligomers") |
| pubmed:27373205 | p(HGNC:MAPT, var("p.Ser422Glu")) decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:27373205 | p(HGNC:MAPT, var("p.Ser422Glu")) causesNoChange bp(GO:"retrograde axonal protein transport") |
| pubmed:27373205 | composite(a(CONSO:"Tau aggregates"), p(HGNC:MAPT, var("p.Ser422Glu"))) increases a(CONSO:"Tau oligomers") |
| pubmed:27373205 | composite(a(CONSO:"Tau aggregates"), p(HGNC:MAPT, var("p.Ser422Glu"))) increases a(CONSO:"Tau dimers") |
| pubmed:27373205 | composite(a(CONSO:"Tau aggregates"), p(HGNC:MAPT, var("p.Ser422Glu"))) decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:27373205 | composite(a(CONSO:"Tau aggregates"), p(HGNC:MAPT, var("p.Ser422Glu"))) decreases bp(GO:"retrograde axonal protein transport") |
| pubmed:27373205 | composite(a(CONSO:"Tau aggregates"), p(HGNC:MAPT)) increases a(CONSO:"Tau oligomers") |
| pubmed:27373205 | composite(a(CONSO:"Tau aggregates"), p(HGNC:MAPT)) increases a(CONSO:"Tau dimers") |
| pubmed:26631930 | m(HGNC:MIR132) negativeCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pubmed:26631930 | m(HGNC:MIR132) decreases p(CONSO:"4R tau") |
| pubmed:26631930 | complex(r(HGNC:MAPT), r(HGNC:MIR219A1)) decreases p(HGNC:MAPT) |
| pubmed:26631930 | complex(GO:"ribonucleoprotein granule") increases p(HGNC:MAPT) |
| pubmed:27181519 | complex(GO:"ribonucleoprotein granule") association bp(GO:"RNA processing") |
| pubmed:27181519 | complex(GO:"ribonucleoprotein granule") regulates a(MESH:"RNA, Messenger") |
| pubmed:26631930 | p(HGNC:HM13) increases complex(GO:"ribonucleoprotein granule") |
| pubmed:26631930 | a(PUBCHEM:39484) decreases act(complex(GO:"mitochondrial respiratory chain complex I")) |
| pubmed:26631930 | p(HGNC:SRSF2) increases p(CONSO:"4R tau") |
| pubmed:29226865 | act(p(HGNC:SRSF2)) increases p(CONSO:"4R tau") |
| pubmed:26631930 | p(HGNC:SRSF2) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pubmed:29226865 | act(p(HGNC:SRSF2)) positiveCorrelation p(HGNC:SRSF2, pmod(go:0006473 ! "protein acetylation", Lys, 52)) |
| pubmed:26631930 | complex(a(MESH:RNA), p(HGNC:MAPT)) increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | complex(a(MESH:RNA), p(HGNC:MAPT)) increases path(CONSO:Neurodegeneration) |
| pubmed:24561250 | a(MESH:RNA) increases act(complex(GO:"inflammasome complex")) |
| pubmed:26631930 | complex(a(GO:microtubule), p(CONSO:"4R tau")) increases bp(GO:"microtubule polymerization") |
| pubmed:26631930 | complex(a(GO:microtubule), p(CONSO:"3R tau")) increases bp(GO:"microtubule polymerization") |
| pubmed:26631930 | p(HGNC:PPM1A) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214), pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:29238289 | rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, frag("1_421")), p(HGNC:MAPT, frag("421_*")))) increases tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:26631930 | complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) decreases complex(GO:"kinesin complex") |
| pubmed:26631930 | complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) decreases complex(GO:"kinesin complex") |
| pubmed:26631930 | complex(GO:"kinesin complex") regulates bp(GO:"axonal transport") |
| pubmed:19491104 | act(complex(GO:"kinesin complex")) positiveCorrelation act(p(HGNC:MAPK8IP1)) |
| pubmed:19491104 | act(complex(GO:"kinesin complex")) positiveCorrelation act(p(HGNC:KLC1)) |
| pubmed:19491104 | act(complex(GO:"kinesin complex")) positiveCorrelation bp(GO:"vesicle-mediated transport") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 163)) decreases deg(p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 163))) |
| pubmed:26192747 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 163)) isA p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 369)) decreases deg(p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 369))) |
| pubmed:26192747 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 369)) isA p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:26192747 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 369)) partOf p(CONSO:"microtubule-binding region") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006487 ! "protein N-linked glycosylation")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006487 ! "protein N-linked glycosylation")) increases a(CONSO:"paired helical filaments") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006487 ! "protein N-linked glycosylation")) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006487 ! "protein N-linked glycosylation")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006493 ! "protein O-linked glycosylation")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006493 ! "protein O-linked glycosylation")) decreases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006493 ! "protein O-linked glycosylation")) decreases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006493 ! "protein O-linked glycosylation")) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:glycation)) association a(CONSO:"paired helical filaments") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:glycation)) increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:glycation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:19517062 | p(HGNC:MAPT, pmod(CONSO:glycation)) increases a(CHEBI:"advanced glycation end-product") |
| pubmed:19517062 | p(HGNC:MAPT, pmod(CONSO:glycation)) partOf p(CONSO:"Tau aggregates") |
| pubmed:19517062 | p(HGNC:MAPT, pmod(CONSO:glycation)) increases a(CONSO:"Tau oligomers") |
| pubmed:19517062 | p(HGNC:MAPT, pmod(CONSO:glycation)) increases complex(a(CHEBI:"advanced glycation end-product"), p(HGNC:MAPT, pmod(CONSO:glycation))) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(GO:"protein peptidyl-prolyl isomerization")) association a(CONSO:"paired helical filaments") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(GO:"protein peptidyl-prolyl isomerization")) increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) positiveCorrelation path(MESH:Tauopathies) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) regulates a(CONSO:"Tau aggregates") |
| pubmed:16566606 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) decreases bp(GO:"tubulin complex assembly") |
| pubmed:16566606 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) association p(HGNC:MAPT, pmod(CONSO:misfolded)) |
| pubmed:22057784 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pubmed:18562203 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) association act(a(MESH:Astrocytes)) |
| pubmed:18562203 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pubmed:17050703 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) isA p(HGNC:MAPT, pmod(CONSO:nitration)) |
| pubmed:16566606 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) decreases bp(GO:"microtubule polymerization") |
| pubmed:16566606 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) positiveCorrelation a(CONSO:"paired helical filaments") |
| pubmed:16566606 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) negativeCorrelation act(p(HGNC:MAPT)) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:17050703 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) positiveCorrelation path(MESH:Tauopathies) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) regulates a(CONSO:"Tau aggregates") |
| pubmed:16566606 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) decreases bp(GO:"tubulin complex assembly") |
| pubmed:16566606 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) association p(HGNC:MAPT, pmod(CONSO:misfolded)) |
| pubmed:22057784 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pubmed:17050703 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) association a(CONSO:"paired helical filaments") |
| pubmed:16566606 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) positiveCorrelation a(CONSO:"paired helical filaments") |
| pubmed:17050703 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) positiveCorrelation bp(GO:"neurofibrillary tangle assembly") |
| pubmed:17050703 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) partOf a(GO:"neurofibrillary tangle") |
| pubmed:17050703 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) partOf path(MESH:"Plaque, Amyloid") |
| pubmed:17050703 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) partOf a(MESH:"Neuropil Threads") |
| pubmed:17050703 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) association path(CONSO:"Corticobasal Degeneration") |
| pubmed:17050703 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) association path(MESH:"Supranuclear Palsy, Progressive") |
| pubmed:17050703 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) isA p(HGNC:MAPT, pmod(CONSO:nitration)) |
| pubmed:16566606 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) decreases bp(GO:"microtubule polymerization") |
| pubmed:16566606 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) negativeCorrelation act(p(HGNC:MAPT)) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) positiveCorrelation path(MESH:Tauopathies) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:26631930 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) regulates a(CONSO:"Tau aggregates") |
| pubmed:16566606 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) decreases bp(GO:"tubulin complex assembly") |
| pubmed:16566606 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) association p(HGNC:MAPT, pmod(CONSO:misfolded)) |
| pubmed:16566606 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) decreases bp(GO:"microtubule polymerization") |
| pubmed:16566606 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) positiveCorrelation a(CONSO:"paired helical filaments") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys)) decreases a(CONSO:"Tau aggregates") |
| pubmed:24869773 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys)) decreases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation")) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26631930 | p(HGNC:MAPT, frag("26_230")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26631930 | p(HGNC:MAPT, frag("124_441")) directlyIncreases complex(a(GO:microtubule), p(HGNC:MAPT, frag("124_441"))) |
| pubmed:26631930 | complex(p(HGNC:DCTN1), p(HGNC:MAPT)) increases complex(a(GO:microtubule), p(HGNC:DCTN1)) |
| pubmed:8391280 | complex(p(HGNC:DCTN1), p(HGNC:MAPT)) isA p(INTERPRO:"Dynein associated protein") |
| pubmed:8391280 | complex(p(HGNC:DCTN1), p(HGNC:MAPT)) negativeCorrelation g(DBSNP:rs63750424) |
| pubmed:26631930 | complex(a(GO:microtubule), p(HGNC:DCTN1)) increases complex(a(GO:microtubule), a(MESH:Dyneins)) |
| pubmed:26631930 | complex(p(HGNC:APP), p(HGNC:SLC40A1)) increases tloc(a(CHEBI:"iron(0)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:26631930 | complex(a(MESH:Actins), p(HGNC:MAPT)) increases a(GO:"actin filament bundle") |
| pubmed:26631930 | complex(a(MESH:Actins), p(HGNC:MAPT)) regulates a(GO:"actin cytoskeleton") |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Asn279Lys")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Asn279Lys")) increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Arg5His")) decreases complex(p(HGNC:DCTN1), p(HGNC:MAPT)) |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Arg5His")) decreases bp(GO:"axonal transport") |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Arg5His")) decreases act(p(HGNC:MAPT)) |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Arg5Leu")) decreases complex(p(HGNC:DCTN1), p(HGNC:MAPT)) |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Arg5Leu")) decreases bp(GO:"axonal transport") |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Leu266Val")) decreases p(CONSO:"4R tau") |
| pubmed:26631930 | p(HGNC:MAPT, var("p.Leu266Val")) increases p(CONSO:"3R tau") |
| pubmed:26631930 | p(CONSO:"VQIINK motif") increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(CONSO:"VQIINK motif") increases a(CONSO:"Tau aggregates") |
| pubmed:17493042 | p(CONSO:"VQIINK motif") partOf p(CONSO:"tubulin-binding repeat 2") |
| pubmed:17493042 | p(CONSO:"VQIINK motif") increases p(CONSO:"paired helical filaments") |
| pubmed:17493042 | p(CONSO:"VQIINK motif") increases bp(GO:"neurofibrillary tangle assembly") |
| pubmed:28002468 | p(CONSO:"VQIINK motif") equivalentTo p(HGNC:MAP4, frag("992_999")) |
| pubmed:28002468 | p(CONSO:"VQIINK motif") equivalentTo p(HGNC:MAP4, frag("1023_1030")) |
| pubmed:11606569 | p(CONSO:"VQIINK motif") positiveCorrelation p(HGNC:MAPT, var("p.Lys280del")) |
| pubmed:11606569 | p(CONSO:"VQIINK motif") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pubmed:11606569 | p(CONSO:"VQIINK motif") increases p(CONSO:"Tau aggregates") |
| pubmed:26631930 | a(CHEBI:"polyanionic polymer") increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | a(CHEBI:"polyanionic polymer") increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:YWHAZ) increases a(CONSO:"Tau aggregates") |
| pubmed:12551948 | p(HGNC:YWHAZ) isA complex(p(HGNC:GSK3B), p(HGNC:MAPT), p(HGNC:YWHAZ)) |
| pubmed:12551948 | p(HGNC:YWHAZ) association p(HGNC:MAPT) |
| pubmed:12551948 | p(HGNC:YWHAZ) association p(HGNC:GSK3B) |
| pubmed:12551948 | p(HGNC:YWHAZ) increases act(p(HGNC:GSK3B)) |
| pubmed:22941973 | act(p(HGNC:YWHAZ)) increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:22941973 | act(p(HGNC:YWHAZ)) decreases complex(a(MESH:Microtubules), p(RGD:Mapt)) |
| pubmed:22941973 | act(p(HGNC:YWHAZ)) decreases bp(GO:"microtubule polymerization") |
| pubmed:22941973 | act(p(HGNC:YWHAZ)) increases deg(p(RGD:Syp)) |
| pubmed:22941973 | act(p(HGNC:YWHAZ)) increases act(p(FPLX:Proteasome)) |
| pubmed:26631930 | p(HGNC:MAPT, frag("151_391")) increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, frag("1_368")) increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:MAPT, frag("1_368")) increases path(CONSO:Neurodegeneration) |
| pubmed:26631930 | p(HGNC:MAPT, frag("1_368")) decreases bp(GO:"microtubule polymerization") |
| pubmed:26631930 | p(HGNC:F2) increases p(HGNC:MAPT, frag("258_360")) |
| pubmed:26631930 | p(HGNC:MAPT, frag("258_360")) increases a(CONSO:"Tau aggregates") |
| pubmed:26631930 | p(HGNC:CTSL) increases p(HGNC:MAPT, frag("258_360")) |
| pubmed:26631930 | bp(GO:"iron ion transport") association p(HGNC:MAPT) |
| pubmed:26631930 | bp(GO:"DNA protection") association p(HGNC:MAPT) |
| pubmed:26631930 | tloc(p(HGNC:TTLL6), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) increases act(a(CHEBI:amyloid-beta)) |
| pubmed:26631930 | p(HGNC:SPAST) increases bp(GO:"microtubule severing") |
| pubmed:26631930 | p(HGNC:GRIN2B, pmod(go:0006468 ! "protein phosphorylation")) increases complex(p(HGNC:DLG4), p(HGNC:GRIN2B)) |
| pubmed:26631930 | complex(p(HGNC:DLG4), p(HGNC:GRIN2B)) increases act(a(GO:"glutamatergic synapse")) |
| pubmed:26631930 | complex(p(HGNC:DLG4), p(HGNC:GRIN2B)) increases act(a(CHEBI:amyloid-beta)) |
| pubmed:22817713 | complex(a(CONSO:"Tau oligomers"), p(HGNC:HSPA1A)) decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:22817713 | complex(a(CONSO:"Tau oligomers"), p(HGNC:HSPA1A)) increases bp(GO:"anterograde axonal protein transport") |
| pubmed:22817713 | bp(GO:"regulation of microtubule cytoskeleton organization") association p(HGNC:MAPT) |
| pubmed:22817713 | a(CHEBI:"arachidonic acid") increases a(CONSO:"Tau oligomers") |
| pubmed:22817713 | a(CHEBI:"arachidonic acid") increases a(CONSO:"Tau aggregates") |
| pubmed:22817713 | p(HGNC:PPP1CA) decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:29334120 | p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 397)) |
| pubmed:29334120 | p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 403)) |
| pubmed:29334120 | p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:29334120 | p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 409)) |
| pubmed:29334120 | p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 410)) |
| pubmed:26142647 | act(p(HGNC:PPP1CA)) directlyDecreases p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25001178 | p(HGNC:PPP1CA) directlyDecreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:25001178 | p(HGNC:PPP1CA) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22817713 | p(HGNC:MAPT, frag("2_18")) decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:26671985 | p(HGNC:MAPT, frag("2_18")) equivalentTo p(CONSO:"phosphatase-activating domain") |
| pubmed:26671985 | p(HGNC:MAPT, frag("2_18")) partOf p(HGNC:MAPT, frag("1_151")) |
| pubmed:22817713 | composite(p(HGNC:HSPA1A), p(HGNC:MAPT, frag("2_18"))) decreases bp(GO:"anterograde axonal protein transport") |
| pubmed:29626319 | p(FPLX:UBE2) increases deg(a(MESH:Proteins)) |
| pubmed:29626319 | p(HGNC:PSMD7) increases deg(a(MESH:Proteins)) |
| pubmed:29626319 | a(MESH:"Ubiquitin-Protein Ligases") increases deg(a(MESH:Proteins)) |
| pubmed:29626319 | a(MESH:"Tight Junctions") decreases tloc(a(MESH:Proteins), fromLoc(MESH:Brain), toLoc(MESH:Blood)) |
| pubmed:29626319 | a(HP:"glymphatic system") decreases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | a(HP:"glymphatic system") decreases p(HGNC:MAPT) |
| pubmed:29626319 | p(HGNC:UBB, var("?")) decreases act(p(HGNC:PSMD7)) |
| pubmed:29626319 | p(HGNC:UBB, var("?")) decreases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | p(FPLX:MMP) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | p(HGNC:SERPINF2) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | p(HGNC:SERPINF2) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | p(HGNC:SERPINF2) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29626319 | act(p(HGNC:SERPINF2)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29626319 | a(MESH:"Receptors, Scavenger") increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | p(HGNC:CMKLR1) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | p(FPLX:TLR) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:23702978 | act(p(FPLX:TLR)) increases p(HGNC:NLRP3) |
| pubmed:23702978 | act(p(FPLX:TLR)) increases p(HGNC:IL1B) |
| pubmed:29626319 | p(HGNC:FPR2) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | a(HP:"blood-cerebrospinal fluid barrier") decreases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | complex(a(CHEBI:amyloid-beta), p(HGNC:TTR)) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | a(MESH:"Lymph Nodes") decreases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | complex(a(MESH:Erythrocytes), p(HGNC:CR1)) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | composite(a(CHEBI:amyloid-beta), a(MESH:"Serum Albumin")) decreases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | a(MESH:Aminopeptidases) increases deg(p(HGNC:MAPT)) |
| pubmed:29626319 | a(MESH:Thrombin) increases deg(p(HGNC:MAPT)) |
| pubmed:29626319 | a(MESH:tenuigenin) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pubmed:29626319 | a(MESH:tenuigenin) increases p(HGNC:PSMD7) |
| pubmed:29626319 | bp(GO:"cAMP-mediated signaling") increases p(HGNC:PSMD7) |
| pubmed:29626319 | a(CHEBI:wogonin) increases bp(GO:autophagy) |
| pubmed:29626319 | a(CHEBI:wogonin) decreases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | a(CHEBI:wogonin) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:29626319 | p(HGNC:NPAS4) increases bp(GO:autophagy) |
| pubmed:29626319 | p(HGNC:NPAS4) increases deg(p(HGNC:MAPT)) |
| pubmed:29626319 | p(HGNC:NPAS4) increases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:29626319 | a(CHEBI:statin) increases tloc(p(HGNC:IDE), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:29626319 | a(CHEBI:statin) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | a(CHEBI:"omega-3 fatty acid") increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | a(CHEBI:"all-cis-5,8,11,14,17-icosapentaenoic acid") increases act(p(HGNC:IDE)) |
| pubmed:29626319 | a(CHEBI:"docosahexaenoic acid") increases act(p(HGNC:IDE)) |
| pubmed:29626319 | a(CHEBI:"docosahexaenoic acid") increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | a(CHEBI:"docosahexaenoic acid") increases act(a(MESH:Erythrocytes)) |
| pubmed:29626319 | a(CHEBI:atorvastatin) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | a(CHEBI:atorvastatin) increases bp(GO:"ERK1 and ERK2 cascade") |
| pubmed:29626319 | a(CHEBI:atorvastatin) increases tloc(p(HGNC:MME), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:29626319 | a(CHEBI:nobiletin) increases act(p(HGNC:MME)) |
| pubmed:29626319 | a(CHEBI:nobiletin) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | a(CHEBI:"ginsenoside Rg1") increases act(p(HGNC:MME)) |
| pubmed:29626319 | a(CHEBI:"ginsenoside Rg1") decreases path(MESH:Tauopathies) |
| pubmed:29626319 | a(MESH:"Granulocyte Colony-Stimulating Factor") increases act(p(HGNC:MME)) |
| pubmed:29626319 | a(MESH:"Granulocyte Colony-Stimulating Factor") decreases path(MESH:Tauopathies) |
| pubmed:29626319 | p(HGNC:ANXA1) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | p(HGNC:ANXA1) increases act(p(HGNC:MME)) |
| pubmed:29626319 | complex(a(MESH:"Chemokine CX3CL1"), p(HGNC:CX3CR1)) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | p(HGNC:CD36) increases deg(a(CHEBI:amyloid-beta)) |
| pubmed:29626319 | a(CHEBI:"disodium cromoglycate") decreases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | a(CHEBI:oleocanthal) decreases a(CHEBI:amyloid-beta) |
| pubmed:29626319 | a(CHEBI:oleocanthal) increases p(HGNC:LRP1) |
| pubmed:29626319 | a(CHEBI:oleocanthal) increases p(HGNC:ABCB1) |
| pubmed:29238289 | complex(p(HGNC:MAPT), p(MESH:"Receptors, Muscarinic")) increases a(MESH:Calcium) |
| pubmed:29238289 | complex(p(HGNC:MAPT), p(MESH:"Receptors, Muscarinic")) increases bp(GO:"apoptotic process") |
| pubmed:29238289 | complex(p(HGNC:HSPA8), p(INTERPRO:"Chaperone DnaJ")) regulates tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:29238289 | p(HGNC:SNAP23) increases tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:29238289 | p(HGNC:SNAP23) isA p(MESH:"SNARE Proteins") |
| pubmed:29238289 | p(MESH:"SNARE Proteins") increases bp(GO:exocytosis) |
| pubmed:29238289 | p(MESH:"rab GTP-Binding Proteins") regulates act(a(MESH:"Transport Vesicles")) |
| pubmed:29238289 | p(MESH:"rab GTP-Binding Proteins") regulates bp(MESH:"Membrane Fusion") |
| pubmed:29980653 | p(HGNC:PRNP, var("?")) positiveCorrelation path(MESH:"Prion Diseases") |
| pubmed:29980653 | complex(a(CONSO:"protein aggregates"), p(HGNCGENEFAMILY:Syndecans)) increases path(CONSO:Neurodegeneration) |
| pubmed:29980653 | a(MESH:Glycosaminoglycans) association p(HGNCGENEFAMILY:Syndecans) |
| pubmed:29980653 | complex(a(CONSO:"Tau aggregates"), a(MESH:Glycosaminoglycans)) increases a(CONSO:"Tau fibrils") |
| pubmed:29980653 | complex(a(CONSO:"6-O-sulfated heparin"), a(CONSO:"Tau aggregates")) increases a(CONSO:"Tau fibrils") |
| pubmed:29980653 | complex(a(CONSO:"Tau aggregates"), p(HGNCGENEFAMILY:Syndecans, pmod(go:0006477 ! "protein sulfation"))) increases a(CONSO:"Tau fibrils") |
| pubmed:17493042 | p(CONSO:"tubulin-binding repeat 2") partOf p(CONSO:"microtubule-binding region") |
| pubmed:17493042 | p(CONSO:"tubulin-binding repeat 2") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat") |
| pubmed:17493042 | p(CONSO:"tubulin-binding repeat 2") equivalentTo p(CONSO:"Tau isoform F (441 aa)", frag("275_305")) |
| pubmed:23407988 | p(CONSO:"tubulin-binding repeat 2") partOf p(CONSO:"4R tau") |
| pubmed:23407988 | p(CONSO:"tubulin-binding repeat 2") partOf p(CONSO:"3R tau") |
| pubmed:2123288 | p(CONSO:"tubulin-binding repeat 2") association p(FPLX:CALM) |
| pubmed:17493042 | p(CONSO:"tubulin-binding repeat 3") partOf p(CONSO:"microtubule-binding region") |
| pubmed:17493042 | p(CONSO:"tubulin-binding repeat 3") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat") |
| pubmed:17493042 | p(CONSO:"tubulin-binding repeat 3") equivalentTo p(CONSO:"Tau isoform F (441 aa)", frag("306_336")) |
| pubmed:23407988 | p(CONSO:"tubulin-binding repeat 3") partOf p(CONSO:"4R tau") |
| pubmed:23407988 | p(CONSO:"tubulin-binding repeat 3") partOf p(CONSO:"3R tau") |
| pubmed:17493042 | p(CONSO:"tubulin-binding repeat 4") partOf p(CONSO:"microtubule-binding region") |
| pubmed:17493042 | p(CONSO:"tubulin-binding repeat 4") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat") |
| pubmed:17493042 | p(CONSO:"tubulin-binding repeat 4") equivalentTo p(CONSO:"Tau isoform F (441 aa)", frag("337_368")) |
| pubmed:17493042 | p(CONSO:"tubulin-binding repeat 4") directlyIncreases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) |
| pubmed:23407988 | p(CONSO:"tubulin-binding repeat 4") partOf p(CONSO:"4R tau") |
| pubmed:17493042 | p(INTERPRO:"MAP2/Tau projection") equivalentTo p(CONSO:"projection domain") |
| pubmed:8391280 | p(INTERPRO:"MAP2/Tau projection") association p(HGNC:DCTN1) |
| pubmed:12551948 | p(INTERPRO:"MAP2/Tau projection") decreases bp(GO:"neuron projection development") |
| pubmed:12551948 | p(INTERPRO:"MAP2/Tau projection") isA p(HGNC:MAPT, loc(GO:"plasma membrane")) |
| pubmed:17493042 | p(CONSO:"Tau isoform F (441 aa)", frag("244_274")) equivalentTo p(CONSO:"tubulin-binding repeat 1") |
| pubmed:17493042 | p(CONSO:"Tau isoform F (441 aa)", frag("275_305")) equivalentTo p(CONSO:"tubulin-binding repeat 2") |
| pubmed:17493042 | p(CONSO:"Tau isoform F (441 aa)", frag("306_336")) equivalentTo p(CONSO:"tubulin-binding repeat 3") |
| pubmed:17493042 | p(CONSO:"Tau isoform F (441 aa)", frag("337_368")) equivalentTo p(CONSO:"tubulin-binding repeat 4") |
| pubmed:17493042 | p(HGNC:MAPT, frag("199_370")) equivalentTo p(CONSO:"microtubule-binding region") |
| pubmed:17493042 | p(HGNC:MAPT, frag("1_198")) equivalentTo p(CONSO:"projection domain") |
| pubmed:17493042 | p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat", pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) |
| pubmed:17493042 | p(FPLX:PRKG) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) |
| pubmed:17493042 | bp(MESH:Mitosis) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) |
| pubmed:21757739 | p(CONSO:"assembly domain") equivalentTo p(HGNC:MAPT, frag("199_441")) |
| pubmed:21757739 | p(HGNC:MAPT, frag("199_441")) equivalentTo p(CONSO:"assembly domain") |
| pubmed:21757739 | p(HGNC:MAPT, frag("244_369")) equivalentTo p(CONSO:"microtubule-binding region") |
| pubmed:21757739 | p(HGNC:MAPT, frag("370_441")) partOf p(CONSO:"assembly domain") |
| pubmed:21757739 | p(CONSO:"proline-rich region 2") equivalentTo p(HGNC:MAPT, frag("199_244")) |
| pubmed:21757739 | p(CONSO:"proline-rich region 2") partOf p(CONSO:"assembly domain") |
| pubmed:21757739 | p(CONSO:"proline-rich region 2") partOf p(CONSO:"proline-rich domain") |
| pubmed:21757739 | p(HGNC:MAPT, frag("199_244")) equivalentTo p(CONSO:"proline-rich region 2") |
| pubmed:21757739 | p(CONSO:"proline-rich domain") equivalentTo p(INTERPRO:"PSP, proline-rich") |
| pubmed:22033876 | p(CONSO:"proline-rich domain") regulates complex(p(FPLX:Actin), p(HGNC:MAPT)) |
| pubmed:22033876 | p(CONSO:"proline-rich domain") regulates complex(p(HGNC:MAPT), p(INTERPRO:"SH3 domain")) |
| pubmed:22033876 | p(CONSO:"proline-rich domain") regulates complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:"Src family tyrosine kinases")) |
| pubmed:22033876 | p(CONSO:"proline-rich domain") regulates complex(p(HGNC:MAPT), p(HGNC:PLCG1)) |
| pubmed:21757739 | p(INTERPRO:"PSP, proline-rich") equivalentTo p(CONSO:"proline-rich domain") |
| pubmed:21757739 | p(CONSO:"proline-rich region 1") equivalentTo p(HGNC:MAPT, frag("152_198")) |
| pubmed:21757739 | p(CONSO:"proline-rich region 1") partOf p(CONSO:"proline-rich domain") |
| pubmed:21757739 | p(CONSO:"proline-rich region 1") partOf p(CONSO:"projection domain") |
| pubmed:21757739 | p(HGNC:MAPT, frag("152_198")) equivalentTo p(CONSO:"proline-rich region 1") |
| pubmed:21757739 | p(HGNC:MAPT, frag("1_151")) partOf p(CONSO:"projection domain") |
| pubmed:27260836 | complex(p(CONSO:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) positiveCorrelation bp(GO:"clathrin-dependent endocytosis") |
| pubmed:27260836 | p(HGNC:AP2M1) partOf p(CONSO:"AP-2 complex") |
| pubmed:27260836 | p(HGNC:AP2B1) partOf p(CONSO:"AP-2 complex") |
| pubmed:27260836 | p(HGNC:AP2A1) partOf p(CONSO:"AP-2 complex") |
| pubmed:27260836 | p(HGNC:AP2A2) partOf p(CONSO:"AP-2 complex") |
| pubmed:27260836 | p(HGNC:AP2S1) partOf p(CONSO:"AP-2 complex") |
| pubmed:27260836 | complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:PICALM)) partOf complex(GO:"neurofibrillary tangle") |
| pubmed:27260836 | complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:PICALM)) partOf complex(GO:"neurofibrillary tangle") |
| pubmed:27260836 | complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:PICALM)) partOf complex(GO:"Pick body") |
| pubmed:27260836 | complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:PICALM)) partOf complex(GO:"Cajal body") |
| pubmed:27260836 | complex(GO:"Pick body") positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pubmed:24368848 | p(CONSO:"Tau isoform F (441 aa)", var("p.Pro301Leu")) increases path(MESH:"Frontotemporal Dementia") |
| pubmed:23407988 | a(CONSO:"ghost tangles") decreases complex(GO:"dendritic tree") |
| pubmed:23407988 | a(CONSO:"Brodmann (1909) area 36") positiveCorrelation p(CONSO:"4R tau") |
| pubmed:23407988 | a(CONSO:"CA1 field of hippocampus") positiveCorrelation p(CONSO:"4R tau") |
| pubmed:23407988 | a(CONSO:"CA2 field of hippocampus") positiveCorrelation p(CONSO:"4R tau") |
| pubmed:23407988 | a(CONSO:"CA3 field of hippocampus") positiveCorrelation p(CONSO:"4R tau") |
| pubmed:23407988 | a(CONSO:"CA4 field of hippocampus") positiveCorrelation p(CONSO:"4R tau") |
| pubmed:23407988 | act(complex(GO:dendrite)) positiveCorrelation complex(GO:"dendritic tree") |
| pubmed:22253473 | a(MESH:Neuropil) positiveCorrelation p(CONSO:"Tau epitope, AT8") |
| pubmed:23407988 | complex(GO:"dendritic tree") positiveCorrelation act(complex(GO:dendrite)) |
| pubmed:22142809 | p(CONSO:RAC1b) association p(HGNC:NGFR) |
| pubmed:22142809 | p(CONSO:RAC1b) isA p(HGNC:RAC1) |
| pubmed:22142809 | p(CONSO:RAC1b) negativeCorrelation p(HGNC:CAV2) |
| pubmed:22142809 | p(CONSO:RAC1b) negativeCorrelation p(HGNC:GNB4) |
| pubmed:22142809 | p(CONSO:RAC1b) negativeCorrelation p(HGNC:LIPA) |
| pubmed:22142809 | p(CONSO:RAC1b) positiveCorrelation a(CONSO:"cerebral cortex") |
| pubmed:27087442 | act(p(CONSO:RAC1b)) decreases bp(GO:"neuron death") |
| pubmed:22142809 | p(HGNC:CAV2) negativeCorrelation p(CONSO:RAC1b) |
| pubmed:22142809 | p(HGNC:CAV2) association bp(GO:"regulation of cell cycle") |
| pubmed:22142809 | p(HGNC:CAV2) association bp(GO:"lipid metabolic process") |
| pubmed:22142809 | p(HGNC:GNB4) negativeCorrelation p(CONSO:RAC1b) |
| pubmed:22142809 | p(HGNC:GNB4) association bp(GO:"regulation of cell cycle") |
| pubmed:22142809 | a(CONSO:"cerebral cortex") positiveCorrelation p(CONSO:RAC1b) |
| pubmed:1918161 | p(HGNC:MAPT, frag("237_367")) directlyIncreases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) |
| pubmed:1918161 | p(HGNC:MAPT, frag("237_367")) equivalentTo p(CONSO:"microtubule-binding region") |
| pubmed:1918161 | complex(GO:axon) positiveCorrelation p(HGNC:MAPT) |
| pubmed:26671985 | act(complex(GO:axon)) negativeCorrelation p(CONSO:"phosphatase-activating domain") |
| pubmed:26671985 | act(complex(GO:axon)) negativeCorrelation path(CONSO:neurotoxicity) |
| pubmed:1918161 | complex(GO:"neuron projection") positiveCorrelation p(HGNC:MAPT) |
| pubmed:17187063 | p(CONSO:"Tau isoform F (441 aa)", var("p.Val337Met")) increases path(CONSO:Neurodegeneration) |
| pubmed:6543144 | complex(GO:neurofilament) association p(HGNC:MAPT) |
| pubmed:6543144 | complex(complex(GO:neurofilament), p(HGNC:MAPT)) association complex(GO:microtubule) |
| pubmed:11812770 | complex(p(HGNC:GSK3B), p(HGNC:MAPT)) positiveCorrelation p(HGNC:GSK3B) |
| pubmed:11812770 | complex(p(HGNC:GSK3B), p(HGNC:MAPT)) positiveCorrelation p(HGNC:MAPT) |
| pubmed:18680553 | p(RGD:Mapt, frag("223_226")) association p(HGNC:FYN) |
| pubmed:18467332 | p(HGNC:SRC, frag("84_145")) association p(HGNC:MAPT) |
| pubmed:18467332 | p(HGNC:SRC, frag("84_145")) equivalentTo p(INTERPRO:"SH3 domain") |
| pubmed:18467332 | p(INTERPRO:"SH3 domain") equivalentTo p(HGNC:SRC, frag("84_145")) |
| pubmed:18467332 | p(INTERPRO:"SH3 domain") equivalentTo p(HGNC:PLCG1, frag("790_851")) |
| pubmed:18467332 | p(HGNC:PLCG1, frag("790_851")) association p(HGNC:MAPT) |
| pubmed:18467332 | p(HGNC:PLCG1, frag("790_851")) equivalentTo p(INTERPRO:"SH3 domain") |
| pubmed:18467332 | p(HGNC:GRB2, frag("1_57")) association p(HGNC:MAPT) |
| pubmed:18467332 | p(HGNC:GRB2, frag("1_57")) isA complex(p(HGNC:GRB2), p(HGNC:MAPT)) |
| pubmed:18467332 | p(HGNC:GRB2, frag("1_57")) equivalentTo p(INTERPRO:"GRB2, N-terminal SH3 domain") |
| pubmed:18467332 | complex(p(HGNC:GRB2), p(HGNC:MAPT)) association p(HGNC:MAPT) |
| pubmed:18467332 | p(INTERPRO:"GRB2, N-terminal SH3 domain") equivalentTo p(HGNC:GRB2, frag("1_57")) |
| pubmed:18467332 | p(HGNC:PIK3R1, frag("3_79")) association p(HGNC:MAPT) |
| pubmed:18467332 | p(HGNC:PIK3R1, frag("3_79")) equivalentTo p(INTERPRO:"Phosphatidylinositol 3-kinase regulatory subunit alpha, SH3 domain") |
| pubmed:18467332 | p(INTERPRO:"Phosphatidylinositol 3-kinase regulatory subunit alpha, SH3 domain") equivalentTo p(HGNC:PIK3R1, frag("3_79")) |
| pubmed:19491104 | p(MGI:Mapk8ip1) association p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) |
| pubmed:19491104 | act(p(MGI:Mapk8ip1)) negativeCorrelation p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) |
| pubmed:19491104 | act(p(MGI:Klc1)) negativeCorrelation p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) |
| pubmed:19491104 | complex(p(MGI:Klc1), p(MGI:Mapk8ip1)) negativeCorrelation p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) |
| pubmed:10464280 | rxn(reactants(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:18500754 | complex(p(HGNC:MAPT), p(INTERPRO:"Heat shock protein 70 family")) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) |
| pubmed:18500754 | p(INTERPRO:"Heat shock protein 70kD, C-terminal domain superfamily") association p(CONSO:"microtubule-binding region") |
| pubmed:19363271 | a(CHEBI:juglone) increases bp(GO:"neurofibrillary tangle assembly") |
| pubmed:14612456 | complex(p(HGNC:HSPA8), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:STUB1), p(HGNC:UBE2D2)) directlyIncreases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:8391280 | p(FPLX:Ubiquitin) association p(CONSO:"microtubule-binding region") |
| pubmed:8391280 | p(FPLX:Ubiquitin) directlyIncreases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:8391280 | act(p(INTERPRO:"Dynein associated protein")) positiveCorrelation complex(a(MESH:Microtubules), p(INTERPRO:"Dynein associated protein")) |
| pubmed:8391280 | complex(a(MESH:Microtubules), p(INTERPRO:"Dynein associated protein")) positiveCorrelation act(p(INTERPRO:"Dynein associated protein")) |
| pubmed:8391280 | g(DBSNP:rs63750424) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pubmed:8391280 | g(DBSNP:rs63750424) negativeCorrelation complex(p(HGNC:DCTN1), p(HGNC:MAPT)) |
| pubmed:16176937 | p(RGD:Klc1) isA complex(p(RGD:Klc1), p(RGD:Mapt)) |
| pubmed:16176937 | p(RGD:Klc1) isA p(INTERPRO:"Kinesin motor domain") |
| pubmed:16176937 | p(RGD:Klc2) isA complex(p(RGD:Klc2), p(RGD:Mapt)) |
| pubmed:16176937 | p(RGD:Klc2) isA p(INTERPRO:"Kinesin motor domain") |
| pubmed:16176937 | p(INTERPRO:"Kinesin motor domain") association p(RGD:Snca) |
| pubmed:16176937 | p(RGD:Snca) isA complex(p(FPLX:"Cytoplasmic_dynein"), p(RGD:Snca)) |
| pubmed:16176937 | p(RGD:Snca) association p(INTERPRO:"Kinesin motor domain") |
| pubmed:16176937 | p(RGD:Snca) decreases complex(p(RGD:Klc2), p(RGD:Snca)) |
| pubmed:16176937 | p(FPLX:"Cytoplasmic_dynein") isA complex(p(FPLX:"Cytoplasmic_dynein"), p(RGD:Snca)) |
| pubmed:10391244 | p(HGNC:PIN1, frag("5_39")) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:10391244 | act(p(HGNC:PIN1, frag("5_39"))) positiveCorrelation complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)), p(HGNC:PIN1, frag("5_39"))) |
| pubmed:10391244 | complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)), p(HGNC:PIN1, frag("5_39"))) positiveCorrelation act(p(HGNC:PIN1, frag("5_39"))) |
| pubmed:10391244 | complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)), p(HGNC:PIN1, frag("5_39"))) association complex(GO:"neurofibrillary tangle") |
| pubmed:10391244 | complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)), p(HGNC:PIN1, frag("5_39"))) increases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) |
| pubmed:10391244 | p(HGNC:PIN1, var("p.Tyr23Ala")) decreases act(p(HGNC:PIN1, frag("5_39"))) |
| pubmed:10391244 | p(HGNC:PIN1, var("p.Tyr23Ala")) decreases complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)), p(HGNC:PIN1, frag("5_39"))) |
| pubmed:20133804 | p(RGD:Fkbp4) positiveCorrelation p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:20133804 | p(RGD:Fkbp4) isA complex(p(RGD:Fkbp4), p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:20133804 | p(RGD:Fkbp4) decreases act(p(RGD:Mapt)) |
| pubmed:20133804 | p(RGD:Fkbp4) negativeCorrelation bp(GO:"neuron projection development") |
| pubmed:20133804 | p(HGNC:FKBP4, frag("270_386")) association p(FPLX:HSP90) |
| pubmed:20133804 | p(HGNC:FKBP4, frag("270_386")) isA p(HGNC:FKBP4) |
| pubmed:20133804 | p(HGNC:FKBP4, frag("270_386")) isA complex(p(FPLX:HSP90), p(HGNC:FKBP4)) |
| pubmed:20071522 | complex(p(HGNC:AHSA1), p(HGNC:MAPT)) negativeCorrelation p(HGNC:FKBP5) |
| pubmed:20071522 | p(HGNC:FKBP5, var("p.Phe130Ala")) increases bp(GO:"microtubule polymerization") |
| pubmed:20071522 | p(HGNC:FKBP4, var("p.Phe130Ala")) increases bp(GO:"microtubule polymerization") |
| pubmed:2123288 | p(FPLX:CALM) association p(CONSO:"tubulin-binding repeat 2") |
| pubmed:2123288 | act(p(FPLX:CALM)) increases complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM)) |
| pubmed:2123288 | act(p(FPLX:CALM)) decreases bp(GO:"microtubule polymerization") |
| pubmed:2123288 | complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM)) isA complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) |
| pubmed:2123288 | complex(p(FPLX:CALM), p(HGNC:MAPT)) isA complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) |
| pubmed:2123288 | complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) negativeCorrelation act(p(HGNC:MAPT)) |
| pubmed:2833519 | p(HGNC:S100B) association p(HGNC:MAPT) |
| pubmed:2833519 | p(HGNC:S100B) isA complex(p(HGNC:MAPT), p(HGNC:S100B)) |
| pubmed:2833519 | act(p(HGNC:S100B)) decreases act(p(FPLX:"CAMK2_family")) |
| pubmed:18494933 | p(HGNC:S100B) increases act(p(HGNC:AGER)) |
| pubmed:18494933 | p(HGNC:S100B) increases act(p(FPLX:JNK)) |
| pubmed:18494933 | p(HGNC:S100B) increases act(p(FPLX:JNK)) |
| pubmed:18494933 | p(HGNC:S100B) increases p(GO:"neurofibrillary tangle") |
| pubmed:18494933 | p(HGNC:S100B) positiveCorrelation bp(GO:"inflammatory response") |
| pubmed:18494933 | p(HGNC:S100B) decreases bp(GO:"Wnt signaling pathway") |
| pubmed:18494933 | p(HGNC:S100B) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:2833519 | complex(p(HGNC:MAPT), p(HGNC:S100B)) decreases act(p(FPLX:"CAMK2_family")) |
| pubmed:18494933 | p(MESH:"beta Catenin") regulates bp(GO:"Wnt signaling pathway") |
| pubmed:18494933 | p(MESH:"beta Catenin") decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:12714745 | g(DBSNP:rs104893877) positiveCorrelation p(CONSO:"alpha-synuclein fibrils") |
| pubmed:12714745 | g(DBSNP:rs104893877) positiveCorrelation complex(GO:"neurofibrillary tangle") |
| pubmed:12714745 | g(DBSNP:rs104893877) positiveCorrelation complex(GO:"Lewy body") |
| pubmed:12714745 | complex(GO:"Lewy body") positiveCorrelation g(DBSNP:rs104893877) |
| pubmed:12714745 | composite(p(HGNC:MAPT), p(HGNC:SNCA)) increases p(CONSO:"alpha-synuclein fibrils") |
| pubmed:12714745 | composite(p(HGNC:MAPT), p(HGNC:SNCA)) increases p(CONSO:"Tau fibrils") |
| pubmed:21339331 | p(CONSO:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:21339331 | p(CONSO:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) |
| pubmed:21339331 | p(CONSO:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:21339331 | p(CONSO:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:21339331 | p(CONSO:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases complex(p(HGNC:ANXA2), p(HGNC:MAPT)) |
| pubmed:21339331 | p(HGNC:ANXA2) association p(HGNC:MAPT) |
| pubmed:21339331 | p(HGNC:ANXA2) isA complex(p(HGNC:ANXA2), p(HGNC:MAPT)) |
| pubmed:18096814 | a(CHEBI:"2-bromohexadecanoic acid") decreases p(MGI:Fyn, pmod(go:0018345 ! "protein palmitoylation")) |
| pubmed:18096814 | a(CHEBI:"2-bromohexadecanoic acid") negativeCorrelation p(MGI:Mapt, loc(GO:"membrane raft")) |
| pubmed:18096814 | a(CHEBI:"2-bromohexadecanoic acid") negativeCorrelation p(MGI:Fyn, loc(GO:"membrane raft")) |
| pubmed:18096814 | p(MGI:Fyn, pmod(go:0018345 ! "protein palmitoylation")) increases tloc(p(MGI:Fyn), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) |
| pubmed:21131359 | bp(MESH:"Hot Temperature") increases complex(a(CHEBI:"double-stranded DNA"), p(HGNC:MAPT)) |
| pubmed:21131359 | bp(MESH:"Hot Temperature") increases tloc(p(HGNC:MAPT), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pubmed:21131359 | bp(MESH:"Hot Temperature") negativeCorrelation p(HGNC:MAPT) |
| pubmed:21131359 | bp(MESH:"Hot Temperature") decreases a(CHEBI:"double-stranded DNA") |
| pubmed:8226987 | bp(MESH:"Hot Temperature") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:19732809 | bp(MESH:"Hot Temperature") association p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:21131359 | a(CHEBI:"double-stranded DNA") isA complex(a(CHEBI:"double-stranded DNA"), p(HGNC:MAPT)) |
| pubmed:21131359 | a(CHEBI:"double-stranded DNA") association p(HGNC:MAPT) |
| pubmed:8985176 | a(CHEBI:"transfer RNA") increases bp(GO:"neurofibrillary tangle assembly") |
| pubmed:28173111 | r(MGI:Dnm1l) positiveCorrelation path(CONSO:"mitochondrial dysfunction") |
| pubmed:28173111 | r(MGI:Dnm1l) negativeCorrelation act(complex(GO:mitochondrion)) |
| pubmed:28173111 | r(MGI:Dnm1l) negativeCorrelation complex(GO:mitochondrion) |
| pubmed:28173111 | r(MGI:Dnm1l) positiveCorrelation p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28173111 | r(MGI:Dnm1l) negativeCorrelation bp(MESH:"Mitochondrial Dynamics") |
| pubmed:28173111 | r(MGI:Dnm1l) negativeCorrelation act(complex(GO:"neuron to neuron synapse")) |
| pubmed:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Syp) |
| pubmed:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Dlg4) |
| pubmed:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Syn1) |
| pubmed:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Vamp1) |
| pubmed:28173111 | r(MGI:Dnm1l) negativeCorrelation r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") |
| pubmed:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Synpo) |
| pubmed:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Nrgn) |
| pubmed:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Gap43) |
| pubmed:28173111 | r(MGI:Dnm1l) positiveCorrelation r(MGI:Fis1) |
| pubmed:28173111 | r(MGI:Dnm1l) positiveCorrelation r(MGI:Ppid) |
| pubmed:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Mfn1) |
| pubmed:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Mfn2) |
| pubmed:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Opa1) |
| pubmed:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Nrf1) |
| pubmed:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Nfe2l2) |
| pubmed:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Ppargc1a) |
| pubmed:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Tfam) |
| pubmed:28173111 | act(complex(GO:mitochondrion)) negativeCorrelation r(MGI:Dnm1l) |
| pubmed:28173111 | complex(GO:mitochondrion) negativeCorrelation r(MGI:Dnm1l) |
| pubmed:28173111 | complex(GO:mitochondrion) association p(MGI:Nrf1) |
| pubmed:28173111 | complex(GO:mitochondrion) association p(MGI:Nfe2l2) |
| pubmed:28173111 | complex(GO:mitochondrion) association p(MGI:Ppargc1a) |
| pubmed:28173111 | complex(GO:mitochondrion) association p(MGI:Tfam) |
| pubmed:28173111 | act(complex(GO:"neuron to neuron synapse")) negativeCorrelation r(MGI:Dnm1l) |
| pubmed:28173111 | act(complex(GO:"neuron to neuron synapse")) association p(MGI:Syp) |
| pubmed:28173111 | act(complex(GO:"neuron to neuron synapse")) association p(MGI:Dlg4) |
| pubmed:28173111 | act(complex(GO:"neuron to neuron synapse")) association p(MGI:Syn1) |
| pubmed:28173111 | act(complex(GO:"neuron to neuron synapse")) association p(MGI:Vamp1) |
| pubmed:28173111 | act(complex(GO:"neuron to neuron synapse")) association p(HGNCGENEFAMILY:"Vesicle associated membrane proteins") |
| pubmed:28173111 | act(complex(GO:"neuron to neuron synapse")) association p(MGI:Synpo) |
| pubmed:28173111 | act(complex(GO:"neuron to neuron synapse")) association p(MGI:Nrgn) |
| pubmed:28173111 | act(complex(GO:"neuron to neuron synapse")) association p(MGI:Gap43) |
| pubmed:28173111 | r(MGI:Syp) negativeCorrelation r(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Dnm1l) negativeCorrelation p(MGI:Syp) |
| pubmed:28173111 | p(MGI:Dnm1l) negativeCorrelation p(MGI:Dlg4) |
| pubmed:28173111 | p(MGI:Dnm1l) negativeCorrelation p(MGI:Syn1) |
| pubmed:28173111 | p(MGI:Dnm1l) negativeCorrelation p(MGI:Vamp1) |
| pubmed:28173111 | p(MGI:Dnm1l) negativeCorrelation p(HGNCGENEFAMILY:"Vesicle associated membrane proteins") |
| pubmed:28173111 | p(MGI:Dnm1l) negativeCorrelation p(MGI:Synpo) |
| pubmed:28173111 | p(MGI:Dnm1l) negativeCorrelation p(MGI:Nrgn) |
| pubmed:28173111 | p(MGI:Dnm1l) negativeCorrelation p(MGI:Gap43) |
| pubmed:28173111 | p(MGI:Dnm1l) positiveCorrelation p(MGI:Fis1) |
| pubmed:28173111 | p(MGI:Dnm1l) association bp(GO:"mitochondrial fission") |
| pubmed:28173111 | p(MGI:Dnm1l) positiveCorrelation p(MGI:Ppid) |
| pubmed:28173111 | p(MGI:Dnm1l) negativeCorrelation p(MGI:Mfn1) |
| pubmed:28173111 | p(MGI:Dnm1l) negativeCorrelation p(MGI:Mfn2) |
| pubmed:28173111 | p(MGI:Dnm1l) negativeCorrelation p(MGI:Opa1) |
| pubmed:28173111 | p(MGI:Dnm1l) negativeCorrelation p(MGI:Nrf1) |
| pubmed:28173111 | p(MGI:Dnm1l) negativeCorrelation p(MGI:Nfe2l2) |
| pubmed:28173111 | p(MGI:Dnm1l) negativeCorrelation p(MGI:Ppargc1a) |
| pubmed:28173111 | p(MGI:Dnm1l) negativeCorrelation p(MGI:Tfam) |
| pubmed:28173111 | r(MGI:Dlg4) negativeCorrelation r(MGI:Dnm1l) |
| pubmed:28173111 | r(MGI:Syn1) negativeCorrelation r(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Syn1) negativeCorrelation p(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Syn1) association act(complex(GO:"neuron to neuron synapse")) |
| pubmed:28173111 | r(MGI:Vamp1) negativeCorrelation r(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Vamp1) negativeCorrelation p(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Vamp1) association act(complex(GO:"neuron to neuron synapse")) |
| pubmed:28173111 | r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") negativeCorrelation r(MGI:Dnm1l) |
| pubmed:28173111 | p(HGNCGENEFAMILY:"Vesicle associated membrane proteins") negativeCorrelation p(MGI:Dnm1l) |
| pubmed:28173111 | p(HGNCGENEFAMILY:"Vesicle associated membrane proteins") association act(complex(GO:"neuron to neuron synapse")) |
| pubmed:28173111 | r(MGI:Synpo) negativeCorrelation r(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Synpo) negativeCorrelation p(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Synpo) association act(complex(GO:"neuron to neuron synapse")) |
| pubmed:28173111 | r(MGI:Nrgn) negativeCorrelation r(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Nrgn) negativeCorrelation p(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Nrgn) association act(complex(GO:"neuron to neuron synapse")) |
| pubmed:28173111 | r(MGI:Gap43) negativeCorrelation r(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Gap43) negativeCorrelation p(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Gap43) association act(complex(GO:"neuron to neuron synapse")) |
| pubmed:28173111 | r(MGI:Fis1) positiveCorrelation r(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Fis1) positiveCorrelation p(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Fis1) association bp(GO:"mitochondrial fission") |
| pubmed:28173111 | r(MGI:Ppid) positiveCorrelation r(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Ppid) positiveCorrelation p(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Ppid) association complex(GO:"mitochondrial matrix") |
| pubmed:28173111 | complex(GO:"mitochondrial matrix") association p(MGI:Ppid) |
| pubmed:28173111 | r(MGI:Mfn1) negativeCorrelation r(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Mfn1) negativeCorrelation p(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Mfn1) association bp(GO:"mitochondrial fusion") |
| pubmed:28173111 | r(MGI:Mfn2) negativeCorrelation r(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Mfn2) negativeCorrelation p(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Mfn2) association bp(GO:"mitochondrial fusion") |
| pubmed:28173111 | r(MGI:Opa1) negativeCorrelation r(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Opa1) negativeCorrelation p(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Opa1) association bp(GO:"mitochondrial fusion") |
| pubmed:28173111 | r(MGI:Nrf1) negativeCorrelation r(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Nrf1) negativeCorrelation p(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Nrf1) association complex(GO:mitochondrion) |
| pubmed:28173111 | r(MGI:Nfe2l2) negativeCorrelation r(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Nfe2l2) negativeCorrelation p(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Nfe2l2) association complex(GO:mitochondrion) |
| pubmed:29121589 | p(MGI:Nfe2l2) decreases bp(GO:"inflammatory response") |
| pubmed:28173111 | r(MGI:Ppargc1a) negativeCorrelation r(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Ppargc1a) negativeCorrelation p(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Ppargc1a) association complex(GO:mitochondrion) |
| pubmed:25987199 | act(p(MGI:Ppargc1a)) positiveCorrelation act(a(GO:mitochondrion)) |
| pubmed:28173111 | r(MGI:Tfam) negativeCorrelation r(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Tfam) negativeCorrelation p(MGI:Dnm1l) |
| pubmed:28173111 | p(MGI:Tfam) association complex(GO:mitochondrion) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Asp13*")) partOf a(GO:"neurofibrillary tangle") |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Asp13*")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Asp13*")) isA p(HGNC:MAPT) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Asp25*")) partOf a(GO:"neurofibrillary tangle") |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Asp25*")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Asp368*")) partOf a(GO:"neurofibrillary tangle") |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Asp368*")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Ala2*")) isA p(HGNC:MAPT) |
| pubmed:25974414 | p(HGNC:MAPT, pmod(CONSO:polyamination, Gln, 6)) isA p(HGNC:MAPT) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Ala103*")) isA p(HGNC:MAPT) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Gln124*")) isA p(HGNC:MAPT) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Gln124*")) increases p(FPLX:Tubulin, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Gln124*")) increases p(INTERPRO:"Alpha tubulin", pmod(CONSO:detyrosination)) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Gln124*")) positiveCorrelation act(p(HGNC:VASH1)) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Gln124*")) positiveCorrelation act(p(HGNC:VASH2)) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Met127*")) isA p(HGNC:MAPT) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Pro172*")) isA p(HGNC:MAPT) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Lys174*")) isA p(HGNC:MAPT) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Lys224*")) isA p(HGNC:MAPT) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Ser238*")) isA p(HGNC:MAPT) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Lys240*")) isA p(HGNC:MAPT) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Lys259*")) isA p(HGNC:MAPT) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Gly261*")) isA p(HGNC:MAPT) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Lys280*")) isA p(HGNC:MAPT) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Val306*")) isA p(HGNC:MAPT) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Ile308*")) isA p(HGNC:MAPT) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Val309*")) isA p(HGNC:MAPT) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Lys311*")) isA p(HGNC:MAPT) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Lys331*")) isA p(HGNC:MAPT) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Lys395*")) isA p(HGNC:MAPT) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Met11*")) isA p(HGNC:MAPT) |
| pubmed:25974414 | p(HGNC:MAPT, var("p.Glu12*")) isA p(HGNC:MAPT) |
| pubmed:28002468 | p(FPLX:Tubulin) decreases p(HGNC:MAP2, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:25974414 | act(p(HGNC:VASH1)) positiveCorrelation p(HGNC:MAPT, var("p.Gln124*")) |
| pubmed:25974414 | act(p(HGNC:VASH1)) increases p(INTERPRO:"Alpha tubulin", pmod(CONSO:detyrosination)) |
| pubmed:25974414 | act(p(HGNC:VASH2)) positiveCorrelation p(HGNC:MAPT, var("p.Gln124*")) |
| pubmed:25974414 | act(p(HGNC:VASH2)) increases p(INTERPRO:"Alpha tubulin", pmod(CONSO:detyrosination)) |
| pubmed:25974414 | act(p(HGNC:TAOK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:16566606 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) decreases bp(GO:"tubulin complex assembly") |
| pubmed:16566606 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) association p(HGNC:MAPT, pmod(CONSO:misfolded)) |
| pubmed:22057784 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pubmed:22057784 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) positiveCorrelation path(CONSO:"Corticobasal Degeneration") |
| pubmed:22057784 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) partOf a(MESH:"Neuropil Threads") |
| pubmed:17050703 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) isA p(HGNC:MAPT, pmod(CONSO:nitration)) |
| pubmed:16566606 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) decreases bp(GO:"microtubule polymerization") |
| pubmed:16566606 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) positiveCorrelation a(CONSO:"paired helical filaments") |
| pubmed:16566606 | p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) negativeCorrelation act(p(HGNC:MAPT)) |
| pubmed:24869773 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 311)) association path(MESH:"Alzheimer Disease") |
| pubmed:24869773 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 311)) association p(CONSO:"Tau aggregates") |
| pubmed:24869773 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 259)) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:24869773 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 259)) isA p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys)) |
| pubmed:24869773 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 290)) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:24869773 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 290)) isA p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys)) |
| pubmed:22033876 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 290)) partOf p(CONSO:"tubulin-binding repeat 2") |
| pubmed:24869773 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 353)) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pubmed:24869773 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 353)) isA p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys)) |
| pubmed:24869773 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 24)) association p(HGNC:MAPT) |
| pubmed:24869773 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 24)) isA p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys)) |
| pubmed:24869773 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 44)) association p(HGNC:MAPT) |
| pubmed:24869773 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 44)) isA p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys)) |
| pubmed:24869773 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 67)) association p(HGNC:MAPT) |
| pubmed:24869773 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 67)) isA p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys)) |
| pubmed:24869773 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 190)) association p(HGNC:MAPT) |
| pubmed:24869773 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 190)) isA p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys)) |
| pubmed:22033876 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 163)) partOf p(CONSO:"proline-rich domain") |
| pubmed:22033876 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 174)) partOf p(CONSO:"proline-rich domain") |
| pubmed:22033876 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 180)) partOf p(CONSO:"proline-rich domain") |
| pubmed:10887109 | p(HGNCGENEFAMILY:"Src family tyrosine kinases") increases p(HGNC:PECAM1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22033876 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 254)) partOf p(CONSO:"tubulin-binding repeat 1") |
| pubmed:22033876 | p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 267)) partOf p(CONSO:"tubulin-binding repeat 1") |
| pubmed:23943618 | complex(p(FPLX:PPP2), p(HGNC:MAPT)) positiveCorrelation act(p(FPLX:PPP2)) |
| pubmed:23943618 | complex(p(FPLX:PPP2), p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22764226 | act(a(CHEBI:L-dopa)) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")) |
| pubmed:22764226 | act(a(CHEBI:L-dopa)) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")) |
| pubmed:22764226 | act(a(CHEBI:L-dopa)) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")) |
| pubmed:22764226 | act(a(CHEBI:L-dopa)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:22764226 | act(a(CHEBI:L-dopa)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:22764226 | act(a(CHEBI:L-dopa)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22764226 | act(a(CHEBI:L-dopa)) increases a(CHEBI:homocysteine) |
| pubmed:22764226 | act(a(CHEBI:L-dopa)) decreases p(MGI:Ppp2ca, pmod(go:0006479 ! "protein methylation")) |
| pubmed:22764226 | p(MGI:Ppp2ca, pmod(go:0006479 ! "protein methylation")) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:22764226 | p(MGI:Ppp2ca, pmod(go:0006479 ! "protein methylation")) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:25143394 | p(MGI:Ppp2ca) negativeCorrelation p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) |
| pubmed:25681682 | bp(MESH:"Body Mass Index") negativeCorrelation p(HGNC:AGER) |
| pubmed:24183963 | composite(a(CHEBI:glucose), a(PUBCHEM:16132389)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:24183963 | composite(a(CHEBI:glucose), a(PUBCHEM:16132389)) decreases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:24183963 | p(HGNC:GLP1R) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:24183963 | p(HGNC:GLP1R) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:25987199 | p(HGNC:GLP1R) decreases bp(MESH:"Oxidative Stress") |
| pubmed:25987199 | p(HGNC:GLP1R) increases act(a(GO:mitochondrion)) |
| pubmed:25987199 | p(HGNC:GLP1R) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:24183963 | a(CHEBI:exendin-4) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:24183963 | a(CHEBI:exendin-4) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) |
| pubmed:23531502 | complex(a(CHEBI:cinnamaldehydes), p(HGNC:MAPT)) decreases a(CONSO:"Tau aggregates") |
| pubmed:23531502 | a(CHEBI:cinnamaldehydes) decreases act(a(CHEBI:"hydrogen peroxide")) |
| pubmed:23531502 | a(CHEBI:cinnamaldehydes) decreases a(CONSO:"Tau aggregates") |
| pubmed:23531502 | complex(a(CHEBI:"(-)-epicatechin"), p(HGNC:MAPT)) decreases a(CONSO:"Tau aggregates") |
| pubmed:23531502 | a(CHEBI:"(-)-epicatechin") decreases act(a(CHEBI:"hydrogen peroxide")) |
| pubmed:23531502 | a(CHEBI:"(-)-epicatechin") decreases a(CONSO:"Tau aggregates") |
| pubmed:23531502 | a(CHEBI:"(-)-epicatechin") decreases a(CHEBI:acrolein) |
| pubmed:23531502 | composite(a(CHEBI:cinnamaldehydes), p(HGNC:MAPT)) causesNoChange bp(GO:"microtubule polymerization") |
| pubmed:23531502 | act(a(CHEBI:acrolein)) association a(GO:"neurofibrillary tangle") |
| pubmed:17082178 | a(CHEBI:acrolein) increases a(GO:"neurofibrillary tangle") |
| pubmed:23531502 | act(a(CHEBI:acrolein)) association path(MESH:"Plaque, Amyloid") |
| pubmed:23531502 | act(a(CHEBI:acrolein)) association a(CONSO:"dystrophic neurite") |
| pubmed:23531502 | act(a(CHEBI:acrolein)) increases bp(GO:"neuron death") |
| pubmed:23531502 | act(a(CHEBI:acrolein)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23531502 | act(a(CHEBI:acrolein)) increases act(p(HGNC:GSK3B)) |
| pubmed:23531502 | act(a(CHEBI:acrolein)) increases act(p(HGNC:MAPK14)) |
| pubmed:23531502 | act(a(CHEBI:acrolein)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:17082178 | a(CHEBI:acrolein) increases complex(p(HGNC:MAPT), p(HGNC:MAPT)) |
| pubmed:17082178 | a(CHEBI:acrolein) increases a(CONSO:"Tau oligomers") |
| pubmed:26655600 | p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:glycation)) increases a(CONSO:"Tau aggregates") |
| pubmed:26655600 | p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:glycation)) negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26655600 | p(CONSO:"Tau isoform C (410 aa)", pmod(CONSO:glycation)) increases a(CONSO:"Tau aggregates") |
| pubmed:26655600 | p(CONSO:"Tau isoform B (381 aa)", pmod(CONSO:glycation)) decreases a(CONSO:"Tau aggregates") |
| pubmed:26655600 | p(CONSO:"Tau isoform B (381 aa)", pmod(CONSO:glycation)) increases a(CONSO:"Tau aggregates") |
| pubmed:26655600 | p(CONSO:"Tau isoform F (441 aa)", pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:glycation)) |
| pubmed:26655600 | p(CONSO:"Tau isoform D (383 aa)", pmod(CONSO:glycation)) decreases a(CONSO:"Tau aggregates") |
| pubmed:26655600 | p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation")) decreases a(CONSO:"Tau aggregates") |
| pubmed:26655600 | p(CONSO:"Tau isoform E (412 aa)", pmod(CONSO:glycation)) decreases a(CONSO:"Tau aggregates") |
| pubmed:26655600 | p(CONSO:"Tau isoform E (412 aa)", pmod(go:0006468 ! "protein phosphorylation")) decreases a(CONSO:"Tau aggregates") |
| pubmed:26655600 | p(CONSO:"Tau isoform B (381 aa)", pmod(go:0006468 ! "protein phosphorylation")) increases a(CONSO:"Tau aggregates") |
| pubmed:26304819 | a(CHEBI:glyceraldehyde) increases r(HGNC:GAPDH) |
| pubmed:26304819 | a(CHEBI:glyceraldehyde) increases bp(GO:"apoptotic process") |
| pubmed:26304819 | a(CHEBI:glyceraldehyde) increases a(CONSO:GA-AGE) |
| pubmed:26304819 | a(CHEBI:glyceraldehyde) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:26304819 | a(CHEBI:glyceraldehyde) increases p(HGNC:MAPT) |
| pubmed:26304819 | a(CHEBI:glyceraldehyde) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) |
| pubmed:26304819 | a(CHEBI:glyceraldehyde) increases p(HGNC:VEGFA) |
| pubmed:26304819 | a(CHEBI:glyceraldehyde) increases p(HGNC:TGFB1) |
| pubmed:26304819 | r(HGNC:GAPDH) association bp(GO:"apoptotic process") |
| pubmed:26304819 | a(CONSO:GA-AGE) isA a(CHEBI:"advanced glycation end-product") |
| pubmed:26095350 | a(CHEBI:D-ribose) increases a(CHEBI:"advanced glycation end-product") |
| pubmed:26095350 | a(CHEBI:D-ribose) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) |
| pubmed:26095350 | a(CHEBI:D-ribose) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:26095350 | a(CHEBI:D-ribose) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 214), pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:26095350 | a(CHEBI:D-ribose) increases p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) |
| pubmed:26095350 | a(CHEBI:D-ribose) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) |
| pubmed:28176663 | a(CHEBI:D-ribose) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) |
| pubmed:26095350 | a(CHEBI:D-ribose) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:28176663 | a(CHEBI:D-ribose) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:26095350 | a(CHEBI:D-ribose) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) |
| pubmed:28176663 | a(CHEBI:D-ribose) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) |
| pubmed:26095350 | a(CHEBI:D-ribose) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:26095350 | a(CHEBI:D-ribose) increases p(MGI:Camk2b, pmod(go:0006468 ! "protein phosphorylation", Thr, 286), pmod(go:0006468 ! "protein phosphorylation", Thr, 287)) |
| pubmed:26095350 | a(CHEBI:D-ribose) decreases p(MGI:Camk2b, pmod(go:0006468 ! "protein phosphorylation", Thr, 305), pmod(go:0006468 ! "protein phosphorylation", Thr, 306)) |
| pubmed:19517062 | a(CHEBI:D-ribose) increases p(HGNC:MAPT, pmod(CONSO:glycation)) |
| pubmed:28176663 | a(CHEBI:D-ribose) increases a(CONSO:"advanced glycation end product") |
| pubmed:26095350 | p(MGI:Camk2b, pmod(go:0006468 ! "protein phosphorylation", Thr, 286), pmod(go:0006468 ! "protein phosphorylation", Thr, 287)) increases act(p(MGI:Camk2b)) |
| pubmed:26095350 | p(MGI:Camk2b, pmod(go:0006468 ! "protein phosphorylation", Thr, 305), pmod(go:0006468 ! "protein phosphorylation", Thr, 306)) decreases act(p(MGI:Camk2b)) |
| pubmed:22798221 | a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:22798221 | a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 198)) |
| pubmed:22798221 | a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:22798221 | a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:22798221 | a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:22798221 | a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:22798221 | a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:22798221 | a(CHEBI:methylglyoxal) increases a(CHEBI:"advanced glycation end-product") |
| pubmed:22798221 | a(CHEBI:methylglyoxal) increases p(HGNC:AGER) |
| pubmed:22798221 | a(CHEBI:methylglyoxal) increases act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) |
| pubmed:22798221 | a(CHEBI:methylglyoxal) increases act(p(MGI:Mapk14), ma(go:0016301 ! "kinase activity")) |
| pubmed:19251756 | a(CHEBI:methylglyoxal) negativeCorrelation act(p(INTERPRO:"Triosephosphate isomerase")) |
| pubmed:17082178 | a(CHEBI:methylglyoxal) increases a(GO:"neurofibrillary tangle") |
| pubmed:17082178 | a(CHEBI:methylglyoxal) increases complex(p(HGNC:MAPT), p(HGNC:MAPT)) |
| pubmed:17082178 | a(CHEBI:methylglyoxal) increases a(CONSO:"Tau oligomers") |
| pubmed:22798221 | act(p(MGI:Mapk14), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:22798221 | act(p(MGI:Mapk14), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 198)) |
| pubmed:22798221 | act(p(MGI:Mapk14), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:22798221 | act(p(MGI:Mapk14), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:22798221 | act(p(MGI:Mapk14), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:22798221 | act(p(MGI:Mapk14), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:22798221 | act(p(MGI:Mapk14), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:22798221 | act(p(MGI:Mapk14), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) |
| pubmed:19251756 | act(p(INTERPRO:"Triosephosphate isomerase")) increases rxn(reactants(a(CHEBI:"D-glyceraldehyde 3-phosphate"), a(CHEBI:"dihydroxyacetone phosphate")), products(a(CHEBI:ATP))) |
| pubmed:19251756 | p(INTERPRO:"Triosephosphate isomerase") partOf bp(GO:"canonical glycolysis") |
| pubmed:19251756 | act(p(INTERPRO:"Triosephosphate isomerase")) negativeCorrelation path(CONSO:Neurodegeneration) |
| pubmed:19251756 | act(p(INTERPRO:"Triosephosphate isomerase")) negativeCorrelation a(CHEBI:methylglyoxal) |
| pubmed:19251756 | bp(GO:"canonical glycolysis") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19251756 | bp(GO:"response to nitrosative stress") increases p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation", Tyr, 164)) |
| pubmed:19251756 | bp(GO:"response to nitrosative stress") increases p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation", Tyr, 208)) |
| pubmed:21210655 | bp(GO:"response to nitrosative stress") increases p(HGNC:MAPT, pmod(CONSO:formylation, Lys)) |
| pubmed:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation", Tyr, 164)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation", Tyr, 164)) decreases act(p(INTERPRO:"Triosephosphate isomerase")) |
| pubmed:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation", Tyr, 164)) decreases act(p(INTERPRO:"Triosephosphate isomerase")) |
| pubmed:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation", Tyr, 164)) increases a(CHEBI:methylglyoxal) |
| pubmed:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation", Tyr, 208)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation", Tyr, 208)) decreases act(p(INTERPRO:"Triosephosphate isomerase")) |
| pubmed:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation", Tyr, 208)) decreases act(p(INTERPRO:"Triosephosphate isomerase")) |
| pubmed:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation", Tyr, 208)) increases a(CHEBI:methylglyoxal) |
| pubmed:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation")) association p(HGNC:MAPT) |
| pubmed:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation")) partOf complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation"))) |
| pubmed:19251756 | complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation"))) positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:19251756 | complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation"))) partOf a(GO:"neurofibrillary tangle") |
| pubmed:18494933 | complex(p(HGNC:AGER), p(HGNC:S100B)) increases p(FPLX:JNK, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:17082178 | a(CHEBI:glyoxal) increases complex(p(HGNC:MAPT), p(HGNC:MAPT)) |
| pubmed:17082178 | a(CHEBI:glyoxal) increases a(CONSO:"Tau oligomers") |
| pubmed:17082178 | a(CHEBI:glyoxal) causesNoChange a(GO:"neurofibrillary tangle") |
| pubmed:17082178 | a(CHEBI:malonaldehyde) increases complex(p(HGNC:MAPT), p(HGNC:MAPT)) |
| pubmed:17082178 | a(CHEBI:malonaldehyde) increases a(CONSO:"Tau oligomers") |
| pubmed:17082178 | a(CHEBI:malonaldehyde) causesNoChange a(GO:"neurofibrillary tangle") |
| pubmed:16630055 | path(MESH:Fasting) decreases p(MGI:Mapt, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:16630055 | path(MESH:Fasting) increases p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) |
| pubmed:12578227 | p(HGNC:TGM1) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pubmed:12578227 | p(HGNC:TGM1) isA p(ECCODE:2.3.2.13) |
| pubmed:12578227 | p(CONSO:"TGM2 Isoform 3 (349 aa)") isA r(HGNC:TGM2) |
| pubmed:12578227 | p(HGNC:TGM2) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pubmed:12578227 | p(HGNC:TGM2) isA p(ECCODE:2.3.2.13) |
| pubmed:10537045 | p(HGNC:TGM2) positiveCorrelation p(HGNC:MAPT) |
| pubmed:10537045 | p(HGNC:TGM2) partOf complex(p(HGNC:MAPT), p(HGNC:TGM2)) |
| pubmed:10537045 | act(p(HGNC:TGM2)) association p(CONSO:"microtubule-binding region") |
| pubmed:11089576 | act(p(ECCODE:2.3.2.13)) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pubmed:11089576 | act(p(ECCODE:2.3.2.13)) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pubmed:11738469 | act(p(ECCODE:2.3.2.13)) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pubmed:8985134 | act(p(ECCODE:2.3.2.13)) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pubmed:11738469 | act(p(ECCODE:2.3.2.13)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:8985134 | act(p(ECCODE:2.3.2.13)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:9099822 | act(p(HGNCGENEFAMILY:Transglutaminases)) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pubmed:10537045 | complex(p(HGNC:MAPT), p(HGNC:TGM2)) positiveCorrelation a(CHEBI:"calcium(2+)") |
| pubmed:10537045 | a(CONSO:maitotoxin) increases a(CHEBI:"calcium(2+)") |
| pubmed:10537045 | a(CONSO:maitotoxin) increases act(p(HGNC:TGM2)) |
| pubmed:22057784 | p(HGNC:MAPT, pmod(go:0017014 ! "protein nitrosylation", Tyr, 29)) positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pubmed:17768677 | p(RGD:Mapt, pmod(CONSO:nitration, Tyr, 507)) partOf a(MESH:Brain) |
| pubmed:16816118 | a(CHEBI:linsidomine) increases a(CHEBI:peroxynitrite) |
| pubmed:16816118 | a(CHEBI:linsidomine) decreases act(p(CONSO:"20 S Proteasome")) |
| pubmed:16816118 | p(RGD:Mapt, pmod(CONSO:hyperphosphorylation)) increases a(CONSO:"Tau aggregates") |
| pubmed:16816118 | p(RGD:Mapt, pmod(CONSO:nitration)) increases a(CONSO:"Tau aggregates") |
| pubmed:16816118 | a(CHEBI:"uric acid") decreases p(RGD:Mapt, pmod(CONSO:hyperphosphorylation)) |
| pubmed:16816118 | a(CHEBI:"uric acid") decreases p(RGD:Mapt, pmod(CONSO:nitration)) |
| pubmed:16816118 | a(CHEBI:"uric acid") decreases act(a(CHEBI:peroxynitrite)) |
| pubmed:16566606 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 29)) positiveCorrelation a(GO:microtubule) |
| pubmed:16566606 | a(CONSO:"3-3 dityrosine cross-linking") positiveCorrelation a(CONSO:"paired helical filaments") |
| pubmed:27796283 | bp(GO:"dendritic spine development") positiveCorrelation a(MESH:"Dendritic Spines") |
| pubmed:27796283 | p(HGNC:TIAM1, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(HGNC:RAC1)) |
| pubmed:27796283 | p(CONSO:"Kalirin 7", pmod(go:0006468 ! "protein phosphorylation", Thr, 95)) increases act(p(CONSO:"Kalirin 7")) |
| pubmed:27796283 | act(p(CONSO:"Kalirin 7")) increases act(p(HGNC:RAC1)) |
| pubmed:27796283 | p(HGNC:CAMK1) increases p(HGNC:ARHGEF7, pmod(go:0006468 ! "protein phosphorylation", Ser, 516)) |
| pubmed:27796283 | p(HGNC:ARHGEF7, pmod(go:0006468 ! "protein phosphorylation", Ser, 516)) increases act(p(HGNC:ARHGEF7)) |
| pubmed:27796283 | act(p(HGNC:ARHGEF7)) increases act(p(HGNC:RAC1)) |
| pubmed:27796283 | complex(GO:"AMPA glutamate receptor complex") decreases act(p(HGNC:ARHGEF2)) |
| pubmed:27796283 | complex(GO:"AMPA glutamate receptor complex") association act(p(HGNC:ARHGEF2)) |
| pubmed:27796283 | complex(GO:"AMPA glutamate receptor complex") regulates act(p(HGNC:RHOA)) |
| pubmed:27796283 | act(p(HGNC:ARHGEF2)) association act(p(HGNC:RHOA)) |
| pubmed:27796283 | act(p(HGNC:ARHGEF2)) association complex(GO:"AMPA glutamate receptor complex") |
| pubmed:27796283 | act(p(HGNC:ARHGEF2)) regulates a(MESH:"Dendritic Spines") |
| pubmed:27796283 | act(p(HGNC:ARHGEF2)) regulates a(MESH:"Dendritic Spines") |
| pubmed:27796283 | act(p(HGNC:CAMKV)) decreases complex(p(HGNC:ARHGEF2), p(HGNC:RHOA)) |
| pubmed:27796283 | act(p(HGNC:CAMKV)) decreases act(p(HGNC:RHOA)) |
| pubmed:27796283 | p(HGNC:CAMKV) positiveCorrelation a(MESH:"Dendritic Spines") |
| pubmed:27796283 | act(p(HGNC:CAMKV)) regulates a(MESH:"Dendritic Spines") |
| pubmed:27796283 | p(HGNC:CAMKV) regulates bp(GO:"neuron-neuron synaptic transmission") |
| pubmed:27796283 | p(HGNC:CAMKV) association bp(MESH:"Long-Term Potentiation") |
| pubmed:27796283 | complex(p(HGNC:ARHGEF2), p(HGNC:RHOA)) positiveCorrelation act(p(HGNC:RHOA)) |
| pubmed:27796283 | p(HGNC:CAMKV, pmod(go:0006468 ! "protein phosphorylation", Thr, 345)) decreases act(p(HGNC:CAMKV)) |
| pubmed:29121589 | complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) regulates p(HGNC:NFE2L2, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:29121589 | complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) regulates deg(p(HGNC:NFE2L2)) |
| pubmed:29121589 | complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation"))) increases p(HGNC:NFE2L2, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:29121589 | complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation"))) increases deg(p(HGNC:NFE2L2)) |
| pubmed:26400044 | p(MGI:Dpysl2, pmod(go:0006468 ! "protein phosphorylation")) partOf complex(p(CONSO:"Tau aggregates"), p(MGI:Dpysl2, pmod(go:0006468 ! "protein phosphorylation")), p(MGI:Wasf1, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:26400044 | p(MGI:Dpysl2, pmod(go:0006468 ! "protein phosphorylation")) partOf complex(p(MGI:Dpysl2, pmod(go:0006468 ! "protein phosphorylation")), p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)), p(MGI:Wasf1, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:24401760 | path(CONSO:Astrogliosis) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29121589 | r(MGI:Il1b) biomarkerFor bp(GO:"inflammatory response") |
| pubmed:29121589 | r(MGI:Nos2) biomarkerFor bp(GO:"inflammatory response") |
| pubmed:27807169 | p(RGD:Cdk5r2) directlyIncreases act(p(RGD:Cdk5)) |
| pubmed:27807169 | p(RGD:Cdk5r2) positiveCorrelation a(GO:"dendritic spine") |
| pubmed:27807169 | p(RGD:Cdk5r2) positiveCorrelation a(GO:axon) |
| pubmed:27807169 | p(RGD:Cdk5r2) positiveCorrelation bp(GO:"synapse assembly") |
| pubmed:7514173 | a(CHEBI:"glycerol 2-phosphate") decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:7514173 | a(CHEBI:"diethyl pyrocarbonate") decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:7514173 | a(CHEBI:"pyridoxal 5'-phosphate") decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:7514173 | a(CHEBI:Phenylglyoxal) decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:7514173 | a(CHEBI:"poly(lysine) polymer") decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:7514173 | a(CHEBI:"sodium chloride") decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:7514173 | a(CHEBI:"sodium fluoride") decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:7514173 | a(CHEBI:"manganese(II) chloride") decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:7514173 | a(CHEBI:"calcium dichloride") decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:9089387 | act(p(FPLX:PDH, pmod(go:0006468 ! "protein phosphorylation"))) negativeCorrelation p(FPLX:PDH, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:9089387 | p(FPLX:PDH, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation act(p(FPLX:PDH, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:9089387 | p(FPLX:PDH, pmod(go:0006468 ! "protein phosphorylation")) decreases rxn(reactants(a(CHEBI:pyruvate)), products(a(CHEBI:acetyl-CoA))) |
| pubmed:9089387 | p(FPLX:PDH) partOf bp(GO:"canonical glycolysis") |
| pubmed:22102280 | a(CONSO:tideglusib) decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:22102280 | a(CHEBI:hypothemycin) decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:22102280 | a(CHEBI:alsterpaullone) decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:10998059 | a(CHEBI:alsterpaullone) decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:10998059 | a(CHEBI:alsterpaullone) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:10998059 | a(CHEBI:alsterpaullone) decreases act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) |
| pubmed:10998059 | a(CHEBI:alsterpaullone) decreases act(p(MGI:Cdk5r1)) |
| pubmed:10998059 | a(CHEBI:alsterpaullone) decreases p(MGI:Ppp1r1b, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:11013232 | a(CONSO:indirubin) decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:10998059 | act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) increases p(MGI:Ppp1r1b, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:24808823 | p(MGI:Cdk5) negativeCorrelation path(MESH:"Spatial Learning") |
| pubmed:24808823 | act(p(MGI:Cdk5)) positiveCorrelation p(MGI:Ttbk1) |
| pubmed:27087442 | p(MGI:Cdk5) decreases p(MGI:Cdk5r1) |
| pubmed:27087442 | p(MGI:Cdk5) decreases act(p(CONSO:RAC1b)) |
| pubmed:27087442 | p(MGI:Cdk5) decreases path(MESH:Cognition) |
| pubmed:27087442 | p(MGI:Cdk5) increases bp(GO:"neuron death") |
| pubmed:14642273 | act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 175)) |
| pubmed:14642273 | act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 176)) |
| pubmed:14642273 | act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 178)) |
| pubmed:14642273 | act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 195)) |
| pubmed:14642273 | act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 198)) |
| pubmed:14642273 | act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:14642273 | act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:14642273 | act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:14642273 | act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 217)) |
| pubmed:14642273 | act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 220)) |
| pubmed:14642273 | act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 235)) |
| pubmed:14642273 | act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 239)) |
| pubmed:14642273 | act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:14642273 | act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 400)) |
| pubmed:14642273 | act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 403)) |
| pubmed:8702879 | p(HGNC:SYN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 551)) negativeCorrelation act(p(HGNC:SYN1)) |
| pubmed:8702879 | act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 551)) |
| pubmed:8702879 | act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 62)) |
| pubmed:8702879 | act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 67)) |
| pubmed:8702879 | act(p(HGNC:SYN1)) increases bp(GO:"actin filament bundle assembly") |
| pubmed:8702879 | p(HGNC:SYN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 62)) negativeCorrelation act(p(HGNC:SYN1)) |
| pubmed:8702879 | p(HGNC:SYN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 67)) negativeCorrelation act(p(HGNC:SYN1)) |
| pubmed:26400044 | p(MGI:Wasf1, pmod(go:0006468 ! "protein phosphorylation")) partOf complex(p(CONSO:"Tau aggregates"), p(MGI:Dpysl2, pmod(go:0006468 ! "protein phosphorylation")), p(MGI:Wasf1, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:26400044 | p(MGI:Wasf1, pmod(go:0006468 ! "protein phosphorylation")) partOf complex(p(MGI:Dpysl2, pmod(go:0006468 ! "protein phosphorylation")), p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)), p(MGI:Wasf1, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:26400044 | complex(p(MGI:Dpysl2, pmod(go:0006468 ! "protein phosphorylation")), p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")), p(MGI:Wasf1, pmod(go:0006468 ! "protein phosphorylation"))) association path(MESH:"Plaque, Amyloid") |
| pubmed:8726973 | a(CONSO:isopentanyladenine) decreases act(p(HGNC:CDK5)) |
| pubmed:8726973 | a(CONSO:olomoucine) decreases act(p(HGNC:CDK5)) |
| pubmed:18239272 | p(HGNC:CSNK1D) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25673844 | p(HGNC:CSNK1D) isA p(FPLX:CSNK1) |
| pubmed:23088643 | p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 198)) |
| pubmed:23088643 | p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:23088643 | p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:23088643 | p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 197)) |
| pubmed:23687953 | act(p(HGNC:TTBK1), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 197)) |
| pubmed:23088643 | p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:23088643 | p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:23088643 | p(HGNC:TTBK1) association a(CONSO:pretangles) |
| pubmed:23088643 | p(HGNC:TTBK1) association a(CONSO:"Tau fibrils") |
| pubmed:20096481 | p(HGNC:TTBK1) increases act(p(HGNC:CDK5)) |
| pubmed:20096481 | p(HGNC:TTBK1) increases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:25673844 | p(HGNC:TTBK1) isA p(CONSO:"CK1 superfamily") |
| pubmed:25673844 | p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 42)) |
| pubmed:25673844 | p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 45)) |
| pubmed:25673844 | p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 47)) |
| pubmed:25673844 | p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 80)) |
| pubmed:25673844 | p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 81)) |
| pubmed:25673844 | p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Thr, 84)) |
| pubmed:25473830 | p(HGNC:TTBK1) directlyIncreases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25473830 | p(HGNC:TTBK1) increases tloc(p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation")), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) |
| pubmed:20096481 | g(DBSNP:rs2651206) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:21548880 | g(DBSNP:rs2651206) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:20096481 | g(DBSNP:rs2651206) association g(HGNC:TTBK1) |
| pubmed:21548880 | g(DBSNP:rs2651206) isA g(HGNC:TTBK1) |
| pubmed:20096481 | g(DBSNP:rs10807287) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:20096481 | g(DBSNP:rs10807287) association g(HGNC:TTBK1) |
| pubmed:20096481 | g(DBSNP:rs7764257) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:20096481 | g(DBSNP:rs7764257) association g(HGNC:TTBK1) |
| pubmed:20096481 | g(HGNC:TTBK1) association g(DBSNP:rs2651206) |
| pubmed:20096481 | g(HGNC:TTBK1) association g(DBSNP:rs10807287) |
| pubmed:20096481 | g(HGNC:TTBK1) association g(DBSNP:rs7764257) |
| pubmed:2820993 | act(p(FPLX:CSNK2)) increases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:21548880 | p(HGNC:TTBK2, var("p.Tyr448*")) positiveCorrelation path(CONSO:"Spinocerebellar Ataxia 11") |
| pubmed:21548880 | p(HGNC:TTBK2, var("p.Tyr448*")) increases p(HGNC:TTBK2) |
| pubmed:21548880 | p(HGNC:TTBK2, var("p.Tyr448*")) decreases act(p(HGNC:TTBK2), ma(go:0016301 ! "kinase activity")) |
| pubmed:21548880 | path(CONSO:"Spinocerebellar Ataxia 11") positiveCorrelation p(HGNC:TTBK2, var("p.Tyr448*")) |
| pubmed:21548880 | path(CONSO:"Spinocerebellar Ataxia 11") positiveCorrelation p(HGNC:TTBK2, var("p.Asp449*")) |
| pubmed:21548880 | path(CONSO:"Spinocerebellar Ataxia 11") positiveCorrelation p(HGNC:TTBK2, var("p.Glu450*")) |
| pubmed:21548880 | p(HGNC:TTBK2, var("p.Asp449*")) positiveCorrelation path(CONSO:"Spinocerebellar Ataxia 11") |
| pubmed:21548880 | p(HGNC:TTBK2, var("p.Asp449*")) increases p(HGNC:TTBK2) |
| pubmed:21548880 | p(HGNC:TTBK2, var("p.Asp449*")) decreases act(p(HGNC:TTBK2), ma(go:0016301 ! "kinase activity")) |
| pubmed:21548880 | p(HGNC:TTBK2, var("p.Glu450*")) positiveCorrelation path(CONSO:"Spinocerebellar Ataxia 11") |
| pubmed:21548880 | p(HGNC:TTBK2, var("p.Glu450*")) increases p(HGNC:TTBK2) |
| pubmed:21548880 | p(HGNC:TTBK2, var("p.Glu450*")) decreases act(p(HGNC:TTBK2), ma(go:0016301 ! "kinase activity")) |
| pubmed:19118186 | p(MGI:Ttbk1) increases p(MGI:Cdk5r1) |
| pubmed:19118186 | p(MGI:Ttbk1) positiveCorrelation act(p(ECCODE:3.4.22.52)) |
| pubmed:19118186 | p(MGI:Ttbk1) negativeCorrelation p(MGI:Grin2b) |
| pubmed:19118186 | p(MGI:Ttbk1) negativeCorrelation p(MGI:Grin2d) |
| pubmed:19118186 | p(MGI:Ttbk1) negativeCorrelation p(MGI:Capn1) |
| pubmed:24808823 | p(MGI:Ttbk1) negativeCorrelation path(MESH:"Spatial Learning") |
| pubmed:24808823 | p(MGI:Ttbk1) increases a(CONSO:pretangles) |
| pubmed:24808823 | p(MGI:Ttbk1) increases deg(a(MESH:"Motor Neurons")) |
| pubmed:24808823 | p(MGI:Ttbk1) increases bp(GO:"neuroinflammatory response") |
| pubmed:24808823 | p(MGI:Ttbk1) positiveCorrelation act(p(MGI:Cdk5)) |
| pubmed:19118186 | act(p(ECCODE:3.4.22.52)) positiveCorrelation p(MGI:Ttbk1) |
| pubmed:19118186 | p(MGI:Grin2b) negativeCorrelation p(MGI:Ttbk1) |
| pubmed:24808823 | tloc(p(MGI:Grin2b), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) positiveCorrelation path(MESH:"Spatial Learning") |
| pubmed:19118186 | p(MGI:Grin2d) negativeCorrelation p(MGI:Ttbk1) |
| pubmed:19118186 | complex(p(MGI:Cdk5), p(MGI:Cdk5r1)) negativeCorrelation complex(a(GO:"filamentous actin"), p(MGI:Cdk5r1)) |
| pubmed:19118186 | complex(p(MGI:Cdk5), p(MGI:Cdk5r1)) negativeCorrelation complex(GO:"filamentous actin") |
| pubmed:19118186 | complex(a(GO:"filamentous actin"), p(MGI:Cdk5r1)) negativeCorrelation complex(p(MGI:Cdk5), p(MGI:Cdk5r1)) |
| pubmed:25673844 | p(HGNC:VRK1) isA p(CONSO:"CK1 superfamily") |
| pubmed:25673844 | p(HGNC:VRK2) isA p(CONSO:"CK1 superfamily") |
| pubmed:25673844 | p(HGNC:VRK3) isA p(CONSO:"CK1 superfamily") |
| pubmed:25673844 | p(HGNC:CSNK1A1L) isA p(FPLX:CSNK1) |
| pubmed:25673844 | p(HGNC:CSNK1E) isA p(FPLX:CSNK1) |
| pubmed:25673844 | p(HGNC:CSNK1G1) isA p(FPLX:CSNK1) |
| pubmed:25673844 | p(HGNC:CSNK1G2) isA p(FPLX:CSNK1) |
| pubmed:25673844 | p(HGNC:CSNK1G3) isA p(FPLX:CSNK1) |
| pubmed:25673844 | p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Thr, 84)) increases complex(p(HGNC:SV2A), p(HGNC:SYT1)) |
| pubmed:27607061 | act(p(HGNC:GRIK2)) positiveCorrelation tloc(p(HGNC:GRIK2), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) |
| pubmed:27607061 | tloc(p(HGNC:GRIK2), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) positiveCorrelation act(p(HGNC:GRIK2)) |
| pubmed:27607061 | tloc(p(HGNC:GRIK2), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) negativeCorrelation act(p(HGNC:RAB5A)) |
| pubmed:27607061 | tloc(p(HGNC:GRIK2), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) negativeCorrelation path(CONSO:Excitotoxicity) |
| pubmed:26323690 | complex(p(HGNC:MAPRE1), p(HGNC:TTBK2)) increases p(HGNC:KIF2A, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:26323690 | p(HGNC:KIF2A, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation bp(GO:"microtubule depolymerization") |
| pubmed:26323690 | complex(p(HGNC:MAPRE3), p(HGNC:TTBK2)) increases p(HGNC:KIF2A, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:22814243 | act(p(HGNC:SLC5A1)) positiveCorrelation bp(GO:"glucose transmembrane transport") |
| pubmed:22814243 | bp(GO:"glucose transmembrane transport") positiveCorrelation act(p(HGNC:SLC5A1)) |
| pubmed:25297623 | p(HGNC:CEP164) association p(HGNC:TTBK2) |
| pubmed:25297623 | p(HGNC:CEP164) increases p(HGNC:TTBK2, loc(GO:centriole)) |
| pubmed:25297623 | p(HGNC:CEP164) partOf complex(p(HGNC:CEP164), p(HGNC:TTBK2)) |
| pubmed:25297623 | p(HGNC:CEP164) partOf complex(p(HGNC:CEP164), p(HGNC:DVL3)) |
| pubmed:25297623 | complex(p(HGNC:CEP164), p(HGNC:TTBK2)) increases act(p(HGNC:TTBK2)) |
| pubmed:25297623 | p(HGNC:CEP164, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation complex(p(HGNC:CEP164), p(HGNC:DVL3)) |
| pubmed:25297623 | complex(p(HGNC:CEP164), p(HGNC:DVL3)) negativeCorrelation p(HGNC:CEP164, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25297623 | p(HGNC:DVL3) partOf complex(p(HGNC:CEP164), p(HGNC:DVL3)) |
| pubmed:25297623 | p(HGNC:DVL3) regulates bp(GO:"cytosolic ciliogenesis") |
| pubmed:11943212 | p(HGNC:MAPK11) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) |
| pubmed:11943212 | p(HGNC:MAPK11) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:11943212 | p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) |
| pubmed:11943212 | p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:11943212 | p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:11943212 | p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 396)) |
| pubmed:11943212 | p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:11943212 | p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:11943212 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 396)) partOf p(CONSO:"Tau epitope, AD2") |
| pubmed:26751493 | complex(p(CONSO:"projection domain"), p(HGNC:LCK)) association bp(GO:"cell-cell signaling") |
| pubmed:26751493 | complex(p(CONSO:"projection domain"), p(HGNC:FGR)) association bp(GO:"cell-cell signaling") |
| pubmed:26751493 | complex(p(CONSO:"projection domain"), p(HGNC:SRC)) association bp(GO:"cell-cell signaling") |
| pubmed:26751493 | complex(p(CONSO:"projection domain"), p(HGNC:GRB2)) association bp(GO:"cell-cell signaling") |
| pubmed:26751493 | complex(p(CONSO:"projection domain"), p(FPLX:PLC)) association bp(GO:"cell-cell signaling") |
| pubmed:26751493 | complex(a(CHEBI:phosphatidylinositol), p(CONSO:"projection domain")) association bp(GO:"cell-cell signaling") |
| pubmed:26751493 | complex(a(CHEBI:"phosphatidylinositol bisphosphate"), p(CONSO:"projection domain")) association bp(GO:"cell-cell signaling") |
| pubmed:26751493 | complex(p(CONSO:"projection domain"), p(HGNC:PIN1)) association bp(GO:"cell-cell signaling") |
| pubmed:26751493 | p(INTERPRO:"Syntaxin, N-terminal domain") negativeCorrelation a(GO:"neurofibrillary tangle") |
| pubmed:11943212 | p(HGNC:MARK4, pmod(go:0006468 ! "protein phosphorylation")) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:22692785 | p(HGNC:MARK4) negativeCorrelation p(CONSO:PrPSc) |
| pubmed:22156579 | p(HGNC:MARK4) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:23666762 | p(HGNC:MARK4) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:27708431 | p(HGNC:MARK4) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:22156579 | p(HGNC:MARK4) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) |
| pubmed:23666762 | p(HGNC:MARK4) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22156579 | p(HGNC:MARK4) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:22156579 | p(HGNC:MARK4) negativeCorrelation act(p(RGD:Dlg4)) |
| pubmed:22156579 | p(HGNC:MARK4) negativeCorrelation p(RGD:Gria1) |
| pubmed:22156579 | p(HGNC:MARK4) negativeCorrelation a(GO:"dendritic spine") |
| pubmed:22156579 | p(HGNC:MARK4) negativeCorrelation a(GO:synapse) |
| pubmed:11943212 | complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)), p(HGNC:MARK4, pmod(go:0006468 ! "protein phosphorylation"))) association path(CONSO:"granulovacuolar degeneration") |
| pubmed:22692785 | p(CONSO:PrP106-126) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:16973293 | p(CONSO:"MARK4 isoform 2 (688 aa)") positiveCorrelation bp(GO:"neuron development") |
| pubmed:16973293 | p(CONSO:"MARK4 isoform 2 (688 aa)") isA p(HGNC:MARK4) |
| pubmed:23666762 | complex(p(HGNC:MAPT), p(HGNC:MARK1)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:23666762 | complex(p(HGNC:MAPT), p(HGNC:MARK2)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:23666762 | complex(p(HGNC:MAPT), p(HGNC:MARK3)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:23666762 | complex(p(HGNC:MAPT), p(HGNC:MARK4)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:23666762 | complex(p(HGNC:MAPT), p(HGNC:MARK4)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:23666762 | p(CONSO:"CagA peptide") decreases act(p(HGNC:MARK4), ma(go:0016301 ! "kinase activity")) |
| pubmed:23666762 | p(CONSO:"CagA peptide") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:27798139 | act(p(MGI:Dapk1)) increases a(GO:synapse) |
| pubmed:27798139 | act(p(MGI:Dapk1)) decreases path(MESH:"Spatial Learning") |
| pubmed:27798139 | act(p(MGI:Dapk1)) decreases bp(GO:memory) |
| pubmed:25995053 | act(p(MGI:Dapk1), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:27094130 | p(HGNC:DAPK1) increases tloc(p(HGNC:APP, frag("672_713")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27094130 | act(p(HGNC:DAPK1), ma(go:0016301 ! "kinase activity")) positiveCorrelation tloc(p(HGNC:APP, frag("672_713")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:27094130 | act(p(HGNC:DAPK1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) |
| pubmed:27094130 | act(p(HGNC:DAPK1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) |
| pubmed:27068745 | act(p(HGNC:DAPK1)) increases bp(GO:"neuron apoptotic process") |
| pubmed:27795443 | act(p(HGNC:DAPK1)) negativeCorrelation act(p(HGNC:JUND)) |
| pubmed:27795443 | act(p(HGNC:DAPK1)) increases bp(GO:"apoptotic process") |
| pubmed:24853415 | p(HGNC:DAPK1) increases p(HGNC:PIN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 71)) |
| pubmed:24853415 | p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:23948915 | p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:21311567 | act(p(HGNC:DAPK1), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:24853415 | p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:23948915 | p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:24853415 | p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:23948915 | p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:24853415 | p(HGNC:DAPK1) positiveCorrelation p(HGNC:MAPT) |
| pubmed:21311567 | p(HGNC:DAPK1) directlyIncreases act(p(HGNC:MARK1)) |
| pubmed:21311567 | p(HGNC:DAPK1) directlyIncreases act(p(HGNC:MARK2)) |
| pubmed:21311567 | p(HGNC:DAPK1) decreases bp(GO:"microtubule polymerization") |
| pubmed:27094130 | p(HGNC:DAPK1, frag("637_1423")) partOf p(HGNC:DAPK1) |
| pubmed:27094130 | p(HGNC:DAPK1, frag("848_1423")) partOf p(HGNC:DAPK1) |
| pubmed:27094130 | p(HGNC:DAPK1, frag("1271_1423")) equivalentTo p(INTERPRO:"Death domain") |
| pubmed:27094130 | p(INTERPRO:"Death domain") equivalentTo p(HGNC:DAPK1, frag("1271_1423")) |
| pubmed:27094130 | p(INTERPRO:"Death domain") partOf p(HGNC:DAPK1) |
| pubmed:27068745 | p(HGNC:UNC5B) increases act(p(HGNC:DAPK1)) |
| pubmed:27068745 | p(HGNC:UNC5B) positiveCorrelation act(p(FPLX:PPP2), ma(go:0016791 ! "phosphatase activity")) |
| pubmed:27068745 | act(p(HGNC:DAPK1, pmod(go:0006468 ! "protein phosphorylation"))) decreases act(p(HGNC:DAPK1)) |
| pubmed:27068745 | p(HGNC:UNC5C) positiveCorrelation bp(GO:"neuron apoptotic process") |
| pubmed:27068745 | p(HGNC:UNC5C, var("p.Thr835Met")) increases bp(GO:"neuron apoptotic process") |
| pubmed:27068745 | p(HGNC:UNC5C, var("p.Thr835Met")) positiveCorrelation act(p(HGNC:PRKD1)) |
| pubmed:27068745 | p(HGNC:CALML5) decreases bp(GO:"neuron apoptotic process") |
| pubmed:27068745 | act(p(HGNC:PRKD1)) positiveCorrelation p(HGNC:UNC5C, var("p.Thr835Met")) |
| pubmed:27068745 | act(p(HGNC:PRKD1)) positiveCorrelation act(p(HGNC:MAP3K5)) |
| pubmed:27068745 | p(ECCODE:1.6.3.1) positiveCorrelation act(p(FPLX:JNK)) |
| pubmed:27795443 | act(p(HGNC:JUND)) decreases bp(GO:"apoptotic process") |
| pubmed:27795443 | act(p(HGNC:JUND)) negativeCorrelation act(p(HGNC:DAPK1)) |
| pubmed:27795443 | act(p(HGNC:CSK), ma(go:0016301 ! "kinase activity")) increases p(HGNC:DAPK1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27795443 | act(p(HGNC:CSK), ma(go:0016301 ! "kinase activity")) decreases act(p(HGNC:DAPK1)) |
| pubmed:27133022 | p(CONSO:"DAPK, basic loop (BL) motif") partOf p(HGNC:DAPK2) |
| pubmed:27133022 | p(CONSO:"DAPK, basic loop (BL) motif") positiveCorrelation act(p(HGNC:DAPK2)) |
| pubmed:27133022 | p(CONSO:"DAPK, basic loop (BL) motif") positiveCorrelation complex(p(FPLX:CALM), p(HGNC:DAPK2)) |
| pubmed:27133022 | p(CONSO:"DAPK, basic loop (BL) motif") positiveCorrelation complex(a(CHEBI:"calcium(2+)"), p(HGNC:DAPK2)) |
| pubmed:27133022 | act(p(HGNC:DAPK2)) positiveCorrelation p(CONSO:"DAPK, basic loop (BL) motif") |
| pubmed:27133022 | complex(p(FPLX:CALM), p(HGNC:DAPK2)) positiveCorrelation p(CONSO:"DAPK, basic loop (BL) motif") |
| pubmed:27133022 | complex(a(CHEBI:"calcium(2+)"), p(HGNC:DAPK2)) positiveCorrelation p(CONSO:"DAPK, basic loop (BL) motif") |
| pubmed:25995053 | complex(p(MGI:Dapk1), p(MGI:Mapt)) decreases a(GO:"dendritic spine") |
| pubmed:25995053 | complex(p(MGI:Dapk1), p(MGI:Mapt)) increases bp(GO:"neuron apoptotic process") |
| pubmed:24853415 | p(HGNC:PIN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 71)) decreases act(p(HGNC:PIN1)) |
| pubmed:22926167 | p(HGNC:PIN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 71)) decreases p(HGNC:PIN1) |
| pubmed:24853415 | p(HGNC:PIN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 71)) positiveCorrelation p(HGNC:MAPT) |
| pubmed:28137862 | p(MGI:Dcaf1) association p(MGI:Dyrk1a) |
| pubmed:28137862 | p(MGI:Dcaf1) partOf complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) |
| pubmed:28137862 | p(MGI:Dcaf1) association p(MGI:Hap1) |
| pubmed:28137862 | p(MGI:Dyrk1a) association p(MGI:Dcaf1) |
| pubmed:28137862 | p(MGI:Dyrk1a) partOf complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) |
| pubmed:28137862 | p(MGI:Dyrk1a) negativeCorrelation p(MGI:Hap1) |
| pubmed:29221819 | p(MGI:Dyrk1a) negativeCorrelation a(CONSO:"granular layer of cerebellar cortex") |
| pubmed:29221819 | p(MGI:Dyrk1a) negativeCorrelation a(CONSO:"molecular layer of cerebellar cortex") |
| pubmed:29221819 | p(MGI:Dyrk1a) negativeCorrelation a(CONSO:"Purkinje cell layer of cerebellar cortex") |
| pubmed:29221819 | p(MGI:Dyrk1a) negativeCorrelation bp(GO:"dendrite arborization") |
| pubmed:29221819 | p(MGI:Dyrk1a) positiveCorrelation bp(GO:"cellular senescence") |
| pubmed:29221819 | p(MGI:Dyrk1a) positiveCorrelation path(HP:Neurodegeneration) |
| pubmed:29221819 | p(MGI:Dyrk1a) positiveCorrelation p(MGI:App) |
| pubmed:29221819 | p(MGI:Dyrk1a) positiveCorrelation a(CHEBI:amyloid-beta) |
| pubmed:29221819 | p(MGI:Dyrk1a) positiveCorrelation p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:29221819 | p(MGI:Dyrk1a) positiveCorrelation p(MGI:Mapt) |
| pubmed:28540658 | p(MGI:Dyrk1a) decreases a(CHEBI:serotonin) |
| pubmed:28540658 | p(MGI:Dyrk1a) decreases a(CHEBI:dopamine) |
| pubmed:28540658 | p(MGI:Dyrk1a) decreases a(CHEBI:adrenaline) |
| pubmed:28775333 | p(MGI:Dyrk1a) positiveCorrelation p(CONSO:"3R tau") |
| pubmed:28775333 | p(MGI:Dyrk1a) negativeCorrelation p(CONSO:"4R tau") |
| pubmed:28775333 | p(MGI:Dyrk1a) positiveCorrelation path(MESH:Anxiety) |
| pubmed:28775333 | p(MGI:Dyrk1a) negativeCorrelation bp(GO:memory) |
| pubmed:28137862 | complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) negativeCorrelation p(MGI:Hap1) |
| pubmed:28137862 | p(MGI:Hap1) association p(MGI:Dcaf1) |
| pubmed:28137862 | p(MGI:Hap1) negativeCorrelation p(MGI:Dyrk1a) |
| pubmed:28137862 | p(MGI:Hap1) negativeCorrelation complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) |
| pubmed:29221819 | a(CONSO:"granular layer of cerebellar cortex") negativeCorrelation p(MGI:Dyrk1a) |
| pubmed:29221819 | a(CONSO:"molecular layer of cerebellar cortex") negativeCorrelation p(MGI:Dyrk1a) |
| pubmed:29221819 | bp(GO:"dendrite arborization") negativeCorrelation p(MGI:Dyrk1a) |
| pubmed:28884684 | a(CONSO:ID-8) decreases act(p(HGNC:DYRK1B), ma(go:0016301 ! "kinase activity")) |
| pubmed:28884684 | a(CONSO:ID-8) decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:28884684 | a(CONSO:ID-8) decreases act(p(HGNC:DYRK1A), ma(go:0016301 ! "kinase activity")) |
| pubmed:28884684 | a(CONSO:ID-8) decreases bp(GO:"neuron differentiation") |
| pubmed:28250274 | a(CHEBI:harmine) decreases p(HGNC:DYRK1A) |
| pubmed:28250274 | a(CHEBI:harmine) increases p(HGNC:MME) |
| pubmed:29077046 | a(CHEBI:harmine) increases complex(a(CHEBI:harmine), g(HGNC:DYRK1A)) |
| pubmed:28775333 | p(MGI:Mef2d) increases r(MGI:Dyrk1a) |
| pubmed:28775333 | p(MGI:Mef2d) increases act(p(MGI:Dyrk1a), ma(go:0016301 ! "kinase activity")) |
| pubmed:28632203 | composite(a(CHEBI:homocysteine), p(HGNC:BDNF), p(HGNC:DYRK1A)) biomarkerFor path(MESH:"Alzheimer Disease") |
| pubmed:28167836 | p(HGNC:DYRK1A, var("p.Arg205del")) decreases act(p(HGNC:DYRK1A)) |
| pubmed:28167836 | p(HGNC:DYRK1A, var("p.Glu239del")) decreases act(p(HGNC:DYRK1A)) |
| pubmed:18070606 | p(RGD:Syk) increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) |
| pubmed:26501932 | a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") partOf a(GO:"synaptic vesicle") |
| pubmed:26501932 | a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") partOf a(CONSO:"GVD bodies") |
| pubmed:26501932 | a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") partOf a(CONSO:pretangles) |
| pubmed:25331948 | a(PUBCHEM:10200390) directlyDecreases act(p(HGNC:SYK)) |
| pubmed:28176663 | a(CONSO:"Braak_Stage V") negativeCorrelation act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) |
| pubmed:28176663 | a(CONSO:"advanced glycation end product") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) |
| pubmed:28176663 | a(CONSO:"advanced glycation end product") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) |
| pubmed:28176663 | a(CONSO:"advanced glycation end product") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:25987199 | act(a(CONSO:"advanced glycation end product")) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:26118667 | p(HGNC:CDK5R1, frag("99_307")) equivalentTo p(CONSO:"CDK5R1 p25") |
| pubmed:26118667 | path(CONSO:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:26118667 | path(CONSO:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:26118667 | path(CONSO:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:26118667 | path(CONSO:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:26118667 | path(CONSO:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:26118667 | path(CONSO:"Chronic cerebral hypoperfusion") increases p(CONSO:"CDK5R1 p25") |
| pubmed:26118667 | path(CONSO:"Chronic cerebral hypoperfusion") increases p(FPLX:NFkappaB) |
| pubmed:26118667 | m(MIRBASE:rno-mir-195) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:26118667 | m(MIRBASE:rno-mir-195) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:26118667 | m(MIRBASE:rno-mir-195) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:26118667 | m(MIRBASE:rno-mir-195) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:26118667 | m(MIRBASE:rno-mir-195) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:26118667 | m(MIRBASE:rno-mir-195) decreases act(p(CONSO:"CDK5R1 p25")) |
| pubmed:26118667 | m(MIRBASE:rno-mir-195) increases complex(g(RGD:Cdk5r1), m(MIRBASE:rno-mir-195)) |
| pubmed:26118667 | m(MIRBASE:rno-mir-195) decreases p(RGD:App) |
| pubmed:26118667 | m(MIRBASE:rno-mir-195) decreases p(RGD:Bace1) |
| pubmed:26118667 | m(MIRBASE:rno-mir-195) decreases a(CHEBI:amyloid-beta) |
| pubmed:26118667 | m(MIRBASE:rno-mir-195) decreases p(RGD:Cdk5r1) |
| pubmed:26118667 | complex(g(RGD:Cdk5r1), m(MIRBASE:rno-mir-195)) decreases r(RGD:Cdk5r1) |
| pubmed:26118667 | complex(g(MIRBASE:rno-mir-195), p(FPLX:NFkappaB)) decreases m(MIRBASE:rno-mir-195) |
| pubmed:26118667 | rxn(reactants(p(RGD:Cdk5r1)), products(p(CONSO:"CDK5R1 p25"))) positiveCorrelation act(p(FPLX:CAPN)) |
| pubmed:25987199 | act(p(MGI:Glp1r)) regulates act(p(MGI:Ppargc1a)) |
| pubmed:25987199 | act(p(MGI:Glp1r)) decreases act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) |
| pubmed:25987199 | act(p(MGI:Glp1r)) decreases p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) |
| pubmed:25125464 | a(PUBCHEM:9821250) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:25125464 | a(PUBCHEM:9821250) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 204)) |
| pubmed:25125464 | a(PUBCHEM:9821250) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:25125464 | a(PUBCHEM:9821250) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:25125464 | a(PUBCHEM:9821250) causesNoChange p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:25125464 | a(PUBCHEM:9821250) causesNoChange p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:25125464 | a(PUBCHEM:9821250) decreases p(FPLX:JNK, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:25125464 | a(GO:"neuron spine") positiveCorrelation p(MGI:Fyn) |
| pubmed:22833681 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 214)) partOf p(CONSO:"Tau epitope, AT100") |
| pubmed:23294633 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 214)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pubmed:22833681 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 212)) partOf p(CONSO:"Tau epitope, AT100") |
| pubmed:23294633 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 212)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pubmed:22833681 | path(CONSO:"Long-Term Depression") positiveCorrelation act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) |
| pubmed:22833681 | a(CONSO:"Thiamet G") directlyDecreases act(p(ECCODE:3.2.1.169)) |
| pubmed:22833681 | act(p(ECCODE:3.2.1.169)) increases p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) |
| pubmed:23294633 | p(MGI:Gsk3b, pmod(go:0006468 ! "protein phosphorylation", Tyr, 279)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pubmed:23294633 | p(MGI:Gsk3b, pmod(go:0006468 ! "protein phosphorylation", Tyr, 279)) increases act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) |
| pubmed:23294633 | p(MGI:Gsk3b, pmod(go:0006468 ! "protein phosphorylation", Tyr, 216)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pubmed:23294633 | p(MGI:Gsk3b, pmod(go:0006468 ! "protein phosphorylation", Tyr, 216)) increases act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) |
| pubmed:22002427 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Glu391*")) |
| pubmed:24251416 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 352)) partOf p(CONSO:"tubulin-binding repeat 4") |
| pubmed:22156579 | act(p(RGD:Dlg4)) negativeCorrelation p(HGNC:MARK4) |
| pubmed:22156579 | p(RGD:Gria1) negativeCorrelation p(HGNC:MARK4) |
| pubmed:23722080 | a(CHEBI:"sodium azide") directlyDecreases a(GO:mitochondrion) |
| pubmed:23722080 | a(CHEBI:"sodium azide") positiveCorrelation composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) |
| pubmed:23722080 | composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) positiveCorrelation a(CHEBI:"sodium azide") |
| pubmed:23722080 | composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) positiveCorrelation a(CHEBI:"hydrogen peroxide") |
| pubmed:23722080 | composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases a(CHEBI:"glutamate(1-)") |
| pubmed:23722080 | composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(RGD:Gsk3b, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23722080 | composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:23722080 | composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(RGD:Bace1) |
| pubmed:23722080 | composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(CONSO:"CDK5R1 p25") |
| pubmed:23722080 | composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) decreases bp(GO:"cellular metabolic process") |
| pubmed:29421605 | p(RGD:Gsk3b, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation bp(GO:aging) |
| pubmed:23722080 | composite(a(CHEBI:"L-ascorbic acid"), a(CHEBI:Trolox), a(CHEBI:glutathione)) decreases p(RGD:Mapt, pmod(CONSO:hyperphosphorylation)) |
| pubmed:23722080 | composite(a(CHEBI:"L-ascorbic acid"), a(CHEBI:Trolox), a(CHEBI:glutathione)) increases bp(GO:"cellular metabolic process") |
| pubmed:22952452 | p(HGNC:TRAK1) increases bp(GO:"axonal transport of mitochondrion") |
| pubmed:22952452 | p(HGNC:TRAK1) decreases path(CONSO:Neurodegeneration) |
| pubmed:22952452 | p(HGNC:TRAK1) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:22952452 | p(HGNC:TRAK1) decreases act(p(HGNC:MARK1)) |
| pubmed:23001711 | p(HGNC:CHEK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) |
| pubmed:22072628 | p(CONSO:"proline-rich region 2", pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation bp(MESH:"Protein Conformation, alpha-Helical") |
| pubmed:22072628 | p(HGNC:MAPT, frag("235_324")) association bp(MESH:"Protein Conformation, alpha-Helical") |
| pubmed:8226987 | p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 261)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) |
| pubmed:24401760 | p(HGNC:ITPKB) positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pubmed:24401760 | p(HGNC:ITPKB) positiveCorrelation a(CONSO:"dystrophic neurite") |
| pubmed:24401760 | p(MGI:Itpkb) increases bp(GO:"apoptotic process") |
| pubmed:24401760 | p(MGI:Itpkb) increases act(p(MGI:Bace1)) |
| pubmed:24401760 | p(MGI:Itpkb) increases act(p(MGI:Map2k1)) |
| pubmed:24401760 | p(MGI:Itpkb) increases act(p(MGI:Map2k2)) |
| pubmed:24401760 | p(MGI:Itpkb) increases path(CONSO:Astrogliosis) |
| pubmed:24401760 | p(MGI:Itpkb) increases p(HGNC:APP, frag("672_711")) |
| pubmed:24401760 | p(MGI:Itpkb) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:24401760 | a(PUBCHEM:9549284) directlyDecreases p(MGI:Map2k1) |
| pubmed:24401760 | a(PUBCHEM:9549284) directlyDecreases p(MGI:Map2k2) |
| pubmed:24401760 | a(PUBCHEM:9549284) decreases a(CHEBI:amyloid-beta) |
| pubmed:23737518 | a(PUBCHEM:54581340) directlyDecreases act(p(RGD:Cdk5)) |
| pubmed:23737518 | a(PUBCHEM:54581340) decreases p(CONSO:"Tau epitope, PHF1") |
| pubmed:23737518 | a(PUBCHEM:54581340) decreases act(p(CONSO:"CDK5R1 p25")) |
| pubmed:23737518 | a(PUBCHEM:54581340) directlyDecreases act(p(RGD:Gsk3b)) |
| pubmed:23737518 | a(PUBCHEM:54581340) isA a(CONSO:diaminothiazole) |
| pubmed:23737518 | a(CONSO:diaminothiazole) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:23737518 | a(CONSO:diaminothiazole) increases bp(GO:memory) |
| pubmed:23737518 | a(CONSO:LDN-193665) isA a(CONSO:diaminothiazole) |
| pubmed:23737518 | a(CONSO:LDN-193665) directlyDecreases act(p(RGD:Cdk5)) |
| pubmed:23737518 | a(CONSO:LDN-193665) directlyDecreases act(p(RGD:Gsk3b)) |
| pubmed:23737518 | a(CONSO:LDN-213843) isA a(CONSO:diaminothiazole) |
| pubmed:23737518 | a(CONSO:LDN-213843) directlyDecreases act(p(RGD:Cdk5)) |
| pubmed:23737518 | a(CONSO:LDN-213843) directlyDecreases act(p(RGD:Gsk3b)) |
| pubmed:7667312 | p(HGNC:MAPT, var("p.Cys291Ala")) decreases a(CONSO:"paired helical filaments") |
| pubmed:7667312 | a(CONSO:"Thioflavin S") positiveCorrelation a(CONSO:"paired helical filaments") |
| pubmed:25672970 | a(CONSO:C-30-27) directlyDecreases act(p(HGNC:KAT2B)) |
| pubmed:25672970 | a(CONSO:C-30-27) decreases p(FPLX:NFkappaB, pmod(go:0006473 ! "protein acetylation", Lys, 122)) |
| pubmed:25672970 | a(CONSO:C-30-27) decreases bp(GO:"neuroinflammatory response") |
| pubmed:25672970 | a(CONSO:C-30-27) increases path(MESH:Cognition) |
| pubmed:25672970 | a(CONSO:C-30-27) increases bp(GO:locomotion) |
| pubmed:25672970 | a(CONSO:C-30-27) increases bp(GO:"synaptic transmission, cholinergic") |
| pubmed:27917100 | a(CONSO:ST7612AA1) directlyDecreases act(p(FPLX:HDAC)) |
| pubmed:26890116 | a(CONSO:"Biphenyl-4-yl-acrylohydroxamoc acids") directlyDecreases act(p(FPLX:HDAC)) |
| pubmed:18558669 | a(CONSO:Trithiocarbonates) directlyDecreases act(p(HGNC:HDAC6)) |
| pubmed:29540553 | p(MGI:Sirt3) decreases p(HGNC:MAPT) |
| pubmed:29540553 | p(MGI:Sirt3) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:29540553 | p(MGI:Sirt3) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:27550730 | a(PUBCHEM:136299192) directlyDecreases act(p(MGI:Pde5a)) |
| pubmed:27550730 | a(PUBCHEM:136299192) directlyDecreases act(p(FPLX:HDAC)) |
| pubmed:27550730 | a(PUBCHEM:136299192) increases bp(GO:"long-term synaptic potentiation") |
| pubmed:27550730 | a(PUBCHEM:136299192) decreases a(CHEBI:amyloid-beta) |
| pubmed:27550730 | a(PUBCHEM:136299192) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:27550730 | a(PUBCHEM:136299192) decreases act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) |
| pubmed:27550730 | act(p(HGNC:PDE5A)) negativeCorrelation act(p(FPLX:CREB)) |
| pubmed:29559585 | p(MGI:Gapdh, pmod(go:0017014 ! "protein nitrosylation")) increases p(MGI:Ep300, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:29559585 | p(MGI:Gapdh, pmod(go:0017014 ! "protein nitrosylation")) increases act(p(MGI:Ep300)) |
| pubmed:29559585 | p(MGI:Gapdh, pmod(go:0017014 ! "protein nitrosylation")) increases p(MGI:Sirt1, pmod(go:0017014 ! "protein nitrosylation")) |
| pubmed:29559585 | p(MGI:Gapdh, pmod(go:0017014 ! "protein nitrosylation")) decreases act(p(MGI:Sirt1)) |
| pubmed:29559585 | p(HGNC:GAPDH, pmod(go:0017014 ! "protein nitrosylation")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:29559585 | a(PUBCHEM:6419718) decreases p(MGI:Gapdh, pmod(go:0017014 ! "protein nitrosylation")) |
| pubmed:29559585 | a(PUBCHEM:6419718) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) |
| pubmed:29559585 | a(PUBCHEM:6419718) increases bp(GO:memory) |
| pubmed:29559585 | a(PUBCHEM:6419718) increases bp(GO:locomotion) |
| pubmed:28855586 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 163), pmod(go:0006473 ! "protein acetylation", Lys, 280), pmod(go:0006473 ! "protein acetylation", Lys, 281), pmod(go:0006473 ! "protein acetylation", Lys, 369)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28855586 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 163), pmod(go:0006473 ! "protein acetylation", Lys, 280), pmod(go:0006473 ! "protein acetylation", Lys, 281), pmod(go:0006473 ! "protein acetylation", Lys, 369)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:28855586 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 163), pmod(go:0006473 ! "protein acetylation", Lys, 280), pmod(go:0006473 ! "protein acetylation", Lys, 281), pmod(go:0006473 ! "protein acetylation", Lys, 369)) negativeCorrelation act(a(CHEBI:amyloid-beta)) |
| pubmed:19401603 | complex(a(MESH:Microtubules), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:28287136 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280), pmod(go:0006473 ! "protein acetylation", Lys, 281)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) |
| pubmed:28287136 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280), pmod(go:0006473 ! "protein acetylation", Lys, 281)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) |
| pubmed:28287136 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280), pmod(go:0006473 ! "protein acetylation", Lys, 281)) increases a(CONSO:"Tau aggregates") |
| pubmed:28002468 | p(HGNC:MAP4, frag("992_999")) equivalentTo p(CONSO:"VQIINK motif") |
| pubmed:28002468 | p(HGNC:MAP4, frag("1023_1030")) equivalentTo p(CONSO:"VQIINK motif") |
| pubmed:28002468 | p(HGNC:MAP2, frag("332_339")) equivalentTo p(CONSO:"VQIVYK motif") |
| pubmed:28002468 | bp(CONSO:"cystein-dependent auto-acetylation") increases p(HGNC:MAP2, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:27041503 | p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 281)) decreases bp(MESH:"Long-Term Potentiation") |
| pubmed:27041503 | p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 281)) decreases p(MGI:Wwc1) |
| pubmed:27041503 | p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 281)) decreases bp(GO:"actin cytoskeleton reorganization") |
| pubmed:27041503 | p(MGI:Wwc1) increases bp(MESH:"Long-Term Potentiation") |
| pubmed:26390242 | a(CHEBI:salsalate) directlyDecreases act(p(HGNC:EP300)) |
| pubmed:26390242 | a(CHEBI:salsalate) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) |
| pubmed:26390242 | a(CHEBI:salsalate) decreases p(HGNC:MAPT) |
| pubmed:26390242 | a(CHEBI:salsalate) increases bp(GO:memory) |
| pubmed:26390242 | a(CHEBI:salsalate) decreases path(CONSO:Neurodegeneration) |
| pubmed:26390242 | a(CHEBI:salicylate) directlyDecreases act(p(HGNC:EP300)) |
| pubmed:26390242 | a(CHEBI:salicylate) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) |
| pubmed:26390242 | a(CHEBI:salicylate) decreases p(HGNC:MAPT) |
| pubmed:26390242 | a(CHEBI:salicylate) increases bp(GO:memory) |
| pubmed:26390242 | a(CHEBI:salicylate) decreases path(CONSO:Neurodegeneration) |
| pubmed:26192747 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 225)) isA p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:26192747 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 317)) isA p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:26192747 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 317)) partOf p(CONSO:"microtubule-binding region") |
| pubmed:26192747 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 331)) isA p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:26192747 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 331)) partOf p(CONSO:"microtubule-binding region") |
| pubmed:26192747 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 343)) isA p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:26192747 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 343)) partOf p(CONSO:"microtubule-binding region") |
| pubmed:26192747 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 347)) isA p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:26192747 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 347)) partOf p(CONSO:"microtubule-binding region") |
| pubmed:26192747 | p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 385)) isA p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:24686445 | path(CONSO:"peripheral nervous system injury") increases act(p(FPLX:ERK)) |
| pubmed:20869593 | a(CHEBI:C646) directlyDecreases act(p(HGNC:EP300)) |
| pubmed:20869593 | a(CHEBI:C646) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) |
| pubmed:29226865 | p(HGNC:SRSF2, pmod(go:0006473 ! "protein acetylation", Lys, 52)) positiveCorrelation act(p(HGNC:SRSF2)) |
| pubmed:28771976 | a(PUBCHEM:56650312) directlyDecreases act(p(HGNC:HDAC3)) |
| pubmed:28771976 | a(CONSO:RGFP966) association bp(GO:memory) |
| pubmed:29844403 | p(INTERPRO:"Heat shock protein Hsp90 family", pmod(go:0006473 ! "protein acetylation")) decreases complex(p(HGNC:HDAC6), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pubmed:29844403 | p(INTERPRO:"Heat shock protein Hsp90 family", pmod(go:0006473 ! "protein acetylation")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"), pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:19732809 | g(HGNC:OGA, var("?")) decreases act(complex(GO:"proteasome complex")) |
| pubmed:19732809 | g(HGNC:OGA, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:26041011 | a(CONSO:"USP14 Aptamer") decreases act(p(HGNC:USP14)) |
| pubmed:27325702 | p(CONSO:"APP, ACR") association p(HGNC:STUB1) |
| pubmed:27325702 | p(CONSO:"APP, ACR") association p(CONSO:"CRL4 complex") |
| pubmed:27325702 | p(CONSO:"APP, ACR") increases p(HGNC:SCAMP1, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:27325702 | p(CONSO:"APP, ACR") increases p(HGNC:SV2A, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:27325702 | p(CONSO:"APP, ACR") increases p(HGNC:SV2B, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:27325702 | p(CONSO:"APP, ACR") increases p(HGNC:VAMP2, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:27325702 | p(CONSO:"APP, ACR") increases p(HGNC:ATP6V0A1, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:27325702 | p(CONSO:"APP, ACR") increases p(HGNC:SLC17A7, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:27325702 | p(CONSO:"APP, ACR") increases p(HGNC:SYT1, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:27325702 | p(CONSO:"APP, ACR") increases p(HGNC:SYT2, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:27325702 | p(CONSO:"APP, ACR") increases p(HGNC:RAB14, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:27325702 | p(CONSO:"APP, ACR") increases p(HGNC:SNAP25, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:27325702 | p(CONSO:"APP, ACR") increases p(HGNC:SYN2, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:27325702 | p(CONSO:"APP, ACR") increases p(HGNC:SYN1, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:27325702 | p(CONSO:"APP, ACR") increases p(HGNC:RAB3A, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:27325702 | p(CONSO:"APP, ACR") increases p(HGNC:APOE, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:27325702 | p(CONSO:"APP, ACR") increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:27325702 | p(CONSO:"APP, ACR") regulates complex(GO:"ubiquitin ligase complex") |
| pubmed:27325702 | p(CONSO:"CRL4 complex") association p(CONSO:"APP, ACR") |
| pubmed:27325702 | p(CONSO:"CRL4 complex") equivalentTo complex(p(HGNC:CRBN), p(HGNC:CUL4A), p(HGNC:CUL4B), p(HGNC:DDB1)) |
| pubmed:27325702 | p(CONSO:"CRL4 complex") isA complex(GO:"ubiquitin ligase complex") |
| pubmed:27325702 | complex(p(HGNC:CRBN), p(HGNC:CUL4A), p(HGNC:CUL4B), p(HGNC:DDB1)) equivalentTo p(CONSO:"CRL4 complex") |
| pubmed:25378699 | p(HGNC:MAPT, pmod(go:0016925 ! "protein sumoylation", Lys, 340)) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:25378699 | p(HGNC:MAPT, pmod(go:0016925 ! "protein sumoylation", Lys, 340)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:25378699 | p(HGNC:MAPT, pmod(go:0016925 ! "protein sumoylation", Lys, 340)) decreases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:8391280 | p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination", Lys, 257)) positiveCorrelation a(CONSO:"paired helical filaments") |
| pubmed:27260838 | p(CONSO:"Tau antibody, TNT1") association p(CONSO:"phosphatase-activating domain") |
| pubmed:27260838 | p(CONSO:"Tau antibody, TNT2") association p(CONSO:"phosphatase-activating domain") |
| pubmed:27601475 | a(CONSO:8-nitro-cGMP) decreases a(CONSO:"Tau oligomers") |
| pubmed:27601475 | a(CONSO:8-nitro-cGMP) positiveCorrelation a(CHEBI:"nitric oxide") |
| pubmed:27601475 | act(p(ECCODE:1.14.13.39)) directlyIncreases a(CHEBI:"nitric oxide") |
| pubmed:27373205 | p(CONSO:"Tau dimers") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) |
| pubmed:11606569 | g(DBSNP:rs63750688) equivalentTo p(HGNC:MAPT, var("p.Lys280del")) |
| pubmed:19765634 | g(DBSNP:rs761059) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:19765634 | g(DBSNP:rs8052688) positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pubmed:19765634 | g(DBSNP:rs8063) positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pubmed:21843595 | p(MGI:Sumo3) negativeCorrelation bp(GO:learning) |
| pubmed:21843595 | p(MGI:Sumo3) negativeCorrelation bp(GO:memory) |
| pubmed:19782030 | act(p(RGD:Stat1)) increases r(RGD:Irf1) |
| pubmed:19782030 | act(p(RGD:Stat1)) increases r(RGD:Tnf) |
| pubmed:19782030 | act(p(RGD:Stat1)) increases r(RGD:Il6) |
| pubmed:19782030 | p(RGD:Pias1) increases p(RGD:Nr1h2, pmod(go:0016925 ! "protein sumoylation")) |
| pubmed:19782030 | p(RGD:Hdac4) increases p(RGD:Nr1h3, pmod(go:0016925 ! "protein sumoylation")) |
| pubmed:19782030 | p(RGD:Nr1h2, pmod(go:0016925 ! "protein sumoylation")) increases act(p(RGD:Stat1)) |
| pubmed:19782030 | p(RGD:Nr1h3, pmod(go:0016925 ! "protein sumoylation")) increases act(p(RGD:Stat1)) |
| pubmed:19323834 | complex(p(FPLX:CEBP), p(HGNC:SUMO1)) directlyDecreases r(HGNC:NOS2) |
| pubmed:19323834 | p(FPLX:CEBP) partOf complex(p(FPLX:CEBP), p(HGNC:SUMO1)) |
| pubmed:19323834 | p(HGNC:SENP1) directlyDecreases r(HGNC:NOS2) |
| pubmed:18675254 | p(HGNC:APP, pmod(go:0016925 ! "protein sumoylation", Lys, 587)) negativeCorrelation a(CHEBI:amyloid-beta) |
| pubmed:18675254 | p(HGNC:APP, pmod(go:0016925 ! "protein sumoylation", Lys, 595)) negativeCorrelation a(CHEBI:amyloid-beta) |
| pubmed:18675254 | complex(GO:"endoplasmic reticulum") association p(HGNC:UBE2I) |
| pubmed:16464864 | a(CHEBI:colchicine) increases p(HGNC:MAPT, pmod(go:0016925 ! "protein sumoylation", Lys, 340)) |
| pubmed:12506199 | p(HGNC:SUMO3, var("p.Lys11Arg")) increases p(HGNC:APP, pmod(go:0016925 ! "protein sumoylation")) |
| pubmed:12506199 | p(HGNC:SUMO3, var("p.Lys11Arg")) increases a(CHEBI:amyloid-beta) |
| pubmed:12506199 | p(HGNC:APP, pmod(go:0016925 ! "protein sumoylation")) increases a(CHEBI:amyloid-beta) |
| pubmed:12506199 | p(HGNC:APP, pmod(CONSO:polysumoylation)) decreases a(CHEBI:amyloid-beta) |
| pubmed:29334120 | p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 403)) |
| pubmed:29334120 | p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:29334120 | p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 409)) |
| pubmed:29334120 | p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 410)) |
| pubmed:29334120 | p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 409)) increases act(p(HGNC:TARDBP)) |
| pubmed:29334120 | p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 410)) increases act(p(HGNC:TARDBP)) |
| pubmed:29228318 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2CB)) decreases deg(p(HGNC:PPP2CB)) |
| pubmed:29228318 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2CB)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2CB)) |
| pubmed:29228318 | complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2CB)) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:29228318 | complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2CB)) decreases a(CONSO:"paired helical filaments") |
| pubmed:29228318 | complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2CB)) decreases a(MESH:Axons) |
| pubmed:29228318 | complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2CB)) decreases bp(GO:"cell death") |
| pubmed:29421605 | p(RGD:Ptpn1) positiveCorrelation bp(GO:aging) |
| pubmed:29421605 | p(RGD:Irs1, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation bp(GO:aging) |
| pubmed:29421605 | p(RGD:Akt1, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation bp(GO:aging) |
| pubmed:29421605 | p(RGD:Mtor, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation bp(GO:aging) |
| pubmed:29421605 | p(RGD:Ntrk2, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation bp(GO:aging) |
| pubmed:29062069 | p(HGNC:MID1) decreases act(p(HGNC:PPP2CA)) |
| pubmed:29062069 | p(HGNC:MID1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:28422052 | a(CHEBI:"folic acid") decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) |
| pubmed:28422052 | a(CHEBI:"folic acid") increases r(MGI:Dnmt1) |
| pubmed:28422052 | a(CHEBI:"folic acid") increases p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) |
| pubmed:25143394 | p(MGI:Ppp1ca) negativeCorrelation p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) |
| pubmed:25143394 | p(MGI:Ppp1cb) negativeCorrelation p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) |
| pubmed:23134599 | a(CHEBI:"lead diacetate") decreases p(RGD:Ppp2ca) |
| pubmed:23134599 | a(CHEBI:"lead diacetate") increases p(RGD:Ppp1ca) |
| pubmed:23134599 | a(CHEBI:"lead diacetate") increases p(RGD:Ppp5c) |
| pubmed:23134599 | a(CHEBI:"lead diacetate") increases p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) |
| pubmed:21489990 | p(RGD:Egr1) increases act(p(RGD:Cdk5)) |
| pubmed:21489990 | p(RGD:Egr1) increases p(FPLX:PPP1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:21489990 | p(FPLX:PPP1, pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(FPLX:PPP1)) |
| pubmed:19623258 | act(complex(GO:"NMDA selective glutamate receptor complex")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) |
| pubmed:19623258 | act(complex(GO:"NMDA selective glutamate receptor complex")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) |
| pubmed:19623258 | act(complex(GO:"NMDA selective glutamate receptor complex")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:25001178 | p(HGNC:DUSP6) directlyDecreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:25001178 | p(HGNC:DUSP6) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:25001178 | p(HGNC:DUSP6) decreases p(FPLX:ERK) |
| pubmed:25001178 | p(HGNC:BCL2L2) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) |
| pubmed:24964035 | p(FPLX:SMAD) decreases p(HGNC:PIN1) |
| pubmed:24964035 | p(FPLX:SMAD) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pubmed:22926167 | p(HGNC:PIN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 16)) decreases p(HGNC:PIN1) |
| pubmed:22926167 | p(HGNC:PIN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 16)) decreases p(HGNC:PIN1, loc(MESH:"Cell Nucleus")) |
| pubmed:22926167 | p(HGNC:PIN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 65)) decreases p(HGNC:PIN1) |
| pubmed:22926167 | p(HGNC:PIN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 65)) causesNoChange p(HGNC:PIN1, loc(MESH:"Cell Nucleus")) |
| pubmed:22926167 | p(HGNC:PIN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 65)) decreases p(HGNC:PIN1, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:22926167 | p(HGNC:PIN1, pmod(go:0006473 ! "protein acetylation", Lys, 46)) decreases p(HGNC:PIN1) |
| pubmed:22926167 | complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)), p(HGNC:PIN1)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) |
| pubmed:22926167 | p(HGNC:PIN1, pmod(go:0016567 ! "protein ubiquitination")) increases deg(p(HGNC:PIN1)) |
| pubmed:18305152 | complex(GO:"exon-exon junction complex") increases bp(GO:"RNA splicing") |
| pubmed:27181519 | bp(GO:"RNA splicing") association p(HGNC:FUS) |
| pubmed:27181519 | bp(GO:"RNA splicing") association p(HGNC:TARDBP) |
| pubmed:18305152 | path(OMIT:0026893) isA path(EFO:"neurodegenerative disease") |
| pubmed:23384725 | path(OMIT:0026893) association p(HGNC:TARDBP) |
| pubmed:28669544 | path(OMIT:0026893) increases p(HGNC:TARDBP, pmod(CONSO:"protein aggregation"), pmod(go:0016567 ! "protein ubiquitination"), loc(MESH:"Inclusion Bodies")) |
| pubmed:28669544 | path(OMIT:0026893) negativeCorrelation a(MESH:"Frontal Lobe") |
| pubmed:28669544 | path(EFO:"neurodegenerative disease") increases path(HP:"CNS demyelination") |
| pubmed:18305152 | path(EFO:"amyotrophic lateral sclerosis") isA path(EFO:"neurodegenerative disease") |
| pubmed:18305152 | act(p(HGNC:RB1)) association p(HGNC:CDK6) |
| pubmed:18305152 | act(p(HGNC:RB1)) association p(HGNC:NAP1L1) |
| pubmed:18305152 | p(HGNC:RB1) regulates p(HGNC:NAP1L1) |
| pubmed:18305152 | act(p(HGNC:RB1)) association p(HGNC:CDK2) |
| pubmed:18305152 | act(p(HGNC:RB1)) association p(HGNC:CKS1B) |
| pubmed:18305152 | act(p(HGNC:RB1)) association p(HGNC:CCNG1) |
| pubmed:18305152 | act(p(HGNC:RB1)) association p(HGNC:PLK1) |
| pubmed:18305152 | act(p(HGNC:RB1)) association p(HGNC:CCNB1) |
| pubmed:18305152 | act(p(HGNC:RB1)) association p(HGNC:EID1) |
| pubmed:18305152 | act(p(HGNC:RB1)) association p(HGNC:TOP1) |
| pubmed:18305152 | act(p(HGNC:RB1)) association p(HGNC:POLD4) |
| pubmed:18305152 | act(p(HGNC:RB1)) association p(HGNC:RRM2) |
| pubmed:18305152 | act(p(HGNC:RB1)) association p(HGNC:RBBP4) |
| pubmed:18305152 | act(p(HGNC:RB1)) association p(HGNC:UBE2C) |
| pubmed:18305152 | act(p(HGNC:RB1)) association p(HGNC:SKP2) |
| pubmed:18305152 | act(p(HGNC:RB1)) association p(HGNC:HDAC1) |
| pubmed:18305152 | act(p(HGNC:RB1)) association p(HGNC:E2F8) |
| pubmed:18305152 | p(HGNC:RB1) regulates p(HGNC:E2F8) |
| pubmed:18305152 | p(HGNC:RB1) regulates bp(GO:"cell cycle") |
| pubmed:18305152 | p(HGNC:RB1) regulates bp(GO:"cell differentiation") |
| pubmed:18305152 | p(HGNC:RB1) regulates bp(GO:"chromosome organization") |
| pubmed:18305152 | p(HGNC:NAP1L1) association act(p(HGNC:RB1)) |
| pubmed:18305152 | p(HGNC:CKS1B) association act(p(HGNC:RB1)) |
| pubmed:18305152 | p(HGNC:CCNG1) association act(p(HGNC:RB1)) |
| pubmed:18305152 | p(HGNC:PLK1) association act(p(HGNC:RB1)) |
| pubmed:18305152 | p(HGNC:CCNB1) association act(p(HGNC:RB1)) |
| pubmed:18305152 | p(HGNC:CCNB1) regulates bp(GO:"cell cycle") |
| pubmed:18305152 | p(HGNC:EID1) association act(p(HGNC:RB1)) |
| pubmed:18305152 | p(HGNC:TOP1) association act(p(HGNC:RB1)) |
| pubmed:18305152 | p(HGNC:POLD4) association act(p(HGNC:RB1)) |
| pubmed:18305152 | p(HGNC:POLD4) regulates bp(GO:"cell cycle") |
| pubmed:18305152 | p(HGNC:RRM2) association act(p(HGNC:RB1)) |
| pubmed:18305152 | p(HGNC:RBBP4) association act(p(HGNC:RB1)) |
| pubmed:18305152 | p(HGNC:UBE2C) association act(p(HGNC:RB1)) |
| pubmed:18305152 | p(HGNC:UBE2C) regulates bp(GO:"cell cycle") |
| pubmed:18305152 | p(HGNC:SKP2) association act(p(HGNC:RB1)) |
| pubmed:18305152 | p(HGNC:SKP2) regulates bp(GO:"cell cycle") |
| pubmed:18305152 | p(HGNC:E2F8) association act(p(HGNC:RB1)) |
| pubmed:18305152 | p(HGNCGENEFAMILY:"Cyclin dependent kinases") increases p(HGNC:RB1, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:18305152 | p(HGNC:RB1, pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(HGNC:RB1)) |
| pubmed:18305152 | p(HGNC:RB1, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(MESH:"Transcription Factors")) |
| pubmed:18305152 | p(HGNC:RB1, pmod(go:0006468 ! "protein phosphorylation")) increases bp(GO:"cell cycle G1/S phase transition") |
| pubmed:18305152 | bp(GO:"cell cycle G1/S phase transition") negativeCorrelation p(HGNC:TARDBP) |
| pubmed:18305152 | composite(p(HGNC:HDAC1), p(HGNC:RB1)) increases complex(p(HGNC:HDAC1), p(HGNC:RB1)) |
| pubmed:18305152 | composite(p(HGNC:RB1), p(HGNC:RBBP4)) increases complex(p(HGNC:RB1), p(HGNC:RBBP4)) |
| pubmed:18305152 | composite(p(HGNC:EID1), p(HGNC:RB1)) increases complex(p(HGNC:EID1), p(HGNC:RB1)) |
| pubmed:18305152 | composite(p(HGNC:CDK4), p(HGNC:CDK6)) increases bp(GO:"regulation of G0 to G1 transition") |
| pubmed:18305152 | composite(p(HGNC:CDK6), p(HGNC:RB1)) increases complex(p(HGNC:CDK6), p(HGNC:RB1)) |
| pubmed:18305152 | composite(p(HGNC:CDK6), p(HGNC:RBL2)) increases complex(p(HGNC:CDK6), p(HGNC:RBL2)) |
| pubmed:18305152 | composite(p(HGNC:CDK6), p(NCBIGENE:3005)) increases complex(p(HGNC:CDK6), p(NCBIGENE:3005)) |
| pubmed:18305152 | composite(p(HGNC:BCL2), p(HGNC:CDK6)) increases complex(p(HGNC:BCL2), p(HGNC:CDK6)) |
| pubmed:18305152 | bp(GO:"G0 to G1 transition") positiveCorrelation p(HGNC:TARDBP) |
| pubmed:18305152 | bp(GO:"cell cycle G2/M phase transition") negativeCorrelation p(HGNC:TARDBP) |
| pubmed:18305152 | path(MESH:"Cell Nucleus Shape") negativeCorrelation p(HGNC:TARDBP) |
| pubmed:18305152 | bp(GO:"meiotic DNA double-strand break formation") increases p(NCBIGENE:3014, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:18305152 | p(HGNC:PARP1, frag("?")) increases bp(GO:"induction of programmed cell death") |
| pubmed:18305152 | path(NCIT:C17768) negativeCorrelation p(HGNC:TARDBP) |
| pubmed:18305152 | path(NCIT:C91663) negativeCorrelation p(HGNC:TARDBP) |
| pubmed:18305152 | path(NCIT:C91663) regulates path(NCIT:C17768) |
| pubmed:18305152 | path(NCIT:C91663) regulates bp(GO:"programmed cell death") |
| pubmed:27181519 | bp(GO:"RNA processing") association complex(GO:"ribonucleoprotein granule") |
| pubmed:23384725 | bp(NCIT:C19375) association p(HGNC:TARDBP) |
| pubmed:23384725 | composite(a(MESH:"Inclusion Bodies"), p(HGNC:TARDBP)) association path(DOID:"Alzheimer's disease") |
| pubmed:23384725 | composite(a(MESH:"Inclusion Bodies"), p(HGNC:TARDBP)) association path(DOID:"Parkinson's disease") |
| pubmed:23384725 | composite(a(MESH:"Inclusion Bodies"), p(HGNC:TARDBP)) association path(DOID:"Huntington's disease") |
| pubmed:23384725 | p(HGNC:TARDBP, frag("1_105")) association p(CONSO:"TDP-43 oligomers") |
| pubmed:23384725 | p(CONSO:"TDP-43 oligomers") association p(HGNC:TARDBP, frag("1_105")) |
| pubmed:23384725 | act(p(HGNC:TARDBP, frag("101_191")), ma(GO:"nucleic acid binding")) association p(HGNC:TARDBP, frag("101_191")) |
| pubmed:23384725 | p(HGNC:TARDBP, frag("101_191")) association act(p(HGNC:TARDBP, frag("101_191")), ma(GO:"nucleic acid binding")) |
| pubmed:23384725 | act(p(HGNC:TARDBP, frag("101_191")), ma(GO:"nucleic acid binding")) negativeCorrelation p(HGNC:TARDBP, frag("101_191"), pmod(GO:"protein oxidation", Cys, 173)) |
| pubmed:23384725 | act(p(HGNC:TARDBP, frag("101_191")), ma(GO:"nucleic acid binding")) negativeCorrelation p(HGNC:TARDBP, frag("101_191"), pmod(GO:"protein oxidation", Cys, 175)) |
| pubmed:23384725 | act(p(HGNC:TARDBP, frag("192_265")), ma(GO:"nucleic acid binding")) association p(HGNC:TARDBP, frag("192_265")) |
| pubmed:23384725 | p(HGNC:TARDBP, frag("192_265")) association act(p(HGNC:TARDBP, frag("192_265")), ma(GO:"nucleic acid binding")) |
| pubmed:23384725 | p(HGNC:TARDBP, frag("266_414")) association bp(NCIT:C18469) |
| pubmed:23384725 | bp(NCIT:C18469) association p(HGNC:TARDBP, frag("266_414")) |
| pubmed:23384725 | p(HGNC:TARDBP, pmod(GO:"protein oxidation")) decreases bp(GO:"RNA splicing") |
| pubmed:23384725 | composite(a(CHEBI:"1,4-dithiothreitol"), p(HGNC:TARDBP, frag("101_191"))) directlyDecreases p(CONSO:"TDP-43 aggregates") |
| pubmed:23384725 | composite(a(CHEBI:"hydrogen peroxide"), p(HGNC:TARDBP, frag("101_191"))) decreases p(CONSO:"TDP-43 aggregates") |
| pubmed:23384725 | a(MESH:Oxidants) causesNoChange p(CONSO:"TDP-43 aggregates") |
| pubmed:23384725 | composite(p(HGNC:TARDBP, frag("101_191")), p(HGNC:TARDBP, frag("192_265"))) directlyIncreases p(CONSO:"TDP-43 aggregates") |
| pubmed:23384725 | p(HGNC:TARDBP, frag("101_191"), pmod(GO:"protein oxidation", Cys, 173)) association p(CONSO:"TDP-43 aggregates") |
| pubmed:23384725 | p(HGNC:TARDBP, frag("101_191"), pmod(GO:"protein oxidation", Cys, 173)) negativeCorrelation act(p(HGNC:TARDBP, frag("101_191")), ma(GO:"nucleic acid binding")) |
| pubmed:23384725 | p(HGNC:TARDBP, frag("101_191"), pmod(GO:"protein oxidation", Cys, 173)) negativeCorrelation path(MESH:"Protein Conformation") |
| pubmed:23384725 | p(HGNC:TARDBP, frag("101_191"), pmod(GO:"protein oxidation", Cys, 175)) association p(CONSO:"TDP-43 aggregates") |
| pubmed:23384725 | p(HGNC:TARDBP, frag("101_191"), pmod(GO:"protein oxidation", Cys, 175)) negativeCorrelation act(p(HGNC:TARDBP, frag("101_191")), ma(GO:"nucleic acid binding")) |
| pubmed:23384725 | p(HGNC:TARDBP, frag("101_191"), pmod(GO:"protein oxidation", Cys, 175)) association path(MESH:"Protein Conformation") |
| pubmed:23384725 | composite(p(HGNC:TARDBP, frag("101_191")), p(HGNC:TARDBP, frag("101_191"))) increases p(CONSO:"TDP-43 aggregates") |
| pubmed:27181519 | path(MESH:"Motor Neuron Disease") negativeCorrelation bp(GO:autophagy) |
| pubmed:27181519 | path(MESH:"Motor Neuron Disease") negativeCorrelation act(p(HGNC:TARDBP)) |
| pubmed:30837838 | path(MESH:"Motor Neuron Disease") association p(HGNC:TARDBP) |
| pubmed:27181519 | bp(GO:"muscle atrophy") positiveCorrelation bp(GO:"motor neuron apoptotic process") |
| pubmed:27181519 | bp(GO:"muscle atrophy") positiveCorrelation path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:27181519 | act(a(MESH:"Respiratory Muscles")) decreases path(MESH:Death) |
| pubmed:27181519 | complex(GO:"cytoplasmic stress granule") isA complex(GO:"ribonucleoprotein granule") |
| pubmed:27181519 | complex(GO:"cytoplasmic stress granule") regulates a(MESH:"RNA, Messenger") |
| pubmed:27181519 | complex(GO:"cytoplasmic stress granule") negativeCorrelation bp(GO:translation) |
| pubmed:27181519 | complex(GO:"cytoplasmic stress granule") negativeCorrelation act(complex(GO:"proteasome complex")) |
| pubmed:27181519 | complex(GO:"cytoplasmic stress granule") decreases bp(MESH:"Unfolded Protein Response") |
| pubmed:27181519 | complex(GO:"cytoplasmic stress granule", loc(MESH:"Motor Neurons")) positiveCorrelation path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:27181519 | complex(GO:"cytoplasmic stress granule") association p(HGNC:FUS, loc(GO:cytosol)) |
| pubmed:27181519 | complex(GO:"cytoplasmic stress granule") association p(HGNC:TARDBP, loc(GO:cytosol)) |
| pubmed:30837838 | complex(GO:"cytoplasmic stress granule") association p(HGNC:TARDBP) |
| pubmed:27181519 | complex(GO:"cytoplasmic stress granule") association p(INTERPRO:"Prion/Doppel protein, beta-ribbon domain") |
| pubmed:27181519 | complex(GO:"cytoplasmic stress granule") positiveCorrelation g(HGNC:C9orf72) |
| pubmed:27181519 | complex(GO:"cytoplasmic stress granule", loc(GO:autophagosome)) increases bp(GO:"stress granule disassembly") |
| pubmed:27181519 | complex(GO:"cytoplasmic stress granule") association p(HGNC:G3BP1) |
| pubmed:27181519 | bp(GO:"RNA catabolic process") association complex(GO:P-body) |
| pubmed:27181519 | a(MESH:Viruses) increases complex(GO:"cytoplasmic stress granule") |
| pubmed:24561250 | a(MESH:Viruses) increases act(complex(GO:"inflammasome complex")) |
| pubmed:27181519 | complex(a(GO:"cytoplasmic stress granule"), a(MESH:"RNA, Messenger")) decreases bp(GO:translation) |
| pubmed:27181519 | p(HGNC:TIA1) increases bp(GO:"stress granule assembly") |
| pubmed:27181519 | a(CHEBI:"autophagy inhibitor") decreases deg(complex(GO:"cytoplasmic stress granule")) |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(GO:"protein complex oligomerization")) increases act(p(HGNC:TARDBP), ma(GO:"RNA binding")) |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(GO:"protein complex oligomerization")) increases p(MESH:"RNA Splicing Factors") |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(GO:"protein complex oligomerization")) increases path(MESH:"Cytotoxicity, Immunologic") |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(GO:"protein complex oligomerization")) biomarkerFor path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:28669544 | p(HGNC:TARDBP, pmod(CONSO:"protein aggregation"), loc(GO:cytosol)) directlyDecreases p(HGNC:TARDBP, loc(GO:nucleus)) |
| pubmed:28669544 | p(HGNC:TARDBP, pmod(CONSO:"protein aggregation"), loc(GO:cytosol)) directlyIncreases act(p(HGNC:TARDBP)) |
| pubmed:28669544 | p(HGNC:TARDBP, pmod(CONSO:"protein aggregation"), loc(GO:cytosol)) directlyIncreases bp(GO:"cell death") |
| pubmed:27181519 | p(MESH:"Autophagy-Related Proteins") decreases path(MESH:"TDP-43 Proteinopathies") |
| pubmed:27181519 | p(HGNC:FUS, pmod(go:0006479 ! "protein methylation")) increases p(HGNC:FUS, loc(GO:cytoplasm)) |
| pubmed:27181519 | p(HGNC:FUS, pmod(go:0006468 ! "protein phosphorylation")) increases p(HGNC:FUS, loc(GO:cytoplasm)) |
| pubmed:27181519 | p(INTERPRO:"Prion/Doppel protein, beta-ribbon domain") association complex(GO:"cytoplasmic stress granule") |
| pubmed:27181519 | p(HGNC:MATR3) association path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:30837838 | p(HGNC:MATR3) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:27181519 | p(HGNC:HNRNPA2B1) association path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:27181519 | p(HGNC:HNRNPA1) association path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:27181519 | g(HGNC:C9orf72, var("?")) association path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:27181519 | g(HGNC:C9orf72) association p(HGNC:RAB1A) |
| pubmed:27181519 | g(HGNC:C9orf72) association p(HGNC:RAB1B) |
| pubmed:27181519 | g(HGNC:C9orf72) association p(HGNC:RAB5A) |
| pubmed:27181519 | g(HGNC:C9orf72) association p(HGNC:RAB7A) |
| pubmed:27181519 | g(HGNC:C9orf72) association p(HGNC:RAB11A) |
| pubmed:27181519 | g(HGNC:C9orf72) association p(HGNC:RAB11B) |
| pubmed:27181519 | g(HGNC:C9orf72) increases act(a(GO:autophagosome)) |
| pubmed:27181519 | g(HGNC:C9orf72) positiveCorrelation act(p(HGNC:NTRK2)) |
| pubmed:27181519 | g(HGNC:C9orf72) positiveCorrelation act(p(HGNC:MAP1LC3A)) |
| pubmed:27181519 | g(HGNC:C9orf72) positiveCorrelation complex(GO:"cytoplasmic stress granule") |
| pubmed:27181519 | p(HGNC:RAB1B) association g(HGNC:C9orf72) |
| pubmed:27181519 | p(HGNC:RAB11B) association g(HGNC:C9orf72) |
| pubmed:27181519 | complex(p(HGNC:MAP1LC3A), p(HGNC:OPTN)) association bp(GO:autophagy) |
| pubmed:27181519 | complex(p(HGNC:MAP1LC3A), p(HGNC:OPTN)) increases bp(GO:mitophagy) |
| pubmed:27181519 | p(HGNC:OPTN, var("p.Glu478Gly")) association path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:27181519 | p(HGNC:OPTN, var("p.Glu478Gly")) increases complex(p(HGNC:OPTN), p(HGNC:OPTN, var("p.Glu478Gly"))) |
| pubmed:27181519 | p(HGNC:OPTN, var("p.Glu478Gly")) decreases complex(a(MESH:Ubiquitin), p(HGNC:OPTN)) |
| pubmed:27181519 | complex(p(HGNC:OPTN), p(HGNC:OPTN, var("p.Glu478Gly"))) decreases act(p(HGNC:OPTN)) |
| pubmed:27181519 | complex(p(HGNC:OPTN), p(HGNC:OPTN, var("p.Glu478Gly"))) decreases complex(a(GO:autophagosome), p(HGNC:OPTN)) |
| pubmed:27181519 | complex(p(HGNC:OPTN), p(HGNC:OPTN, var("p.Glu478Gly"))) decreases bp(GO:"autophagosome maturation") |
| pubmed:27181519 | complex(p(HGNC:OPTN), p(HGNC:OPTN, var("p.Glu478Gly"))) decreases bp(GO:autophagy) |
| pubmed:27181519 | complex(p(HGNC:OPTN), p(HGNC:OPTN, var("p.Glu478Gly"))) increases a(CONSO:"protein aggregates", loc(MESH:Cytosol)) |
| pubmed:27181519 | p(HGNC:OPTN, pmod(go:0006468 ! "protein phosphorylation")) increases bp(GO:autophagy) |
| pubmed:27181519 | complex(p(HGNC:OPTN), p(HGNC:TBK1)) association a(CONSO:"protein aggregates") |
| pubmed:27181519 | p(HGNC:OPTN, pmod(go:0006468 ! "protein phosphorylation", Ser, 177)) regulates deg(a(CONSO:"protein aggregates")) |
| pubmed:27181519 | p(HGNC:OPTN, pmod(go:0006468 ! "protein phosphorylation", Ser, 177)) regulates bp(GO:autophagy) |
| pubmed:27181519 | path(DOID:"open-angle glaucoma") association p(HGNC:OPTN, var("p.Glu50Lys")) |
| pubmed:27181519 | p(HGNC:OPTN, var("p.Glu50Lys")) association path(DOID:"open-angle glaucoma") |
| pubmed:27181519 | p(HGNC:OPTN, var("p.Glu50Lys")) increases complex(p(HGNC:OPTN), p(HGNC:TBK1)) |
| pubmed:27181519 | p(HGNC:UBQLN2, var("?")) association path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:30837838 | p(HGNC:UBQLN2, var("?")) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:UBQLN2, var("?")) decreases path(MESH:Autophagy) |
| pubmed:30837838 | p(HGNC:UBQLN2, var("?")) increases p(CONSO:"TDP-43 aggregates") |
| pubmed:27181519 | p(HGNC:UBQLN2) increases p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"proteasome complex")) |
| pubmed:27181519 | p(HGNC:UBQLN2) increases deg(p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"))) |
| pubmed:27181519 | p(HGNC:UBQLN2) increases bp(GO:"autophagosome assembly") |
| pubmed:30837838 | p(HGNC:UBQLN2) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:27181519 | complex(p(HGNC:HDAC6), p(HGNC:SQSTM1)) regulates act(p(HGNC:HDAC6), ma(GO:"protein deacetylation")) |
| pubmed:27181519 | p(HGNC:SQSTM1, var("?")) association path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:27181519 | a(CHEBI:3-methyladenine) isA a(CHEBI:"autophagy inhibitor") |
| pubmed:27181519 | a(CHEBI:3-methyladenine) decreases deg(p(HGNC:TARDBP)) |
| pubmed:30988501 | bp(MESH:"Immunity, Innate") increases path(MESH:Pathology) |
| pubmed:30988501 | bp(MESH:"Immunity, Innate") association path(MESH:Neuropsychiatry) |
| pubmed:28669544 | a(MESH:Enzymes) increases deg(p(CONSO:"protein aggregates")) |
| pubmed:28669544 | g(HGNC:TARDBP) increases p(HGNC:TARDBP) |
| pubmed:28669544 | a(MESH:"Motor Cortex") negativeCorrelation path(DOID:"amyotrophic lateral sclerosis") |
| pubmed:28669544 | composite(a(CHEBI:tamoxifen), a(MESH:Microglia)) directlyDecreases r(HGNC:TARDBP) |
| pubmed:28669544 | composite(a(CHEBI:tamoxifen), a(MESH:Microglia)) causesNoChange r(HGNC:TARDBP, loc(MESH:"Cerebral Cortex")) |
| pubmed:28669544 | composite(a(MESH:Microglia), p(HGNC:TARDBP)) increases path(MESH:"TDP-43 Proteinopathies") |
| pubmed:30837838 | p(MESH:HIV-1) association p(HGNC:TARDBP) |
| pubmed:30837838 | path(MESH:"Embryonic Development") association p(HGNC:TARDBP) |
| pubmed:30837838 | path(MESH:"Muscular Atrophy, Spinal") association p(HGNC:TARDBP) |
| pubmed:30837838 | p(HGNC:ATXN2) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:PFN1) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:UBQLN4) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:NEK1) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:CHCHD10) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:CHCHD10) decreases p(CONSO:"TDP-43 aggregates", loc(GO:cytoplasm)) |
| pubmed:30837838 | p(HGNC:CHCHD10) association a(MESH:Mitochondria) |
| pubmed:30837838 | p(HGNC:SETX) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:KIF5A) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | complex(p(HGNC:TARDBP, frag("1_102")), p(HGNC:TARDBP, frag("1_102"))) increases path(MESH:"RNA Splicing") |
| pubmed:30837838 | complex(p(HGNC:TARDBP, frag("1_102")), p(HGNC:TARDBP, frag("1_102"))) increases path(MESH:"RNA Splicing") |
| pubmed:30837838 | complex(p(HGNC:TARDBP, frag("1_102")), p(HGNC:TARDBP, frag("1_102"))) association path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30837838 | complex(p(HGNC:TARDBP, frag("1_102")), p(HGNC:TARDBP, frag("1_102"))) increases path(MESH:Solubility) |
| pubmed:30837838 | complex(p(HGNC:TARDBP, frag("1_102")), p(HGNC:TARDBP, frag("1_102"))) decreases a(MESH:"Inclusion Bodies") |
| pubmed:30837838 | path(MESH:"RNA Splicing") association p(HGNC:TARDBP, var("p.Gln133Arg")) |
| pubmed:30837838 | path(MESH:"RNA Splicing") association p(HGNC:TARDBP, var("p.Met337Val")) |
| pubmed:30837838 | p(HGNC:TARDBP, frag("82_98"), var("?")) increases p(HGNC:TARDBP, frag("1_102"), loc(MESH:Cytoplasm)) |
| pubmed:30837838 | p(HGNC:TARDBP, frag("82_98"), var("?")) increases p(CONSO:"TDP-43 aggregates") |
| pubmed:30837838 | p(HGNC:TARDBP, frag("82_98"), var("p.Ala90Val")) increases p(CONSO:"TDP-43 aggregates", loc(MESH:Cytoplasm)) |
| pubmed:30837838 | bp(GO:"mRNA processing") association p(MESH:"RNA-Binding Proteins") |
| pubmed:30837838 | path(MESH:"RNA Transport") association p(MESH:"RNA-Binding Proteins") |
| pubmed:30837838 | path(MESH:"RNA Transport") association p(HGNC:TARDBP) |
| pubmed:30837838 | p(HGNC:TARDBP, frag("104_176"), var("?")) negativeCorrelation bp(GO:"regulation of RNA binding") |
| pubmed:30837838 | p(HGNC:TARDBP, frag("104_176"), var("?")) causesNoChange path(MESH:"RNA Recognition Motif") |
| pubmed:30837838 | bp(GO:"regulation of RNA binding") negativeCorrelation p(HGNC:TARDBP, frag("104_176"), var("?")) |
| pubmed:30837838 | bp(GO:"regulation of RNA binding") negativeCorrelation p(HGNC:TARDBP, frag("192_262"), var("?")) |
| pubmed:30837838 | p(HGNC:TARDBP, frag("192_262"), var("?")) negativeCorrelation bp(GO:"regulation of RNA binding") |
| pubmed:30837838 | p(HGNC:TARDBP, frag("192_262"), var("?")) causesNoChange path(MESH:"RNA Recognition Motif") |
| pubmed:30837838 | p(HGNC:TARDBP, frag("104_176"), var("p.Pro112His")) increases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:TARDBP, frag("192_262"), var("p.Asp169Gly")) increases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:TARDBP, frag("192_262")) increases complex(p(HGNC:TARDBP, frag("1_102")), p(HGNC:TARDBP, frag("1_102"))) |
| pubmed:30837838 | composite(a(MESH:"DNA, Single-Stranded"), p(HGNC:TARDBP, frag("192_262"))) increases path(MESH:Solubility) |
| pubmed:30837838 | composite(a(MESH:"DNA, Single-Stranded"), p(HGNC:TARDBP, frag("192_262"))) decreases p(CONSO:"TDP-43 aggregates") |
| pubmed:30837838 | composite(a(MESH:"3' Untranslated Regions"), p(HGNC:TARDBP, frag("192_262"))) regulates path(MESH:Solubility) |
| pubmed:30837838 | composite(a(MESH:"3' Untranslated Regions"), p(HGNC:TARDBP, frag("192_262"))) regulates path(MESH:Homeostasis) |
| pubmed:30837838 | p(HGNC:TARDBP, frag("274_414")) association a(MESH:Cytotoxins) |
| pubmed:30837838 | p(HGNC:TARDBP, frag("274_414")) association a(MESH:"Inclusion Bodies") |
| pubmed:30837838 | p(HGNC:TARDBP, frag("274_414")) increases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30837838 | path(MESH:"Transcription, Genetic") association p(HGNC:TARDBP) |
| pubmed:30837838 | bp(GO:"primary miRNA processing") association p(HGNC:TARDBP) |
| pubmed:30837838 | p(MESH:"RNA, Long Noncoding") association p(HGNC:TARDBP) |
| pubmed:30837838 | path(MESH:"Active Transport, Cell Nucleus") association p(HGNC:TARDBP) |
| pubmed:30837838 | p(MESH:Neurons) negativeCorrelation p(HGNC:TARDBP) |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gln133Arg")) association path(MESH:"RNA Splicing") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Met337Val")) association path(MESH:"RNA Splicing") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Met337Val")) causesNoChange path(MESH:"RNA Splicing") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Met337Val")) causesNoChange path(MESH:Translations) |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Met337Val")) increases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Met337Val")) increases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Met337Val")) increases path(MESH:"Cytotoxicity, Immunologic") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Met337Val")) negativeCorrelation bp(GO:"regulation of cytoplasmic transport") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Met337Val")) increases a(MESH:"Inclusion Bodies") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Met337Val")) increases path(MESH:"Protein Stability") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Met337Val")) increases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Met337Val")) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Met337Val")) regulates bp(GO:"mRNA processing") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Met337Val")) negativeCorrelation bp(GO:translation) |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Met337Val")) increases p(CONSO:"TDP-43 aggregates") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Met337Val")) increases path(MESH:Viscosity) |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Met337Val")) decreases path(MESH:"Axonal Transport") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Met337Val")) decreases bp(GO:"mitochondrion localization") |
| pubmed:30837838 | complex(p(HGNC:TARDBP), p(MESH:RNA)) increases p(MESH:Ribonucleoproteins) |
| pubmed:30837838 | p(MESH:Ribonucleoproteins) increases path(MESH:"RNA Transport") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Ala315Thr")) causesNoChange path(MESH:"RNA Splicing") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Ala315Thr")) causesNoChange path(MESH:Translations) |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Ala315Thr")) increases p(MESH:Amyloid) |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Ala315Thr")) increases bp(GO:"neuron death") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Ala315Thr")) negativeCorrelation bp(GO:"regulation of cytoplasmic transport") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Ala315Thr")) increases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Ala315Thr")) increases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Ala315Thr")) increases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Ala315Thr")) increases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Ala315Thr")) regulates bp(GO:"mRNA processing") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Ala315Thr")) negativeCorrelation bp(GO:translation) |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Ala315Thr")) increases p(CONSO:"TDP-43 aggregates") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Ala315Thr")) increases a(CHEBI:"zinc ion") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Ala315Thr")) increases a(CHEBI:"manganese(2+)") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Ala315Thr")) increases a(CHEBI:"copper(2+)") |
| pubmed:30837838 | complex(p(HGNC:RACK1), p(HGNC:TARDBP)) increases path(MESH:"Protein Biosynthesis") |
| pubmed:30837838 | complex(p(HGNC:RACK1), p(HGNC:TARDBP)) decreases path(MESH:"Protein Biosynthesis") |
| pubmed:30837838 | p(HGNC:RACK1) increases p(HGNC:TARDBP, loc(GO:"inclusion body")) |
| pubmed:30837838 | a(CHEBI:"D-sorbitol-(13)C6") increases p(HGNC:TARDBP, var("p.Gly348Cys"), loc(GO:"cytoplasmic stress granule")) |
| pubmed:30837838 | a(CHEBI:"D-sorbitol-(13)C6") increases bp(GO:"response to osmotic stress") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gly348Cys")) increases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gly348Cys")) increases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gly348Cys")) regulates bp(GO:"mRNA processing") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gly348Cys")) negativeCorrelation bp(GO:translation) |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Arg361Ser")) decreases complex(GO:"cytoplasmic stress granule") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Arg361Ser")) increases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Arg361Ser")) increases path(MESH:"Cytotoxicity, Immunologic") |
| pubmed:30837838 | complex(p(HGNC:DROSHA), p(HGNC:TARDBP), p(MESH:MicroRNAs)) increases bp(GO:"pre-miRNA processing") |
| pubmed:30837838 | complex(p(HGNC:DICER1), p(HGNC:TARDBP)) increases bp(GO:"pre-miRNA processing") |
| pubmed:30837838 | bp(GO:"regulation of cytoplasmic transport") negativeCorrelation p(HGNC:TARDBP, var("?")) |
| pubmed:30837838 | bp(GO:"regulation of cytoplasmic transport") negativeCorrelation p(HGNC:TARDBP, var("p.Gly294Val")) |
| pubmed:30837838 | bp(GO:"regulation of cytoplasmic transport") negativeCorrelation p(HGNC:TARDBP, var("p.Ala315Thr")) |
| pubmed:30837838 | bp(GO:"regulation of cytoplasmic transport") negativeCorrelation p(HGNC:TARDBP, var("p.Met337Val")) |
| pubmed:30837838 | bp(GO:"regulation of cytoplasmic transport") negativeCorrelation p(HGNC:TARDBP, var("Ala382Thr")) |
| pubmed:30837838 | bp(GO:"regulation of cytoplasmic transport") negativeCorrelation p(HGNC:TARDBP, var("Gly376Asp")) |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Ala382Thr")) increases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Ala382Thr")) increases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Ala382Thr")) regulates bp(GO:"mRNA processing") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Ala382Thr")) negativeCorrelation bp(GO:translation) |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gln331Lys")) increases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gln331Lys")) increases path(MESH:"Cytotoxicity, Immunologic") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gln331Lys")) increases a(MESH:"Inclusion Bodies") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gln331Lys")) increases path(MESH:"Protein Stability") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gln331Lys")) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gln331Lys")) increases p(CONSO:"TDP-43 aggregates") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Asp169Gly")) increases a(MESH:"Inclusion Bodies") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Asp169Gly")) increases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Asp169Gly")) increases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Asp169Gly")) regulates bp(GO:"mRNA processing") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Asp169Gly")) negativeCorrelation bp(GO:translation) |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gly294Ala")) increases a(MESH:"Inclusion Bodies") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gly294Val")) negativeCorrelation bp(GO:"regulation of cytoplasmic transport") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gln343Arg")) increases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gln343Arg")) increases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gln343Arg")) increases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gln343Arg")) increases path(MESH:"Cytotoxicity, Immunologic") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gln343Arg")) increases a(MESH:"Inclusion Bodies") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gln343Arg")) increases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gln343Arg")) regulates bp(GO:"mRNA processing") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gln343Arg")) negativeCorrelation bp(GO:translation) |
| pubmed:30837838 | path(EFO:"familial amyotrophic lateral sclerosis") increases p(HGNC:TARDBP, var("p.Arg361Thr")) |
| pubmed:30837838 | path(EFO:"familial amyotrophic lateral sclerosis") increases p(HGNC:TARDBP, var("p.Gly295Ser")) |
| pubmed:30837838 | path(EFO:"familial amyotrophic lateral sclerosis") association p(HGNC:TARDBP, var("p.Gly295Ser"), loc(GO:mitochondrion)) |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gly295Ser"), loc(GO:mitochondrion)) association path(EFO:"familial amyotrophic lateral sclerosis") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gly295Ser"), loc(GO:mitochondrion)) increases bp(GO:"protein import into mitochondrial matrix") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Asn345Lys")) increases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Asn345Lys")) increases path(MESH:"Cytotoxicity, Immunologic") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Asn390Asp")) increases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Asn390Asp")) increases path(MESH:"Cytotoxicity, Immunologic") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Asn390Asp")) increases a(MESH:"Inclusion Bodies") |
| pubmed:30837838 | p(HGNC:TARDBP, frag("286_366"), var("?")) increases p(MESH:Amyloid) |
| pubmed:30837838 | p(MESH:Amyloid) increases p(HGNC:TARDBP, frag("274_414"), pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Ala315Glu"), loc(CONSO:"TDP-43 aggregates")) increases p(HGNC:APP, frag("1_40"), loc(CONSO:"amyloid-beta aggregates")) |
| pubmed:30837838 | p(HGNC:TARDBP, var("Ala382Thr")) negativeCorrelation bp(GO:"regulation of cytoplasmic transport") |
| pubmed:30837838 | p(HGNC:TARDBP, var("Gly376Asp")) negativeCorrelation bp(GO:"regulation of cytoplasmic transport") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gly298Ser")) increases path(MESH:"Protein Stability") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gly298Ser")) increases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gly298Ser")) increases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gly298Ser")) regulates bp(GO:"mRNA processing") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gly298Ser")) negativeCorrelation bp(GO:translation) |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gly298Ser")) increases path(MESH:Viscosity) |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gly298Ser")) decreases path(MESH:"Axonal Transport") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Asn352Ser")) increases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Asn352Ser")) increases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Asn352Ser")) regulates bp(GO:"mRNA processing") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Asn352Ser")) negativeCorrelation bp(GO:translation) |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Arg263Glu")) increases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Arg263Glu")) increases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Arg263Glu")) regulates bp(GO:"mRNA processing") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Arg263Glu")) negativeCorrelation bp(GO:translation) |
| pubmed:30837838 | path(MESH:"Nuclear Localization Signals") regulates act(p(HGNC:TARDBP)) |
| pubmed:30837838 | path(MESH:"Nuclear Export Signals") regulates act(p(HGNC:TARDBP)) |
| pubmed:30837838 | p(HGNC:TARDBP, frag("82_98")) decreases p(CONSO:"TDP-43 aggregates", loc(GO:cytoplasm)) |
| pubmed:30837838 | p(HGNC:TARDBP, frag("82_98")) increases p(HGNC:TARDBP) |
| pubmed:30837838 | path(MESH:"Chromatin Assembly and Disassembly") association p(MESH:Histones) |
| pubmed:30837838 | path(MESH:"Chromatin Assembly and Disassembly") positiveCorrelation p(HGNC:CHD1) |
| pubmed:30837838 | path(MESH:"Chromatin Assembly and Disassembly") association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:TARDBP, frag("239_250")) decreases p(CONSO:"TDP-43 aggregates", loc(GO:nucleus)) |
| pubmed:30837838 | p(HGNC:CSNK2A2) increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 379)) |
| pubmed:30837838 | p(HGNC:CSNK2A2) increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 403)) |
| pubmed:30837838 | p(HGNC:CSNK2A2) increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) |
| pubmed:30837838 | p(HGNC:CSNK2A2) increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 409)) |
| pubmed:30837838 | p(HGNC:CSNK2A2) increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 410)) |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination", Lys, 48)) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination", Lys, 63)) increases path(MESH:Autophagy) |
| pubmed:30837838 | complex(p(HGNC:TARDBP), p(HGNC:UBE2E3)) increases p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:30837838 | complex(p(HGNC:TARDBP), p(HGNC:UBE2E3)) increases p(CONSO:"TDP-43 aggregates") |
| pubmed:30837838 | complex(p(HGNC:TARDBP), p(HGNC:USP8)) increases p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:30837838 | complex(p(HGNC:TARDBP), p(HGNC:USP8)) increases p(CONSO:"TDP-43 aggregates") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Lys293Asp")) increases p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination", Lys, 48), var("?")) decreases p(CONSO:"TDP-43 aggregates") |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination", Lys, 63), var("?")) decreases p(CONSO:"TDP-43 aggregates") |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0006473 ! "protein acetylation")) increases p(HGNC:TARDBP, pmod(CONSO:hyperphosphorylation)) |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0006473 ! "protein acetylation")) negativeCorrelation act(p(HGNC:TARDBP), ma(GO:"regulation of RNA binding")) |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(go:0006473 ! "protein acetylation")) increases path(CONSO:"mitochondrial dysfunction") |
| pubmed:30837838 | a(CHEBI:"arsenite ion") increases path(MESH:"Oxidative Stress") |
| pubmed:30837838 | p(HGNC:TNKS) increases complex(a(CHEBI:"cyclic ADP-ribose"), p(HGNC:TARDBP, frag("82_98"))) |
| pubmed:30837838 | complex(a(CHEBI:"cyclic ADP-ribose"), p(HGNC:TARDBP, frag("82_98"))) decreases p(CONSO:"TDP-43 aggregates") |
| pubmed:30837838 | complex(a(CHEBI:"cyclic ADP-ribose"), p(HGNC:TARDBP)) increases complex(a(GO:"cytoplasmic stress granule"), p(HGNC:TARDBP)) |
| pubmed:30837838 | a(CHEBI:cysteine) association path(MESH:Oxidation-Reduction) |
| pubmed:30837838 | path(MESH:Oxidation-Reduction) association a(CHEBI:cysteine) |
| pubmed:30837838 | path(MESH:Oxidation-Reduction) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | bp(GO:"peptidyl-cysteine oxidation") association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | bp(GO:"peptidyl-cysteine oxidation") increases complex(p(HGNC:TARDBP), p(HGNC:TARDBP)) |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gly358Cys")) increases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Ser379Cys")) increases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gly295Cys")) increases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gly295Cys")) increases complex(p(HGNC:TARDBP, var("p.Gly295Cys")), p(HGNC:TARDBP, var("p.Gly295Cys"))) |
| pubmed:30837838 | p(HGNC:TARDBP, frag("104_176")) association p(HGNC:TARDBP, pmod(MESH:"Protein Folding")) |
| pubmed:30837838 | p(HGNC:TARDBP, pmod(MESH:"Protein Folding")) association p(HGNC:TARDBP, frag("104_176")) |
| pubmed:30837838 | p(HGNC:TARDBP, frag("247_250")) increases p(CONSO:"TDP-43 aggregates") |
| pubmed:30837838 | p(HGNC:TARDBP, frag("247_250")) association p(HGNC:IAPP) |
| pubmed:30837838 | p(HGNC:TARDBP, frag("312_316")) increases p(CONSO:"TDP-43 aggregates") |
| pubmed:30837838 | p(HGNC:TARDBP, frag("312_316")) association p(HGNC:IAPP) |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gly335Asp")) increases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Gly335Asp")) increases p(CONSO:"TDP-43 aggregates") |
| pubmed:30837838 | p(HGNC:TARDBP, frag("312_317"), var("p.Ala315Thr")) increases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:TARDBP, frag("312_317"), var("p.Ala315Glu")) increases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | bp(GO:"response to osmotic stress") increases p(HGNC:TARDBP, pmod(GO:"protein complex oligomerization")) |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Ala321Gly")) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | p(HGNC:TARDBP, var("p.Ala321Gly")) increases p(CONSO:"TDP-43 aggregates") |
| pubmed:30837838 | p(HGNC:TARDBP, frag("1_102"), pmod(go:0006468 ! "protein phosphorylation", Ser, 48)) increases p(HGNC:TARDBP, frag("1_102"), pmod(MESH:Polymerization)) |
| pubmed:30837838 | complex(p(HGNC:ATG7), p(HGNC:TARDBP)) regulates path(MESH:Autophagy) |
| pubmed:30837838 | bp(GO:"vacuole fusion") association deg(p(HGNC:TARDBP)) |
| pubmed:30837838 | bp(GO:"vacuole fusion") association path(MESH:"Cell Survival") |
| pubmed:30837838 | path(MESH:"Endoplasmic Reticulum-Associated Degradation") association deg(p(HGNC:TARDBP)) |
| pubmed:30837838 | path(MESH:"Endoplasmic Reticulum-Associated Degradation") association path(MESH:"Cell Survival") |
| pubmed:30837838 | p(HGNCGENEFAMILY:ESCRT-0) decreases p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) |
| pubmed:30837838 | bp(GO:"cytoplasm protein quality control by the ubiquitin-proteasome system") increases deg(p(HGNC:TARDBP)) |
| pubmed:30837838 | path(MESH:Endocytosis) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | path(MESH:Endocytosis) decreases p(CONSO:"TDP-43 aggregates") |
| pubmed:30837838 | path(MESH:Transportation) association bp(GO:"neuron fate commitment") |
| pubmed:30837838 | path(MESH:Transportation) association path(MESH:"Nerve Degeneration") |
| pubmed:30837838 | bp(GO:"neuron fate commitment") association path(MESH:Transportation) |
| pubmed:30837838 | bp(GO:"neuron fate commitment") association path(MESH:"Mitochondrial Size") |
| pubmed:30837838 | bp(GO:"neuron fate commitment") association a(CHEBI:"calcium(2+)") |
| pubmed:30837838 | bp(GO:"neuron fate commitment") association path(MESH:"Cell Respiration") |
| pubmed:30837838 | bp(GO:"neuron fate commitment") association bp(GO:"ATP biosynthetic process") |
| pubmed:30837838 | path(MESH:"Mitochondrial Size") association bp(GO:"neuron fate commitment") |
| pubmed:30837838 | path(MESH:"Mitochondrial Size") association path(MESH:"Nerve Degeneration") |
| pubmed:30837838 | path(MESH:"Cell Respiration") association bp(GO:"neuron fate commitment") |
| pubmed:30837838 | path(MESH:"Cell Respiration") association path(MESH:"Nerve Degeneration") |
| pubmed:30837838 | a(CHEBI:"etacrynic acid") decreases a(CHEBI:glutathione) |
| pubmed:30837838 | complex(a(CHEBI:4-hydroxynonenal), p(HGNC:TARDBP)) decreases deg(p(HGNC:TARDBP)) |
| pubmed:30837838 | complex(a(CHEBI:4-hydroxynonenal), p(HGNC:TARDBP)) increases p(HGNC:TARDBP, loc(GO:cytoplasm)) |
| pubmed:30837838 | p(HGNC:SOD1, pmod(MESH:"Protein Aggregates"), var("?")) increases p(CONSO:"TDP-43 aggregates") |
| pubmed:30837838 | p(HGNC:SOD1, pmod(MESH:"Protein Aggregates"), var("?")) negativeCorrelation p(HGNC:TARDBP, loc(GO:cytoplasm)) |
| pubmed:30837838 | complex(p(HGNC:SOD1, var("?")), p(HGNC:TARDBP, frag("274_414"))) increases a(MESH:"Toxic Actions") |
| pubmed:30837838 | complex(p(HGNC:RMDN3), p(HGNC:VAPB)) decreases path(MESH:Autophagy) |
| pubmed:30837838 | p(HGNC:SART3) decreases p(HGNC:DNM1L) |
| pubmed:30837838 | p(HGNC:SART3) decreases p(HGNC:FIS1) |
| pubmed:30837838 | bp(GO:"mitochondrion localization") increases path(MESH:"Cognitive Dysfunction") |
| pubmed:30837838 | bp(GO:"mitochondrion localization") decreases path(MESH:"Recovery of Function") |
| pubmed:30837838 | a(CHEBI:"zinc ion") increases a(MESH:"Inclusion Bodies") |
| pubmed:30837838 | a(CHEBI:"zinc ion") increases path(MESH:"Protein Aggregation, Pathological") |
| pubmed:30837838 | a(CHEBI:"lead atom") increases p(HGNC:TARDBP, loc(GO:"inclusion body")) |
| pubmed:30837838 | a(CHEBI:"lead atom") decreases act(p(HGNC:TARDBP), ma(MESH:"RNA Splicing")) |
| pubmed:30837838 | a(CHEBI:"mercury atom") increases p(HGNC:TARDBP, loc(GO:"inclusion body")) |
| pubmed:30837838 | a(CHEBI:"tin atom") increases p(HGNC:TARDBP, loc(GO:"inclusion body")) |
| pubmed:30837838 | a(PUBCHEM:6860) decreases act(p(HGNC:TARDBP), ma(MESH:"RNA Splicing")) |
| pubmed:30837838 | p(MESH:"Heat-Shock Proteins") increases p(CONSO:"TDP-43 aggregates", loc(GO:nucleus)) |
| pubmed:30837838 | p(HGNC:CHD1) increases p(MESH:"Heat-Shock Proteins") |
| pubmed:30837838 | p(HGNC:CHD1) positiveCorrelation path(MESH:"Chromatin Assembly and Disassembly") |
| pubmed:30837838 | p(HGNC:CHD2) decreases p(HGNC:TARDBP, loc(GO:cytoplasm)) |
| pubmed:30837838 | p(HGNC:SS18) regulates path(MESH:"Cell Differentiation") |
| pubmed:30837838 | p(HGNC:SS18) regulates bp(GO:"dendrite extension") |
| pubmed:30837838 | p(HGNC:SS18) regulates path(MESH:"Synaptic Transmission") |
| pubmed:30837838 | p(HGNC:TARDBP, var("Met337Val")) decreases p(CONSO:"Histone H3", pmod(go:0006468 ! "protein phosphorylation", Ser, 10), pmod(go:0006473 ! "protein acetylation", Lys, 14)) |
| pubmed:30837838 | p(HGNC:TARDBP, var("Met337Val")) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | path(MESH:Sclerosis) association p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) |
| pubmed:30837838 | path(MESH:Sclerosis) association p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) |
| pubmed:30837838 | p(CHEBI:Riluzole) decreases p(HGNCGENEFAMILY:"Glutamate metabotropic receptors") |
| pubmed:30837838 | p(CHEBI:Riluzole) regulates a(CHEBI:"D-glutamate(1-)") |
| pubmed:30837838 | p(CHEBI:Riluzole) regulates bp(GO:"chemical synaptic transmission, postsynaptic") |
| pubmed:30837838 | p(CHEBI:Riluzole) decreases p(MESH:"Voltage-Gated Sodium Channels") |
| pubmed:30837838 | a(CHEBI:mexiletine) decreases p(MESH:"Voltage-Gated Sodium Channels") |
| pubmed:30837838 | a(CHEBI:mexiletine) decreases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | a(CHEBI:edaravone) isA a(MESH:Antioxidants) |
| pubmed:30837838 | a(CHEBI:edaravone) decreases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | a(CHEBI:edaravone) isA a(MESH:"Free Radical Scavengers") |
| pubmed:30837838 | a(CHEBI:edaravone) decreases path(MESH:"Oxidative Stress") |
| pubmed:30837838 | a(CHEBI:Riluzole) decreases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pubmed:30837838 | a(CHEBI:masitinib) decreases act(p(MESH:"Protein-Tyrosine Kinases")) |
| pubmed:30837838 | a(CHEBI:masitinib) regulates path(MESH:"Cell Degranulation") |
| pubmed:30837838 | a(CHEBI:masitinib) regulates path(MESH:"Cell Differentiation") |
| pubmed:30837838 | a(CHEBI:masitinib) regulates path(MESH:"Cell Survival") |
| pubmed:30837838 | a(CHEBI:masitinib) decreases path(MESH:"Neurogenic Inflammation") |
| pubmed:30837838 | a(CHEBI:masitinib) decreases a(MESH:Cytokines) |
| pubmed:30837838 | a(PUBCHEM:68476) negativeCorrelation act(p(HGNC:TARDBP), ma(GO:"nucleic acid binding")) |
| pubmed:30837838 | a(PUBCHEM:68476) increases p(MESH:Caspases) |
| pubmed:30837838 | a(PUBCHEM:9577280) decreases a(CHEBI:"copper(2+)") |
| pubmed:30837838 | a(PUBCHEM:9577280) decreases complex(a(GO:"cytoplasmic stress granule"), p(HGNC:TARDBP)) |
| pubmed:30837838 | a(PUBCHEM:9577280) decreases p(HGNC:TARDBP, frag("274_414"), pmod(MESH:"Protein Aggregates")) |
| pubmed:30837838 | a(PUBCHEM:137275684) decreases a(CHEBI:"copper(2+)") |
| pubmed:30837838 | a(PUBCHEM:137275684) decreases complex(a(GO:"cytoplasmic stress granule"), p(HGNC:TARDBP)) |
| pubmed:30837838 | a(PUBCHEM:137275684) decreases p(HGNC:TARDBP, frag("274_414"), pmod(MESH:"Protein Aggregates")) |
| pubmed:30837838 | complex(a(MESH:"Nuclear Localization Signals"), p(HGNC:KPNB1)) increases deg(p(CONSO:"TDP-43 aggregates")) |
| pubmed:30837838 | complex(p(CONSO:"TDP-43 aggregates"), p(HGNCGENEFAMILY:"Heat shock 70kDa proteins")) increases deg(p(CONSO:"TDP-43 aggregates")) |
| pubmed:30837838 | complex(p(CONSO:"TDP-43 aggregates"), p(HGNCGENEFAMILY:"Heat shock 70kDa proteins")) increases p(HGNC:TARDBP, pmod(MESH:"Protein Refolding")) |
| pubmed:26702100 | p(HGNC:RPS6KB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 389)) negativeCorrelation act(p(HGNCGENEFAMILY:"MTOR complex 1")) |
| pubmed:26702100 | p(HGNC:RPTOR) regulates act(p(HGNC:MTOR)) |
| pubmed:26702100 | p(HGNC:RPTOR) increases p(HGNC:MTOR, loc(GO:lysosome)) |
| pubmed:26702100 | p(HGNC:RPTOR) increases p(HGNC:MTOR) |
| pubmed:26702100 | p(HGNC:RPTOR) regulates p(HGNC:MTOR) |
| pubmed:26702100 | p(HGNC:RPTOR) association p(HGNC:TARDBP) |
| pubmed:26702100 | p(HGNC:RPTOR) increases tloc(p(HGNC:TFEB), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) |
| pubmed:26702100 | p(HGNC:RRAGA) regulates act(p(HGNC:MTOR)) |
| pubmed:26702100 | p(HGNC:RRAGA) increases p(HGNC:MTOR, loc(GO:lysosome)) |
| pubmed:26702100 | p(HGNC:RRAGA) increases p(HGNC:TFEB, loc(GO:lysosome)) |
| pubmed:26702100 | p(HGNC:RRAGA) association p(HGNC:TFEB, loc(GO:lysosome)) |
| pubmed:26702100 | p(HGNC:LAMTOR1) increases p(HGNC:RRAGA, loc(GO:lysosome)) |
| pubmed:26702100 | p(HGNC:LAMTOR1) increases p(HGNC:RRAGC, loc(GO:lysosome)) |
| pubmed:26702100 | complex(a(GO:"Ragulator complex"), p(HGNC:RRAGA), p(HGNCGENEFAMILY:"MTOR complex 1")) increases complex(a(GO:lysosome), p(HGNC:RRAGA)) |
| pubmed:26702100 | complex(a(GO:lysosome), p(HGNC:RRAGA)) increases a(CHEBI:"amino acid") |
| pubmed:26702100 | p(HGNC:RRAGB) decreases p(HGNC:TFEB, loc(GO:nucleus)) |
| pubmed:26702100 | p(HGNC:RRAGB) causesNoChange p(HGNC:TFEB, loc(GO:lysosome)) |
| pubmed:26702100 | p(HGNC:RHEB) increases act(p(HGNC:MTOR)) |
| pubmed:26702100 | p(HGNC:CD63) association a(GO:lysosome) |
| pubmed:26702100 | p(HGNC:TFEB, var("p.Met1_Val30del")) decreases complex(a(GO:lysosome), p(HGNC:RRAGA), p(HGNC:TFEB)) |
| pubmed:26702100 | p(HGNC:TFEB, var("p.Met1_Val30del")) decreases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 211)) |
| pubmed:26702100 | p(HGNC:TFEB, var("p.Met1_Val30del")) increases p(HGNC:TFEB, loc(GO:nucleus)) |
| pubmed:26702100 | complex(a(GO:lysosome), p(HGNC:RRAGA), p(HGNC:TFEB)) increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 211)) |
| pubmed:26702100 | p(HGNC:TFEB, var("p.Gln10Ala"), var("p.Lys11Ala")) decreases complex(a(GO:lysosome), p(HGNC:RRAGA), p(HGNC:TFEB)) |
| pubmed:26702100 | p(HGNC:TFEB, var("p.Gln10Ala"), var("p.Lys11Ala")) decreases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 211)) |
| pubmed:26702100 | p(HGNC:TFEB, var("p.Gln10Ala"), var("p.Lys11Ala")) increases p(HGNC:TFEB, loc(GO:nucleus)) |
| pubmed:26702100 | p(HGNC:ATG9B) association bp(GO:autophagy) |
| pubmed:28019679 | bp(GO:"innate immune response") increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:28019679 | a(MESH:"Toll-Like Receptors") increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:28019679 | composite(a(CHEBI:amyloid-beta), p(HGNC:CTSB)) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:28019679 | composite(a(CHEBI:amyloid-beta), p(HGNC:CD36)) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:28019679 | complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP1)) |
| pubmed:23702978 | complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP1)) |
| pubmed:28019679 | act(complex(GO:"NLRP1 inflammasome complex")) increases act(p(HGNC:CASP6)) |
| pubmed:28019679 | act(complex(GO:"NLRP1 inflammasome complex")) increases a(CHEBI:"amyloid-beta polypeptide 42") |
| pubmed:28019679 | complex(GO:"NLRP1 inflammasome complex") increases bp(GO:pyroptosis) |
| pubmed:28019679 | complex(GO:"NLRP1 inflammasome complex") increases path(CONSO:CONSO00027) |
| pubmed:23702978 | complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP5)) |
| pubmed:24561250 | complex(GO:"NLRP1 inflammasome complex") increases p(HGNC:IL1B) |
| pubmed:24561250 | act(complex(GO:"NLRP1 inflammasome complex")) increases p(HGNC:IL1B) |
| pubmed:24561250 | act(complex(GO:"NLRP1 inflammasome complex")) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:24561250 | act(complex(GO:"NLRP1 inflammasome complex")) increases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:23702978 | complex(p(HGNC:CASP1), p(HGNC:CASP1)) increases act(p(HGNC:CASP1)) |
| pubmed:23702978 | bp(GO:"cell activation") increases p(HGNC:IL18) |
| pubmed:23702978 | p(HGNC:NLRP6) increases bp(GO:"negative regulation of innate immune response") |
| pubmed:23702978 | p(HGNC:NLRP12) increases bp(GO:"dendritic cell migration") |
| pubmed:23702978 | p(HGNC:NLRP12) increases bp(GO:"negative regulation of NIK/NF-kappaB signaling") |
| pubmed:23702978 | complex(GO:"IPAF inflammasome complex") increases act(p(HGNC:CASP1)) |
| pubmed:24561250 | complex(GO:"IPAF inflammasome complex") increases p(HGNC:IL1B) |
| pubmed:24561250 | complex(GO:"IPAF inflammasome complex") increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:24561250 | act(complex(GO:"IPAF inflammasome complex")) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:24561250 | complex(GO:"IPAF inflammasome complex") increases p(HGNC:IL1B) |
| pubmed:24561250 | complex(GO:"IPAF inflammasome complex") association path(MESH:"Alzheimer Disease") |
| pubmed:23702978 | composite(complex(GO:"NLRP1 inflammasome complex"), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1)) |
| pubmed:23702978 | composite(complex(GO:"IPAF inflammasome complex"), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1)) |
| pubmed:23702978 | act(p(HGNC:IFI16)) increases act(p(HGNC:TMEM173)) |
| pubmed:23702978 | act(p(HGNC:DDX58)) increases act(p(HGNC:MAVS)) |
| pubmed:23702978 | a(CHEBI:"RNA fragment") increases act(p(HGNC:DDX58)) |
| pubmed:27314526 | a(CHEBI:"RNA fragment") increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:23702978 | act(p(HGNC:MAVS)) increases bp(GO:"response to type I interferon") |
| pubmed:23702978 | a(CHEBI:"DNA polyanion") increases act(p(HGNC:IFI16)) |
| pubmed:23702978 | act(p(HGNC:TMEM173)) increases bp(GO:"response to type I interferon") |
| pubmed:23702978 | a(CHEBI:"muramyl dipeptide") increases act(p(HGNC:NLRP1)) |
| pubmed:23702978 | complex(a(CHEBI:"muramyl dipeptide"), p(HGNC:NLRP1)) increases act(complex(GO:"inflammasome complex")) |
| pubmed:23702978 | complex(p(HGNC:NLRP1), p(HGNC:NOD2)) increases act(complex(GO:"inflammasome complex")) |
| pubmed:23702978 | act(p(HGNC:NAIP)) increases complex(GO:"IPAF inflammasome complex") |
| pubmed:24561250 | p(HGNC:NAIP) increases act(complex(GO:"IPAF inflammasome complex")) |
| pubmed:23702978 | p(HGNC:SCAF11) increases bp(GO:pyroptosis) |
| pubmed:23702978 | act(p(HGNC:SCAF11)) increases bp(GO:pyroptosis) |
| pubmed:23702978 | a(CHEBI:"LPS with O-antigen") increases bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") |
| pubmed:23702978 | bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") regulates tloc(a(MESH:"Interferon Type I"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:23702978 | bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases p(HGNC:SCAF11) |
| pubmed:23702978 | bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases act(p(HGNC:IFNAR1)) |
| pubmed:23702978 | bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases act(p(HGNC:CASP8)) |
| pubmed:23702978 | a(MESH:"Interferon Type I") decreases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:23702978 | a(MESH:"Interferon Type I") decreases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:23702978 | p(HGNC:PRTN3) increases act(p(HGNC:IL1B)) |
| pubmed:23702978 | act(p(HGNC:CLEC7A)) increases act(p(HGNC:SYK)) |
| pubmed:23702978 | complex(p(HGNC:CASP8), p(HGNC:MALT1)) increases complex(p(HGNC:CASP8), p(HGNC:MALT1), p(HGNC:PYCARD)) |
| pubmed:23702978 | complex(p(HGNC:CASP8), p(HGNC:MALT1), p(HGNC:PYCARD)) increases act(p(HGNC:IL1B)) |
| pubmed:23702978 | complex(GO:ripoptosome) increases act(p(HGNC:CASP8)) |
| pubmed:23702978 | complex(GO:ripoptosome) increases act(p(HGNC:RIPK3)) |
| pubmed:23702978 | p(HGNC:XIAP) decreases complex(GO:ripoptosome) |
| pubmed:23702978 | p(HGNC:BIRC3) decreases complex(GO:ripoptosome) |
| pubmed:23702978 | act(p(HGNC:RIPK3)) increases act(p(HGNC:IL1B)) |
| pubmed:23702978 | act(p(HGNC:RIPK3)) increases act(p(HGNC:CASP1)) |
| pubmed:23702978 | act(p(HGNC:RIPK3)) increases act(p(HGNC:CASP8)) |
| pubmed:23702978 | p(FPLX:TNFRSF) increases p(HGNC:NLRP3) |
| pubmed:23702978 | p(HGNC:BRCC3) decreases p(HGNC:NLRP3, pmod(go:0016567 ! "protein ubiquitination")) |
| pubmed:23702978 | p(FPLX:IFNB) increases p(HGNC:AIM2) |
| pubmed:23702978 | act(p(HGNC:PRKCD), ma(go:0016301 ! "kinase activity")) increases p(HGNC:NLRC4, pmod(go:0006468 ! "protein phosphorylation", Ser)) |
| pubmed:23702978 | g(HGNC:NLRP3, var("?")) positiveCorrelation path(MESH:"Cryopyrin-Associated Periodic Syndromes") |
| pubmed:23702978 | path(MESH:"Cryopyrin-Associated Periodic Syndromes") positiveCorrelation g(HGNC:NLRP3, var("?")) |
| pubmed:23702978 | bp(GO:"CD4-positive, alpha-beta T cell activation") decreases act(complex(GO:"NLRP1 inflammasome complex")) |
| pubmed:23702978 | bp(GO:"CD4-positive, alpha-beta T cell activation") decreases act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:23702978 | p(HGNC:NLRP3, pmod(go:0017014 ! "protein nitrosylation")) decreases act(p(HGNC:NLRP3)) |
| pubmed:23702978 | a(MESH:Interferons) increases p(HGNC:AIM2) |
| pubmed:23702978 | a(MESH:Interferons) decreases p(HGNC:IL1B) |
| pubmed:23702978 | a(MESH:Interferons) decreases act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:23702978 | m(HGNC:MIR223) decreases p(HGNC:NLRP3) |
| pubmed:23702978 | act(complex(GO:apoptosome)) increases act(p(HGNC:CASP9)) |
| pubmed:23702978 | p(HGNC:MAP3K7) association a(CHEBI:"calcium(2+)") |
| pubmed:23702978 | p(HGNC:CASP9, pmod(go:0017014 ! "protein nitrosylation")) decreases act(p(HGNC:CASP9)) |
| pubmed:23702978 | p(HGNC:CASP1, pmod(go:0017014 ! "protein nitrosylation")) decreases act(p(HGNC:CASP1)) |
| pubmed:23702978 | complex(p(HGNC:CARD8), p(HGNC:CASP9)) decreases act(p(HGNC:CASP9)) |
| pubmed:23702978 | complex(p(HGNC:CASP1), p(MGI:Casp12)) decreases act(p(HGNC:CASP1)) |
| pubmed:23702978 | p(HGNC:CARD18) decreases act(p(HGNC:CASP1)) |
| pubmed:23702978 | p(HGNC:CARD16) decreases act(p(HGNC:CASP1)) |
| pubmed:23702978 | p(HGNC:CARD17) decreases p(HGNC:IL1B) |
| pubmed:23702978 | p(HGNC:PYDC1) decreases complex(complex(GO:"inflammasome complex"), p(HGNC:PYCARD)) |
| pubmed:23702978 | p(HGNC:PYDC2) decreases complex(complex(GO:"inflammasome complex"), p(HGNC:PYCARD)) |
| pubmed:23702978 | p(MGI:Mefv) decreases tloc(p(MGI:Il1b), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) |
| pubmed:23702978 | composite(p(FPLX:HSP90), p(HGNC:SUGT1)) increases act(p(HGNC:NLRP3)) |
| pubmed:24561250 | composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:PYCARD) |
| pubmed:24561250 | composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:PYCARD) |
| pubmed:24561250 | composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) increases p(HGNC:IL1B) |
| pubmed:24561250 | composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) increases p(HGNC:IL1B) |
| pubmed:24561250 | composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:CASP1) |
| pubmed:24561250 | composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:NLRP2) |
| pubmed:24561250 | composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) increases p(HGNC:IL18) |
| pubmed:24561250 | p(HGNC:NLRP2) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pubmed:24561250 | p(INTERPRO:"Leucine-rich repeat-containing adjacent domain") partOf a(MESH:"NLR Proteins") |
| pubmed:24561250 | p(INTERPRO:"NACHT-associated domain") partOf a(MESH:"NLR Proteins") |
| pubmed:24561250 | p(INTERPRO:"DAPIN domain") partOf p(INTERPRO:"NACHT-associated domain") |
| pubmed:24561250 | p(INTERPRO:"CARD domain") partOf p(INTERPRO:"NACHT-associated domain") |
| pubmed:24561250 | p(INTERPRO:"BIR repeat") partOf p(INTERPRO:"NACHT-associated domain") |
| pubmed:24561250 | a(MESH:"Pathogen-Associated Molecular Pattern Molecules") increases complex(GO:"inflammasome complex") |
| pubmed:24561250 | a(MESH:"Pathogen-Associated Molecular Pattern Molecules") increases act(complex(GO:"inflammasome complex")) |
| pubmed:30988501 | a(MESH:"Pathogen-Associated Molecular Pattern Molecules") decreases path(MESH:"Illness Behavior") |
| pubmed:24561250 | complex(a(MESH:"NLR Proteins"), p(INTERPRO:"NACHT-associated domain")) increases complex(GO:"inflammasome complex") |
| pubmed:24561250 | complex(p(HGNC:CASP1), p(HGNC:NLRP1), p(HGNC:PYCARD)) increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pubmed:24561250 | complex(p(HGNC:CASP1), p(HGNC:NLRP3), p(HGNC:PYCARD)) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pubmed:24561250 | a(MESH:Bacteria) increases act(complex(GO:"inflammasome complex")) |
| pubmed:24561250 | a(MESH:Fungi) increases act(complex(GO:"inflammasome complex")) |
| pubmed:24561250 | a(CHEBI:"potassium aluminium sulfate") increases act(complex(GO:"inflammasome complex")) |
| pubmed:24561250 | p(MGI:P2rx4) increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pubmed:24561250 | p(MGI:P2rx4) increases p(HGNC:IL1B) |
| pubmed:24561250 | p(MGI:P2rx4) increases p(HGNC:IL1B) |
| pubmed:24561250 | p(MGI:P2rx4) increases act(complex(GO:"inflammasome complex")) |
| pubmed:24561250 | p(MGI:P2rx7) increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pubmed:24561250 | composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2), p(HGNC:P2RX7), p(HGNC:PANX1)) increases p(HGNC:IL1B) |
| pubmed:24561250 | p(HGNC:PANX1) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pubmed:24561250 | p(HGNC:PANX1) increases p(HGNC:IL1B) |
| pubmed:24561250 | p(HGNC:PANX1) increases p(HGNC:IL18) |
| pubmed:24561250 | a(CHEBI:hexadecanoate) increases complex(GO:"IPAF inflammasome complex") |
| pubmed:24561250 | a(CHEBI:hexadecanoate) increases act(complex(GO:"IPAF inflammasome complex")) |
| pubmed:24561250 | p(MGI:Nlrp3) increases p(MGI:Il1b) |
| pubmed:24561250 | p(MGI:Nlrp3) increases bp(GO:"amyloid-beta formation") |
| pubmed:24561250 | p(MGI:Nlrp3) increases a(MESH:Neuropathology) |
| pubmed:24561250 | p(MGI:Nlrp3) decreases bp(GO:cognition) |
| pubmed:24561250 | composite(a(CHEBI:hexadecanoate), p(HGNC:PYCARD)) increases p(HGNC:IL1B) |
| pubmed:24561250 | composite(a(CHEBI:hexadecanoate), p(HGNC:NLRC4)) increases p(HGNC:IL1B) |
| pubmed:24561250 | a(CHEBI:"saturated fatty acid") increases p(HGNC:IL1B) |
| pubmed:24561250 | a(CHEBI:probenecid) decreases p(HGNC:PANX1) |
| pubmed:24561250 | a(CHEBI:probenecid) decreases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pubmed:24561250 | a(CHEBI:probenecid) decreases p(HGNC:IL1B) |
| pubmed:24561250 | a(CHEBI:probenecid) decreases p(HGNC:IL18) |
| pubmed:24561250 | a(CHEBI:probenecid) decreases act(complex(GO:"NLRP1 inflammasome complex")) |
| pubmed:24561250 | a(CHEBI:probenecid) increases bp(GO:learning) |
| pubmed:24561250 | a(PUBCHEM:6324599) decreases act(p(HGNC:P2RX7)) |
| pubmed:24561250 | a(PUBCHEM:6324599) decreases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pubmed:24561250 | p(MGI:Casp1) increases bp(GO:"amyloid-beta formation") |
| pubmed:24561250 | p(MGI:Casp1) increases a(MESH:Neuropathology) |
| pubmed:24561250 | p(MGI:Casp1) decreases bp(GO:cognition) |
| pubmed:27314526 | act(p(HGNC:PRSS3)) increases p(HGNC:IL18) |
| pubmed:27314526 | act(p(FPLX:ELA)) increases p(HGNC:IL18) |
| pubmed:27314526 | act(p(HGNC:CTSG)) increases p(HGNC:IL18) |
| pubmed:27314526 | composite(complex(GO:"NLRP3 inflammasome complex"), p(HGNC:CASP1), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1)) |
| pubmed:27314526 | path(MESH:Periodontitis) decreases bp(GO:cognition) |
| pubmed:30988501 | bp(GO:"neuron-glial cell signaling") increases bp(GO:cognition) |
| pubmed:30988501 | bp(GO:"neuron-glial cell signaling") increases bp(GO:"social behavior") |
| pubmed:30988501 | bp(GO:"neuron-glial cell signaling") increases bp(GO:learning) |
| pubmed:30988501 | bp(GO:"immune system process") increases bp(GO:cognition) |
| pubmed:30988501 | bp(GO:"immune system process") increases bp(GO:"social behavior") |
| pubmed:30988501 | bp(GO:"immune system process") increases bp(GO:learning) |
| pubmed:30988501 | p(HGNC:C1QBP) increases bp(GO:"complement-mediated synapse pruning") |
| pubmed:30988501 | p(HGNC:C1QBP) increases deg(a(MESH:Neurons)) |
| pubmed:30988501 | p(INTERPRO:"Chemokine receptor family") increases bp(GO:"central nervous system development") |
| pubmed:30988501 | p(HGNC:ACKR3) increases bp(GO:"cell migration") |
| pubmed:30988501 | a(MESH:"Extracellular Vesicles") increases bp(GO:"regulation of action potential firing rate") |
| pubmed:30988501 | p(MESH:"Receptors, Antigen, T-Cell") increases bp(GO:neurogenesis) |
| pubmed:30988501 | bp(MESH:Sleep) decreases a(MESH:"Waste Products") |
| pubmed:30988501 | bp(MESH:Sleep) decreases path(CONSO:neurotoxicity) |
| pubmed:30988501 | path(MESH:"Systemic Inflammatory Response Syndrome") increases path(MESH:"Illness Behavior") |
| pubmed:30988501 | path(MESH:"Illness Behavior") increases path(MESH:"Mood Disorders") |
| pubmed:30988501 | path(MESH:"Illness Behavior") increases path(MESH:"Social Behavior Disorders") |
| pubmed:30988501 | path(MESH:"Illness Behavior") association bp(GO:cognition) |
| pubmed:30988501 | path(MESH:"Illness Behavior") association bp(MESH:"Immunity, Cellular") |
| pubmed:30988501 | path(MESH:"Social Behavior") association bp(MESH:"Immunity, Cellular") |
| pubmed:30988501 | path(MESH:"Social Behavior Disorders") increases bp(MESH:Survival) |
| pubmed:30988501 | p(MESH:"Receptors, Cytokine") increases act(a(MESH:Brain)) |
| pubmed:30988501 | bp(GO:"monoamine transport") decreases path(CONSO:neurotoxicity) |
| pubmed:30988501 | a(MESH:"Streptococcus pyogenes") increases path(MESH:Infection) |
| pubmed:30988501 | a(MESH:"Streptococcus pyogenes") increases path(MESH:"Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections") |
| pubmed:30988501 | a(MESH:"Streptococcus pyogenes") increases path(MESH:"Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections") |
| pubmed:30988501 | a(MESH:"Streptococcus pyogenes") increases path(MESH:Chorea) |
| pubmed:30988501 | path(MESH:"Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections") increases bp(MESH:"Molecular Mimicry") |
| pubmed:30988501 | path(DOID:"rheumatic fever") association path(MESH:Chorea) |
| pubmed:30988501 | path(MESH:"Streptococcal Infections") increases path(MESH:"Obsessive-Compulsive Disorder") |
| pubmed:30988501 | path(MESH:"Streptococcal Infections") increases path(DOID:"tic disorder") |
| pubmed:30988501 | path(MESH:"Streptococcal Infections") increases path(MESH:"Motor Disorders") |
| pubmed:30988501 | path(MESH:"Cytomegalovirus Infections") increases path(HP:"Abnormal proportion of CD4+ effector memory cells") |
| pubmed:30988501 | path(MESH:"Cytomegalovirus Infections") increases path(HP:"Reduced proportion of naive T cells") |
| pubmed:30988501 | path(MESH:"Cytomegalovirus Infections") decreases bp(GO:cognition) |
| pubmed:30988501 | path(MESH:"Cytomegalovirus Infections") decreases bp(GO:cognition) |
| pubmed:30988501 | path(HP:"Helicobacter pylori infection") decreases bp(GO:cognition) |
| pubmed:30988501 | a(MESH:"Herpesvirus 1, Human") decreases bp(GO:cognition) |
| pubmed:30988501 | a(MESH:"Herpesvirus 1, Human") decreases bp(GO:cognition) |
| pubmed:30988501 | a(MESH:"Herpesvirus 1, Human") positiveCorrelation path(DOID:"Alzheimer's disease") |
| pubmed:30988501 | a(MESH:"Herpesvirus 1, Human") increases a(CHEBI:amyloid-beta, loc(GO:intracellular)) |
| pubmed:30988501 | a(MESH:"Herpesvirus 1, Human") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:30988501 | a(MESH:"Herpesvirus 1, Human") association path(MESH:"Plaque, Amyloid") |
| pubmed:30988501 | a(MESH:"Herpesvirus 1, Human") decreases bp(GO:autophagy) |
| pubmed:30988501 | a(MESH:"Herpesvirus 1, Human") decreases bp(MESH:"Antigen Presentation") |
| pubmed:30988501 | a(MESH:"Herpesvirus 1, Human") increases p(HGNC:TLR4) |
| pubmed:30988501 | a(MESH:"Herpesvirus 1, Human") increases p(HGNC:IFNA1) |
| pubmed:30988501 | a(MESH:"Herpesvirus 1, Human") increases p(HGNC:IFNB1) |
| pubmed:30988501 | a(MESH:"Herpesvirus 2, Human") decreases bp(GO:cognition) |
| pubmed:30988501 | a(MESH:"Herpesvirus 2, Human") decreases bp(GO:cognition) |
| pubmed:30988501 | path(MESH:Toxoplasmosis) decreases bp(GO:cognition) |
| pubmed:30988501 | path(MESH:"HIV Infections") increases path(MESH:"Neurocognitive Disorders") |
| pubmed:30988501 | path(MESH:"Antiretroviral Therapy, Highly Active") causesNoChange path(MESH:"Neurocognitive Disorders") |
| pubmed:30988501 | bp(GO:pathogenesis) increases bp(GO:"regulation of gene expression, epigenetic") |
| pubmed:30988501 | bp(GO:pathogenesis) positiveCorrelation path(DOID:"neurodegenerative disease") |
| pubmed:30988501 | bp(GO:pathogenesis) increases path(DOID:"neurodegenerative disease") |
| pubmed:30988501 | bp(GO:pathogenesis) decreases bp(GO:cognition) |
| pubmed:30988501 | bp(MESH:"Antigen Presentation") increases path(HP:Autoimmunity) |
| pubmed:30988501 | p(HGNC:IFNA1) biomarkerFor path(CONSO:neuroinflammation) |
| pubmed:30988501 | p(HGNC:IFNA1) biomarkerFor path(CONSO:Neurodegeneration) |
| pubmed:30988501 | bp(HP:"Autoimmune antibody positivity") increases path(HP:Autoimmunity) |
| pubmed:30988501 | bp(HP:"Autoimmune antibody positivity") increases path(HP:"CNS demyelination") |
| pubmed:30988501 | complex(GO:"MHC class II protein complex") increases path(HP:Autoimmunity) |
| pubmed:30988501 | path(DOID:encephalomyelitis) isA path(DOID:"autoimmune disease of the nervous system") |
| pubmed:30988501 | path(HP:"Recurrent upper respiratory tract infections") increases path(MESH:Recurrence) |
| pubmed:30988501 | complex(a(MESH:Autoantibodies), a(MESH:Neuropil)) increases path(HP:Psychosis) |
| pubmed:30988501 | complex(a(MESH:Autoantibodies), p(HGNCGENEFAMILY:"Gamma-aminobutyric acid type A receptor subunits")) increases path(DOID:encephalitis) |
| pubmed:30988501 | complex(a(MESH:Autoantibodies), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor AMPA type subunits")) decreases bp(GO:"regulation of synaptic plasticity") |
| pubmed:30988501 | complex(a(MESH:Autoantibodies), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor AMPA type subunits")) decreases bp(GO:"learning or memory") |
| pubmed:30988501 | complex(a(MESH:Autoantibodies), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) increases bp(GO:"microglial cell activation") |
| pubmed:30988501 | complex(a(MESH:Autoantibodies), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) increases p(HGNC:C1QBP) |
| pubmed:30988501 | path(DOID:"post-traumatic stress disorder") negativeCorrelation p(HGNC:IL6) |
| pubmed:30988501 | path(DOID:"post-traumatic stress disorder") negativeCorrelation p(HGNC:IL2) |
| pubmed:30988501 | path(DOID:"post-traumatic stress disorder") negativeCorrelation p(HGNC:IL1B) |
| pubmed:30988501 | path(DOID:"post-traumatic stress disorder") negativeCorrelation p(HGNC:IL17A) |
| pubmed:30988501 | path(DOID:"post-traumatic stress disorder") negativeCorrelation p(HGNC:CRP) |
| pubmed:30988501 | path(MESH:Neuropsychiatry) association bp(MESH:"Immunity, Innate") |
| pubmed:30988501 | path(MESH:"Hereditary Diffuse Leukoencephalopathy with Spheroids") negativeCorrelation bp(GO:"microglial cell activation") |
| pubmed:30988501 | bp(MESH:"Gastrointestinal Microbiome") increases p(HGNC:IL17A) |
| pubmed:30988501 | bp(MESH:"Immunity, Maternally-Acquired") positiveCorrelation path(DOID:"autism spectrum disorder") |
| pubmed:30988501 | bp(MESH:"Immunity, Maternally-Acquired") negativeCorrelation bp(GO:"embryonic brain development") |
| pubmed:30988501 | bp(GO:"embryonic brain development") negativeCorrelation bp(MESH:"Immunity, Maternally-Acquired") |
| pubmed:30988501 | bp(GO:"embryonic brain development") association act(a(MESH:B-Lymphocytes)) |
| pubmed:30988501 | bp(GO:"embryonic brain development") association bp(MESH:"Antibody Formation") |
| pubmed:30988501 | complex(p(HGNC:CNTNAP2), p(MESH:"Immunoglobulin G")) increases path(MESH:"Neurodevelopmental Disorders") |
| pubmed:30988501 | complex(p(HGNC:CNTNAP2), p(MESH:"Immunoglobulin G")) increases path(MESH:"Social Behavior Disorders") |
| pubmed:30988501 | a(MESH:Steroids) decreases path(DOID:"multiple sclerosis") |
| pubmed:30988501 | path(MESH:Plasmapheresis) decreases path(DOID:"multiple sclerosis") |
| pubmed:30988501 | a(CHEBI:cyclophosphamide) decreases path(DOID:"multiple sclerosis") |
| pubmed:30988501 | composite(a(CHEBI:minocycline), a(CHEBI:risperidone)) negativeCorrelation path(DOID:"autism spectrum disorder") |
| pubmed:30988501 | path(MESH:"Psychosocial Deprivation") positiveCorrelation path(MESH:"Mental Disorders") |
| pubmed:30988501 | path(MESH:"Psychosocial Deprivation") positiveCorrelation path(DOID:"multiple sclerosis") |
| pubmed:30988501 | path(MESH:"Psychosocial Deprivation") increases bp(GO:"microglial cell activation") |
| pubmed:30988501 | p(HGNC:CLDN5) decreases p(HGNC:IL6) |
| pubmed:30988501 | a(MESH:"Synaptic Membranes") decreases path(MESH:Inflammation) |
| pubmed:10887109 | path(MESH:"Growth and Development") increases p(HGNC:CD33, loc(MESH:"Myeloid Progenitor Cells")) |
| pubmed:10887109 | path(MESH:"Growth and Development") regulates p(HGNC:CD33) |
| pubmed:10887109 | complex(complex(GO:"receptor complex"), p(HGNC:CD22)) increases p(HGNC:CD22, pmod(go:0006468 ! "protein phosphorylation", Tyr)) |
| pubmed:10887109 | p(HGNC:CD22, pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases p(HGNC:PTPN6) |
| pubmed:10887109 | p(HGNC:CD22, pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases p(HGNC:PTPN11) |
| pubmed:10887109 | p(HGNC:CD22, pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases p(HGNC:INPP5D) |
| pubmed:10887109 | complex(complex(GO:"receptor complex"), p(HGNC:FCGR2B)) increases p(HGNC:FCGR2B, pmod(go:0006468 ! "protein phosphorylation", Tyr)) |
| pubmed:10887109 | p(HGNC:FCGR2B, pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases p(HGNC:PTPN6) |
| pubmed:10887109 | p(HGNC:FCGR2B, pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases p(HGNC:PTPN11) |
| pubmed:10887109 | p(HGNC:FCGR2B, pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases p(HGNC:INPP5D) |
| pubmed:10887109 | complex(complex(GO:"receptor complex"), p(HGNCGENEFAMILY:"Killer cell immunoglobulin like receptors")) increases p(HGNCGENEFAMILY:"Killer cell immunoglobulin like receptors", pmod(go:0006468 ! "protein phosphorylation", Tyr)) |
| pubmed:10887109 | p(HGNCGENEFAMILY:"Killer cell immunoglobulin like receptors", pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases p(HGNC:PTPN6) |
| pubmed:10887109 | p(HGNCGENEFAMILY:"Killer cell immunoglobulin like receptors", pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases p(HGNC:PTPN11) |
| pubmed:10887109 | p(HGNCGENEFAMILY:"Killer cell immunoglobulin like receptors", pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases p(HGNC:INPP5D) |
| pubmed:10887109 | complex(complex(GO:"receptor complex"), p(HGNC:PILRB)) increases p(HGNC:PILRB, pmod(go:0006468 ! "protein phosphorylation", Tyr)) |
| pubmed:10887109 | p(HGNC:PILRB, pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases p(HGNC:PTPN6) |
| pubmed:10887109 | p(HGNC:PILRB, pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases p(HGNC:PTPN11) |
| pubmed:10887109 | p(HGNC:PILRB, pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases p(HGNC:INPP5D) |
| pubmed:10887109 | complex(complex(GO:"receptor complex"), p(HGNC:CD33)) increases p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340), pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)) |
| pubmed:10887109 | p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340), pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)) increases p(HGNC:PTPN6) |
| pubmed:10887109 | p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340), pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)) increases p(HGNC:PTPN11) |
| pubmed:10887109 | p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340), pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)) increases p(HGNC:INPP5D) |
| pubmed:10887109 | p(HGNC:PTPN11) increases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:PTPN11, pmod(go:0006468 ! "protein phosphorylation", Tyr))) |
| pubmed:10887109 | p(HGNC:PTPN11) increases p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)) |
| pubmed:10887109 | p(HGNC:PTPN11) increases p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)) |
| pubmed:10887109 | p(HGNC:PTPN11) increases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:PTPN11)) |
| pubmed:10887109 | p(HGNC:INPP5D) decreases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:INPP5D)) |
| pubmed:10887109 | a(PUBCHEM:24978557) increases p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr)) |
| pubmed:10887109 | act(p(HGNC:ZAP70), ma(go:0016301 ! "kinase activity")) causesNoChange p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:10887109 | act(p(HGNC:LCK, var("p.Lys273Arg")), ma(go:0016301 ! "kinase activity")) causesNoChange p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:10887109 | act(p(HGNC:SYK, var("p.Lys395Arg")), ma(go:0016301 ! "kinase activity")) causesNoChange p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:10887109 | act(p(HGNC:ZAP70, var("p.Lys369Arg")), ma(go:0016301 ! "kinase activity")) causesNoChange p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation")) |
| pubmed:10887109 | p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)) increases complex(p(HGNC:CD33), p(HGNC:PTPN6)) |
| pubmed:10887109 | p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)) increases complex(p(HGNC:CD33), p(HGNC:PTPN11)) |
| pubmed:10887109 | p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)) regulates bp(GO:"macrophage activation") |
| pubmed:10887109 | p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)) increases complex(p(HGNC:CD33), p(HGNC:PTPN6)) |
| pubmed:10887109 | p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)) increases complex(p(HGNC:CD33), p(HGNC:PTPN11)) |
| pubmed:10887109 | p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)) regulates bp(GO:"macrophage activation") |
| pubmed:10887109 | p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)) decreases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)), p(HGNC:PTPN6, var("p.Arg30Lys"))) |
| pubmed:10887109 | p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)) decreases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)), p(HGNC:PTPN6, var("p.Arg139Lys"))) |
| pubmed:10887109 | complex(p(HGNC:CD33), p(HGNC:PTPN6)) increases act(p(HGNC:PTPN6)) |
| pubmed:10887109 | composite(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)), p(HGNC:PTPN6)) increases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)), p(HGNC:PTPN6)) |
| pubmed:10887109 | composite(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)), p(HGNC:PTPN6)) increases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)), p(HGNC:PTPN6)) |
| pubmed:10887109 | composite(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)), p(HGNC:PTPN11)) increases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)), p(HGNC:PTPN11)) |
| pubmed:10887109 | composite(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)), p(HGNC:PTPN11)) increases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)), p(HGNC:PTPN11)) |
| pubmed:10887109 | composite(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)), p(HGNC:PTPN6)) causesNoChange complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)), p(HGNC:PTPN6)) |
| pubmed:10887109 | composite(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)), p(HGNC:PTPN6)) decreases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)), p(HGNC:PTPN6)) |
| pubmed:10887109 | p(HGNCGENEFAMILY:"Killer cell immunoglobulin like receptors", pmod(go:0006468 ! "protein phosphorylation", Tyr), var("p.Val?Ile")) causesNoChange act(p(HGNC:PTPN6), ma(GO:"phosphatase activity")) |
| pubmed:10887109 | p(HGNCGENEFAMILY:"Killer cell immunoglobulin like receptors", pmod(go:0006468 ! "protein phosphorylation", Tyr), var("p.Val?Leu")) causesNoChange act(p(HGNC:PTPN6), ma(GO:"phosphatase activity")) |
| pubmed:10887109 | p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340), var("p.Leu343Val")) decreases act(p(HGNC:PTPN6), ma(GO:"phosphatase activity")) |
| pubmed:10887109 | p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358), var("p.Leu361Val")) decreases complex(p(HGNC:CD33), p(HGNC:PTPN6)) |
| pubmed:10887109 | act(complex(p(HGNC:PTPN6), p(MESH:Phosphopeptides)), ma(GO:"SH2 domain binding")) increases act(p(HGNC:PTPN6), ma(GO:"phosphatase activity")) |
| pubmed:10887109 | act(complex(p(HGNC:PTPN6), p(MESH:Phosphopeptides)), ma(GO:"SH2 domain binding")) increases p(HGNC:PTPN6) |
| pubmed:10887109 | p(HGNC:PTPN6, var("p.Arg30Lys")) decreases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)), p(HGNC:PTPN6)) |
| pubmed:10887109 | p(HGNC:PTPN6, var("p.Arg136Lys")) increases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)), p(HGNC:PTPN6)) |
| pubmed:10887109 | complex(p(HGNC:CD33), p(HGNC:FCGR1A), p(HGNC:IFNG)) decreases a(CHEBI:"calcium(2+)") |
| pubmed:10887109 | act(p(HGNC:FCGR1A)) association p(HGNC:CD33) |
| pubmed:10887109 | p(HGNC:FCGR1A) increases bp(GO:"calcium ion import") |
| pubmed:10887109 | complex(p(HGNC:FCGR1A), p(HGNC:IFNG)) increases a(CHEBI:"calcium(2+)") |
| pubmed:10887109 | p(HGNC:PTPN6, var("p.Cys453Ser")) increases act(p(HGNC:CD33)) |
| pubmed:10887109 | p(HGNC:PTPN6, var("p.Cys453Ser")) increases act(p(HGNC:FCGR1A)) |
| pubmed:10887109 | p(HGNC:PTPN6, var("p.Cys453Ser")) increases bp(GO:"calcium ion import") |
This section lists all of the namespaces that are defined in the original BEL document.
This section lists all of the annotations that are defined in the original BEL document.
The source BEL document contained annotations defined as a list. Click each link to export
the list definition as a BELANNO file that can hosted externally to promote
re-usability and interoperability. After, you can replace the list definition in the source
BEL with a SET ANNOTATION X AS URL "Y" definition.
| Path | Line | BEL | Message |
|---|---|---|---|
| /Users/cthoyt/dev/conib/conib/ms/correale2017.bel | 303 | path(MESH:"Epstein-Barr Virus Infections") -- p(NCBIGENE:3783744, loc(MESH:"Plasma Cells") |
"3783744" is not in the NCBIGENE namespace |
| /Users/cthoyt/dev/conib/conib/receptors/nordberg2001.bel | 158 | bp(GO:aging) negativeCorrelation r(CONSO:"alpha-4-containing nAChR") |
RNA CONSO:"alpha-4-containing nAChR" should be encoded as one of: Complex |
| /Users/cthoyt/dev/conib/conib/receptors/nordberg2001.bel | 159 | bp(GO:aging) negativeCorrelation r(CONSO:"alpha-7-containing nAChR") |
RNA CONSO:"alpha-7-containing nAChR" should be encoded as one of: Complex |
| /Users/cthoyt/dev/conib/conib/receptors/zoli2018.bel | 218 | p(MESH:"Receptors, Nicotinic",loc(MESH:"GABAergic Neurons")) -- a(CONSO:neurotransmitters) |
"neurotransmitters" is not in the CONSO namespace |
| /Users/cthoyt/dev/conib/conib/receptors/zoli2018.bel | 219 | p(MESH:"Receptors, Nicotinic") reg sec(a(CONSO:neurotransmitters)) |
"neurotransmitters" is not in the CONSO namespace |
| /Users/cthoyt/dev/conib/conib/immunotherapy/kontsekova2014.bel | 117 | p(CONSO:DC8E8) -- path(CONSO:"Braak_Stage I") |
Pathology CONSO:"Braak_Stage I" should be encoded as one of: miRNA, Gene, Complex, RNA, Abundance, Protein |
| /Users/cthoyt/dev/conib/conib/er-stress/doyle2011.bel | 551 | SET MeSHDisease = "Hypoxia" |
"MeSHDisease" is not defined |
| /Users/cthoyt/dev/conib/conib/er-stress/doyle2011.bel | 568 | UNSET MeSHDisease |
"MeSHDisease" is not defined |
| /Users/cthoyt/dev/conib/conib/tau/dennissen2016.bel | 157 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) -- a(CONSO:"Tau epitope, 12E8") |
Abundance CONSO:"Tau epitope, 12E8" should be encoded as one of: Protein |
| /Users/cthoyt/dev/conib/conib/tau/dennissen2016.bel | 158 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"),var("p.Ile277Pro"),var("p.Ile308Pro")) -- a(CONSO:"Tau epitope, 12E8") |
Abundance CONSO:"Tau epitope, 12E8" should be encoded as one of: Protein |
| /Users/cthoyt/dev/conib/conib/tau/dennissen2016.bel | 165 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) -- a(CONSO:"Tau epitope, PHF1") |
Abundance CONSO:"Tau epitope, PHF1" should be encoded as one of: Protein |
| /Users/cthoyt/dev/conib/conib/tau/dennissen2016.bel | 166 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"),var("p.Ile277Pro"),var("p.Ile308Pro")) -- a(CONSO:"Tau epitope, PHF1") |
Abundance CONSO:"Tau epitope, PHF1" should be encoded as one of: Protein |
| /Users/cthoyt/dev/conib/conib/tau/dennissen2016.bel | 174 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) neg a(CONSO:"Tau epitope, AT180") |
Abundance CONSO:"Tau epitope, AT180" should be encoded as one of: Protein |
| /Users/cthoyt/dev/conib/conib/tau/dennissen2016.bel | 175 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) pos a(CONSO:"Tau epitope, AT8") |
Abundance CONSO:"Tau epitope, AT8" should be encoded as one of: Protein |
| /Users/cthoyt/dev/conib/conib/tau/dennissen2016.bel | 176 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"),var("p.Ile277Pro"),var("p.Ile308Pro")) neg a(CONSO:"Tau epitope, AT180") |
Abundance CONSO:"Tau epitope, AT180" should be encoded as one of: Protein |
| /Users/cthoyt/dev/conib/conib/tau/dennissen2016.bel | 177 | p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"),var("p.Ile277Pro"),var("p.Ile308Pro")) pos a(CONSO:"Tau epitope, AT8") |
Abundance CONSO:"Tau epitope, AT8" should be encoded as one of: Protein |
| /Users/cthoyt/dev/conib/conib/tau/tarasoffconway2015.bel | 94 | act(a(CONSO:"Glymphatic System")) -| a(CHEBI:"amyloid-beta",loc(GO:"extracellular region")) |
"Glymphatic System" is not in the CONSO namespace |
| /Users/cthoyt/dev/conib/conib/tau/tarasoffconway2015.bel | 103 | act(p(HGNC:AQP4)) -> act(a(CONSO:"Glymphatic System")) |
"Glymphatic System" is not in the CONSO namespace |
| /Users/cthoyt/dev/conib/conib/tau/tarasoffconway2015.bel | 104 | act(a(CONSO:"Glymphatic System")) -| a(CHEBI:"amyloid-beta",loc(GO:"extracellular region")) |
"Glymphatic System" is not in the CONSO namespace |
| /Users/cthoyt/dev/conib/conib/tau/tarasoffconway2015.bel | 230 | a(CONSO:"amyloid-beta polypeptide 38") isA a(CHEBI:"amyloid-beta") |
"amyloid-beta polypeptide 38" is not in the CONSO namespace |
| /Users/cthoyt/dev/conib/conib/tau/tarasoffconway2015.bel | 423 | bp(CONSO:"perivascular drainage pathways") -| a(CHEBI:"amyloid-beta") |
"perivascular drainage pathways" is not in the CONSO namespace |
| /Users/cthoyt/dev/conib/conib/tau/tarasoffconway2015.bel | 424 | path(MESH:"Alzheimer Disease") neg bp(CONSO:"perivascular drainage pathways") |
"perivascular drainage pathways" is not in the CONSO namespace |
| /Users/cthoyt/dev/conib/conib/tau/tarasoffconway2015.bel | 425 | path(MESH:"Cerebral Amyloid Angiopathy") neg bp(CONSO:"perivascular drainage pathways") |
"perivascular drainage pathways" is not in the CONSO namespace |
| /Users/cthoyt/dev/conib/conib/tau/tarasoffconway2015.bel | 431 | g(CONSO:"APOE e4") neg bp(CONSO:"perivascular drainage pathways") |
"perivascular drainage pathways" is not in the CONSO namespace |
| /Users/cthoyt/dev/conib/conib/tau/tarasoffconway2015.bel | 439 | path(CONSO:"high-fat prenatal maternal diet") -| deg(a(CHEBI:"amyloid-beta")) |
"high-fat prenatal maternal diet" is not in the CONSO namespace |
| /Users/cthoyt/dev/conib/conib/tau/tarasoffconway2015.bel | 448 | p(MGI:Aqp4) -> act(a(CONSO:"Glymphatic System")) |
"Glymphatic System" is not in the CONSO namespace |
| /Users/cthoyt/dev/conib/conib/tau/tarasoffconway2015.bel | 449 | act(a(CONSO:"Glymphatic System")) -| a(CHEBI:"amyloid-beta") |
"Glymphatic System" is not in the CONSO namespace |
| /Users/cthoyt/dev/conib/conib/tau/tarasoffconway2015.bel | 462 | path(MESH:Sleep) -> bp(CONSO:"glymphatic bulk flow") |
"glymphatic bulk flow" is not in the CONSO namespace |
| /Users/cthoyt/dev/conib/conib/tau/xin2018.bel | 106 | a(CONSO:"20 S Proteasome") -> bp(GO:"proteasomal ubiquitin-independent protein catabolic process") |
Abundance CONSO:"20 S Proteasome" should be encoded as one of: Protein |
| /Users/cthoyt/dev/conib/conib/tau/xin2018.bel | 134 | act(a(MESH:Microglia)) -> bp(CONSO:Neurodegeneration) |
BiologicalProcess CONSO:Neurodegeneration should be encoded as one of: Pathology |
| /Users/cthoyt/dev/conib/conib/tau/xin2018.bel | 241 | a(CHEBI:"amyloid-beta") -> bp(CONSO:"mitochondrial dysfunction") |
BiologicalProcess CONSO:"mitochondrial dysfunction" should be encoded as one of: Pathology |
| /Users/cthoyt/dev/conib/conib/tau/xin2018.bel | 274 | a(CONSO:"APOE e4") -| deg(a(CHEBI:"amyloid-beta")) |
Abundance CONSO:"APOE e4" should be encoded as one of: Gene |
| /Users/cthoyt/dev/conib/conib/tau/xin2018.bel | 593 | a(CONSO:"APOE e4") -| deg(a(CHEBI:"amyloid-beta")) |
Abundance CONSO:"APOE e4" should be encoded as one of: Gene |
| /Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel | 1876 | p(NCBIGENE:850633) -> deg(p(CONSO:"TDP-43 aggregates")) |
"850633" is not in the NCBIGENE namespace |
| /Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel | 1877 | p(NCBIGENE:850633) -> deg(p(HGNC:"FUS", pmod(MESH:"Protein Aggregates"))) |
"850633" is not in the NCBIGENE namespace |
| /Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel | 1878 | p(NCBIGENE:850633) -> deg(a(CONSO:"alpha-synuclein aggregates")) |
"850633" is not in the NCBIGENE namespace |
| /Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel | 1885 | p(NCBIGENE:850633, var("p.Ala503Val")) -| p(CONSO:"TDP-43 aggregates") |
"850633" is not in the NCBIGENE namespace |
| /Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel | 1886 | p(NCBIGENE:850633, var("p.Ala503Val")) -| p(HGNC:"TARDBP", loc(GO:"nucleus")) |
"850633" is not in the NCBIGENE namespace |
| /Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel | 1887 | p(NCBIGENE:850633, var("p.Ala503Ser")) -| p(CONSO:"TDP-43 aggregates") |
"850633" is not in the NCBIGENE namespace |
| /Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel | 1888 | p(NCBIGENE:850633, var("p.Ala503Ser")) -| p(HGNC:"TARDBP", loc(GO:"nucleus")) |
"850633" is not in the NCBIGENE namespace |
| /Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel | 1889 | p(NCBIGENE:850633, var("p.Ala503Cys")) -| p(CONSO:"TDP-43 aggregates") |
"850633" is not in the NCBIGENE namespace |
| /Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel | 1890 | p(NCBIGENE:850633, var("p.Ala503Cys")) -| p(HGNC:"TARDBP", loc(GO:"nucleus")) |
"850633" is not in the NCBIGENE namespace |
| /Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel | 1891 | p(NCBIGENE:850633, var("p.Val426Leu")) -| p(CONSO:"TDP-43 aggregates") |
"850633" is not in the NCBIGENE namespace |
| /Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel | 1892 | p(NCBIGENE:850633, var("p.Val426Leu")) -| p(HGNC:"TARDBP", loc(GO:"nucleus")) |
"850633" is not in the NCBIGENE namespace |
| /Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel | 1894 | p(NCBIGENE:850633, var("p.Ala503Val")) -| p(HGNC:"TARDBP", var("p.Met337Val")) |
"850633" is not in the NCBIGENE namespace |
| /Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel | 1895 | p(NCBIGENE:850633, var("p.Ala503Ser")) -| p(HGNC:"TARDBP", var("p.Met337Val")) |
"850633" is not in the NCBIGENE namespace |
| /Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel | 1896 | p(NCBIGENE:850633, var("p.Ala503Cys")) -| p(HGNC:"TARDBP", var("p.Met337Val")) |
"850633" is not in the NCBIGENE namespace |
| /Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel | 1897 | p(NCBIGENE:850633, var("p.Val426Leu")) -| p(HGNC:"TARDBP", var("p.Met337Val")) |
"850633" is not in the NCBIGENE namespace |
| /Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel | 1908 | p(NCBIGENE:850633, var("p.Ala503Val")) -> deg(p(CONSO:"TDP-43 aggregates")) |
"850633" is not in the NCBIGENE namespace |
| /Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel | 1909 | p(NCBIGENE:850633, var("p.Ala503Ser")) -> deg(p(CONSO:"TDP-43 aggregates")) |
"850633" is not in the NCBIGENE namespace |
| /Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel | 1910 | p(NCBIGENE:850633, var("p.Ala503Val")) -> deg(p(HGNC:"FUS", pmod(MESH:"Protein Aggregates"))) |
"850633" is not in the NCBIGENE namespace |
| /Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel | 1911 | p(NCBIGENE:850633, var("p.Ala503Ser")) -> deg(p(HGNC:"FUS", pmod(MESH:"Protein Aggregates"))) |
"850633" is not in the NCBIGENE namespace |
| /Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel | 1912 | p(NCBIGENE:850633, var("p.Ala503Val")) -> deg(a(CONSO:"alpha-synuclein aggregates")) |
"850633" is not in the NCBIGENE namespace |
| /Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel | 1913 | p(NCBIGENE:850633, var("p.Ala503Ser")) -> deg(a(CONSO:"alpha-synuclein aggregates")) |
"850633" is not in the NCBIGENE namespace |
| /Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel | 1921 | p(NCBIGENE:855725) -| p(CONSO:"TDP-43 aggregates") |
"855725" is not in the NCBIGENE namespace |